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Howard Welgus
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Chemicals & Drugs
Anatomy
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19
Parks, William
16
Senior, Robert
12
Shapiro, SD
6
Pilcher, BK
6
Sudbeck, BD
4
Roswit, William
4
Mecham, Robert
3
Griffin, Gail
3
Baragi, VM
3
Broekelmann, Thomas
3
Dumin, JA
3
Gluck, Stephen
3
Shipley, Michael
2
Schmid, Thomas
2
Holliday, Shannon
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Geonetwork of Howard Welgus (preview)
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All Publications
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2003: Holliday L S; Welgus H G; Hanna J; Lee B S; Lu M; Jeffrey J J; Gluck S L
Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts.
Calcified tissue international 2003;72(3):206-14.
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2002: Mohan Royce; Chintala Shravan K; Jung Jae Chang; Villar Winston V L; McCabe Frank; Russo Laoti A; Lee Yunhee; McCarthy Brendan E; Wollenberg Kurt R; Jester James V; Wang Min; Welgus Howard G; Shipley J Michael; Senior Robert M; Fini M Elizabeth
Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration.
The Journal of biological chemistry 2002;277(3):2065-72.
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1999: Pilcher B K; Wang M; Qin X J; Parks W C; Senior R M; Welgus H G
Role of matrix metalloproteinases and their inhibition in cutaneous wound healing and allergic contact hypersensitivity.
Annals of the New York Academy of Sciences 1999;878():12-24.
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1999: Wang M; Qin X; Mudgett J S; Ferguson T A; Senior R M; Welgus H G
Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6885-9.
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1999: Pilcher B K; Dumin J; Schwartz M J; Mast B A; Schultz G S; Parks W C; Welgus H G
Keratinocyte collagenase-1 expression requires an epidermal growth factor receptor autocrine mechanism.
The Journal of biological chemistry 1999;274(15):10372-81.
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1998: Dunsmore S E; Saarialho-Kere U K; Roby J D; Wilson C L; Matrisian L M; Welgus H G; Parks W C
Matrilysin expression and function in airway epithelium.
The Journal of clinical investigation 1998;102(7):1321-31.
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1998: Pilcher B K; Sudbeck B D; Dumin J A; Welgus H G; Parks W C
Collagenase-1 and collagen in epidermal repair.
Archives of dermatological research 1998;290 Suppl():S37-46.
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1997: Sudbeck B D; Pilcher B K; Welgus H G; Parks W C
Induction and repression of collagenase-1 by keratinocytes is controlled by distinct components of different extracellular matrix compartments.
The Journal of biological chemistry 1997;272(35):22103-10.
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1997: Holliday L S; Welgus H G; Fliszar C J; Veith G M; Jeffrey J J; Gluck S L
Initiation of osteoclast bone resorption by interstitial collagenase.
The Journal of biological chemistry 1997;272(35):22053-8.
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1997: Pilcher B K; Gaither-Ganim J; Parks W C; Welgus H G
Cell type-specific inhibition of keratinocyte collagenase-1 expression by basic fibroblast growth factor and keratinocyte growth factor. A common receptor pathway.
The Journal of biological chemistry 1997;272(29):18147-54.
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1997: Mecham R P; Broekelmann T J; Fliszar C J; Shapiro S D; Welgus H G; Senior R M
Elastin degradation by matrix metalloproteinases. Cleavage site specificity and mechanisms of elastolysis.
The Journal of biological chemistry 1997;272(29):18071-6.
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1997: Pilcher B K; Dumin J A; Sudbeck B D; Krane S M; Welgus H G; Parks W C
The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix.
The Journal of cell biology 1997;137(6):1445-57.
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1996: Dunsmore S E; Rubin J S; Kovacs S O; Chedid M; Parks W C; Welgus H G
Mechanisms of hepatocyte growth factor stimulation of keratinocyte metalloproteinase production.
The Journal of biological chemistry 1996;271(40):24576-82.
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1996: Halpert I; Sires U I; Roby J D; Potter-Perigo S; Wight T N; Shapiro S D; Welgus H G; Wickline S A; Parks W C
Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9748-53.
