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Robert Brasseur

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequence

Chemicals & Drugs

Anatomy

Lipid Bilayers

Physiology

Phenomena

Protein Binding

Activities & Behaviors

Computer Simulation

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Co-Publications
Name
27
Ruysschaert, Jean-Marie
26
Thomas, Annick
26
Lins, Laurence
25
Rosseneu, Maryvonne
20
Mingeot-Leclercq, Marie-Paule
20
Charloteaux, Benoit
18
Vanloo, Berlinda
17
Lins, L
12
Goormaghtigh, Erik
12
Tulkens, Paul
11
Vandekerckhove, Joël
10
Labeur, Christine
10
Schanck, André
9
Gallet, X
8
Goethals, Marc

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Publications

TOP 3
Vandermoten Sophie; Santini Sébastien; Haubruge Eric; Heuze Fabien; Francis Frédéric; Brasseur Robert; Cusson Michel; Charloteaux Benoit
Structural features conferring dual geranyl/farnesyl diphosphate synthase activity to an aphid prenyltransferase.
Prevot Pierre-Paul; Beschin Alain; Lins Laurence; Beaufays Jérôme; Grosjean Amélie; Bruys Léa; Adam Benoît; Brossard Michel; Brasseur Robert; Zouaoui Boudjeltia Karim; Vanhamme Luc; Godfroid Edmond
Exosites mediate the anti-inflammatory effects of a multifunctional serpin from the saliva of the tick Ixodes ricinus.
Charloteaux B; Lorin A; Brasseur R; Lins L
The "Tilted Peptide Theory" links membrane insertion properties and fusogenicity of viral fusion peptides.

