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Robert Wells

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Urszula Polak; Robert D Wells; Sharon Y R Dent; Elizabeth McIvor; Marek Napierala
Expanded complexity of unstable repeat diseases.
Yunfu Lin; Sharon Y R Dent; John H Wilson; Robert D Wells; Marek Napierala
R loops stimulate genetic instability of CTG.CAG repeats.
Nadia Chuzhanova; Jian-Min Chen; Albino Bacolla; George P Patrinos; Claude Férec; Robert D Wells; David N Cooper
Gene conversion causing human inherited disease: evidence for involvement of non-B-DNA-forming sequences and recombination-promoting motifs in DNA breakage and repair.

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All Publications

2013: Urszula Polak; Robert D Wells; Sharon Y R Dent; Elizabeth McIvor; Marek Napierala
Expanded complexity of unstable repeat diseases.
BioFactors (Oxford, England) 2013;39(2):164-75.
2010: Yunfu Lin; Sharon Y R Dent; John H Wilson; Robert D Wells; Marek Napierala
R loops stimulate genetic instability of CTG.CAG repeats.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):692-7.
2009: Nadia Chuzhanova; Jian-Min Chen; Albino Bacolla; George P Patrinos; Claude Férec; Robert D Wells; David N Cooper
Gene conversion causing human inherited disease: evidence for involvement of non-B-DNA-forming sequences and recombination-promoting motifs in DNA breakage and repair.
Human mutation 2009;30(8):1189-98.
2009: Robert D Wells
Discovery of the role of non-B DNA structures in mutagenesis and human genomic disorders.
The Journal of biological chemistry 2009;284(14):8997-9009.
2009: Albino Bacolla; Robert D Wells
Non-B DNA conformations as determinants of mutagenesis and human disease.
Molecular carcinogenesis 2009;48(4):273-85.
2009: Robert D Wells
Mutation spectra in fragile X syndrome induced by deletions of CGG*CCG repeats.
The Journal of biological chemistry 2009;284(12):7407-11.
2008: E Soragni; D Herman; S Y R Dent; J M Gottesfeld; Robert D Wells; Marek Napierala
Long intronic GAA*TTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia.
Nucleic acids research 2008;36(19):6056-65.
2008: Albino Bacolla; Jacquelynn E Larson; Jack R Collins; Jian Li; Aleksandar Milosavljevic; Peter D Stenson; David N Cooper; Robert D Wells
Abundance and length of simple repeats in vertebrate genomes are determined by their structural properties.
Genome research 2008;18(10):1545-53.
2008: Robert D Wells
DNA triplexes and Friedreich ataxia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(6):1625-34.
2007: Beata Kosmider; Robert D Wells
Fragile X repeats are potent inducers of complex, multiple site rearrangements in flanking sequences in Escherichia coli.
DNA repair 2007;6(12):1850-63.
2007: Robert D Wells
Non-B DNA conformations, mutagenesis and disease.
Trends in biochemical sciences 2007;32(6):271-8.
2006: Albino Bacolla; Marzena Wojciechowska; Beata Kosmider; Jacquelynn E Larson; Robert D Wells
The involvement of non-B DNA structures in gross chromosomal rearrangements.
DNA repair 2006;5(9-10):1161-70.
2006: Marzena Wojciechowska; Marek Napierala; Jacquelynn E Larson; Robert D Wells
Non-B DNA conformations formed by long repeating tracts of myotonic dystrophy type 1, myotonic dystrophy type 2, and Friedreich's ataxia genes, not the sequences per se, promote mutagenesis in flanking regions.
The Journal of biological chemistry 2006;281(34):24531-43.
2006: Ryan Burnett; Christian Melander; James W Puckett; Leslie S Son; Robert D Wells; Peter B Dervan; Joel M Gottesfeld
DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11497-502.
2006: Leslie S Son; Albino Bacolla; Robert D Wells
Sticky DNA: in vivo formation in E. coli and in vitro association of long GAA*TTC tracts to generate two independent supercoiled domains.
Journal of molecular biology 2006;360(2):267-84.
2006: Ruhee Dere; Robert D Wells
DM2 CCTG*CAGG repeats are crossover hotspots that are more prone to expansions than the DM1 CTG*CAG repeats in Escherichia coli.
