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Jesper Wengel

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
27
Babu, Ravindra
22
Sørensen, Mads
20
Hrdlicka, Patrick
18
Vester, Birte
14
Petersen, Michael
12
Jacobsen, Jens Peter
10
Kumar, Santhosh
9
Bryld, Torsten
8
Parmar, Virinder
8
Veedu, Rakesh
7
Nielsen, Poul
7
Madsen, Andreas
6
Rajwanshi, VK
5
Maiti, Souvik
5
Kvaernø, Lisbet

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Publications

TOP 3
Hernandez Frank J; Kalra Neerja; Wengel Jesper; Vester Birte
Aptamers as a model for functional evaluation of LNA and 2'-amino LNA.
Karlsen Kasper K; Jensen Troels B; Wengel Jesper
Synthesis of an unlocked nucleic acid terpyridine monomer and binding of divalent metal ion in nucleic acid duplexes.
Langkjaer Niels; Pasternak Anna; Wengel Jesper
UNA (unlocked nucleic acid): a flexible RNA mimic that allows engineering of nucleic acid duplex stability.

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All Publications

2009: Hernandez Frank J; Kalra Neerja; Wengel Jesper; Vester Birte
Aptamers as a model for functional evaluation of LNA and 2'-amino LNA.
Bioorganic & medicinal chemistry letters 2009;19(23):6585-7.
2009: Karlsen Kasper K; Jensen Troels B; Wengel Jesper
Synthesis of an unlocked nucleic acid terpyridine monomer and binding of divalent metal ion in nucleic acid duplexes.
The Journal of organic chemistry 2009;74(22):8838-41.
2009: Langkjaer Niels; Pasternak Anna; Wengel Jesper
UNA (unlocked nucleic acid): a flexible RNA mimic that allows engineering of nucleic acid duplex stability.
Bioorganic & medicinal chemistry 2009;17(15):5420-5.
2009: Fluiter Kees; Mook Olaf R F; Vreijling Jeroen; Langkjaer Niels; Højland Torben; Wengel Jesper; Baas Frank
Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4'-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer.
Molecular bioSystems 2009;5(8):838-43.
2009: Veedu Rakesh N; Wengel Jesper
Locked nucleic acid nucleoside triphosphates and polymerases: on the way towards evolution of LNA aptamers.
Molecular bioSystems 2009;5(8):787-92.
2009: Veedu Rakesh N; Wengel Jesper
Locked nucleic acid as a novel class of therapeutic agents.
RNA biology 2009;6(3):321-3.
2009: Gao Shan; Dagnaes-Hansen Frederik; Nielsen Ebbe Juel Bech; Wengel Jesper; Besenbacher Flemming; Howard Kenneth Alan; Kjems Jørgen
The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(7):1225-33.
2009: Gupta Pankaj; Maity Jyotirmoy; Shakya Gaurav; Prasad Ashok K; Parmar Virinder S; Wengel Jesper
Synthesis and hybridization studies of alpha-configured arabino nucleic acids.
Organic & biomolecular chemistry 2009;7(11):2389-401.
2009: Glud Sys Zoffmann; Bramsen Jesper B; Dagnaes-Hansen Frederik; Wengel Jesper; Howard Kenneth Alan; Nyengaard Jens R; Kjems Jørgen
Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration.
Oligonucleotides 2009;19(2):163-8.
2009: Umemoto Tadashi; Wengel Jesper; Madsen Andreas Stahl
Functionalization of 2'-amino-LNA with additional nucleobases.
Organic & biomolecular chemistry 2009;7(9):1793-7.
2009: Nagahama Koji; Veedu Rakesh N; Wengel Jesper
Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides.
Bioorganic & medicinal chemistry letters 2009;19(10):2707-9.
2009: Kumar T Santhosh; Ostergaard Michael E; Sharma Pawan K; Nielsen Poul; Wengel Jesper; Hrdlicka Patrick J
Parallel RNA-strand recognition by 2'-amino-beta-L-LNA.
Bioorganic & medicinal chemistry letters 2009;19(9):2396-9.
2009: Veedu Rakesh N; Vester Birte; Wengel Jesper
Efficient enzymatic synthesis of LNA-modified DNA duplexes using KOD DNA polymerase.
Organic & biomolecular chemistry 2009;7(7):1404-9.
2009: Kumar T Santhosh; Madsen Andreas S; Østergaard Michael E; Sau Sujay P; Wengel Jesper; Hrdlicka Patrick J
Functionalized 2'-amino-alpha-L-LNA: directed positioning of intercalators for DNA targeting.
The Journal of organic chemistry 2009;74(3):1070-81.
