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Charles Weissmann

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Julie A Edgeworth; Nathalie Gros; Jack Alden; Susan Joiner; Jonathan D F Wadsworth; Jackie Linehan; Sebastian Brandner; Graham S Jackson; Charles Weissmann; John Collinge
Spontaneous generation of mammalian prions.
Julie Ann Edgeworth; Graham S Jackson; Anthony R Clarke; Charles Weissmann; John Collinge
Highly sensitive, quantitative cell-based assay for prions adsorbed to solid surfaces.
Christian Julius; Gregor Hutter; Ulrich Wagner; Harald Seeger; Veronika Kana; Jan Kranich; Peter-Christian Klöhn; Peter Klöhn; Charles Weissmann; Gino Miele; Adriano Aguzzi
Transcriptional stability of cultured cells upon prion infection.

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All Publications

2010: Julie A Edgeworth; Nathalie Gros; Jack Alden; Susan Joiner; Jonathan D F Wadsworth; Jackie Linehan; Sebastian Brandner; Graham S Jackson; Charles Weissmann; John Collinge
Spontaneous generation of mammalian prions.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14402-6.
2009: Julie Ann Edgeworth; Graham S Jackson; Anthony R Clarke; Charles Weissmann; John Collinge
Highly sensitive, quantitative cell-based assay for prions adsorbed to solid surfaces.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3479-83.
2008: Christian Julius; Gregor Hutter; Ulrich Wagner; Harald Seeger; Veronika Kana; Jan Kranich; Peter-Christian Klöhn; Peter Klöhn; Charles Weissmann; Gino Miele; Adriano Aguzzi
Transcriptional stability of cultured cells upon prion infection.
Journal of molecular biology 2008;375(5):1222-33.
2005: Graham S Jackson; Edward McKintosh; Eckhard Flechsig; Kanella Prodromidou; Petra Hirsch; Jacqueline M Linehan; Sebastian Brandner; Anthony R Clarke; Charles Weissmann; John Collinge
An enzyme-detergent method for effective prion decontamination of surgical steel.
The Journal of general virology 2005;86(Pt 3):869-78.
2005: Mathias Heikenwalder; Nicolas Zeller; Harald Seeger; Marco Prinz; Peter-Christian Klöhn; Petra Schwarz; Nancy H Ruddle; Charles Weissmann; Adriano Aguzzi
Chronic lymphocytic inflammation specifies the organ tropism of prions.
Science (New York, N.Y.) 2005;307(5712):1107-10.
2005: Charles Weissmann; Adriano Aguzzi
Approaches to therapy of prion diseases.
Annual review of medicine 2005;56():321-44.
2004: Charles Weissmann
The state of the prion.
Nature reviews. Microbiology 2004;2(11):861-71.
2004: Eckhard Flechsig; Charles Weissmann
The role of PrP in health and disease.
Current molecular medicine 2004;4(4):337-53.
2004: Lucy Anderson; Daniela Rossi; Jacqueline M Linehan; Sebastian Brandner; Charles Weissmann
Transgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairment.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3644-9.
2004: Charles Weissmann; Hansruedi Büeler
A mouse to remember.
Cell 2004;116(2 Suppl):S111-3, 2 p following S113.
2003: Peter-Christian Klöhn; L Stoltze; Eckhard Flechsig; Masato Enari; Charles Weissmann
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11666-71.
2003: Eckhard Flechsig; Ivan Hegyi; Rainer Leimeroth; Armando Zuniga; Daniela Rossi; Antonio Cozzio; Petra Schwarz; Thomas Rülicke; Jürgen Götz; Adriano Aguzzi; Charles Weissmann
Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia.
The EMBO journal 2003;22(12):3095-101.
2003: Sarah J Tabrizi; C L Elliott; Charles Weissmann
Ethical issues in human prion diseases.
British medical bulletin 2003;66():305-16.
2003: Charles Weissmann; Eckhard Flechsig
PrP knock-out and PrP transgenic mice in prion research.
British medical bulletin 2003;66():43-60.
2002: Charles Weissmann; Masato Enari; Peter-Christian Klöhn; Daniela Rossi; Eckhard Flechsig
Transmission of prions.
Proceedings of the National Academy of Sciences of the United States of America 2002;99 Suppl 4():16378-83.
2002: Charles Weissmann; Masato Enari; Peter-Christian Klöhn; Daniela Rossi; Eckhard Flechsig
Transmission of prions.
The Journal of infectious diseases 2002;186 Suppl 2():S157-65.
2002: Charles Weissmann
Molecular genetics of transmissible spongiform encephalopathies: an introduction.
