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Livio Brasili

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
22
Pigini, Maria
20
Quaglia, Wilma
19
Giannella, Mario
18
Melchiorre, Carlo
14
Angeli, Piero
13
Marucci, Gabriella
12
Giardinà, Dario
10
Bousquet, Pascal
10
Dontenwill, Monique
9
Piergentili, Alessandro
8
Franchini, Silvia
8
Gualtieri, Fulvio
6
Gentili, Francesco
6
Sorbi, Claudia
6
Strappaghetti, Giovannella

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Publications

TOP 3
Brasili Livio; Donati Daniele; Mosti Luisa
The XIXth National Meeting on Medicinal Chemistry: Verona, Italy.
Sorbi Claudia; Franchini Silvia; Tait Annalisa; Prandi Adolfo; Gallesi Rossella; Angeli Piero; Marucci Gabriella; Pirona Lorenza; Poggesi Elena; Brasili Livio
1,3-Dioxolane-based ligands as rigid analogues of naftopidil: structure-affinity/activity relationships at alpha1 and 5-HT1A receptors.
Franchini Silvia; Tait Annalisa; Prandi Adolfo; Sorbi Claudia; Gallesi Rossella; Buccioni Michela; Marucci Gabriella; De Stefani Carla; Cilia Antonio; Brasili Livio
(2,2-Diphenyl-[1,3]oxathiolan-5-ylmethyl)-(3-phenyl-propyl)-amine: a potent and selective 5-HT(1A) receptor agonist.

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All Publications

2009: Brasili Livio; Donati Daniele; Mosti Luisa
The XIXth National Meeting on Medicinal Chemistry: Verona, Italy.
ChemMedChem 2009;4(6):899-904.
2009: Sorbi Claudia; Franchini Silvia; Tait Annalisa; Prandi Adolfo; Gallesi Rossella; Angeli Piero; Marucci Gabriella; Pirona Lorenza; Poggesi Elena; Brasili Livio
1,3-Dioxolane-based ligands as rigid analogues of naftopidil: structure-affinity/activity relationships at alpha1 and 5-HT1A receptors.
ChemMedChem 2009;4(3):393-9.
2009: Franchini Silvia; Tait Annalisa; Prandi Adolfo; Sorbi Claudia; Gallesi Rossella; Buccioni Michela; Marucci Gabriella; De Stefani Carla; Cilia Antonio; Brasili Livio
(2,2-Diphenyl-[1,3]oxathiolan-5-ylmethyl)-(3-phenyl-propyl)-amine: a potent and selective 5-HT(1A) receptor agonist.
ChemMedChem 2009;4(2):196-203.
2005: Tait Annalisa; Luppi Amedeo; Franchini Silvia; Preziosi Elisa; Parenti Carlo; Buccioni Michela; Marucci Gabriella; Leonardi Amedeo; Poggesi Elena; Brasili Livio
1,2,4-Benzothiadiazine derivatives as alpha1 and 5-HT1A receptor ligands.
Bioorganic & medicinal chemistry letters 2005;15(4):1185-8.
2005: Costantino Luca; Gandolfi Francesca; Sorbi Claudia; Franchini Silvia; Prezzavento Orazio; Vittorio Franco; Ronsisvalle Giuseppe; Leonardi Amedeo; Poggesi Elena; Brasili Livio
Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.
Journal of medicinal chemistry 2005;48(1):266-73.
2004: Dupuy L; Urosevic D; Greney H; Quaglia W; Pigini M; Brasili L; Dontenwill M; Bousquet P
I1 imidazoline receptor-mediated effects on apoptotic processes in PC12 cells.
Cell death and differentiation 2004;11(9):1049-52.
2003: Gentili Francesco; Bousquet Pascal; Brasili Livio; Dontenwill Monique; Feldman Josiane; Ghelfi Francesca; Giannella Mario; Piergentili Alessandro; Quaglia Wilma; Pigini Maria
Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues.
Journal of medicinal chemistry 2003;46(11):2169-76.