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1996: Pierce R A; Sandefur S; Doyle G A; Welgus H G
Monocytic cell type-specific transcriptional induction of collagenase.
The Journal of clinical investigation 1996;97(8):1890-9.
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1996: Shipley J M; Doyle G A; Fliszar C J; Ye Q Z; Johnson L L; Shapiro S D; Welgus H G; Senior R M
The structural basis for the elastolytic activity of the 92-kDa and 72-kDa gelatinases. Role of the fibronectin type II-like repeats.
The Journal of biological chemistry 1996;271(8):4335-41.
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1995: Cornelius L A; Nehring L C; Roby J D; Parks W C; Welgus H G
Human dermal microvascular endothelial cells produce matrix metalloproteinases in response to angiogenic factors and migration.
The Journal of investigative dermatology 1995;105(2):170-6.
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1995: Busiek D F; Baragi V; Nehring L C; Parks W C; Welgus H G
Matrilysin expression by human mononuclear phagocytes and its regulation by cytokines and hormones.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(12):6484-91.
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1995: Sires U I; Schmid T M; Fliszar C J; Wang Z Q; Gluck S L; Welgus H G
Complete degradation of type X collagen requires the combined action of interstitial collagenase and osteoclast-derived cathepsin-B.
The Journal of clinical investigation 1995;95(5):2089-95.
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1995: Shapiro S D; Fliszar C J; Broekelmann T J; Mecham R P; Senior R M; Welgus H G
Activation of the 92-kDa gelatinase by stromelysin and 4-aminophenylmercuric acetate. Differential processing and stabilization of the carboxyl-terminal domain by tissue inhibitor of metalloproteinases (TIMP).
The Journal of biological chemistry 1995;270(11):6351-6.
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1995: Sires U I; Dublet B; Aubert-Foucher E; van der Rest M; Welgus H G
Degradation of the COL1 domain of type XIV collagen by 92-kDa gelatinase.
The Journal of biological chemistry 1995;270(3):1062-7.
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1995: Pentland A P; Shapiro S D; Welgus H G
Agonist-induced expression of tissue inhibitor of metalloproteinases and metalloproteinases by human macrophages is regulated by endogenous prostaglandin E2 synthesis.
The Journal of investigative dermatology 1995;104(1):52-7.
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1994: Sudbeck B D; Parks W C; Welgus H G; Pentland A P
Collagen-stimulated induction of keratinocyte collagenase is mediated via tyrosine kinase and protein kinase C activities.
The Journal of biological chemistry 1994;269(47):30022-9.
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1994: Sires U I; Murphy G; Baragi V M; Fliszar C J; Welgus H G; Senior R M
Matrilysin is much more efficient than other matrix metalloproteinases in the proteolytic inactivation of alpha 1-antitrypsin.
Biochemical and biophysical research communications 1994;204(2):613-20.
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1994: Saarialho-Kere U K; Pentland A P; Birkedal-Hansen H; Parks W C; Welgus H G
Distinct populations of basal keratinocytes express stromelysin-1 and stromelysin-2 in chronic wounds.
The Journal of clinical investigation 1994;94(1):79-88.
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1994: Baragi V M; Fliszar C J; Conroy M C; Ye Q Z; Shipley J M; Welgus H G
Contribution of the C-terminal domain of metalloproteinases to binding by tissue inhibitor of metalloproteinases. C-terminal truncated stromelysin and matrilysin exhibit equally compromised binding affinities as compared to full-length stromelysin.
The Journal of biological chemistry 1994;269(17):12692-7.
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1993: Saarialho-Kere U K; Kovacs S O; Pentland A P; Olerud J E; Welgus H G; Parks W C
Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing.
The Journal of clinical investigation 1993;92(6):2858-66.
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1993: Saarialho-Kere U K; Welgus H G; Parks W C
Distinct mechanisms regulate interstitial collagenase and 92-kDa gelatinase expression in human monocytic-like cells exposed to bacterial endotoxin.
The Journal of biological chemistry 1993;268(23):17354-61.