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All Publications

2009: Vandermoten Sophie; Santini Sébastien; Haubruge Eric; Heuze Fabien; Francis Frédéric; Brasseur Robert; Cusson Michel; Charloteaux Benoit
Structural features conferring dual geranyl/farnesyl diphosphate synthase activity to an aphid prenyltransferase.
Insect biochemistry and molecular biology 2009;39(10):707-16.
2009: Prevot Pierre-Paul; Beschin Alain; Lins Laurence; Beaufays Jérôme; Grosjean Amélie; Bruys Léa; Adam Benoît; Brossard Michel; Brasseur Robert; Zouaoui Boudjeltia Karim; Vanhamme Luc; Godfroid Edmond
Exosites mediate the anti-inflammatory effects of a multifunctional serpin from the saliva of the tick Ixodes ricinus.
The FEBS journal 2009;276(12):3235-46.
2009: Charloteaux B; Lorin A; Brasseur R; Lins L
The "Tilted Peptide Theory" links membrane insertion properties and fusogenicity of viral fusion peptides.
Protein and peptide letters 2009;16(7):718-25.
2009: Thomas Annick; Deshayes Sébastien; Decaffmeyer Marc; Van Eyck Marie-Hélène; Charloteaux Benoit B; Brasseur Robert
PepLook: an innovative in silico tool for determination of structure, polymorphism and stability of peptides.
Advances in experimental medicine and biology 2009;611():459-60.
2009: Lorin Aurélien; Charloteaux Benoît; Lins Laurence; Stroobant Vincent; Brasseur Robert
Determination of the minimal fusion peptide of HIV, SIV and BLV fusion glycoproteins.
Advances in experimental medicine and biology 2009;611():387-8.
2008: Decaffmeyer Marc; Shulga Yulia V; Dicu Armela O; Thomas Annick; Truant Ray; Topham Matthew K; Brasseur Robert; Epand Richard M
Determination of the topology of the hydrophobic segment of mammalian diacylglycerol kinase epsilon in a cell membrane and its relationship to predictions from modeling.
Journal of molecular biology 2008;383(4):797-809.
2008: Lins L; Decaffmeyer M; Thomas A; Brasseur R
Relationships between the orientation and the structural properties of peptides and their membrane interactions.
Biochimica et biophysica acta 2008;1778(7-8):1537-44.
2008: Vandermoten Sophie; Charloteaux Benoit; Santini Sébastien; Sen Stephanie E; Béliveau Catherine; Vandenbol Micheline; Francis Frédéric; Brasseur Robert; Cusson Michel; Haubruge Eric
Characterization of a novel aphid prenyltransferase displaying dual geranyl/farnesyl diphosphate synthase activity.
FEBS letters 2008;582(13):1928-34.
2008: Deshayes Sébastien; Decaffmeyer Marc; Brasseur Robert; Thomas Annick
Structural polymorphism of two CPP: an important parameter of activity.
Biochimica et biophysica acta 2008;1778(5):1197-205.
2008: Lins L; Brasseur R
Tilted peptides: a structural motif involved in protein membrane insertion?
Journal of peptide science : an official publication of the European Peptide Society 2008;14(4):416-22.
2008: Lorin Aurélien; Lins Laurence; Stroobant Vincent; Brasseur Robert; Charloteaux Benoit
The minimal fusion peptide of simian immunodeficiency virus corresponds to the 11 first residues of gp32.
Journal of peptide science : an official publication of the European Peptide Society 2008;14(4):423-8.
2008: Mingeot-Leclercq Marie-Paule; Deleu Magali; Brasseur Robert; Dufrêne Yves F
Atomic force microscopy of supported lipid bilayers.
Nature protocols 2008;3(10):1654-9.
2008: Adam Benoit; Charloteaux Benoit; Beaufays Jerome; Vanhamme Luc; Godfroid Edmond; Brasseur Robert; Lins Laurence
Distantly related lipocalins share two conserved clusters of hydrophobic residues: use in homology modeling.
BMC structural biology 2008;8():1.
2007: Andre Guillaume; Brasseur Robert; Dufrêne Yves F
Probing the interaction forces between hydrophobic peptides and supported lipid bilayers using AFM.
Journal of molecular recognition : JMR 2007;20(6):538-45.
2007: Lins L; El Kirat K; Charloteaux B; Flore C; Stroobant V; Thomas A; Dufrene Y; Brasseur R
Lipid-destabilizing properties of the hydrophobic helices H8 and H9 from colicin E1.
Molecular membrane biology 2007;24(5-6):419-30.
2007: Brasseur Robert; Braun Nathalie; El Kirat Karim; Deleu Magali; Mingeot-Leclercq Marie-Paule; Dufrêne Yves F
The biologically important surfactin lipopeptide induces nanoripples in supported lipid bilayers.
Langmuir : the ACS journal of surfaces and colloids 2007;23(19):9769-72.
2007: Crowet Jean-Marc; Lins Laurence; Dupiereux Ingrid; Elmoualija Benaïssa; Lorin Aurélien; Charloteaux Benoit; Stroobant Vincent; Heinen Ernst; Brasseur Robert
Tilted properties of the 67-78 fragment of alpha-synuclein are responsible for membrane destabilization and neurotoxicity.
Proteins 2007;68(4):936-47.
2007: Fa N; Lins L; Courtoy P J; Dufrêne Y; Van Der Smissen P; Brasseur R; Tyteca D; Mingeot-Leclercq M-P
Decrease of elastic moduli of DOPC bilayers induced by a macrolide antibiotic, azithromycin.
Biochimica et biophysica acta 2007;1768(7):1830-8.
2007: Bouffioux O; Berquand A; Eeman M; Paquot M; Dufrêne Y F; Brasseur R; Deleu M
Molecular organization of surfactin-phospholipid monolayers: effect of phospholipid chain length and polar head.
