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Zalfa Abdel-Malek

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Anatomy

Chemicals & Drugs

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Ultraviolet Rays

Disorders

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Viki B Swope; George F Babcock; Joshua A Jameson; Kevin L McFarland; Dennis W McGraw; William E Miller; Glenn L Millhauser; Matthew A Nix; Mira A Patel; Dorothy M Supp; Zalfa A Abdel-Malek
Defining MC1R regulation in human melanocytes by its agonist α-melanocortin and antagonists agouti signaling protein and β-defensin 3.
Ana Luisa Kadekaro; Viki B Swope; Jennifer Yang; Juping Chen; Shuna Chen; Tan Cheng; Joshua Jameson; Madhavi Kadakia; Zalfa A Abdel-Malek
Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes.
Zalfa A Abdel-Malek; Menashe Bar-Eli
Estela Medrano, 1943-2010.

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2012: Viki B Swope; George F Babcock; Joshua A Jameson; Kevin L McFarland; Dennis W McGraw; William E Miller; Glenn L Millhauser; Matthew A Nix; Mira A Patel; Dorothy M Supp; Zalfa A Abdel-Malek
Defining MC1R regulation in human melanocytes by its agonist α-melanocortin and antagonists agouti signaling protein and β-defensin 3.
The Journal of investigative dermatology 2012;132(9):2255-62.
2012: Ana Luisa Kadekaro; Viki B Swope; Jennifer Yang; Juping Chen; Shuna Chen; Tan Cheng; Joshua Jameson; Madhavi Kadakia; Zalfa A Abdel-Malek
Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes.
Molecular cancer research : MCR 2012;10(6):778-86.
2010: Zalfa A Abdel-Malek; Menashe Bar-Eli
Estela Medrano, 1943-2010.
Pigment cell & melanoma research 2010;23(6):724.
2010: Ana Luisa Kadekaro; Sancy Leachman; Renny Kavanagh; Viki B Swope; Pamela Cassidy; Dorothy M Supp; Maureen Sartor; Sandy Schwemberger; George Babcock; Kazumasa Wakamatsu; Shosuke Ito; Amy Koshoffer; Raymond E Boissy; Prashiela Manga; Richard A Sturm; Zalfa A Abdel-Malek
Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(10):3850-60.
2010: Renny J Starner; Lindy McClelland; Zalfa A Abdel-Malek; Alex Fricke; Glynis Scott
PGE(2) is a UVR-inducible autocrine factor for human melanocytes that stimulates tyrosinase activation.
Experimental dermatology 2010;19(7):682-4.
2010: Zalfa A Abdel-Malek; Ana Luisa Kadekaro; Viki B Swope
Stepping up melanocytes to the challenge of UV exposure.
Pigment cell & melanoma research 2010;23(2):171-86.
2010: Zalfa A Abdel-Malek
Development of α-melanocortin analogs for melanoma prevention and targeting.
Advances in experimental medicine and biology 2010;681():126-32.
2009: Xiuzu Song; Nicole Mosby; Jennifer Yang; Aie Xu; Zalfa A Abdel-Malek; Ana Luisa Kadekaro
alpha-MSH activates immediate defense responses to UV-induced oxidative stress in human melanocytes.
Pigment cell & melanoma research 2009;22(6):809-18.
2009: Zalfa A Abdel-Malek; Andrew Ruwe; Renny Kavanagh-Starner; Ana Luisa Kadekaro; Viki B Swope; Carrie Haskell-Luevano; Leonid Koikov; James J Knittel
alpha-MSH tripeptide analogs activate the melanocortin 1 receptor and reduce UV-induced DNA damage in human melanocytes.
Pigment cell & melanoma research 2009;22(5):635-44.
2009: Andrew R Ruwe; Leonid Koikov; Zalfa A Abdel-Malek; Carrie Haskell-Luevano; Marvin L Dirain; Federico Portillo; Zhimin Xiang; matthew d wortman; James J Knittel
Semi-rigid tripeptide agonists of melanocortin receptors.
Bioorganic & medicinal chemistry letters 2009;19(17):5176-81.
