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Philip Wenzel

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Drug Tolerance

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Hanke Mollnau; Thomas Münzel; Matthias Oelze; Eberhard Schulz; Christine Teutsch; Philip Wenzel; Zhixiong Wu; Elena Zinßius; Carolyn Foster; Jasmin Ghaemi Kerahrodi; Michael Hausding; Thomas Jansen; Maike Knorr; Swenja Kröller-Schön; Huige Li; Andreas Daiber
Effects of telmisartan or amlodipine monotherapy versus telmisartan/amlodipine combination therapy on vascular dysfunction and oxidative stress in diabetic rats.
Swenja Kröller-Schön; Thomas Münzel; Matthias Oelze; Richard Schell; Alexander Scholz; Alexandra Schuff; Eberhard Schulz; Stephan Sudowe; Philip Wenzel; Steffen Daub; Tommaso Gori; Stephan Grabbe; Michael Hausding; Susanne Karbach; Thomas Klein; Maike Knorr; Sabine Kossmann; Andreas Daiber
Glucose-independent improvement of vascular dysfunction in experimental sepsis by dipeptidyl-peptidase 4 inhibition.
Swenja Kröller-Schön; Thomas Münzel; Matthias Oelze; Andrea Schüler; Andreas Daiber; Felix Hauptmann; Michael Hausding; Tjebo Heeren; Thomas Jansen; John F Keaney; Benoit Viollet; Philip Wenzel; Eberhard Schulz
α1AMP-activated protein kinase mediates vascular protective effects of exercise.

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All Publications

2013: Hanke Mollnau; Thomas Münzel; Matthias Oelze; Eberhard Schulz; Christine Teutsch; Philip Wenzel; Zhixiong Wu; Elena Zinßius; Carolyn Foster; Jasmin Ghaemi Kerahrodi; Michael Hausding; Thomas Jansen; Maike Knorr; Swenja Kröller-Schön; Huige Li; Andreas Daiber
Effects of telmisartan or amlodipine monotherapy versus telmisartan/amlodipine combination therapy on vascular dysfunction and oxidative stress in diabetic rats.
Naunyn-Schmiedeberg's archives of pharmacology 2013;386(5):405-19.
2012: Swenja Kröller-Schön; Thomas Münzel; Matthias Oelze; Richard Schell; Alexander Scholz; Alexandra Schuff; Eberhard Schulz; Stephan Sudowe; Philip Wenzel; Steffen Daub; Tommaso Gori; Stephan Grabbe; Michael Hausding; Susanne Karbach; Thomas Klein; Maike Knorr; Sabine Kossmann; Andreas Daiber
Glucose-independent improvement of vascular dysfunction in experimental sepsis by dipeptidyl-peptidase 4 inhibition.
Cardiovascular research 2012;96(1):140-9.
2012: Swenja Kröller-Schön; Thomas Münzel; Matthias Oelze; Andrea Schüler; Andreas Daiber; Felix Hauptmann; Michael Hausding; Tjebo Heeren; Thomas Jansen; John F Keaney; Benoit Viollet; Philip Wenzel; Eberhard Schulz
α1AMP-activated protein kinase mediates vascular protective effects of exercise.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(7):1632-41.
2012: Maike Knorr; Swenja Kröller-Schön; Thomas Münzel; Matthias Oelze; Robert Rümmler; Dirk Sartor; Armin Scherhag; Jörg Schreiner; Alexandra Schuff; Eberhard Schulz; Philip Wenzel; Karl Burgin; Steffen Daub; Tommaso Gori; Michael Hausding; Andreas Daiber
Characterization of new organic nitrate hybrid drugs covalently bound to valsartan and cilostazol.
Pharmacology 2012;90(3-4):193-204.
2012: Andreas Daiber; Matthias Oelze; Andrea Pautz; Philip Wenzel; Franziska Bollmann; Hartmut Kleinert
Heme oxygenase-1 induction and organic nitrate therapy: beneficial effects on endothelial dysfunction, nitrate tolerance, and vascular oxidative stress.
International journal of hypertension 2012;2012():842632.
