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Jesper Wengel

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Pedro M D Moreno; Iulian I Oprea; Y Vladimir Pabon; Erik B Pedersen; Cristina S J Rocha; Samir El-Andaloussi; Helen Bergquist; Burcu Bestas; Sylvain Geny; Per T Jørgensen; Karin E Lundin; Jesper Wengel; Eman M Zaghloul; Rula Zain; C I Edvard Smith
Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA.
I Kira Astakhova; Meghan A Campbell; Pankaj Gupta; Karol Pasternak; Jesper Wengel
A locked nucleic acid-based nanocrawler: designed and reversible movement detected by multicolor fluorescence.
Allan G Hansen; Kasper K Karlsen; Richard J Nichols; Princia Salvatore; Jesper Wengel; Jens Ulstrup
Electrochemistry and in situ scanning tunnelling microscopy of pure and redox-marked DNA- and UNA-based oligonucleotides on Au(111)-electrode surfaces.

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All Publications

2013: Pedro M D Moreno; Iulian I Oprea; Y Vladimir Pabon; Erik B Pedersen; Cristina S J Rocha; Samir El-Andaloussi; Helen Bergquist; Burcu Bestas; Sylvain Geny; Per T Jørgensen; Karin E Lundin; Jesper Wengel; Eman M Zaghloul; Rula Zain; C I Edvard Smith
Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA.
Nucleic acids research 2013;41(5):3257-73.
2013: I Kira Astakhova; Meghan A Campbell; Pankaj Gupta; Karol Pasternak; Jesper Wengel
A locked nucleic acid-based nanocrawler: designed and reversible movement detected by multicolor fluorescence.
Journal of the American Chemical Society 2013;135(7):2423-6.
2013: Allan G Hansen; Kasper K Karlsen; Richard J Nichols; Princia Salvatore; Jesper Wengel; Jens Ulstrup
Electrochemistry and in situ scanning tunnelling microscopy of pure and redox-marked DNA- and UNA-based oligonucleotides on Au(111)-electrode surfaces.
Physical chemistry chemical physics : PCCP 2013;15(3):776-86.
2013: I Kira Astakhova; Meghan A Campbell; Vladimir A Korshun; Alexey V Ustinov; T Santhosh Kumar; Jesper Wengel
Branched DNA nanostructures efficiently stabilised and monitored by novel pyrene-perylene 2'-α-L-amino-LNA FRET pairs.
Chemical communications (Cambridge, England) 2013;49(5):511-3.
2013: I Kira Astakhova; Jesper Wengel
Interfacing click chemistry with automated oligonucleotide synthesis for the preparation of fluorescent DNA probes containing internal xanthene and cyanine dyes.
Chemistry (Weinheim an der Bergstrasse, Germany) 2013;19(3):1112-22.
2012: Andreas Stahl Madsen; Troels Bundgaard Jensen; Anna Søndergaard Jørgensen; Jesper Wengel
Large scale synthesis of 2'-amino-LNA thymine and 5-methylcytosine nucleosides.
The Journal of organic chemistry 2012;77(23):10718-28.
2012: Kasper K Karlsen; Jesper Wengel
Locked nucleic acid and aptamers.
Nucleic acid therapeutics 2012;22(6):366-70.
2012: Ulrike Wenge; Jesper Wengel; Hans-Achim Wagenknecht
Photoinduced reductive electron transfer in LNA:DNA hybrids: a compromise between conformation and base stacking.
Angewandte Chemie (International ed. in English) 2012;51(40):10026-9.
2012: Lucile Crouzier; Camille Dubois; Jesper Wengel; Rakesh N Veedu
Cleavage and protection of locked nucleic acid-modified DNA by restriction endonucleases.
Bioorganic & medicinal chemistry letters 2012;22(14):4836-8.
2012: Irina Kira Astakhova; B Ravindra Babu; Evgeniya Samokhina; Jesper Wengel
Novel (phenylethynyl)pyrene-LNA constructs for fluorescence SNP sensing in polymorphic nucleic acid targets.
Chembiochem : a European journal of chemical biology 2012;13(10):1509-19.
2012: Camille Dubois; Stacey L Edwards; Meghan A Campbell; Jesper Wengel; Rakesh N Veedu
Stepping towards highly flexible aptamers: enzymatic recognition studies of unlocked nucleic acid nucleotides.
Chemical communications (Cambridge, England) 2012;48(44):5503-5.
2012: Marie W Johannsen; Andreas Stahl Madsen; Rakesh N Veedu; Jesper Wengel
Enzymatic polymerisation involving 2'-amino-LNA nucleotides.
Bioorganic & medicinal chemistry letters 2012;22(10):3522-6.
2012: Brian Dall Schyth; Jesper Wengel; Malgorzata Maria Pakula; Jesper Bertram Bramsen; Jørgen Kjems; Sekar Larashati; Niels Lorenzen
In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important.
Nucleic acids research 2012;40(10):4653-65.
2012: Vitor B Pinheiro; Marleen Renders; Alexander I Taylor; Jesper Wengel; Su Zhang; Mikhail Abramov; John C Chaput; Christopher Cozens; Piet Herdewijn; Stephen H McLaughlin; Sew-Yeu Peak Chew; Philipp Holliger
Synthetic genetic polymers capable of heredity and evolution.
Science (New York, N.Y.) 2012;336(6079):341-4.
2012: Andreas S Madsen; Jesper Wengel
Oligonucleotides with 1,4-dioxane-based nucleotide monomers.
The Journal of organic chemistry 2012;77(8):3878-86.
2012: Kasper K Karlsen; Anna Pasternak; Troels B Jensen; Jesper Wengel
Pyrene-modified unlocked nucleic acids: synthesis, thermodynamic studies, and fluorescent properties.
Chembiochem : a European journal of chemical biology 2012;13(4):590-601.
2012: Sunil K Singh; Smriti Srivastava; Jesper Wengel; L Chandrashekhar Reddy; Yogesh S Sanghvi; Niels Langkjær; Carl E Olsen; Virinder S Parmar; Ashok K Prasad
Selective biocatalytic acylation studies on 5'-O-(4,4'-dimethoxytrityl)-2',3'-secouridine: an efficient synthesis of UNA monomer.
Nucleosides, nucleotides & nucleic acids 2012;31(12):831-40.
