Zena Werb

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Chou Jonathan; Provot Sylvain; Werb Zena
GATA3 in development and cancer differentiation: cells GATA have it!
Kessenbrock Kai; Krumbholz Markus; Schönermarck Ulf; Back Walter; Gross Wolfgang L; Werb Zena; Gröne Hermann-Josef; Brinkmann Volker; Jenne Dieter E
Netting neutrophils in autoimmune small-vessel vasculitis.
Lilla Jennifer N; Joshi Ravi V; Craik Charles S; Werb Zena
Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution.

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All Publications

2010: Chou Jonathan; Provot Sylvain; Werb Zena
GATA3 in development and cancer differentiation: cells GATA have it!
Journal of cellular physiology 2010;222(1):42-9.
2009: Kessenbrock Kai; Krumbholz Markus; Schönermarck Ulf; Back Walter; Gross Wolfgang L; Werb Zena; Gröne Hermann-Josef; Brinkmann Volker; Jenne Dieter E
Netting neutrophils in autoimmune small-vessel vasculitis.
Nature medicine 2009;15(6):623-5.
2009: Lilla Jennifer N; Joshi Ravi V; Craik Charles S; Werb Zena
Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution.
The Journal of biological chemistry 2009;284(20):13792-803.
2009: Bengatta Soraya; Arnould Catherine; Letavernier Emmanuel; Monge Matthieu; de Préneuf Hélène Martinan; Werb Zena; Ronco Pierre; Lelongt Brigitte
MMP9 and SCF protect from apoptosis in acute kidney injury.
Journal of the American Society of Nephrology : JASN 2009;20(4):787-97.
2008: Lu Pengfei; Werb Zena
Patterning mechanisms of branched organs.
Science (New York, N.Y.) 2008;322(5907):1506-9.
2008: Egeblad Mikala; Ewald Andrew J; Askautrud Hanne A; Truitt Morgan L; Welm Bryan E; Bainbridge Emma; Peeters George; Krummel Matthew F; Werb Zena
Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy.
Disease models & mechanisms 2008;1(2-3):155-67; discussion 165.
2008: Lu Pengfei; Ewald Andrew J; Martin Gail R; Werb Zena
Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis.
Developmental biology 2008;321(1):77-87.
2008: Riedl Julia; Crevenna Alvaro H; Kessenbrock Kai; Yu Jerry Haochen; Neukirchen Dorothee; Bista Michal; Bradke Frank; Jenne Dieter; Holak Tad A; Werb Zena; Sixt Michael; Wedlich-Soldner Roland
Lifeact: a versatile marker to visualize F-actin.
Nature methods 2008;5(7):605-7.
2008: Ewald Andrew J; Brenot Audrey; Duong Myhanh; Chan Bianca S; Werb Zena
Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis.
Developmental cell 2008;14(4):570-81.
2008: Martín-Belmonte Fernando; Yu Wei; Rodríguez-Fraticelli Alejo E; Ewald Andrew J; Werb Zena; Alonso Miguel A; Mostov Keith
Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis.
Current biology : CB 2008;18(7):507-13.
2008: Lu Pengfei; Yu Ying; Perdue Yasmine; Werb Zena
The apical ectodermal ridge is a timer for generating distal limb progenitors.
Development (Cambridge, England) 2008;135(8):1395-405.
2008: Kouros-Mehr Hosein; Kim Jung-whan; Bechis Seth K; Werb Zena
GATA-3 and the regulation of the mammary luminal cell fate.
Current opinion in cell biology 2008;20(2):164-70.
2008: Du Rose; Lu Kan V; Petritsch Claudia; Liu Patty; Ganss Ruth; Passegué Emmanuelle; Song Hanqiu; Vandenberg Scott; Johnson Randall S; Werb Zena; Bergers Gabriele
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion.
Cancer cell 2008;13(3):206-20.
2008: Kouros-Mehr Hosein; Bechis Seth K; Slorach Euan M; Littlepage Laurie E; Egeblad Mikala; Ewald Andrew J; Pai Sung-Yun; Ho I-Cheng; Werb Zena
GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model.
Cancer cell 2008;13(2):141-52.
2008: Welm Bryan E; Dijkgraaf Gerrit J P; Bledau Anita S; Welm Alana L; Werb Zena
Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer.
Cell stem cell 2008;2(1):90-102.
2008: Adler Adam S; Littlepage Laurie E; Lin Meihong; Kawahara Tiara L A; Wong David J; Werb Zena; Chang Howard Y
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression.
Cancer research 2008;68(2):506-15.
2008: Nielsen Boye S; Egeblad Mikala; Rank Fritz; Askautrud Hanne A; Pennington Caroline J; Pedersen Tanja X; Christensen Ib J; Edwards Dylan R; Werb Zena; Lund Leif R
Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression.
PloS one 2008;3(8):e2959.
2007: Heissig Beate; Lund Leif R; Akiyama Haruyo; Ohki Makiko; Morita Yohei; Rømer John; Nakauchi Hiromitsu; Okumura Ko; Ogawa Hideoki; Werb Zena; Danø Keld; Hattori Koichi
The plasminogen fibrinolytic pathway is required for hematopoietic regeneration.
Cell stem cell 2007;1(6):658-70.
2007: Sneddon Julie B; Werb Zena
Location, location, location: the cancer stem cell niche.
Cell stem cell 2007;1(6):607-11.
2007: Melani Cecilia; Sangaletti Sabina; Barazzetta Francesca M; Werb Zena; Colombo Mario P
Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma.
Cancer research 2007;67(23):11438-46.
2007: Weaver Valerie; Werb Zena
G'rab'bing the microenvironment for invasion.
Developmental cell 2007;13(4):462-3.
2007: Gutiérrez-Fernández Ana; Inada Masaki; Balbín Milagros; Fueyo Antonio; Pitiot Ana S; Astudillo Aurora; Hirose Kenji; Hirata Michiko; Shapiro Steven D; Noël Agnès; Werb Zena; Krane Stephen M; López-Otín Carlos; Puente Xose S
Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8).
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(10):2580-91.
2007: Fata Jimmie E; Mori Hidetoshi; Ewald Andrew J; Zhang Hui; Yao Evelyn; Werb Zena; Bissell Mina J
The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium.
Developmental biology 2007;306(1):193-207.
