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Alan Wells

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Hanshuang Shao; Timothy Travers; Carlos J Camacho; Alan Wells
The carboxyl tail of alpha-actinin-4 regulates its susceptibility to m-calpain and thus functions in cell migration and spreading.
Alan Wells; Sarah Wheeler; Jelena Grahovac; Bo Ma; Douglas Lauffenburger
Targeting tumor cell motility as a strategy against invasion and metastasis.
Donald P Taylor; Chakra Chennubhotla; Andrej Savol; Jakob Z Wells; Alan Wells
Modeling boundary conditions for balanced proliferation in metastatic latency.

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All Publications

2013: Hanshuang Shao; Timothy Travers; Carlos J Camacho; Alan Wells
The carboxyl tail of alpha-actinin-4 regulates its susceptibility to m-calpain and thus functions in cell migration and spreading.
The international journal of biochemistry & cell biology 2013;45(6):1051-63.
2013: Alan Wells; Sarah Wheeler; Jelena Grahovac; Bo Ma; Douglas Lauffenburger
Targeting tumor cell motility as a strategy against invasion and metastasis.
Trends in pharmacological sciences 2013;34(5):283-9.
2013: Donald P Taylor; Chakra Chennubhotla; Andrej Savol; Jakob Z Wells; Alan Wells
Modeling boundary conditions for balanced proliferation in metastatic latency.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(5):1063-70.
2013: Timothy Travers; Alan Wells; Hanshuang Shao; Carlos J Camacho
Modeling the assembly of the multiple domains of α-actinin-4 and its role in actin cross-linking.
Biophysical journal 2013;104(3):705-15.
2013: Jelena Grahovac; Dorothea Becker; Alan Wells
Melanoma cell invasiveness is promoted at least in part by the epidermal growth factor-like repeats of tenascin-C.
The Journal of investigative dermatology 2013;133(1):210-20.
2012: Alan Wells; Zoltán N Oltvai
Ongoing technological revolution. Preface.
Clinics in laboratory medicine 2012;32(4):ix-x.
2012: Seung Park; Anil Vasdev Parwani; Alan Wells; Liron Pantanowitz; Zoltán N Oltvai
Workflow organization in pathology.
Clinics in laboratory medicine 2012;32(4):601-22.
2012: Aaron S Meyer; Alan Wells; Amalchi Castillo; Frank B Gertler; Shannon K Hughes-Alford; Jennifer E Kay; Douglas A Lauffenburger
2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen.
The Journal of cell biology 2012;197(6):721-9.
2012: Alan Wells
Laboratory medicine: a view to the future of diagnostics and training.
Rinsho byori. The Japanese journal of clinical pathology 2012;60(4):312-20.
2012: Yvonne Chao; Rajiv Dhir; Marie Acquafondata; Qian Wu; Alan Wells
Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastases.
Cancer microenvironment : official journal of the International Cancer Microenvironment Society 2012;5(1):19-28.
2012: Melanie Rodrigues; Donna Stolz; Omari Turner; Linda G Griffith; Alan Wells
Production of reactive oxygen species by multipotent stromal cells/mesenchymal stem cells upon exposure to fas ligand.
Cell transplantation 2012;21(10):2171-87.
2012: Qian Wu; Rajiv Dhir; Alan Wells
Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion.
Molecular cancer 2012;11():3.
2012: Cecelia C Yates; Diana Whaley; Alan Wells
Transplanted fibroblasts prevents dysfunctional repair in a murine CXCR3-deficient scarring model.
Cell transplantation 2012;21(5):919-31.
2012: Yvonne Chao; Christopher Shepard; Qian Wu; Alan Wells
Hepatocyte induced re-expression of E-cadherin in breast and prostate cancer cells increases chemoresistance.
Clinical & experimental metastasis 2012;29(1):39-50.
2011: Shan Wu; Alan Wells; Linda G Griffith; Douglas A Lauffenburger
Controlling multipotent stromal cell migration by integrating "course-graining" materials and "fine-tuning" small molecules via decision tree signal-response modeling.
Biomaterials 2011;32(30):7524-31.
2011: Cecelia C Yates; Richard Bodnar; Alan Wells
Matrix control of scarring.
Cellular and molecular life sciences : CMLS 2011;68(11):1871-81.
