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Thomas Wellems

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TOP 3
Louis H Miller; Xin-zhuan Su; Hans C Ackerman; Thomas E Wellems
Malaria biology and disease pathogenesis: insights for new treatments.
Karen Hayton; Bruce Henschen; Anna Liu; Janni Papakrivos; Peter Dumoulin; Thomas E Wellems
Various PfRH5 polymorphisms can support Plasmodium falciparum invasion into the erythrocytes of owl monkeys and rats.
Abdoulaye Kone; Hamma Maiga; Jianbing Mu; Issaka Sagara; Mamadou M Tekete; Aliou Traoré; Oumar B Traore; Thomas E Wellems; Omar Yattara; Abdoul H Beavogui; Anders Björkman; Souleymane Dama; Antoine Dara; Nouhoum Diallo; Ogobara K Doumbo; J Pedro Gil; Aly Kodio; Abdoulaye A Djimde
Quinine treatment selects the pfnhe-1 ms4760-1 polymorphism in Malian patients with Falciparum malaria.

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All Publications

2013: Louis H Miller; Xin-zhuan Su; Hans C Ackerman; Thomas E Wellems
Malaria biology and disease pathogenesis: insights for new treatments.
Nature medicine 2013;19(2):156-67.
2013: Karen Hayton; Bruce Henschen; Anna Liu; Janni Papakrivos; Peter Dumoulin; Thomas E Wellems
Various PfRH5 polymorphisms can support Plasmodium falciparum invasion into the erythrocytes of owl monkeys and rats.
Molecular and biochemical parasitology 2013;187(2):103-10.
2013: Abdoulaye Kone; Hamma Maiga; Jianbing Mu; Issaka Sagara; Mamadou M Tekete; Aliou Traoré; Oumar B Traore; Thomas E Wellems; Omar Yattara; Abdoul H Beavogui; Anders Björkman; Souleymane Dama; Antoine Dara; Nouhoum Diallo; Ogobara K Doumbo; J Pedro Gil; Aly Kodio; Abdoulaye A Djimde
Quinine treatment selects the pfnhe-1 ms4760-1 polymorphism in Malian patients with Falciparum malaria.
The Journal of infectious diseases 2013;207(3):520-7.
2012: Rick M Fairhurst; Rachel Hallett; Gaurvika M L Nayyar; Christopher Plowe; Pascal Ringwald; Jonathan L Vennerstrom; Thomas E Wellems; Joel G Breman; Socheat Duong; Arjen M Dondorp
Artemisinin-resistant malaria: research challenges, opportunities, and public health implications.
The American journal of tropical medicine and hygiene 2012;87(2):231-41.
2012: Thomas E Wellems; Rick M Fairhurst
An evolving picture of the interactions between malaria parasites and their host erythrocytes.
Cell research 2012;22(3):453-6.
2012: Janni Papakrivos; Juliana Martha Sá; Thomas E Wellems
Functional characterization of the Plasmodium falciparum chloroquine-resistance transporter (PfCRT) in transformed Dictyostelium discoideum vesicles.
PloS one 2012;7(6):e39569.
2012: Brian Lyko; Wang Nguitragool; Thomas E Wellems; Elizabeth A Hammershaimb; Sanjay A Desai
A high-throughput method to detect Plasmodium falciparum clones in limiting dilution microplates.
Malaria journal 2012;11():124.
2012: Shivang S Shah; Karim Traore; Thomas E Wellems; Mahamadou DIAKITE; Seidina A S Diakite; Dominic P Kwiatkowski; Kirk A Rockett; Rick M Fairhurst
A novel cytofluorometric assay for the detection and quantification of glucose-6-phosphate dehydrogenase deficiency.
Scientific reports 2012;2():299.
2012: Laura W Musselwhite; Gloria Tavera; Thomas E Wellems; Rebecca E Goulding; Michael C Gretes; Alex Lankowski; Karolina Maciag; Ethan Guillen
First Universities Allied for Essential Medicines (UAEM) Neglected Diseases and Innovation Symposium.
The American journal of tropical medicine and hygiene 2012;86(1):65-74.
2011: Arjen M Dondorp; Rick M Fairhurst; Philippe J Guerin; John R Macarthur; Robert D Newman; Pascal Ringwald; Laurence Slutsker; Thomas E Wellems; Joel G Breman; Christopher Plowe
The threat of artemisinin-resistant malaria.
The New England journal of medicine 2011;365(12):1073-5.
2011: Ando Guindo; Karim Traore; Thomas E Wellems; Seidina Diakite; Ogobara K Doumbo; Dapa A Diallo
An evaluation of concurrent G6PD (A-) deficiency and sickle cell trait in Malian populations of children with severe or uncomplicated P. falciparum malaria.
American journal of hematology 2011;86(9):795-6.
2011: Jing Yuan; Thomas E Wellems; Christopher P Austin; Ken Chih-Chien Cheng; Fidock David; Rajarshi Guha; Ruili Huang; James Inglese; Ronald L Johnson; Anna Liu; Sittiporn Pattaradilokrat; Xin-zhuan Su
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
Science (New York, N.Y.) 2011;333(6043):724-9.