2008: Astakhova Irina V; Korshun Vladimir A; Jahn Kasper; Kjems Jørgen; Wengel Jesper
Perylene attached to 2'-amino-LNA: synthesis, incorporation into oligonucleotides, and remarkable fluorescence properties in vitro and in cell culture.
Bioconjugate chemistry 2008;19(10):1995-2007.
2008: Kumar T Santhosh; Madsen Andreas S; Østergaard Michael E; Wengel Jesper; Hrdlicka Patrick J
Nucleic acid structural engineering using pyrene-functionalized 2'-amino-alpha-L-LNA monomers and abasic sites.
The Journal of organic chemistry 2008;73(18):7060-6.
2008: Dutkiewicz Mariola; Grunert Hans-Peter; Zeichhardt Heinz; Lena Suzy W; Wengel Jesper; Kurreck Jens
Design of LNA-modified siRNAs against the highly structured 5' UTR of coxsackievirus B3.
FEBS letters 2008;582(20):3061-6.
2008: Veedu Rakesh N; Vester Birte; Wengel Jesper
Polymerase chain reaction and transcription using locked nucleic acid nucleotide triphosphates.
Journal of the American Chemical Society 2008;130(26):8124-5.
2008: Guterstam Peter; Lindgren Maria; Johansson Henrik; Tedebark Ulf; Wengel Jesper; El Andaloussi Samir; Langel Ulo
Splice-switching efficiency and specificity for oligonucleotides with locked nucleic acid monomers.
The Biochemical journal 2008;412(2):307-13.
2008: Vester Birte; Boel Anne Marie; Lobedanz Sune; Babu B Ravindra; Raunkjaer Michael; Lindegaard Dorthe; Raunak; Hrdlicka Patrick J; Højland Torben; Sharma Pawan K; Kumar Surender; Nielsen Poul; Wengel Jesper
Chemically modified oligonucleotides with efficient RNase H response.
Bioorganic & medicinal chemistry letters 2008;18(7):2296-300.
2008: Kalek Marcin; Benediktson Peter; Vester Birte; Wengel Jesper
Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach.
Chemical communications (Cambridge, England) 2008;(6):762-4.
2008: Kaur Harleen; Wengel Jesper; Maiti Souvik
Thermodynamics of DNA-RNA heteroduplex formation: effects of locked nucleic acid nucleotides incorporated into the DNA strand.
Biochemistry 2008;47(4):1218-27.
2008: Desnous Céline; Babu B Ravindra; Moriou Céline; Mayo Javier Ulises Ortiz; Favre Alain; Wengel Jesper; Clivio Pascale
The sugar conformation governs (6-4) photoproduct formation at the dinucleotide level.
Journal of the American Chemical Society 2008;130(1):30-1.
2008: Lindegaard Dorthe; Madsen Andreas S; Astakhova Irina V; Malakhov Andrei D; Babu B Ravindra; Korshun Vladimir A; Wengel Jesper
Pyrene-perylene as a FRET pair coupled to the N2'-functionality of 2'-amino-LNA.
Bioorganic & medicinal chemistry 2008;16(1):94-9.
2008: Astakhova Irina V; Korshun Vladimir A; Wengel Jesper
Highly fluorescent conjugated pyrenes in nucleic acid probes: (phenylethynyl)pyrenecarbonyl-functionalized locked nucleic acids.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(35):11010-26.
2008: Kaur Harleen; Arora Amit; Wengel Jesper; Maiti Souvik
Thermodynamic, counterion and hydration effects for the incorporation of locked nucleic acid (LNA) nucleotides in duplex.
Nucleic acids symposium series (2004) 2008;(52):425-6.
2008: Arora Amit; Kaur Harleen; Wengel Jesper; Maiti Souvik
Effect of locked nucleic acid (LNA) modification on hybridization kinetics of DNA duplex.
Nucleic acids symposium series (2004) 2008;(52):417-8.
2008: Singh Sunil K; Sharma Raman K; Maity Jyotirmoy; Wengel Jesper; Parmar Virinder S; Prasad Ashok K
Greener biocatalytic approach to the synthesis of nucleosides and their precursors.
Nucleic acids symposium series (2004) 2008;(52):273-4.
2008: Højland Torben; Babu B Ravindra; Wengel Jesper
New conformationally restricted DNA mimics.
Nucleic acids symposium series (2004) 2008;(52):271-2.
2008: Madsen Andreas Stahl; Langkjaer Niels; Wengel Jesper
Nucleosides with 1,4-dioxane as sugar moiety.
Nucleic acids symposium series (2004) 2008;(52):269-70.
2008: Jensen Troels Bundgaard; Langkjaer Niels; Wengel Jesper
Unlocked nucleic acid (UNA) and UNA derivatives: thermal denaturation studies.
Nucleic acids symposium series (2004) 2008;(52):133-4.