2012: Holger Doessing; Lykke H Hansen; Rakesh N Veedu; Jesper Wengel; Birte Vester
Amplification and re-generation of LNA-modified libraries.
Molecules (Basel, Switzerland) 2012;17(11):13087-97.
2012: Torben Højland; Rakesh N Veedu; Birte Vester; Jesper Wengel
Enzymatic synthesis of DNA strands containing α-L-LNA (α-L-configured locked nucleic acid) thymine nucleotides.
Artificial DNA, PNA & XNA 2012;3(1):14-21.
2012: Lucile Crouzier; Camille Dubois; Stacey L Edwards; Lasse H Lauridsen; Jesper Wengel; Rakesh N Veedu
Efficient reverse transcription using locked nucleic acid nucleotides towards the evolution of nuclease resistant RNA aptamers.
PloS one 2012;7(4):e35990.
2012: Andrés Muñoz-Alarcón; Cristian Romero; Jesper Wengel; Kim A Lennox; Mark A Behlke; Samir El-Andaloussi; Peter Guterstam; Ulo Langel
Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization.
ISRN pharmaceutics 2012;2012():407154.
2011: Karol Pasternak; Rakesh N Veedu; Pankaj Gupta; Anna Pasternak; Jesper Wengel
Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2'-amino-LNA monomers.
Bioorganic & medicinal chemistry 2011;19(24):7407-15.
2011: Meghan A Campbell; Jesper Wengel
Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals.
Chemical Society reviews 2011;40(12):5680-9.
2011: Troels Bundgaard Jensen; Anna Pasternak; Michael Petersen; Andreas Stahl Madsen; Jesper Wengel
Synthesis and structural characterization of 2'-fluoro-α-L-RNA-modified oligonucleotides.
Chembiochem : a European journal of chemical biology 2011;12(12):1904-11.
2011: Troels B Jensen; Thomas L Andresen; Jonas R Henriksen; Bjarne E Rasmussen; Lars M Rasmussen; Jesper Wengel; Anna Pasternak
Thermodynamic and biological evaluation of a thrombin binding aptamer modified with several unlocked nucleic acid (UNA) monomers and a 2'-C-piperazino-UNA monomer.
Bioorganic & medicinal chemistry 2011;19(16):4739-45.
2011: Anna Pasternak; Jesper Wengel
Unlocked nucleic acid--an RNA modification with broad potential.
Organic & biomolecular chemistry 2011;9(10):3591-7.
2011: Irina V Astakhova; Alexey V Ustinov; Vladimir A Korshun; Jesper Wengel
LNA for optimization of fluorescent oligonucleotide probes: improved spectral properties and target binding.
Bioconjugate chemistry 2011;22(4):533-9.
2011: Joan Skov; Torsten Bryld; Dorthe Lindegaard; Katrine E Nielsen; Torben Højland; Jesper Wengel; Michael Petersen
Synthesis and structural characterization of piperazino-modified DNA that favours hybridization towards DNA over RNA.
Nucleic acids research 2011;39(5):1953-65.
2011: Anna Pasternak; Frank J Hernandez; Lars M Rasmussen; Birte Vester; Jesper Wengel
Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer.
Nucleic acids research 2011;39(3):1155-64.
2011: Eman M Zaghloul; Andreas S Madsen; Pedro M D Moreno; Iulian I Oprea; Samir El-Andaloussi; Burcu Bestas; Pankaj Gupta; Erik B Pedersen; Karin E Lundin; Jesper Wengel; C I Edvard Smith
Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA.
Nucleic acids research 2011;39(3):1142-54.
2011: Anna Pasternak; Jesper Wengel
Modulation of i-motif thermodynamic stability by the introduction of UNA (unlocked nucleic acid) monomers.
Bioorganic & medicinal chemistry letters 2011;21(2):752-5.
2011: Marie W Johannsen; Lia Crispino; Michael C Wamberg; Neerja Kalra; Jesper Wengel
Amino acids attached to 2'-amino-LNA: synthesis and excellent duplex stability.
Organic & biomolecular chemistry 2011;9(1):243-52.
2010: Michael E Østergaard; Jyotirmoy Maity; B Ravindra Babu; Jesper Wengel; Patrick J Hrdlicka
Novel insights into the use of Glowing LNA as nucleic acid detection probes--influence of labeling density and nucleobases.
Bioorganic & medicinal chemistry letters 2010;20(24):7265-8.
2010: Irina V Astakhova; Dorthe Lindegaard; Vladimir A Korshun; Jesper Wengel
Novel interstrand communication systems within DNA duplexes based on 1-, 2- and 4-(phenylethynyl)pyrenes attached to 2'-amino-LNA: high-affinity hybridization and fluorescence sensing.
Chemical communications (Cambridge, England) 2010;46(44):8362-4.
2010: Rakesh N Veedu; Harsha V Burri; Pawan Kumar; Pawan K Sharma; Patrick J Hrdlicka; Birte Vester; Jesper Wengel
Polymerase-directed synthesis of C5-ethynyl locked nucleic acids.
Bioorganic & medicinal chemistry letters 2010;20(22):6565-8.
2010: Andreas Madsen; T Santhosh Kumar; Jesper Wengel
LNA 5'-phosphoramidites for 5'→3'-oligonucleotide synthesis.
Organic & biomolecular chemistry 2010;8(21):5012-6.
2010: Anna Pasternak; Jesper Wengel
Thermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides.
Nucleic acids research 2010;38(19):6697-706.
2010: Jesper B Bramsen; Malgorzata M Pakula; Thomas B Hansen; Claus Bus; Niels Langkjær; Dalibor Odadzic; Romualdas Smicius; Suzy L Wengel; Jyoti Chattopadhyaya; Joachim W Engels; Piet Herdewijn; Jesper Wengel; Jørgen Kjems
A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.
Nucleic acids research 2010;38(17):5761-73.
2010: Jan Mollenhauer; Dimitrios Stamou; Allan Flyvbjerg; Jesper Wengel; Ulrik Gether; Jørgen Kjems; Thomas Bjørnholm; Flemming Besenbacher
David versus Goliath.
Nanomedicine : nanotechnology, biology, and medicine 2010;6(4):504-9.
2010: Maria B Laursen; Malgorzata M Pakula; Shan Gao; Kees Fluiter; Olaf R Mook; Frank Baas; Niels Langklaer; Suzy L Wengel; Jesper Wengel; Jørgen Kjems; Jesper B Bramsen
Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo.