2011: Mamadou Wélé; Abdoulaye A Djimdé; Ando Guindo; Abdoul H Beavogui; Isaac Z Traoré; Aboubacar Sadou; Dackouo Blaise; Dapa A Diallo; Thomas E Wellems; Ogobara K Doumbo
High frequency of PfCRT 76T in two Malian villages and its prevalence in severe relative to non-severe malaria.
Acta tropica 2011;119(1):11-3.
2011: Juliana Martha Sá; Jason L Chong; Thomas E Wellems
Malaria drug resistance: new observations and developments.
Essays in biochemistry 2011;51():137-60.
2011: Georgeta Crivat; Jeeseong Hwang; Juliana Martha Sa; Fuyuki Tokumasu; Thomas E Wellems
Tetracysteine-based fluorescent tags to study protein localization and trafficking in Plasmodium falciparum-infected erythrocytes.
PloS one 2011;6(8):e22975.
2011: Hongying Jiang; Jian Li; Na Li; Gil McVean; Jianbing Mu; Vijayaraj Nagarajan; Robert Stephens; Philip Awadalla; Vivek Gopalan; Karen Hayton; Bruce Henschen; Sudhir Varma; Thomas E Wellems; Ming Yi; Martine M Zilversmit; Xin-zhuan Su
High recombination rates and hotspots in a Plasmodium falciparum genetic cross.
Genome biology 2011;12(4):R33.
2010: Thomas E Wellems
Optimism, persistence, and our collective crystal ball.
The American journal of tropical medicine and hygiene 2010;83(1):1-6.
2010: Jianbing Mu; Rachel A Myers; Hongying Jiang; Shengfa Liu; Stacy Ricklefs; Michael Waisberg; Kesinee Chotivanich; Polrat Wilairatana; Srivicha Krudsood; Nicholas J White; Rachanee Udomsangpetch; Liwang Cui; May Ho; Fengzhen Ou; Haibo Li; Jianping Song; Guoqiao Li; Xinhua Wang; Suon Seila; Sreng Sokunthea; Duong Socheat; Daniel E Sturdevant; Stephen F Porcella; Rick M Fairhurst; Thomas E Wellems; Philip Awadalla; Xin-zhuan Su
Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs.
Nature genetics 2010;42(3):268-71.
2009: Juliana Martha Sá; Olivia Twu; Karen Hayton; Sahily Reyes; Michael P Fay; Pascal Ringwald; Thomas E Wellems
Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(45):18883-9.
2009: Jing Yuan; Ronald L Johnson; Ruili Huang; Jennifer Wichterman; Hongying Jiang; Karen Hayton; Fidock David; Thomas E Wellems; James Inglese; Christopher P Austin; Xin-zhuan Su
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nature chemical biology 2009;5(10):765-71.
2009: Thomas E Wellems; Karen Hayton; Rick M Fairhurst
The impact of malaria parasitism: from corpuscles to communities.
The Journal of clinical investigation 2009;119(9):2496-505.
2009: Louis J Nkrumah; Paul M Riegelhaupt; Pedro Moura; David J Johnson; Jigar Patel; Karen Hayton; Michael T Ferdig; Thomas E Wellems; Myles H Akabas; Fidock David
Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE.
Molecular and biochemical parasitology 2009;165(2):122-31.
2008: Karen Hayton; Deepak Gaur; Anna Liu; Jonathan Takahashi; Bruce Henschen; Subhash Singh; Lynn Lambert; Tetsuya Furuya; Rachel Bouttenot; Michelle Doll; Fatima Nawaz; Jianbing Mu; Lubin Jiang; Louis H Miller; Thomas E Wellems
Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion.
Cell host & microbe 2008;4(1):40-51.
2008: Rushina Cholera; Nathaniel J Brittain; Mark R Gillrie; Tatiana M Lopera-Mesa; Séidina A S Diakité; Takayuki Arie; Michael A Krause; Ando Guindo; Abby Tubman; Hisashi Fujioka; Dapa A Diallo; Ogobara K Doumbo; May Ho; Thomas E Wellems; Rick M Fairhurst
Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(3):991-6.
2007: Ron Dzikowski; Felomena Li; Borko Amulic; Andrew Eisberg; Matthias Frank; Suchit Patel; Thomas E Wellems; Kirk W Deitsch
Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasites.
EMBO reports 2007;8(10):959-65.
2007: Xinzhuan Su; Karen Hayton; Thomas E Wellems
Genetic linkage and association analyses for trait mapping in Plasmodium falciparum.
Nature reviews. Genetics 2007;8(7):497-506.
2007: Ando Guindo; Rick M Fairhurst; Ogobara K Doumbo; Thomas E Wellems; Dapa A Diallo
X-linked G6PD deficiency protects hemizygous males but not heterozygous females against severe malaria.
PLoS medicine 2007;4(3):e66.
2007: Abdoulaye A Djimde; L Kirkman; L Kassambara; M Diallo; Christopher Plowe; Thomas E Wellems; Ogobara K Doumbo
[In vitro cultivation of fields isolates of Plasmodium falciparum in Mali].
Bulletin de la Société de pathologie exotique (1990) 2007;100(1):3-5.