2007: Umemoto Tadashi; Hrdlicka Patrick J; Babu B Ravindra; Wengel Jesper
Sensitive SNP dual-probe assays based on pyrene-functionalized 2'-amino-LNA: lessons to be learned.
Chembiochem : a European journal of chemical biology 2007;8(18):2240-8.
2007: Donini Stefano; Clerici Marcello; Wengel Jesper; Vester Birte; Peracchi Alessio
The advantages of being locked. Assessing the cleavage of short and long RNAs by locked nucleic acid-containing 8-17 deoxyribozymes.
The Journal of biological chemistry 2007;282(49):35510-8.
2007: Prasad Ashok K; Kalra Neerja; Yadav Yogesh; Singh Sunil K; Sharma Sunil K; Patkar Shamkant; Lange Lene; Olsen Carl E; Wengel Jesper; Parmar Virinder S
Selective biocatalytic deacylation studies on furanose triesters: a novel and efficient approach towards bicyclonucleosides.
Organic & biomolecular chemistry 2007;5(21):3524-30.
2007: Christiansen Janne K; Lobedanz Sune; Arar Khalil; Wengel Jesper; Vester Birte
LNA nucleotides improve cleavage efficiency of singular and binary hammerhead ribozymes.
Bioorganic & medicinal chemistry 2007;15(18):6135-43.
2007: Højland Torben; Kumar Surender; Babu B Ravindra; Umemoto Tadashi; Albaek Nanna; Sharma Pawan K; Nielsen Poul; Wengel Jesper
LNA (locked nucleic acid) and analogs as triplex-forming oligonucleotides.
Organic & biomolecular chemistry 2007;5(15):2375-9.
2007: Kalek Marcin; Madsen Andreas S; Wengel Jesper
Effective modulation of DNA duplex stability by reversible transition metal complex formation in the minor groove.
Journal of the American Chemical Society 2007;129(30):9392-400.
2007: Prasad Ashok K; Kalra Neerja; Yadav Yogesh; Kumar Rajesh; Sharma Sunil K; Patkar Shamkant; Lange Lene; Wengel Jesper; Parmar Virinder S
Deacylation studies on furanose triesters using an immobilized lipase: synthesis of a key precursor for bicyclonucleosides.
Chemical communications (Cambridge, England) 2007;(25):2616-7.
2007: Kumar T Santhosh; Wengel Jesper; Hrdlicka Patrick J
2'-N-(pyren-1-yl)acetyl-2'-amino-alpha-L-LNA: synthesis and detection of single nucleotide mismatches in DNA and RNA targets.
Chembiochem : a European journal of chemical biology 2007;8(10):1122-5.
2007: Veedu Rakesh N; Vester Birte; Wengel Jesper
Enzymatic incorporation of LNA nucleotides into DNA strands.
Chembiochem : a European journal of chemical biology 2007;8(5):490-2.
2007: Grubb Mikala; Wackerbarth Hainer; Wengel Jesper; Ulstrup Jens
Direct imaging of hexaamine-ruthenium(III) in domain boundaries in monolayers of single-stranded DNA.
Langmuir : the ACS journal of surfaces and colloids 2007;23(3):1410-3.
2007: Kaur Harleen; Wengel Jesper; Maiti Souvik
LNA-modified oligonucleotides effectively drive intramolecular-stable hairpin to intermolecular-duplex state.
Biochemical and biophysical research communications 2007;352(1):118-22.
2007: Prasad Ashok K; Singh Sunil K; Kalra Neerja; Singhal Nidhi; Wengel Jesper; Parmar Virinder S
Novel selective biocatalytic deacylation studies on key precursors for bicyclonucleosides.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1517-21.
2007: Andersen Nicolai K; Wengel Jesper; Hrdlicka Patrick J
N2'-functionalized 2'-amino-alpha-L-LNA adenine derivatives--efficient targeting of single stranded DNA.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1415-7.
2007: Højland Torben; Babu B Ravindra; Bryld Torsten; Wengel Jesper
Triplex-forming ability of modified oligonucleotides.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1411-4.
2007: Kumar T Santhosh; Wengel Jesper; Hrdlicka Patrick J
Pyrene-functionalized 2'-amino-alpha-L-LNA as potential diagnostic probes.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1407-9.
2007: Kumar T Santhosh; Madsen Andreas S; Wengel Jesper; Hrdlicka Patrick J
Synthesis and biophysical studies of N2'-functionalized 2'-amino-alpha-L-LNA.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1403-5.
2007: Umemoto Tadashi; Hrdlicka Patrick J; Babu B Ravindra; Wengel Jesper
Dual-probe system using pyrenylmethyl-modified amino-LNA for mismatch detection.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1261-3.
2007: Veedu Rakesh N; Vester Birte; Wengel Jesper
In vitro incorporation of LNA nucleotides.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1207-10.
