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Mark Wentland

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TOP 3
Melissa A VanAlstine; Mark P Wentland; Juan Alvarez; Qing Cao; Dana J Cohen; Brian I Knapp; Jean M Bidlack
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 9: Synthesis, characterization and molecular modeling of pyridinyl isosteres of N-BPE-8-CAC (1), a high affinity ligand for opioid receptors.
Mark P Wentland; Dana J Cohen; Joseph M Gargano; Sunjin Jo; Melissa A VanAlstine; Jean M Bidlack
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar Ki range: oxygenated N-(2-[1,1'-biphenyl]-4-ylethyl) analogues of 8-CAC.
Donald C Porter; Anatoliy T Puzyrev; Rebecca Rokow-Kittell; Gary P Schools; Jun Shi; Mark P Wentland; Deborah K West; Serena Altilia; Phil S Baran; Eugenia Broude; Bey-Dih Chang; Mengqian Chen; Elena Farmaki; Lawrence T Friedhoff; Balazs Gyorffy; Gregory Hurteau; Swathi Kalurupalle; Hippokratis Kiaris; Chang-uk Lim; Athanasios G Papavassiliou; Igor B Roninson
Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.

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All Publications

2013: Melissa A VanAlstine; Mark P Wentland; Juan Alvarez; Qing Cao; Dana J Cohen; Brian I Knapp; Jean M Bidlack
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 9: Synthesis, characterization and molecular modeling of pyridinyl isosteres of N-BPE-8-CAC (1), a high affinity ligand for opioid receptors.
Bioorganic & medicinal chemistry letters 2013;23(7):2128-33.
2012: Mark P Wentland; Dana J Cohen; Joseph M Gargano; Sunjin Jo; Melissa A VanAlstine; Jean M Bidlack
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar Ki range: oxygenated N-(2-[1,1'-biphenyl]-4-ylethyl) analogues of 8-CAC.
Bioorganic & medicinal chemistry letters 2012;22(24):7340-4.
2012: Donald C Porter; Anatoliy T Puzyrev; Rebecca Rokow-Kittell; Gary P Schools; Jun Shi; Mark P Wentland; Deborah K West; Serena Altilia; Phil S Baran; Eugenia Broude; Bey-Dih Chang; Mengqian Chen; Elena Farmaki; Lawrence T Friedhoff; Balazs Gyorffy; Gregory Hurteau; Swathi Kalurupalle; Hippokratis Kiaris; Chang-uk Lim; Athanasios G Papavassiliou; Igor B Roninson
Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(34):13799-804.
2011: Lindsay B Hough; Julia W Nalwalk; Jun Yang; Jennie L Conroy; Melissa A VanAlstine; Weizhu Yang; Joseph Gargano; Zhixing Shan; Shao-Zhong Zhang; Mark P Wentland; James G Phillips; Brian I Knapp; Jean M Bidlack; Obbe P Zuiderveld; Rob Leurs; Xinxin Ding
Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic.
Pain 2011;152(4):878-87.
2010: Jennie L Conroy; Cheng Fang; Jun Gu; Scott O Zeitlin; Weizhu Yang; Jun Yang; Melissa A VanAlstine; Julia W Nalwalk; Phillip J Albrecht; Joseph E Mazurkiewicz; Abigail Snyder-Keller; Zhixing Shan; Shao-Zhong Zhang; Mark P Wentland; Melissa Behr; Brian I Knapp; Jean M Bidlack; Obbe P Zuiderveld; Rob Leurs; Xinxin Ding; Lindsay B Hough
Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling.
Nature neuroscience 2010;13(3):284-6.
2009: Mark P Wentland; Rongliang Lou; Qun Lu; Yigong Bu; Christoph Denhardt; Jin Jin; Rakesh Ganorkar; Melissa A VanAlstine; Chengyun Guo; Dana J Cohen; Jean M Bidlack
Syntheses of novel high affinity ligands for opioid receptors.
