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Michael Welch

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Suzanne E Lapi; Michael J Welch
A historical perspective on the specific activity of radiopharmaceuticals: what have we learned in the 35years of the ISRC?
Ritu Shrestha; Michael J Welch; Mahmoud Elsabahy; Stephanie Florez-Malaver; Nam S Lee; Yongjian Liu; Hannah Luehmann; Sandani Samarajeewa; Karen L Wooley
Hierarchically assembled theranostic nanostructures for siRNA delivery and imaging applications.
Ang Li; Yongjian Liu; Hannah P Luehmann; Sandani Samarajeewa; Guorong Sun; Michael J Welch; Fuwu Zhang; Shiyi Zhang; Jiong Zou; Karen L Wooley
Synthesis and in vivo pharmacokinetic evaluation of degradable shell cross-linked polymer nanoparticles with poly(carboxybetaine) versus poly(ethylene glycol) surface-grafted coatings.

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2013: Suzanne E Lapi; Michael J Welch
A historical perspective on the specific activity of radiopharmaceuticals: what have we learned in the 35years of the ISRC?
Nuclear medicine and biology 2013;40(3):314-20.
2012: Ritu Shrestha; Michael J Welch; Mahmoud Elsabahy; Stephanie Florez-Malaver; Nam S Lee; Yongjian Liu; Hannah Luehmann; Sandani Samarajeewa; Karen L Wooley
Hierarchically assembled theranostic nanostructures for siRNA delivery and imaging applications.
Journal of the American Chemical Society 2012;134(42):17362-5.
2012: Ang Li; Yongjian Liu; Hannah P Luehmann; Sandani Samarajeewa; Guorong Sun; Michael J Welch; Fuwu Zhang; Shiyi Zhang; Jiong Zou; Karen L Wooley
Synthesis and in vivo pharmacokinetic evaluation of degradable shell cross-linked polymer nanoparticles with poly(carboxybetaine) versus poly(ethylene glycol) surface-grafted coatings.
ACS nano 2012;6(10):8970-82.
2012: Kiran Kumar Solingapuram Sai; Zhude Tu; Michael J Welch; Justin Rothfuss; Kooresh I Shoghi; Wenhua Chu; Brian N Finck; Robert J Gropler; Kun-Eek Kil; Robert H Mach
Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.
Bioorganic & medicinal chemistry letters 2012;22(19):6233-6.
2012: Mai Lin; Tetsuya Mori; David Ranganathan; Raffaella Rossin; Michael J Welch; Aviv Hagooly; Suzanne E Lapi
Long-term evaluation of TiO2-based 68Ge/68Ga generators and optimized automation of [68Ga]DOTATOC radiosynthesis.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2012;70(10):2539-44.
2012: Yoko Hasegawa; Yasuko Murayama; Keiko Nagase; Nobuyuki Oyama; Seiichi Saito; Michael J Welch; Yoichi Arai; Yasuhisa Fujibayashi; Takako Furukawa; Osamu Yokoyama
Monoclonal antibody RM2 as a potential ligand for a new immunotracer for prostate cancer imaging.
Nuclear medicine and biology 2012;39(7):944-7.
2012: Maiko Kume; Paul C Carey; Gregory Gaehle; Evelyn Madrid; William Margenau; Thomas Voller; Michael J Welch; Suzanne E Lapi
A semi-automated system for the routine production of copper-64.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2012;70(8):1803-6.
2012: Amy M Fowler; M Jeyakumar; John A Katzenellenbogen; Robert D Schreiber; Terry L Sharp; Kathryn E Carlson; Szeman Ruby Chan; Carmen S Dence; Nicole M Fettig; Dong Zhou; Michael J Welch
Small-animal PET of steroid hormone receptors predicts tumor response to endocrine therapy using a preclinical model of breast cancer.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2012;53(7):1119-26.
2012: Dexing Zeng; Dong Zhou; Karen L Wooley; Carmen S Dence; John A Katzenellenbogen; Nam S Lee; Yongjian Liu; Michael J Welch
64Cu Core-labeled nanoparticles with high specific activity via metal-free click chemistry.
ACS nano 2012;6(6):5209-19.
2011: Yongjian Liu; Eric D Pressly; Dana R Abendschein; Craig J Hawker; Geoffrey E Woodard; Pamela K Woodard; Michael J Welch
Targeting angiogenesis using a C-type atrial natriuretic factor-conjugated nanoprobe and PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011;52(12):1956-63.
2011: Raffaella Rossin; Tadahiko Kohno; Aviv Hagooly; Terry Sharp; Brian Gliniak; Thomas Arroll; Qing Chen; Art Hewig; Paula Kaplan-Lefko; Greg Friberg; Robert Radinsky; Jeffrey L Evelhoch; Michael J Welch; Dah-Ren Hwang
Characterization of 64Cu-DOTA-conatumumab: a PET tracer for in vivo imaging of death receptor 5.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011;52(6):942-9.
2011: Monica Shokeen; Eric D Pressly; Aviv Hagooly; Alexander Zheleznyak; Nicholas Ramos; Ashley L Fiamengo; Michael J Welch; Craig J Hawker; Carolyn J Anderson
Evaluation of multivalent, functional polymeric nanoparticles for imaging applications.
ACS nano 2011;5(2):738-47.
2011: Yukie Yoshii; Takako Furukawa; Yasushi Kiyono; Ryo Watanabe; Tetsuya Mori; Hiroshi Yoshii; Tatsuya Asai; Hidehiko Okazawa; Michael J Welch; Yasuhisa Fujibayashi
Internal radiotherapy with copper-64-diacetyl-bis (N4-methylthiosemicarbazone) reduces CD133+ highly tumorigenic cells and metastatic ability of mouse colon carcinoma.
Nuclear medicine and biology 2011;38(2):151-7.
2011: Nobuyuki Oyama; Yoko Hasegawa; Yasushi Kiyono; Masato Kobayashi; Yasuhisa Fujibayashi; Datta E Ponde; Carmen Dence; Michael J Welch; Osamu Yokoyama
Early response assessment in prostate carcinoma by ¹⁸F-fluorothymidine following anticancer therapy with docetaxel using preclinical tumour models.
European journal of nuclear medicine and molecular imaging 2011;38(1):81-9.
2010: Eun Chul Cho; Charles Glaus; Jingyi Chen; Michael J Welch; Younan Xia
Inorganic nanoparticle-based contrast agents for molecular imaging.
Trends in molecular medicine 2010;16(12):561-73.
2010: Carmen S Dence; Richard Laforest; Xiankai Sun; Terry L Sharp; Michael J Welch; Robert H Mach
Radiochemical synthesis, rodent biodistribution and tumor uptake, and dosimetry calculations of [¹¹C] methylated LY2181308.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2010;12(6):608-15.
2010: Jae Hak Lee; Hai-Bing Zhou; Carmen S Dence; Kathryn E Carlson; Michael J Welch; John A Katzenellenbogen
Development of [F-18]fluorine-substituted Tanaproget as a progesterone receptor imaging agent for positron emission tomography.
Bioconjugate chemistry 2010;21(6):1096-104.
2010: Yukie Yoshii; Takako Furukawa; Yasushi Kiyono; Ryo Watanabe; Atsuo Waki; Tetsuya Mori; Hiroshi Yoshii; Myungmi Oh; Tatsuya Asai; Hidehiko Okazawa; Michael J Welch; Yasuhisa Fujibayashi
Copper-64-diacetyl-bis (N4-methylthiosemicarbazone) accumulates in rich regions of CD133+ highly tumorigenic cells in mouse colon carcinoma.
Nuclear medicine and biology 2010;37(4):395-404.
2010: Yongjian Liu; Dana Abendschein; Geoffrey E Woodard; Raffaella Rossin; Kyle McCommis; Jie Zheng; Michael J Welch; Pamela K Woodard
Molecular imaging of atherosclerotic plaque with (64)Cu-labeled natriuretic peptide and PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010;51(1):85-91.
2009: Yongjian Liu; Aida Ibricevic; Joel A Cohen; Jessica L Cohen; Sean P Gunsten; Jean M J Fréchet; Michael J Walter; Michael J Welch; Steven L Brody
Impact of hydrogel nanoparticle size and functionalization on in vivo behavior for lung imaging and therapeutics.
Molecular pharmaceutics 2009;6(6):1891-902.
2009: Michael J Welch; Craig J Hawker; Karen L Wooley
The advantages of nanoparticles for PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(11):1743-6.
2009: Yukie Yoshii; Atsuo Waki; Takako Furukawa; Yasushi Kiyono; Tetsuya Mori; Hiroshi Yoshii; Takashi Kudo; Hidehiko Okazawa; Michael J Welch; Yasuhisa Fujibayashi
Tumor uptake of radiolabeled acetate reflects the expression of cytosolic acetyl-CoA synthetase: implications for the mechanism of acetate PET.
Nuclear medicine and biology 2009;36(7):771-7.
2009: Kooresh I Shoghi; Brian N Finck; Kenneth B Schechtman; Terry Sharp; Pilar Herrero; Robert J Gropler; Michael J Welch
In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapy.
Circulation. Cardiovascular imaging 2009;2(5):373-81.
2009: Delphine L Chen; Dong Zhou; Wenhua Chu; Phillip E Herrbrich; Lynne A Jones; Justin Rothfuss; Jacquelyn T Engle; Marco Geraci; Michael J Welch; Robert H Mach
Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomography.
Nuclear medicine and biology 2009;36(6):651-8.
2009: Lihui Wei; Xiuli Zhang; Fabio Gallazzi; Yubin Miao; Xiaofang Jin; Martin W Brechbiel; Heng Xu; Thomas Clifford; Michael J Welch; Jason S Lewis; Thomas P Quinn
Melanoma imaging using (111)In-, (86)Y- and (68)Ga-labeled CHX-A''-Re(Arg11)CCMSH.
Nuclear medicine and biology 2009;36(4):345-54.
2009: Dong Zhou; Hsiaoju Lee; Justin Rothfuss; Delphine L Chen; Datta E Ponde; Michael J Welch; Robert H Mach
Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase.
Journal of medicinal chemistry 2009;52(8):2443-53.
2009: Dong Zhou; Wenhua Chu; Delphine L Chen; Qi Wang; David E Reichert; Justin Rothfuss; Andre D'Avignon; Michael J Welch; Robert H Mach
[18F]- and [11C]-labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [11C]WC-98.
Organic & biomolecular chemistry 2009;7(7):1337-48.
2009: Lihui Wei; Yunpeng Ye; Thaddeus J Wadas; Jason S Lewis; Michael J Welch; Samuel achilefu; Carolyn J Anderson
(64)Cu-labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: comparison of their biological activity.
Nuclear medicine and biology 2009;36(3):277-85.