The Journal of toxicological sciences 2002;27(2):69-77.
2002: Charles Weissmann; Masato Enari; Peter-Christian Klöhn; Daniela Rossi; Eckhard Flechsig
Molecular biology of prions.
Acta neurobiologiae experimentalis 2002;62(3):153-66.
2001: Eckhard Flechsig; Ivan Hegyi; Masato Enari; Petra Schwarz; John Collinge; Charles Weissmann
Transmission of scrapie by steel-surface-bound prions.
Molecular medicine (Cambridge, Mass.) 2001;7(10):679-84.
2001: Masato Enari; Eckhard Flechsig; Charles Weissmann
Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9295-9.
2001: Fabio Montrasio; Antonio Cozzio; Eckhard Flechsig; Daniela Rossi; Michael A Klein; Thomas Rülicke; Alex J Raeber; C A Vosshenrich; J Proft; Adriano Aguzzi; Charles Weissmann
B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):4034-7.
2001: Charles Weissmann; Alex J Raeber; Fabio Montrasio; Ivan Hegyi; Rico Frigg; Michael A Klein; Adriano Aguzzi
Prions and the lymphoreticular system.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1406):177-84.
2001: Daniela Rossi; Antonio Cozzio; Eckhard Flechsig; Michael A Klein; Thomas Rülicke; Adriano Aguzzi; Charles Weissmann
Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain.
The EMBO journal 2001;20(4):694-702.
2001: Alex J Raeber; Fabio Montrasio; Ivan Hegyi; Rico Frigg; Michael A Klein; Adriano Aguzzi; Charles Weissmann
Studies on prion replication in spleen.
Developmental immunology 2001;8(3-4):291-304.
2000: Sebastian Brandner; Michael A Klein; Rico Frigg; Vladimir Pekarik; P Parizek; Alex J Raeber; Markus Glatzel; Petra Schwarz; Thomas Rülicke; Charles Weissmann; Adriano Aguzzi
Neuroinvasion of prions: insights from mouse models.
Experimental physiology 2000;85(6):705-12.
2000: Eckhard Flechsig; David H Shmerling; Ivan Hegyi; Alex J Raeber; Marc Fischer; Antonio Cozzio; C von Mering; Adriano Aguzzi; Charles Weissmann
Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice.
Neuron 2000;27(2):399-408.
2000: Y Benninger; S Marino; R Hardegger; Charles Weissmann; Adriano Aguzzi; Sebastian Brandner
Differentiation and histological analysis of embryonic stem cell-derived neural transplants in mice.
Brain pathology (Zurich, Switzerland) 2000;10(3):330-41.
2000: Fabio Montrasio; Rico Frigg; Markus Glatzel; Michael A Klein; F Mackay; Adriano Aguzzi; Charles Weissmann
Impaired prion replication in spleens of mice lacking functional follicular dendritic cells.
Science (New York, N.Y.) 2000;288(5469):1257-9.
1999: Charles Weissmann; Adriano Aguzzi
Perspectives: neurobiology. PrP's double causes trouble.
Science (New York, N.Y.) 1999;286(5441):914-5.
1999: Alex J Raeber; Michael A Klein; Rico Frigg; Eckhard Flechsig; Adriano Aguzzi; Charles Weissmann
PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice.
The EMBO journal 1999;18(10):2702-6.
1999: Fulvio Magara; U Müller; Z W Li; Hans-Peter Lipp; Charles Weissmann; M Stagljar; David P Wolfer
Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4656-61.
1999: E Zobeley; Eckhard Flechsig; Antonio Cozzio; Masato Enari; Charles Weissmann
Infectivity of scrapie prions bound to a stainless steel surface.
Molecular medicine (Cambridge, Mass.) 1999;5(4):240-3.
1999: Alex J Raeber; A Sailer; Ivan Hegyi; Michael A Klein; Thomas Rülicke; Marc Fischer; Sebastian Brandner; Adriano Aguzzi; Charles Weissmann
Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3987-92.
1999: Charles Weissmann
Molecular genetics of transmissible spongiform encephalopathies.
The Journal of biological chemistry 1999;274(1):3-6.
1998: Michael A Klein; Rico Frigg; Alex J Raeber; Eckhard Flechsig; Ivan Hegyi; Rolf M Zinkernagel; Charles Weissmann; Adriano Aguzzi
PrP expression in B lymphocytes is not required for prion neuroinvasion.
Nature medicine 1998;4(12):1429-33.
1998: Alex J Raeber; Sebastian Brandner; Michael A Klein; Y Benninger; Christine Huber-Musahl; Rico Frigg; C Roeckl; MB Fischer; Charles Weissmann; Adriano Aguzzi
Transgenic and knockout mice in research on prion diseases.