2007: Egeblad Mikala; Shen H-C Jennifer; Behonick Danielle J; Wilmes Lisa; Eichten Alexandra; Korets Lidiya V; Kheradmand Farrah; Werb Zena; Coussens Lisa M
Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(6):1683-93.
2007: Lemieux George A; Blumenkron Fernando; Yeung Nolan; Zhou Pei; Williams Jason; Grammer Amrie C; Petrovich Robert; Lipsky Peter E; Moss Marcia L; Werb Zena
The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10.
The Journal of biological chemistry 2007;282(20):14836-44.
2007: Yu Wei; Fang Xiaohui; Ewald Andrew; Wong Kit; Hunt C Anthony; Werb Zena; Matthay Michael A; Mostov Keith
Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis.
Molecular biology of the cell 2007;18(5):1693-700.
2007: Page-McCaw Andrea; Ewald Andrew J; Werb Zena
Matrix metalloproteinases and the regulation of tissue remodelling.
Nature reviews. Molecular cell biology 2007;8(3):221-33.
2007: Atabai Kamran; Sheppard Dean; Werb Zena
Roles of the innate immune system in mammary gland remodeling during involution.
Journal of mammary gland biology and neoplasia 2007;12(1):37-45.
2007: Greenlee Kendra J; Werb Zena; Kheradmand Farrah
Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted.
Physiological reviews 2007;87(1):69-98.
2007: Lum David H; Tan Jenille; Rosen Steven D; Werb Zena
Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2.
Molecular and cellular biology 2007;27(2):678-88.
2007: Levin Max; Ewald Andrew J; McMahon Martin; Werb Zena; Mostov Keith
A model of intussusceptive angiogenesis.
Novartis Foundation symposium 2007;283():37-42; discussion 42-5, 238-41.
2007: Behonick Danielle J; Xing Zhiqing; Lieu Shirley; Buckley Jenni M; Lotz Jeffrey C; Marcucio Ralph S; Werb Zena; Miclau Theodore; Colnot Céline
Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration.
PloS one 2007;2(11):e1150.
2006: Yeh Michael W; Rougier Jean-Philippe; Park Jin-Woo; Duh Quan-Yang; Wong Mariwil; Werb Zena; Clark Orlo H
Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.
Endocrine-related cancer 2006;13(4):1173-83.
2006: Kouros-Mehr Hosein; Slorach Euan M; Sternlicht Mark D; Werb Zena
GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland.
Cell 2006;127(5):1041-55.
2006: Kouros-Mehr Hosein; Werb Zena
Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis.
Developmental dynamics : an official publication of the American Association of Anatomists 2006;235(12):3404-12.
2006: Sternlicht Mark D; Dunning Alison M; Moore Dan H; Pharoah Paul D P; Ginzinger David G; Chin Koei; Gray Joe W; Waldman Frederic M; Ponder Bruce A J; Werb Zena
Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(11):2107-14.
2006: Greenlee Kendra J; Corry David B; Engler David A; Matsunami Risë K; Tessier Philippe; Cook Richard G; Werb Zena; Kheradmand Farrah
Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):7312-21.
2006: Lu Pengfei; Sternlicht Mark D; Werb Zena
Comparative mechanisms of branching morphogenesis in diverse systems.
Journal of mammary gland biology and neoplasia 2006;11(3-4):213-28.
2006: Hsu Jung-Yu C; McKeon Robert; Goussev Staci; Werb Zena; Lee Jung-Uek; Trivedi Alpa; Noble-Haeusslein Linda J
Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(39):9841-50.
2006: Sternlicht Mark D; Kouros-Mehr Hosein; Lu Pengfei; Werb Zena
Hormonal and local control of mammary branching morphogenesis.
Differentiation; research in biological diversity 2006;74(7):365-81.
2006: Lund Leif R; Green Kirsty A; Stoop Allart A; Ploug Michael; Almholt Kasper; Lilla Jennifer; Nielsen Boye S; Christensen Ib J; Craik Charles S; Werb Zena; Danø Keld; Rømer John
Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.
The EMBO journal 2006;25(12):2686-97.
2006: Jin David K; Shido Koji; Kopp Hans-Georg; Petit Isabelle; Shmelkov Sergey V; Young Lauren M; Hooper Andrea T; Amano Hideki; Avecilla Scott T; Heissig Beate; Hattori Koichi; Zhang Fan; Hicklin Daniel J; Wu Yan; Zhu Zhenping; Dunn Ashley; Salari Hassan; Werb Zena; Hackett Neil R; Crystal Ronald G; Lyden David; Rafii Shahin
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes.
Nature medicine 2006;12(5):557-67.
2006: Zeisberg Michael; Khurana Mona; Rao Velidi H; Cosgrove Dominic; Rougier Jean-Philippe; Werner Michelle C; Shield Charles F; Werb Zena; Kalluri Raghu
Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease.
PLoS medicine 2006;3(4):e100.
2006: Hartenstein Bettina; Dittrich Bernd Thilo; Stickens Dominique; Heyer Babette; Vu Thiennu H; Teurich Sibylle; Schorpp-Kistner Marina; Werb Zena; Angel Peter
Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice.
The Journal of investigative dermatology 2006;126(2):486-96.
2006: Uchimura Kenji; Morimoto-Tomita Megumi; Bistrup Annette; Li Jessica; Lyon Malcolm; Gallagher John; Werb Zena; Rosen Steven D
HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1.
BMC biochemistry 2006;7():2.
2005: Atabai Kamran; Fernandez Rafael; Huang Xiaozhu; Ueki Iris; Kline Ahnika; Li Yong; Sadatmansoori Sepid; Smith-Steinhart Christine; Zhu Weimin; Pytela Robert; Werb Zena; Sheppard Dean
Mfge8 is critical for mammary gland remodeling during involution.
Molecular biology of the cell 2005;16(12):5528-37.
2005: Wall Steven J; Werner Erica; Werb Zena; DeClerck Yves A
Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen.
The Journal of biological chemistry 2005;280(48):40187-94.
2005: Morimoto-Tomita Megumi; Uchimura Kenji; Bistrup Annette; Lum David H; Egeblad Mikala; Boudreau Nancy; Werb Zena; Rosen Steven D
Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer.
Neoplasia (New York, N.Y.) 2005;7(11):1001-10.