2009: Zalfa A Abdel-Malek
Agouti signal protein: crossing the 'yellow' signal and arriving to pathways that affect tumorgenesis.
Pigment cell & melanoma research 2009;22(3):253-4.
2008: Zalfa A Abdel-Malek; James J Knittel; Ana Luisa Kadekaro; Viki B Swope; Renny Starner
The melanocortin 1 receptor and the UV response of human melanocytes--a shift in paradigm.
Photochemistry and photobiology 2008;84(2):501-8.
2008: Zalfa A Abdel-Malek; Dorothy Supp
beta-Defensin 3: a novel and unexpected key that unlocks the melanocortin 1 receptor.
Pigment cell & melanoma research 2008;21(1):7-8.
2007: Ana Luisa Kadekaro; Zalfa A Abdel-Malek
Walking in the footsteps of giants: melanocortins and human pigmentation, a historical perspective.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2007;20(3):150-2.
2006: Francois Rouzaud; Gertrude-E Costin; Yuji Yamaguchi; Julio C Valencia; Werner Berens; Kevin Gang Chen; Toshihiko Hoashi; Markus Böhm; Zalfa A Abdel-Malek; Vincent J Hearing
Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1 receptor isoforms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(11):1927-9.
2006: Jennifer E Hauser; Ana Luisa Kadekaro; Renny Kavanagh; Kazumasa Wakamatsu; Silva Terzieva; Sandy Schwemberger; George Babcock; M B Rao; Shosuke Ito; Zalfa A Abdel-Malek
Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2006;19(4):303-14.
2006: Zalfa A Abdel-Malek; Ana Luisa Kadekaro; Renny Kavanagh; Aleksandar Todorovic; Leonid N Koikov; Joseph McNulty; Pilgrim J Jackson; Glenn L Millhauser; Sandy Schwemberger; George Babcock; Carrie Haskell-Luevano; James J Knittel
Melanoma prevention strategy based on using tetrapeptide alpha-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(9):1561-3.
2006: Kazumasa Wakamatsu; Renny Kavanagh; Ana Luisa Kadekaro; Silva Terzieva; Richard A Sturm; Sancy A Leachman; Zalfa A Abdel-Malek; Shosuke Ito
Diversity of pigmentation in cultured human melanocytes is due to differences in the type as well as quantity of melanin.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2006;19(2):154-62.
2006: Ana Luisa Kadekaro; Kazumasa Wakamatsu; Shosuke Ito; Zalfa A Abdel-Malek
Cutaneous photoprotection and melanoma susceptibility: reaching beyond melanin content to the frontiers of DNA repair.
Frontiers in bioscience : a journal and virtual library 2006;11():2157-73.
2005: Ana Luisa Kadekaro; Renny Kavanagh; Hiromi Kanto; Silva Terzieva; Jennifer Hauser; Nobuhiko Kobayashi; Sandy Schwemberger; James Cornelius; George Babcock; Howard G Shertzer; Glynis Scott; Zalfa A Abdel-Malek
alpha-Melanocortin and endothelin-1 activate antiapoptotic pathways and reduce DNA damage in human melanocytes.
Cancer research 2005;65(10):4292-9.
2005: Aleksandar Todorovic; Jerry Ryan Holder; Rayna M Bauzo; Joseph W Scott; Renny Kavanagh; Zalfa A Abdel-Malek; Carrie Haskell-Luevano
N-terminal fatty acylated His-dPhe-Arg-Trp-NH(2) tetrapeptides: influence of fatty acid chain length on potency and selectivity at the mouse melanocortin receptors and human melanocytes.
Journal of medicinal chemistry 2005;48(9):3328-36.
2005: Francois Rouzaud; Ana Luisa Kadekaro; Zalfa A Abdel-Malek; Vincent J Hearing
MC1R and the response of melanocytes to ultraviolet radiation.
Mutation research 2005;571(1-2):133-52.
2004: Yuji Yamaguchi; Satoshi Itami; Hidenori Watabe; Ken-ichi Yasumoto; Zalfa A Abdel-Malek; Tateki Kubo; Francois Rouzaud; Atsushi Tanemura; Kunihiko Yoshikawa; Vincent J Hearing
Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation.