Biochimica et biophysica acta 2007;1768(7):1758-68.
2007: Lorin Aurélien; Charloteaux Benoit; Fridmann-Sirkis Yael; Thomas Annick; Shai Yechiel; Brasseur Robert
Mode of membrane interaction and fusogenic properties of a de novo transmembrane model peptide depend on the length of the hydrophobic core.
The Journal of biological chemistry 2007;282(25):18388-96.
2007: Lorin Aurélien; Lins Laurence; Stroobant Vincent; Brasseur Robert; Charloteaux Benoit
Determination of the minimal fusion peptide of bovine leukemia virus gp30.
Biochemical and biophysical research communications 2007;355(3):649-53.
2006: Thomas Annick; Brasseur Robert
Tilted peptides: the history.
Current protein & peptide science 2006;7(6):523-7.
2006: Thomas Annick; Deshayes Sébastien; Decaffmeyer Marc; Van Eyck Marie Hélène; Charloteaux Benoit; Brasseur Robert
Prediction of peptide structure: how far are we?
Proteins 2006;65(4):889-97.
2006: Nguyen Ngoc-Quynh-Nhu; Tabruyn Sebastien P; Lins Laurence; Lion Michelle; Cornet Anne M; Lair Florence; Rentier-Delrue Francoise; Brasseur Robert; Martial Joseph A; Struman Ingrid
Prolactin/growth hormone-derived antiangiogenic peptides highlight a potential role of tilted peptides in angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14319-24.
2006: Leimanis S; Hoyez N; Hubert S; Laschet M; Sauvage Eric; Brasseur R; Coyette J
PBP5 complementation of a PBP3 deficiency in Enterococcus hirae.
Journal of bacteriology 2006;188(17):6298-307.
2006: Prevot Pierre-Paul; Adam Benoit; Boudjeltia Karim Zouaoui; Brossard Michel; Lins Laurence; Cauchie Philippe; Brasseur Robert; Vanhaeverbeek Michel; Vanhamme Luc; Godfroid Edmond
Anti-hemostatic effects of a serpin from the saliva of the tick Ixodes ricinus.
The Journal of biological chemistry 2006;281(36):26361-9.
2006: El Kirat Karim; Dufrêne Yves F; Lins Laurence; Brasseur Robert
The SIV tilted peptide induces cylindrical reverse micelles in supported lipid bilayers.
Biochemistry 2006;45(30):9336-41.
2006: Charloteaux B; Lorin A; Crowet J M; Stroobant V; Lins L; Thomas A; Brasseur R
The N-terminal 12 residue long peptide of HIV gp41 is the minimal peptide sufficient to induce significant T-cell-like membrane destabilization in vitro.
Journal of molecular biology 2006;359(3):597-609.
2006: Lorin A; Thomas A; Stroobant V; Brasseur R; Lins L
Lipid-destabilising properties of a peptide with structural plasticity.
Chemistry and physics of lipids 2006;141(1-2):185-96.
2006: Decaffmeyer Marc; Lins Laurence; Charloteaux Benoit; VanEyck Marie Hélène; Thomas Annick; Brasseur Robert
Rational design of complementary peptides to the betaAmyloid 29-42 fusion peptide: an application of PepDesign.
Biochimica et biophysica acta 2006;1758(3):320-7.
2006: Lins L; Charloteaux B; Heinen C; Thomas A; Brasseur R
"De novo" design of peptides with specific lipid-binding properties.
Biophysical journal 2006;90(2):470-9.
2005: Thomas Annick; Allouche Maya; Basyn Frédéric; Brasseur Robert; Kerfelec Brigitte
Role of the lid hydrophobicity pattern in pancreatic lipase activity.
The Journal of biological chemistry 2005;280(48):40074-83.
2005: Lejeune Diane; Delsaux Nicolas; Charloteaux Benoît; Thomas Annick; Brasseur Robert
Protein-nucleic acid recognition: statistical analysis of atomic interactions and influence of DNA structure.
Proteins 2005;61(2):258-71.
2005: Hazlett Karsten R O; Cox David L; Decaffmeyer Marc; Bennett Michael P; Desrosiers Daniel C; La Vake Carson J; La Vake Morgan E; Bourell Kenneth W; Robinson Esther J; Brasseur Robert; Radolf Justin D
TP0453, a concealed outer membrane protein of Treponema pallidum, enhances membrane permeability.
Journal of bacteriology 2005;187(18):6499-508.
2005: Pérez-Morga David; Vanhollebeke Benoit; Paturiaux-Hanocq Françoise; Nolan Derek P; Lins Laurence; Homblé Fabrice; Vanhamme Luc; Tebabi Patricia; Pays Annette; Poelvoorde Philippe; Jacquet Alain; Brasseur Robert; Pays Etienne
Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes.
Science (New York, N.Y.) 2005;309(5733):469-72.
2005: Dupiereux Ingrid; Zorzi Willy; Lins Laurence; Brasseur Robert; Colson Pierre; Heinen Ernst; Elmoualij Benaïssa
Interaction of the 106-126 prion peptide with lipid membranes and potential implication for neurotoxicity.
Biochemical and biophysical research communications 2005;331(4):894-901.
2005: Ravault Stéphanie; Soubias Olivier; Saurel Olivier; Thomas Annick; Brasseur Robert; Milon Alain
Fusogenic Alzheimer's peptide fragment Abeta (29-42) in interaction with lipid bilayers: secondary structure, dynamics, and specific interaction with phosphatidyl ethanolamine polar heads as revealed by solid-state NMR.
Protein science : a publication of the Protein Society 2005;14(5):1181-9.
2005: El Kirat Karim; Lins Laurence; Brasseur Robert; Dufrêne Yves F
Fusogenic tilted peptides induce nanoscale holes in supported phosphatidylcholine bilayers.
Langmuir : the ACS journal of surfaces and colloids 2005;21(7):3116-21.
2005: Chahboune Aicha; Decaffmeyer Marc; Brasseur Robert; Joris Bernard