Molecular bioSystems 2010;6(5):862-70.
2010: Rakesh N Veedu; Jesper Wengel
Locked nucleic acids: promising nucleic acid analogs for therapeutic applications.
Chemistry & biodiversity 2010;7(3):536-42.
2010: Denise Werk; Jesper Wengel; Suzy L Wengel; Hans-Peter Grunert; Heinz Zeichhardt; Jens Kurreck
Application of small interfering RNAs modified by unlocked nucleic acid (UNA) to inhibit the heart-pathogenic coxsackievirus B3.
FEBS letters 2010;584(3):591-8.
2010: Andrzej Gondela; Thatikonda Santhosh Kumar; Krzysztof Walczak; Jesper Wengel
Synthesis and biophysical properties of oligodeoxynucleotides containing 2'-deoxy-5-(4-nitro-1H-imidazol-1-yl)-beta-D-uridine and 2'-deoxy-5-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-beta-D-uridine monomers.
Chemistry & biodiversity 2010;7(2):350-62.
2009: Frank J Hernandez; Neerja Kalra; Jesper Wengel; Birte Vester
Aptamers as a model for functional evaluation of LNA and 2'-amino LNA.
Bioorganic & medicinal chemistry letters 2009;19(23):6585-7.
2009: Kasper K Karlsen; Troels B Jensen; Jesper Wengel
Synthesis of an unlocked nucleic acid terpyridine monomer and binding of divalent metal ion in nucleic acid duplexes.
The Journal of organic chemistry 2009;74(22):8838-41.
2009: Niels Langkjaer; Anna Pasternak; Jesper Wengel
UNA (unlocked nucleic acid): a flexible RNA mimic that allows engineering of nucleic acid duplex stability.
Bioorganic & medicinal chemistry 2009;17(15):5420-5.
2009: Kees Fluiter; Olaf R F Mook; Jeroen Vreijling; Niels Langkjaer; Torben Højland; Jesper Wengel; Frank Baas
Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4'-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer.
Molecular bioSystems 2009;5(8):838-43.
2009: Rakesh N Veedu; Jesper Wengel
Locked nucleic acid nucleoside triphosphates and polymerases: on the way towards evolution of LNA aptamers.
Molecular bioSystems 2009;5(8):787-92.
2009: Rakesh N Veedu; Jesper Wengel
Locked nucleic acid as a novel class of therapeutic agents.
RNA biology 2009;6(3):321-3.
2009: Shan Gao; Frederik Dagnaes-Hansen; Ebbe Juel Bech Nielsen; Jesper Wengel; Flemming Besenbacher; Kenneth A Howard; Jørgen Kjems
The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(7):1225-33.
2009: Pankaj Gupta; Jyotirmoy Maity; Gaurav Shakya; Ashok K Prasad; Virinder S Parmar; Jesper Wengel
Synthesis and hybridization studies of alpha-configured arabino nucleic acids.
Organic & biomolecular chemistry 2009;7(11):2389-401.
2009: Sys Zoffmann Glud; Jesper B Bramsen; Frederik Dagnaes-Hansen; Jesper Wengel; Kenneth Alan Howard; Jens R Nyengaard; Jørgen Kjems
Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration.
Oligonucleotides 2009;19(2):163-8.
2009: Koji Nagahama; Rakesh N Veedu; Jesper Wengel
Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides.
Bioorganic & medicinal chemistry letters 2009;19(10):2707-9.
2009: Tadashi Umemoto; Jesper Wengel; Andreas Madsen
Functionalization of 2'-amino-LNA with additional nucleobases.
Organic & biomolecular chemistry 2009;7(9):1793-7.
2009: T Santhosh Kumar; Michael E Ostergaard; Pawan K Sharma; Poul Nielsen; Jesper Wengel; Patrick J Hrdlicka
Parallel RNA-strand recognition by 2'-amino-beta-L-LNA.
Bioorganic & medicinal chemistry letters 2009;19(9):2396-9.
2009: Rakesh N Veedu; Birte Vester; Jesper Wengel
Efficient enzymatic synthesis of LNA-modified DNA duplexes using KOD DNA polymerase.
Organic & biomolecular chemistry 2009;7(7):1404-9.
2009: T Santhosh Kumar; Andreas Madsen; Michael E Østergaard; Sujay P Sau; Jesper Wengel; Patrick J Hrdlicka
Functionalized 2'-amino-alpha-L-LNA: directed positioning of intercalators for DNA targeting.
The Journal of organic chemistry 2009;74(3):1070-81.
2008: Irina V Astakhova; Vladimir A Korshun; Kasper Jahn; Jørgen Kjems; Jesper Wengel
Perylene attached to 2'-amino-LNA: synthesis, incorporation into oligonucleotides, and remarkable fluorescence properties in vitro and in cell culture.
Bioconjugate chemistry 2008;19(10):1995-2007.
2008: T Santhosh Kumar; Andreas Madsen; Michael E Østergaard; Jesper Wengel; Patrick J Hrdlicka
Nucleic acid structural engineering using pyrene-functionalized 2'-amino-alpha-L-LNA monomers and abasic sites.
The Journal of organic chemistry 2008;73(18):7060-6.
2008: Mariola Dutkiewicz; Hans-Peter Grunert; Heinz Zeichhardt; Suzy W Lena; Jesper Wengel; Jens Kurreck
Design of LNA-modified siRNAs against the highly structured 5' UTR of coxsackievirus B3.
FEBS letters 2008;582(20):3061-6.
2008: Rakesh N Veedu; Birte Vester; Jesper Wengel
Polymerase chain reaction and transcription using locked nucleic acid nucleotide triphosphates.
Journal of the American Chemical Society 2008;130(26):8124-5.
2008: Peter Guterstam; Maria Lindgren; Henrik Johansson; Ulf Tedebark; Jesper Wengel; Samir El-Andaloussi; Ulo Langel
Splice-switching efficiency and specificity for oligonucleotides with locked nucleic acid monomers.
The Biochemical journal 2008;412(2):307-13.
2008: Birte Vester; Anne Marie Boel; Sune Lobedanz; B Ravindra Babu; Michael Raunkjaer; Dorthe Lindegaard; Patrick J Hrdlicka; Torben Højland; Pawan K Sharma; Surender Kumar; Poul Nielsen; Jesper Wengel
Chemically modified oligonucleotides with efficient RNase H response.