2009: Dong Zhou; Haibing Zhou; Carl C Jenks; Jason S Lewis; John A Katzenellenbogen; Michael J Welch
Bromination from the macroscopic level to the tracer radiochemical level: (76)Br radiolabeling of aromatic compounds via electrophilic substitution.
Bioconjugate chemistry 2009;20(4):808-16.
2009: Nobuyuki Oyama; Hidehiko Okazawa; Naoya Kusukawa; Taisei Kaneda; Yoshiji Miwa; Hironobu Akino; Yasuhisa Fujibayashi; Yoshiharu Yonekura; Michael J Welch; Osamu Yokoyama
11C-Acetate PET imaging for renal cell carcinoma.
European journal of nuclear medicine and molecular imaging 2009;36(3):422-7.
2009: Tetsuya Mori; Li-Quan Sun; Masato Kobayashi; Yasushi Kiyono; Hidehiko Okazawa; Takako Furukawa; Hidekazu Kawashima; Michael J Welch; Yasuhisa Fujibayashi
Preparation and evaluation of ethyl [(18)F]fluoroacetate as a proradiotracer of [(18)F]fluoroacetate for the measurement of glial metabolism by PET.
Nuclear medicine and biology 2009;36(2):155-62.
2009: Byung Chul Lee; Carmen S Dence; Haibing Zhou; Ephraim E Parent; Michael J Welch; John A Katzenellenbogen
Fluorine-18 labeling and biodistribution studies on peroxisome proliferator-activated receptor-gamma ligands: potential positron emission tomography imaging agents.
Nuclear medicine and biology 2009;36(2):147-53.
2009: Farrokh Dehdashti; Joanne E Mortimer; Kathryn Trinkaus; Michael J Naughton; Matthew Ellis; John A Katzenellenbogen; Michael J Welch; Barry A Siegel
PET-based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancer.
Breast cancer research and treatment 2009;113(3):509-17.
2009: Adah Almutairi; Raffaella Rossin; Monica Shokeen; Aviv Hagooly; Ashwin Ananth; Benjamin Capoccia; Steve Guillaudeu; Dana Abendschein; Carolyn J Anderson; Michael J Welch; Jean M J Fréchet
Biodegradable dendritic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(3):685-90.
2008: Dong Zhou; Terry L Sharp; Nicole M Fettig; Hsiaoju Lee; Jason S Lewis; John A Katzenellenbogen; Michael J Welch
Evaluation of a bromine-76-labeled progestin 16alpha,17alpha-dioxolane for breast tumor imaging and radiotherapy: in vivo biodistribution and metabolic stability studies.
Nuclear medicine and biology 2008;35(6):655-63.
2008: Kooresh I Shoghi; Robert J Gropler; Terry Sharp; Pilar Herrero; Nicole Fettig; Yi Su; Mayurranjan S Mitra; Attila Kovacs; Brian N Finck; Michael J Welch
Time course of alterations in myocardial glucose utilization in the Zucker diabetic fatty rat with correlation to gene expression of glucose transporters: a small-animal PET investigation.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(8):1320-7.
2008: Jason S Lewis; Richard Laforest; Farrokh Dehdashti; Perry W Grigsby; Michael J Welch; Barry A Siegel
An imaging comparison of 64Cu-ATSM and 60Cu-ATSM in cancer of the uterine cervix.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(7):1177-82.
2008: Guorong Sun; Aviv Hagooly; Jinqi Xu; Andreas M Nyström; Zicheng Li; Raffaella Rossin; Dennis A Moore; Karen L Wooley; Michael J Welch
Facile, efficient approach to accomplish tunable chemistries and variable biodistributions for shell cross-linked nanoparticles.
Biomacromolecules 2008;9(7):1997-2006.
2008: Ephraim E Parent; Carmen S Dence; Terry L Sharp; Michael J Welch; John A Katzenellenbogen
7alpha-18F-fluoromethyl-dihydrotestosterone and 7alpha-18F-fluoromethyl-nortestosterone: ligands to determine the role of sex hormone-binding globulin for steroidal radiopharmaceuticals.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(6):987-94.
2008: Ken-ichi Fukukawa; Raffaella Rossin; Aviv Hagooly; Eric D Pressly; Jasmine N Hunt; Benjamin W Messmore; Karen L Wooley; Michael J Welch; Craig J Hawker
Synthesis and characterization of core-shell star copolymers for in vivo PET imaging applications.
Biomacromolecules 2008;9(4):1329-39.
2008: Farrokh Dehdashti; Perry W Grigsby; Jason S Lewis; Richard Laforest; Barry A Siegel; Michael J Welch
Assessing tumor hypoxia in cervical cancer by PET with 60Cu-labeled diacetyl-bis(N4-methylthiosemicarbazone).
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(2):201-5.
2008: Aviv Hagooly; Raffaella Rossin; Michael J Welch
Small molecule receptors as imaging targets.
Handbook of experimental pharmacology 2008;(185 Pt 2):93-129.
2008: Raffaella Rossin; Silvia Muro; Michael J Welch; Vladimir R Muzykantov; Daniel P Schuster
In vivo imaging of 64Cu-labeled polymer nanoparticles targeted to the lung endothelium.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(1):103-11.
2007: Eileen M Burkart; Nandakumar Sambandam; Xianlin Han; Richard W Gross; Michael Courtois; Carolyn M Gierasch; Kooresh Shoghi; Michael J Welch; Daniel P Kelly
Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart.
The Journal of clinical investigation 2007;117(12):3930-9.
2007: Kooresh I Shoghi; Michael J Welch
Hybrid image and blood sampling input function for quantification of small animal dynamic PET data.
Nuclear medicine and biology 2007;34(8):989-94.
2007: Lihui Wei; Yubin Miao; Fabio Gallazzi; Thomas P Quinn; Michael J Welch; Amy L Vāvere; Jason S Lewis
Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma.
Nuclear medicine and biology 2007;34(8):945-53.
2007: Eric D Pressly; Raffaella Rossin; Aviv Hagooly; Ken-Ichi Fukukawa; Benjamin W Messmore; Michael J Welch; Karen L Wooley; Matthew S Lamm; Rohan A Hule; Darrin J Pochan; Craig J Hawker
Structural effects on the biodistribution and positron emission tomography (PET) imaging of well-defined (64)Cu-labeled nanoparticles comprised of amphiphilic block graft copolymers.
Biomacromolecules 2007;8(10):3126-34.
2007: Zhude Tu; Jinbin Xu; Lynne A Jones; Shihong Li; Craig Dumstorff; Suwanna Vangveravong; Delphine L Chen; Kenneth T Wheeler; Michael J Welch; Robert H Mach
Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomography.
Journal of medicinal chemistry 2007;50(14):3194-204.
2007: Raffaella Rossin; Dietmar Berndorff; Matthias Friebe; Ludger M Dinkelborg; Michael J Welch
Small-animal PET of tumor angiogenesis using a (76)Br-labeled human recombinant antibody fragment to the ED-B domain of fibronectin.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2007;48(7):1172-9.
2007: Ephraim E Parent; Carmen S Dence; Carl Jenks; Terry L Sharp; Michael J Welch; John A Katzenellenbogen
Synthesis and biological evaluation of [18F]bicalutamide, 4-[76Br]bromobicalutamide, and 4-[76Br]bromo-thiobicalutamide as non-steroidal androgens for prostate cancer imaging.
Journal of medicinal chemistry 2007;50(5):1028-40.
2007: Datta E Ponde; Carmen S Dence; Nobuyuki Oyama; Joonyoung Kim; Yu-Chong Tai; Richard Laforest; Barry A Siegel; Michael J Welch
18F-fluoroacetate: a potential acetate analog for prostate tumor imaging--in vivo evaluation of 18F-fluoroacetate versus 11C-acetate.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2007;48(3):420-8.
2007: Lihui Wei; Clayton Butcher; Yubin Miao; Fabio Gallazzi; Thomas P Quinn; Michael J Welch; Jason S Lewis
Synthesis and biologic evaluation of 64Cu-labeled rhenium-cyclized alpha-MSH peptide analog using a cross-bridged cyclam chelator.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2007;48(1):64-72.
2006: Heather M Bigott; Richard Laforest; Xiaodong Liu; Ananya Ruangma; Frank Wuest; Michael J Welch
Advances in the production, processing and microPET image quality of technetium-94m.
Nuclear medicine and biology 2006;33(7):923-33.
2006: Hsiaoju Lee; Brian N Finck; Lynne A Jones; Michael J Welch; Robert H Mach
Synthesis and evaluation of a bromine-76-labeled PPARgamma antagonist 2-bromo-5-nitro-N-phenylbenzamide.
Nuclear medicine and biology 2006;33(7):847-54.
2006: Dong Zhou; Wenhua Chu; Justin Rothfuss; Chenbo Zeng; Jinbin Xu; Lynne Jones; Michael J Welch; Robert H Mach
Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis.
Bioorganic & medicinal chemistry letters 2006;16(19):5041-6.
2006: Ephraim E Parent; Carl Jenks; Terry Sharp; Michael J Welch; John A Katzenellenbogen
Synthesis and biological evaluation of a nonsteroidal bromine-76-labeled androgen receptor ligand 3-[76Br]bromo-hydroxyflutamide.
Nuclear medicine and biology 2006;33(6):705-13.
2006: Dong Zhou; Kathryn E Carlson; John A Katzenellenbogen; Michael J Welch
Bromine- and iodine-substituted 16alpha,17alpha-dioxolane progestins for breast tumor imaging and radiotherapy: synthesis and receptor binding affinity.
Journal of medicinal chemistry 2006;49(15):4737-44.
2006: Ephraim E Parent; Carmen S Dence; Terry L Sharp; Michael J Welch; John A Katzenellenbogen
Synthesis and biological evaluation of a fluorine-18-labeled nonsteroidal androgen receptor antagonist, N-(3-[18F]fluoro-4-nitronaphthyl)-cis-5-norbornene-endo-2,3-dicarboxylic imide.
Nuclear medicine and biology 2006;33(5):615-24.
2006: Douglas Rowland; Zhude Tu; Jinbin Xu; Datta E Ponde; Robert H Mach; Michael J Welch
Synthesis and in vivo evaluation of 2 high-affinity 76Br-labeled sigma2-receptor ligands.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(6):1041-8.
2006: Michael J Welch; Jason S Lewis; Joonyoung Kim; Terry L Sharp; Carmen S Dence; Robert J Gropler; Pilar Herrero
Assessment of myocardial metabolism in diabetic rats using small-animal PET: a feasibility study.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(4):689-97.
2006: Robert J Myerson; anurag singh; Heather M Bigott; Bibiana Cha; John Engelbach; Joonyoung Kim; Wayne T Lamoreaux; Eduardo Moros; Petr Novak; Terry L Sharp; William L Straube; Michael J Welch; Mai Xu
Monitoring the effect of mild hyperthermia on tumour hypoxia by Cu-ATSM PET scanning.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2006;22(2):93-115.