2007: Nathaniel J Brittain; Cindy Erexson; Lawrence Faucette; Jerrold Ward; Hisashi Fujioka; Thomas E Wellems; Rick M Fairhurst
Non-opsonising aggregates of IgG and complement in haemoglobin C erythrocytes.
British journal of haematology 2007;136(3):491-500.
2007: Roland A Cooper; Kristin D Lane; Bingbing Deng; Jianbing Mu; Jigar J Patel; Thomas E Wellems; Xinzhuan Su; Michael T Ferdig
Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine.
Molecular microbiology 2007;63(1):270-82.
2006: Juliana Martha Sá; Marcio M Yamamoto; Carmen Fernandez-Becerra; Mauro Ferreira de Azevedo; Janni Papakrivos; Bronwen Naudé; Thomas E Wellems; Hernando A del Portillo
Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt, in Plasmodium falciparum and Dictyostelium discoideum.
Molecular and biochemical parasitology 2006;150(2):219-28.
2006: Rick M Fairhurst; Thomas E Wellems
Modulation of malaria virulence by determinants of Plasmodium falciparum erythrocyte membrane protein-1 display.
Current opinion in hematology 2006;13(3):124-30.
2005: Roland A Cooper; Janni Papakrivos; Kristin D Lane; Hisashi Fujioka; Klaus Lingelbach; Thomas E Wellems
PfCG2, a Plasmodium falciparum protein peripherally associated with the parasitophorous vacuolar membrane, is expressed in the period of maximum hemoglobin uptake and digestion by trophozoites.
Molecular and biochemical parasitology 2005;144(2):167-76.
2005: Tetsuya Furuya; Jianbing Mu; Karen Hayton; Anna Liu; Junhui Duan; Louis Nkrumah; Deirdre Joy; Fidock David; Hisashi Fujioka; Akhil B Vaidya; Thomas E Wellems; Xin-zhuan Su
Disruption of a Plasmodium falciparum gene linked to male sexual development causes early arrest in gametocytogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(46):16813-8.
2005: Thomas E Wellems; Rick M Fairhurst
Malaria-protective traits at odds in Africa?
Nature genetics 2005;37(11):1160-2.
2005: Dapa A Diallo; Ogobara K Doumbo; Christopher Plowe; Thomas E Wellems; Ezekiel J Emanuel; Samia Hurst
Community permission for medical research in developing countries.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;41(2):255-9.
2005: Bronwen Naudé; Joseph A Brzostowski; Alan R Kimmel; Thomas E Wellems
Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT.
The Journal of biological chemistry 2005;280(27):25596-603.
2005: Rick M Fairhurst; Dror I Baruch; Nathaniel J Brittain; Graciela R Ostera; John S Wallach; Holly L Hoang; Karen Hayton; Ando Guindo; Morris O Makobongo; Owen M Schwartz; Anatole Tounkara; Ogobara K Doumbo; Dapa A Diallo; Hisashi Fujioka; May Ho; Thomas E Wellems
Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria.
Nature 2005;435(7045):1117-21.
2005: Takayuki Arie; Rick M Fairhurst; Nathaniel J Brittain; Thomas E Wellems; James A Dvorak
Hemoglobin C modulates the surface topography of Plasmodium falciparum-infected erythrocytes.
Journal of structural biology 2005;150(2):163-9.
2005: Xinhua Wang; Jianbing Mu; Guoqiao Li; Peiquan Chen; Xingbo Guo; Linchun Fu; Lin Chen; Xinzhuan Su; Thomas E Wellems
Decreased prevalence of the Plasmodium falciparum chloroquine resistance transporter 76T marker associated with cessation of chloroquine use against P. falciparum malaria in Hainan, People's Republic of China.
The American journal of tropical medicine and hygiene 2005;72(4):410-4.
2005: Juliana Martha Sá; Takashi Nomura; Joana d'Arc Neves; J Kevin Baird; Thomas E Wellems; Hernando A del Portillo
Plasmodium vivax: allele variants of the mdr1 gene do not associate with chloroquine resistance among isolates from Brazil, Papua, and monkey-adapted strains.
Experimental parasitology 2005;109(4):256-9.
2005: Fuyuki Tokumasu; Rick M Fairhurst; Graciela R Ostera; Nathaniel J Brittain; Jeeseong Hwang; Thomas E Wellems; James A Dvorak
Band 3 modifications in Plasmodium falciparum-infected AA and CC erythrocytes assayed by autocorrelation analysis using quantum dots.
Journal of cell science 2005;118(Pt 5):1091-8.
2005: Laïla Gannoun-Zaki; Amy Jost; Jianbing Mu; Kirk W Deitsch; Thomas E Wellems
A silenced Plasmodium falciparum var promoter can be activated in vivo through spontaneous deletion of a silencing element in the intron.
Eukaryotic cell 2005;4(2):490-2.
2004: Thomas E Wellems
Transporter of a malaria catastrophe.
Nature medicine 2004;10(11):1169-71.
2004: Michael T Ferdig; Roland A Cooper; Jianbing Mu; Bingbing Deng; Deirdre Joy; Xin-zhuan Su; Thomas E Wellems
Dissecting the loci of low-level quinine resistance in malaria parasites.