Bioorganic & medicinal chemistry letters 2008;18(7):2296-300.
2008: Marcin Kalek; Peter Benediktson; Birte Vester; Jesper Wengel
Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach.
Chemical communications (Cambridge, England) 2008;(6):762-4.
2008: Harleen Kaur; Jesper Wengel; Souvik Maiti
Thermodynamics of DNA-RNA heteroduplex formation: effects of locked nucleic acid nucleotides incorporated into the DNA strand.
Biochemistry 2008;47(4):1218-27.
2008: Céline Desnous; B Ravindra Babu; Céline Moriou; Javier Ulises Ortiz Mayo; Alain Favre; Jesper Wengel; Pascale Clivio
The sugar conformation governs (6-4) photoproduct formation at the dinucleotide level.
Journal of the American Chemical Society 2008;130(1):30-1.
2008: Irina V Astakhova; Vladimir A Korshun; Jesper Wengel
Highly fluorescent conjugated pyrenes in nucleic acid probes: (phenylethynyl)pyrenecarbonyl-functionalized locked nucleic acids.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(35):11010-26.
2008: Harleen Kaur; Amit Arora; Jesper Wengel; Souvik Maiti
Thermodynamic, counterion and hydration effects for the incorporation of locked nucleic acid (LNA) nucleotides in duplex.
Nucleic acids symposium series (2004) 2008;(52):425-6.
2008: Amit Arora; Harleen Kaur; Jesper Wengel; Souvik Maiti
Effect of locked nucleic acid (LNA) modification on hybridization kinetics of DNA duplex.
Nucleic acids symposium series (2004) 2008;(52):417-8.
2008: Sunil K Singh; Raman K Sharma; Jyotirmoy Maity; Jesper Wengel; Virinder S Parmar; Ashok K Prasad
Greener biocatalytic approach to the synthesis of nucleosides and their precursors.
Nucleic acids symposium series (2004) 2008;(52):273-4.
2008: Torben Højland; B Ravindra Babu; Jesper Wengel
New conformationally restricted DNA mimics.
Nucleic acids symposium series (2004) 2008;(52):271-2.
2008: Andreas Madsen; Niels Langkjaer; Jesper Wengel
Nucleosides with 1,4-dioxane as sugar moiety.
Nucleic acids symposium series (2004) 2008;(52):269-70.
2008: Troels Bundgaard Jensen; Niels Langkjaer; Jesper Wengel
Unlocked nucleic acid (UNA) and UNA derivatives: thermal denaturation studies.
Nucleic acids symposium series (2004) 2008;(52):133-4.
2008: Dorthe Lindegaard; Andreas Madsen; Irina V Astakhova; Andrei D Malakhov; B Ravindra Babu; Vladimir A Korshun; Jesper Wengel
Pyrene-perylene as a FRET pair coupled to the N2'-functionality of 2'-amino-LNA.
Bioorganic & medicinal chemistry 2008;16(1):94-9.
2007: Tadashi Umemoto; Patrick J Hrdlicka; B Ravindra Babu; Jesper Wengel
Sensitive SNP dual-probe assays based on pyrene-functionalized 2'-amino-LNA: lessons to be learned.
Chembiochem : a European journal of chemical biology 2007;8(18):2240-8.
2007: Stefano Donini; Marcello Clerici; Jesper Wengel; Birte Vester; Alessio Peracchi
The advantages of being locked. Assessing the cleavage of short and long RNAs by locked nucleic acid-containing 8-17 deoxyribozymes.
The Journal of biological chemistry 2007;282(49):35510-8.
2007: Ashok K Prasad; Neerja Kalra; Yogesh Yadav; Sunil K Singh; Sunil K Sharma; Shamkant A Patkar; Lene Lange; Carl E Olsen; Jesper Wengel; Virinder S Parmar
Selective biocatalytic deacylation studies on furanose triesters: a novel and efficient approach towards bicyclonucleosides.
Organic & biomolecular chemistry 2007;5(21):3524-30.
2007: Janne Klitgaard; Sune Lobedanz; Khalil Arar; Jesper Wengel; Birte Vester
LNA nucleotides improve cleavage efficiency of singular and binary hammerhead ribozymes.
Bioorganic & medicinal chemistry 2007;15(18):6135-43.
2007: Torben Højland; Surender Kumar; B Ravindra Babu; Tadashi Umemoto; Nanna Albaek; Pawan K Sharma; Poul Nielsen; Jesper Wengel
LNA (locked nucleic acid) and analogs as triplex-forming oligonucleotides.
Organic & biomolecular chemistry 2007;5(15):2375-9.
2007: Marcin Kalek; Andreas Madsen; Jesper Wengel
Effective modulation of DNA duplex stability by reversible transition metal complex formation in the minor groove.
Journal of the American Chemical Society 2007;129(30):9392-400.
2007: T Santhosh Kumar; Jesper Wengel; Patrick J Hrdlicka
2'-N-(pyren-1-yl)acetyl-2'-amino-alpha-L-LNA: synthesis and detection of single nucleotide mismatches in DNA and RNA targets.
Chembiochem : a European journal of chemical biology 2007;8(10):1122-5.
2007: Ashok K Prasad; Neerja Kalra; Yogesh Yadav; Rajesh Kumar; Sunil K Sharma; Shamkant A Patkar; Lene Lange; Jesper Wengel; Virinder S Parmar
Deacylation studies on furanose triesters using an immobilized lipase: synthesis of a key precursor for bicyclonucleosides.
Chemical communications (Cambridge, England) 2007;(25):2616-7.
2007: Rakesh N Veedu; Birte Vester; Jesper Wengel
Enzymatic incorporation of LNA nucleotides into DNA strands.
Chembiochem : a European journal of chemical biology 2007;8(5):490-2.
2007: Mikala Grubb; Hainer Wackerbarth; Jesper Wengel; Jens Ulstrup
Direct imaging of hexaamine-ruthenium(III) in domain boundaries in monolayers of single-stranded DNA.
Langmuir : the ACS journal of surfaces and colloids 2007;23(3):1410-3.
2007: Harleen Kaur; Jesper Wengel; Souvik Maiti
LNA-modified oligonucleotides effectively drive intramolecular-stable hairpin to intermolecular-duplex state.
Biochemical and biophysical research communications 2007;352(1):118-22.