Journal of molecular biology 2006;360(1):21-36.
2006: Beata Kosmider; Robert D Wells
Double-strand breaks in the myotonic dystrophy type 1 and the fragile X syndrome triplet repeat sequences induce different types of mutations in DNA flanking sequences in Escherichia coli.
Nucleic acids research 2006;34(19):5369-82.
2006: Albino Bacolla; Jack R Collins; Bert Gold; Nadia Chuzhanova; Ming Yi; Robert M Stephens; Stefan Stefanov; Adam Olsh; John Jakupciak; Michael Dean; Richard A Lempicki; David N Cooper; Robert D Wells
Long homopurine*homopyrimidine sequences are characteristic of genes expressed in brain and the pseudoautosomal region.
Nucleic acids research 2006;34(9):2663-75.
2005: Micheal L Hebert; Robert D Wells
Roles of double-strand breaks, nicks, and gaps in stimulating deletions of CTG.CAG repeats by intramolecular DNA repair.
Journal of molecular biology 2005;353(5):961-79.
2005: Marek Napierala; Albino Bacolla; Robert D Wells
Increased negative superhelical density in vivo enhances the genetic instability of triplet repeat sequences.
The Journal of biological chemistry 2005;280(45):37366-76.
2005: Marzena Wojciechowska; Albino Bacolla; Jacquelynn E Larson; Robert D Wells
The myotonic dystrophy type 1 triplet repeat sequence induces gross deletions and inversions.
The Journal of biological chemistry 2005;280(2):941-52.
2005: Robert D Wells; Ruhee Dere; Micheal L Hebert; Marek Napierala; Leslie S Son
Advances in mechanisms of genetic instability related to hereditary neurological diseases.
Nucleic acids research 2005;33(12):3785-98.
2004: Albino Bacolla; Robert D Wells
Non-B DNA conformations, genomic rearrangements, and human disease.
The Journal of biological chemistry 2004;279(46):47411-4.
2004: Ruhee Dere; Marek Napierala; Laura P W Ranum; Robert D Wells
Hairpin structure-forming propensity of the (CCTG.CAGG) tetranucleotide repeats contributes to the genetic instability associated with myotonic dystrophy type 2.
The Journal of biological chemistry 2004;279(40):41715-26.
2004: Albino Bacolla; Adam Jaworski; Jacquelynn E Larson; John Jakupciak; Nadia Chuzhanova; Shaun S Abeysinghe; Catherine D O'Connell; David N Cooper; Robert D Wells
Breakpoints of gross deletions coincide with non-B DNA conformations.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(39):14162-7.
2004: Micheal L Hebert; Leslie A Spitz; Robert D Wells
DNA double-strand breaks induce deletion of CTG.CAG repeats in an orientation-dependent manner in Escherichia coli.
Journal of molecular biology 2004;336(3):655-72.
2004: Alexandre A Vetcher; Robert D Wells
Sticky DNA formation in vivo alters the plasmid dimer/monomer ratio.
The Journal of biological chemistry 2004;279(8):6434-43.
2004: Marek Napierala; Ruhee Dere; Alexandre A Vetcher; Robert D Wells
Structure-dependent recombination hot spot activity of GAA.TTC sequences from intron 1 of the Friedreich's ataxia gene.
The Journal of biological chemistry 2004;279(8):6444-54.
2004: Liliana H Mochmann; Robert D Wells
Transcription influences the types of deletion and expansion products in an orientation-dependent manner from GAC*GTC repeats.
Nucleic acids research 2004;32(15):4469-79.
2003: James L Meservy; R Geoffrey Sargent; Ravi R Iyer; Fung Chan; Gregory J McKenzie; Robert D Wells; John H Wilson
Long CTG tracts from the myotonic dystrophy gene induce deletions and rearrangements during recombination at the APRT locus in CHO cells.
Molecular and cellular biology 2003;23(9):3152-62.
2002: Alexandre A Vetcher; Marek Napierala; Robert D Wells
Sticky DNA: effect of the polypurine.polypyrimidine sequence.
The Journal of biological chemistry 2002;277(42):39228-34.
2002: Alexandre A Vetcher; Marek Napierala; Ravi R Iyer; Paul Chastain; Jack D Griffith; Robert D Wells
Sticky DNA, a long GAA.GAA.TTC triplex that is formed intramolecularly, in the sequence of intron 1 of the frataxin gene.