Bioorganic & medicinal chemistry letters 2009;19(8):2289-94.
2009: Mark P Wentland; Qun Lu; Rakesh Ganorkar; Shao-Zhong Zhang; Sunjin Jo; Dana J Cohen; Jean M Bidlack
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 7: syntheses and opioid receptor properties of cyclic variants of cyclazocine.
Bioorganic & medicinal chemistry letters 2009;19(2):365-8.
2009: Mark P Wentland; Rongliang Lou; Qun Lu; Yigong Bu; Melissa A VanAlstine; Dana J Cohen; Jean M Bidlack
Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.
Bioorganic & medicinal chemistry letters 2009;19(1):203-8.
2008: Mark P Wentland; Xufeng Sun; Dana J Cohen; Jean M Bidlack
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-carboxamidocyclazocine.
Bioorganic & medicinal chemistry 2008;16(10):5653-64.
2007: Melissa A VanAlstine; Mark P Wentland; Dana J Cohen; Jean M Bidlack
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4'-phenyl)-phenethyl) analogues of 8-CAC.
Bioorganic & medicinal chemistry letters 2007;17(23):6516-20.
2007: Neal C Gehani; Julia W Nalwalk; Raj K Razdan; Billy R Martin; Xufung Sun; Mark P Wentland; Mary E Abood; Lindsay B Hough
Significance of cannabinoid CB1 receptors in improgan antinociception.
The journal of pain : official journal of the American Pain Society 2007;8(11):850-60.
2007: Lindsay B Hough; Julia W Nalwalk; James G Phillips; Brian Kern; Zhixing Shan; Mark P Wentland; Iwan J P De Esch; Elwin Janssen; Travis Barr; Rebecca Stadel
CC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist.
Neuropharmacology 2007;52(5):1244-55.
2006: Mark P Wentland; Melissa VanAlstine; Robert Kucejko; Rongliang Lou; Dana J Cohen; Amy L Parkhill; Jean M Bidlack
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 4. Opioid receptor binding properties of 8-[N-(4'-phenyl)-phenethyl)carboxamido] analogues of cyclazocine and ethylketocycalzocine.
Journal of medicinal chemistry 2006;49(18):5635-9.
2005: Lindsay B Hough; Julia W Nalwalk; Qun Lu; Zhixing Shan; Konstantina Svokos; Mark P Wentland; M José Montero
Antinociceptive, brain-penetrating derivatives related to improgan, a non-opioid analgesic.
European journal of pharmacology 2005;522(1-3):38-46.
2005: Mark P Wentland; Xufeng Sun; Yigong Bu; Rongliang Lou; Dana J Cohen; Jean M Bidlack
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 3: 8-Thiocarboxamido and 8-thioformamido derivatives of cyclazocine.
Bioorganic & medicinal chemistry letters 2005;15(10):2547-51.
2005: Mark P Wentland; Qun Lu; Rongliang Lou; Yigong Bu; Brian I Knapp; Jean M Bidlack
Synthesis and opioid receptor binding properties of a highly potent 4-hydroxy analogue of naltrexone.
Bioorganic & medicinal chemistry letters 2005;15(8):2107-10.
2004: Glenn W Stevenson; Mark P Wentland; Jean M Bidlack; Nancy K Mello; S Stevens Negus
Effects of the mixed-action kappa/mu opioid agonist 8-carboxamidocyclazocine on cocaine- and food-maintained responding in rhesus monkeys.
European journal of pharmacology 2004;506(2):133-41.
2004: Genya Gekker; Shuxian Hu; Mark P Wentland; Jean M Bidlack; James R Lokensgard; Phillip K Peterson
Kappa-opioid receptor ligands inhibit cocaine-induced HIV-1 expression in microglial cells.
The Journal of pharmacology and experimental therapeutics 2004;309(2):600-6.
