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Douglas Brash

Research Profile

Phenomena

Chemicals & Drugs

Disorders

Physiology

Genes & Molecular Sequences

Genes, p53

Living Beings

Mouse

Anatomy

Concepts & Ideas

Molecular Sequence Data

Co-author Network

Publications

TOP 3
Michael Krauthammer; Richard P Lifton; Roger S Lo; Shuangge Ma; Shrikant M Mane; Miguel A Materin; James P McCusker; Deepak Narayan; Joseph Schlessinger; David F Stern; Mario Sznol; Stephan Ariyan; Antonella Bacchiocchi; Titus J Boggon; Marcus W Bosenberg; Douglas E Brash; Ana Capatana; Elaine Cheng; Murim Choi; Matthew J Davis; Ken Dutton-Regester; Perry Evans; Gerald Goh; Byung Hak Ha; Nicholas K Hayward; Edna C Holman; Kenneth K Kidd; Harriet M Kluger; Yong Kong; Ruth Halaban
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Patrick J Rochette; Douglas E Brash
Human telomeres are hypersensitive to UV-induced DNA Damage and refractory to repair.
Patrick J Rochette; Douglas E Brash
Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL.

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All Publications

2012: Michael Krauthammer; Richard P Lifton; Roger S Lo; Shuangge Ma; Shrikant M Mane; Miguel A Materin; James P McCusker; Deepak Narayan; Joseph Schlessinger; David F Stern; Mario Sznol; Stephan Ariyan; Antonella Bacchiocchi; Titus J Boggon; Marcus W Bosenberg; Douglas E Brash; Ana Capatana; Elaine Cheng; Murim Choi; Matthew J Davis; Ken Dutton-Regester; Perry Evans; Gerald Goh; Byung Hak Ha; Nicholas K Hayward; Edna C Holman; Kenneth K Kidd; Harriet M Kluger; Yong Kong; Ruth Halaban
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nature genetics 2012;44(9):1006-14.
2010: Patrick J Rochette; Douglas E Brash
Human telomeres are hypersensitive to UV-induced DNA Damage and refractory to repair.
PLoS genetics 2010;6(4):e1000926.
2008: Patrick J Rochette; Douglas E Brash
Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL.
Mechanisms of ageing and development 2008;129(4):207-14.
2007: Dejan Knezevic; Wengeng Zhang; Patrick J Rochette; Douglas E Brash
Bcl-2 is the target of a UV-inducible apoptosis switch and a node for UV signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(27):11286-91.
2006: Douglas E Brash
Roles of the transcription factor p53 in keratinocyte carcinomas.
The British journal of dermatology 2006;154 Suppl 1():8-10.
2006: Deepak Raj; Douglas E Brash; Douglas Grossman
Keratinocyte apoptosis in epidermal development and disease.
The Journal of investigative dermatology 2006;126(2):243-57.
2005: Anna Asplund; Anna C Gustafsson; Norbert Wikonkál; A Sela; D J Leffell; K Kidd; Joakim Lundeberg; Douglas E Brash; Fredrik Pontén
PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer.
The British journal of dermatology 2005;152(5):868-73.
2005: Douglas E Brash; Wengeng Zhang; Douglas Grossman; Seiji Takeuchi
Colonization of adjacent stem cell compartments by mutant keratinocytes.
Seminars in cancer biology 2005;15(2):97-102.
2005: Wengeng Zhang; Adrianne N Hanks; Kenneth M Boucher; Scott R Florell; Sarah M Allen; April Alexander; Douglas E Brash; Douglas Grossman
UVB-induced apoptosis drives clonal expansion during skin tumor development.
Carcinogenesis 2005;26(1):249-57.
2004: Dejan Knezevic; Douglas E Brash
Role of E2F1 in apoptosis: a case study in feedback loops.
Cell cycle (Georgetown, Tex.) 2004;3(6):729-32.
2003: Eva Remenyik; Norbert Wikonkál; Wengeng Zhang; Vipin Paliwal; Douglas E Brash
Antigen-specific immunity does not mediate acute regression of UVB-induced p53-mutant clones.
Oncogene 2003;22(41):6369-76.
2003: Norbert Wikonkál; Eva Remenyik; Dejan Knezevic; Wengeng Zhang; Ming Liu; Hongyu Zhao; Thomas R Berton; David G Johnson; Douglas E Brash
Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice.
Nature cell biology 2003;5(7):655-60.
2003: Dahai Xue; Hong Shi; James D Smith; Xinguo Chen; Dennis A Noe; Tommy Cedervall; Derek D Yang; Elizabeth Eynon; Douglas E Brash; Michael Kashgarian; Richard A Flavell; Sandra L Wolin
A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7503-8.
2003: Chiquito J Crasto; Thomas M Morse; Michele Migliore; Prakash M Nadkarni; Michael Hines; Douglas E Brash; Perry L Miller; Gordon M Shepherd
Creating knowledgebases to text-mine PUBMED articles using clustering techniques.
AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium 2003;():821.
2002: Douglas E Brash; Pamela A Havre