2006: Pilar Herrero; Joonyoung Kim; Terry L Sharp; John Engelbach; Jason S Lewis; Robert J Gropler; Michael J Welch
Assessment of myocardial blood flow using 15O-water and 1-11C-acetate in rats with small-animal PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(3):477-85.
2006: Tetsuya Mori; Shingo Kasamatsu; Christoph Mosdzianowski; Michael J Welch; Yoshiharu Yonekura; Yasuhisa Fujibayashi
Automatic synthesis of 16 alpha-[(18)F]fluoro-17beta-estradiol using a cassette-type [(18)F]fluorodeoxyglucose synthesizer.
Nuclear medicine and biology 2006;33(2):281-6.
2006: Ananya Ruangma; Bing Bai; Jason S Lewis; Xiankai Sun; Michael J Welch; Richard Leahy; Richard Laforest
Three-dimensional maximum a posteriori (MAP) imaging with radiopharmaceuticals labeled with three Cu radionuclides.
Nuclear medicine and biology 2006;33(2):217-26.
2006: Joonyoung Kim; Pilar Herrero; Terry Sharp; Richard Laforest; Douglas Rowland; Yu-Chong Tai; Jason S Lewis; Michael J Welch
Minimally invasive method of determining blood input function from PET images in rodents.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(2):330-6.
2006: Li-Quan Sun; Tetsuya Mori; Carmen S Dence; Datta E Ponde; Michael J Welch; Takako Furukawa; Yoshiharu Yonekura; Yasuhisa Fujibayashi
New approach to fully automated synthesis of sodium [18F]fluoroacetate -- a simple and fast method using a commercial synthesizer.
Nuclear medicine and biology 2006;33(1):153-8.
2005: Wenhua Chu; Jun Zhang; Chenbo Zeng; Justin Rothfuss; Zhude Tu; Yunxiang Chu; David E Reichert; Michael J Welch; Robert H Mach
N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.
Journal of medicinal chemistry 2005;48(24):7637-47.
2005: Jeongsoo Yoo; Lucie Tang; Todd A Perkins; Douglas Rowland; Richard Laforest; Jason S Lewis; Michael J Welch
Preparation of high specific activity (86)Y using a small biomedical cyclotron.
Nuclear medicine and biology 2005;32(8):891-7.
2005: Terry L Sharp; Carmen S Dence; John Engelbach; Pilar Herrero; Robert J Gropler; Michael J Welch
Techniques necessary for multiple tracer quantitative small-animal imaging studies.
Nuclear medicine and biology 2005;32(8):875-84.
2005: Jeongsoo Yoo; Carmen S Dence; Terry L Sharp; John A Katzenellenbogen; Michael J Welch
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
Journal of medicinal chemistry 2005;48(20):6366-78.
2005: Richard Laforest; Terry L Sharp; John Engelbach; Nicole M Fettig; Pilar Herrero; Joonyoung Kim; Jason S Lewis; Douglas Rowland; Yu-Chong Tai; Michael J Welch
Measurement of input functions in rodents: challenges and solutions.
Nuclear medicine and biology 2005;32(7):679-85.
2005: Xiankai Sun; Raffaella Rossin; Jeffrey L Turner; Matthew L Becker; Maisie J Joralemon; Michael J Welch; Karen L Wooley
An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution.
Biomacromolecules 2005;6(5):2541-54.
2005: Peter Wolohan; Jeongsoo Yoo; Michael J Welch; David E Reichert
QSAR studies of copper azamacrocycles and thiosemicarbazones: MM3 parameter development and prediction of biological properties.
Journal of medicinal chemistry 2005;48(17):5561-9.
2005: Michael J Welch
Potential and pitfalls of therapy with alpha-particles.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(8):1254-5.
2005: Raffaella Rossin; Dipanjan Pan; Kai Qi; Jeffrey L Turner; Xiankai Sun; Karen L Wooley; Michael J Welch
64Cu-labeled folate-conjugated shell cross-linked nanoparticles for tumor imaging and radiotherapy: synthesis, radiolabeling, and biologic evaluation.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(7):1210-8.
2005: Zhude Tu; Wenhua Chu; Jun Zhang; Carmen S Dence; Michael J Welch; Robert H Mach
Synthesis and in vivo evaluation of [11C]PJ34, a potential radiotracer for imaging the role of PARP-1 in necrosis.
Nuclear medicine and biology 2005;32(5):437-43.
2005: Zhude Tu; Carmen S Dence; Datta E Ponde; Lynne Jones; Kenneth T Wheeler; Michael J Welch; Robert H Mach
Carbon-11 labeled sigma2 receptor ligands for imaging breast cancer.
Nuclear medicine and biology 2005;32(5):423-30.
2005: Paul McQuade; Yubin Miao; Jeongsoo Yoo; Thomas P Quinn; Michael J Welch; Jason S Lewis
Imaging of melanoma using 64Cu- and 86Y-DOTA-ReCCMSH(Arg11), a cyclized peptide analogue of alpha-MSH.
Journal of medicinal chemistry 2005;48(8):2985-92.
2005: Amy L Vavere; Michael J Welch
Preparation, biodistribution, and small animal PET of 45Ti-transferrin.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(4):683-90.
2005: Xiankai Sun; Huafeng Fang; Xiaoxu Li; Raffaella Rossin; Michael J Welch; John-Stephen Taylor
MicroPET imaging of MCF-7 tumors in mice via unr mRNA-targeted peptide nucleic acids.
Bioconjugate chemistry 2005;16(2):294-305.
2005: Heather M Bigott; Ephraim Parent; Leonard Luyt; John A Katzenellenbogen; Michael J Welch
Design and synthesis of functionalized cyclopentadienyl tricarbonylmetal complexes for technetium-94m PET imaging of estrogen receptors.
Bioconjugate chemistry 2005;16(2):255-64.
2005: Hsiu-Chiang Chiu; Attila Kovacs; Robert M Blanton; Xianlin Han; Michael Courtois; Carla Weinheimer; Kathryn A Yamada; Sylvain Brunet; Haodong Xu; Jeanne M Nerbonne; Michael J Welch; Nicole M Fettig; Terry L Sharp; Nandakumar Sambandam; Krista M Olson; Daniel S Ory; Jean E Schaffer
Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy.
Circulation research 2005;96(2):225-33.
2005: Paul McQuade; Katherine E Martin; Thomas C Castle; Michael J Went; Philip J Blower; Michael J Welch; Jason S Lewis
Investigation into 64Cu-labeled Bis(selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agents.
Nuclear medicine and biology 2005;32(2):147-56.
2005: Amy L Vāvere; Richard Laforest; Michael J Welch
Production, processing and small animal PET imaging of titanium-45.
Nuclear medicine and biology 2005;32(2):117-22.
2005: Heather M Bigott; Julie L Prior; David Piwnica-Worms; Michael J Welch
Imaging multidrug resistance P-glycoprotein transport function using microPET with technetium-94m-sestamibi.
Molecular imaging 2005;4(1):30-9.
2005: Jeongsoo Yoo; David E Reichert; Joonyoung Kim; Carolyn J Anderson; Michael J Welch
A potential Dubin-Johnson syndrome imaging agent: synthesis, biodistribution, and microPET imaging.
Molecular imaging 2005;4(1):18-29.
2005: Paul McQuade; Douglas Rowland; Jason S Lewis; Michael J Welch
Positron-emitting isotopes produced on biomedical cyclotrons.
Current medicinal chemistry 2005;12(7):807-18.
2005: Atsushi Obata; Shingo Kasamatsu; Jason S Lewis; Takako Furukawa; Shinji Takamatsu; Jun Toyohara; Tatsuya Asai; Michael J Welch; Susan G Adams; Hideo Saji; Yoshiharu Yonekura; Yasuhisa Fujibayashi
Basic characterization of 64Cu-ATSM as a radiotherapy agent.
Nuclear medicine and biology 2005;32(1):21-8.
2004: Jeongsoo Yoo; David E Reichert; Michael J Welch
Comparative in vivo behavior studies of cyclen-based copper-64 complexes: regioselective synthesis, X-ray structure, radiochemistry, log P, and biodistribution.
Journal of medicinal chemistry 2004;47(26):6625-37.
2004: Pilar Herrero; Carmen S Dence; Terry L Sharp; Michael J Welch; Robert J Gropler
Impact of reversible trapping of tracer and the presence of blood metabolites on measurements of myocardial glucose utilization performed by PET and 18F-fluorodeoxyglucose using the Patlak method.
Nuclear medicine and biology 2004;31(7):883-92.
2004: Paul McQuade; Linda C Knight; Michael J Welch
Evaluation of 64Cu- and 125I-radiolabeled bitistatin as potential agents for targeting alpha v beta 3 integrins in tumor angiogenesis.
Bioconjugate chemistry 2004;15(5):988-96.
2004: Nobuyuki Oyama; Datta E Ponde; Carmen S Dence; Joonyoung Kim; Yu-Chong Tai; Michael J Welch
Monitoring of therapy in androgen-dependent prostate tumor model by measuring tumor proliferation.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004;45(3):519-25.
2004: Carmen S Dence; Pilar Herrero; Sally W Schwarz; Robert H Mach; Robert J Gropler; Michael J Welch
Imaging myocardium enzymatic pathways with carbon-11 radiotracers.
Methods in enzymology 2004;385():286-315.
2004: Datta E Ponde; Carmen S Dence; Daniel P Schuster; Michael J Welch
Rapid and reproducible radiosynthesis of [18F] FHBG.
Nuclear medicine and biology 2004;31(1):133-8.
2003: Leonard Luyt; Heather M Bigott; Michael J Welch; John A Katzenellenbogen
7alpha- and 17alpha-substituted estrogens containing tridentate tricarbonyl rhenium/technetium complexes: synthesis of estrogen receptor imaging agents and evaluation using microPET with technetium-94m.
Bioorganic & medicinal chemistry 2003;11(23):4977-89.
2003: Carla J Mathias; Michael R Lewis; David E Reichert; Richard Laforest; Terry L Sharp; Jason S Lewis; Zhen Fan Yang; David J Waters; Paul W Snyder; Philip S Low; Michael J Welch; Mark A Green
Preparation of 66Ga- and 68Ga-labeled Ga(III)-deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticals.
Nuclear medicine and biology 2003;30(7):725-31.
2003: Michael J Welch; Jason S Lewis
[Tc(CO)(3)](+) chemistry: a promising new concept for SPECT? Against.
European journal of nuclear medicine and molecular imaging 2003;30(9):1302-4.