2011: Swenja Kröller-Schön; Andreas Daiber; Marcus Hortmann; Andrei L Kleschyov; Matthias Oelze; Thomas Renné; Eberhard Schulz; Michael Torzewski; Philip Wenzel; Thomas Münzel
Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress.
Basic research in cardiology 2011;106(6):1147-58.
2011: Swenja Schuhmacher; Eberhard Schulz; Sebastian Steven; Philip Wenzel; Franziska Bollmann; Tommaso Gori; Michael Hausding; Tjebo Heeren; Hartmut Kleinert; Maike Knorr; Thomas Münzel; Matthias Oelze; Christian Otto; Andrea Pautz; Kurt Reifenberg; Andreas Daiber
Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy.
Diabetes 2011;60(10):2608-16.
2011: Maike Knorr; Swenja Kröller-Schuhmacher; Andreas Daiber; Tommaso Gori; Michael Hausding; Tjebo Heeren; Matthias Oelze; Alexander Scholz; Eberhard Schulz; Sebastian Steven; Philip Wenzel; Thomas Münzel
Nitroglycerin-induced endothelial dysfunction and tolerance involve adverse phosphorylation and S-Glutathionylation of endothelial nitric oxide synthase: beneficial effects of therapy with the AT1 receptor blocker telmisartan.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(10):2223-31.
2011: Philip Wenzel; Nir Yogev; Matthias Oelze; Swenja Schuhmacher; Eberhard Schulz; Melanie Schwenk; Jan Stratmann; Ari Waisman; Christian Becker; Andreas Daiber; Stephan Grabbe; Michael Hausding; Helmut Jonuleit; Susanne H Karbach; Maike Knorr; Sabine Kossmann; Thomas Münzel
Lysozyme M-positive monocytes mediate angiotensin II-induced arterial hypertension and vascular dysfunction.
Circulation 2011;124(12):1370-81.
2011: Qing Lu; Ning Xia; Hui Xu; Lianjun Guo; Philip Wenzel; Andreas Daiber; Thomas Münzel; Ulrich Förstermann; Huige Li
Betulinic acid protects against cerebral ischemia-reperfusion injury in mice by reducing oxidative and nitrosative stress.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2011;24(3):132-8.
2011: Matthias Oelze; Maike Knorr; Richard Schell; Jens Kamuf; Andrea Pautz; Julia Art; Philip Wenzel; Thomas Münzel; Hartmut Kleinert; Andreas Daiber
Regulation of human mitochondrial aldehyde dehydrogenase (ALDH-2) activity by electrophiles in vitro.
The Journal of biological chemistry 2011;286(11):8893-900.
2011: Matthias Oelze; Christian Otto; Kurt Reifenberg; Swenja Schuhmacher; Eberhard Schulz; Philip Wenzel; Tjebo Heeren; Maike Knorr; Thomas Münzel; Andreas Daiber
Vascular dysfunction in streptozotocin-induced experimental diabetes strictly depends on insulin deficiency.
Journal of vascular research 2011;48(4):275-84.
2010: Thomas Jansen; Marcus Hortmann; Matthias Oelze; Benjamin Opitz; Sebastian Steven; Richard Schell; Maike Knorr; Susanne Karbach; Swenja Schuhmacher; Philip Wenzel; Thomas Münzel; Andreas Daiber
Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin.
Journal of molecular and cellular cardiology 2010;49(2):186-95.
2010: Swenja Schuhmacher; Philip Wenzel; Eberhard Schulz; Matthias Oelze; Christian Mang; Jens Kamuf; Tommaso Gori; Thomas Jansen; Maike Knorr; Susanne Karbach; Marcus Hortmann; Falk Mäthner; Aruni Bhatnagar; Ulrich Förstermann; Huige Li; Thomas Münzel; Andreas Daiber
Pentaerythritol tetranitrate improves angiotensin II-induced vascular dysfunction via induction of heme oxygenase-1.
Hypertension 2010;55(4):897-904.
2009: Philip Wenzel; Nico Abegunewardene; Thomas Münzel
Effects of selective I f-channel inhibition with ivabradine on hemodynamics in a patient with restrictive cardiomyopathy.