2011: Alan Wells; Yvonne L Chao; Jelena Grahovac; Qian Wu; Douglas A Lauffenburger
Epithelial and mesenchymal phenotypic switchings modulate cell motility in metastasis.
Frontiers in bioscience : a journal and virtual library 2011;16():815-37.
2010: Yong Ho Bae; Zhijie Ding; Tuhin Das; Alan Wells; Frank Gertler; Partha Roy
Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21547-52.
2010: Alan Wells
Preface. Genetics of neurologic and psychiatric diseases.
Clinics in laboratory medicine 2010;30(4):xiii-xiv.
2010: Priya Krishna; Michael Regner; Joel Palko; Fang Liu; Steve Abramowitch; Jack Jiang; Alan Wells
The effects of decorin and HGF-primed vocal fold fibroblasts in vitro and ex vivo in a porcine model of vocal fold scarring.
The Laryngoscope 2010;120(11):2247-57.
2010: Cecelia C Yates; Priya Krishna; Diana Whaley; Richard Bodnar; Timothy Turner; Alan Wells
Lack of CXC chemokine receptor 3 signaling leads to hypertrophic and hypercellular scarring.
The American journal of pathology 2010;176(4):1743-55.
2010: Hanshuang Shao; Chuanyue Wu; Alan Wells
Phosphorylation of alpha-actinin 4 upon epidermal growth factor exposure regulates its interaction with actin.
The Journal of biological chemistry 2010;285(4):2591-600.
2010: Hanshuang Shao; James H-C Wang; Martin R Pollak; Alan Wells
α-actinin-4 is essential for maintaining the spreading, motility and contractility of fibroblasts.
PloS one 2010;5(11):e13921.
2010: Melanie Rodrigues; Linda G Griffith; Alan Wells
Growth factor regulation of proliferation and survival of multipotential stromal cells.
Stem cell research & therapy 2010;1(4):32.
2010: Yvonne L Chao; Christopher R Shepard; Alan Wells
Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition.
Molecular cancer 2010;9():179.
2010: Kenichi Tamama; Haruhisa Kawasaki; Alan Wells
Epidermal growth factor (EGF) treatment on multipotential stromal cells (MSCs). Possible enhancement of therapeutic potential of MSC.
Journal of biomedicine & biotechnology 2010;2010():795385.
2009: Manu Platt; Catera L Wilder; Alan Wells; Linda G Griffith; Douglas A Lauffenburger
Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells.
Stem cells (Dayton, Ohio) 2009;27(11):2804-14.
2009: Manu Platt; Arian J Roman; Alan Wells; Douglas A Lauffenburger; Linda G Griffith
Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells.
Journal of cellular physiology 2009;221(2):306-17.
2009: Zhijie Ding; David Gau; Bridget Deasy; Alan Wells; Partha Roy
Both actin and polyproline interactions of profilin-1 are required for migration, invasion and capillary morphogenesis of vascular endothelial cells.
Experimental cell research 2009;315(17):2963-73.
2009: Nicholas A Marcantonio; Cynthia Boehm; Richard J Rozic; Ada Au; Alan Wells; George F Muschler; Linda G Griffith
The influence of tethered epidermal growth factor on connective tissue progenitor colony formation.
Biomaterials 2009;30(27):4629-38.
2009: Yong Ho Bae; Zhijie Ding; Li Zou; Alan Wells; Frank Gertler; Partha Roy
Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins.
Journal of cellular physiology 2009;219(2):354-64.
2009: Tuhin Das; Yong Ho Bae; Alan Wells; Partha Roy
Profilin-1 overexpression upregulates PTEN and suppresses AKT activation in breast cancer cells.
Journal of cellular physiology 2009;218(2):436-43.
2009: Cecelia Yates; Diana Whaley; Shveta Hooda; Patricia A Hebda; Richard J Bodnar; Alan Wells
Delayed reepithelialization and basement membrane regeneration after wounding in mice lacking CXCR3.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2009;17(1):34-41.
2008: Hyung-Do Kim; Tiffany W Guo; Angela P Wu; Alan Wells; Frank B Gertler; Douglas A Lauffenburger
Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence.
Molecular biology of the cell 2008;19(10):4249-59.
2008: Kenichi Tamama; Chandan K Sen; Alan Wells
Differentiation of bone marrow mesenchymal stem cells into the smooth muscle lineage by blocking ERK/MAPK signaling pathway.