2003: Michael R Lewis; Mu Wang; Axworthy Don; Louis J Theodore; Robert W Mallet; Alan R Fritzberg; Michael J Welch; Carolyn J Anderson
In vivo evaluation of pretargeted 64Cu for tumor imaging and therapy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(8):1284-92.
2003: Buck E Rogers; Heather M Bigott; Deborah W McCarthy; Debbie Della Manna; Joonyoung Kim; Terry L Sharp; Michael J Welch
MicroPET imaging of a gastrin-releasing peptide receptor-positive tumor in a mouse model of human prostate cancer using a 64Cu-labeled bombesin analogue.
Bioconjugate chemistry 2003;14(4):756-63.
2003: Atsushi Obata; Shingo Kasamatsu; Deborah W McCarthy; Michael J Welch; Hideo Saji; Yoshiharu Yonekura; Yasuhisa Fujibayashi
Production of therapeutic quantities of (64)Cu using a 12 MeV cyclotron.
Nuclear medicine and biology 2003;30(5):535-9.
2003: Atsushi Obata; Mitsuyoshi Yoshimoto; Shingo Kasamatsu; Hironobu Naiki; Shinji Takamatsu; Kenichi Kashikura; Takako Furukawa; Jason S Lewis; Michael J Welch; Hideo Saji; Yoshiharu Yonekura; Yasuhisa Fujibayashi
Intra-tumoral distribution of (64)Cu-ATSM: a comparison study with FDG.
Nuclear medicine and biology 2003;30(5):529-34.
2003: Farrokh Dehdashti; Mark A Mintun; Jason S Lewis; Jeffrey Bradley; Ramaswamy Govindan; Richard Laforest; Michael J Welch; Barry A Siegel
In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM.
European journal of nuclear medicine and molecular imaging 2003;30(6):844-50.
2003: Dange Vijaykumar; Mohammed Al Qahtani; Michael J Welch; John A Katzenellenbogen
Synthesis and biological evaluation of a fluorine-18 labeled estrogen receptor-alpha selective ligand: [18F] propyl pyrazole triol.
Nuclear medicine and biology 2003;30(4):397-404.
2003: Nobuyuki Oyama; Tom R Miller; Farrokh Dehdashti; Barry A Siegel; Keith C Fischer; Jeff M Michalski; Adam S Kibel; Gerald L Andriole; Joel Picus; Michael J Welch
11C-acetate PET imaging of prostate cancer: detection of recurrent disease at PSA relapse.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(4):549-55.
2003: Farrokh Dehdashti; Perry W Grigsby; Mark A Mintun; Jason S Lewis; Barry A Siegel; Michael J Welch
Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: relationship to therapeutic response-a preliminary report.
International journal of radiation oncology, biology, physics 2003;55(5):1233-8.
2003: Jeongsoo Yoo; David E Reichert; Michael J Welch
Regioselective N-substitution of cyclen with two different alkyl groups: synthesis of all possible isomers.
Chemical communications (Cambridge, England) 2003;(6):766-7.
2003: Xiankai Sun; Melinda Wuest; Zoltan Kovacs; A Dean Sherry; Ramunas Motekaitis; Zheng Wang; Arthur E Martell; Michael J Welch; Carolyn J Anderson
In vivo behavior of copper-64-labeled methanephosphonate tetraaza macrocyclic ligands.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2003;8(1-2):217-25.
2002: Nobuyuki Oyama; Joonyoung Kim; Lynne A Jones; Nicole M Mercer; John Engelbach; Terry L Sharp; Michael J Welch
MicroPET assessment of androgenic control of glucose and acetate uptake in the rat prostate and a prostate cancer tumor model.
Nuclear medicine and biology 2002;29(8):783-90.
2002: Jason S Lewis; Pilar Herrero; Terry L Sharp; John Engelbach; Yasuhisa Fujibayashi; Richard Laforest; Attila Kovacs; Robert J Gropler; Michael J Welch
Delineation of hypoxia in canine myocardium using PET and copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone).
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2002;43(11):1557-69.
2002: Jason S Lewis; Samuel achilefu; Joel R Garbow; Richard Laforest; Michael J Welch
Small animal imaging. current technology and perspectives for oncological imaging.
European journal of cancer (Oxford, England : 1990) 2002;38(16):2173-88.
2002: Michael R Lewis; David E Reichert; Richard Laforest; William H Margenau; Ruth E Shefer; Robert E Klinkowstein; Barbara J Hughey; Michael J Welch
Production and purification of gallium-66 for preparation of tumor-targeting radiopharmaceuticals.
Nuclear medicine and biology 2002;29(6):701-6.
2002: Stephen M Moerlein; Gregory G Gaehle; Michael J Welch
Robotic preparation of Sodium Acetate C 11 Injection for use in clinical PET.
Nuclear medicine and biology 2002;29(5):613-21.
2002: Timothy J McCarthy; W A Banks; Kate Farrell; S Adamu; C P Derdeyn; Abraham Z Snyder; Richard Laforest; D C Litzinger; D Martin; C P LeBel; Michael J Welch
Positron emission tomography shows that intrathecal leptin reaches the hypothalamus in baboons.
The Journal of pharmacology and experimental therapeutics 2002;301(3):878-83.
2002: Jason L J Dearling; Jason S Lewis; Gregory E D Mullen; Michael J Welch; Philip J Blower
Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2002;7(3):249-59.
2002: Stephanie D Jonson; Michael J Welch
Investigations into tumor accumulation and peroxisome proliferator activated receptor binding by F-18 and C-11 fatty acids.
Nuclear medicine and biology 2002;29(2):211-6.
2002: Xiankai Sun; Melinda Wuest; Gary R Weisman; Edward H Wong; David P Reed; C Andrew Boswell; Ramunas Motekaitis; Arthur E Martell; Michael J Welch; Carolyn J Anderson
Radiolabeling and in vivo behavior of copper-64-labeled cross-bridged cyclam ligands.
Journal of medicinal chemistry 2002;45(2):469-77.
2002: Jason S Lewis; Judith M Connett; Joel R Garbow; Thomas L Buettner; Yasuhisa Fujibayashi; James W Fleshman; Michael J Welch
Copper-64-pyruvaldehyde-bis(N(4)-methylthiosemicarbazone) for the prevention of tumor growth at wound sites following laparoscopic surgery: monitoring therapy response with microPET and magnetic resonance imaging.
Cancer research 2002;62(2):445-9.
2002: Timothy J McCarthy; Ahmed U Sheriff; Matthew J Graneto; John J Talley; Michael J Welch
Radiosynthesis, in vitro validation, and in vivo evaluation of 18F-labeled COX-1 and COX-2 inhibitors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2002;43(1):117-24.
2002: Brian N Finck; John J Lehman; Teresa C Leone; Michael J Welch; Michael J Bennett; Attila Kovacs; Xianlin Han; Richard W Gross; Ray Kozak; Gary D Lopaschuk; Daniel P Kelly
The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.
The Journal of clinical investigation 2002;109(1):121-30.
2001: Atsushi Obata; E Yoshimi; Atsuo Waki; Jason S Lewis; N Oyama; Michael J Welch; Hideo Saji; Yoshiharu Yonekura; Yasuhisa Fujibayashi
Retention mechanism of hypoxia selective nuclear imaging/radiotherapeutic agent cu-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) in tumor cells.
Annals of nuclear medicine 2001;15(6):499-504.
2001: WB Edwards; Carolyn J Anderson; Gregg Fields; Michael J Welch
Evaluation of radiolabeled type IV collagen fragments as potential tumor imaging agents.
Bioconjugate chemistry 2001;12(6):1057-65.
2001: David E Reichert; P O Norrby; Michael J Welch
Molecular modeling of bifunctional chelate peptide conjugates. 1. Copper and indium parameters for the AMBER force field.
Inorganic chemistry 2001;40(20):5223-30.
2001: JB Downer; L A Jones; John Engelbach; L L Lich; W Mao; K E Carlson; J A Katzenellenbogen; Michael J Welch
Comparison of animal models for the evaluation of radiolabeled androgens.
Nuclear medicine and biology 2001;28(6):613-26.
2001: Noboru Takahashi; Yasuhisa Fujibayashi; Yoshiharu Yonekura; Michael J Welch; Atsuo Waki; Tatsuro Tsuchida; Norihiro Sadato; Katsuya Sugimoto; Akira Nakano; Jong-Dae Lee; Harumi Itoh
Copper-62 ATSM as a hypoxic tissue tracer in myocardial ischemia.
Annals of nuclear medicine 2001;15(3):293-6.
2001: J E Mortimer; Farrokh Dehdashti; Barry A Siegel; K Trinkaus; J A Katzenellenbogen; Michael J Welch
Metabolic flare: indicator of hormone responsiveness in advanced breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(11):2797-803.
2001: JB Downer; L A Jones; J A Katzenellenbogen; Michael J Welch
Effect of administration route on FES uptake into MCF-7 tumors.
Nuclear medicine and biology 2001;28(4):397-9.
2001: S H Kim; SD Jonson; Michael J Welch; John A Katzenellenbogen
Fluorine-substituted ligands for the peroxisome proliferator-activated receptor gamma (PPARgamma): potential imaging agents for metastatic tumors.
Bioconjugate chemistry 2001;12(3):439-50.
2001: Jason S Lewis; Terry L Sharp; Richard Laforest; Yasuhisa Fujibayashi; Michael J Welch
Tumor uptake of copper-diacetyl-bis(N(4)-methylthiosemicarbazone): effect of changes in tissue oxygenation.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2001;42(4):655-61.
2001: Mitsuyoshi Yoshimoto; Atsuo Waki; Yoshiharu Yonekura; Norihiro Sadato; T Murata; Naoto Omata; N Takahashi; Michael J Welch; Yasuhisa Fujibayashi
Characterization of acetate metabolism in tumor cells in relation to cell proliferation: acetate metabolism in tumor cells.
Nuclear medicine and biology 2001;28(2):117-22.
2000: Noboru Takahashi; Yasuhisa Fujibayashi; Yoshiharu Yonekura; Michael J Welch; Atsuo Waki; Tatsuro Tsuchida; Norihiro Sadato; Katsuya Sugimoto; Harumi Itoh
Evaluation of 62Cu labeled diacetyl-bis(N4-methylthiosemicarbazone) as a hypoxic tissue tracer in patients with lung cancer.
Annals of nuclear medicine 2000;14(5):323-8.
2000: LA Bass; Mu Wang; Michael J Welch; Carolyn J Anderson
In vivo transchelation of copper-64 from TETA-octreotide to superoxide dismutase in rat liver.
Bioconjugate chemistry 2000;11(4):527-32.
2000: CS Cutler; Melinda Wuest; Carolyn J Anderson; David E Reichert; Y Sun; Arthur E Martell; Michael J Welch
Labeling and in vivo evaluation of novel copper(II) dioxotetraazamacrocyclic complexes.