2005: Stickens Dominique; Zak Beverly M; Rougier Nathalie; Esko Jeffrey D; Werb Zena
Mice deficient in Ext2 lack heparan sulfate and develop exostoses.
Development (Cambridge, England) 2005;132(22):5055-68.
2005: Heissig Beate; Rafii Shahin; Akiyama Haruyo; Ohki Yuichi; Sato Yayoi; Rafael Tejada; Zhu Zhenping; Hicklin Daniel J; Okumura Ko; Ogawa Hideoki; Werb Zena; Hattori Koichi
Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization.
The Journal of experimental medicine 2005;202(6):739-50.
2005: Song Steven; Ewald Andrew J; Stallcup William; Werb Zena; Bergers Gabriele
PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival.
Nature cell biology 2005;7(9):870-9.
2005: Sternlicht Mark D; Sunnarborg Susan W; Kouros-Mehr Hosein; Yu Ying; Lee David C; Werb Zena
Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin.
Development (Cambridge, England) 2005;132(17):3923-33.
2005: Radisky Derek C; Levy Dinah D; Littlepage Laurie E; Liu Hong; Nelson Celeste M; Fata Jimmie E; Leake Devin; Godden Elizabeth L; Albertson Donna G; Nieto M Angela; Werb Zena; Bissell Mina J
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability.
Nature 2005;436(7047):123-7.
2005: Carlson Timothy R; Yan Yibing; Wu Xiaoqing; Lam Michael T; Tang Gale L; Beverly Levi J; Messina Louis M; Capobianco Anthony J; Werb Zena; Wang Rong
Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(28):9884-9.
2005: Heissig Beate; Ohki Yuichi; Sato Yayoi; Rafii Shahin; Werb Zena; Hattori Koichi
A role for niches in hematopoietic cell development.
Hematology (Amsterdam, Netherlands) 2005;10(3):247-53.
2005: Littlepage Laurie E; Egeblad Mikala; Werb Zena
Coevolution of cancer and stromal cellular responses.
Cancer cell 2005;7(6):499-500.
2005: Ortega Nathalie; Behonick Danielle J; Colnot Céline; Cooper Douglas N W; Werb Zena
Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation.
Molecular biology of the cell 2005;16(6):3028-39.
2005: Liu Zhi; Li Ning; Diaz Luis A; Shipley Michael; Senior Robert M; Werb Zena
Synergy between a plasminogen cascade and MMP-9 in autoimmune disease.
The Journal of clinical investigation 2005;115(4):879-87.
2005: Perez Sabina E; Cano David A; Dao-Pick Trang; Rougier Jean-Phillipe; Werb Zena; Hebrok Matthias
Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.
Diabetes 2005;54(3):694-701.
2005: Masson Véronique; de la Ballina Laura Rodriguez; Munaut Carine; Wielockx Ben; Jost Maud; Maillard Catherine; Blacher Silvia; Bajou Khalid; Itoh Takeshi; Itohara Shige; Werb Zena; Libert Claude; Foidart Jean-Michel; Noël Agnès
Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(2):234-6.
2005: Lee Marie Mei; Yoon Bong-June; Osiewicz Keith; Preston Michael; Bundy Brian; van Heeckeren Anna M; Werb Zena; Soloway Paul D
Tissue inhibitor of metalloproteinase 1 regulates resistance to infection.
Infection and immunity 2005;73(1):661-5.
2005: Egeblad M; Littlepage L E; Werb Z
The fibroblastic coconspirator in cancer progression.
Cold Spring Harbor symposia on quantitative biology 2005;70():383-8.
2004: Stickens Dominique; Behonick Danielle J; Ortega Nathalie; Heyer Babette; Hartenstein Bettina; Yu Ying; Fosang Amanda J; Schorpp-Kistner Marina; Angel Peter; Werb Zena
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice.
Development (Cambridge, England) 2004;131(23):5883-95.
2004: Wang Ke; Yamamoto Hiroaki; Chin Jennie R; Werb Zena; Vu Thiennu H
Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment.
The Journal of biological chemistry 2004;279(51):53848-56.
2004: Mott Joni D; Werb Zena
Regulation of matrix biology by matrix metalloproteinases.
Current opinion in cell biology 2004;16(5):558-64.
2004: Cases Sylvaine; Zhou Ping; Shillingford Jonathan M; Wiseman Bryony S; Fish Jo Dee; Angle Christina S; Hennighausen Lothar; Werb Zena; Farese Robert V
Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues.
Development (Cambridge, England) 2004;131(13):3047-55.
2004: Corry David B; Kiss Attila; Song Li-Zhen; Song Ling; Xu Jie; Lee Seung-Hyo; Werb Zena; Kheradmand Farrah
Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(9):995-7.
2004: Chantrain Christophe F; Shimada Hiroyuki; Jodele Sonata; Groshen Susan; Ye Wei; Shalinsky David R; Werb Zena; Coussens Lisa M; DeClerck Yves A
Stromal matrix metalloproteinase-9 regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment.
Cancer research 2004;64(5):1675-86.
2004: Ortega Nathalie; Behonick Danielle J; Werb Zena
Matrix remodeling during endochondral ossification.
Trends in cell biology 2004;14(2):86-93.
2004: Werb Zena
Zena Werb [interview by Fiona M Watt]
Journal of cell science 2004;117(Pt 6):803-4.
2004: Fata Jimmie E; Werb Zena; Bissell Mina J
Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes.
Breast cancer research : BCR 2004;6(1):1-11.
2003: Li Yi; Welm Bryan; Podsypanina Katrina; Huang Shixia; Chamorro Mario; Zhang Xiaomei; Rowlands Tracey; Egeblad Mikala; Cowin Pam; Werb Zena; Tan Lee K; Rosen Jeffrey M; Varmus Harold E
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15853-8.
2003: Man Albert K; Young Lawrence J T; Tynan John A; Lesperance Jacqueline; Egeblad Mikala; Werb Zena; Hauser Craig A; Muller William J; Cardiff Robert D; Oshima Robert G
Ets2-dependent stromal regulation of mouse mammary tumors.
Molecular and cellular biology 2003;23(23):8614-25.