Molecular microbiology 2004;52(4):985-97.
2004: Dapa A Diallo; Ogobara K Doumbo; Alassane Dicko; Ando Guindo; Drissa Coulibaly; Kassoum Kayentao; Abdoulaye A Djimdé; Mahamadou A Théra; Rick M Fairhurst; Christopher Plowe; Thomas E Wellems
A comparison of anemia in hemoglobin C and normal hemoglobin A children with Plasmodium falciparum malaria.
Acta tropica 2004;90(3):295-9.
2003: L Aravind; Lakshminarayan M Iyer; Thomas E Wellems; Louis H Miller
Plasmodium biology: genomic gleanings.
Cell 2003;115(7):771-85.
2003: Abdoulaye A Djimdé; Ogobara K Doumbo; Ousmane Traore; Ando Guindo; Kassoum Kayentao; Yacouba Diourte; Safiatou Niare-Doumbo; Drissa Coulibaly; Abdoulaye Kone; Yacouba Cissoko; Mamadou Tekete; Bakary Fofana; Alassane Dicko; Dapa A Diallo; Thomas E Wellems; Dominic Kwiatkowski; Christopher Plowe
Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria.
The American journal of tropical medicine and hygiene 2003;69(5):558-63.
2003: Thomas E Wellems; Louis H Miller
Two worlds of malaria.
The New England journal of medicine 2003;349(16):1496-8.
2003: Michael S Calderwood; Laila Gannoun-Zaki; Thomas E Wellems; Kirk W Deitsch
Plasmodium falciparum var genes are regulated by two regions with separate promoters, one upstream of the coding region and a second within the intron.
The Journal of biological chemistry 2003;278(36):34125-32.
2003: Rick M Fairhurst; B Sadou; Ando Guindo; Dapa A Diallo; Ogobara K Doumbo; Thomas E Wellems
Case report: life-threatening hypoglycaemia associated with sulfadoxine-pyrimethamine, a commonly used antimalarial drug.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2003;97(5):595-6.
2003: Rick M Fairhurst; Hisashi Fujioka; Karen Hayton; Kathleen F Collins; Thomas E Wellems
Aberrant development of Plasmodium falciparum in hemoglobin CC red cells: implications for the malaria protective effect of the homozygous state.
Blood 2003;101(8):3309-15.
2002: Thomas E Wellems
Plasmodium chloroquine resistance and the search for a replacement antimalarial drug.
Science (New York, N.Y.) 2002;298(5591):124-6.
2002: Andrew G Evans; Thomas E Wellems
Coevolutionary genetics of Plasmodium malaria parasites and their human hosts.
Integrative and comparative biology 2002;42(2):401-7.
2002: Roland A Cooper; Michael T Ferdig; Xin-zhuan Su; Lyann M B Ursos; Jianbing Mu; Takashi Nomura; Hisashi Fujioka; Fidock David; Paul D Roepe; Thomas E Wellems
Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum.
Molecular pharmacology 2002;61(1):35-42.
2001: Thomas E Wellems; Christopher Plowe
Chloroquine-resistant malaria.
The Journal of infectious diseases 2001;184(6):770-6.
2001: Kirk W Deitsch; M S Calderwood; Thomas E Wellems
Malaria. Cooperative silencing elements in var genes.
Nature 2001;412(6850):875-6.
2001: Jane Carlton; Fidock David; Abdoulaye A Djimdé; Christopher Plowe; Thomas E Wellems
Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of P. falciparum.
Current opinion in microbiology 2001;4(4):415-20.
2001: Takashi Nomura; J M Carlton; J Kevin Baird; Hernando A del Portillo; David J Fryauff; Dharmendar Rathore; Fidock David; X Su; W E Collins; Thomas F McCutchan; John C Wootton; Thomas E Wellems
Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria.
The Journal of infectious diseases 2001;183(11):1653-61.
2001: Christopher Plowe; Ogobara K Doumbo; Abdoulaye A Djimde; Kassoum Kayentao; Yacouba Diourte; S N Doumbo; Drissa Coulibaly; Mahamadou A Thera; Thomas E Wellems; Dapa A Diallo
Chloroquine treatment of uncomplicated Plasmodium falciparum malaria in Mali: parasitologic resistance versus therapeutic efficacy.
The American journal of tropical medicine and hygiene 2001;64(5-6):242-6.
2001: Kirk W Deitsch; J M Carlton; John C Wootton; Thomas E Wellems
Host sequences in Plasmodium falciparum and Plasmodium vivax genomic DNA: horizontal transfer or contamination artifact?
FEBS letters 2001;491(1-2):164-5.
2001: Madhusudan Kadekoppala; Paul Cheresh; Drew M Catron; D D Ji; Kirk W Deitsch; Thomas E Wellems; H S Seifert; Kasturi Haldar
Rapid recombination among transfected plasmids, chimeric episome formation and trans gene expression in Plasmodium falciparum.
Molecular and biochemical parasitology 2001;112(2):211-8.