Brain pathology (Zurich, Switzerland) 1998;8(4):715-33.
1998: Adriano Aguzzi; Charles Weissmann
Prion diseases.
Haemophilia : the official journal of the World Federation of Hemophilia 1998;4(4):619-27.
1998: David H Shmerling; Ivan Hegyi; Marc Fischer; Thomas Blättler; Sebastian Brandner; Jürgen Götz; Thomas Rülicke; Eckhard Flechsig; Antonio Cozzio; C von Mering; C Hangartner; Adriano Aguzzi; Charles Weissmann
Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions.
Cell 1998;93(2):203-14.
1998: Charles Weissmann; Marc Fischer; Alex J Raeber; Hansruedi Büeler; A Sailer; David H Shmerling; Thomas Rülicke; Sebastian Brandner; Adriano Aguzzi
The use of transgenic mice in the investigation of transmissible spongiform encephalopathies.
Revue scientifique et technique (International Office of Epizootics) 1998;17(1):278-90.
1997: Alex J Raeber; Richard E Race; Sebastian Brandner; Suzette A Priola; A Sailer; RA Bessen; Lennart Mucke; J Manson; Adriano Aguzzi; M B Oldstone; Charles Weissmann; Bruce Chesebro
Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie.
The EMBO journal 1997;16(20):6057-65.
1997: Charles Weissmann; Adriano Aguzzi
Bovine spongiform encephalopathy and early onset variant Creutzfeldt-Jakob disease.
Current opinion in neurobiology 1997;7(5):695-700.
1997: Thomas Blättler; Sebastian Brandner; Alex J Raeber; Michael A Klein; T Voigtländer; Charles Weissmann; Adriano Aguzzi
PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain.
Nature 1997;389(6646):69-73.
1997: Adriano Aguzzi; Thomas Blättler; Michael A Klein; A J Räber; Ivan Hegyi; Rico Frigg; Sebastian Brandner; Charles Weissmann
Tracking prions: the neurografting approach.
Cellular and molecular life sciences : CMLS 1997;53(6):485-95.
1997: Adriano Aguzzi; Alex J Raeber; Thomas Blättler; Eckhard Flechsig; M Klein; Charles Weissmann; Sebastian Brandner
Neurotoxicity and neuroinvasiveness of prions.
Journal of neurovirology 1997;3 Suppl 1():S23-4.
1996: Charles Weissmann; Marc Fischer; Alex J Raeber; Hansruedi Büeler; A Sailer; David H Shmerling; Thomas Rülicke; Sebastian Brandner; Adriano Aguzzi
The use of transgenic mice in the investigation of transmissible spongiform encephalopathies.
International journal of experimental pathology 1996;77(6):283-93.
1996: Sebastian Brandner; Alex J Raeber; A Sailer; Thomas Blättler; Marc Fischer; Charles Weissmann; Adriano Aguzzi
Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):13148-51.
1996: Charles Weissmann
The Ninth Datta Lecture. Molecular biology of transmissible spongiform encephalopathies.
FEBS letters 1996;389(1):3-11.
1996: Z W Li; G Stark; Jürgen Götz; Thomas Rülicke; M Gschwind; G Huber; U Müller; Charles Weissmann
Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):6158-62.
1996: Adriano Aguzzi; Charles Weissmann
Sleepless in Bologna: transmission of fatal familial insomnia.
Trends in microbiology 1996;4(4):129-31; discussion 131-2.
1996: Marc Fischer; Thomas Rülicke; Alex J Raeber; A Sailer; M Moser; Bruno Oesch; Sebastian Brandner; Adriano Aguzzi; Charles Weissmann
Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.
The EMBO journal 1996;15(6):1255-64.
1996: Sebastian Brandner; S Isenmann; Alex J Raeber; Marc Fischer; A Sailer; Y Kobayashi; S Marino; Charles Weissmann; Adriano Aguzzi
Normal host prion protein necessary for scrapie-induced neurotoxicity.
Nature 1996;379(6563):339-43.
1996: Charles Weissmann; Marc Fischer; Alex J Raeber; Hansruedi Büeler; A Sailer; David H Shmerling; Thomas Rülicke; Sebastian Brandner; Adriano Aguzzi
The role of PrP in pathogenesis of experimental scrapie.
Cold Spring Harbor symposia on quantitative biology 1996;61():511-22.
1995: Y L Yang; Luiz F L Reis; Jovan Pavlovic; Adriano Aguzzi; R Schäfer; A Kumar; Bryan R G Williams; M Aguet; Charles Weissmann
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.