2003: Lambert Vincent; Wielockx Ben; Munaut Carine; Galopin Catherine; Jost Maud; Itoh Takeshi; Werb Zena; Baker Andrew; Libert Claude; Krell Hans-Willi; Foidart Jean-Michel; Noël Agnès; Rakic Jean-Marie
MMP-2 and MMP-9 synergize in promoting choroidal neovascularization.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(15):2290-2.
2003: Behonick Danielle J; Werb Zena
A bit of give and take: the relationship between the extracellular matrix and the developing chondrocyte.
Mechanisms of development 2003;120(11):1327-36.
2003: Whetstone William D; Hsu Jung-Yu C; Eisenberg Manuel; Werb Zena; Noble-Haeusslein Linda J
Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing.
Journal of neuroscience research 2003;74(2):227-39.
2003: Heissig Beate; Werb Zena; Rafii Shahin; Hattori Koichi
Role of c-kit/Kit ligand signaling in regulating vasculogenesis.
Thrombosis and haemostasis 2003;90(4):570-6.
2003: Wiseman Bryony S; Sternlicht Mark D; Lund Leif R; Alexander Caroline M; Mott Joni; Bissell Mina J; Soloway Paul; Itohara Shigeyoshi; Werb Zena
Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis.
The Journal of cell biology 2003;162(6):1123-33.
2003: Parisi Tiziana; Beck Andreas R; Rougier Nathalie; McNeil Tom; Lucian Linda; Werb Zena; Amati Bruno
Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells.
The EMBO journal 2003;22(18):4794-803.
2003: Goussev Staci; Hsu Jung-Yu C; Lin Yong; Tjoa Tjoson; Maida Nino; Werb Zena; Noble-Haeusslein Linda J
Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing.
Journal of neurosurgery 2003;99(2 Suppl):188-97.
2003: Luk Hoenie W; Noble Linda J; Werb Zena
Macrophages contribute to the maintenance of stable regenerating neurites following peripheral nerve injury.
Journal of neuroscience research 2003;73(5):644-58.
2003: Solberg Helene; Rinkenberger Julie; Danø Keld; Werb Zena; Lund Leif R
A functional overlap of plasminogen and MMPs regulates vascularization during placental development.
Development (Cambridge, England) 2003;130(18):4439-50.
2003: Colnot Céline; Thompson Zachary; Miclau Theodore; Werb Zena; Helms Jill A
Altered fracture repair in the absence of MMP9.
Development (Cambridge, England) 2003;130(17):4123-33.
2003: Hamano Yuki; Zeisberg Michael; Sugimoto Hikaru; Lively Julie C; Maeshima Yohei; Yang Changqing; Hynes Richard O; Werb Zena; Sudhakar Akulapalli; Kalluri Raghu
Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin.
Cancer cell 2003;3(6):589-601.
2003: Slorach Euan M; Werb Zena
Epithelial morphogenesis: Netrin comes to a sticky and terminal end.
Current biology : CB 2003;13(12):R491-3.
2003: Gustafsson Erika; Aszodi Attila; Ortega Nathalie; Hunziker Ernst B; Denker Hans-Werner; Werb Zena; Fassler Reinhard
Role of collagen type II and perlecan in skeletal development.
Annals of the New York Academy of Sciences 2003;995():140-50.
2003: Ortega Nathalie; Behonick Danielle; Stickens Dominique; Werb Zena
How proteases regulate bone morphogenesis.
Annals of the New York Academy of Sciences 2003;995():109-16.
2003: Vu Thiennu H; Alemayehu Yemisrach; Werb Zena
New insights into saccular development and vascular formation in lung allografts under the renal capsule.
Mechanisms of development 2003;120(3):305-13.
2003: Heissig Beate; Hattori Koichi; Friedrich Matthias; Rafii Shahin; Werb Zena
Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases.
Current opinion in hematology 2003;10(2):136-41.
2003: Affolter Markus; Bellusci Savério; Itoh Nobuyuki; Shilo Benny; Thiery Jean-Paul; Werb Zena
Tube or not tube: remodeling epithelial tissues by branching morphogenesis.
Developmental cell 2003;4(1):11-8.
2002: Coussens Lisa M; Werb Zena
Inflammation and cancer.
Nature 2002;420(6917):860-7.
2002: Morimoto-Tomita Megumi; Uchimura Kenji; Werb Zena; Hemmerich Stefan; Rosen Steven D
Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans.
The Journal of biological chemistry 2002;277(51):49175-85.
2002: Ortega Nathalie; Werb Zena
New functional roles for non-collagenous domains of basement membrane collagens.
Journal of cell science 2002;115(Pt 22):4201-14.
2002: Hangai Masanori; Kitaya Norihiko; Xu Jingsong; Chan Candy K; Kim Jenny J; Werb Zena; Ryan Stephen J; Brooks Peter C
Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis.
The American journal of pathology 2002;161(4):1429-37.
2002: Lambert Vincent; Munaut Carine; Jost Maud; Noël Agnès; Werb Zena; Foidart Jean-Michel; Rakic Jean-Marie
Matrix metalloproteinase-9 contributes to choroidal neovascularization.
The American journal of pathology 2002;161(4):1247-53.
2002: Weaver Valerie M; Lelièvre Sophie; Lakins Johnathon N; Chrenek Micah A; Jones Jonathan C R; Giancotti Filippo; Werb Zena; Bissell Mina J
beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium.
Cancer cell 2002;2(3):205-16.
2002: Noble Linda J; Donovan Frances; Igarashi Takuji; Goussev Staci; Werb Zena
Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(17):7526-35.
2002: Hattori Koichi; Heissig Beate; Wu Yan; Dias Sergio; Tejada Rafael; Ferris Barbara; Hicklin Daniel J; Zhu Zhenping; Bohlen Peter; Witte Larry; Hendrikx Jan; Hackett Neil R; Crystal Ronald G; Moore Malcolm A S; Werb Zena; Lyden David; Rafii Shahin
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment.
Nature medicine 2002;8(8):841-9.
2002: Yan Yibing; Shirakabe Kyoko; Werb Zena
The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors.
The Journal of cell biology 2002;158(2):221-6.
2002: Werner Erica; Werb Zena
Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases.
The Journal of cell biology 2002;158(2):357-68.
2002: Heissig Beate; Hattori Koichi; Dias Sergio; Friedrich Matthias; Ferris Barbara; Hackett Neil R; Crystal Ronald G; Besmer Peter; Lyden David; Moore Malcolm A S; Werb Zena; Rafii Shahin
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand.