Membrane topology of the Escherichia coli AmpG permease required for recycling of cell wall anhydromuropeptides and AmpC beta-lactamase induction.
Antimicrobial agents and chemotherapy 2005;49(3):1145-9.
2005: Ho Bosco K; Brasseur Robert
The Ramachandran plots of glycine and pre-proline.
BMC structural biology 2005;5():14.
2004: Pastoret Soumya; Fraipont Claudine; den Blaauwen Tanneke; Wolf Benoît; Aarsman Mirjam E G; Piette André; Thomas Annick; Brasseur Robert; Nguyen-Distèche Martine
Functional analysis of the cell division protein FtsW of Escherichia coli.
Journal of bacteriology 2004;186(24):8370-9.
2004: Thomas Annick; Milon Alain; Brasseur Robert
Partial atomic charges of amino acids in proteins.
Proteins 2004;56(1):102-9.
2004: Krell Tino; Greco Frédéric; Engel Olivier; Dubayle Jean; Dubayle Joseline; Kennel Audrey; Charloteaux Benoit; Brasseur Robert; Chevalier Michel; Sodoyer Regis; El Habib Raphaëlle
HIV-1 gp41 and gp160 are hyperthermostable proteins in a mesophilic environment. Characterization of gp41 mutants.
European journal of biochemistry / FEBS 2004;271(8):1566-79.
2004: Meurisse Rita; Brasseur Robert; Thomas Annick
Aromatic side-chain interactions in proteins: near- and far-sequence Tyr-X pairs.
Proteins 2004;54(3):478-90.
2004: Adam B; Lins L; Stroobant V; Thomas A; Brasseur R
Distribution of hydrophobic residues is crucial for the fusogenic properties of the Ebola virus GP2 fusion peptide.
Journal of virology 2004;78(4):2131-6.
2004: Renauld-Mongénie Geneviève; Lins Laurence; Krell Tino; Laffly Laure; Mignon Michèle; Dupuy Monique; Delrue Rose-May; Guinet-Morlot Françoise; Brasseur Robert; Lissolo Ling
Transferrin-binding protein B of Neisseria meningitidis: sequence-based identification of the transferrin-Binding site confirmed by site-directed mutagenesis.
Journal of bacteriology 2004;186(3):850-7.
2003: Ho Bosco K; Thomas Annick; Brasseur Robert
Revisiting the Ramachandran plot: hard-sphere repulsion, electrostatics, and H-bonding in the alpha-helix.
Protein science : a publication of the Protein Society 2003;12(11):2508-22.
2003: Basyn Frederic; Spies Benoit; Bouffioux Olivier; Thomas Annick; Brasseur Robert
Insertion of X-ray structures of proteins in membranes.
Journal of molecular graphics & modelling 2003;22(1):11-21.
2003: Lins Laurence; Thomas Annick; Brasseur Robert
Analysis of accessible surface of residues in proteins.
Protein science : a publication of the Protein Society 2003;12(7):1406-17.
2003: Meurisse Rita; Brasseur Robert; Thomas Annick
Aromatic side-chain interactions in proteins. Near- and far-sequence His-X pairs.
Biochimica et biophysica acta 2003;1649(1):85-96.
2003: Vanhamme Luc; Paturiaux-Hanocq Françoise; Poelvoorde Philippe; Nolan Derek P; Lins Laurence; Van Den Abbeele Jan; Pays Annette; Tebabi Patricia; Van Xong Huang; Jacquet Alain; Moguilevsky Nicole; Dieu Marc; Kane John P; De Baetselier Patrick; Brasseur Robert; Pays Etienne
Apolipoprotein L-I is the trypanosome lytic factor of human serum.
Nature 2003;422(6927):83-7.
2003: Dom Geneviève; Shaw-Jackson Chloë; Matis Christelle; Bouffioux Olivier; Picard Jacques J; Prochiantz Alain; Mingeot-Leclercq Marie-Paule; Brasseur Robert; Rezsohazy René
Cellular uptake of Antennapedia Penetratin peptides is a two-step process in which phase transfer precedes a tryptophan-dependent translocation.
Nucleic acids research 2003;31(2):556-61.
2003: Mingeot-Leclercq Marie-Paule; Lins Laurence; Bensliman Mariam; Thomas Annick; Van Bambeke Françoise; Peuvot Jacques; Schanck André; Brasseur Robert
Piracetam inhibits the lipid-destabilising effect of the amyloid peptide Abeta C-terminal fragment.
Biochimica et biophysica acta 2003;1609(1):28-38.
2002: Mingeot-Leclercq Marie Paule; Lins Laurence; Bensliman Mariam; Van Bambeke Françoise; Van Der Smissen Patrick; Peuvot Jacques; Schanck André; Brasseur Robert
Membrane destabilization induced by beta-amyloid peptide 29-42: importance of the amino-terminus.
Chemistry and physics of lipids 2002;120(1-2):57-74.
2002: Thomas Annick; Meurisse Rita; Brasseur Robert
Aromatic side-chain interactions in proteins. II. Near- and far-sequence Phe-X pairs.
Proteins 2002;48(4):635-44.
2002: Thomas Annick; Meurisse Rita; Charloteaux Benoit; Brasseur Robert
Aromatic side-chain interactions in proteins. I. Main structural features.
Proteins 2002;48(4):628-34.
2002: Lins L; Flore C; Chapelle L; Talmud P J; Thomas A; Brasseur R
Lipid-interacting properties of the N-terminal domain of human apolipoprotein C-III.
Protein engineering 2002;15(6):513-20.
2002: Charloteaux Benoit; Lins Laurence; Moereels Henri; Brasseur Robert
Analysis of the C-terminal membrane anchor domains of hepatitis C virus glycoproteins E1 and E2: toward a topological model.
Journal of virology 2002;76(4):1944-58.
2001: Mingeot-Leclercq M P; Gallet X; Flore C; Van Bambeke F; Peuvot J; Brasseur R
Experimental and conformational analyses of interactions between butenafine and lipids.
Antimicrobial agents and chemotherapy 2001;45(12):3347-54.
2001: Lins L; Charloteaux B; Thomas A; Brasseur R
