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Kate Welsh

Research Profile

Chemicals & Drugs

Physiology

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Immunohistochemistry

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Charitha Madiraju; Shu-Ichi Matsuzawa; Tram Ngo; Ian Pass; Michael Cuddy; Paul Diaz; Paulo H Godoi; Eduard A Sergienko; Stefan Vasile; Kate Welsh; John C Reed
TR-FRET-based high-throughput screening assay for identification of UBC13 inhibitors.
Fernando R Pinacho Crisóstomo; Yongmei Feng; Xuejun Zhu; Kate Welsh; Jing An; John C Reed; Ziwei Huang
Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain.
Andreas Krieg; Ricardo G Correa; Jason B Garrison; Gaëlle Le Negrate; Kate Welsh; Ziwei Huang; Wolfram T Knoefel; John C Reed
XIAP mediates NOD signaling via interaction with RIP2.

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All Publications

2012: Charitha Madiraju; Shu-Ichi Matsuzawa; Tram Ngo; Ian Pass; Michael Cuddy; Paul Diaz; Paulo H Godoi; Eduard A Sergienko; Stefan Vasile; Kate Welsh; John C Reed
TR-FRET-based high-throughput screening assay for identification of UBC13 inhibitors.
Journal of biomolecular screening 2012;17(2):163-76.
2009: Fernando R Pinacho Crisóstomo; Yongmei Feng; Xuejun Zhu; Kate Welsh; Jing An; John C Reed; Ziwei Huang
Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain.
Bioorganic & medicinal chemistry letters 2009;19(22):6413-8.
2009: Andreas Krieg; Ricardo G Correa; Jason B Garrison; Gaëlle Le Negrate; Kate Welsh; Ziwei Huang; Wolfram T Knoefel; John C Reed
XIAP mediates NOD signaling via interaction with RIP2.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(34):14524-9.
2008: William H Bisson; Ziming Zhang; Kate Welsh; Jui-Wen Huang; Jennifer Ryan; John C Reed; Maurizio Pellecchia
Binding properties of the C-terminal domain of VIAF.
Chemical biology & drug design 2008;72(5):331-6.
2008: Gaëlle Le Negrate; Benjamin Faustin; Kate Welsh; Markus Loeffler; Maryla Krajewska; Patty Hasegawa; Sohini Mukherjee; Kim Orth; Stan Krajewski; Adam Godzik; Donald G Guiney; John C Reed
Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-kappaB, suppresses IkappaBalpha ubiquitination and modulates innate immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):5045-56.
2008: Saskia A G M Cillessen; John C Reed; Kate Welsh; Clemencia Pinilla; Richard A Houghten; Erik Hooijberg; José Deurhof; Kitty C M Castricum; Pim Kortman; Corine J Hess; Gert Ossenkoppele; Chris J L M Meijer; Joost Oudejans
Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells.
Blood 2008;111(1):369-75.
2006: Temesgen Samuel; Kate Welsh; Thomas Lober; Summanuna H Togo; Juan M Zapata; John C Reed
Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases.
The Journal of biological chemistry 2006;281(2):1080-90.
2005: ShuangDing Wu; Ping Xie; Kate Welsh; Chenglong Li; Chao-Zhou Ni; Xiuwen Zhu; John C Reed; Arnold C Satterthwait; Gail A Bishop; Kathryn R Ely
LMP1 protein from the Epstein-Barr virus is a structural CD40 decoy in B lymphocytes for binding to TRAF3.
The Journal of biological chemistry 2005;280(39):33620-6.
2005: Arnon P Kater; Frank Dicker; Massimo Mangiola; Kate Welsh; Richard A Houghten; John M Ostresh; Adel Nefzi; John C Reed; Clemencia Pinilla; Thomas Kipps
Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis.
Blood 2005;106(5):1742-8.
2005: Maryla Krajewska; Hoguen Kim; Chul Kim; Haeyoun Kang; Kate Welsh; Shu-ichi Matsuzawa; Michelle Tsukamoto; Ronald Thomas; Nuria Assa-Munt; Zhe Piao; Koichi Suzuki; Manuel Perucho; Stan Krajewski; John C Reed
Analysis of apoptosis protein expression in early-stage colorectal cancer suggests opportunities for new prognostic biomarkers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(15):5451-61.
2005: Bing Z Carter; Marcela Gronda; Zhiliang Wang; Kate Welsh; Clemencia Pinilla; Michael Andreeff; Wendy D Schober; Adel Nefzi; Gregory R Pond; Imtiaz A Mawji; Richard A Houghten; John M Ostresh; Joseph Brandwein; Mark D Minden; Andre C Schuh; Richard A Wells; Hans A Messner; Kathy Chun; John C Reed; Aaron D Schimmer
Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells.
Blood 2005;105(10):4043-50.
2005: Temesgen Samuel; Kazuya Okada; Marc L Hyer; Kate Welsh; Juan M Zapata; John C Reed
cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.
Cancer research 2005;65(1):210-8.
2004: Chao-Zhou Ni; Gagik Oganesyan; Kate Welsh; Xiuwen Zhu; John C Reed; Arnold C Satterthwait; Genhong Cheng; Kathryn R Ely
Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7394-400.
2004: Zhiliang Wang; Michael Cuddy; Temesgen Samuel; Kate Welsh; Aaron D Schimmer; Farid Hanaii; Richard A Houghten; Clemencia Pinilla; John C Reed
Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors.
The Journal of biological chemistry 2004;279(46):48168-76.