2007: Veedu Rakesh N; Vester Birte; Wengel Jesper
Novel applications of locked nucleic acids.
Nucleic acids symposium series (2004) 2007;(51):29-30.
2007: Bramsen Jesper B; Laursen Maria B; Damgaard Christian K; Lena Suzy W; Babu B Ravindra; Wengel Jesper; Kjems Jørgen
Improved silencing properties using small internally segmented interfering RNAs.
Nucleic acids research 2007;35(17):5886-97.
2007: Jakobsen Martin R; Haasnoot Joost; Wengel Jesper; Berkhout Ben; Kjems Jørgen
Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites.
Retrovirology 2007;4():29.
2006: Madsen Andreas S; Hrdlicka Patrick J; Kumar T Santhosh; Wengel Jesper
Synthesis, nucleic acid hybridization properties and molecular modelling studies of conformationally restricted 3'-O,4'-C-methylene-linked alpha-L-ribonucleotides.
Carbohydrate research 2006;341(10):1398-407.
2006: Kaur Harleen; Arora Amit; Wengel Jesper; Maiti Souvik
Thermodynamic, counterion, and hydration effects for the incorporation of locked nucleic acid nucleotides into DNA duplexes.
Biochemistry 2006;45(23):7347-55.
2006: Kalra Neerja; Parlato Maria C; Parmar Virinder S; Wengel Jesper
DNA and LNA oligonucleotides containing N2'-functionalised derivatives of 2'-amino-2'-deoxyuridine.
Bioorganic & medicinal chemistry letters 2006;16(12):3166-9.
2006: Kumar T Santhosh; Madsen Andreas S; Wengel Jesper; Hrdlicka Patrick J
Synthesis and hybridization studies of 2'-amino-alpha-L-LNA and tetracyclic "locked LNA".
The Journal of organic chemistry 2006;71(11):4188-201.
2006: Lindegaard Dorthe; Wood David O; Wengel Jesper; Lee Jeremy S
Electron injection from the side of an M-DNA duplex.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2006;11(1):82-7.
2006: Vester Birte; Hansen Lykke H; Lundberg Lars Bo; Babu B Ravindra; Sørensen Mads D; Wengel Jesper; Douthwaite Stephen
Locked nucleoside analogues expand the potential of DNAzymes to cleave structured RNA targets.
BMC molecular biology 2006;7():19.
2005: Hrdlicka Patrick J; Babu B Ravindra; Sørensen Mads D; Harrit Niels; Wengel Jesper
Multilabeled pyrene-functionalized 2'-amino-LNA probes for nucleic acid detection in homogeneous fluorescence assays.
Journal of the American Chemical Society 2005;127(38):13293-9.
2005: Hrdlicka Patrick J; Kumar T Santhosh; Wengel Jesper
Targeting of mixed sequence double-stranded DNA using pyrene-functionalized 2'-amino-alpha-l-LNA.
Chemical communications (Cambridge, England) 2005;(34):4279-81.
2005: Filichev Vyacheslav V; Vester Birte; Hansen Lykke H; Abdel Aal Mohammed T; Babu B Ravindra; Wengel Jesper; Pedersen Erik B
Enhanced inhibition of transcription start by targeting with 2'-OMe pentaribonucleotides comprising locked nucleic acids and intercalating nucleic acids.
Chembiochem : a European journal of chemical biology 2005;6(7):1181-4.
2005: Brunet Erika; Alberti Patrizia; Perrouault Loïc; Babu Ravindra; Wengel Jesper; Giovannangeli Carine
Exploring cellular activity of locked nucleic acid-modified triplex-forming oligonucleotides and defining its molecular basis.
The Journal of biological chemistry 2005;280(20):20076-85.
2005: Babu B Ravindra; Hrdlicka Patrick J; McKenzie Christine J; Wengel Jesper
Optimized DNA targeting using N,N-bis(2-pyridylmethyl)-beta-alanyl 2'-amino-LNA.
Chemical communications (Cambridge, England) 2005;(13):1705-7.
2005: Hrdlicka Patrick J; Andersen Nicolai K; Jepsen Jan S; Hansen Flemming G; Haselmann Kim F; Nielsen Claus; Wengel Jesper
Synthesis and biological evaluation of branched and conformationally restricted analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd).
Bioorganic & medicinal chemistry 2005;13(7):2597-621.
2005: Hrdlicka Patrick J; Jepsen Jan S; Nielsen Claus; Wengel Jesper
Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd).
Bioorganic & medicinal chemistry 2005;13(4):1249-60.
2005: Raunkjaer Michael; Sørensen Mads D; Wengel Jesper
Synthesis and thermal denaturation studies of novel 2'-O,3'-C-linked bicyclic oligonucleotides with a methoxy or a piperazino group facing the major groove of nucleic acid duplexes.