The Journal of biological chemistry 2002;277(42):39217-27.
2002: Anna Pluciennik; Ravi R Iyer; Marek Napierala; Jacquelynn E Larson; Marcin Filutowicz; Robert D Wells
Long CTG.CAG repeats from myotonic dystrophy are preferred sites for intermolecular recombination.
The Journal of biological chemistry 2002;277(37):34074-86.
2002: Marek Napierala; Pawel Parniewski; Anna Pluciennik; Robert D Wells
Long CTG.CAG repeat sequences markedly stimulate intramolecular recombination.
The Journal of biological chemistry 2002;277(37):34087-100.
2002: Robert D Wells
How I became a biochemist.
IUBMB life 2002;53(2):137-8.
2001: N Sakamoto; Keiichi Ohshima; L Montermini; Massimo Pandolfo; Robert D Wells
Sticky DNA, a self-associated complex formed at long GAA*TTC repeats in intron 1 of the frataxin gene, inhibits transcription.
The Journal of biological chemistry 2001;276(29):27171-7.
2001: N Sakamoto; Jacquelynn E Larson; Ravi R Iyer; L Montermini; Massimo Pandolfo; Robert D Wells
GGA*TCC-interrupted triplets in long GAA*TTC repeats inhibit the formation of triplex and sticky DNA structures, alleviate transcription inhibition, and reduce genetic instabilities.
The Journal of biological chemistry 2001;276(29):27178-87.
2001: Albino Bacolla; S Pradhan; Jacquelynn E Larson; Richard J Roberts; Robert D Wells
Recombinant human DNA (cytosine-5) methyltransferase. III. Allosteric control, reaction order, and influence of plasmid topology and triplet repeat length on methylation of the fragile X CGG.CCG sequence.
The Journal of biological chemistry 2001;276(21):18605-13.
2001: Albino Bacolla; Adam Jaworski; T D Connors; Robert D Wells
Pkd1 unusual DNA conformations are recognized by nucleotide excision repair.
The Journal of biological chemistry 2001;276(21):18597-604.
2001: Richard P Bowater; Robert D Wells
The intrinsically unstable life of DNA triplet repeats associated with human hereditary disorders.
Progress in nucleic acid research and molecular biology 2001;66():159-202.
2000: John Jakupciak; Robert D Wells
Gene conversion (recombination) mediates expansions of CTG[middle dot]CAG repeats.
The Journal of biological chemistry 2000;275(51):40003-13.
2000: John Jakupciak; Robert D Wells
Genetic instabilities of triplet repeat sequences by recombination.
IUBMB life 2000;50(6):355-9.
2000: Anna Pluciennik; Ravi R Iyer; Pawel Parniewski; Robert D Wells
Tandem duplication. A novel type of triplet repeat instability.
The Journal of biological chemistry 2000;275(37):28386-97.
2000: Pawel Parniewski; Adam Jaworski; Robert D Wells; Richard P Bowater
Length of CTG.CAG repeats determines the influence of mismatch repair on genetic instability.
Journal of molecular biology 2000;299(4):865-74.
2000: Ravi R Iyer; Anna Pluciennik; William A Rosche; Richard R Sinden; Robert D Wells
DNA polymerase III proofreading mutants enhance the expansion and deletion of triplet repeat sequences in Escherichia coli.
The Journal of biological chemistry 2000;275(3):2174-84.
1999: Albino Bacolla; S Pradhan; Richard J Roberts; Robert D Wells
Recombinant human DNA (cytosine-5) methyltransferase. II. Steady-state kinetics reveal allosteric activation by methylated dna.
The Journal of biological chemistry 1999;274(46):33011-9.
1999: S Pradhan; Albino Bacolla; Robert D Wells; Richard J Roberts
Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation.
The Journal of biological chemistry 1999;274(46):33002-10.
1999: Keiichi Ohshima; N Sakamoto; M Labuda; J Poirier; Melinda L Moseley; L Montermini; Laura P W Ranum; Robert D Wells; Massimo Pandolfo
A nonpathogenic GAAGGA repeat in the Friedreich gene: implications for pathogenesis.