2004: Ao Zhang; Wennan Xiong; Jean M Bidlack; James E Hilbert; Brian I Knapp; Mark P Wentland; John L Neumeyer
10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors.
Journal of medicinal chemistry 2004;47(1):165-74.
2003: Qun Zhou; Wen-hu Duan; Dana J Cohen; Jean M Bidlack; Mark P Wentland
Synthesis and pharmacology of 8-amino-3-[(tetrahydro-2-furanyl)methyl] benzomorphan.
Yao xue xue bao = Acta pharmaceutica Sinica 2003;38(10):748-53.
2003: Mark P Wentland; Xufeng Sun; Yingchun Ye; Rongliang Lou; Jean M Bidlack
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 2: 8-formamidocyclazocine analogues.
Bioorganic & medicinal chemistry letters 2003;13(11):1911-4.
2003: Mark P Wentland; Yingchun Ye; Christopher L Cioffi; Rongliang Lou; Qun Zhou; Guoyou Xu; Wenhu Duan; Christoph M Dehnhardt; Xufeng Sun; Dana J Cohen; Jean M Bidlack
Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines.
Journal of medicinal chemistry 2003;46(5):838-49.
2002: Balanehru Subramanian; Alexander Nakeff; Joseph Media; Mark P Wentland; Frederick A Valeriote
Cellular drug action profile paradigm applied to XK469.
Journal of experimental therapeutics & oncology 2002;2(5):253-63.
2002: Jean M Bidlack; Dana J Cohen; Jay P McLaughlin; Rongliang Lou; Yingchun Ye; Mark P Wentland
8-Carboxamidocyclazocine: a long-acting, novel benzomorphan.
The Journal of pharmacology and experimental therapeutics 2002;302(1):374-80.
2001: Mark P Wentland; Rongliang Lou; C M Dehnhardt; Wenhu Duan; Dana J Cohen; Jean M Bidlack
3-Carboxamido analogues of morphine and naltrexone. synthesis and opioid receptor binding properties.
Bioorganic & medicinal chemistry letters 2001;11(13):1717-21.
2001: Mark P Wentland; Rongliang Lou; Yingchun Ye; Dana J Cohen; G P Richardson; Jean M Bidlack
8-Carboxamidocyclazocine analogues: redefining the structure-activity relationships of 2,6-methano-3-benzazocines.
Bioorganic & medicinal chemistry letters 2001;11(5):623-6.
2000: Mark P Wentland; Wenhu Duan; Dana J Cohen; Jean M Bidlack
Selective protection and functionalization of morphine: synthesis and opioid receptor binding properties of 3-amino-3-desoxymorphine derivatives.
Journal of medicinal chemistry 2000;43(19):3558-65.
2000: Mark P Wentland; G Xu; C L Cioffi; Yingchun Ye; Wenhu Duan; Dana J Cohen; A M Colasurdo; Jean M Bidlack
8-Aminocyclazocine analogues: synthesis and structure-activity relationships.
Bioorganic & medicinal chemistry letters 2000;10(2):183-7.
2000: Lindsay B Hough; Julia W Nalwalk; W G Barnes; Rob Leurs; Wiro M P B Menge; Henk Timmerman; Mark P Wentland
A third life for burimamide. Discovery and characterization of a novel class of non-opioid analgesics derived from histamine antagonists.
Annals of the New York Academy of Sciences 2000;909():25-40.
2000: Jean M Bidlack; Jay P McLaughlin; Mark P Wentland
Partial opioids. Medications for the treatment of pain and drug abuse.
Annals of the New York Academy of Sciences 2000;909():1-11.
1997: Lindsay B Hough; Julia W Nalwalk; B Y Li; Rob Leurs; Wiro M P B Menge; Henk Timmerman; M E Carlile; C Cioffi; Mark P Wentland
Novel qualitative structure-activity relationships for the antinociceptive actions of H2 antagonists, H3 antagonists and derivatives.
The Journal of pharmacology and experimental therapeutics 1997;283(3):1534-43.