2003: Brasili Livio; Sorbi Claudia; Franchini Silvia; Manicardi Massimo; Angeli Piero; Marucci Gabriella; Leonardi Amedeo; Poggesi Elena
1,3-dioxolane-based ligands as a novel class of alpha1-adrenoceptor antagonists.
Journal of medicinal chemistry 2003;46(8):1504-11.
2002: Gentili Francesco; Bousquet Pascal; Brasili Livio; Caretto Mariangela; Carrieri Antonio; Dontenwill Monique; Giannella Mario; Marucci Gabriella; Perfumi Marina; Piergentili Alessandro; Quaglia Wilma; Rascente Carla; Pigini Maria
Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole.
Journal of medicinal chemistry 2002;45(1):32-40.
2001: Gulini U; Angeli P; Marucci G; Buccioni M; Giardinà D; Antolini L; Franchini S; Sorbi C; Brasili L
Synthesis, absolute configuration and antimuscarinic activity of the enantiomers of [1-(2,2-diphenyl-[1,3]dioxolan-4-yl)-ethyl]-dimethyl-amine.
Bioorganic & medicinal chemistry letters 2001;11(2):247-50.
2000: Greney H; Ronde P; Magnier C; Maranca F; Rascente C; Quaglia W; Giannella M; Pigini M; Brasili L; Lugnier C; Bousquet P; Dontenwill M
Coupling of I(1) imidazoline receptors to the cAMP pathway: studies with a highly selective ligand, benazoline.
Molecular pharmacology 2000;57(6):1142-51.
2000: Pigini M; Quaglia W; Gentili F; Marucci G; Cantalamessa F; Franchini S; Sorbi C; Brasili L
Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline.
Bioorganic & medicinal chemistry 2000;8(5):883-8.
2000: Brasili L
Enigmatic receptors.
Pharmaceutica acta Helvetiae 2000;74(2-3):201-3.
1999: Quaglia W; Bousquet P; Pigini M; Carotti A; Carrieri A; Dontenwill M; Gentili F; Giannella M; Maranca F; Piergentili A; Brasili L
2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors.
Journal of medicinal chemistry 1999;42(15):2737-40.
1999: Pigini M; Bousquet P; Brasili L; Carrieri A; Dontenwill M; Gentili F; Giannella M; Leonetti F; Piergentili A; Quaglia W; Carotti A
Binding of tracizolines to the imidazoline receptor. Role of lipophilicity in quantitative structure-activity relationship models.
Annals of the New York Academy of Sciences 1999;881():118-22.
1999: Bruban V; Feldman J; Dontenwill M; Greney H; Brasili L; Giannella M; Pigini M; Bousquet P
An unexpected central hypertensive effect of the new imidazoline compound benazoline.
Annals of the New York Academy of Sciences 1999;881():102-5.
1998: Pigini M; Bousquet P; Brasili L; Carrieri A; Cavagna R; Dontenwill M; Gentili F; Giannella M; Leonetti F; Piergentili A; Quaglia W; Carotti A
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models.
Bioorganic & medicinal chemistry 1998;6(12):2245-60.
1998: Malmusi L; Franchini S; Mucci A; Schenetti L; Gulini U; Marucci G; Brasili L
Synthesis and antimuscarinic activity of some ether- and thioether-bearing 1,3-dioxolanes and related sulfoxides and sulfones.
Bioorganic & medicinal chemistry 1998;6(6):825-32.
1998: Quaglia W; Giannella M; Piergentili A; Pigini M; Brasili L; Di Toro R; Rossetti L; Spampinato S; Melchiorre C
1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand.
Journal of medicinal chemistry 1998;41(10):1557-60.
1997: Carrieri A; Brasili L; Leonetti F; Pigini M; Giannella M; Bousquet P; Carotti A
2-D and 3-D modeling of imidazoline receptor ligands: insights into pharmacophore.
Bioorganic & medicinal chemistry 1997;5(5):843-56.
1997: Pigini M; Bousquet P; Carotti A; Dontenwill M; Giannella M; Moriconi R; Piergentili A; Quaglia W; Tayebati S K; Brasili L
Imidazoline receptors: qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity.