2007: Ashok K Prasad; Sunil K Singh; Neerja Kalra; Nidhi Singhal; Jesper Wengel; Virinder S Parmar
Novel selective biocatalytic deacylation studies on key precursors for bicyclonucleosides.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1517-21.
2007: Nicolai K Andersen; Jesper Wengel; Patrick J Hrdlicka
N2'-functionalized 2'-amino-alpha-L-LNA adenine derivatives--efficient targeting of single stranded DNA.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1415-7.
2007: Torben Højland; B Ravindra Babu; Torsten Bryld; Jesper Wengel
Triplex-forming ability of modified oligonucleotides.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1411-4.
2007: T Santhosh Kumar; Jesper Wengel; Patrick J Hrdlicka
Pyrene-functionalized 2'-amino-alpha-L-LNA as potential diagnostic probes.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1407-9.
2007: T Santhosh Kumar; Andreas Madsen; Jesper Wengel; Patrick J Hrdlicka
Synthesis and biophysical studies of N2'-functionalized 2'-amino-alpha-L-LNA.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1403-5.
2007: Tadashi Umemoto; Patrick J Hrdlicka; B Ravindra Babu; Jesper Wengel
Dual-probe system using pyrenylmethyl-modified amino-LNA for mismatch detection.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1261-3.
2007: Rakesh N Veedu; Birte Vester; Jesper Wengel
In vitro incorporation of LNA nucleotides.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1207-10.
2007: Rakesh N Veedu; Birte Vester; Jesper Wengel
Novel applications of locked nucleic acids.
Nucleic acids symposium series (2004) 2007;(51):29-30.
2007: Jesper B Bramsen; Maria B Laursen; Christian K Damgaard; Suzy W Lena; B Ravindra Babu; Jesper Wengel; Jørgen Kjems
Improved silencing properties using small internally segmented interfering RNAs.
Nucleic acids research 2007;35(17):5886-97.
2007: Martin R Jakobsen; Martin Roelsgaard Jakobsen; Jesper Wengel; Ben Berkhout; Jørgen Kjems
Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites.
Retrovirology 2007;4():29.
2006: Andreas Madsen; Patrick J Hrdlicka; T Santhosh Kumar; Jesper Wengel
Synthesis, nucleic acid hybridization properties and molecular modelling studies of conformationally restricted 3'-O,4'-C-methylene-linked alpha-L-ribonucleotides.
Carbohydrate research 2006;341(10):1398-407.
2006: Neerja Kalra; Maria C Parlato; Virinder S Parmar; Jesper Wengel
DNA and LNA oligonucleotides containing N2'-functionalised derivatives of 2'-amino-2'-deoxyuridine.
Bioorganic & medicinal chemistry letters 2006;16(12):3166-9.
2006: Harleen Kaur; Amit Arora; Jesper Wengel; Souvik Maiti
Thermodynamic, counterion, and hydration effects for the incorporation of locked nucleic acid nucleotides into DNA duplexes.
Biochemistry 2006;45(23):7347-55.
2006: T Santhosh Kumar; Andreas Madsen; Jesper Wengel; Patrick J Hrdlicka
Synthesis and hybridization studies of 2'-amino-alpha-L-LNA and tetracyclic "locked LNA".
The Journal of organic chemistry 2006;71(11):4188-201.
2006: Birte Vester; Lars Hestbjerg Hansen; Lars Bo Lundberg; B Ravindra Babu; Mads D Sørensen; Jesper Wengel; Stephen Douthwaite
Locked nucleoside analogues expand the potential of DNAzymes to cleave structured RNA targets.
BMC molecular biology 2006;7():19.
2006: Dorthe Lindegaard; David O Wood; Jesper Wengel; Jeremy S Lee
Electron injection from the side of an M-DNA duplex.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2006;11(1):82-7.
2005: Patrick J Hrdlicka; B Ravindra Babu; Mads D Sørensen; Niels Harrit; Jesper Wengel
Multilabeled pyrene-functionalized 2'-amino-LNA probes for nucleic acid detection in homogeneous fluorescence assays.
Journal of the American Chemical Society 2005;127(38):13293-9.
2005: Patrick J Hrdlicka; T Santhosh Kumar; Jesper Wengel
Targeting of mixed sequence double-stranded DNA using pyrene-functionalized 2'-amino-alpha-l-LNA.
Chemical communications (Cambridge, England) 2005;(34):4279-81.
2005: Vyacheslav V Filichev; Birte Vester; Lars Hestbjerg Hansen; Mohammed T Abdel Aal; B Ravindra Babu; Jesper Wengel; Erik B Pedersen
Enhanced inhibition of transcription start by targeting with 2'-OMe pentaribonucleotides comprising locked nucleic acids and intercalating nucleic acids.
Chembiochem : a European journal of chemical biology 2005;6(7):1181-4.
2005: Erika Brunet; Patrizia Alberti; Loïc Perrouault; Ravindra Babu; Jesper Wengel; Carine Giovannangeli
Exploring cellular activity of locked nucleic acid-modified triplex-forming oligonucleotides and defining its molecular basis.
The Journal of biological chemistry 2005;280(20):20076-85.
2005: B Ravindra Babu; Patrick J Hrdlicka; Christine J McKenzie; Jesper Wengel
Optimized DNA targeting using N,N-bis(2-pyridylmethyl)-beta-alanyl 2'-amino-LNA.
Chemical communications (Cambridge, England) 2005;(13):1705-7.
2005: Patrick J Hrdlicka; Nicolai K Andersen; Stenvang Jan; Flemming G Hansen; Kim F Haselmann; Claus Nielsen; Jesper Wengel
Synthesis and biological evaluation of branched and conformationally restricted analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd).
Bioorganic & medicinal chemistry 2005;13(7):2597-621.
2005: Patrick J Hrdlicka; Stenvang Jan; Claus Nielsen; Jesper Wengel
Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd).
Bioorganic & medicinal chemistry 2005;13(4):1249-60.
2005: Michael Raunkjaer; Mads D Sørensen; Jesper Wengel
Synthesis and thermal denaturation studies of novel 2'-O,3'-C-linked bicyclic oligonucleotides with a methoxy or a piperazino group facing the major groove of nucleic acid duplexes.
Organic & biomolecular chemistry 2005;3(1):130-5.
2005: Patrick J Hrdlicka; T Santhosh Kumar; Jesper Wengel
Synthesis of a 2'-amino-alpha-1-LNA-T phosphoramidite.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):1101-4.