Nuclear medicine and biology 2000;27(4):375-80.
2000: Y Sun; Arthur E Martell; Joseph H Reibenspies; David E Reichert; Michael J Welch
Synthesis and characterization of racemic mixture and meso isomers of bis(trans-2-aminocyclohexyl)aminepentaacetic acid and the stabilities of their Gd(III) complexes.
Inorganic chemistry 2000;39(7):1480-6.
2000: MB Skaddan; Frank Wüst; SD Jonson; Rosemarie Syhre; Michael J Welch; Hartmut Spies; John A Katzenellenbogen
Radiochemical synthesis and tissue distribution of Tc-99m-labeled 7alpha-substituted estradiol complexes.
Nuclear medicine and biology 2000;27(3):269-78.
2000: Michael J Welch; Timothy J McCarthy
The potential role of generator-produced radiopharmaceuticals in clinical PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2000;41(2):315-7.
1999: K Shibuya; Yasuhisa Fujibayashi; E Yoshimi; K Sasai; Masahiro Hiraoka; Michael J Welch
Cytosolic/microsomal redox pathway: a reductive retention mechanism of a PET-oncology tracer, cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (cu-PTSM).
Annals of nuclear medicine 1999;13(5):287-92.
1999: DW McCarthy; LA Bass; PD Cutler; Ruth E Shefer; Robert E Klinkowstein; Pilar Herrero; Jason S Lewis; CS Cutler; Carolyn J Anderson; Michael J Welch
High purity production and potential applications of copper-60 and copper-61.
Nuclear medicine and biology 1999;26(4):351-8.
1999: CS Cutler; M C Giron; David E Reichert; A Z Snyder; Pilar Herrero; Carolyn J Anderson; D A Quarless; S A Koch; Michael J Welch
Evaluation of gallium-68 tris(2-mercaptobenzyl)amine: a complex with brain and myocardial uptake.
Nuclear medicine and biology 1999;26(3):305-16.
1999: SD Jonson; Michael J Welch
Synthesis, biological evaluation, and baboon PET imaging of the potential adrenal imaging agent cholesteryl-p-[18F]fluorobenzoate.
Nuclear medicine and biology 1999;26(1):131-8.
1999: SD Jonson; T A Bonasera; Farrokh Dehdashti; ME Cristel; John A Katzenellenbogen; Michael J Welch
Comparative breast tumor imaging and comparative in vitro metabolism of 16alpha-[18F]fluoroestradiol-17beta and 16beta-[18F]fluoromoxestrol in isolated hepatocytes.
Nuclear medicine and biology 1999;26(1):123-30.
1999: Yasuhisa Fujibayashi; CS Cutler; Carolyn J Anderson; DW McCarthy; Lynne A Jones; T Sharp; Yoshiharu Yonekura; Michael J Welch
Comparative studies of Cu-64-ATSM and C-11-acetate in an acute myocardial infarction model: ex vivo imaging of hypoxia in rats.
Nuclear medicine and biology 1999;26(1):117-21.
1999: TW Spradau; WB Edwards; Carolyn J Anderson; Michael J Welch; John A Katzenellenbogen
Synthesis and biological evaluation of Tc-99m-cyclopentadienyltricarbonyltechnetium-labeled octreotide.
Nuclear medicine and biology 1999;26(1):1-7.
1999: Jason S Lewis; DW McCarthy; Timothy J McCarthy; Yasuhisa Fujibayashi; Michael J Welch
Evaluation of 64Cu-ATSM in vitro and in vivo in a hypoxic tumor model.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1999;40(1):177-83.
1998: SD Jonson; D A d'Avignon; John A Katzenellenbogen; Michael J Welch
Methyl hypofluorite in the synthesis of 16-methoxyestradiol stereoisomers.
Steroids 1998;63(9):470-8.
1998: T M Jones-Wilson; KA Deal; Carolyn J Anderson; DW McCarthy; Z Kovacs; Ramunas Motekaitis; A Dean Sherry; Arthur E Martell; Michael J Welch
The in vivo behavior of copper-64-labeled azamacrocyclic complexes.
Nuclear medicine and biology 1998;25(6):523-30.
1998: Timothy J McCarthy; Michael J Welch
The state of positron emitting radionuclide production in 1997.
Seminars in nuclear medicine 1998;28(3):235-46.
1998: KA Deal; ME Cristel; Michael J Welch
Cellular distribution of 111In-LDTPA galactose BSA in normal and asialoglycoprotein receptor-deficient mouse liver.
Nuclear medicine and biology 1998;25(4):379-85.
1997: KA Deal; Michael J Welch
Effect of stereochemistry on the clearance mechanism of 111In(III)-labeled D- or L-benzyldiethylenetriaminepentaacetic acid.
Journal of medicinal chemistry 1997;40(24):3986-9.
1997: Stephen M Moerlein; Joel S Perlmutter; Joanne Markham; Michael J Welch
In vivo kinetics of [18F](N-methyl)benperidol: a novel PET tracer for assessment of dopaminergic D2-like receptor binding.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(8):833-45.
1997: J Zhang; M Xu; Carmen S Dence; E L Sherman; Timothy J McCarthy; Michael J Welch
Synthesis, in vivo evaluation and PET study of a carbon-11-labeled neuronal nitric oxide synthase (nNOS) inhibitor S-methyl-L-thiocitrulline.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1997;38(8):1273-8.
1997: JB Downer; T J McCarthy; WB Edwards; Carolyn J Anderson; Michael J Welch
Reactivity of p-[18F]fluorophenacyl bromide for radiolabeling of proteins and peptides.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1997;48(7):907-16.
1997: J Zhang; A H Cross; Timothy J McCarthy; Michael J Welch
Measurement of upregulation of inducible nitric oxide synthase in the experimental autoimmune encephalomyelitis model using a positron emitting radiopharmaceutical.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 1997;1(3):263-7.
1997: Carmen S Dence; CS John; Wayne D Bowen; Michael J Welch
Synthesis and evaluation of [18F] labeled benzamides: high affinity sigma receptor ligands for PET imaging.
Nuclear medicine and biology 1997;24(4):333-40.
1997: Stephen M Moerlein; Joel S Perlmutter; P D Cutler; Michael J Welch
Radiation dosimetry of [18F] (N-methyl)benperidol as determined by whole-body PET imaging of primates.
Nuclear medicine and biology 1997;24(4):311-8.
1997: John A Katzenellenbogen; Michael J Welch; F Dehdashti
The development of estrogen and progestin radiopharmaceuticals for imaging breast cancer.
Anticancer research 1997;17(3B):1573-6.
1997: E Mishani; ME Cristel; Carmen S Dence; Timothy J McCarthy; Michael J Welch
Application of a novel phenylpiperazine formation reaction to the radiosynthesis of a model fluorine-18-labeled radiopharmaceutical (18FTFMPP).
Nuclear medicine and biology 1997;24(3):269-73.
1997: T A Bonasera; SD Jonson; T S Pajeau; John A Katzenellenbogen; Michael J Welch
Retardation of 17-oxidation of 16 alpha-[18F]fluoroestradiol-17 beta by substitution of deuterium for hydrogen in the 17 alpha position(6).
Nuclear medicine and biology 1997;24(3):239-49.
1997: A W Scribner; SD Jonson; Michael J Welch; John A Katzenellenbogen
Synthesis, estrogen receptor binding, and tissue distribution of [18F]fluorodoisynolic acids.
Nuclear medicine and biology 1997;24(3):209-24.
1997: DW McCarthy; Ruth E Shefer; Robert E Klinkowstein; LA Bass; W H Margeneau; CS Cutler; Carolyn J Anderson; Michael J Welch
Efficient production of high specific activity 64Cu using a biomedical cyclotron.
Nuclear medicine and biology 1997;24(1):35-43.
1996: J Zhang; Timothy J McCarthy; W M Moore; M G Currie; Michael J Welch
Synthesis and evaluation of two positron-labeled nitric oxide synthase inhibitors, S-[11C]methylisothiourea and S-(2-[18F]fluoroethyl)isothiourea, as potential positron emission tomography tracers.
Journal of medicinal chemistry 1996;39(26):5110-8.
1996: K A Deal; R J Motekaitis; A E Martell; Michael J Welch
Evaluation of the stability and animal biodistribution of gadolinium (III) benzylamine-derivatized diethylenetriaminepentaacetic acid.
Journal of medicinal chemistry 1996;39(16):3096-3106.
1996: Timothy J McCarthy; Carmen S Dence; S W Holmberg; Joanne Markham; Daniel P Schuster; Michael J Welch
Inhaled [13N]nitric oxide: a positron emission tomography (PET) study.
Nuclear medicine and biology 1996;23(6):773-7.
1996: P Herrero; J J Hartman; M A Green; Carolyn J Anderson; Michael J Welch; Joanne Markham; Steven Bergmann
Regional myocardial perfusion assessed with generator-produced copper-62-PTSM and PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1996;37(8):1294-300.
1996: Buck E Rogers; Carolyn J Anderson; Judith M Connett; L W Guo; WB Edwards; E L Sherman; K R Zinn; Michael J Welch
Comparison of four bifunctional chelates for radiolabeling monoclonal antibodies with copper radioisotopes: biodistribution and metabolism.
Bioconjugate chemistry 1996;7(4):511-22.
1996: Judith M Connett; Carolyn J Anderson; L W Guo; Sally W Schwarz; K R Zinn; Buck E Rogers; Barry A Siegel; G W Philpott; Michael J Welch
Radioimmunotherapy with a 64Cu-labeled monoclonal antibody: a comparison with 67Cu.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6814-8.
1996: J E Mortimer; Farrokh Dehdashti; Barry A Siegel; John A Katzenellenbogen; P Fracasso; Michael J Welch
Positron emission tomography with 2-[18F]Fluoro-2-deoxy-D-glucose and 16alpha-[18F]fluoro-17beta-estradiol in breast cancer: correlation with estrogen receptor status and response to systemic therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(6):933-9.
1996: T A Bonasera; James P O'Neil; M Xu; J A Dobkin; PD Cutler; L L Lich; Y S Choe; John A Katzenellenbogen; Michael J Welch
Preclinical evaluation of fluorine-18-labeled androgen receptor ligands in baboons.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1996;37(6):1009-15.
1996: Carmen S Dence; E Napolitano; John A Katzenellenbogen; Michael J Welch
Carbon-11-labeled estrogens as potential imaging agents for breast tumors.
Nuclear medicine and biology 1996;23(4):491-6.
1996: Y Sun; Carolyn J Anderson; T S Pajeau; D E Reichert; R D Hancock; R J Motekaitis; A E Martell; Michael J Welch
Indium (III) and gallium (III) complexes of bis(aminoethanethiol) ligands with different denticities: stabilities, molecular modeling, and in vivo behavior.