Organic & biomolecular chemistry 2005;3(1):130-5.
2005: Hrdlicka Patrick J; Kumar T Santhosh; Wengel Jesper
Synthesis of a 2'-amino-alpha-1-LNA-T phosphoramidite.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):1101-4.
2005: Lindegaard Dorthe; Babu B Ravindra; Wengel Jesper
DNA self-assembling systems: branched oligonucleotides as building blocks and monitoring by pyrene excimer band formation.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):679-81.
2005: Hrdlicka Patrick J; Jepsen Jan S; Wengel Jesper
Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd).
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):397-400.
2005: Brunet Erika; Corgnali Maddalena; Perrouault Loïc; Roig Victoria; Asseline Ulysse; Sørensen Mads D; Babu B Ravindra; Wengel Jesper; Giovannangeli Carine
Intercalator conjugates of pyrimidine locked nucleic acid-modified triplex-forming oligonucleotides: improving DNA binding properties and reaching cellular activities.
Nucleic acids research 2005;33(13):4223-34.
2005: Pfundheller Henrik M; Sørensen Anders M; Lomholt Christian; Johansen Anders M; Koch Troels; Wengel Jesper
Locked nucleic acid synthesis.
Methods in molecular biology (Clifton, N.J.) 2005;288():127-46.
2004: Filichev Vyacheslav V; Christensen Ulf B; Pedersen Erik B; Babu B Ravindra; Wengel Jesper
Locked nucleic acids and intercalating nucleic acids in the design of easily denaturing nucleic acids: thermal stability studies.
Chembiochem : a European journal of chemical biology 2004;5(12):1673-9.
2004: Vester Birte; Wengel Jesper
LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA.
Biochemistry 2004;43(42):13233-41.
2004: Kalra Neerja; Babu B Ravindra; Parmar Virinder S; Wengel Jesper
Conformationally controlled high-affinity targeting of RNA or DNA by novel 2'-amino-DNA/LNA mixmers and pyrenyl-functionalized 2'-amino-DNA.
Organic & biomolecular chemistry 2004;2(20):2885-7.
2004: Meldgaard Michael; Hansen Flemming Gundorph; Wengel Jesper
3'-C-Branched LNA-type nucleosides locked in an N-type furanose ring conformation: synthesis, incorporation into oligodeoxynucleotides, and hybridization studies.
The Journal of organic chemistry 2004;69(19):6310-22.
2004: Hrdlicka Patrick J; Babu B Ravindra; Sørensen Mads D; Wengel Jesper
Interstrand communication between 2'-N-(pyren-1-yl)methyl-2'-amino-LNA monomers in nucleic acid duplexes: directional control and signalling of full complementarity.
Chemical communications (Cambridge, England) 2004;(13):1478-9.
2004: Nielsen Katrine E; Rasmussen Jill; Kumar Ravindra; Wengel Jesper; Jacobsen Jens Peter; Petersen Michael
NMR studies of fully modified locked nucleic acid (LNA) hybrids: solution structure of an LNA:RNA hybrid and characterization of an LNA:DNA hybrid.
Bioconjugate chemistry 2004;15(3):449-57.
2004: Bryld Torsten; Hojland Torben; Wengel Jesper
DNA-selective hybridization and dual strand invasion of short double-stranded DNA using pyren-1-ylcarbonyl-functionalized 4'-C-piperazinomethyl-DNA.
Chemical communications (Cambridge, England) 2004;(9):1064-5.
2004: Sun Bei-Wen; Babu B Ravindra; Sørensen Mads D; Zakrzewska Krystyna; Wengel Jesper; Sun Jian-Sheng
Sequence and pH effects of LNA-containing triple helix-forming oligonucleotides: physical chemistry, biochemistry, and modeling studies.
Biochemistry 2004;43(14):4160-9.
2004: Jepsen Jan Stenvang; Wengel Jesper
LNA-antisense rivals siRNA for gene silencing.
Current opinion in drug discovery & development 2004;7(2):188-94.
2004: Vester B; Lundberg L B; Sørensen M D; Babu B R; Douthwaite S; Wengel J
Improved RNA cleavage by LNAzyme derivatives of DNAzymes.
Biochemical Society transactions 2004;32(Pt 1):37-40.
2004: Wengel Jesper
Nucleic acid nanotechnology-towards Angstrom-scale engineering.
Organic & biomolecular chemistry 2004;2(3):277-80.
2004: Christensen Nanna K; Bryld Torsten; Sørensen Mads D; Arar Khalil; Wengel Jesper; Nielsen Poul
Parallel nucleic acid recognition by the LNA (locked nucleic acid) stereoisomers beta-L-LNA and alpha-D-LNA; studies in the mirror image world.