The Journal of cell biology 2004;165(2):275-85.
2003: Ana Luisa Kadekaro; Renny Kavanagh; Kazumasa Wakamatsu; Shosuke Ito; Michelle A Pipitone; Zalfa A Abdel-Malek
Cutaneous photobiology. The melanocyte vs. the sun: who will win the final round?
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2003;16(5):434-47.
2003: Ana Luisa Kadekaro; Hiromi Kanto; Renny Kavanagh; Zalfa A Abdel-Malek
Significance of the melanocortin 1 receptor in regulating human melanocyte pigmentation, proliferation, and survival.
Annals of the New York Academy of Sciences 2003;994():359-65.
2002: M Cathy Scott; Itaru Suzuki; Zalfa A Abdel-Malek
Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors and by ultraviolet radiation.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2002;15(6):433-9.
2002: M Cathy Scott; Kazumasa Wakamatsu; Shosuke Ito; Ana Luisa Kadekaro; Nobuhiko Kobayashi; Joanna Groden; Renny Kavanagh; Takako Takakuwa; Victoria Virador; Vincent J Hearing; Zalfa A Abdel-Malek
Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation.
Journal of cell science 2002;115(Pt 11):2349-55.
2002: Akihiro Tada; Elizabeth Pereira; Dana Beitner-Johnson; Renny Kavanagh; Zalfa A Abdel-Malek
Mitogen- and ultraviolet-B-induced signaling pathways in normal human melanocytes.
The Journal of investigative dermatology 2002;118(2):316-22.
2002: Victoria Virador; Jacqueline Muller; Xufneg Wu; Zalfa A Abdel-Malek; Zu-Xi Yu; Victor J Ferrans; Nobuhiko Kobayashi; Kazumasa Wakamatsu; Shosuke Ito; John A Hammer; Vincent J Hearing
Influence of alpha-melanocyte-stimulating hormone and ultraviolet radiation on the transfer of melanosomes to keratinocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(1):105-7.
2001: Zalfa A Abdel-Malek
Neuromediators and pigmentation.
Experimental dermatology 2001;10(5):350-1.
2001: Victoria Virador; N Matsunaga; J Matsunaga; Julio C Valencia; R J Oldham; K Kameyama; G L Peck; Victor J Ferrans; Wilfred D Vieira; Zalfa A Abdel-Malek; Vincent J Hearing
Production of melanocyte-specific antibodies to human melanosomal proteins: expression patterns in normal human skin and in cutaneous pigmented lesions.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2001;14(4):289-97.
2001: Zalfa A Abdel-Malek
Melanocortin receptors: their functions and regulation by physiological agonists and antagonists.
Cellular and molecular life sciences : CMLS 2001;58(3):434-41.
2001: Zalfa A Abdel-Malek; M Cathy Scott; Minao Furumura; M Lynn Lamoreux; MM Ollmann; Gregory S Barsh; Vincent J Hearing
The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes.
Journal of cell science 2001;114(Pt 5):1019-24.
2000: Zalfa A Abdel-Malek; M Cathy Scott; Itaru Suzuki; Akihiro Tada; S Im; L Lamoreux; Shosuke Ito; Gregory S Barsh; Vincent J Hearing
The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2000;13 Suppl 8():156-62.
1999: Fan Yang; Zalfa A Abdel-Malek; Raymond E Boissy
Effects of commonly used mitogens on the cytotoxicity of 4-tertiary butylphenol to human melanocytes.
In vitro cellular & developmental biology. Animal 1999;35(10):566-70.
1999: Zalfa A Abdel-Malek; Itaru Suzuki; Akihiro Tada; S Im; C Akcali
The melanocortin-1 receptor and human pigmentation.
Annals of the New York Academy of Sciences 1999;885():117-33.
1999: Itaru Suzuki; S Im; Akihiro Tada; C Scott; C Akcali; M B Davis; Gregory S Barsh; Vincent J Hearing; Zalfa A Abdel-Malek
Participation of the melanocortin-1 receptor in the UV control of pigmentation.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1999;4(1):29-34.