Stem cells and development 2008;17(5):897-908.
2008: Cecelia Yates; Diana Whaley; Amy Y-Chen; Priya Kulesekaran; Patricia A Hebda; Alan Wells
ELR-negative CXC chemokine CXCL11 (IP-9/I-TAC) facilitates dermal and epidermal maturation during wound repair.
The American journal of pathology 2008;173(3):643-52.
2008: Hanshuang Shao; Xiao-Ming Yi; Alan Wells
Epidermal growth factor protects fibroblasts from apoptosis via PI3 kinase and Rac signaling pathways.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2008;16(4):551-8.
2008: Anand Krishnan V Iyer; Kien T Tran; Linda Griffith; Alan Wells
Cell surface restriction of EGFR by a tenascin cytotactin-encoded EGF-like repeat is preferential for motility-related signaling.
Journal of cellular physiology 2008;214(2):504-12.
2008: Allison C Sharrow; Yanan Li; Amanda Micsenyi; Reed D Griswold; Alan Wells; Satdarshan Pal S. Monga; Harry C Blair
Modulation of osteoblast gap junction connectivity by serum, TNFalpha, and TRAIL.
Experimental cell research 2008;314(2):297-308.
2008: Alan Wells; Clayton Yates; Christopher Shepard
E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas.
Clinical & experimental metastasis 2008;25(6):621-8.
2007: L Zou; M Jaramillo; Diana Whaley; Alan Wells; V Panchapakesa; T Das; Partha Roy
Profilin-1 is a negative regulator of mammary carcinoma aggressiveness.
British journal of cancer 2007;97(10):1361-71.
2007: Cecelia Yates; Diana Whaley; Ranjith Babu; Jianying Zhang; Priya Krishna; Eric J Beckman; A William Pasculle; Alan Wells
The effect of multifunctional polymer-based gels on wound healing in full thickness bacteria-contaminated mouse skin wound models.
Biomaterials 2007;28(27):3977-86.
2007: Beatrice B Yaroslavskiy; Allison C Sharrow; Alan Wells; Lisa J Robinson; Harry C Blair
Necessity of inositol (1,4,5)-trisphosphate receptor 1 and mu-calpain in NO-induced osteoclast motility.
Journal of cell science 2007;120(Pt 16):2884-94.
2007: Cecelia Yates; Diana Whaley; Priya Kulasekeran; Wayne W Hancock; Bao Lu; Richard J Bodnar; Joseph Newsome; Patricia A Hebda; Alan Wells
Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor.
The American journal of pathology 2007;171(2):484-95.
2007: Harry C Blair; Alan Wells; Carlos M. Isales
Pituitary glycoprotein hormone receptors in non-endocrine organs.
Trends in endocrinology and metabolism: TEM 2007;18(6):227-33.
2007: Alan Wells; Brian R Smith
The goals of resident training in laboratory medicine in combined anatomic pathology/clinical pathology programs: an overview.
Clinics in laboratory medicine 2007;27(2):229-40; abstract v.
2007: Anand Krishnan V Iyer; Kien T Tran; Christopher W Borysenko; Michael Cascio; Carlos J Camacho; Harry C Blair; Ivet Bahar; Alan Wells
Tenascin cytotactin epidermal growth factor-like repeat binds epidermal growth factor receptor with low affinity.
Journal of cellular physiology 2007;211(3):748-58.
2007: Christopher Shepard; Jareer Kassis; Diana Whaley; Hyung-Gyoon Kim; Alan Wells
PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors.
Oncogene 2007;26(21):3020-6.
2007: Vivian H Fan; Kenichi Tamama; Ada Au; Romie Littrell; Llewellyn B Richardson; John W Wright; Alan Wells; Linda G Griffith
Tethered epidermal growth factor provides a survival advantage to mesenchymal stem cells.
Stem cells (Dayton, Ohio) 2007;25(5):1241-51.
2007: Clayton Yates; Christopher Shepard; D B Stolz; Alan Wells
Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin.
British journal of cancer 2007;96(8):1246-52.
2007: Clayton Yates; Christopher Shepard; Glenn D Papworth; Ajit Dash; Donna Beer-Stolz; Steven Tannenbaum; Linda Griffith; Alan Wells
Novel three-dimensional organotypic liver bioreactor to directly visualize early events in metastatic progression.
Advances in cancer research 2007;97():225-46.