Computational study of lipid-destabilizing protein fragments: towards a comprehensive view of tilted peptides.
Proteins 2001;44(4):435-47.
2001: Deleu M; Nott K; Brasseur R; Jacques P; Thonart P; Dufrêne Y F
Imaging mixed lipid monolayers by dynamic atomic force microscopy.
Biochimica et biophysica acta 2001;1513(1):55-62.
2001: Festy F; Lins L; Péranzi G; Octave J N; Brasseur R; Thomas A
Is aggregation of beta-amyloid peptides a mis-functioning of a current interaction process?
Biochimica et biophysica acta 2001;1546(2):356-64.
2001: Thomas A; Benhabiles N; Meurisse R; Ngwabije R; Brasseur R
Pex, analytical tools for PDB files. II. H-Pex: noncanonical H-bonds in alpha-helices.
Proteins 2001;43(1):37-44.
2001: Thomas A; Bouffioux O; Geeurickx D; Brasseur R
Pex, analytical tools for PDB files. I. GF-Pex: basic file to describe a protein.
Proteins 2001;43(1):28-36.
2001: Festy F; Robert J C; Brasseur R; Thomas A
Interaction between the N-terminal domain of gastric H,K-ATPase and the spectrin binding domain of ankyrin III.
The Journal of biological chemistry 2001;276(11):7721-6.
2001: Basyn F; Charloteaux B; Thomas A; Brasseur R
Prediction of membrane protein orientation in lipid bilayers: a theoretical approach.
Journal of molecular graphics & modelling 2001;20(3):235-44.
2000: Ducarme P; Thomas A; Brasseur R
The optimisation of the helix/helix interaction of a transmembrane dimer is improved by the IMPALA restraint field.
Biochimica et biophysica acta 2000;1509(1-2):148-54.
2000: Liu H; Labeur C; Xu C F; Ferrell R; Lins L; Brasseur R; Rosseneu M; Weiss K M; Humphries S E; Talmud P J
Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr.
Journal of lipid research 2000;41(11):1760-71.
2000: Vogt B; Ducarme P; Schinzel S; Brasseur R; Bechinger B
The topology of lysine-containing amphipathic peptides in bilayers by circular dichroism, solid-state NMR, and molecular modeling.
Biophysical journal 2000;79(5):2644-56.
2000: Lindgren M; Gallet X; Soomets U; Hällbrink M; Bråkenhielm E; Pooga M; Brasseur R; Langel U
Translocation properties of novel cell penetrating transportan and penetratin analogues.
Bioconjugate chemistry 2000;11(5):619-26.
2000: Gallet X; Charloteaux B; Thomas A; Brasseur R
A fast method to predict protein interaction sites from sequences.
Journal of molecular biology 2000;302(4):917-26.
2000: Marrec-Fairley M; Piette A; Gallet X; Brasseur R; Hara H; Fraipont C; Ghuysen J M; Nguyen-Distèche M
Differential functionalities of amphiphilic peptide segments of the cell-septation penicillin-binding protein 3 of Escherichia coli.
Molecular microbiology 2000;37(5):1019-31.
2000: Liu H; Talmud P J; Lins L; Brasseur R; Olivecrona G; Peelman F; Vandekerckhove J; Rosseneu M; Labeur C
Characterization of recombinant wild type and site-directed mutations of apolipoprotein C-III: lipid binding, displacement of ApoE, and inhibition of lipoprotein lipase.
Biochemistry 2000;39(31):9201-12.
2000: Soomets U; Lindgren M; Gallet X; Hällbrink M; Elmquist A; Balaspiri L; Zorko M; Pooga M; Brasseur R; Langel U
Deletion analogues of transportan.
Biochimica et biophysica acta 2000;1467(1):165-76.
2000: Brasseur R
Tilted peptides: a motif for membrane destabilization (hypothesis).
Molecular membrane biology 2000;17(1):31-40.
1999: Lins L; Ducarme P; Breukink E; Brasseur R
Computational study of nisin interaction with model membrane.
Biochimica et biophysica acta 1999;1420(1-2):111-20.
1999: Lins L; Thomas-Soumarmon A; Pillot T; Vandekerchkhove J; Rosseneu M; Brasseur R
Molecular determinants of the interaction between the C-terminal domain of Alzheimer's beta-amyloid peptide and apolipoprotein E alpha-helices.
Journal of neurochemistry 1999;73(2):758-69.
1999: Decout A; Labeur C; Vanloo B; Goethals M; Vandekerckhove J; Brasseur R; Rosseneu M
Contribution of the hydrophobicity gradient to the secondary structure and activity of fusogenic peptides.
Molecular membrane biology 1999;16(3):237-46.
1999: Fonzé E; Vermeire M; Nguyen-Distèche M; Brasseur R; Charlier P
The crystal structure of a penicilloyl-serine transferase of intermediate penicillin sensitivity. The DD-transpeptidase of streptomyces K15.
The Journal of biological chemistry 1999;274(31):21853-60.
1999: Peuvot J; Schanck A; Lins L; Brasseur R
Are the fusion processes involved in birth, life and death of the cell depending on tilted insertion of peptides into membranes?
Journal of theoretical biology 1999;198(2):173-81.
1999: Montenez J P; Van Bambeke F; Piret J; Brasseur R; Tulkens P M; Mingeot-Leclercq M P
Interactions of macrolide antibiotics (Erythromycin A, roxithromycin, erythromycylamine [Dirithromycin], and azithromycin) with phospholipids: computer-aided conformational analysis and studies on acellular and cell culture models.
Toxicology and applied pharmacology 1999;156(2):129-40.
1999: Peelman F; Vanloo B; Perez-Mendez O; Decout A; Verschelde J L; Labeur C; Vinaimont N; Verhee A; Duverger N; Brasseur R; Vandekerckhove J; Tavernier J; Rosseneu M
Characterization of functional residues in the interfacial recognition domain of lecithin cholesterol acyltransferase (LCAT).