The EMBO journal 1995;14(24):6095-106.
1995: Charles Weissmann
Molecular biology of transmissible spongiform encephalopathies.
Progress in brain research 1995;105():15-22.
1994: U Müller; N Cristina; Z W Li; David P Wolfer; Hans-Peter Lipp; Thomas Rülicke; Sebastian Brandner; Adriano Aguzzi; Charles Weissmann
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene.
Cell 1994;79(5):755-65.
1994: Hansruedi Büeler; Alex J Raeber; A Sailer; Marc Fischer; Adriano Aguzzi; Charles Weissmann
High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene.
Molecular medicine (Cambridge, Mass.) 1994;1(1):19-30.
1994: Luiz F L Reis; H Ruffner; G Stark; M Aguet; Charles Weissmann
Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes.
The EMBO journal 1994;13(20):4798-806.
1994: A Sailer; Hansruedi Büeler; Marc Fischer; Adriano Aguzzi; Charles Weissmann
No propagation of prions in mice devoid of PrP.
Cell 1994;77(7):967-8.
1994: Charles Weissmann; Hansruedi Büeler; Marc Fischer; A Sailer; Adriano Aguzzi; M Aguet
PrP-deficient mice are resistant to scrapie.
Annals of the New York Academy of Sciences 1994;724():235-40.
1994: Charles Weissmann
The prion connection: now in yeast?
Science (New York, N.Y.) 1994;264(5158):528-30.
1994: Charles Weissmann; Hansruedi Büeler; Marc Fischer; A Sauer; M Aguet
Susceptibility to scrapie in mice is dependent on PrPC.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994;343(1306):431-3.
1993: H Ruffner; Luiz F L Reis; D Näf; Charles Weissmann
Induction of type I interferon genes and interferon-inducible genes in embryonal stem cells devoid of interferon regulatory factor 1.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11503-7.
1993: Charles Weissmann; Hansruedi Büeler; A Sailer; Marc Fischer; M Aguet; Adriano Aguzzi
Role of PrP in prion diseases.
British medical bulletin 1993;49(4):995-1011.
1993: Hansruedi Büeler; Adriano Aguzzi; A Sailer; R A Greiner; P Autenried; M Aguet; Charles Weissmann
Mice devoid of PrP are resistant to scrapie.
Cell 1993;73(7):1339-47.
1993: Charles Weissmann; Hansruedi Büeler; Marc Fischer; M Aguet
Role of the PrP gene in transmissible spongiform encephalopathies.
Intervirology 1993;35(1-4):164-75.
1993: Charles Weissmann; Hansruedi Büeler; Marc Fischer; Horst Bluethmann; M Aguet
Molecular biology of prion diseases.
Developments in biological standardization 1993;80():53-4.
1992: A Sailer; N J MacDonald; Charles Weissmann
Cloning and sequencing of the murine homologue of the human splicing factor U2AF65.
Nucleic acids research 1992;20(9):2374.
1992: Hansruedi Büeler; Marc Fischer; Y Lang; Horst Bluethmann; Hans-Peter Lipp; S J DeArmond; Stanley B Prusiner; M Aguet; Charles Weissmann
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein.
Nature 1992;356(6370):577-82.
1992: A Sailer; K Nagata; D Näf; M Aebi; Charles Weissmann
Interferon regulatory factor-1 (IRF-1) activates the synthetic IRF-1-responsive sequence (GAAAGT)4 in Saccharomyces cerevisiae.
Gene expression 1992;2(4):329-37.
1991: Charles Weissmann
A 'unified theory' of prion propagation.
Nature 1991;352(6337):679-83.
1991: D Näf; S E Hardin; Charles Weissmann
Multimerization of AAGTGA and GAAAGT generates sequences that mediate virus inducibility by mimicking an interferon promoter element.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1369-73.
1990: R Lleonart; D Näf; H Browning; Charles Weissmann
A novel, quantitative bioassay for type I interferon using a recombinant indicator cell line.
Bio/technology (Nature Publishing Company) 1990;8(12):1263-7.
1988: H Hug; M Costas; P Staeheli; M Aebi; Charles Weissmann
Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter.
Molecular and cellular biology 1988;8(8):3065-79.
1988: Bruno Oesch; D F Groth; Stanley B Prusiner; Charles Weissmann
Search for a scrapie-specific nucleic acid: a progress report.
Ciba Foundation symposium 1988;135():209-23.
1986: K Basler; Bruno Oesch; Michael Scott; David Westaway; M Wälchli; D F Groth; M P McKinley; Stanley B Prusiner; Charles Weissmann
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene.
Cell 1986;46(3):417-28.