1998: G Can; Zalfa A Abdel-Malek; P A Porter-Gill; P Gill; Steven Boyce; Gregory A Grabowski; James J Nordlund; J Farooqui
Identification and sequencing of a putative variant of proopiomelanocortin in human epidermis and epidermal cells in culture.
The Journal of investigative dermatology 1998;111(3):485-91.
1998: Akihiro Tada; Itaru Suzuki; S Im; M B Davis; James Cornelius; George Babcock; James J Nordlund; Zalfa A Abdel-Malek
Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(7):575-84.
1998: S Im; O Moro; F Peng; E E Medrano; James Cornelius; George Babcock; James J Nordlund; Zalfa A Abdel-Malek
Activation of the cyclic AMP pathway by alpha-melanotropin mediates the response of human melanocytes to ultraviolet B radiation.
Cancer research 1998;58(1):47-54.
1997: C Sakai; MM Ollmann; Takeshi Kobayashi; Zalfa A Abdel-Malek; Jacqueline Muller; Wilfred D Vieira; G Imokawa; Gregory S Barsh; Vincent J Hearing
Modulation of murine melanocyte function in vitro by agouti signal protein.
The EMBO journal 1997;16(12):3544-52.
1997: Itaru Suzuki; Akihiro Tada; MM Ollmann; Gregory S Barsh; S Im; M Lynn Lamoreux; Vincent J Hearing; James J Nordlund; Zalfa A Abdel-Malek
Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to alpha-melanotropin.
The Journal of investigative dermatology 1997;108(6):838-42.
1996: Itaru Suzuki; R D Cone; S Im; James J Nordlund; Zalfa A Abdel-Malek
Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis.
Endocrinology 1996;137(5):1627-33.
1995: Estela E Medrano; S Im; Fan Yang; Zalfa A Abdel-Malek
Ultraviolet B light induces G1 arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long-term expression of the p21Waf-1/SDI-1/Cip-1 protein.
Cancer research 1995;55(18):4047-52.
1995: D Barker; Kathleen Dixon; Estela E Medrano; D Smalara; S Im; D Mitchell; George Babcock; Zalfa A Abdel-Malek
Comparison of the responses of human melanocytes with different melanin contents to ultraviolet B irradiation.
Cancer research 1995;55(18):4041-6.
1995: Viki B Swope; Estela E Medrano; D Smalara; Zalfa A Abdel-Malek
Long-term proliferation of human melanocytes is supported by the physiologic mitogens alpha-melanotropin, endothelin-1, and basic fibroblast growth factor.
Experimental cell research 1995;217(2):453-9.
1995: Zalfa A Abdel-Malek; Viki B Swope; Itaru Suzuki; C Akcali; MD Harriger; Steven T Boyce; K Urabe; Vincent J Hearing
Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1789-93.
1994: Zalfa A Abdel-Malek; Viki B Swope; D Smalara; George Babcock; S Dawes; James J Nordlund
Analysis of the UV-induced melanogenesis and growth arrest of human melanocytes.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1994;7(5):326-32.
1994: H Zhao; Y L Boissy; Zalfa A Abdel-Malek; Richard A King; James J Nordlund; Raymond E Boissy
On the analysis of the pathophysiology of Chediak-Higashi syndrome. Defects expressed by cultured melanocytes.
Laboratory investigation; a journal of technical methods and pathology 1994;71(1):25-34.
1994: Viki B Swope; D N Sauder; R C McKenzie; R M Sramkoski; K A Krug; George Babcock; James J Nordlund; Zalfa A Abdel-Malek
Synthesis of interleukin-1 alpha and beta by normal human melanocytes.
The Journal of investigative dermatology 1994;102(5):749-53.
1994: Zalfa A Abdel-Malek; Viki B Swope; James J Nordlund; Estela E Medrano
Proliferation and propagation of human melanocytes in vitro are affected by donor age and anatomical site.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1994;7(2):116-22.