Journal of medicinal chemistry 1996;39(2):458-70.
1995: PD Cutler; Sally W Schwarz; Carolyn J Anderson; Judith M Connett; Michael J Welch; G W Philpott; Barry A Siegel
Dosimetry of copper-64-labeled monoclonal antibody 1A3 as determined by PET imaging of the torso.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(12):2363-71.
1995: Carolyn J Anderson; T S Pajeau; WB Edwards; E L Sherman; Buck E Rogers; Michael J Welch
In vitro and in vivo evaluation of copper-64-octreotide conjugates.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(12):2315-25.
1995: Buck E Rogers; F N Franano; J R Duncan; WB Edwards; Carolyn J Anderson; Judith M Connett; Michael J Welch
Identification of metabolites of 111In-diethylenetriaminepentaacetic acid-monoclonal antibodies and antibody fragments in vivo.
Cancer research 1995;55(23 Suppl):5714s-5720s.
1995: T M Jones-Wilson; R J Motekaitis; Y Sun; Carolyn J Anderson; A E Martell; Michael J Welch
New hydroxybenzyl and hydroxypyridylmethyl substituted triazacyclononane ligands for use with gallium(III) and indium(III).
Nuclear medicine and biology 1995;22(7):859-68.
1995: G W Philpott; Sally W Schwarz; Carolyn J Anderson; Farrokh Dehdashti; Judith M Connett; K R Zinn; Claude F Meares; PD Cutler; Michael J Welch; Barry A Siegel
RadioimmunoPET: detection of colorectal carcinoma with positron-emitting copper-64-labeled monoclonal antibody.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(10):1818-24.
1995: Farrokh Dehdashti; J E Mortimer; Barry A Siegel; L K Griffeth; T J Bonasera; M J Fusselman; D D Detert; PD Cutler; John A Katzenellenbogen; Michael J Welch
Positron tomographic assessment of estrogen receptors in breast cancer: comparison with FDG-PET and in vitro receptor assays.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(10):1766-74.
1995: Stephen M Moerlein; Joel S Perlmutter; Michael J Welch
Specific, reversible binding of [18F]benperidol to baboon D2 receptors: PET evaluation of an improved 18F-labeled ligand.
Nuclear medicine and biology 1995;22(6):809-15.
1995: Y S Choe; T A Bonasera; Dae Yoon Chi; Michael J Welch; John A Katzenellenbogen
6 alpha-[18F]fluoroprogesterone: synthesis via halofluorination-oxidation, receptor binding and tissue distribution.
Nuclear medicine and biology 1995;22(5):635-42.
1995: Y S Choe; P J Lidström; Dae Yoon Chi; T A Bonasera; Michael J Welch; John A Katzenellenbogen
Synthesis of 11 beta-[18F]fluoro-5 alpha-dihydrotestosterone and 11 beta-[18F]fluoro-19-nor-5 alpha-dihydrotestosterone: preparation via halofluorination-reduction, receptor binding, and tissue distribution.
Journal of medicinal chemistry 1995;38(5):816-25.
1995: Daniel P Schuster; J D Kaplan; K Gauvain; Michael J Welch; Joanne Markham
Measurement of regional pulmonary blood flow with PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(3):371-7.
1995: Daniel P Schuster; Timothy J McCarthy; Michael J Welch; S Holmberg; P Sandiford; Joanne Markham
In vivo measurements of pulmonary angiotensin-converting enzyme kinetics. II. Implementation and application.
Journal of applied physiology (Bethesda, Md. : 1985) 1995;78(3):1169-78.
1995: Joanne Markham; Timothy J McCarthy; Michael J Welch; Daniel P Schuster
In vivo measurements of pulmonary angiotensin-converting enzyme kinetics. I. Theory and error analysis.
Journal of applied physiology (Bethesda, Md. : 1985) 1995;78(3):1158-68.
1995: Carolyn J Anderson; C S John; Y J Li; R D Hancock; Timothy J McCarthy; A E Martell; Michael J Welch
N,N'-ethylene-di-L-cysteine (EC) complexes of Ga(III) and In(III): molecular modeling, thermodynamic stability and in vivo studies.
Nuclear medicine and biology 1995;22(2):165-73.
1995: Brad Buckman; T A Bonasera; K S Kirschbaum; Michael J Welch; John A Katzenellenbogen
Fluorine-18-labeled progestin 16 alpha, 17 alpha-dioxolanes: development of high-affinity ligands for the progesterone receptor with high in vivo target site selectivity.
Journal of medicinal chemistry 1995;38(2):328-37.
1995: F N Franano; WB Edwards; Michael J Welch; M W Brechbiel; Otto A Gansow; J R Duncan
Biodistribution and metabolism of targeted and nontargeted protein-chelate-gadolinium complexes: evidence for gadolinium dissociation in vitro and in vivo.
Magnetic resonance imaging 1995;13(2):201-14.
1994: F N Franano; WB Edwards; Michael J Welch; J R Duncan
Metabolism of receptor targeted 111In-DTPA-glycoproteins: identification of 111In-DTPA-epsilon-lysine as the primary metabolic and excretory product.
Nuclear medicine and biology 1994;21(8):1023-34.
1994: WB Edwards; C G Fields; Carolyn J Anderson; T S Pajeau; Michael J Welch; Gregg Fields
Generally applicable, convenient solid-phase synthesis and receptor affinities of octreotide analogs.
Journal of medicinal chemistry 1994;37(22):3749-57.
1994: Carmen S Dence; Michael J Welch; B J Hughey; Ruth E Shefer; Robert E Klinkowstein
Production of [13N]ammonia applicable to low energy accelerators.
Nuclear medicine and biology 1994;21(7):987-96.
1994: Ruth E Shefer; B J Hughey; Robert E Klinkowstein; Michael J Welch; Carmen S Dence
A windowless 13N production target for use with low energy deuteron accelerators.
Nuclear medicine and biology 1994;21(7):977-86.
1994: Brad Buckman; Henry VanBrocklin; C S Dence; Steven Bergmann; Michael J Welch; John A Katzenellenbogen
Synthesis and tissue biodistribution of [omega-11C]palmitic acid. A novel PET imaging agent for cardiac fatty acid metabolism.
Journal of medicinal chemistry 1994;37(15):2481-5.
1994: J R Duncan; F N Franano; WB Edwards; Michael J Welch
Evidence of gadolinium dissociation from protein-DTPA-gadolinium complexes.
Investigative radiology 1994;29 Suppl 2():S58-61.
1994: Sally W Schwarz; Judith M Connett; Carolyn J Anderson; P A Rocque; G W Philpott; L W Guo; Michael J Welch
Evaluation of a direct method for technetium labeling intact and F(ab')2 1A3, an anticolorectal monoclonal antibody.
Nuclear medicine and biology 1994;21(4):619-26.
1994: James P O'Neil; Kathryn E Carlson; Carolyn J Anderson; Michael J Welch; John A Katzenellenbogen
Progestin radiopharmaceuticals labeled with technetium and rhenium: synthesis, binding affinity, and in vivo distribution of a new progestin N2S2-metal conjugate.
Bioconjugate chemistry 1994;5(3):182-93.
1994: Dae Yoon Chi; James P O'Neil; Carolyn J Anderson; Michael J Welch; John A Katzenellenbogen
Homodimeric and heterodimeric bis(amino thiol) oxometal complexes with rhenium(V) and technetium(V). Control of heterodimeric complex formation and an approach to metal complexes that mimic steroid hormones.
Journal of medicinal chemistry 1994;37(7):928-37.
1994: K E Bergmann; S W Landvatter; P G Rocque; Kathryn E Carlson; Michael J Welch; John A Katzenellenbogen
Oxohexestrol derivatives labeled with fluorine-18. Synthesis, receptor binding and in vivo distribution of two non-steroidal estrogens as potential breast tumor imaging agents.
Nuclear medicine and biology 1994;21(1):25-39.
1994: Henry VanBrocklin; A Liu; Michael J Welch; James P O'Neil; John A Katzenellenbogen
The synthesis of 7 alpha-methyl-substituted estrogens labeled with fluorine-18: potential breast tumor imaging agents.
Steroids 1994;59(1):34-45.
1993: Stephen M Moerlein; G G Gaehle; K R Lechner; R K Bera; Michael J Welch
Automated production of oxygen-15 labeled butanol for PET measurement of regional cerebral blood flow.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1993;44(9):1213-8.
1993: John A Katzenellenbogen; C J Mathias; Henry VanBrocklin; J W Brodack; Michael J Welch
Titration of the in vivo uptake of 16 alpha-[18F]fluoroestradiol by target tissues in the rat: competition by tamoxifen, and implications for quantitating estrogen receptors in vivo and the use of animal models in receptor-binding radiopharmaceutical development.
Nuclear medicine and biology 1993;20(6):735-45.
1993: Timothy J McCarthy; Carmen S Dence; Michael J Welch
Application of microwave heating to the synthesis of [18F]fluoromisonidazole.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1993;44(8):1129-32.
1993: Carmen S Dence; Timothy J McCarthy; Michael J Welch
Improved synthesis of [18F]4-fluorophenacyl bromide: the use of polymer supported perbromide.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1993;44(6):981-3.
1993: Carmen S Dence; William Powers; Michael J Welch
Improved synthesis of 1-[11C]D-glucose.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1993;44(6):971-80.
1993: Henry VanBrocklin; Kathryn E Carlson; John A Katzenellenbogen; Michael J Welch
16 beta-([18F]fluoro)estrogens: systematic investigation of a new series of fluorine-18-labeled estrogens as potential imaging agents for estrogen-receptor-positive breast tumors.
Journal of medicinal chemistry 1993;36(11):1619-29.
1993: Carolyn J Anderson; P A Rocque; C J Weinheimer; Michael J Welch
Evaluation of copper-labeled bifunctional chelate-albumin conjugates for blood pool imaging.
Nuclear medicine and biology 1993;20(4):461-7.
1993: M J Kochanny; Henry VanBrocklin; P R Kym; Kathryn E Carlson; James P O'Neil; T A Bonasera; Michael J Welch; John A Katzenellenbogen
Fluorine-18-labeled progestin ketals: synthesis and target tissue uptake selectivity of potential imaging agents for receptor-positive breast tumors.
Journal of medicinal chemistry 1993;36(9):1120-7.
1993: A N French; S R Wilson; Michael J Welch; John A Katzenellenbogen
A synthesis of 7 alpha-substituted estradiols: synthesis and biological evaluation of a 7 alpha-pentyl-substituted BODIPY fluorescent conjugate and a fluorine-18-labeled 7 alpha-pentylestradiol analog.
Steroids 1993;58(4):157-69.