Neurology 1999;53(8):1854-7.
1999: John Jakupciak; Robert D Wells
Genetic instabilities in (CTG.CAG) repeats occur by recombination.
The Journal of biological chemistry 1999;274(33):23468-79.
1999: N Sakamoto; Paul Chastain; Pawel Parniewski; K Ohshima; M Pandolfo; Jack D Griffith; Robert D Wells
Sticky DNA: self-association properties of long GAA.TTC repeats in R.R.Y triplex structures from Friedreich's ataxia.
Molecular cell 1999;3(4):465-75.
1999: Ravi R Iyer; Robert D Wells
Expansion and deletion of triplet repeat sequences in Escherichia coli occur on the leading strand of DNA replication.
The Journal of biological chemistry 1999;274(6):3865-77.
1999: Pawel Parniewski; Albino Bacolla; Adam Jaworski; Robert D Wells
Nucleotide excision repair affects the stability of long transcribed (CTG*CAG) tracts in an orientation-dependent manner in Escherichia coli.
Nucleic acids research 1999;27(2):616-23.
1998: Robert D Wells; Pawel Parniewski; Anna Pluciennik; Albino Bacolla; R Gellibolian; Adam Jaworski
Small slipped register genetic instabilities in Escherichia coli in triplet repeat sequences associated with hereditary neurological diseases.
The Journal of biological chemistry 1998;273(31):19532-41.
1998: Keiichi Ohshima; L Montermini; Robert D Wells; Massimo Pandolfo
Inhibitory effects of expanded GAA.TTC triplet repeats from intron I of the Friedreich ataxia gene on transcription and replication in vivo.
The Journal of biological chemistry 1998;273(23):14588-95.
1998: Robert D Wells; Albino Bacolla; Richard P Bowater
Instabilities of triplet repeats: factors and mechanisms.
Results and problems in cell differentiation 1998;21():133-65.
1997: Richard P Bowater; Adam Jaworski; Jacquelynn E Larson; Pawel Parniewski; Robert D Wells
Transcription increases the deletion frequency of long CTG.CAG triplet repeats from plasmids in Escherichia coli.
Nucleic acids research 1997;25(14):2861-8.
1997: K Ohshima; Robert D Wells
Hairpin formation during DNA synthesis primer realignment in vitro in triplet repeat sequences from human hereditary disease genes.
The Journal of biological chemistry 1997;272(27):16798-806.
1997: R Gellibolian; Albino Bacolla; Robert D Wells
Triplet repeat instability and DNA topology: an expansion model based on statistical mechanics.
The Journal of biological chemistry 1997;272(27):16793-7.
1997: Albino Bacolla; R Gellibolian; M Shimizu; S Amirhaeri; S Kang; K Ohshima; Jacquelynn E Larson; Stephen C Harvey; B D Stollar; Robert D Wells
Flexible DNA: genetically unstable CTG.CAG and CGG.CCG from human hereditary neuromuscular disease genes.
The Journal of biological chemistry 1997;272(27):16783-92.
1996: R P Bowater; William A Rosche; Adam Jaworski; Richard R Sinden; Robert D Wells
Relationship between Escherichia coli growth and deletions of CTG.CAG triplet repeats in plasmids.
Journal of molecular biology 1996;264(1):82-96.
1996: William A Rosche; Adam Jaworski; S Kang; S F Kramer; J E Larson; D P Geidroc; Robert D Wells; Richard R Sinden
Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli.
Journal of bacteriology 1996;178(16):5042-4.
1996: K Ohshima; S Kang; J E Larson; Robert D Wells
TTA.TAA triplet repeats in plasmids form a non-H bonded structure.
The Journal of biological chemistry 1996;271(28):16784-91.
1996: K Ohshima; S Kang; J E Larson; Robert D Wells
Cloning, characterization, and properties of seven triplet repeat DNA sequences.
The Journal of biological chemistry 1996;271(28):16773-83.
1996: S Kang; K Ohshima; Adam Jaworski; Robert D Wells
CTG triplet repeats from the myotonic dystrophy gene are expanded in Escherichia coli distal to the replication origin as a single large event.
Journal of molecular biology 1996;258(4):543-7.
1996: Robert D Wells
Molecular basis of genetic instability of triplet repeats.