Clinical research in cardiology : official journal of the German Cardiac Society 2009;98(10):681-4.
2009: Philip Wenzel; Eberhard Schulz; Thomas Münzel
Protein kinase C-inhibiting properties of the losartan metabolite EXP3179 make the difference.
Hypertension 2009;54(4):707-9.
2009: S Schuhmacher; Eberhard Schulz; Matthias Oelze; A König; C Roegler; K Lange; L Sydow; T Kawamoto; Philip Wenzel; Thomas Münzel; Jochen Lehmann; Andreas Daiber
A new class of organic nitrates: investigations on bioactivation, tolerance and cross-tolerance phenomena.
British journal of pharmacology 2009;158(2):510-20.
2009: Andrea Pautz; Peter Rauschkolb; Nadine Schmidt; Julia Art; Matthias Oelze; Philip Wenzel; Ulrich Förstermann; Andreas Daiber; Hartmut Kleinert
Effects of nitroglycerin or pentaerithrityl tetranitrate treatment on the gene expression in rat hearts: evidence for cardiotoxic and cardioprotective effects.
Physiological genomics 2009;38(2):176-85.
2009: Philip Wenzel; Eberhard Schulz; Tommaso Gori; Mir Abolfazl Ostad; Falk Mäthner; Stefan Schildknecht; Sebastian Göbel; Matthias Oelze; Dirk Stalleicken; Ascan Warnholtz; Thomas Münzel; Andreas Daiber
Monitoring white blood cell mitochondrial aldehyde dehydrogenase activity: implications for nitrate therapy in humans.
The Journal of pharmacology and experimental therapeutics 2009;330(1):63-71.
2009: Mir Abolfazl Ostad; Silke Eggeling; Peter Tschentscher; Edzard Schwedhelm; Rainer H Böger; Philip Wenzel; Thomas Meinertz; Thomas Munzel; Ascan Warnholtz
Flow-mediated dilation in patients with coronary artery disease is enhanced by high dose atorvastatin compared to combined low dose atorvastatin and ezetimibe: results of the CEZAR study.
Atherosclerosis 2009;205(1):227-32.
2009: Andreas Daiber; Philip Wenzel; Matthias Oelze; S Schuhmacher; T Jansen; Thomas Münzel
Mitochondrial aldehyde dehydrogenase (ALDH-2)--maker of and marker for nitrate tolerance in response to nitroglycerin treatment.
Chemico-biological interactions 2009;178(1-3):40-7.
2009: Andreas Daiber; Matthias Oelze; Philip Wenzel; Jennifer M Dias Wickramanayake; Swenja Schuhmacher; Thomas Jansen; Karl J Lackner; Michael Torzewski; Thomas Münzel
Nitrate tolerance as a model of vascular dysfunction: roles for mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stress.
Pharmacological reports : PR 2009;61(1):33-48.
2008: Philip Wenzel; Swenja Schuhmacher; Joachim Kienhöfer; Johanna Müller; Marcus Hortmann; Matthias Oelze; Eberhard Schulz; Nicolai Treiber; Toshihiro Kawamoto; Karin Scharffetter-Kochanek; Thomas Münzel; Alexander Bürkle; Markus Bachschmid; Andreas Daiber
Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction.
Cardiovascular research 2008;80(2):280-9.
2008: Eberhard Schulz; Jörn Dopheide; Swenja Schuhmacher; Shane R Thomas; Kai Chen; Andreas Daiber; Philip Wenzel; Thomas Münzel; John F Keaney
Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction.
Circulation 2008;118(13):1347-57.
2008: Philip Wenzel; Eberhard Schulz; Matthias Oelze; Johanna Müller; Swenja Schuhmacher; Mohamed S S Alhamdani; Johannes Debrezion; Marcus Hortmann; Kurt Reifenberg; Ingrid Fleming; Thomas Münzel; Andreas Daiber
AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats.
Free radical biology & medicine 2008;45(5):619-26.