2005: Dorthe Lindegaard; B Ravindra Babu; Jesper Wengel
DNA self-assembling systems: branched oligonucleotides as building blocks and monitoring by pyrene excimer band formation.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):679-81.
2005: Patrick J Hrdlicka; Stenvang Jan; Jesper Wengel
Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd).
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):397-400.
2005: Erika Brunet; Maddalena Corgnali; Loïc Perrouault; Victoria Roig; Ulysse Asseline; Mads D Sørensen; B Ravindra Babu; Jesper Wengel; Carine Giovannangeli
Intercalator conjugates of pyrimidine locked nucleic acid-modified triplex-forming oligonucleotides: improving DNA binding properties and reaching cellular activities.
Nucleic acids research 2005;33(13):4223-34.
2005: Henrik M Pfundheller; Anders M Sørensen; Christian Lomholt; Anders M Johansen; Troels Koch; Jesper Wengel
Locked nucleic acid synthesis.
Methods in molecular biology (Clifton, N.J.) 2005;288():127-46.
2004: Vyacheslav V Filichev; Ulf B Christensen; Erik B Pedersen; B Ravindra Babu; Jesper Wengel
Locked nucleic acids and intercalating nucleic acids in the design of easily denaturing nucleic acids: thermal stability studies.
Chembiochem : a European journal of chemical biology 2004;5(12):1673-9.
2004: Birte Vester; Jesper Wengel
LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA.
Biochemistry 2004;43(42):13233-41.
2004: Neerja Kalra; B Ravindra Babu; Virinder S Parmar; Jesper Wengel
Conformationally controlled high-affinity targeting of RNA or DNA by novel 2'-amino-DNA/LNA mixmers and pyrenyl-functionalized 2'-amino-DNA.
Organic & biomolecular chemistry 2004;2(20):2885-7.
2004: Michael Meldgaard; Flemming Gundorph Hansen; Jesper Wengel
3'-C-Branched LNA-type nucleosides locked in an N-type furanose ring conformation: synthesis, incorporation into oligodeoxynucleotides, and hybridization studies.
The Journal of organic chemistry 2004;69(19):6310-22.
2004: Patrick J Hrdlicka; B Ravindra Babu; Mads D Sørensen; Jesper Wengel
Interstrand communication between 2'-N-(pyren-1-yl)methyl-2'-amino-LNA monomers in nucleic acid duplexes: directional control and signalling of full complementarity.
Chemical communications (Cambridge, England) 2004;(13):1478-9.
2004: Torsten Bryld; Torben Hojland; Jesper Wengel
DNA-selective hybridization and dual strand invasion of short double-stranded DNA using pyren-1-ylcarbonyl-functionalized 4'-C-piperazinomethyl-DNA.
Chemical communications (Cambridge, England) 2004;(9):1064-5.
2004: Katrine E Nielsen; Jill Rasmussen; Ravindra Kumar; Jesper Wengel; Jens Peter Jacobsen; Michael Petersen
NMR studies of fully modified locked nucleic acid (LNA) hybrids: solution structure of an LNA:RNA hybrid and characterization of an LNA:DNA hybrid.
Bioconjugate chemistry 2004;15(3):449-57.
2004: Bei-Wen Sun; B Ravindra Babu; Mads D Sørensen; Krystyna Zakrzewska; Jesper Wengel; Jian-Sheng Sun
Sequence and pH effects of LNA-containing triple helix-forming oligonucleotides: physical chemistry, biochemistry, and modeling studies.
Biochemistry 2004;43(14):4160-9.
2004: Stenvang Jan; Jesper Wengel
LNA-antisense rivals siRNA for gene silencing.
Current opinion in drug discovery & development 2004;7(2):188-94.
2004: Jesper Wengel
Nucleic acid nanotechnology-towards Angstrom-scale engineering.
Organic & biomolecular chemistry 2004;2(3):277-80.
2004: Nanna K Christensen; Torsten Bryld; Mads D Sørensen; Khalil Arar; Jesper Wengel; Poul Nielsen
Parallel nucleic acid recognition by the LNA (locked nucleic acid) stereoisomers beta-L-LNA and alpha-D-LNA; studies in the mirror image world.
Chemical communications (Cambridge, England) 2004;(3):282-3.
2004: Birte Vester; Lars Bo Lundberg; Mads D Sørensen; B Ravindra Babu; Stephen Douthwaite; Jesper Wengel
Improved RNA cleavage by LNAzyme derivatives of DNAzymes.
Biochemical Society transactions 2004;32(Pt 1):37-40.
2004: B Ravindra Babu; Mads D Sørensen; Virinder S Parmar; Niels Harrit; Jesper Wengel
Oligodeoxynucleotides containing alpha-L-ribo configured LNA-type C-aryl nucleotides.
Organic & biomolecular chemistry 2004;2(1):80-9.
2004: Stenvang Jan; Mads D Sørensen; Jesper Wengel
Locked nucleic acid: a potent nucleic acid analog in therapeutics and biotechnology.
Oligonucleotides 2004;14(2):130-46.
2004: Rita Crinelli; Marzia Bianchi; Lucia Gentilini; Linda Palma; Mads D Sørensen; Torsten Bryld; Ravindra B Babu; Khalil Arar; Jesper Wengel; Mauro Magnani
Transcription factor decoy oligonucleotides modified with locked nucleic acids: an in vitro study to reconcile biostability with binding affinity.
Nucleic acids research 2004;32(6):1874-85.
2003: B Ravindra Babu; Lise Keinicke; Michael Petersen; Claus Nielsen; Jesper Wengel
2'-Spiro ribo- and arabinonucleosides: synthesis, molecular modelling and incorporation into oligodeoxynucleotides.
Organic & biomolecular chemistry 2003;1(20):3514-26.
2003: Mads D Sørensen; Michael Petersen; Jesper Wengel
Functionalized LNA (locked nucleic acid): high-affinity hybridization of oligonucleotides containing N-acylated and N-alkylated 2'-amino-LNA monomers.
Chemical communications (Cambridge, England) 2003;(17):2130-1.
2003: Nicolai E Poopeiko; Martin Juhl; Birte Vester; Mads D Sørensen; Jesper Wengel
Xylo-Configured oligonucleotides (XNA, xylo nucleic acid): synthesis of conformationally restricted derivatives and hybridization towards DNA and RNA complements.