The Journal of biological chemistry 1996;271(6):2875-8.
1996: K Ohshima; S Kang; Robert D Wells
CTG triplet repeats from human hereditary diseases are dominant genetic expansion products in Escherichia coli.
The Journal of biological chemistry 1996;271(4):1853-6.
1995: Adam Jaworski; William A Rosche; R Gellibolian; S Kang; M Shimizu; R P Bowater; Richard R Sinden; Robert D Wells
Mismatch repair in Escherichia coli enhances instability of (CTG)n triplet repeats from human hereditary diseases.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):11019-23.
1995: S Kang; K Ohshima; M Shimizu; S Amirhaeri; Robert D Wells
Pausing of DNA synthesis in vitro at specific loci in CTG and CGG triplet repeats from human hereditary disease genes.
The Journal of biological chemistry 1995;270(45):27014-21.
1995: Albino Bacolla; M J Ulrich; J E Larson; Timothy J Ley; Robert D Wells
An intramolecular triplex in the human gamma-globin 5'-flanking region is altered by point mutations associated with hereditary persistence of fetal hemoglobin.
The Journal of biological chemistry 1995;270(41):24556-63.
1995: S Kang; A Jaworski; K Ohshima; Robert D Wells
Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli.
Nature genetics 1995;10(2):213-8.
1995: S Amirhaeri; F Wohlrab; Robert D Wells
Differential effects of simple repeating DNA sequences on gene expression from the SV40 early promoter.
The Journal of biological chemistry 1995;270(7):3313-9.
1994: S Lukomski; Robert D Wells
Left-handed Z-DNA and in vivo supercoil density in the Escherichia coli chromosome.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):9980-4.
1994: S Kang; Robert D Wells
Zinc destabilizes DNA Watson-Crick pairs at AGCT.
The Journal of biological chemistry 1994;269(13):9528-32.
1992: S Kang; Robert D Wells
Central non-Pur.Pyr sequences in oligo(dG.dC) tracts and metal ions influence the formation of intramolecular DNA triplex isomers.
The Journal of biological chemistry 1992;267(29):20887-91.
1992: S Kang; F Wohlrab; Robert D Wells
GC-rich flanking tracts decrease the kinetics of intramolecular DNA triplex formation.
The Journal of biological chemistry 1992;267(27):19435-42.
1992: I G Panyutin; Robert D Wells
Nodule DNA in the (GA)37.(CT)37 insert in superhelical plasmids.
The Journal of biological chemistry 1992;267(8):5495-501.
1992: D A Hartman; SR Kuo; Thomas R Broker; Louise T Chow; Robert D Wells
Intermolecular triplex formation distorts the DNA duplex in the regulatory region of human papillomavirus type-11.
The Journal of biological chemistry 1992;267(8):5488-94.
1992: S M Kang; F Wohlrab; Robert D Wells
Metal ions cause the isomerization of certain intramolecular triplexes.
The Journal of biological chemistry 1992;267(2):1259-64.
1992: A R Rahmouni; Robert D Wells
Direct evidence for the effect of transcription on local DNA supercoiling in vivo.
Journal of molecular biology 1992;223(1):131-44.
1991: S Venditti; Robert D Wells
A DNA conformational alteration induced by a neighboring oligopurine tract on GAATTA enables nicking by EcoRI.
The Journal of biological chemistry 1991;266(25):16786-90.
1991: F Wohlrab; S Chatterjee; Robert D Wells
The herpes simplex virus 1 segment inversion site is specifically cleaved by a virus-induced nuclear endonuclease.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6432-6.
1991: Adam Jaworski; N Patrick Higgins; Robert D Wells; W Zacharias
Topoisomerase mutants and physiological conditions control supercoiling and Z-DNA formation in vivo.
The Journal of biological chemistry 1991;266(4):2576-81.
1990: A Bianchi; Robert D Wells; Nicholas H Heintz; M S Caddle
Sequences near the origin of replication of the DHFR locus of Chinese hamster ovary cells adopt left-handed Z-DNA and triplex structures.
The Journal of biological chemistry 1990;265(35):21789-96.
1990: M Rajagopalan; A R Rahmouni; Robert D Wells
Flanking AT-rich tracts cause a structural distortion in Z-DNA in plasmids.