Chemical communications (Cambridge, England) 2004;(3):282-3.
2004: Raunak; Ravindra Babu B; Sørensen Mads D; Parmar Virinder S; Harrit Niels H; Wengel Jesper
Oligodeoxynucleotides containing alpha-L-ribo configured LNA-type C-aryl nucleotides.
Organic & biomolecular chemistry 2004;2(1):80-9.
2004: Jepsen Jan Stenvang; Sørensen Mads D; Wengel Jesper
Locked nucleic acid: a potent nucleic acid analog in therapeutics and biotechnology.
Oligonucleotides 2004;14(2):130-46.
2004: Crinelli Rita; Bianchi Marzia; Gentilini Lucia; Palma Linda; Sørensen Mads D; Bryld Torsten; Babu Ravindra B; Arar Khalil; Wengel Jesper; Magnani Mauro
Transcription factor decoy oligonucleotides modified with locked nucleic acids: an in vitro study to reconcile biostability with binding affinity.
Nucleic acids research 2004;32(6):1874-85.
2003: Babu B Ravindra; Keinicke Lise; Petersen Michael; Nielsen Claus; Wengel Jesper
2'-Spiro ribo- and arabinonucleosides: synthesis, molecular modelling and incorporation into oligodeoxynucleotides.
Organic & biomolecular chemistry 2003;1(20):3514-26.
2003: Sørensen Mads D; Petersen Michael; Wengel Jesper
Functionalized LNA (locked nucleic acid): high-affinity hybridization of oligonucleotides containing N-acylated and N-alkylated 2'-amino-LNA monomers.
Chemical communications (Cambridge, England) 2003;(17):2130-1.
2003: Raunkjaer Michael; Bryld Torsten; Wengel Jesper
N-methylpiperazinocarbonyl-2',3'-BcNA and 4'-C-(N-methylpiperazino)methyl-DNA: introduction of basic functionalities facing the major groove and the minor groove of a DNA:DNA duplex.
Chemical communications (Cambridge, England) 2003;(13):1604-5.
2003: Poopeiko Nicolai E; Juhl Martin; Vester Birte; Sørensen Mads D; Wengel Jesper
Xylo-Configured oligonucleotides (XNA, xylo nucleic acid): synthesis of conformationally restricted derivatives and hybridization towards DNA and RNA complements.
Bioorganic & medicinal chemistry letters 2003;13(14):2285-90.
2003: Petersen Michael; Nielsen Jakob T; Bondensgaard Kent; Wengel Jesper; Jacobsen Jens Peter
Structural characterization of LNA and alpha-L-LNA hybridized to RNA.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1691-3.
2003: Babu B Ravindra; Wengel Jesper
Aryl-beta-C-LNA monomers as universal hybridization probes.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1317-9.
2003: Babu B Ravindra; Keinicke Lise; Wengel Jesper
Synthesis of 2'-spiro ribo- and arabinonucleosides.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1313-5.
2003: Bryld Torsten; Wengel Jesper
Synthesis of a base-protected xylo-LNA adenine nucleoside.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1163-5.
2003: Lindegaard Dorthe; Wengel Jesper
Synthesis and hybridization properties of oligodeoxynucleotides containing 3'-deoxy-3'-C-methyleneuridine.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1159-61.
2003: Gaubert Gilles; Wengel Jesper
Synthesis of a base-protected alpha-L-LNA guanine nucleoside.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1155-7.
2003: Poopeiko Nicolai E; Dahl Britta M; Wengel Jesper
xylo-configured oligonucleotides (XNA, xylo nucleic acids): synthesis and hybridization studies.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1147-9.
2003: Christensen Signe M; Rosenbohm Christoph; Sørensen Mads; Larsen Lotte-Emilie; Wengel Jesper; Koch Troels
Improved synthesis of 2'-amino-LNA.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1131-3.
2003: Vogel Stefan; Rohr Katja; Dahl Otto; Wengel Jesper
Synthesis of an asymmetrically substituted AZA crown ether as metal and amino acid binding site in DNA conjugates.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1039-40.
2003: Wengel Jesper; Vester Birte; Lundberg Lars Bo; Douthwaite Stephen; Sørensen Mads D; Babu B Ravindra; Gait Michael J; Arzumanov Andrey; Petersen Michael; Nielsen Jakob T
LNA and alpha-L-LNA: towards therapeutic applications.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):601-4.
2003: Tømmerholt Henning V; Christensen Nanna K; Nielsen Poul; Wengel Jesper; Stein Paul C; Jacobsen Jens Peter; Petersen Michael
NMR solution structure of dsDNA containing a bicyclic D-arabino-configured nucleotide fixed in an O4'-endo sugar conformation.
Organic & biomolecular chemistry 2003;1(10):1790-7.