2008: Philip Wenzel; Hanke Mollnau; Matthias Oelze; Eberhard Schulz; Jennifer M Dias Wickramanayake; Johanna Müller; Swenja Schuhmacher; Marcus Hortmann; Stephan Baldus; Tommaso Gori; Ralf P Brandes; Thomas Münzel; Andreas Daiber
First evidence for a crosstalk between mitochondrial and NADPH oxidase-derived reactive oxygen species in nitroglycerin-triggered vascular dysfunction.
Antioxidants & redox signaling 2008;10(8):1435-47.
2008: Alexander Jabs; Sebastian Göbel; Philip Wenzel; Andrei L Kleschyov; Marcus Hortmann; Matthias Oelze; Andreas Daiber; Thomas Münzel
Sirolimus-induced vascular dysfunction. Increased mitochondrial and nicotinamide adenosine dinucleotide phosphate oxidase-dependent superoxide production and decreased vascular nitric oxide formation.
Journal of the American College of Cardiology 2008;51(22):2130-8.
2008: Philip Wenzel; Andreas Daiber; Matthias Oelze; Moritz Brandt; Ellen Closs; Jian Xu; Thomas Thum; Johann Bauersachs; Georg Ertl; Ming-Hui Zou; Ulrich Förstermann; Thomas Münzel
Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.
Atherosclerosis 2008;198(1):65-76.
2008: Philip Wenzel; Johanna Müller; Sarah Zurmeyer; Swenja Schuhmacher; Eberhard Schulz; Matthias Oelze; Andrea Pautz; Toshihiro Kawamoto; Leszek Wojnowski; Hartmut Kleinert; Thomas Münzel; Andreas Daiber
ALDH-2 deficiency increases cardiovascular oxidative stress--evidence for indirect antioxidative properties.
Biochemical and biophysical research communications 2008;367(1):137-43.
2008: Andreas Daiber; Philip Wenzel; Matthias Oelze; Thomas Münzel
New insights into bioactivation of organic nitrates, nitrate tolerance and cross-tolerance.
Clinical research in cardiology : official journal of the German Cardiac Society 2008;97(1):12-20.
2007: Ulrich Hink; Andreas Daiber; Nalan Kayhan; Jordis Trischler; Catharina Kraatz; Matthias Oelze; Hanke Mollnau; Philip Wenzel; Christian F Vahl; Kwok Ki Ho; Henry Weiner; Thomas Munzel
Oxidative inhibition of the mitochondrial aldehyde dehydrogenase promotes nitroglycerin tolerance in human blood vessels.
Journal of the American College of Cardiology 2007;50(23):2226-32.
2007: Kurt Reifenberg; Hans-Anton Lehr; Michael Torzewski; Gisela Steige; Elena Wiese; Ines Küpper; Christoph Becker; Sibylle Ott; Petra Nusser; Ken-Ichi Yamamura; Gerd Rechtsteiner; Tobias Warger; Andrea Pautz; Hartmut Kleinert; Albrecht Schmidt; Burkert Pieske; Philip Wenzel; Thomas Münzel; Jürgen Löhler
Interferon-gamma induces chronic active myocarditis and cardiomyopathy in transgenic mice.
The American journal of pathology 2007;171(2):463-72.
2007: Philip Wenzel; Matthias Oelze; Meike Coldewey; Marcus Hortmann; Andreas Seeling; Ulrich Hink; Hanke Mollnau; Dirk Stalleicken; Henry Weiner; Jochen Lehmann; Huige Li; Ulrich Förstermann; Thomas Münzel; Andreas Daiber
Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(8):1729-35.
2007: Katalin Szöcs; Bernard Lassègue; Philip Wenzel; Maria Wendt; Andreas Daiber; Matthias Oelze; Thomas Meinertz; Thomas Münzel; Stephan Baldus
Increased superoxide production in nitrate tolerance is associated with NAD(P)H oxidase and aldehyde dehydrogenase 2 downregulation.
Journal of molecular and cellular cardiology 2007;42(6):1111-8.
2007: Andrei L Kleschyov; Philip Wenzel; Thomas Munzel
Electron paramagnetic resonance (EPR) spin trapping of biological nitric oxide.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;851(1-2):12-20.