2001: Kirk W Deitsch; C Driskill; Thomas E Wellems
Transformation of malaria parasites by the spontaneous uptake and expression of DNA from human erythrocytes.
Nucleic acids research 2001;29(3):850-3.
2001: Abdoulaye A Djimdé; Ogobara K Doumbo; Joseph F Cortese; Kassoum Kayentao; S Doumbo; Y Diourté; Alassane Dicko; Xin-zhuan Su; T Nomura; Fidock David; Thomas E Wellems; D Coulibaly; Christopher Plowe
A molecular marker for chloroquine-resistant falciparum malaria.
The New England journal of medicine 2001;344(4):257-63.
2000: Lucio Freitas-Junior; Emmanuel Bottius; Lindsay A Pirrit; Kirk W Deitsch; Christine Scheidig; F Guinet; U Nehrbass; Thomas E Wellems; Artur Scherf
Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum.
Nature 2000;407(6807):1018-22.
2000: Fidock David; Takashi Nomura; A K Talley; Roland A Cooper; Sergey Dzekunov; Michael T Ferdig; Lyann M B Ursos; Amar Bir Singh Sidhu; Bronwen Naudé; Kirk W Deitsch; Xin-zhuan Su; John C Wootton; Paul D Roepe; Thomas E Wellems
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.
Molecular cell 2000;6(4):861-71.
2000: A Agarwal; Ando Guindo; Yacouba Cissoko; James G Taylor; Drissa Coulibaly; Abdoulaye K Koné; Kassoum Kayentao; Abdoulaye A Djimde; Christopher Plowe; Ogobara K Doumbo; Thomas E Wellems; Dapa A Diallo
Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S.
Blood 2000;96(7):2358-63.
2000: Fidock David; Takashi Nomura; Roland A Cooper; X Su; A K Talley; Thomas E Wellems
Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum.
Molecular and biochemical parasitology 2000;110(1):1-10.
2000: J G Taylor; Michael T Ferdig; Xin-zhuan Su; Thomas E Wellems
Toward quantitative genetic analysis of host and parasite traits in the manifestations of Plasmodium falciparum malaria.
Current opinion in genetics & development 2000;10(3):314-9.
2000: David S Peterson; Thomas E Wellems
EBL-1, a putative erythrocyte binding protein of Plasmodium falciparum, maps within a favored linkage group in two genetic crosses.
Molecular and biochemical parasitology 2000;105(1):105-13.
1999: X Su; Michael T Ferdig; Y Huang; C Q Huynh; A Liu; J You; John C Wootton; Thomas E Wellems
A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum.
Science (New York, N.Y.) 1999;286(5443):1351-3.
1999: Thomas E Wellems; Xin-zhuan Su; Michael T Ferdig; Fidock David
Genome projects, genetic analysis, and the changing landscape of malaria research.
Current opinion in microbiology 1999;2(4):415-9.
1999: Kirk W Deitsch; A del Pinal; Thomas E Wellems
Intra-cluster recombination and var transcription switches in the antigenic variation of Plasmodium falciparum.
Molecular and biochemical parasitology 1999;101(1-2):107-16.
1999: Xin-zhuan Su; Thomas E Wellems
Plasmodium falciparum: assignment of microsatellite markers to chromosomes by PFG-PCR.
Experimental parasitology 1999;91(4):367-9.
1998: Fidock David; T Nomura; Thomas E Wellems
Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase.
Molecular pharmacology 1998;54(6):1140-7.
1998: Abdoulaye A Djimde; Christopher Plowe; S Diop; Alassane Dicko; Thomas E Wellems; Ogobara K Doumbo
Use of antimalarial drugs in Mali: policy versus reality.
The American journal of tropical medicine and hygiene 1998;59(3):376-9.
1998: Thomas E Wellems; John C Wootton; Hisashi Fujioka; X Su; R Cooper; Dror I Baruch; Fidock David
P. falciparum CG2, linked to chloroquine resistance, does not resemble Na+/H+ exchangers.
Cell 1998;94(3):285-6.
1998: Xin-zhuan Su; D J Carucci; Thomas E Wellems
Plasmodium falciparum: parasite typing by using a multicopy microsatellite marker, PfRRM.
Experimental parasitology 1998;89(2):262-5.
1997: F Guinet; Thomas E Wellems
Physical mapping of a defect in Plasmodium falciparum male gametocytogenesis to an 800 kb segment of chromosome 12.
Molecular and biochemical parasitology 1997;90(1):343-6.
1997: X Su; L A Kirkman; Hisashi Fujioka; Thomas E Wellems
Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa.
Cell 1997;91(5):593-603.
1997: F Guinet; Dapa A Diallo; Daouda K Minta; Alassane Dicko; Mady Sissoko; Marouf M Keita; Thomas E Wellems; Ogobara K Doumbo
A comparison of the incidence of severe malaria in Malian children with normal and C-trait hemoglobin profiles.
Acta tropica 1997;68(2):175-82.
1997: Fidock David; Thomas E Wellems
Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):10931-6.
1997: Kirk W Deitsch; E R Moxon; Thomas E Wellems
Shared themes of antigenic variation and virulence in bacterial, protozoal, and fungal infections.