Protein engineering 1999;12(1):71-8.
1999: Pillot T; Goethals M; Najib J; Labeur C; Lins L; Chambaz J; Brasseur R; Vandekerckhove J; Rosseneu M
Beta-amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: relevance to Alzheimer's disease.
Journal of neurochemistry 1999;72(1):230-7.
1998: Irnaten M; Gallet X; Festy F; Péranzi G; Robert J C; Thomas-Soumarmon A; Brasseur R
Prediction of epitopes and production of monoclonal antibodies against gastric H,K-ATPase.
Protein engineering 1998;11(10):949-55.
1998: Pérez-Méndez O; Vanloo B; Decout A; Goethals M; Peelman F; Vandekerckhove J; Brasseur R; Rosseneu M
Contribution of the hydrophobicity gradient of an amphipathic peptide to its mode of association with lipids.
European journal of biochemistry / FEBS 1998;256(3):570-9.
1998: Schanck A; Peuvot J; Brasseur R
Influence of the mode of insertion of SIV peptides into membranes on the structure of model membrane as studied by 31P NMR.
Biochemical and biophysical research communications 1998;250(1):12-4.
1998: Decout A; Labeur C; Goethals M; Brasseur R; Vandekerckhove J; Rosseneu M
Enhanced efficiency of a targeted fusogenic peptide.
Biochimica et biophysica acta 1998;1372(1):102-16.
1998: Gallet X; Festy F; Ducarme P; Brasseur R; Thomas-Soumarmon A
Topological model of membrane domain of the cystic fibrosis transmembrane conductance regulator.
Journal of molecular graphics & modelling 1998;16(2):72-82, 97-8.
1998: Lambert G; Decout A; Vanloo B; Rouy D; Duverger N; Kalopissis A; Vandekerckhove J; Chambaz J; Brasseur R; Rosseneu M
The C-terminal helix of human apolipoprotein AII promotes the fusion of unilamellar liposomes and displaces apolipoprotein AI from high-density lipoproteins.
European journal of biochemistry / FEBS 1998;253(1):328-38.
1998: Ducarme P; Rahman M; Brasseur R
IMPALA: a simple restraint field to simulate the biological membrane in molecular structure studies.
Proteins 1998;30(4):357-71.
1998: Benhabilès N; Gallet X; Thomas-Soumarmon A; Brasseur R
A descriptive analysis of populations of three-dimensional structures calculated from primary sequences of proteins by OSIRIS.
Journal of computational biology : a journal of computational molecular cell biology 1998;5(2):351-66.
1997: Pillot T; Lins L; Goethals M; Vanloo B; Baert J; Vandekerckhove J; Rosseneu M; Brasseur R
The 118-135 peptide of the human prion protein forms amyloid fibrils and induces liposome fusion.
Journal of molecular biology 1997;274(3):381-93.
1997: Peelman F; Goethals M; Vanloo B; Labeur C; Brasseur R; Vandekerckhove J; Rosseneu M
Structural and functional properties of the 154-171 wild-type and variant peptides of human lecithin-cholesterol acyltransferase.
European journal of biochemistry / FEBS 1997;249(3):708-15.
1997: Brasseur R; Pillot T; Lins L; Vandekerckhove J; Rosseneu M
Peptides in membranes: tipping the balance of membrane stability.
Trends in biochemical sciences 1997;22(5):167-71.
1997: De Pauw M; Vanloo B; Dergunov A D; Devreese A M; Baert J; Brasseur R; Rosseneu M
Composition and structural and functional properties of discoidal and spherical phospholipid-apoE3 complexes.
Biochemistry. Biokhimii?a 1997;62(3):251-63.
1997: Labeur C; Lins L; Vanloo B; Baert J; Brasseur R; Rosseneu M
Design of a new class of amphipathic helical peptides for the plasma apolipoproteins that promote cellular cholesterol efflux but do not activate LCAT.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(3):580-8.
1997: Hardt K; Joris B; Lepage S; Brasseur R; Lampen J O; Frère J M; Fink A L; Ghuysen J M
The penicillin sensory transducer, BlaR, involved in the inducibility of beta-lactamase synthesis in Bacillus licheniformis is embedded in the plasma membrane via a four-alpha-helix bundle.
Molecular microbiology 1997;23(5):935-44.
1997: Pillot T; Goethals M; Vanloo B; Lins L; Brasseur R; Vandekerckhove J; Rosseneu M
Specific modulation of the fusogenic properties of the Alzheimer beta-amyloid peptide by apolipoprotein E isoforms.
European journal of biochemistry / FEBS 1997;243(3):650-9.
1996: Benetollo C; Lambert G; Talussot C; Vanloo E; Cauteren T V; Rouy D; Dubois H; Baert J; Kalopissis A; Denèfle P; Chambaz J; Brasseur R; Rosseneu M
Lipid-binding properties of synthetic peptide fragments of human apolipoprotein A-II.
European journal of biochemistry / FEBS 1996;242(3):657-64.
1996: Pillot T; Goethals M; Vanloo B; Talussot C; Brasseur R; Vandekerckhove J; Rosseneu M; Lins L
Fusogenic properties of the C-terminal domain of the Alzheimer beta-amyloid peptide.
The Journal of biological chemistry 1996;271(46):28757-65.
1996: Montenez J P; Van Bambeke F; Piret J; Schanck A; Brasseur R; Tulkens P M; Mingeot-Leclercq M P
Interaction of the macrolide azithromycin with phospholipids. II. Biophysical and computer-aided conformational studies.
European journal of pharmacology 1996;314(1-2):215-27.
1996: van Bambeke F; Mingeot-Leclercq M P; Brasseur R; Tulkens P M; Schanck A