New careers for antioxidants.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):13969-71.
2002: Pamela A Havre; Sandra O'Reilly; J Justin McCormick; Douglas E Brash
Transformed and tumor-derived human cells exhibit preferential sensitivity to the thiol antioxidants, N-acetyl cysteine and penicillamine.
Cancer research 2002;62(5):1443-9.
2001: Wengeng Zhang; Eva Remenyik; D Zelterman; Douglas E Brash; Norbert Wikonkál
Escaping the stem cell compartment: sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13948-53.
2001: Douglas E Brash; Norbert Wikonkál; Eva Remenyik; Gijsbertus T J van der Horst; E C Friedberg; D L Cheo; Harry van Steeg; Anja Westerman; Henk J van Kranen
The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genes.
The Journal of investigative dermatology 2001;117(5):1234-40.
2001: Douglas Grossman; Paul J Kim; Olivier Blanc-Brude; Douglas E Brash; Simona Tognin; Pier Carlo Marchisio; Dario C Altieri
Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53.
The Journal of clinical investigation 2001;108(7):991-9.
1999: Norbert Wikonkál; Douglas E Brash
Ultraviolet radiation induced signature mutations in photocarcinogenesis.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1999;4(1):6-10.
1999: M Liu; Norbert Wikonkál; Douglas E Brash
Induction of cyclin-dependent kinase inhibitors and G(1) prolongation by the chemopreventive agent N-acetylcysteine.
Carcinogenesis 1999;20(9):1869-72.
1999: M Liu; Norbert Wikonkál; Douglas E Brash
UV induces p21WAF1/CIP1 protein in keratinocytes without p53.
The Journal of investigative dermatology 1999;113(2):283-4.
1998: M Liu; J C Pelling; Jingfang Ju; Edward Chu; Douglas E Brash
Antioxidant action via p53-mediated apoptosis.
Cancer research 1998;58(8):1723-9.
1998: Douglas E Brash; J Pontén
Skin precancer.
Cancer surveys 1998;32():69-113.
1997: Douglas E Brash
Sunlight and the onset of skin cancer.
Trends in genetics : TIG 1997;13(10):410-4.
1996: A S Jonason; S Kunala; G J Price; R J Restifo; H M Spinelli; John A Persing; David J Leffell; R E Tarone; Douglas E Brash
Frequent clones of p53-mutated keratinocytes in normal human skin.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):14025-9.
1996: MR Gailani; Mona Ståhle-Bäckdahl; David J Leffell; M Glynn; Peter G Zaphiropoulos; C Pressman; A B Undén; M Dean; Douglas E Brash; Allen E Bale; R Toftgård
The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas.
Nature genetics 1996;14(1):78-81.
1996: David J Leffell; Douglas E Brash
Sunlight and skin cancer.
Scientific American 1996;275(1):52-3, 56-9.
1996: Douglas E Brash
Cellular proofreading.
Nature medicine 1996;2(5):525-6.
1996: Douglas E Brash; A Ziegler; A S Jonason; J A Simon; S Kunala; David J Leffell
Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1996;1(2):136-42.
1996: A Ziegler; A Jonason; J Simon; David J Leffell; Douglas E Brash
Tumor suppressor gene mutations and photocarcinogenesis.
Photochemistry and photobiology 1996;63(4):432-5.
1996: MR Gailani; David J Leffell; A Ziegler; E G Gross; Douglas E Brash; Allen E Bale
Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma.
Journal of the National Cancer Institute 1996;88(6):349-54.
1995: S Kunala; Douglas E Brash
Intragenic domains of strand-specific repair in Escherichia coli.
Journal of molecular biology 1995;246(2):264-72.
1994: A Ziegler; A S Jonason; David J Leffell; J A Simon; H W Sharma; J Kimmelman; L Remington; Tyler Jacks; Douglas E Brash
Sunburn and p53 in the onset of skin cancer.
Nature 1994;372(6508):773-6.
1993: Bruce G Haffty; Darryl L Carter; Stuart D Flynn; D B Fischer; Douglas E Brash; J Simons; A M Ziegler; James J Fischer
Local recurrence versus new primary: clinical analysis of 82 breast relapses and potential applications for genetic fingerprinting.
International journal of radiation oncology, biology, physics 1993;27(3):575-83.
1992: S Kunala; Douglas E Brash
Excision repair at individual bases of the Escherichia coli lacI gene: relation to mutation hot spots and transcription coupling activity.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):11031-5.
1992: Michael Reiss; Douglas E Brash; T Muñoz-Antonia; J A Simon; A Ziegler; Vincent F Vellucci; Z L Zhou
Status of the p53 tumor suppressor gene in human squamous carcinoma cell lines.
Oncology research 1992;4(8-9):349-57.
1991: Douglas E Brash; J A Rudolph; J A Simon; A Lin; G J McKenna; H P Baden; A J Halperin; J Pontén
A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):10124-8.