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Milton Werner

Research Profile

Chemicals & Drugs

Concepts & Ideas

Phenomena

Genes & Molecular Sequences

Amino Acid Sequences

Physiology

Transcription, Genetic

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Publications

TOP 3
Tobias Berg; Manfred Fliegauf; Jan Burger; Martin S Staege; Shaohua Liu; Natalia Martinez; Olaf Heidenreich; Stefan Burdach; Torsten Haferlach; Milton H Werner; Michael Lübbert
Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO.
Richard P Bonocora; Gregori Caignan; Christopher Woodrell; Milton H Werner; Deborah M Hinton
A basic/hydrophobic cleft of the T4 activator MotA interacts with the C-terminus of E.coli sigma70 to activate middle gene transcription.
Yufeng Wei; Shaohua Liu; Jörn Lausen; Christopher Woodrell; Seongeun Cho; Nikolaos Biris; Naohiro Kobayashi; Yu Wei; Shigeyuki Yokoyama; Milton H Werner
A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription.

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All Publications

2008: Tobias Berg; Manfred Fliegauf; Jan Burger; Martin S Staege; Shaohua Liu; Natalia Martinez; Olaf Heidenreich; Stefan Burdach; Torsten Haferlach; Milton H Werner; Michael Lübbert
Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO.
Haematologica 2008;93(11):1728-33.
2008: Richard P Bonocora; Gregori Caignan; Christopher Woodrell; Milton H Werner; Deborah M Hinton
A basic/hydrophobic cleft of the T4 activator MotA interacts with the C-terminus of E.coli sigma70 to activate middle gene transcription.
Molecular microbiology 2008;69(2):331-43.
2007: Yufeng Wei; Shaohua Liu; Jörn Lausen; Christopher Woodrell; Seongeun Cho; Nikolaos Biris; Naohiro Kobayashi; Yu Wei; Shigeyuki Yokoyama; Milton H Werner
A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription.
Nature structural & molecular biology 2007;14(7):653-61.
2007: Milton H Werner
NIH funding: what does the future look like?
Science (New York, N.Y.) 2007;316(5822):198-200; author reply 198-200.
2006: Cristinel Sandu; Gaku Morisawa; Iga N Wegorzewska; Ted Huang; Adrian F Arechiga; Justine M Hill; T Kim; Craig M Walsh; Milton H Werner
FADD self-association is required for stable interaction with an activated death receptor.
Cell death and differentiation 2006;13(12):2052-61.
2006: Milton H Werner; Chaowei Wu; Craig M Walsh
Emerging roles for the death adaptor FADD in death receptor avidity and cell cycle regulation.
Cell cycle (Georgetown, Tex.) 2006;5(20):2332-8.
2006: Paul E Carrington; Cristinel Sandu; Yufeng Wei; Justine M Hill; Gaku Morisawa; Ted Huang; Evripidis Gavathiotis; Yu Wei; Milton H Werner
The structure of FADD and its mode of interaction with procaspase-8.
Molecular cell 2006;22(5):599-610.
2006: Yufeng Wei; Milton H Werner
iDC: A comprehensive toolkit for the analysis of residual dipolar couplings for macromolecular structure determination.
Journal of biomolecular NMR 2006;35(1):17-25.
2006: Jörn Lausen; Shaohua Liu; Manfred Fliegauf; Michael Lübbert; Milton H Werner
ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO.
Oncogene 2006;25(9):1349-57.
2005: Cristinel Sandu; Evripidis Gavathiotis; Ted Huang; Iga N Wegorzewska; Milton H Werner
A mechanism for death receptor discrimination by death adaptors.
The Journal of biological chemistry 2005;280(36):31974-80.
2004: Jörn Lausen; Seongeun Cho; Shaohua Liu; Milton H Werner
The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO.
The Journal of biological chemistry 2004;279(47):49281-8.
2004: Lester J Lambert; Yufeng Wei; Virgil Schirf; Borries Demeler; Milton H Werner
T4 AsiA blocks DNA recognition by remodeling sigma70 region 4.
The EMBO journal 2004;23(15):2952-62.
2004: Justine M Hill; Gaku Morisawa; Tad Kim; Ted Huang; Yu Wei; Yufeng Wei; Milton H Werner
Identification of an expanded binding surface on the FADD death domain responsible for interaction with CD95/Fas.
The Journal of biological chemistry 2004;279(2):1474-81.
2003: Fan-Li Chou; Justine M Hill; Jyh-Cheng Hsieh; Jacques Pouyssegur; Anne Brunet; Angela Glading; Florian Uberall; Joe W Ramos; Milton H Werner; Mark H Ginsberg
PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation.
The Journal of biological chemistry 2003;278(52):52587-97.