Aminoglycoside antibiotics prevent the formation of non-bilayer structures in negatively-charged membranes. Comparative studies using fusogenic (bis(beta-diethylaminoethylether)hexestrol) and aggregating (spermine) agents.
Chemistry and physics of lipids 1996;79(2):123-35.
1995: Kotretsou S; Mingeot-Leclercq M P; Constantinou-Kokotou V; Brasseur R; Georgiadis M P; Tulkens P M
Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
Journal of medicinal chemistry 1995;38(23):4710-9.
1995: Peuvot J; Schanck A; Deleers M; Brasseur R
Piracetam-induced changes to membrane physical properties. A combined approach by 31P nuclear magnetic resonance and conformational analysis.
Biochemical pharmacology 1995;50(8):1129-34.
1995: Gallet X; Benhabiles N; Lewin M; Brasseur R; Thomas-Soumarmon A
Prediction of the antigenic sites of the cystic fibrosis transmembrane conductance regulator protein by molecular modelling.
Protein engineering 1995;8(8):829-34.
1995: Sonveaux N; Ruysschaert J M; Brasseur R
Proposition of a three-dimensional representation of the constitutive protein of the hepatitis B surface antigen particles.
Journal of protein chemistry 1995;14(6):477-86.
1995: Vanloo B; Demoor L; Boutillon C; Lins L; Brasseur R; Baert J; Fruchart J C; Tartar A; Rosseneu M
Association of synthetic peptide fragments of human apolipoprotein A-I with phospholipids.
Journal of lipid research 1995;36(8):1686-96.
1995: Van Bambeke F; Tulkens P M; Brasseur R; Mingeot-Leclercq M P
Aminoglycoside antibiotics induce aggregation but not fusion of negatively-charged liposomes.
European journal of pharmacology 1995;289(2):321-33.
1995: Mingeot-Leclercq M P; Brasseur R; Schanck A
Molecular parameters involved in aminoglycoside nephrotoxicity.
Journal of toxicology and environmental health 1995;44(3):263-300.
1994: Sonveaux N; Conrath K; Capiau C; Brasseur R; Goormaghtigh E; Ruysschaert J M
The topology of the S protein in the yeast-derived hepatitis B surface antigen particles.
The Journal of biological chemistry 1994;269(41):25637-45.
1994: Martin I; Dubois M C; Defrise-Quertain F; Saermark T; Burny A; Brasseur R; Ruysschaert J M
Correlation between fusogenicity of synthetic modified peptides corresponding to the NH2-terminal extremity of simian immunodeficiency virus gp32 and their mode of insertion into the lipid bilayer: an infrared spectroscopy study.
Journal of virology 1994;68(2):1139-48.
1994: Cabiaux V; Quertenmont P; Conrath K; Brasseur R; Capiau C; Ruysschaert J M
Topology of diphtheria toxin B fragment inserted in lipid vesicles.
Molecular microbiology 1994;11(1):43-50.
1994: Lins L; Brasseur R; Rosseneu M; Yang C Y; Sparrow D A; Sparrow J T; Gotto A M; Ruysschaert J M
Structure and orientation of apo B-100 peptides into a lipid bilayer.
Journal of protein chemistry 1994;13(1):77-88.
1993: Van Bambeke F; Mingeot-Leclercq M P; Schanck A; Brasseur R; Tulkens P M
Alterations in membrane permeability induced by aminoglycoside antibiotics: studies on liposomes and cultured cells.
European journal of pharmacology 1993;247(2):155-68.
1993: Corijn J; Deleys R; Labeur C; Vanloo B; Lins L; Brasseur R; Baert J; Ruysschaert J M; Rosseneu M
Synthetic model peptides for apolipoproteins. II. Characterization of the discoidal complexes generated between phospholipids and synthetic model peptides for apolipoproteins.
Biochimica et biophysica acta 1993;1170(1):8-16.
1993: Brasseur R; Vanloo B; Deleys R; Lins L; Labeur C; Taveirne J; Ruysschaert J M; Rosseneu M
Synthetic model peptides for apolipoproteins. I. Design and properties of synthetic model peptides for the amphipathic helices of the plasma apolipoproteins.
Biochimica et biophysica acta 1993;1170(1):1-7.
1993: Lins L; Piron S; Conrath K; Vanloo B; Brasseur R; Rosseneu M; Baert J; Ruysschaert J M
Enzymatic hydrolysis of reconstituted dimyristoylphosphatidylcholine-apo A-I complexes.
Biochimica et biophysica acta 1993;1151(2):137-42.
1993: Lins L; Brasseur R; Rosseneu M; Vanloo B; Ruysschaert J M
Structure of the apolipoprotein A-IV/lipid discoidal complexes: an attenuated total reflection polarized Fourier transform infrared spectroscopy study.
Biochimica et biophysica acta 1993;1149(2):267-77.
1993: Martin I; Defrise-Quertain F; Decroly E; Vandenbranden M; Brasseur R; Ruysschaert J M
Orientation and structure of the NH2-terminal HIV-1 gp41 peptide in fused and aggregated liposomes.
Biochimica et biophysica acta 1993;1145(1):124-33.
1992: Mingeot-Leclercq M P; Tulkens P M; Brasseur R
Accessibility of aminoglycosides, isolated and in interaction with phosphatidylinositol, to water. A conformational analysis using the concept of molecular hydrophobicity potential.
Biochemical pharmacology 1992;44(10):1967-75.
1992: Cabiaux V; Brasseur R; Mindell J; Ruysschaert J M
Computer modelling of the transmembrane channel formed by a CNBr peptide of diphtheria toxin B fragment.
FEMS microbiology immunology 1992;5(1-3):113-9.
1991: Vanloo B; Morrison J; Fidge N; Lorent G; Lins L; Brasseur R; Ruysschaert J M; Baert J; Rosseneu M
Characterization of the discoidal complexes formed between apoA-I-CNBr fragments and phosphatidylcholine.