The Journal of biological chemistry 1990;265(28):17294-9.
1990: D A Collier; Robert D Wells
Effect of length, supercoiling, and pH on intramolecular triplex formation. Multiple conformers at pur.pyr mirror repeats.
The Journal of biological chemistry 1990;265(18):10652-8.
1990: W Zacharias; Adam Jaworski; Robert D Wells
Cytosine methylation enhances Z-DNA formation in vivo.
Journal of bacteriology 1990;172(6):3278-83.
1990: M Shimizu; J C Hanvey; Robert D Wells
Multiple non-B-DNA conformations of polypurine.polypyrimidine sequences in plasmids.
Biochemistry 1990;29(19):4704-13.
1990: J C Hanvey; M Shimizu; Robert D Wells
Site-specific inhibition of EcoRI restriction/modification enzymes by a DNA triple helix.
Nucleic acids research 1990;18(1):157-61.
1989: A R Rahmouni; Robert D Wells
Stabilization of Z DNA in vivo by localized supercoiling.
Science (New York, N.Y.) 1989;246(4928):358-63.
1989: Adam Jaworski; J A Blaho; J E Larson; M Shimizu; Robert D Wells
Tetracycline promoter mutations decrease non-B DNA structural transitions, negative linking differences and deletions in recombinant plasmids in Escherichia coli.
Journal of molecular biology 1989;207(3):513-26.
1989: F Wohlrab; Robert D Wells
Slight changes in conditions influence the family of non-B-DNA conformations of the herpes simplex virus type 1 DR2 repeats.
The Journal of biological chemistry 1989;264(14):8207-13.
1989: J C Hanvey; M Shimizu; Robert D Wells
Intramolecular DNA triplexes in supercoiled plasmids. II. Effect of base composition and noncentral interruptions on formation and stability.
The Journal of biological chemistry 1989;264(10):5950-6.
1989: M Shimizu; J C Hanvey; Robert D Wells
Intramolecular DNA triplexes in supercoiled plasmids. I. Effect of loop size on formation and stability.
The Journal of biological chemistry 1989;264(10):5944-9.
1988: W Zacharias; M Caserta; T R O'Connor; J E Larson; Robert D Wells
Cytosine methylation as an effector of right-handed to left-handed DNA structural transitions.
Gene 1988;74(1):221-4.
1988: Adam Jaworski; W Zacharias; W T Hsieh; J A Blaho; J E Larson; Robert D Wells
In vivo existence of left-handed DNA.
Gene 1988;74(1):215-20.
1988: Robert D Wells; D A Collier; J C Hanvey; M Shimizu; F Wohlrab
The chemistry and biology of unusual DNA structures adopted by oligopurine.oligopyrimidine sequences.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1988;2(14):2939-49.
1988: J A Blaho; J E Larson; M J McLean; Robert D Wells
Multiple DNA secondary structures in perfect inverted repeat inserts in plasmids. Right-handed B-DNA, cruciforms, and left-handed Z-DNA.
The Journal of biological chemistry 1988;263(28):14446-55.
1988: W Zacharias; Adam Jaworski; J E Larson; Robert D Wells
The B- to Z-DNA equilibrium in vivo is perturbed by biological processes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(19):7069-73.
1988: J C Hanvey; M Shimizu; Robert D Wells
Intramolecular DNA triplexes in supercoiled plasmids.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(17):6292-6.
1988: W C Stevens; D H Huang; Robert D Wells; N R Krishna
1H NMR study of the solution structure of the self-complementary dodecanucleotide d(TGCA)3.
Nucleic acids research 1988;16(14B):7133-43.
1988: J A Thompson; Robert D Wells
HPLC in nucleic acids research.
Nature 1988;334(6177):87-8.
1988: D A Collier; J A Griffin; Robert D Wells
Non-B right-handed DNA conformations of homopurine.homopyrimidine sequences in the murine immunoglobulin C alpha switch region.
The Journal of biological chemistry 1988;263(15):7397-405.
1988: M J McLean; J W Lee; Robert D Wells
Characteristics of Z-DNA helices formed by imperfect (purine-pyrimidine) sequences in plasmids.
The Journal of biological chemistry 1988;263(15):7378-85.