2003: Vogel Stefan; Rohr Katja; Dahl Otto; Wengel Jesper
A substituted triaza crown ether as a binding site in DNA conjugates.
Chemical communications (Cambridge, England) 2003;(8):1006-7.
2003: Rosenbohm Christoph; Christensen Signe M; Sørensen Mads D; Pedersen Daniel Sejer; Larsen Lotte-Emilie; Wengel Jesper; Koch Troels
Synthesis of 2'-amino-LNA: a new strategy.
Organic & biomolecular chemistry 2003;1(4):655-63.
2003: Petersen Michael; Wengel Jesper
LNA: a versatile tool for therapeutics and genomics.
Trends in biotechnology 2003;21(2):74-81.
2003: Lauritsen Anne; Dahl Britta M; Dahl Otto; Vester Birte; Wengel Jesper
Methylphosphonate LNA: a locked nucleic acid with a methylphosphonate linkage.
Bioorganic & medicinal chemistry letters 2003;13(2):253-6.
2003: Arzumanov Andrey; Stetsenko Dmitry A; Malakhov Andrey D; Reichelt Stefanie; Sørensen Mads D; Babu B Ravindra; Wengel Jesper; Gait Michael J
A structure-activity study of the inhibition of HIV-1 Tat-dependent trans-activation by mixmer 2'-O-methyl oligoribonucleotides containing locked nucleic acid (LNA), alpha-L-LNA, or 2'-thio-LNA residues.
Oligonucleotides 2003;13(6):435-53.
2002: Vester Birte; Lundberg Lars Bo; Sørensen Mads D; Babu B Ravindra; Douthwaite Stephen; Wengel Jesper
LNAzymes: incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage.
Journal of the American Chemical Society 2002;124(46):13682-3.
2002: Thomasen Helena; Meldgaard Michael; Freitag Morten; Petersen Michael; Wengel Jesper; Nielsen Poul
3',4'-trans-linked bicyclic nucleosides locked in S-type conformations.
Chemical communications (Cambridge, England) 2002;(17):1888-9.
2002: Nielsen Katrine M Ellemann; Petersen Michael; Håkansson Anders E; Wengel Jesper; Jacobsen Jens Peter
alpha-L-LNA (alpha-L-ribo configured locked nucleic acid) recognition of DNA: an NMR spectroscopic study.
Chemistry (Weinheim an der Bergstrasse, Germany) 2002;8(13):3001-9.
2002: Petersen Michael; Bondensgaard Kent; Wengel Jesper; Jacobsen Jens Peter
Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids.
Journal of the American Chemical Society 2002;124(21):5974-82.
2002: Lauritsen Anne; Wengel Jesper
Oligodeoxynucleotides containing amide-linked LNA-type dinucleotides: synthesis and high-affinity nucleic acid hybridization.
Chemical communications (Cambridge, England) 2002;(5):530-1.
2002: Sørensen Mads D; Kvaernø Lisbet; Bryld Torsten; Håkansson Anders E; Verbeure Birgit; Gaubert Gilles; Herdewijn Piet; Wengel Jesper
alpha-L-ribo-configured locked nucleic acid (alpha-L-LNA): synthesis and properties.
Journal of the American Chemical Society 2002;124(10):2164-76.
2002: Keinicke Lise; Sørensen Mads D; Wengel Jesper
Alpha-L-RNA (alpha-L-ribo configured RNA): synthesis and RNA-selective hybridization of alpha-L-RNA/alpha-L-LNA chimera.
Bioorganic & medicinal chemistry letters 2002;12(4):593-6.
2001: Arzumanov A; Walsh A P; Rajwanshi V K; Kumar R; Wengel J; Gait M J
Inhibition of HIV-1 Tat-dependent trans activation by steric block chimeric 2'-O-methyl/LNA oligoribonucleotides.
Biochemistry 2001;40(48):14645-54.
2001: Babu B R; Wengel J
Universal hybridization using LNA (locked nucleic acid) containing a novel pyrene LNA nucleotide monomer.
Chemical communications (Cambridge, England) 2001;(20):2114-5.
2001: Kvaernø L; Wengel J
Novel bicyclic nucleoside analogue (1S,5S,6S)-6- hydroxy-5-hydroxymethyl-1-(uracil-1-yl)-3,8-dioxabicyclo[3.2.1]octane: synthesis and incorporation into oligodeoxynucleotides.
The Journal of organic chemistry 2001;66(16):5498-503.
2001: Petersen M; Håkansson A E; Wengel J; Jacobsen J P
alpha-L-LNA (alpha-I-ribo configured locked nucleic acid) recognition of RNA. A study by NMR spectroscopy and molecular dynamics simulations.
Journal of the American Chemical Society 2001;123(30):7431-2.