1993: S M Moerlein; R A Weisman; D Beck; Albert P Li; Michael J Welch
Metabolism in vitro of radioiodinated N-isopropyl-p-iodoamphetamine by isolated hepatocytes.
Nuclear medicine and biology 1993;20(1):49-56.
1993: A N French; Elio Napolitano; Henry VanBrocklin; Robert N Hanson; Michael J Welch; John A Katzenellenbogen
Synthesis, radiolabeling and tissue distribution of 11 beta-fluoroalkyl- and 11 beta-fluoroalkoxy-substituted estrogens: target tissue uptake selectivity and defluorination of a homologous series of fluorine-18-labeled estrogens.
Nuclear medicine and biology 1993;20(1):31-47.
1993: P Herrero; Joanne Markham; C J Weinheimer; Carolyn J Anderson; Michael J Welch; M A Green; Steven Bergmann
Quantification of regional myocardial perfusion with generator-produced 62Cu-PTSM and positron emission tomography.
Circulation 1993;87(1):173-83.
1993: Henry VanBrocklin; P A Rocque; H V Lee; Kathryn E Carlson; John A Katzenellenbogen; Michael J Welch
16 beta-[18F]fluoromoxestrol: a potent, metabolically stable positron emission tomography imaging agent for estrogen receptor positive human breast tumors.
Life sciences 1993;53(10):811-9.
1992: Carolyn J Anderson; Judith M Connett; Sally W Schwarz; P A Rocque; L W Guo; G W Philpott; K R Zinn; Claude F Meares; Michael J Welch
Copper-64-labeled antibodies for PET imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992;33(9):1685-91.
1992: J P DiZio; Kathryn E Carlson; C J Bannochie; Michael J Welch; E Von Angerer; John A Katzenellenbogen
Estrogen platinum-diamine complexes: preparation of a non-steroidal estrogen platinum-diamine complex labeled with platinum-191 and a study of its binding to the estrogen receptor in vitro and its tissue distribution in vivo.
The Journal of steroid biochemistry and molecular biology 1992;42(3-4):363-73.
1992: A Liu; C S Dence; Michael J Welch; John A Katzenellenbogen
Fluorine-18-labeled androgens: radiochemical synthesis and tissue distribution studies on six fluorine-substituted androgens, potential imaging agents for prostatic cancer.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992;33(5):724-34.
1992: Martin G Pomper; M J Kochanny; A M Thieme; Kathryn E Carlson; Henry VanBrocklin; C J Mathias; Michael J Welch; John A Katzenellenbogen
Fluorine-substituted corticosteroids: synthesis and evaluation as potential receptor-based imaging agents for positron emission tomography of the brain.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1992;19(4):461-80.
1992: S L Madsen; Michael J Welch; R J Motekaitis; A E Martell
68GaTHM2BED: a potential generator-produced tracer of myocardial perfusion for positron emission tomography.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1992;19(4):431-44.
1992: Henry VanBrocklin; Martin G Pomper; Kathryn E Carlson; Michael J Welch; John A Katzenellenbogen
Preparation and evaluation of 17-ethynyl-substituted 16 alpha-[18F]fluoroestradiols: selective receptor-based PET imaging agents.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1992;19(3):363-74.
1992: J P DiZio; Carolyn J Anderson; A Davison; G J Ehrhardt; Kathryn E Carlson; Michael J Welch; John A Katzenellenbogen
Technetium- and rhenium-labeled progestins: synthesis, receptor binding and in vivo distribution of an 11 beta-substituted progestin labeled with technetium-99 and rhenium-186.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992;33(4):558-69.
1992: C B Wiegers; Michael J Welch; T L Sharp; J J Brown; W H Perman; Y Sun; R J Motekaitis; A E Martell
Evaluation of two new gadolinium chelates as contrast agents for MRI.
Magnetic resonance imaging 1992;10(6):903-11.
1991: Richard S Hotchkiss; R S Rust; Carmen S Dence; T H Wasserman; Sheng-Kwei Song; D R Hwang; Irene E Karl; Michael J Welch
Evaluation of the role of cellular hypoxia in sepsis by the hypoxic marker [18F]fluoromisonidazole.
The American journal of physiology 1991;261(4 Pt 2):R965-72.
1991: D R Hwang; William Eckelman; C J Mathias; E W Petrillo; J Lloyd; Michael J Welch
Positron-labeled angiotensin-converting enzyme (ACE) inhibitor: fluorine-18-fluorocaptopril. Probing the ACE activity in vivo by positron emission tomography.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1991;32(9):1730-7.
1991: Farrokh Dehdashti; A H McGuire; H F Van Brocklin; Barry A Siegel; D P Andriole; L K Griffeth; Martin G Pomper; John A Katzenellenbogen; Michael J Welch
Assessment of 21-[18F]fluoro-16 alpha-ethyl-19-norprogesterone as a positron-emitting radiopharmaceutical for the detection of progestin receptors in human breast carcinomas.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1991;32(8):1532-7.
1991: A H McGuire; Farrokh Dehdashti; Barry A Siegel; A P Lyss; J W Brodack; C J Mathias; M A Mintun; John A Katzenellenbogen; Michael J Welch
Positron tomographic assessment of 16 alpha-[18F] fluoro-17 beta-estradiol uptake in metastatic breast carcinoma.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1991;32(8):1526-31.
1991: Y Sun; C J Mathias; Michael J Welch; S L Madsen; A E Martell
Targeting radiopharmaceuticals--II. Evaluation of new trivalent metal complexes with different overall charges.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1991;18(3):323-30.
1991: S L Madsen; C J Bannochie; Michael J Welch; C J Mathias; A E Martell
TMPHPG: a lipophilic derivative of EHPG for iron, gallium-68 and indium-111 hepatobiliary clearance.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1991;18(3):289-94.
1991: D R Hwang; Carmen S Dence; Z A McKinnon; C J Mathias; Michael J Welch
Positron labeled muscarinic acetylcholine receptor antagonist: 2- and 4-[18F]fluorodexetimide. Syntheses and biodistribution.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1991;18(2):247-52.
1991: A J Liu; John A Katzenellenbogen; Henry VanBrocklin; C J Mathias; Michael J Welch
20-[18F]fluoromibolerone, a positron-emitting radiotracer for androgen receptors: synthesis and tissue distribution studies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1991;32(1):81-8.
1991: Sally W Schwarz; C J Mathias; J Y Sun; W G Dilley; S A Wells; A E Martell; Michael J Welch
Evaluation of two new bifunctional chelates for radiolabeling a parathyroid-specific monoclonal antibody with In-111.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1991;18(5):477-81.
1991: F L Otsuka; Michael J Welch; Michael R Kilbourn; Carmen S Dence; W G Dilley; S A Wells
Antibody fragments labeled with fluorine-18 and gallium-68: in vivo comparison with indium-111 and iodine-125-labeled fragments.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1991;18(7):813-6.
1991: C J Mathias; Michael J Welch; D J Perry; A H McGuire; X Zhu; Judith M Connett; M A Green
Investigation of copper-PTSM as a PET tracer for tumor blood flow.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1991;18(7):807-11.
1991: D R Hwang; Carmen S Dence; J L Gong; Michael J Welch
A new procedure for labeling alkylbenzenes with [18F]fluoride.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1991;42(11):1043-7.
1991: Michael J Welch; C J Mathias; A McGuire
Positron emission tomography. Present status and future prospectives.
Acta radiologica. Supplementum 1991;376():24-30.
1991: C J Mathias; W H Margenau; J W Brodack; Michael J Welch; M A Green
A remote system for the synthesis of copper-62 labeled Cu(PTSM).
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1991;42(3):317-20.
1990: Martin G Pomper; Henry VanBrocklin; A M Thieme; R D Thomas; D O Kiesewetter; Kathryn E Carlson; C J Mathias; Michael J Welch; John A Katzenellenbogen
11 beta-methoxy-, 11 beta-ethyl- and 17 alpha-ethynyl-substituted 16 alpha-fluoroestradiols: receptor-based imaging agents with enhanced uptake efficiency and selectivity.
Journal of medicinal chemistry 1990;33(12):3143-55.
1990: A E Martell; Michael J Welch; R J Motekaitis
A new radiochemical method to determine the stability constants of metal chelates attached to a protein.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990;31(10):1744-6.
1990: S L Madsen; C J Bannochie; A E Martell; C J Mathias; Michael J Welch
Investigation of physicochemical and in-vivo behavior of diastereomeric iron-59, gallium-68, and indium-111-EHPG trivalent metal complexes.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990;31(10):1662-8.
1990: M E Shelton; M A Green; C J Mathias; Michael J Welch; Steven Bergmann
Assessment of regional myocardial and renal blood flow with copper-PTSM and positron emission tomography.
Circulation 1990;82(3):990-7.
1990: M E Shelton; Carmen S Dence; D R Hwang; P Herrero; Michael J Welch; Steven Bergmann
In vivo delineation of myocardial hypoxia during coronary occlusion using fluorine-18 fluoromisonidazole and positron emission tomography: a potential approach for identification of jeopardized myocardium.
Journal of the American College of Cardiology 1990;16(2):477-85.
1990: S S Pochapsky; Henry VanBrocklin; Michael J Welch; John A Katzenellenbogen
Synthesis and tissue distribution of fluorine-18 labeled trifluorohexadecanoic acids. Considerations in the development of metabolically blocked myocardial imaging agents.
Bioconjugate chemistry 1990;1(4):231-44.
1990: P L Chesis; D R Hwang; Michael J Welch
N-(3-[18F]fluoropropyl)-N-nordiprenorphine: synthesis and characterization of a new agent for imaging opioid receptors with positron emission tomography.
Journal of medicinal chemistry 1990;33(5):1482-90.
1990: C J Mathias; Y Z Sun; Michael J Welch; Judith M Connett; G W Philpott; A E Martell
N,N'-bis(2-hydroxybenzyl)-1-(4-bromoacetamidobenzyl)-1,2 -ethylenediamine-N,N'-diacetic acid: a new bifunctional chelate for radiolabeling antibodies.
Bioconjugate chemistry 1990;1(3):204-11.
1990: C J Mathias; Michael J Welch; Marcus E Raichle; M A Mintun; L L Lich; A H McGuire; K R Zinn; E K John; M A Green
Evaluation of a potential generator-produced PET tracer for cerebral perfusion imaging: single-pass cerebral extraction measurements and imaging with radiolabeled Cu-PTSM.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990;31(3):351-9.
1990: P L Chesis; L K Griffeth; C J Mathias; Michael J Welch
Sex-dependent differences in N-(3-[18F]fluoropropyl)-N-nordiprenorphine biodistribution and metabolism.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990;31(2):192-201.