Microbiology and molecular biology reviews : MMBR 1997;61(3):281-93.
1997: B Khan; S Omar; J N Kanyara; M Warren-Perry; Julius Nyalwidhe; D S Peterson; Thomas E Wellems; S Kaniaru; J Gitonga; F J Mulaa; Davy K Koech
Antifolate drug resistance and point mutations in Plasmodium falciparum in Kenya.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1997;91(4):456-60.
1997: Xin-zhuan Su; Thomas E Wellems
Plasmodium falciparum: a rapid DNA fingerprinting method using microsatellite sequences within var clusters.
Experimental parasitology 1997;86(3):235-6.
1997: SC Soubes; Thomas E Wellems; Louis H Miller
Plasmodium falciparum: a high proportion of parasites from a population of the Dd2 strain are able to invade erythrocytes by an alternative pathway.
Experimental parasitology 1997;86(1):79-83.
1997: Daniel E Goldberg; Vijay Sharma; Anna Oksman; Ilya Y Gluzman; Thomas E Wellems; David Piwnica-Worms
Probing the chloroquine resistance locus of Plasmodium falciparum with a novel class of multidentate metal(III) coordination complexes.
The Journal of biological chemistry 1997;272(10):6567-72.
1997: Rosaura Hernandez-Rivas; Denise Mattei; Yvon Sterkers; David S Peterson; Thomas E Wellems; Artur Scherf
Expressed var genes are found in Plasmodium falciparum subtelomeric regions.
Molecular and cellular biology 1997;17(2):604-11.
1996: Christopher Plowe; Abdoulaye A Djimde; Thomas E Wellems; S Diop; B Kouriba; Ogobara K Doumbo
Community pyrimethamine-sulfadoxine use and prevalence of resistant Plasmodium falciparum genotypes in Mali: a model for deterring resistance.
The American journal of tropical medicine and hygiene 1996;55(5):467-71.
1996: F Guinet; J A Dvorak; H Fujioka; D B Keister; Olga Muratova; David C Kaslow; M Aikawa; A B Vaidya; Thomas E Wellems
A developmental defect in Plasmodium falciparum male gametogenesis.
The Journal of cell biology 1996;135(1):269-78.
1996: L A Kirkman; Xin-zhuan Su; Thomas E Wellems
Plasmodium falciparum: isolation of large numbers of parasite clones from infected blood samples.
Experimental parasitology 1996;83(1):147-9.
1996: X z Su; Thomas E Wellems
Toward a high-resolution Plasmodium falciparum linkage map: polymorphic markers from hundreds of simple sequence repeats.
Genomics 1996;33(3):430-44.
1996: Xin-zhuan Su; Y Wu; Costi D Sifri; Thomas E Wellems
Reduced extension temperatures required for PCR amplification of extremely A+T-rich DNA.
Nucleic acids research 1996;24(8):1574-5.
1996: Y Wu; L A Kirkman; Thomas E Wellems
Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):1130-4.
1996: Kirk W Deitsch; Thomas E Wellems
Membrane modifications in erythrocytes parasitized by Plasmodium falciparum.
Molecular and biochemical parasitology 1996;76(1-2):1-10.
1995: D S Peterson; Louis H Miller; Thomas E Wellems
Isolation of multiple sequences from the Plasmodium falciparum genome that encode conserved domains homologous to those in erythrocyte-binding proteins.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):7100-4.
1995: Xin-zhuan Su; V M Heatwole; S P Wertheimer; F Guinet; J A Herrfeldt; D S Peterson; J A Ravetch; Thomas E Wellems
The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes.
Cell 1995;82(1):89-100.
1995: Christopher Plowe; Abdoulaye A Djimde; M Bouare; Ogobara K Doumbo; Thomas E Wellems
Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa.
The American journal of tropical medicine and hygiene 1995;52(6):565-8.
1995: Y Wu; Costi D Sifri; H H Lei; Xin-zhuan Su; Thomas E Wellems
Transfection of Plasmodium falciparum within human red blood cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(4):973-7.
1995: Christopher Plowe; Thomas E Wellems
Molecular approaches to the spreading problem of drug resistant malaria.
Advances in experimental medicine and biology 1995;390():197-209.
1995: A B Vaidya; Olga Muratova; F Guinet; D Keister; Thomas E Wellems; David C Kaslow
A genetic locus on Plasmodium falciparum chromosome 12 linked to a defect in mosquito-infectivity and male gametogenesis.
Molecular and biochemical parasitology 1995;69(1):65-71.
1994: Xin-zhuan Su; Thomas E Wellems
Sequence, transcript characterization and polymorphisms of a Plasmodium falciparum gene belonging to the heat-shock protein (HSP) 90 family.
Gene 1994;151(1-2):225-30.
1994: K Hinterberg; Denise Mattei; Thomas E Wellems; Artur Scherf
Interchromosomal exchange of a large subtelomeric segment in a Plasmodium falciparum cross.
The EMBO journal 1994;13(17):4174-80.
1994: K A Creedon; Pradipsinh Rathod; Thomas E Wellems
Plasmodium falciparum S-adenosylhomocysteine hydrolase. cDNA identification, predicted protein sequence, and expression in Escherichia coli.