2001: Kvaernø L; Wightman R H; Wengel J
Synthesis of a novel bicyclic nucleoside restricted to an S-type conformation and initial evaluation of its hybridization properties when incorporated into oligodeoxynucleotides.
The Journal of organic chemistry 2001;66(15):5106-12.
2001: Arzumanov A; Walsh A P; Liu X; Rajwanshi V K; Wengel J; Gait M J
Oligonucleotide analogue interference with the HIV-1 Tat protein-TAR RNA interaction.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):471-80.
2001: Wengel J; Petersen M; Nielsen K E; Jensen G A; Håkansson A E; Kumar R; Sørensen M D; Rajwanshi V K; Bryld T; Jacobsen J P
LNA (locked nucleic acid) and the diastereoisomeric alpha-L-LNA: conformational tuning and high-affinity recognition of DNA/RNA targets.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):389-96.
2001: Håkansson A E; Wengel J
The adenine derivative of alpha-L-LNA (alpha-L-ribo configured locked nucleic acid): synthesis and high-affinity hybridization towards DNA, RNA, LNA and alpha-L-LNA complementary sequences.
Bioorganic & medicinal chemistry letters 2001;11(7):935-8.
2001: Christensen U; Jacobsen N; Rajwanshi V K; Wengel J; Koch T
Stopped-flow kinetics of locked nucleic acid (LNA)-oligonucleotide duplex formation: studies of LNA-DNA and DNA-DNA interactions.
The Biochemical journal 2001;354(Pt 3):481-4.
2001: Sørensen M D; Kvaernø L; Bryld T; Håkansson A E; Keinicke L; Verbeure B; Herdewijn P; Wengel J
The alpha-L-ribo-isomers of RNA and LNA (locked nucleic acid).
Nucleic acids research. Supplement (2001) 2001;(1):25-6.
2000: Jørgensen L B; Nielsen P; Wengel J; Jacobsen J P
The solution structure of a DNA duplex containing a single 1-(2-O,3-C-ethylene-beta-D-arabinofuranosyl)thymidine nucleoside.
Journal of biomolecular structure & dynamics 2000;18(1):45-57.
2000: Kvaernø L; Kumar R; Dahl B M; Olsen C E; Wengel J
Synthesis of abasic locked nucleic acid and two seco-LNA derivatives and evaluation of their hybridization properties compared with their more flexible DNA counterparts.
The Journal of organic chemistry 2000;65(17):5167-76.
2000: Bondensgaard K; Petersen M; Singh S K; Rajwanshi V K; Kumar R; Wengel J; Jacobsen J P
Structural studies of LNA:RNA duplexes by NMR: conformations and implications for RNase H activity.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(15):2687-95.
2000: Sørensen M D; Meldgaard M; Raunkjaer M; Rajwanshi V K; Wengel J
Branched oligonucleotides containing bicyclic nucleotides as branching points and DNA or LNA as triplex forming branch.
Bioorganic & medicinal chemistry letters 2000;10(16):1853-6.
2000: Nielsen K E; Singh S K; Wengel J; Jacobsen J P
Solution structure of an LNA hybridized to DNA: NMR study of the d(CT(L)GCT(L)T(L)CT(L)GC):d(GCAGAAGCAG) duplex containing four locked nucleotides.
Bioconjugate chemistry 2000;11(2):228-38.
2000: Petersen M; Nielsen C B; Nielsen K E; Jensen G A; Bondensgaard K; Singh S K; Rajwanshi V K; Koshkin A A; Dahl B M; Wengel J; Jacobsen J P
The conformations of locked nucleic acids (LNA).
Journal of molecular recognition : JMR 2000;13(1):44-53.
1999: Nielsen C B; Singh S K; Wengel J; Jacobsen J P
The solution structure of a locked nucleic acid (LNA) hybridized to DNA.
Journal of biomolecular structure & dynamics 1999;17(2):175-91.
1999: Pfundheller H M; Koshkin A A; Olsen C E; Wengel J
Evaluation of oligonucleotides containing two novel 2'-O-methyl modified nucleotide monomers: a 3'-C-allyl and a 2'-O,3'-C-linked bicyclic derivative.
Nucleosides & nucleotides 1999;18(9):2017-30.
1999: Pfundheller H M; Wengel J
Oligonucleotides containing 4'-C-aminomethyl-2'-modified thymidines show increased binding affinity towards DNA and RNA.
Bioorganic & medicinal chemistry letters 1999;9(18):2667-72.
1998: Kumar R; Singh S K; Koshkin A A; Rajwanshi V K; Meldgaard M; Wengel J
The first analogues of LNA (locked nucleic acids): phosphorothioate-LNA and 2'-thio-LNA.
Bioorganic & medicinal chemistry letters 1998;8(16):2219-22.

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