1990: Martin G Pomper; K G Pinney; Kathryn E Carlson; H van Brocklin; C J Mathias; Michael J Welch; John A Katzenellenbogen
Target tissue uptake selectivity of three fluorine-substituted progestins: potential imaging agents for receptor-positive breast tumors.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1990;17(3):309-19.
1990: D R Hwang; C J Mathias; Michael J Welch; A H McGuire; D Kadmon
Imaging prostate derived tumors with PET and N-(3-[18F]fluoropropyl)putrescine.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1990;17(6):525-32.
1990: Stephen M Moerlein; D Parkinson; Michael J Welch
Radiosynthesis of high effective specific-activity [123I]SCH 23982 for dopamine D-1 receptor-based SPECT imaging.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1990;41(4):381-5.
1990: P L Chesis; Michael J Welch
Synthesis and in vitro characterization of fluorinated U-50488 analogs for PET studies of kappa opioid receptors.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1990;41(3):267-73.
1990: P L Chesis; Michael J Welch
Comparison of bromo- and iodoalkyl triflates for 18F-radiolabeling of amines.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1990;41(3):259-65.
1990: Stephen M Moerlein; G S Lannoye; Michael J Welch
No-carrier-added radiosynthesis of [123I]HIPDM: N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-[123I] iodobenzyl)-1,3-propanediamine.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1990;41(3):253-7.
1990: Michael J Welch
Potential of labeling monoclonal antibodies for positron emission tomography and magnetic resonance imaging.
Acta radiologica. Supplementum 1990;374():129-33.
1990: Henry VanBrocklin; J W Brodack; C J Mathias; Michael J Welch; John A Katzenellenbogen; J F Keenan; G J Mizejewski
Binding of 16 alpha-[18F]fluoro-17 beta-estradiol to alphafetoprotein in Sprague-Dawley female rats affects blood levels.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1990;17(8):769-73.
1989: M E Shelton; M A Green; C J Mathias; Michael J Welch; Steven Bergmann
Kinetics of copper-PTSM in isolated hearts: a novel tracer for measuring blood flow with positron emission tomography.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1989;30(11):1843-7.
1989: D R Hwang; L X Lang; C J Mathias; D Kadmon; Michael J Welch
N-3-[18F]fluoropropylputrescine as potential PET imaging agent for prostate and prostate derived tumors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1989;30(7):1205-10.
1989: M E Shelton; Carmen S Dence; D R Hwang; Michael J Welch; Steven Bergmann
Myocardial kinetics of fluorine-18 misonidazole: a marker of hypoxic myocardium.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1989;30(3):351-8.
1989: C J Mathias; Michael J Welch; D B Schwartz; S M Spaethe; P Needleman
Differentiation in vivo of the sequential blood cell invasion following ureter obstruction of the rabbit kidney.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1989;16(1):25-32.
1989: Stephen M Moerlein; J W Brodack; Barry A Siegel; Michael J Welch
Elimination of contaminant Kryptofix 2.2.2 in the routine production of 2-[18F]fluoro-2-deoxy-D-glucose.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1989;40(9):741-3.
1989: D R Hwang; Carmen S Dence; T A Bonasera; Michael J Welch
No-carrier-added synthesis of 3-[18F]fluoro-1-(2-nitro-1-imidazolyl)-2-propanol. A potential PET agent for detecting hypoxic but viable tissues.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1989;40(2):117-26.
1988: M A Mintun; Michael J Welch; Barry A Siegel; C J Mathias; J W Brodack; A H McGuire; John A Katzenellenbogen
Breast cancer: PET imaging of estrogen receptors.
Radiology 1988;169(1):45-8.
1988: Martin G Pomper; John A Katzenellenbogen; Michael J Welch; J W Brodack; C J Mathias
21-[18F]fluoro-16 alpha-ethyl-19-norprogesterone: synthesis and target tissue selective uptake of a progestin receptor based radiotracer for positron emission tomography.
Journal of medicinal chemistry 1988;31(7):1360-3.
1988: F L Otsuka; William G Cance; W G Dilley; R W Scott; J M Davie; S A Wells; Michael J Welch
A potential new radiopharmaceutical for parathyroid imaging: radiolabeled parathyroid-specific monoclonal antibody--II. Comparison of 125I- and 111In-labeled antibodies.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1988;15(3):305-11.
1988: William G Cance; F L Otsuka; W G Dilley; R W Scott; J M Davie; Michael J Welch; S A Wells
A potential new radiopharmaceutical for parathyroid imaging: radiolabeled parathyroid-specific monoclonal antibody--I. Evaluation of 125I-labeled antibody in a nude mouse model system.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1988;15(3):299-303.
1988: Michael J Welch; John A Katzenellenbogen; C J Mathias; J W Brodack; Kathryn E Carlson; Dae Yoon Chi; Carmen S Dence; Michael R Kilbourn; J S Perlmutter; M E Raichle
N-(3-[18F]fluoropropyl)-spiperone: the preferred 18F labeled spiperone analog for positron emission tomographic studies of the dopamine receptor.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1988;15(1):83-97.
1988: C J Mathias; Y Z Sun; Michael J Welch; M A Green; J A Thomas; K R Wade; A E Martell
Targeting radiopharmaceuticals: comparative biodistribution studies of gallium and indium complexes of multidentate ligands.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1988;15(1):69-81.
1988: J W Brodack; Carmen S Dence; Michael R Kilbourn; Michael J Welch
Robotic production of 2-deoxy-2-[18F]fluoro-D-glucose: a routine method of synthesis using tetrabutylammonium [18F]fluoride.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1988;39(7):699-703.
1988: J W Brodack; Michael R Kilbourn; Michael J Welch
Automated production of several positron-emitting radiopharmaceuticals using a single laboratory robot.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1988;39(7):689-98.
1988: Stephen M Moerlein; D R Hwang; Michael J Welch
No-carrier-added radiobromination via cuprous chloride-assisted nucleophilic aromatic bromodeiodination.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1988;39(5):369-72.
1987: M A Mintun; D R Dennis; Michael J Welch; C J Mathias; Daniel P Schuster
Measurements of pulmonary vascular permeability with PET and gallium-68 transferrin.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1987;28(11):1704-16.
1987: C J Mathias; Michael J Welch; Michael R Kilbourn; P A Jerabek; T B Patrick; M E Raichle; K A Krohn; J S Rasey; D W Shaw
Radiolabeled hypoxic cell sensitizers: tracers for assessment of ischemia.
Life sciences 1987;41(2):199-206.
1987: F L Otsuka; Michael J Welch
Methods to label monoclonal antibodies for use in tumor imaging.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1987;14(3):243-9.
1987: C J Mathias; Michael J Welch; John A Katzenellenbogen; J W Brodack; Michael R Kilbourn; Kathryn E Carlson; D O Kiesewetter
Characterization of the uptake of 16 alpha-([18F]fluoro)-17 beta-estradiol in DMBA-induced mammary tumors.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1987;14(1):15-25.
1986: William G Cance; S A Wells; W G Dilley; Michael J Welch; F L Otsuka; J M Davie
Human parathyroid antigen: characterization and localization with monoclonal antibodies.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(16):6112-6.
1986: Michael J Welch; Dae Yoon Chi; C J Mathias; Michael R Kilbourn; J W Brodack; John A Katzenellenbogen
Biodistribution of N-alkyl and N-fluoroalkyl derivatives of spiroperidol; radiopharmaceuticals for PET studies of dopamine receptors.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1986;13(5):523-6.
1986: Dae Yoon Chi; Michael R Kilbourn; John A Katzenellenbogen; J W Brodack; Michael J Welch
Synthesis of no-carrier-added N-([18F]fluoroalkyl)spiperone derivatives.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1986;37(12):1173-80.
1986: D R Hwang; P A Jerabek; D Kadmon; Michael R Kilbourn; T B Patrick; Michael J Welch
2-[18F]fluoroputrescine: preparation, biodistribution, and mechanism of defluorination.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1986;37(7):607-12.
1986: P A Jerabek; T B Patrick; Michael R Kilbourn; D D Dischino; Michael J Welch
Synthesis and biodistribution of 18F-labeled fluoronitroimidazoles: potential in vivo markers of hypoxic tissue.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1986;37(7):599-605.
1985: P A Jerabek; C S Dence; Michael R Kilbourn; Michael J Welch; D Kadmon
Synthesis and uptake of no-carrier-added 1-[11C]putrescine into rat prostate.
International journal of nuclear medicine and biology 1985;12(5):349-52.
1983: K D McElvany; Kathryn E Carlson; John A Katzenellenbogen; Michael J Welch
Factors affecting the target site uptake selectivity of estrogen radiopharmaceuticals: serum binding and endogenous estrogens.
Journal of steroid biochemistry 1983;18(6):635-41.
1982: S W Landvatter; John A Katzenellenbogen; K D McElvany; Michael J Welch
(2R*,3S*)-1-[125I]Iodo-2,3-bis(4-hydroxyphenyl)pentane ([125I]iodonorhexestrol) and (2R*,3S*)-1-[77Br]Bromo-2,3-bis(4-hydroxyphenyl)pentane ([77Br]bromonorhexestrol), two gamma-emitting estrogens that show receptor-mediated uptake by target tissues in vivo.
Journal of medicinal chemistry 1982;25(11):1307-12.
1982: S G Senderoff; K D McElvany; Kathryn E Carlson; D F Heiman; John A Katzenellenbogen; Michael J Welch
Methodology for the synthesis and specific activity determination of 16 alpha-[77Br]-bromoestradiol-17 beta and 16 alpha-[77Br]-11 beta-methoxyestradiol-17 beta, two estrogen receptor-binding radiopharmaceuticals.
The International journal of applied radiation and isotopes 1982;33(7):545-51.
1982: K D McElvany; John A Katzenellenbogen; K E Shafer; B A Siegel; S G Senderoff; Michael J Welch
16 alpha-[77Br]bromoestradiol: dosimetry and preliminary clinical studies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1982;23(5):425-30.
1982: K D McElvany; Kathryn E Carlson; Michael J Welch; S G Senderoff; John A Katzenellenbogen
In vivo comparison of 16 alpha[77Br]bromoestradiol-17 beta and 16 alpha-[125I]iodoestradiol-17 beta.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1982;23(5):420-4.
1982: John A Katzenellenbogen; K D McElvany; S G Senderoff; Kathryn E Carlson; S W Landvatter; Michael J Welch
16 alpha-[77Br]bromo-11 beta-methoxyestradiol-17 beta: a gamma-emitting estrogen imaging agent with high uptake and retention by target organs.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1982;23(5):411-9.
1981: John A Katzenellenbogen; S G Senderoff; K D McElvany; H A O'Brien; Michael J Welch
16 alpha-[77Br]bromoestradiol-17 beta: a high specific-activity, gamma-emitting tracer with uptake in rat uterus and uterus and induced mammary tumors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1981;22(1):42-7.