1993: Zalfa A Abdel-Malek; Viki B Swope; C Collins; Raymond E Boissy; H Zhao; James J Nordlund
Contribution of melanogenic proteins to the heterogeneous pigmentation of human melanocytes.
Journal of cell science 1993;106 ( Pt 4)():1323-31.
1993: J Z Farooqui; Estela E Medrano; Zalfa A Abdel-Malek; James J Nordlund
The expression of proopiomelanocortin and various POMC-derived peptides in mouse and human skin.
Annals of the New York Academy of Sciences 1993;680():508-10.
1993: Steven T Boyce; Estela E Medrano; Zalfa A Abdel-Malek; Andrew P Supp; J M Dodick; James J Nordlund; G D Warden
Pigmentation and inhibition of wound contraction by cultured skin substitutes with adult melanocytes after transplantation to athymic mice.
The Journal of investigative dermatology 1993;100(4):360-5.
1992: Zalfa A Abdel-Malek; Viki B Swope; J Pallas; K Krug; James J Nordlund
Mitogenic, melanogenic, and cAMP responses of cultured neonatal human melanocytes to commonly used mitogens.
Journal of cellular physiology 1992;150(2):416-25.
1992: Zalfa A Abdel-Malek; Viki B Swope; James J Nordlund
The nature and biological effects of factors responsible for proliferation and differentiation of melanocytes.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1992;Suppl 2():43-7.
1991: P I Plews; Zalfa A Abdel-Malek; C A Doupnik; George Leikauf
Endothelin stimulates chloride secretion across canine tracheal epithelium.
The American journal of physiology 1991;261(2 Pt 1):L188-94.
1991: Viki B Swope; Zalfa A Abdel-Malek; L M Kassem; James J Nordlund
Interleukins 1 alpha and 6 and tumor necrosis factor-alpha are paracrine inhibitors of human melanocyte proliferation and melanogenesis.
The Journal of investigative dermatology 1991;96(2):180-5.
1989: James J Nordlund; Zalfa A Abdel-Malek; Raymond E Boissy; L A Rheins
Pigment cell biology: an historical review.
The Journal of investigative dermatology 1989;92(4 Suppl):53S-60S.
1989: Viki B Swope; Zalfa A Abdel-Malek; D N Sauder; James J Nordlund
A new role for epidermal cell-derived thymocyte activating factor/IL-1 as an antagonist for distinct epidermal cell function.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(6):1943-9.
1989: Zalfa A Abdel-Malek; Viki B Swope; L S Trinkle; James J Nordlund
Stimulation of Cloudman melanoma tyrosinase activity occurs predominantly in G2 phase of the cell cycle.
Experimental cell research 1989;180(1):198-208.
1988: L S Trinkle; Viki B Swope; Zalfa A Abdel-Malek; James J Nordlund
Differentiation of mitotic melanoma cells from G2 cells and their isolation by use of 5-bromo-2'-deoxyuridine and propidium iodide.
Cytometry 1988;9(5):432-5.
1988: Zalfa A Abdel-Malek; Viki B Swope; L S Trinkle; Elisabeth Schwartz; Raymond E Boissy; James J Nordlund
Alteration of the Cloudman melanoma cell cycle by prostaglandins E1 and E2 determined by using a 5-bromo-2'-deoxyuridine method of DNA analysis.
Journal of cellular physiology 1988;136(2):247-56.
1988: Zalfa A Abdel-Malek; R Ross; L Trinkle; Viki B Swope; J W Pike; James J Nordlund
Hormonal effects of vitamin D3 on epidermal melanocytes.
Journal of cellular physiology 1988;136(2):273-80.
1988: Zalfa A Abdel-Malek
Endocrine factors as effectors of integumental pigmentation.
Dermatologic clinics 1988;6(2):175-83.
1988: James J Nordlund; Zalfa A Abdel-Malek
Mechanisms for post-inflammatory hyperpigmentation and hypopigmentation.
Progress in clinical and biological research 1988;256():219-36.
1987: Zalfa A Abdel-Malek; Viki B Swope; N Amornsiripanitch; James J Nordlund
In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins.
Cancer research 1987;47(12):3141-6.