Cell 2002;109(5):625-37.
2002: Wiseman Bryony S; Werb Zena
Stromal effects on mammary gland development and breast cancer.
Science (New York, N.Y.) 2002;296(5570):1046-9.
2002: Lilla Jennifer; Stickens Dominique; Werb Zena
Metalloproteases and adipogenesis: a weighty subject.
The American journal of pathology 2002;160(5):1551-4.
2002: Corry David B; Rishi Kirtee; Kanellis John; Kiss Attila; Song Lz Li-zhen; Xu Jie; Feng Lili; Werb Zena; Kheradmand Farrah
Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency.
Nature immunology 2002;3(4):347-53.
2002: Egeblad Mikala; Werb Zena
New functions for the matrix metalloproteinases in cancer progression.
Nature reviews. Cancer 2002;2(3):161-74.
2002: Welm Bryan; Mott Joni; Werb Zena
Developmental biology: vasculogenesis is a wreck without RECK.
Current biology : CB 2002;12(6):R209-11.
2002: Kheradmand Farrah; Rishi Kirtee; Werb Zena
Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2.
Journal of cell science 2002;115(Pt 4):839-48.
2002: Kheradmand Farrah; Werb Zena
Shedding light on sheddases: role in growth and development.
BioEssays : news and reviews in molecular, cellular and developmental biology 2002;24(1):8-12.
2001: Chen R; Ning G; Zhao M L; Fleming M G; Diaz L A; Werb Z; Liu Z
Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid.
The Journal of clinical investigation 2001;108(8):1151-8.
2001: Werner E; Kheradmand F; Isberg R R; Werb Z
Phagocytosis mediated by Yersinia invasin induces collagenase-1 expression in rabbit synovial fibroblasts through a proinflammatory cascade.
Journal of cell science 2001;114(Pt 18):3333-43.
2001: Simian M; Hirai Y; Navre M; Werb Z; Lochter A; Bissell M J
The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells.
Development (Cambridge, England) 2001;128(16):3117-31.
2001: Rougier N; Werb Z
Minireview: Parthenogenesis in mammals.
Molecular reproduction and development 2001;59(4):468-74.
2001: Stoll S W; Kansra S; Peshick S; Fry D W; Leopold W R; Wiesen J F; Sibilia M; Zhang T; Werb Z; Derynck R; Wagner E F; Elder J T
Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes.
Neoplasia (New York, N.Y.) 2001;3(4):339-50.
2001: Sternlicht M D; Werb Z
How matrix metalloproteinases regulate cell behavior.
Annual review of cell and developmental biology 2001;17():463-516.
2001: Coussens L M; Shapiro S D; Soloway P D; Werb Z
Models for gain-of-function and loss-of-function of MMPs. Transgenic and gene targeted mice.
Methods in molecular biology (Clifton, N.J.) 2001;151():149-79.
2000: Coussens L M; Tinkle C L; Hanahan D; Werb Z
MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis.
Cell 2000;103(3):481-90.
2000: Bergers G; Brekken R; McMahon G; Vu T H; Itoh T; Tamaki K; Tanzawa K; Thorpe P; Itohara S; Werb Z; Hanahan D
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis.
Nature cell biology 2000;2(10):737-44.
2000: Lund L R; Bjørn S F; Sternlicht M D; Nielsen B S; Solberg H; Usher P A; Osterby R; Christensen I J; Stephens R W; Bugge T H; Danø K; Werb Z
Lactational competence and involution of the mouse mammary gland require plasminogen.
Development (Cambridge, England) 2000;127(20):4481-92.
2000: Liu Z; Zhou X; Shapiro S D; Shipley J M; Twining S S; Diaz L A; Senior R M; Werb Z
The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo.
Cell 2000;102(5):647-55.
2000: Vu T H; Werb Z
Matrix metalloproteinases: effectors of development and normal physiology.
Genes & development 2000;14(17):2123-33.
2000: Heyer B S; MacAuley A; Behrendtsen O; Werb Z
Hypersensitivity to DNA damage leads to increased apoptosis during early mouse development.
Genes & development 2000;14(16):2072-84.
2000: Wiesen J; Werb Z
Proteinases, cell cycle regulation, and apoptosis during mammary gland involution (minireview).
Molecular reproduction and development 2000;56(4):534-40.
2000: Pujuguet P; Simian M; Liaw J; Timpl R; Werb Z; Bissell M J
Nidogen-1 regulates laminin-1-dependent mammary-specific gene expression.
Journal of cell science 2000;113 ( Pt 5)():849-58.
2000: Sternlicht M D; Bissell M J; Werb Z
The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter.
Oncogene 2000;19(8):1102-13.
2000: Cunha G R; Wiesen J F; Werb Z; Young P; Hom Y K; Cooke P S; Lubahn D B
Paracrine mechanisms of mouse mammary ductal growth.
Advances in experimental medicine and biology 2000;480():93-7.
1999: Lochter A; Werb Z; Bissell M J
Transcriptional regulation of stromelysin-1 gene expression is altered during progression of mouse mammary epithelial cells from functionally normal to malignant.
Matrix biology : journal of the International Society for Matrix Biology 1999;18(5):455-67.
1999: Kornblum H I; Zurcher S D; Werb Z; Derynck R; Seroogy K B
Multiple trophic actions of heparin-binding epidermal growth factor (HB-EGF) in the central nervous system.
The European journal of neuroscience 1999;11(9):3236-46.
1999: Bullard K M; Lund L; Mudgett J S; Mellin T N; Hunt T K; Murphy B; Ronan J; Werb Z; Banda M J
Impaired wound contraction in stromelysin-1-deficient mice.
Annals of surgery 1999;230(2):260-5.
1999: Sternlicht M D; Lochter A; Sympson C J; Huey B; Rougier J P; Gray J W; Pinkel D; Bissell M J; Werb Z
The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis.
Cell 1999;98(2):137-46.
1999: Coussens L M; Raymond W W; Bergers G; Laig-Webster M; Behrendtsen O; Werb Z; Caughey G H; Hanahan D
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis.
Genes & development 1999;13(11):1382-97.
1999: Miettinen P J; Chin J R; Shum L; Slavkin H C; Shuler C F; Derynck R; Werb Z
Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure.