The Journal of biological chemistry 1994;269(23):16364-70.
1994: Stephen A Dolan; J L Proctor; D W Alling; Y Okubo; Thomas E Wellems; Louis H Miller
Glycophorin B as an EBA-175 independent Plasmodium falciparum receptor of human erythrocytes.
Molecular and biochemical parasitology 1994;64(1):55-63.
1993: Akhil B Vaidya; J Morrisey; Christopher Plowe; D C Kaslow; Thomas E Wellems
Unidirectional dominance of cytoplasmic inheritance in two genetic crosses of Plasmodium falciparum.
Molecular and cellular biology 1993;13(12):7349-57.
1993: Stephen A Dolan; J A Herrfeldt; Thomas E Wellems
Restriction polymorphisms and fingerprint patterns from an interspersed repetitive element of Plasmodium falciparum DNA.
Molecular and biochemical parasitology 1993;61(1):137-42.
1993: R Petter; S Rozenblatt; D Schechtman; Thomas E Wellems; David Mirelman
Electrophoretic karyotype and chromosome assignments for a pathogenic and a nonpathogenic strain of Entamoeba histolytica.
Infection and immunity 1993;61(8):3574-7.
1993: Stephen A Dolan; Rodney D Adam; Thomas E Wellems
Chromosome mapping methods for parasitic protozoa.
Methods in molecular biology (Clifton, N.J.) 1993;21():319-32.
1992: K A Creedon; David C Kaslow; Pradipsinh Rathod; Thomas E Wellems
Identification of a Plasmodium falciparum histone 2A gene.
Molecular and biochemical parasitology 1992;54(1):113-5.
1992: Tony Triglia; Thomas E Wellems; D J Kemp
Towards a high-resolution map of the Plasmodium falciparum genome.
Parasitology today (Personal ed.) 1992;8(7):225-9.
1992: O M Smith; Stephen A Dolan; J A Dvorak; Thomas E Wellems; Fritz Sieber
Merocyanine 540-sensitized photoinactivation of human erythrocytes parasitized by Plasmodium falciparum.
Blood 1992;80(1):21-4.
1992: F N Gyang; D S Peterson; Thomas E Wellems
Plasmodium falciparum: rapid detection of dihydrofolate reductase mutations that confer resistance to cycloguanil and pyrimethamine.
Experimental parasitology 1992;74(4):470-2.
1992: A Walker-Jonah; Stephen A Dolan; R W Gwadz; L J Panton; Thomas E Wellems
An RFLP map of the Plasmodium falciparum genome, recombination rates and favored linkage groups in a genetic cross.
Molecular and biochemical parasitology 1992;51(2):313-20.
1992: Thomas E Wellems
Malaria. How chloroquine works.
Nature 1992;355(6356):108-9.
1992: D J Krogstad; Ilya Y Gluzman; B L Herwaldt; P H Schlesinger; Thomas E Wellems
Energy dependence of chloroquine accumulation and chloroquine efflux in Plasmodium falciparum.
Biochemical pharmacology 1992;43(1):57-62.
1991: D S Peterson; S M Di Santi; M Povoa; V S Calvosa; V E Do Rosario; Thomas E Wellems
Prevalence of the dihydrofolate reductase Asn-108 mutation as the basis for pyrimethamine-resistant falciparum malaria in the Brazilian Amazon.
The American journal of tropical medicine and hygiene 1991;45(4):492-7.
1991: Rodney D Adam; Theodore E Nash; Thomas E Wellems
Telomeric location of Giardia rDNA genes.
Molecular and cellular biology 1991;11(6):3326-30.
1991: Thomas E Wellems
Molecular genetics of drug resistance in Plasmodium falciparum malaria.
Parasitology today (Personal ed.) 1991;7(5):110-2.
1991: Thomas E Wellems; A Walker-Jonah; L J Panton
Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3382-6.
1991: Stephen A Dolan; Louis H Miller; Thomas E Wellems
Selection of genetic variants from Plasmodium clones.
Acta Leidensia 1991;60(1):93-9.
1990: Kathryn J H Robson; J R Hall; Ceri Davies; Andrea Crisanti; A V Hill; Thomas E Wellems
Polymorphism of the TRAP gene of Plasmodium falciparum.
Proceedings. Biological sciences / The Royal Society 1990;242(1305):205-16.
1990: J H Adams; D E Hudson; M Torii; G E Ward; Thomas E Wellems; M Aikawa; Louis H Miller
The Duffy receptor family of Plasmodium knowlesi is located within the micronemes of invasive malaria merozoites.
Cell 1990;63(1):141-53.
1990: C Graziosi; R K Sakai; P Romans; Louis H Miller; Thomas E Wellems
Method for in situ hybridization to polytene chromosomes from ovarian nurse cells of Anopheles gambiae (Diptera: Culicidae).
Journal of medical entomology 1990;27(5):905-12.
1990: Stephen A Dolan; Louis H Miller; Thomas E Wellems
Evidence for a switching mechanism in the invasion of erythrocytes by Plasmodium falciparum.
The Journal of clinical investigation 1990;86(2):618-24.