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1993: Shapiro S D; Kobayashi D K; Pentland A P; Welgus H G
Induction of macrophage metalloproteinases by extracellular matrix. Evidence for enzyme- and substrate-specific responses involving prostaglandin-dependent mechanisms.
The Journal of biological chemistry 1993;268(11):8170-5.
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1993: Saarialho-Kere U K; Chang E S; Welgus H G; Parks W C
Expression of interstitial collagenase, 92-kDa gelatinase, and tissue inhibitor of metalloproteinases-1 in granuloma annulare and necrobiosis lipoidica diabeticorum.
The Journal of investigative dermatology 1993;100(3):335-42.
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1993: Sires U I; Griffin G L; Broekelmann T J; Mecham R P; Murphy G; Chung A E; Welgus H G; Senior R M
Degradation of entactin by matrix metalloproteinases. Susceptibility to matrilysin and identification of cleavage sites.
The Journal of biological chemistry 1993;268(3):2069-74.
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1992: Saarialho-Kere U K; Chang E S; Welgus H G; Parks W C
Distinct localization of collagenase and tissue inhibitor of metalloproteinases expression in wound healing associated with ulcerative pyogenic granuloma.
The Journal of clinical investigation 1992;90(5):1952-7.
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1992: Ståhle-Bäckdahl M; Sudbeck B D; Eisen A Z; Welgus H G; Parks W C
Expression of 92-kDa type IV collagenase mRNA by eosinophils associated with basal cell carcinoma.
The Journal of investigative dermatology 1992;99(4):497-503.
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1992: Shapiro S D; Kobayashi D K; Welgus H G
Identification of TIMP-2 in human alveolar macrophages. Regulation of biosynthesis is opposite to that of metalloproteinases and TIMP-1.
The Journal of biological chemistry 1992;267(20):13890-4.
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1992: Shapiro S D; Griffin G L; Gilbert D J; Jenkins N A; Copeland N G; Welgus H G; Senior R M; Ley T J
Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase.
The Journal of biological chemistry 1992;267(7):4664-71.
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1992: Sudbeck B D; Jeffrey J J; Welgus H G; Mecham R P; McCourt D; Parks W C
Purification and characterization of bovine interstitial collagenase and tissue inhibitor of metalloproteinases.
Archives of biochemistry and biophysics 1992;293(2):370-6.
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1992: Welgus H G; Senior R M; Parks W C; Kahn A J; Ley T J; Shapiro S D; Campbell E J
Neutral proteinase expression by human mononuclear phagocytes: a prominent role of cellular differentiation.
Matrix (Stuttgart, Germany). Supplement 1992;1():363-7.
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1991: Senior R M; Griffin G L; Fliszar C J; Shapiro S D; Goldberg G I; Welgus H G
Human 92- and 72-kilodalton type IV collagenases are elastases.
The Journal of biological chemistry 1991;266(12):7870-5.
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1991: Shapiro S D; Campbell E J; Kobayashi D K; Welgus H G
Dexamethasone selectively modulates basal and lipopolysaccharide-induced metalloproteinase and tissue inhibitor of metalloproteinase production by human alveolar macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(8):2724-9.
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1991: Campbell E J; Cury J D; Shapiro S D; Goldberg G I; Welgus H G
Neutral proteinases of human mononuclear phagocytes. Cellular differentiation markedly alters cell phenotype for serine proteinases, metalloproteinases, and tissue inhibitor of metalloproteinases.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(4):1286-93.
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1991: Shapiro S D; Campbell E J; Welgus H G; Senior R M
Elastin degradation by mononuclear phagocytes.
Annals of the New York Academy of Sciences 1991;624():69-80.
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1991: Welgus H G
Stromelysin: structure and function.
Agents and actions. Supplements 1991;35():61-7.
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1990: Welgus H G; Campbell E J; Cury J D; Eisen A Z; Senior R M; Wilhelm S M; Goldberg G I
Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development.
The Journal of clinical investigation 1990;86(5):1496-502.
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1990: Shapiro S D; Campbell E J; Kobayashi D K; Welgus H G
Immune modulation of metalloproteinase production in human macrophages. Selective pretranslational suppression of interstitial collagenase and stromelysin biosynthesis by interferon-gamma.