Nature genetics 1999;22(1):69-73.
1999: Lochter A; Navre M; Werb Z; Bissell M J
alpha1 and alpha2 integrins mediate invasive activity of mouse mammary carcinoma cells through regulation of stromelysin-1 expression.
Molecular biology of the cell 1999;10(2):271-82.
1999: Werb Z; Vu T H; Rinkenberger J L; Coussens L M
Matrix-degrading proteases and angiogenesis during development and tumor formation.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1999;107(1):11-8.
1999: Wiesen J F; Young P; Werb Z; Cunha G R
Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development.
Development (Cambridge, England) 1999;126(2):335-44.
1998: Werb Z; Yan Y
A cellular striptease act.
Science (New York, N.Y.) 1998;282(5392):1279-80.
1998: Lukashev M E; Werb Z
ECM signalling: orchestrating cell behaviour and misbehaviour.
Trends in cell biology 1998;8(11):437-41.
1998: Lochter A; Sternlicht M D; Werb Z; Bissell M J
The significance of matrix metalloproteinases during early stages of tumor progression.
Annals of the New York Academy of Sciences 1998;857():180-93.
1998: Werb Z; Chin J R
Extracellular matrix remodeling during morphogenesis.
Annals of the New York Academy of Sciences 1998;857():110-8.
1998: Uria J A; Werb Z
Matrix metalloproteinases and their expression in mammary gland.
Cell research 1998;8(3):187-94.
1998: Kornblum H I; Hussain R; Wiesen J; Miettinen P; Zurcher S D; Chow K; Derynck R; Werb Z
Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor.
Journal of neuroscience research 1998;53(6):697-717.
1998: Thomasset N; Lochter A; Sympson C J; Lund L R; Williams D R; Behrendtsen O; Werb Z; Bissell M J
Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early development.
The American journal of pathology 1998;153(2):457-67.
1998: Liu Z; Shipley J M; Vu T H; Zhou X; Diaz L A; Werb Z; Senior R M
Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid.
The Journal of experimental medicine 1998;188(3):475-82.
1998: Vu T H; Shipley J M; Bergers G; Berger J E; Helms J A; Hanahan D; Shapiro S D; Senior R M; Werb Z
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes.
Cell 1998;93(3):411-22.
1998: Yamamoto H; Flannery M L; Kupriyanov S; Pearce J; McKercher S R; Henkel G W; Maki R A; Werb Z; Oshima R G
Defective trophoblast function in mice with a targeted mutation of Ets2.
Genes & development 1998;12(9):1315-26.
1998: Kheradmand F; Werner E; Tremble P; Symons M; Werb Z
Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change.
Science (New York, N.Y.) 1998;280(5365):898-902.
1998: MacAuley A; Cross J C; Werb Z
Reprogramming the cell cycle for endoreduplication in rodent trophoblast cells.
Molecular biology of the cell 1998;9(4):795-807.
1998: Hom Y K; Young P; Wiesen J F; Miettinen P J; Derynck R; Werb Z; Cunha G R
Uterine and vaginal organ growth requires epidermal growth factor receptor signaling from stroma.
Endocrinology 1998;139(3):913-21.
1997: Lochter A; Galosy S; Muschler J; Freedman N; Werb Z; Bissell M J
Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells.
The Journal of cell biology 1997;139(7):1861-72.
1997: Werb Z
ECM and cell surface proteolysis: regulating cellular ecology.
Cell 1997;91(4):439-42.
1997: Padgett L C; Lui G M; Werb Z; LaVail M M
Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 in the retinal pigment epithelium and interphotoreceptor matrix: vectorial secretion and regulation.
Experimental eye research 1997;64(6):927-38.
1997: Miettinen P J; Warburton D; Bu D; Zhao J S; Berger J E; Minoo P; Koivisto T; Allen L; Dobbs L; Werb Z; Derynck R
Impaired lung branching morphogenesis in the absence of functional EGF receptor.
Developmental biology 1997;186(2):224-36.
1997: Mostov K; Werb Z
Journey across the osteoclast.
Science (New York, N.Y.) 1997;276(5310):219-20.
1997: Chin J R; Werb Z
Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular arch.
Development (Cambridge, England) 1997;124(8):1519-30.
1997: Lochter A; Srebrow A; Sympson C J; Terracio N; Werb Z; Bissell M J
Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties.
The Journal of biological chemistry 1997;272(8):5007-15.
1997: Behrendtsen O; Werb Z
Metalloproteinases regulate parietal endoderm differentiating and migrating in cultured mouse embryos.
Developmental dynamics : an official publication of the American Association of Anatomists 1997;208(2):255-65.
1997: Rinkenberger J L; Cross J C; Werb Z
Molecular genetics of implantation in the mouse.
Developmental genetics 1997;21(1):6-20.
1997: Newman-Smith E; Werb Z
Functional analysis of trophoblast giant cells in parthenogenetic mouse embryos.
Developmental genetics 1997;20(1):1-10.
1996: Alexander C M; Howard E W; Bissell M J; Werb Z
Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene.
The Journal of cell biology 1996;135(6 Pt 1):1669-77.
1996: La Fleur M; Underwood J L; Rappolee D A; Werb Z
Basement membrane and repair of injury to peripheral nerve: defining a potential role for macrophages, matrix metalloproteinases, and tissue inhibitor of metalloproteinases-1.
The Journal of experimental medicine 1996;184(6):2311-26.
1996: Coussens L M; Werb Z
Matrix metalloproteinases and the development of cancer.
Chemistry & biology 1996;3(11):895-904.
1996: Werb Z; Ashkenas J; MacAuley A; Wiesen J F
Extracellular matrix remodeling as a regulator of stromal-epithelial interactions during mammary gland development, involution and carcinogenesis.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1996;29(9):1087-97.
1996: Huttenlocher A; Werb Z; Tremble P; Huhtala P; Rosenberg L; Damsky C H
Decorin regulates collagenase gene expression in fibroblasts adhering to vitronectin.
Matrix biology : journal of the International Society for Matrix Biology 1996;15(4):239-50.
1996: Logan S K; Hansell E J; Damsky C H; Werb Z
T-antigen inhibits metalloproteinase expression and invasion in human placental cells transformed with temperature-sensitive simian virus 40.
Matrix biology : journal of the International Society for Matrix Biology 1996;15(2):81-9.