2007: Sourabh Kharait; Sampsa Hautaniemi; Shan Wu; Akihiro Iwabu; Douglas A Lauffenburger; Alan Wells
Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility.
BMC systems biology 2007;1():9.
2006: Priya Krishna; Clark A Rosen; Ryan C Branski; Alan Wells; Patricia A Hebda
Primed fibroblasts and exogenous decorin: potential treatments for subacute vocal fold scar.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2006;135(6):937-45.
2006: Ranjith Babu; Jianying Zhang; Eric J Beckman; Mohammed Virji; William A Pasculle; Alan Wells
Antimicrobial activities of silver used as a polymerization catalyst for a wound-healing matrix.
Biomaterials 2006;27(24):4304-14.
2006: Latha Satish; James Lyons-Weiler; Patricia A Hebda; Alan Wells
Gene expression patterns in isolated keloid fibroblasts.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2006;14(4):463-70.
2006: Hanshuang Shao; Jeffrey Chou; Catherine J Baty; Nancy A Burke; simon simon watkins; Donna B Stolz; Alan Wells
Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activation.
Molecular and cellular biology 2006;26(14):5481-96.
2006: Alan Wells; Brian R Smith
Counterpoint: developing a clinical pathology curriculum to meet current and future needs.
Clinical chemistry 2006;52(6):971-2.
2006: Sourabh Kharait; Rajiv Dhir; Douglas A Lauffenburger; Alan Wells
Protein kinase Cdelta signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cells.
Biochemical and biophysical research communications 2006;343(3):848-56.
2006: Richard J Bodnar; Cecelia Yates; Alan Wells
IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain.
Circulation research 2006;98(5):617-25.
2006: Kenichi Tamama; Vivian H Fan; Linda G Griffith; Harry C Blair; Alan Wells
Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells.
Stem cells (Dayton, Ohio) 2006;24(3):686-95.
2006: Guoying Yu; Chien Cheng (George) Tseng; Yan Ping Yu; Tim Gavel; Joel Nelson; Alan Wells; George K Michalopoulos; Demetrius M Kokkinakis; Jian-Hua Luo
CSR1 suppresses tumor growth and metastasis of prostate cancer.
The American journal of pathology 2006;168(2):597-607.
2006: Alan Wells; Brian Harms; Akihiro Iwabu; Lily Koo; Kirsty Smith; Linda Griffith; Douglas A Lauffenburger
Motility signaled from the EGF receptor and related systems.
Methods in molecular biology (Clifton, N.J.) 2006;327():159-77.
2005: Jun Wang; Xin Zhang; Sufi Thomas; Jennifer Rubin Grandis; Alan Wells; Zhuo Georgia Chen; Robert L Ferris
Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR.
Oncogene 2005;24(38):5897-904.
2005: Stephen Y Lai; Erin E Childs; Sichuan Xi; Francesca M Coppelli; William Gooding; Alan Wells; Robert L Ferris; Jennifer Rubin Grandis
Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma.
Oncogene 2005;24(27):4442-9.
2005: Sampsa Hautaniemi; Sourabh Kharait; Akihiro Iwabu; Alan Wells; Douglas A Lauffenburger
Modeling of signal-response cascades using decision tree analysis.
Bioinformatics (Oxford, England) 2005;21(9):2027-35.
2005: Latha Satish; Harry C Blair; Angela Glading; Alan Wells
Interferon-inducible protein 9 (CXCL11)-induced cell motility in keratinocytes requires calcium flux-dependent activation of mu-calpain.
Molecular and cellular biology 2005;25(5):1922-41.
2005: Bart S Hendriks; Galya Orr; Alan Wells; H Steven Wiley; Douglas A Lauffenburger
Parsing ERK activation reveals quantitatively equivalent contributions from epidermal growth factor receptor and HER2 in human mammary epithelial cells.
The Journal of biological chemistry 2005;280(7):6157-69.
2005: Clayton Yates; Alan Wells; T Turner
Luteinising hormone-releasing hormone analogue reverses the cell adhesion profile of EGFR overexpressing DU-145 human prostate carcinoma subline.
British journal of cancer 2005;92(2):366-75.
2005: Alan Wells; Anna Huttenlocher; Douglas A Lauffenburger
Calpain proteases in cell adhesion and motility.
International review of cytology 2005;245():1-16.