2003: Lester J Lambert; Virgil Schirf; Borries Demeler; Milton H Werner
Molecular analysis of activator engagement with RNA polymerase.
Methods in enzymology 2003;370():505-21.
2002: Justine M Hill; Hema Vaidyanathan; Joe W Ramos; Mark H Ginsberg; Milton H Werner
Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain.
The EMBO journal 2002;21(23):6494-504.
2001: Lester J Lambert; Virgil Schirf; Borries Demeler; Martine Cadene; Milton H Werner
Flipping a genetic switch by subunit exchange.
The EMBO journal 2001;20(24):7149-59.
2001: T Nagata; Milton H Werner
Functional mutagenesis of AML1/RUNX1 and PEBP2 beta/CBF beta define distinct, non-overlapping sites for DNA recognition and heterodimerization by the Runt domain.
Journal of molecular biology 2001;308(2):191-203.
2001: Milton H Werner; Vineet Gupta; Lester J Lambert; T Nagata
Uniform 13C/15N-labeling of DNA by tandem repeat amplification.
Methods in enzymology 2001;338():283-304.
1999: Milton H Werner; Shigesada Katsuya; Y Ito
Runt domains take the lead in hematopoiesis and osteogenesis.
Nature medicine 1999;5(12):1356-7.
1999: Mike Goger; Vineet Gupta; W Y Kim; Shigesada Katsuya; Y Ito; Milton H Werner
Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta.
Nature structural biology 1999;6(7):620-3.
1999: T Nagata; Vineet Gupta; D Sorce; W Y Kim; Andrej Sali; Brian T Chait; Shigesada Katsuya; Y Ito; Milton H Werner
Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain.
Nature structural biology 1999;6(7):615-9.
1998: Caroline M Groft; SN Uljon; Runsheng Wang; Milton H Werner
Structural homology between the Rap30 DNA-binding domain and linker histone H5: implications for preinitiation complex assembly.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9117-22.
1997: Milton H Werner; G M Clore; C L Fisher; R J Fisher; Loc Ba Trinh; J Shiloach; A M Gronenborn
Correction of the NMR structure of the ETS1/DNA complex.
Journal of biomolecular NMR 1997;10(4):317-28.
1997: Milton H Werner; A M Gronenborn; G M Clore
ETS1-DNA binding and intercalation: correction.
Science (New York, N.Y.) 1997;276(5321):1957.
1997: Milton H Werner; Stephen K Burley
Architectural transcription factors: proteins that remodel DNA.
Cell 1997;88(6):733-6.
1996: Milton H Werner
Stopping death cold.
Structure (London, England : 1993) 1996;4(8):879-83.
1996: Milton H Werner; J R Huth; Angela M Gronenborn; G Marius Clore
Molecular determinants of mammmalian sex.
Trends in biochemical sciences 1996;21(8):302-8.
1996: Milton H Werner; Angela M Gronenborn; G Marius Clore
Intercalation, DNA kinking, and the control of transcription.
Science (New York, N.Y.) 1996;271(5250):778-84.
1995: Milton H Werner; M Clore; C L Fisher; Robert J Fisher; Loc Ba Trinh; Joseph Shiloach; Angela M Gronenborn
The solution structure of the human ETS1-DNA complex reveals a novel mode of binding and true side chain intercalation.
Cell 1995;83(5):761-71.
1995: Milton H Werner; M E Bianchi; Angela M Gronenborn; G Marius Clore
NMR spectroscopic analysis of the DNA conformation induced by the human testis determining factor SRY.
Biochemistry 1995;34(37):11998-2004.
1995: Milton H Werner; J R Huth; Angela M Gronenborn; G Marius Clore
Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex.
Cell 1995;81(5):705-14.
1994: Milton H Werner; G Marius Clore; Angela M Gronenborn; Howard A Nash
Symmetry and asymmetry in the function of Escherichia coli integration host factor: implications for target identification by DNA-binding proteins.
Current biology : CB 1994;4(6):477-87.
1994: Milton H Werner; G Marius Clore; Angela M Gronenborn; A Kondoh; Robert J Fisher
Refolding proteins by gel filtration chromatography.
FEBS letters 1994;345(2-3):125-30.
1992: Milton H Werner; David E Wemmer
Identification of a protein-binding surface by differential amide hydrogen-exchange measurements. Application to Bowman-Birk serine-protease inhibitor.
Journal of molecular biology 1992;225(3):873-89.
1992: Milton H Werner; David E Wemmer
Three-dimensional structure of soybean trypsin/chymotrypsin Bowman-Birk inhibitor in solution.
Biochemistry 1992;31(4):999-1010.
1991: Milton H Werner; David E Wemmer
1H assignments and secondary structure determination of the soybean trypsin/chymotrypsin Bowman-Birk inhibitor.
Biochemistry 1991;30(14):3356-64.