1996: Alexander C M; Hansell E J; Behrendtsen O; Flannery M L; Kishnani N S; Hawkes S P; Werb Z
Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation.
Development (Cambridge, England) 1996;122(6):1723-36.
1996: Werb Z; Sympson C J; Alexander C M; Thomasset N; Lund L R; MacAuley A; Ashkenas J; Bissell M J
Extracellular matrix remodeling and the regulation of epithelial-stromal interactions during differentiation and involution.
Kidney international. Supplement 1996;54():S68-74.
1996: Ashkenas J; Werb Z
Proteolysis and the biochemistry of life-or-death decisions.
The Journal of experimental medicine 1996;183(5):1947-51.
1996: Lund L R; Rømer J; Thomasset N; Solberg H; Pyke C; Bissell M J; Danø K; Werb Z
Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways.
Development (Cambridge, England) 1996;122(1):181-93.
1996: Logan S K; Garabedian M J; Campbell C E; Werb Z
Synergistic transcriptional activation of the tissue inhibitor of metalloproteinases-1 promoter via functional interaction of AP-1 and Ets-1 transcription factors.
The Journal of biological chemistry 1996;271(2):774-82.
1996: Wiesen J F; Werb Z
The role of stromelysin-1 in stromal-epithelial interactions and cancer.
Enzyme & protein 1996;49(1-3):174-81.
1995: Behrendtsen O; Alexander C M; Werb Z
Cooperative interactions between extracellular matrix, integrins and parathyroid hormone-related peptide regulate parietal endoderm differentiation in mouse embryos.
Development (Cambridge, England) 1995;121(12):4137-48.
1995: Cross J C; Flannery M L; Blanar M A; Steingrimsson E; Jenkins N A; Copeland N G; Rutter W J; Werb Z
Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development.
Development (Cambridge, England) 1995;121(8):2513-23.
1995: Hansell E J; Frisch S M; Tremble P; Murnane J P; Werb Z
Simian virus 40 transformation alters the actin cytoskeleton, expression of matrix metalloproteinases and inhibitors of metalloproteinases, and invasive behavior of normal and ataxia-telangiectasia human skin fibroblasts.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1995;73(7-8):373-89.
1995: Newman-Smith E D; Werb Z
Stem cell defects in parthenogenetic peri-implantation embryos.
Development (Cambridge, England) 1995;121(7):2069-77.
1995: Miettinen P J; Berger J E; Meneses J; Phung Y; Pedersen R A; Werb Z; Derynck R
Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor.
Nature 1995;376(6538):337-41.
1995: Tremble P; Damsky C H; Werb Z
Components of the nuclear signaling cascade that regulate collagenase gene expression in response to integrin-derived signals.
The Journal of cell biology 1995;129(6):1707-20.
1995: Sympson C J; Bissell M J; Werb Z
Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1.
Seminars in cancer biology 1995;6(3):159-63.
1995: Bissell M J; Werb Z
Introduction: basic science aspects of breast cancer.
Seminars in cancer biology 1995;6(3):117-8.
1995: Huhtala P; Humphries M J; McCarthy J B; Tremble P M; Werb Z; Damsky C H
Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin.
The Journal of cell biology 1995;129(3):867-79.
1995: Boudreau N; Sympson C J; Werb Z; Bissell M J
Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix.
Science (New York, N.Y.) 1995;267(5199):891-3.
1994: Tournier J M; Polette M; Hinnrasky J; Beck J; Werb Z; Basbaum C
Expression of gelatinase A, a mediator of extracellular matrix remodeling, by tracheal gland serous cells in culture and in vivo.
The Journal of biological chemistry 1994;269(41):25454-64.
1994: Rappolee D A; Basilico C; Patel Y; Werb Z
Expression and function of FGF-4 in peri-implantation development in mouse embryos.
Development (Cambridge, England) 1994;120(8):2259-69.
1994: Sympson C J; Talhouk R S; Alexander C M; Chin J R; Clift S M; Bissell M J; Werb Z
Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression.
The Journal of cell biology 1994;125(3):681-93.
1994: Tremble P; Chiquet-Ehrismann R; Werb Z
The extracellular matrix ligands fibronectin and tenascin collaborate in regulating collagenase gene expression in fibroblasts.
Molecular biology of the cell 1994;5(4):439-53.
1993: Tremble P M; Lane T F; Sage E H; Werb Z
SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway.
The Journal of cell biology 1993;121(6):1433-44.
1993: Sanchez-Lopez R; Alexander C M; Behrendtsen O; Breathnach R; Werb Z
Role of zinc-binding- and hemopexin domain-encoded sequences in the substrate specificity of collagenase and stromelysin-2 as revealed by chimeric proteins.
The Journal of biological chemistry 1993;268(10):7238-47.
1992: Damsky C H; Werb Z
Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information.
Current opinion in cell biology 1992;4(5):772-81.
1992: Talhouk R S; Bissell M J; Werb Z
Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution.
The Journal of cell biology 1992;118(5):1271-82.
1992: Alexander C M; Werb Z
Targeted disruption of the tissue inhibitor of metalloproteinases gene increases the invasive behavior of primitive mesenchymal cells derived from embryonic stem cells in vitro.
The Journal of cell biology 1992;118(3):727-39.
1992: Rappolee D A; Sturm K S; Behrendtsen O; Schultz G A; Pedersen R A; Werb Z
Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos.
Genes & development 1992;6(6):939-52.
1992: Behrendtsen O; Alexander C M; Werb Z
Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths.
Development (Cambridge, England) 1992;114(2):447-56.
1992: Werb Z; Alexander C M; Adler R R
Expression and function of matrix metalloproteinases in development.
Matrix (Stuttgart, Germany). Supplement 1992;1():337-43.
1992: Underwood J L; Rappolee D A; Flannery M; Werb Z
Tissue inhibitor of metalloproteinases is induced by nerve damage.
Matrix (Stuttgart, Germany). Supplement 1992;1():330-1.
1992: Tremble P M; Damsky C H; Werb Z
Fibronectin fragments, but not intact fibronectin, signalling through the fibronectin receptor induce metalloproteinase gene expression in fibroblasts.
Matrix (Stuttgart, Germany). Supplement 1992;1():212-4.