2004: Asmaa Mamoune; Jareer Kassis; Sourabh Kharait; Susanne Kloeker; Elizabeth J Manos; David A Jones; Alan Wells
DU145 human prostate carcinoma invasiveness is modulated by urokinase receptor (uPAR) downstream of epidermal growth factor receptor (EGFR) signaling.
Experimental cell research 2004;299(1):91-100.
2004: Paul Kornblith; Robert L Ochs; Alan Wells; Michael J Gabrin; John Piwowar; A Chattopadhyay; Lisa D George; Dennis Burholt
Differential in vitro effects of chemotherapeutic agents on primary cultures of human ovarian carcinoma.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2004;14(4):607-15.
2004: Yukako Yagi; Ishtiaque Ahmed; William Gross; Michael Becich; Anthony J Demetris; Alan Wells; Clayton A Wiley; George K Michalopoulos; Samuel A Yousem; Barbara Barnes; John R Gilbertson
Webcasting pathology department conferences in a geographically distributed medical center.
Human pathology 2004;35(7):790-7.
2004: Kien T Tran; Linda Griffith; Alan Wells
Extracellular matrix signaling through growth factor receptors during wound healing.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2004;12(3):262-8.
2004: Ling Jing; Lijun Liu; Yan Ping Yu; Rajiv Dhir; Marie Acquafondada; Douglas Landsittel; Kathleen Cieply; Alan Wells; Jian-Hua Luo
Expression of myopodin induces suppression of tumor growth and metastasis.
The American journal of pathology 2004;164(5):1799-806.
2004: Akihiro Iwabu; Kirsty Smith; Fred D Allen; Douglas A Lauffenburger; Alan Wells
Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway.
The Journal of biological chemistry 2004;279(15):14551-60.
2004: Latha Satish; Mary Babu; Kien T Tran; Patricia A Hebda; Alan Wells
Keloid fibroblast responsiveness to epidermal growth factor and activation of downstream intracellular signaling pathways.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2004;12(2):183-92.
2004: Angela Glading; Richard J Bodnar; I J Reynolds; Hidenori Shiraha; Latha Satish; D A Potter; Harry C Blair; Alan Wells
Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation.
Molecular and cellular biology 2004;24(6):2499-512.
2003: Kien T Tran; S Diana Rusu; Latha Satish; Alan Wells
Aging-related attenuation of EGF receptor signaling is mediated in part by increased protein tyrosine phosphatase activity.
Experimental cell research 2003;289(2):359-67.
2003: Sufi Thomas; Francesca M Coppelli; Alan Wells; William Gooding; John Song; Jareer Kassis; Stephanie D Drenning; Jennifer Rubin Grandis
Epidermal growth factor receptor-stimulated activation of phospholipase Cgamma-1 promotes invasion of head and neck squamous cell carcinoma.
Cancer research 2003;63(17):5629-35.
2003: Patricia A Hebda; Diana Whaley; Hyung-Gyoon Kim; Alan Wells
Absence of inhibition of cutaneous wound healing in mice by oral doxycycline.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2003;11(5):373-9.
2003: Asmaa Mamoune; Jian-Hua Luo; Douglas A Lauffenburger; Alan Wells
Calpain-2 as a target for limiting prostate cancer invasion.
Cancer research 2003;63(15):4632-40.
2003: Paul Kornblith; Alan Wells; Michael J Gabrin; John Piwowar; Lisa D George; Robert L Ochs; Dennis Burholt
Breast cancer--response rates to chemotherapeutic agents studied in vitro.
Anticancer research 2003;23(4):3405-11.
2003: Jeffrey Chou; Nancy A Burke; Akihiro Iwabu; simon simon watkins; Alan Wells
Directional motility induced by epidermal growth factor requires Cdc42.
Experimental cell research 2003;287(1):47-56.
2003: Latha Satish; Dorne R Yager; Alan Wells
Glu-Leu-Arg-negative CXC chemokine interferon gamma inducible protein-9 as a mediator of epidermal-dermal communication during wound repair.
The Journal of investigative dermatology 2003;120(6):1110-7.
2003: Douglas A Lauffenburger; Alan Wells
Quantitative parsing of cell multi-tasking in wound repair and tissue morphogenesis.
Biophysical journal 2003;84(6):3499-500.