Bioorganic & medicinal chemistry letters 2003;13(14):2285-90.
2003: Michael Raunkjaer; Torsten Bryld; Jesper Wengel
N-methylpiperazinocarbonyl-2',3'-BcNA and 4'-C-(N-methylpiperazino)methyl-DNA: introduction of basic functionalities facing the major groove and the minor groove of a DNA:DNA duplex.
Chemical communications (Cambridge, England) 2003;(13):1604-5.
2003: Henning V Tømmerholt; Nanna K Christensen; Poul Nielsen; Jesper Wengel; Paul C Stein; Jens Peter Jacobsen; Michael Petersen
NMR solution structure of dsDNA containing a bicyclic D-arabino-configured nucleotide fixed in an O4'-endo sugar conformation.
Organic & biomolecular chemistry 2003;1(10):1790-7.
2003: Michael Petersen; Jakob T Nielsen; Kent Bondensgaard; Jesper Wengel; Jens Peter Jacobsen
Structural characterization of LNA and alpha-L-LNA hybridized to RNA.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1691-3.
2003: B Ravindra Babu; Jesper Wengel
Aryl-beta-C-LNA monomers as universal hybridization probes.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1317-9.
2003: B Ravindra Babu; Lise Keinicke; Jesper Wengel
Synthesis of 2'-spiro ribo- and arabinonucleosides.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1313-5.
2003: Torsten Bryld; Jesper Wengel
Synthesis of a base-protected xylo-LNA adenine nucleoside.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1163-5.
2003: Dorthe Lindegaard; Jesper Wengel
Synthesis and hybridization properties of oligodeoxynucleotides containing 3'-deoxy-3'-C-methyleneuridine.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1159-61.
2003: Gilles Gaubert; Jesper Wengel
Synthesis of a base-protected alpha-L-LNA guanine nucleoside.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1155-7.
2003: Nicolai E Poopeiko; Britta M Dahl; Jesper Wengel
xylo-configured oligonucleotides (XNA, xylo nucleic acids): synthesis and hybridization studies.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1147-9.
2003: Signe M Christensen; Christoph Rosenbohm; Mads Sørensen; Lotte-Emilie Larsen; Jesper Wengel; Troels Koch
Improved synthesis of 2'-amino-LNA.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1131-3.
2003: Stefan Vogel; Katja Rohr; Otto Dahl; Jesper Wengel
Synthesis of an asymmetrically substituted AZA crown ether as metal and amino acid binding site in DNA conjugates.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1039-40.
2003: Jesper Wengel; Birte Vester; Lars Bo Lundberg; Stephen Douthwaite; Mads D Sørensen; B Ravindra Babu; Michael J Gait; Andrey A Arzumanov; Michael Petersen; Jakob T Nielsen
LNA and alpha-L-LNA: towards therapeutic applications.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):601-4.
2003: Stefan Vogel; Katja Rohr; Otto Dahl; Jesper Wengel
A substituted triaza crown ether as a binding site in DNA conjugates.
Chemical communications (Cambridge, England) 2003;(8):1006-7.
2003: Christoph Rosenbohm; Signe M Christensen; Mads D Sørensen; Daniel Sejer Pedersen; Lotte-Emilie Larsen; Jesper Wengel; Troels Koch
Synthesis of 2'-amino-LNA: a new strategy.
Organic & biomolecular chemistry 2003;1(4):655-63.
2003: Michael Petersen; Jesper Wengel
LNA: a versatile tool for therapeutics and genomics.
Trends in biotechnology 2003;21(2):74-81.
2003: Anne Lauritsen; Britta M Dahl; Otto Dahl; Birte Vester; Jesper Wengel
Methylphosphonate LNA: a locked nucleic acid with a methylphosphonate linkage.
Bioorganic & medicinal chemistry letters 2003;13(2):253-6.
2003: Andrey A Arzumanov; Dmitry A Stetsenko; Andrei D Malakhov; Stefanie Reichelt; Mads D Sørensen; B Ravindra Babu; Jesper Wengel; Michael J Gait
A structure-activity study of the inhibition of HIV-1 Tat-dependent trans-activation by mixmer 2'-O-methyl oligoribonucleotides containing locked nucleic acid (LNA), alpha-L-LNA, or 2'-thio-LNA residues.
Oligonucleotides 2003;13(6):435-53.
2002: Birte Vester; Lars Bo Lundberg; Mads D Sørensen; B Ravindra Babu; Stephen Douthwaite; Jesper Wengel
LNAzymes: incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage.
Journal of the American Chemical Society 2002;124(46):13682-3.
2002: Helena Thomasen; Michael Meldgaard; Morten Freitag; Michael Petersen; Jesper Wengel; Poul Nielsen
3',4'-trans-linked bicyclic nucleosides locked in S-type conformations.
Chemical communications (Cambridge, England) 2002;(17):1888-9.
2002: Katrine M Ellemann Nielsen; Michael Petersen; Anders E Håkansson; Jesper Wengel; Jens Peter Jacobsen
alpha-L-LNA (alpha-L-ribo configured locked nucleic acid) recognition of DNA: an NMR spectroscopic study.
Chemistry (Weinheim an der Bergstrasse, Germany) 2002;8(13):3001-9.
2002: Michael Petersen; Kent Bondensgaard; Jesper Wengel; Jens Peter Jacobsen
Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids.
Journal of the American Chemical Society 2002;124(21):5974-82.
2002: Mads D Sørensen; Lisbet Kvaernø; Torsten Bryld; Anders E Håkansson; Birgit Verbeure; Gilles Gaubert; Piet Herdewijn; Jesper Wengel
alpha-L-ribo-configured locked nucleic acid (alpha-L-LNA): synthesis and properties.
Journal of the American Chemical Society 2002;124(10):2164-76.
2002: Anne Lauritsen; Jesper Wengel
Oligodeoxynucleotides containing amide-linked LNA-type dinucleotides: synthesis and high-affinity nucleic acid hybridization.
Chemical communications (Cambridge, England) 2002;(5):530-1.
2002: Lise Keinicke; Mads D Sørensen; Jesper Wengel
Alpha-L-RNA (alpha-L-ribo configured RNA): synthesis and RNA-selective hybridization of alpha-L-RNA/alpha-L-LNA chimera.
Bioorganic & medicinal chemistry letters 2002;12(4):593-6.