Journal of lipid research 1991;32(8):1253-64.
1991: Van Schepdael A; Busson R; Vanderhaeghe H J; Claes P J; Verbist L; Mingeot-Leclercq M P; Brasseur R; Tulkens P M
New derivatives of kanamycin B obtained by combined modifications in positions 1 and 6". Synthesis, microbiological properties, and in vitro and computer-aided toxicological evaluation.
Journal of medicinal chemistry 1991;34(4):1483-92.
1991: Mingeot-Leclercq M P; Van Schepdael A; Brasseur R; Busson R; Vanderhaeghe H J; Claes P J; Tulkens P M
New derivatives of kanamycin B obtained by modifications and substitutions in position 6''. 2. In vitro and computer-aided toxicological evaluation with respect to interactions with phosphatidylinositol.
Journal of medicinal chemistry 1991;34(4):1476-82.
1991: Martin I; Defrise-Quertain F; Mandieau V; Nielsen N M; Saermark T; Burny A; Brasseur R; Ruysschaert J M; Vandenbranden M
Fusogenic activity of SIV (simian immunodeficiency virus) peptides located in the GP32 NH2 terminal domain.
Biochemical and biophysical research communications 1991;175(3):872-9.
1991: Brasseur R; Goormaghtigh E; Ruysschaert J M; Duquenoy P H; Marichal P; Vanden Bossche H
Lipid-itraconazole interaction in lipid model membranes.
The Journal of pharmacy and pharmacology 1991;43(3):167-71.
1990: Brasseur R; Vandenbranden M; Cornet B; Burny A; Ruysschaert J M
Orientation into the lipid bilayer of an asymmetric amphipathic helical peptide located at the N-terminus of viral fusion proteins.
Biochimica et biophysica acta 1990;1029(2):267-73.
1990: Mingeot-Leclercq M P; Piret J; Tulkens P M; Brasseur R
Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition induced by aminoglycoside antibiotics--II. Conformational analysis.
Biochemical pharmacology 1990;40(3):499-506.
1990: Mingeot-Leclercq M P; Piret J; Brasseur R; Tulkens P M
Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition by aminoglycoside antibiotics--I. Biochemical analysis.
Biochemical pharmacology 1990;40(3):489-97.
1990: Brasseur R; De Meutter J; Vanloo B; Goormaghtigh E; Ruysschaert J M; Rosseneu M
Mode of assembly of amphipathic helical segments in model high-density lipoproteins.
Biochimica et biophysica acta 1990;1043(3):245-52.
1990: Goormaghtigh E; Huart P; Praet M; Brasseur R; Ruysschaert J M
Structure of the adriamycin-cardiolipin complex. Role in mitochondrial toxicity.
Biophysical chemistry 1990;35(2-3):247-57.
1989: Goormaghtigh E; De Meutter J; Vanloo B; Brasseur R; Rosseneu M; Ruysschaert J M
Evaluation of the secondary structure of apo B-100 in low-density lipoprotein (LDL) by infrared spectroscopy.
Biochimica et biophysica acta 1989;1006(1):147-50.
1989: Cabiaux V; Brasseur R; Wattiez R; Falmagne P; Ruysschaert J M; Goormaghtigh E
Secondary structure of diphtheria toxin and its fragments interacting with acidic liposomes studied by polarized infrared spectroscopy.
The Journal of biological chemistry 1989;264(9):4928-38.
1989: Mingeot-Leclercq M P; Schanck A; Ronveaux-Dupal M F; Deleers M; Brasseur R; Ruysschaert J M; Laurent G; Tulkens P M
Ultrastructural, physico-chemical and conformational study of the interactions of gentamicin and bis(beta-diethylaminoethylether) hexestrol with negatively-charged phospholipid layers.
Biochemical pharmacology 1989;38(5):729-41.
1989: Goormaghtigh E; Martin I; Vandenbranden M; Brasseur R; Ruysschaert J M
Secondary structure and orientation of a chemically synthesized mitochondrial signal sequence in phospholipid bilayers.
Biochemical and biophysical research communications 1989;158(2):610-6.
1988: Brasseur R; Lorge P; Goormaghtigh E; Ruysschaert J M; Espion D; Burny A
The mode of insertion of the paramyxovirus F1 N-terminus into lipid matrix, an initial step in host cell/virus fusion.
Virus genes 1988;1(4):325-32.
1988: Schepers H; Brasseur R; Goormaghtigh E; Duquenoy P; Ruysschaert J M
Mode of insertion of praziquantel and derivatives into lipid membranes.
Biochemical pharmacology 1988;37(8):1615-23.
1988: Brasseur R; Cornet B; Burny A; Vandenbranden M; Ruysschaert J M
Mode of insertion into a lipid membrane of the N-terminal HIV gp41 peptide segment.
AIDS research and human retroviruses 1988;4(2):83-90.
1987: Goormaghtigh E; Brasseur R; Huart P; Ruysschaert J M
Study of the adriamycin-cardiolipin complex structure using attenuated total reflection infrared spectroscopy.
Biochemistry 1987;26(6):1789-94.
1986: Goormaghtigh E; Huart P; Brasseur R; Ruysschaert J M
Mechanism of inhibition of mitochondrial enzymatic complex I-III by adriamycin derivatives.
Biochimica et biophysica acta 1986;861(1):83-94.
1984: Huart P; Brasseur R; Goormaghtigh E; Ruysschaert J M
Antimitotics induce cardiolipin cluster formation. Possible role in mitochondrial enzyme inactivation.
Biochimica et biophysica acta 1984;799(2):199-202.
1983: Brasseur R; De Meutter J; Goormaghtigh E; Ruysschaert J M
Mode of organization of galactolipids: a conformational analysis.
Biochemical and biophysical research communications 1983;115(2):666-72.

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