2003: Robert L Ochs; Jeffrey Fensterer; N Paul Ohori; Alan Wells; Michael J Gabrin; Lisa D George; Paul Kornblith
Evidence for the isolation, growth, and characterization of malignant cells in primary cultures of human tumors.
In vitro cellular & developmental biology. Animal 2003;39(1-2):63-70.
2003: Paul Kornblith; Alan Wells; Michael J Gabrin; John Piwowar; Anuja Chattopadhyay; Lisa D George; Robert L Ochs; Dennis Burholt
In vitro responses of ovarian cancers to platinums and taxanes.
Anticancer research 2003;23(1B):543-8.
2002: Alan Wells; Ulrich Marti
Signalling shortcuts: cell-surface receptors in the nucleus?
Nature reviews. Molecular cell biology 2002;3(9):697-702.
2002: Jeffrey Chou; Donna B Stolz; Nancy A Burke; simon simon watkins; Alan Wells
Distribution of gelsolin and phosphoinositol 4,5-bisphosphate in lamellipodia during EGF-induced motility.
The international journal of biochemistry & cell biology 2002;34(7):776-90.
2002: Jareer Kassis; Robert Radinsky; Alan Wells
Motility is rate-limiting for invasion of bladder carcinoma cell lines.
The international journal of biochemistry & cell biology 2002;34(7):762-75.
2002: Jareer Kassis; Akihiko Maeda; Norihiro Teramoto; Kenzo Takada; Chuanyue Wu; George Klein; Alan Wells
EBV-expressing AGS gastric carcinoma cell sublines present increased motility and invasiveness.
International journal of cancer. Journal international du cancer 2002;99(5):644-51.
2002: Alan Wells; Jose Carlos S Souto; James Solava; Jareer Kassis; Karlyn J Bailey; Timothy Turner
Luteinizing hormone-releasing hormone agonist limits DU-145 prostate cancer growth by attenuating epidermal growth factor receptor signaling.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(4):1251-7.
2002: Hidenori Shiraha; Angela Glading; Jeffrey Chou; Zongchao Jia; Alan Wells
Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain.
Molecular and cellular biology 2002;22(8):2716-27.
2002: Alan Wells; Jareer Kassis; James Solava; Timothy Turner; Douglas A Lauffenburger
Growth factor-induced cell motility in tumor invasion.
Acta oncologica (Stockholm, Sweden) 2002;41(2):124-30.
2002: Fred D Allen; Clara F Asnes; Philip Chang; Elliot L Elson; Douglas A Lauffenburger; Alan Wells
Epidermal growth factor induces acute matrix contraction and subsequent calpain-modulated relaxation.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2002;10(1):67-76.
2002: Angela Glading; Douglas A Lauffenburger; Alan Wells
Cutting to the chase: calpain proteases in cell motility.
Trends in cell biology 2002;12(1):46-54.
2001: C Scott Swindle; Kien T Tran; T D Johnson; P Banerjee; A M Mayes; Linda Griffith; Alan Wells
Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor.
The Journal of cell biology 2001;154(2):459-68.
2001: Angela Glading; Florian Uberall; S M Keyse; Douglas A Lauffenburger; Alan Wells
Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling.
The Journal of biological chemistry 2001;276(26):23341-8.
2001: Elizabeth J Manos; M L Kim; J Kassis; P Y Chang; Alan Wells; David A Jones
Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase C-gamma regulated gene negatively associated with prostate tumor invasion.
Oncogene 2001;20(22):2781-90.
2001: Jareer Kassis; Douglas A Lauffenburger; Timothy Turner; Alan Wells
Tumor invasion as dysregulated cell motility.
Seminars in cancer biology 2001;11(2):105-17.
2000: JM Haugh; Alan Wells; Douglas A Lauffenburger
Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: mechanistic insights and predictions for molecular interventions.
Biotechnology and bioengineering 2000;70(2):225-38.
2000: Steven S Rosenfeld; Jun Xing; M Whitaker; Herbert C Cheung; F Brown; Alan Wells; R A Milligan; H Lee Sweeney
Kinetic and spectroscopic evidence for three actomyosin:ADP states in smooth muscle.
The Journal of biological chemistry 2000;275(33):25418-26.
2000: Hidenori Shiraha; K Gupta; K Drabik; Alan Wells
Aging fibroblasts present reduced epidermal growth factor (EGF) responsiveness due to preferential loss of EGF receptors.
The Journal of biological chemistry 2000;275(25):19343-51.