1988: J C Hanvey; J Klysik; Robert D Wells
Influence of DNA sequence on the formation of non-B right-handed helices in oligopurine.oligopyrimidine inserts in plasmids.
The Journal of biological chemistry 1988;263(15):7386-96.
1988: M J McLean; Robert D Wells
The role of DNA sequence in the formation of Z-DNA versus cruciforms in plasmids.
The Journal of biological chemistry 1988;263(15):7370-7.
1988: S Amirhaeri; F Wohlrab; E O Major; Robert D Wells
Unusual DNA structure in the regulatory region of the human papovavirus JC virus.
Journal of virology 1988;62(3):922-31.
1988: Robert D Wells
Unusual DNA structures.
The Journal of biological chemistry 1988;263(3):1095-8.
1987: Adam Jaworski; W T Hsieh; J A Blaho; J E Larson; Robert D Wells
Left-handed DNA in vivo.
Science (New York, N.Y.) 1987;238(4828):773-7.
1987: Peggy A Whitson; W T Hsieh; Robert D Wells; Kathleen S Matthews
Influence of supercoiling and sequence context on operator DNA binding with lac repressor.
The Journal of biological chemistry 1987;262(30):14592-9.
1987: W T Hsieh; Peggy A Whitson; Kathleen S Matthews; Robert D Wells
Influence of sequence and distance between two operators on interaction with the lac repressor.
The Journal of biological chemistry 1987;262(30):14583-91.
1987: W T Hsieh; Robert D Wells
Influence of negative supercoiling and of the proximity of left-handed Z-DNA on the Escherichia coli lactose repressor-operator interaction.
The Journal of biological chemistry 1987;262(30):14576-82.
1987: M J McLean; J E Larson; F Wohlrab; Robert D Wells
Reaction conditions affect the specificity of bromoacetaldehyde as a probe for DNA cruciforms and B-Z junctions.
Nucleic acids research 1987;15(17):6917-35.
1987: H R Bergen; M J Losman; T O'Connor; W Zacharias; J E Larson; M A Accavitti; Robert D Wells; W J Koopman
Specificity of monoclonal anti-Z-DNA antibodies from unimmunized MRL/Mp-lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(3):743-8.
1987: F Wohlrab; M J McLean; Robert D Wells
The segment inversion site of herpes simplex virus type 1 adopts a novel DNA structure.
The Journal of biological chemistry 1987;262(13):6407-16.
1987: Peggy A Whitson; W T Hsieh; Robert D Wells; Kathleen S Matthews
Supercoiling facilitates lac operator-repressor-pseudooperator interactions.
The Journal of biological chemistry 1987;262(11):4943-6.
1987: M Caserta; W Zacharias; D Nwankwo; G G Wilson; Robert D Wells
Cloning, sequencing, in vivo promoter mapping, and expression in Escherichia coli of the gene for the HhaI methyltransferase.
The Journal of biological chemistry 1987;262(10):4770-7.
1987: F Wohlrab; Robert D Wells
Enzymatic probes for left-handed Z-DNA.
Gene amplification and analysis 1987;5():247-56.
1986: M J McLean; J A Blaho; M W Kilpatrick; Robert D Wells
Consecutive A X T pairs can adopt a left-handed DNA structure.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(16):5884-8.
1986: G Galazka; Emil Palecek; Robert D Wells; J Klysik
Site-specific OsO4 modification of the B-Z junctions formed at the (dA-dC)32 region in supercoiled DNA.
The Journal of biological chemistry 1986;261(15):7093-8.
1984: W Zacharias; J E Larson; M W Kilpatrick; Robert D Wells
HhaI methylase and restriction endonuclease as probes for B to Z DNA conformational changes in d(GCGC) sequences.
Nucleic acids research 1984;12(20):7677-92.
1984: J C Marini; P N Effron; T C Goodman; C K Singleton; Robert D Wells; Roger M Wartell; Paul T Englund
Physical characterization of a kinetoplast DNA fragment with unusual properties.
The Journal of biological chemistry 1984;259(14):8974-9.
1984: M W Kilpatrick; J Klysik; C K Singleton; D A Zarling; T M Jovin; Lawrence Hanau; Bernard F Erlanger; Robert D Wells
Intervening sequences in human fetal globin genes adopt left-handed Z helices.
The Journal of biological chemistry 1984;259(11):7268-74.