2001: Andrey A Arzumanov; Andrew P Walsh; V K Rajwanshi; R Kumar; Jesper Wengel; Michael J Gait
Inhibition of HIV-1 Tat-dependent trans activation by steric block chimeric 2'-O-methyl/LNA oligoribonucleotides.
Biochemistry 2001;40(48):14645-54.
2001: B Ravindra Babu; Jesper Wengel
Universal hybridization using LNA (locked nucleic acid) containing a novel pyrene LNA nucleotide monomer.
Chemical communications (Cambridge, England) 2001;(20):2114-5.
2001: Lisbet Kvaernø; Jesper Wengel
Novel bicyclic nucleoside analogue (1S,5S,6S)-6- hydroxy-5-hydroxymethyl-1-(uracil-1-yl)-3,8-dioxabicyclo[3.2.1]octane: synthesis and incorporation into oligodeoxynucleotides.
The Journal of organic chemistry 2001;66(16):5498-503.
2001: Michael Petersen; Anders E Håkansson; Jesper Wengel; Jens Peter Jacobsen
alpha-L-LNA (alpha-I-ribo configured locked nucleic acid) recognition of RNA. A study by NMR spectroscopy and molecular dynamics simulations.
Journal of the American Chemical Society 2001;123(30):7431-2.
2001: Lisbet Kvaernø; R H Wightman; Jesper Wengel
Synthesis of a novel bicyclic nucleoside restricted to an S-type conformation and initial evaluation of its hybridization properties when incorporated into oligodeoxynucleotides.
The Journal of organic chemistry 2001;66(15):5106-12.
2001: A E Håkansson; Jesper Wengel
The adenine derivative of alpha-L-LNA (alpha-L-ribo configured locked nucleic acid): synthesis and high-affinity hybridization towards DNA, RNA, LNA and alpha-L-LNA complementary sequences.
Bioorganic & medicinal chemistry letters 2001;11(7):935-8.
2001: Andrey A Arzumanov; Andrew P Walsh; X Liu; V K Rajwanshi; Jesper Wengel; Michael J Gait
Oligonucleotide analogue interference with the HIV-1 Tat protein-TAR RNA interaction.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):471-80.
2001: Jesper Wengel; Michael Petersen; Katrine E Nielsen; G A Jensen; Anders E Håkansson; Ravindra Kumar; Mads D Sørensen; VK Rajwanshi; Torsten Bryld; Jens Peter Jacobsen
LNA (locked nucleic acid) and the diastereoisomeric alpha-L-LNA: conformational tuning and high-affinity recognition of DNA/RNA targets.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):389-96.
2001: Ulla Christensen; N Jacobsen; VK Rajwanshi; Jesper Wengel; T Koch
Stopped-flow kinetics of locked nucleic acid (LNA)-oligonucleotide duplex formation: studies of LNA-DNA and DNA-DNA interactions.
The Biochemical journal 2001;354(Pt 3):481-4.
2001: Mads D Sørensen; Lisbet Kvaernø; Torsten Bryld; Anders E Håkansson; Lise Keinicke; Birgit Verbeure; Piet Herdewijn; Jesper Wengel
The alpha-L-ribo-isomers of RNA and LNA (locked nucleic acid).
Nucleic acids research. Supplement (2001) 2001;(1):25-6.
2000: Lisbet Kvaernø; R Kumar; Britta M Dahl; C E Olsen; Jesper Wengel
Synthesis of abasic locked nucleic acid and two seco-LNA derivatives and evaluation of their hybridization properties compared with their more flexible DNA counterparts.
The Journal of organic chemistry 2000;65(17):5167-76.
2000: Mads D Sørensen; Michael Meldgaard; Michael Raunkjaer; VK Rajwanshi; Jesper Wengel
Branched oligonucleotides containing bicyclic nucleotides as branching points and DNA or LNA as triplex forming branch.
Bioorganic & medicinal chemistry letters 2000;10(16):1853-6.
2000: Kent Bondensgaard; Michael Petersen; SK Singh; VK Rajwanshi; Ravindra Kumar; Jesper Wengel; Jens Peter Jacobsen
Structural studies of LNA:RNA duplexes by NMR: conformations and implications for RNase H activity.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(15):2687-95.
2000: L B Jørgensen; Poul Nielsen; Jesper Wengel; Jens Peter Jacobsen
The solution structure of a DNA duplex containing a single 1-(2-O,3-C-ethylene-beta-D-arabinofuranosyl)thymidine nucleoside.
Journal of biomolecular structure & dynamics 2000;18(1):45-57.
2000: Katrine E Nielsen; SK Singh; Jesper Wengel; Jens Peter Jacobsen
Solution structure of an LNA hybridized to DNA: NMR study of the d(CT(L)GCT(L)T(L)CT(L)GC):d(GCAGAAGCAG) duplex containing four locked nucleotides.
Bioconjugate chemistry 2000;11(2):228-38.
2000: Michael Petersen; Christina B Nielsen; Katrine E Nielsen; G A Jensen; Kent Bondensgaard; SK Singh; VK Rajwanshi; Alexei Koshkin; Britta M Dahl; Jesper Wengel; Jens Peter Jacobsen
The conformations of locked nucleic acids (LNA).
Journal of molecular recognition : JMR 2000;13(1):44-53.
1999: Christina B Nielsen; SK Singh; Jesper Wengel; Jens Peter Jacobsen
The solution structure of a locked nucleic acid (LNA) hybridized to DNA.
Journal of biomolecular structure & dynamics 1999;17(2):175-91.
1999: Henrik M Pfundheller; Jesper Wengel
Oligonucleotides containing 4'-C-aminomethyl-2'-modified thymidines show increased binding affinity towards DNA and RNA.
Bioorganic & medicinal chemistry letters 1999;9(18):2667-72.
1999: Henrik M Pfundheller; Alexei Koshkin; C E Olsen; Jesper Wengel
Evaluation of oligonucleotides containing two novel 2'-O-methyl modified nucleotide monomers: a 3'-C-allyl and a 2'-O,3'-C-linked bicyclic derivative.
Nucleosides & nucleotides 1999;18(9):2017-30.
1998: R Kumar; S K Singh; Alexei Koshkin; VK Rajwanshi; Michael Meldgaard; Jesper Wengel
The first analogues of LNA (locked nucleic acids): phosphorothioate-LNA and 2'-thio-LNA.
Bioorganic & medicinal chemistry letters 1998;8(16):2219-22.