1992: Alexander C M; Behrendtsen O; Goldsmith J; Sturm K; Werb Z
A genetic approach to identifying the functions of metalloproteinases and their inhibitors in adult and developing mice.
Matrix (Stuttgart, Germany). Supplement 1992;1():201-2.
1992: Damsky C; Tremble P; Werb Z
Signal transduction via the fibronectin receptor: do integrins regulate matrix remodeling?
Matrix (Stuttgart, Germany). Supplement 1992;1():184-91.
1991: Talhouk R S; Chin J R; Unemori E N; Werb Z; Bissell M J
Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture.
Development (Cambridge, England) 1991;112(2):439-49.
1991: Librach C L; Werb Z; Fitzgerald M L; Chiu K; Corwin N M; Esteves R A; Grobelny D; Galardy R; Damsky C H; Fisher S J
92-kD type IV collagenase mediates invasion of human cytotrophoblasts.
The Journal of cell biology 1991;113(2):437-49.
1990: Werb Z; Tremble P; Damsky C H
Regulation of extracellular matrix degradation by cell-extracellular matrix interactions.
Cell differentiation and development : the official journal of the International Society of Developmental Biologists 1990;32(3):299-306.
1990: Handagama P; Rappolee D A; Werb Z; Levin J; Bainton D F
Platelet alpha-granule fibrinogen, albumin, and immunoglobulin G are not synthesized by rat and mouse megakaryocytes.
The Journal of clinical investigation 1990;86(4):1364-8.
1990: Hahnel A C; Rappolee D A; Millan J L; Manes T; Ziomek C A; Theodosiou N G; Werb Z; Pedersen R A; Schultz G A
Two alkaline phosphatase genes are expressed during early development in the mouse embryo.
Development (Cambridge, England) 1990;110(2):555-64.
1990: Adler R R; Brenner C A; Werb Z
Expression of extracellular matrix-degrading metalloproteinases and metalloproteinase inhibitors is developmentally regulated during endoderm differentiation of embryonal carcinoma cells.
Development (Cambridge, England) 1990;110(1):211-20.
1990: Rappolee D A; Werb Z
mRNA phenotyping for studying gene expression in small numbers of cells: platelet-derived growth factor and other growth factors in wound-derived macrophages.
American journal of respiratory cell and molecular biology 1990;2(1):3-10.
1990: Unemori E N; Bouhana K S; Werb Z
Vectorial secretion of extracellular matrix proteins, matrix-degrading proteinases, and tissue inhibitor of metalloproteinases by endothelial cells.
The Journal of biological chemistry 1990;265(1):445-51.
1989: Alexander C M; Werb Z
Proteinases and extracellular matrix remodeling.
Current opinion in cell biology 1989;1(5):974-82.
1989: Werb Z; Tremble P M; Behrendtsen O; Crowley E; Damsky C H
Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.
The Journal of cell biology 1989;109(2):877-89.
1989: Brenner C A; Adler R R; Rappolee D A; Pedersen R A; Werb Z
Genes for extracellular-matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development.
Genes & development 1989;3(6):848-59.
1989: Werb Z; Clark E J
Phorbol diesters regulate expression of the membrane neutral metalloendopeptidase (EC 3.4.24.11) in rabbit synovial fibroblasts and mammary epithelial cells.
The Journal of biological chemistry 1989;264(16):9111-3.
1989: Werb Z; Takemura R; Stenberg P E; Bainton D F
Directed exocytosis of secretory granules containing apolipoprotein E to the adherent surface and basal vacuoles of macrophages spreading on immobile immune complexes.
The American journal of pathology 1989;134(3):661-70.
1989: Bainton D F; Takemura R; Stenberg P E; Werb Z
Rapid fragmentation and reorganization of Golgi membranes during frustrated phagocytosis of immobile immune complexes by macrophages.
The American journal of pathology 1989;134(1):15-26.
1989: Rappolee D A; Wang A; Mark D; Werb Z
Novel method for studying mRNA phenotypes in single or small numbers of cells.
Journal of cellular biochemistry 1989;39(1):1-11.
1988: Unemori E N; Werb Z
Collagenase expression and endogenous activation in rabbit synovial fibroblasts stimulated by the calcium ionophore A23187.
The Journal of biological chemistry 1988;263(31):16252-9.
1988: Rappolee D A; Brenner C A; Schultz R; Mark D; Werb Z
Developmental expression of PDGF, TGF-alpha, and TGF-beta genes in preimplantation mouse embryos.
Science (New York, N.Y.) 1988;241(4874):1823-5.
1988: Rappolee D A; Werb Z
Secretory products of phagocytes.
Current opinion in immunology 1988;1(1):47-55.
1988: Rappolee D A; Mark D; Banda M J; Werb Z
Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping.
Science (New York, N.Y.) 1988;241(4866):708-12.
1988: Banda M J; Herron G S; Murphy G; Werb Z; Dwyer K S
Proteinase induction by endothelial cells during wound repair.
Progress in clinical and biological research 1988;266():117-30.
1986: Herron G S; Banda M J; Clark E J; Gavrilovic J; Werb Z
Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.
The Journal of biological chemistry 1986;261(6):2814-8.
1986: Herron G S; Werb Z; Dwyer K; Banda M J
Secretion of metalloproteinases by stimulated capillary endothelial cells. I. Production of procollagenase and prostromelysin exceeds expression of proteolytic activity.
The Journal of biological chemistry 1986;261(6):2810-3.
1986: Takemura R; Stenberg P E; Bainton D F; Werb Z
Rapid redistribution of clathrin onto macrophage plasma membranes in response to Fc receptor-ligand interaction during frustrated phagocytosis.
The Journal of cell biology 1986;102(1):55-69.
1985: Banda M J; Clark E J; Werb Z
Regulation of alpha 1 proteinase inhibitor function by rabbit alveolar macrophages. Evidence for proteolytic rather than oxidative inactivation.
The Journal of clinical investigation 1985;75(6):1758-62.
1983: Banda M J; Clark E J; Werb Z
Selective proteolysis of immunoglobulins by mouse macrophage elastase.
The Journal of experimental medicine 1983;157(4):1184-96.
1980: Banda M J; Clark E J; Werb Z
Limited proteolysis by macrophage elastase inactivates human alpha 1-proteinase inhibitor.
The Journal of experimental medicine 1980;152(6):1563-70.

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