1984: C K Singleton; M W Kilpatrick; Robert D Wells
S1 nuclease recognizes DNA conformational junctions between left-handed helical (dT-dG n. dC-dA)n and contiguous right-handed sequences.
The Journal of biological chemistry 1984;259(3):1963-7.
1983: T O'Connor; M W Kilpatrick; J Klysik; J E Larson; J C Martin; C K Singleton; S M Stirdivant; W Zacharias; Robert D Wells
Left-handed Z-DNA helices in polymers, restriction fragments, and recombinant plasmids.
Journal of biomolecular structure & dynamics 1983;1(4):999-1009.
1983: Roger M Wartell; J T Harrell; W Zacharias; Robert D Wells
Raman spectroscopy study of the B-Z transition in (dG-dC)n.(dG-dC)n and a DNA restriction fragment.
Journal of biomolecular structure & dynamics 1983;1(1):83-96.
1983: J Klysik; S M Stirdivant; C K Singleton; W Zacharias; Robert D Wells
Effects of 5 cytosine methylation on the B-Z transition in DNA restriction fragments and recombinant plasmids.
Journal of molecular biology 1983;168(1):51-71.
1983: C K Singleton; J Klysik; Robert D Wells
Conformational flexibility of junctions between contiguous B- and Z-DNAs in supercoiled plasmids.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(9):2447-51.
1983: Robert D Wells; R Brennan; K A Chapman; T C Goodman; P A Hart; Wolfgang Hillen; Doug R Kellogg; M W Kilpatrick; R D Klein; J Klysik; P F Lambert; J E Larson; J J Miglietta; S K Neuendorf; T R O'Connor; C K Singleton; S M Stirdivant; C M Veneziale; Roger M Wartell; W Zacharias
Left-handed DNA helices, supercoiling, and the B-Z junction.
Cold Spring Harbor symposia on quantitative biology 1983;47 Pt 1():77-84.
1982: C K Singleton; J Klysik; S M Stirdivant; Robert D Wells
Left-handed Z-DNA is induced by supercoiling in physiological ionic conditions.
Nature 1982;299(5881):312-6.
1982: S M Stirdivant; J Kłysik; Robert D Wells
Energetic and structural inter-relationship between DNA supercoiling and the right- to left-handed Z helix transitions in recombinant plasmids.
The Journal of biological chemistry 1982;257(17):10159-65.
1982: J Kłysik; S M Stirdivant; Robert D Wells
Left-handed DNA. Cloning, characterization, and instability of inserts containing different lengths of (dC-dG) in Escherichia coli.
The Journal of biological chemistry 1982;257(17):10152-8.
1982: Robert D Wells; J J Miglietta; J Kłysik; J E Larson; S M Stirdivant; W Zacharias
Spectroscopic studies on acetylaminofluorene-modified (dT-dG)n . (dC-dA)n suggest a left-handed conformation.
The Journal of biological chemistry 1982;257(17):10166-71.
1982: Roger M Wartell; J Klysik; Wolfgang Hillen; Robert D Wells
Junction between Z and B conformations in a DNA restriction fragment: evaluation by Raman spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(8):2549-53.
1982: W Zacharias; J E Larson; J Klysik; S M Stirdivant; Robert D Wells
Conditions which cause the right-handed to left-handed DNA conformational transitions. Evidence for several types of left-handed DNA structures in solution.
The Journal of biological chemistry 1982;257(6):2775-82.
1981: J Kłysik; S M Stirdivant; J E Larson; P A Hart; Robert D Wells
Left-handed DNA in restriction fragments and a recombinant plasmid.
Nature 1981;290(5808):672-7.
1980: Robert D Wells; T C Goodman; Wolfgang Hillen; Glenn T Horn; R D Klein; J E Larson; U R Müller; S K Neuendorf; N Panayotatos; S M Stirdivant
DNA structure and gene regulation.
Progress in nucleic acid research and molecular biology 1980;24():167-267.
1980: Robert D Wells; Stephen Hardies; Glenn T Horn; B Klein; J E Larson; S K Neuendorf; N Panayotatos; R K Patient; E Selsing
RPC-5 column chromatography for the isolation of DNA fragments.
Methods in enzymology 1980;65(1):327-47.