Bioorganic & medicinal chemistry 1997;5(5):833-41.
1997: Angeli P; Brasili L; Cingolani M L; Marucci G; Piergentili A; Pigini M; Quaglia W
Synthesis and structure-activity relationship studies in a series of 2-substituted 1,3-dioxolanes modified at the cationic head.
Bioorganic & medicinal chemistry 1997;5(4):731-7.
1996: Malmusi L; Mucci A; Schenetti L; Gulini U; Marucci G; Brasili L
Synthesis, NMR spectroscopy study, and antimuscarinic activity of a series of 2-(acyloxymethyl)-1,3-dioxolanes.
Bioorganic & medicinal chemistry 1996;4(12):2071-80.
1995: Brasili L; Pigini M; Marucci G; Quaglia W; Malmusi L; Lanier S M; Lanier B
Separation of alpha-adrenergic and imidazoline/guanidinium receptive sites (IGRS) activity in a series of imidazoline analogues of cirazoline.
Bioorganic & medicinal chemistry 1995;3(11):1503-9.
1995: Brasili L; Pigini M; Ehrhardt J D; Molines A; Greney H; Bousquet P; Dontenwill M
Structure-affinity relationship of cirazoline derivatives for idazoxan imidazoline-specific sites in the human cerebral cortex and the rabbit kidney.
Annals of the New York Academy of Sciences 1995;763():149-52.
1994: Piergentili A; Quaglia W; Tayebati S K; Paparelli F; Malmusi L; Brasili L
Synthesis and muscarinic receptors affinity of a series of antagonist bivalent ligands.
Farmaco (Società chimica italiana : 1989) 1994;49(2):83-7.
1991: Angeli P; Brasili L; Cingolani M L; Marucci G; Pigini P; Tonnini M C
Pharmacological characterization of muscarinic receptor subtypes in rabbit isolated tissue preparations.
Journal of autonomic pharmacology 1991;11(5):315-21.
1990: Angeli P; Brasili L; Cantalamessa F; Marucci G; Wess J
Determination of muscarinic agonist potencies at M1 and M2 muscarinic receptors in a modified pithed rat preparation.
Naunyn-Schmiedeberg's archives of pharmacology 1990;342(6):625-9.
1989: Corsano S; Strappaghetti G; Di Domenico E; Brasili L; Picchio M T
Synthesis and Ca-antagonist activity of some benzhydryl derivatives.
Archiv der Pharmazie 1989;322(12):873-8.
1989: Melchiorre C; Quaglia W; Picchio M T; Giardinà D; Brasili L; Angeli P
Structure-activity relationships among methoctramine-related polymethylene tetraamines. Chain-length and substituent effects on M-2 muscarinic receptor blocking activity.
Journal of medicinal chemistry 1989;32(1):79-84.
1989: Giardinà D; Brasili L; Gregori M; Massi M; Picchio M T; Quaglia W; Melchiorre C
Structure-activity relationships in prazosin-related compounds. Effect of replacing a piperazine ring with an alkanediamine moiety on alpha 1-adrenoreceptor blocking activity.
Journal of medicinal chemistry 1989;32(1):50-5.
1988: Pigini M; Brasili L; Giannella M; Giardinà D; Gulini U; Quaglia W; Melchiorre C
Structure-activity relationships in 1,4-benzodioxan-related compounds. Investigation on the role of the dehydrodioxane ring on alpha 1-adrenoreceptor blocking activity.
Journal of medicinal chemistry 1988;31(12):2300-4.
1988: Romanelli M N; Gualtieri F; Valle G; Brasili L; Angeli P
Enantioselectivity of muscarinic antagonists. Isomeric 2-cyclohexyl-2-phenyl-5-[(dimethylamino)methyl]-1,3-oxathiolane methiodides.
Journal of medicinal chemistry 1988;31(9):1703-8.
1988: Romanelli M N; Teodori E; Gualtieri F; Angeli P; Brasili L
Enantioselectivity of muscarinic antagonists. 2,2-Dicyclohexyl-5-[(dimethylamino)methyl]-1,3-oxathiolane methiodides and related 3-oxides.