2007: Thomas Thum; Daniela Fraccarollo; Sabrina Thum; Maximilian Schultheiss; Andreas Daiber; Philip Wenzel; Thomas Munzel; Georg Ertl; Johann Bauersachs
Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(4):748-54.
2007: Thomas Münzel; Philip Wenzel; Andreas Daiber
Do we still need organic nitrates?
Journal of the American College of Cardiology 2007;49(12):1296-8.
2007: Philip Wenzel; Ulrich Hink; Matthias Oelze; A Seeling; T Isse; Kai Bruns; L Steinhoff; M Brandt; Andrei L Kleschyov; Eberhard Schulz; K Lange; Henry Weiner; Jochen Lehmann; Karl J Lackner; T Kawamoto; Thomas Münzel; Andreas Daiber
Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2-/- mice.
British journal of pharmacology 2007;150(4):526-33.
2007: Philip Wenzel; Ulrich Hink; Matthias Oelze; Swaantje Schuppan; Karin Schaeuble; Stefan Schildknecht; Kwok Ki Ho; Henry Weiner; Markus Bachschmid; Thomas Münzel; Andreas Daiber
Role of reduced lipoic acid in the redox regulation of mitochondrial aldehyde dehydrogenase (ALDH-2) activity. Implications for mitochondrial oxidative stress and nitrate tolerance.
The Journal of biological chemistry 2007;282(1):792-9.
2006: Michael August; Oliver Wingerter; Matthias Oelze; Philip Wenzel; Andrei L Kleschyov; Andreas Daiber; Alexander Mülsch; Thomas Münzel; Nikolaos B Tsilimingas
Mechanisms underlying dysfunction of carotid arteries in genetically hyperlipidemic rabbits.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2006;15(3):241-51.
2006: Matthias Oelze; Andreas Daiber; Ralf P Brandes; Marcus Hortmann; Philip Wenzel; Ulrich Hink; Eberhard Schulz; Hanke Mollnau; Alexandra von Sandersleben; Andrei L Kleschyov; Alexander Mülsch; Huige Li; Ulrich Förstermann; Thomas Münzel
Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats.
Hypertension 2006;48(4):677-84.
2006: Matthias Oelze; Ascan Warnholtz; Jörg Faulhaber; Philip Wenzel; Andrei L Kleschyov; Meike Coldewey; Ulrich Hink; Olaf Pongs; Ingrid Fleming; Sven Wassmann; Thomas Meinertz; Heimo Ehmke; Andreas Daiber; Thomas Münzel
NADPH oxidase accounts for enhanced superoxide production and impaired endothelium-dependent smooth muscle relaxation in BKbeta1-/- mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(8):1753-9.
2006: Hanke Mollnau; Philip Wenzel; Matthias Oelze; Nicolai Treiber; Andrea Pautz; Eberhard Schulz; Swenja Schuhmacher; Kurt Reifenberg; Dirk Stalleicken; Karin Scharffetter-Kochanek; Hartmut Kleinert; Thomas Münzel; Andreas Daiber
Mitochondrial oxidative stress and nitrate tolerance--comparison of nitroglycerin and pentaerithrityl tetranitrate in Mn-SOD+/- mice.
BMC cardiovascular disorders 2006;6():44.
2005: Hanke Mollnau; Matthias Oelze; Michael August; Maria Wendt; Andreas Daiber; Eberhard Schulz; Stephan Baldus; Andrei L Kleschyov; Anke Materne; Philip Wenzel; Ulrich Hink; Georg Nickenig; Ingrid Fleming; Thomas Münzel
Mechanisms of increased vascular superoxide production in an experimental model of idiopathic dilated cardiomyopathy.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(12):2554-9.
2004: Andreas Daiber; Matthias Oelze; Meike Coldewey; Markus Bachschmid; Philip Wenzel; Karsten Sydow; Maria Wendt; Andrei L Kleschyov; Dirk Stalleicken; Volker Ullrich; Alexander Mülsch; Thomas Münzel
Oxidative stress and mitochondrial aldehyde dehydrogenase activity: a comparison of pentaerythritol tetranitrate with other organic nitrates.
Molecular pharmacology 2004;66(6):1372-82.