2004: Takehiko Dohi; Kazuya Okada; Fang Xia; Casey E Wilford; Temesgen Samuel; Kate Welsh; Hiroyuki Marusawa; Hua Zou; Robert Armstrong; Shu-ichi Matsuzawa; Guy S Salvesen; John C Reed; Dario C Altieri
An IAP-IAP complex inhibits apoptosis.
The Journal of biological chemistry 2004;279(33):34087-90.
2004: Jason S Damiano; Vasco Oliveira; Kate Welsh; John C Reed
Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.
The Biochemical journal 2004;381(Pt 1):213-9.
2004: Aaron D Schimmer; Kate Welsh; Clemencia Pinilla; Zhiliang Wang; Maryla Krajewska; Marie-Josee Bonneau; Irene M Pedersen; Shinichi Kitada; Fiona L Scott; Beatrice Bailly-Maitre; Gennadi V Glinsky; Dominic A Scudiero; Edward A Sausville; Guy S Salvesen; Adel Nefzi; John M Ostresh; Richard A Houghten; John C Reed
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.
Cancer cell 2004;5(1):25-35.
2003: Wilfried Roth; Pawel Kermer; Maryla Krajewska; Kate Welsh; S Davis; Stan Krajewski; John C Reed
Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways.
Cell death and differentiation 2003;10(10):1178-87.
2003: Christian Stehlik; Maryla Krajewska; Kate Welsh; Stan Krajewski; Adam Godzik; John C Reed
The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation.
The Biochemical journal 2003;373(Pt 1):101-13.
2003: Hiroyuki Marusawa; Shu-ichi Matsuzawa; Kate Welsh; Hua Zou; Robert Armstrong; Ingo Tamm; John C Reed
HBXIP functions as a cofactor of survivin in apoptosis suppression.
The EMBO journal 2003;22(11):2729-40.
2003: Bin Guo; Dayong Zhai; Edelmira Cabezas; Kate Welsh; Shahrzad Nouraini; Arnold C Satterthwait; John C Reed
Humanin peptide suppresses apoptosis by interfering with Bax activation.
Nature 2003;423(6938):456-61.
2003: Ingo Tamm; Martin Trepel; Marina Cardó-Vila; Yan Sun; Kate Welsh; Edelmira Cabezas; Arnold Swatterthwait; Wadih Arap; John C Reed; Renata Pasqualini
Peptides targeting caspase inhibitors.
The Journal of biological chemistry 2003;278(16):14401-5.
2002: Chao-Zhou Ni; Kate Welsh; Jianhua Zheng; Marnie Havert Fusco; John C Reed; Kathryn R Ely
Crystallization and preliminary X-ray analysis of the TRAF domain of TRAF3.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 8):1340-2.
2001: N Pathan; Hiroyuki Marusawa; Maryla Krajewska; Shu-ichi Matsuzawa; H Kim; K Okada; S Torii; Shinichi Kitada; Stan Krajewski; Kate Welsh; frederic pio; Adam Godzik; John C Reed
TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer.
The Journal of biological chemistry 2001;276(34):32220-9.
2001: Z L Chu; frederic pio; Z Xie; Kate Welsh; Maryla Krajewska; Stan Krajewski; Adam Godzik; John C Reed
A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis.
The Journal of biological chemistry 2001;276(12):9239-45.
2001: E Leo; Quinn Deveraux; Christian Buchholtz; Kate Welsh; Shu-ichi Matsuzawa; Henning Stennicke; Guy S Salvesen; John C Reed
TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis.
The Journal of biological chemistry 2001;276(11):8087-93.
2000: Juan M Zapata; Maryla Krajewska; Stan Krajewski; Shinichi Kitada; Kate Welsh; Anne Monks; N McCloskey; J Gordon; Thomas Kipps; Randy D Gascoyne; Ahmed Shabaik; John C Reed
TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5084-96.
2000: Chao-Zhou Ni; Kate Welsh; E Leo; C K Chiou; H Wu; John C Reed; Kathryn R Ely
Molecular basis for CD40 signaling mediated by TRAF3.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10395-9.
2000: Ingo Tamm; S M Kornblau; Harry Segall; Stan Krajewski; Kate Welsh; Shinichi Kitada; Dominic A Scudiero; G Tudor; Y H Qui; Anne Monks; Michael Andreeff; John C Reed
Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1796-803.
2000: Quinn Deveraux; Kate Welsh; J C Reed
Purification and use of recombinant inhibitor of apoptosis proteins as caspase inhibitors.
Methods in enzymology 2000;322():154-61.
1999: Quinn Deveraux; E Leo; Henning Stennicke; Kate Welsh; Guy S Salvesen; John C Reed
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases.
The EMBO journal 1999;18(19):5242-51.
1999: E Leo; Kate Welsh; Shu-ichi Matsuzawa; Juan M Zapata; Shinichi Kitada; R S Mitchell; Kathryn R Ely; John C Reed
Differential requirements for tumor necrosis factor receptor-associated factor family proteins in CD40-mediated induction of NF-kappaB and Jun N-terminal kinase activation.
The Journal of biological chemistry 1999;274(32):22414-22.
1999: Stan Krajewski; Maryla Krajewska; Lisa M Ellerby; Kate Welsh; Z Xie; Quinn Deveraux; Guy S Salvesen; Dale E Bredesen; Robert E Rosenthal; Gary Fiskum; John C Reed
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5752-7.
1998: R Takahashi; Quinn Deveraux; Ingo Tamm; Kate Welsh; Nuria Assa-Munt; Guy S Salvesen; John C Reed
A single BIR domain of XIAP sufficient for inhibiting caspases.
The Journal of biological chemistry 1998;273(14):7787-90.