Journal of medicinal chemistry 1988;31(9):1698-702.
1988: Quaglia W; Brasili L; Cristalli G; Giardinà D; Picchio M T; Melchiorre C
Structure-activity relationships among benextramine-related tetraamine disulfides. Chain length effect on alpha-adrenoreceptor blocking activity.
Journal of medicinal chemistry 1988;31(9):1861-6.
1988: Melchiorre C; Cassinelli A; Brasili L; Giardinà D; Gulini U; Quaglia W
Alpha-adrenoceptor occupancy by N,N-dimethyl-2-bromo-2-phenethylamine hydrobromide (DMPEA) in rat vas deferens.
European journal of pharmacology 1988;153(2-3):255-61.
1988: Angeli P; Brasili L; Giannella M; Gualtieri F; Picchio M T; Teodori E
Chiral muscarinic agonists possessing a 1,3-oxathiolane nucleus: enantio- and tissue-selectivity on isolated preparations of guinea-pig ileum and atria and of rat urinary bladder.
Naunyn-Schmiedeberg's archives of pharmacology 1988;337(3):241-5.
1988: Corsano S; Strappaghetti G; Brasili L
Synthesis and pharmacological evaluation of some analogues of the Ca-antagonist cinnarizine.
Archiv der Pharmazie 1988;321(3):171-4.
1987: Brasili L; Cantalamessa F; Picchio M T; Quaglia W
Fluoronorepinephrines: further pharmacological evaluation in vitro and in pithed rats.
European journal of pharmacology 1987;144(2):141-6.
1987: Teodori E; Gualtieri F; Angeli P; Brasili L; Giannella M
Resolution, absolute configuration, and cholinergic enantioselectivity of (-)- and (+)-c-2-methyl-r-5-[(dimethylamino)methyl]-1,3-oxathiolane t-3-oxide methiodide and related sulfones.
Journal of medicinal chemistry 1987;30(10):1934-8.
1986: Strappaghetti G; Brasili L
Synthesis and pharmacological evaluation of cyclic and opened thioanalogues of piperoxan.
Il Farmaco; edizione scientifica 1986;41(10):794-800.
1986: Teodori E; Gualtieri F; Angeli P; Brasili L; Giannella M; Pigini M
Resolution, absolute configuration, and cholinergic enantioselectivity of (+)- and (-)-cis-2-methyl-5-[(dimethylamino)methyl]-1,3-oxathiolane methiodide.
Journal of medicinal chemistry 1986;29(9):1610-5.
1986: Massi M; Venturi F; Brasili L; Melchiorre C
Hypotensive effect in dogs and rats of intravenous injections of the alpha 1-adrenoreceptor antagonist benoxathian.
Pharmacological research communications 1986;18(9):813-29.
1986: Brasili L; Cassinelli A; Angeli P; Melchiorre C
Thiol group may be involved in the irreversible blockade of presynaptic alpha 2-adrenoreceptors by pyrextramine and benextramine in the isolated guinea pig ileum.
Life sciences 1986;38(18):1633-40.
1985: Angeli P; Brasili L; Brancia E; Giardinà D; Quaglia W; Melchiorre C
Structure-activity relationships among benextramine-related tetraamine disulfides at peripheral alpha-adrenoreceptors.
Journal of medicinal chemistry 1985;28(11):1643-7.
1985: Giardinà D; Bertini R; Brancia E; Brasili L; Melchiorre C
Structure-activity relationships for prazosin and WB 4101 analogues as alpha 1-adrenoreceptor antagonists.
Journal of medicinal chemistry 1985;28(9):1354-7.
1985: Angeli P; Brasili L; Giannella M; Gualtieri F; Pigini M
Affinity and efficacy correlate with chemical structure more than potency does in a series of pentatomic cyclic muscarinic agonists.
British journal of pharmacology 1985;85(4):783-6.
1984: Melchiorre C; Brasili L; Giardinà D; Pigini M; Strappaghetti G
2-[[[2-(2,6-Dimethoxyphenoxy)ethyl]amino]-methyl] -1,4-benzoxathian: a new antagonist with high potency and selectivity toward alpha 1-adrenoreceptors.