1990: Ilya Y Gluzman; D J Krogstad; A U Orjih; K Nkangineme; Thomas E Wellems; J T Martin; P H Schlesinger
A rapid in vitro test for chloroquine-resistant Plasmodium falciparum.
The American journal of tropical medicine and hygiene 1990;42(6):521-6.
1990: Thomas E Wellems; L J Panton; Ilya Y Gluzman; V E do Rosario; R W Gwadz; A Walker-Jonah; D J Krogstad
Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross.
Nature 1990;345(6272):253-5.
1990: D S Peterson; W K Milhous; Thomas E Wellems
Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):3018-22.
1989: L J Panton; P McPhie; W L Maloy; Thomas E Wellems; D W Taylor; R J Howard
Purification and partial characterization of an unusual protein of Plasmodium falciparum: histidine-rich protein II.
Molecular and biochemical parasitology 1989;35(2):149-60.
1988: D S Peterson; D Walliker; Thomas E Wellems
Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):9114-8.
1988: Photini Sinnis; Thomas E Wellems
Long-range restriction maps of Plasmodium falciparum chromosomes: crossingover and size variation among geographically distant isolates.
Genomics 1988;3(4):287-95.
1988: D E Hudson; Thomas E Wellems; Louis H Miller
Molecular basis for mutation in a surface protein expressed by malaria parasites.
Journal of molecular biology 1988;203(3):707-14.
1988: Rodney D Adam; Theodore E Nash; Thomas E Wellems
The Giardia lamblia trophozoite contains sets of closely related chromosomes.
Nucleic acids research 1988;16(10):4555-67.
1988: Y C Yang; S Kovacic; Ron Kriz; Stanley Wolf; S C Clark; Thomas E Wellems; A Nienhuis; N Epstein
The human genes for GM-CSF and IL 3 are closely linked in tandem on chromosome 5.
Blood 1988;71(4):958-61.
1988: T F McCutchan; Vidal de la Cruz; M F Good; Thomas E Wellems
Antigenic diversity in Plasmodium falciparum.
Progress in allergy 1988;41():173-92.
1987: J Ellis; D O Irving; Thomas E Wellems; R J Howard; George A M Cross
Structure and expression of the knob-associated histidine-rich protein of Plasmodium falciparum.
Molecular and biochemical parasitology 1987;26(1-2):203-14.
1987: E P Rock; K Marsh; A J Saul; Thomas E Wellems; D W Taylor; W L Maloy; R J Howard
Comparative analysis of the Plasmodium falciparum histidine-rich proteins HRP-I, HRP-II and HRP-III in malaria parasites of diverse origin.
Parasitology 1987;95 ( Pt 2)():209-27.
1987: D Walliker; I A Quakyi; Thomas E Wellems; Thomas F McCutchan; A Szarfman; W T London; L M Corcoran; T R Burkot; R Carter
Genetic analysis of the human malaria parasite Plasmodium falciparum.
Science (New York, N.Y.) 1987;236(4809):1661-6.
1987: Thomas E Wellems; D Walliker; C L Smith; V E do Rosario; W L Maloy; R J Howard; R Carter; T F McCutchan
A histidine-rich protein gene marks a linkage group favored strongly in a genetic cross of Plasmodium falciparum.
Cell 1987;49(5):633-42.
1986: R J Howard; S Uni; M Aikawa; S B Aley; J H Leech; A M Lew; Thomas E Wellems; J Rener; D W Taylor
Secretion of a malarial histidine-rich protein (Pf HRP II) from Plasmodium falciparum-infected erythrocytes.
The Journal of cell biology 1986;103(4):1269-77.
1986: Thomas E Wellems; R J Howard
Homologous genes encode two distinct histidine-rich proteins in a cloned isolate of Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(16):6065-9.
1984: M J Potel; Thomas E Wellems; Robert Vassar; B Deer; R Josephs
Macrofiber structure and the dynamics of sickle cell hemoglobin crystallization.
Journal of molecular biology 1984;177(4):819-39.
1981: Thomas E Wellems; Robert Vassar; R Josephs
Polymorphic assemblies of double strands of sickle cell hemoglobin. Manifold pathways of deoxyhemoglobin S crystallization.
Journal of molecular biology 1981;153(4):1011-26.
1981: J Orr; L M Keefer; P Keim; T D Nguyen; Thomas E Wellems; R L Heinrikson; R Haselkorn
Purification, physical characterization, and NH2-terminal sequence of glutamine synthetase from the cyanobacterium Anabaena 7120.
The Journal of biological chemistry 1981;256(24):13091-8.
1980: Thomas E Wellems; R Josephs
Helical crystals of sickle cell hemoglobin.
Journal of molecular biology 1980;137(4):443-50.
1979: Thomas E Wellems; R Josephs
Crystallization of deoxyhemoglobin S by fiber alignment and fusion.
Journal of molecular biology 1979;135(3):651-74.
1977: M Ohtsuki; S L White; E Zeitler; Thomas E Wellems; S D Fuller; M Zwick; M W Makinen; P B Sigler
Electron microscopy of fibers and discs of hemoglobin S having sixfold symmetry.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(12):5538-42.