2000: G Maheshwari; G Brown; Douglas A Lauffenburger; Alan Wells; Linda G Griffith
Cell adhesion and motility depend on nanoscale RGD clustering.
Journal of cell science 2000;113 ( Pt 10)():1677-86.
2000: Angela Glading; P Chang; Douglas A Lauffenburger; Alan Wells
Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway.
The Journal of biological chemistry 2000;275(4):2390-8.
2000: Alan Wells
Tumor invasion: role of growth factor-induced cell motility.
Advances in cancer research 2000;78():31-101.
1999: Alan Wells; M F Ware; F D Allen; Douglas A Lauffenburger
Shaping up for shipping out: PLCgamma signaling of morphology changes in EGF-stimulated fibroblast migration.
Cell motility and the cytoskeleton 1999;44(4):227-33.
1999: JM Haugh; A C Huang; H Steven Wiley; Alan Wells; Douglas A Lauffenburger
Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts.
The Journal of biological chemistry 1999;274(48):34350-60.
1999: Hyung-Gyoon Kim; Jareer Kassis; J C Souto; Timothy Turner; Alan Wells
EGF receptor signaling in prostate morphogenesis and tumorigenesis.
Histology and histopathology 1999;14(4):1175-82.
1999: Jareer Kassis; J Moellinger; H Lo; N M Greenberg; Hyung-Gyoon Kim; Alan Wells
A role for phospholipase C-gamma-mediated signaling in tumor cell invasion.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(8):2251-60.
1999: Hidenori Shiraha; Angela Glading; K Gupta; Alan Wells
IP-10 inhibits epidermal growth factor-induced motility by decreasing epidermal growth factor receptor-mediated calpain activity.
The Journal of cell biology 1999;146(1):243-54.
1999: Alan Wells
EGF receptor.
The international journal of biochemistry & cell biology 1999;31(6):637-43.
1999: G Maheshwari; Alan Wells; Linda G Griffith; Douglas A Lauffenburger
Biophysical integration of effects of epidermal growth factor and fibronectin on fibroblast migration.
Biophysical journal 1999;76(5):2814-23.
1999: JM Haugh; K Schooler; Alan Wells; H Steven Wiley; Douglas A Lauffenburger
Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway.
The Journal of biological chemistry 1999;274(13):8958-65.
1998: Alan Wells; K Gupta; P Chang; S Swindle; Angela Glading; Hidenori Shiraha
Epidermal growth factor receptor-mediated motility in fibroblasts.
Microscopy research and technique 1998;43(5):395-411.
1998: M F Ware; Alan Wells; Douglas A Lauffenburger
Epidermal growth factor alters fibroblast migration speed and directional persistence reciprocally and in a matrix-dependent manner.
Journal of cell science 1998;111 ( Pt 16)():2423-32.
1998: H Xie; Manuel Antonio Pallero; K Gupta; P Chang; M F Ware; W Witke; D J Kwiatkowski; D A Lauffenburger; Joanne E Murphy-Ullrich; Alan Wells
EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCgamma signaling pathway.
Journal of cell science 1998;111 ( Pt 5)():615-24.
1997: Timothy Turner; M V Epps-Fung; Jareer Kassis; Alan Wells
Molecular inhibition of phospholipase cgamma signaling abrogates DU-145 prostate tumor cell invasion.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(12 Pt 1):2275-82.
1997: M Zhang; M H Wang; Raj K Singh; Alan Wells; G P Siegal
Epidermal growth factor induces CD44 gene expression through a novel regulatory element in mouse fibroblasts.
The Journal of biological chemistry 1997;272(22):14139-46.
1996: P Chen; Joanne E Murphy-Ullrich; Alan Wells
A role for gelsolin in actuating epidermal growth factor receptor-mediated cell motility.
The Journal of cell biology 1996;134(3):689-98.
1996: P Chen; H Xie; Alan Wells
Mitogenic signaling from the egf receptor is attenuated by a phospholipase C-gamma/protein kinase C feedback mechanism.
Molecular biology of the cell 1996;7(6):871-81.
1994: P Chen; H Xie; MC Sekar; K Gupta; Alan Wells
Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement.
The Journal of cell biology 1994;127(3):847-57.
1994: P Chen; K Gupta; Alan Wells
Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis.
The Journal of cell biology 1994;124(4):547-55.