Journal of medicinal chemistry 1984;27(12):1535-6.
1984: Brasili L; Angeli P; Brancia E; Melchiorre C
N,N''-(dithio-2,1-ethanediyl)bis[N'-(pyrrol-2-ylmethyl)-1, 6,- hexanediamine] (pyrextramine), a new irreversible alpha 1-adrenoreceptor blocking agent of the tetramine disulfide class.
European journal of pharmacology 1984;103(1-2):181-4.
1984: Castagnino E; Strappaghetti G; Corsano S; Gallucci P; Brasili L; Giardinà D
Synthesis and pharmacological evaluation of some WB4101 analogues bearing a naphthodioxanic nucleus.
Il Farmaco; edizione scientifica 1984;39(7):569-74.
1983: Castagnino E; Corsano S; Strappaghetti G; Brasili L; Gallucci P
Synthesis and pharmacological evaluation of propranolol-cyclic analogues.
Il Farmaco; edizione scientifica 1983;38(9):679-85.
1982: Melchiorre C; Giardinà D; Gallucci P; Brasili L
Structural requirements for competitive alpha-adrenoceptor occupancy by cyclic and opened analogues of WB 4101.
The Journal of pharmacy and pharmacology 1982;34(10):683-4.
1982: Gualtieri F; Brasili L; Giannella M; Pigini M
Molecular requirements of the active sites of the cholinergic receptors. XIX-Size evaluation of the muscarinic subsite.
Il Farmaco; edizione scientifica 1982;37(9):618-26.
1982: Brasili L; Leonelli M; Giannella M
Molecular requirements of the active sites of the cholinergic receptors. XVIII-Correlation between activity and double bond position among cyclopentene derivatives.
Il Farmaco; edizione scientifica 1982;37(7):431-7.
1981: Angeli P; Brasili L; Giardinà D; Melchiorre C
Molecular requirements of the active site of cholinergic receptors XV: Synthesis and biological activity of 2,3-dehydrodeoxamuscarone and 2,3-dehydrodeoxamuscarines.
Journal of pharmaceutical sciences 1981;70(5):489-92.
1981: Pigini M; Brasili L
Molecular requirements of the active sites of the cholinergic receptors. XVI - Synthesis and cholinergic activity of 2- or 5-alkyl or 5-phenyl-4-methyl-3-oxo-1-dimethylaminomethylcyclopentane methiodide.
Il Farmaco; edizione scientifica 1981;36(2):152-8.
1980: Brasili L; Melchiorre C; Belleau B; Benfey B G
Reactivation by cysteamine of vascular alpha adrenoceptors blocked by the tetramine disulfide benextramine and interaction of benextramine with phenoxybenzamine.
Canadian journal of physiology and pharmacology 1980;58(12):1490-3.
1980: Benfey B G; Belleau B; Brasili L; Giannella M; Melchiorre C
Irreversible alpha adrenoceptor blocking effects and reversible muscarinic blocking and nicotinic blocking effects of tetramine disulfides on the heart.
Canadian journal of physiology and pharmacology 1980;58(12):1477-83.
1980: Benfey B G; Brasili L; Melchiorre C; Belleau B
Potentiation and inhibition of nicotinic effects on striated muscle by the tetramine disulfide benextramine.
Canadian journal of physiology and pharmacology 1980;58(8):984-8.
1980: Giannella M; Angeli P; Melchiorre C; Brasili L
Molecular requirements of the active sites of the cholinergic receptors. XII - 3-Methyl-2-oxo-1-dimethylaminomethylcyclopentane methiodide as a new selective agonist for the nicotinic receptor.
Il Farmaco; edizione scientifica 1980;35(4):253-62.
1980: Pigini M; Ballini R; Gualtieri F; Brasili L
Molecular requirements of the active sites of the cholinergic receptors. XI - Synthesis and biological evaluation of isomuscarie and its isomers.
Il Farmaco; edizione scientifica 1980;35(3):167-80.

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