The Journal of clinical investigation 1990;86(4):1204-10.
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1990: Welgus H G; Fliszar C J; Seltzer J L; Schmid T M; Jeffrey J J
Differential susceptibility of type X collagen to cleavage by two mammalian interstitial collagenases and 72-kDa type IV collagenase.
The Journal of biological chemistry 1990;265(23):13521-7.
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1989: Rifas L; Halstead L R; Peck W A; Avioli L V; Welgus H G
Human osteoblasts in vitro secrete tissue inhibitor of metalloproteinases and gelatinase but not interstitial collagenase as major cellular products.
The Journal of clinical investigation 1989;84(2):686-94.
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1989: Senior R M; Connolly N L; Cury J D; Welgus H G; Campbell E J
Elastin degradation by human alveolar macrophages. A prominent role of metalloproteinase activity.
The American review of respiratory disease 1989;139(5):1251-6.
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1988: Cury J D; Campbell E J; Lazarus C J; Albin R J; Welgus H G
Selective up-regulation of human alveolar macrophage collagenase production by lipopolysaccharide and comparison to collagenase production by fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(12):4306-12.
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1988: Roswit W T; Rifas L; Gast M J; Welgus H G; Jeffrey J J
Purification and characterization of human myometrial smooth muscle collagenase.
Archives of biochemistry and biophysics 1988;262(1):67-75.
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1988: Bauer E A; Pentland A P; Kronberger A; Wilhelm S M; Goldberg G I; Welgus H G; Eisen A Z
Keratinocyte- and tumor-derived inducers of collagenase.
Annals of the New York Academy of Sciences 1988;548():174-9.
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1987: Clark S D; Kobayashi D K; Welgus H G
Regulation of the expression of tissue inhibitor of metalloproteinases and collagenase by retinoids and glucocorticoids in human fibroblasts.
The Journal of clinical investigation 1987;80(5):1280-8.
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1987: Albin R J; Senior R M; Welgus H G; Connolly N L; Campbell E J
Human alveolar macrophages secrete an inhibitor of metalloproteinase elastase.
The American review of respiratory disease 1987;135(6):1281-5.
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1987: Partridge N C; Jeffrey J J; Ehlich L S; Teitelbaum S L; Fliszar C; Welgus H G; Kahn A J
Hormonal regulation of the production of collagenase and a collagenase inhibitor activity by rat osteogenic sarcoma cells.
Endocrinology 1987;120(5):1956-62.
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1986: Welgus H G; Connolly N L; Senior R M
12-o-Tetradecanoyl-phorbol-13-acetate-differentiated U937 cells express a macrophage-like profile of neutral proteinases. High levels of secreted collagenase and collagenase inhibitor accompany low levels of intracellular elastase and cathepsin G.
The Journal of clinical investigation 1986;77(5):1675-81.
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1985: Welgus H G; Grant G A; Sacchettini J C; Roswit W T; Jeffrey J J
The gelatinolytic activity of rat uterus collagenase.
The Journal of biological chemistry 1985;260(25):13601-6.
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1985: Clark S D; Wilhelm S M; Stricklin G P; Welgus H G
Coregulation of collagenase and collagenase inhibitor production by phorbol myristate acetate in human skin fibroblasts.
Archives of biochemistry and biophysics 1985;241(1):36-44.
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1985: Welgus H G; Jeffrey J J; Eisen A Z; Roswit W T; Stricklin G P
Human skin fibroblast collagenase: interaction with substrate and inhibitor.
Collagen and related research 1985;5(2):167-79.
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1985: Welgus H G; Burgeson R E; Wootton J A; Minor R R; Fliszar C; Jeffrey J J
Degradation of monomeric and fibrillar type III collagens by human skin collagenase. Kinetic constants using different animal substrates.
The Journal of biological chemistry 1985;260(2):1052-9.
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1980: Welgus H G; Jeffrey J J; Stricklin G P; Roswit W T; Eisen A Z
Characteristics of the action of human skin fibroblast collagenase on fibrillar collagen.
The Journal of biological chemistry 1980;255(14):6806-13.
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