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Rudi Westendorp

Research Profile

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TOP 3
David Nanchen; Nicolas Rodondi; Naveed Sattar; David J Stott; Rudi G J Westendorp; Brendan M Buckley; Jacques Cornuz; Anton J M de Craen; Ian Ford; Jacobijn Gussekloo; J Wouter Jukema; Peter W Macfarlane; Simon P Mooijaart
Resting heart rate and incident heart failure and cardiovascular mortality in older adults: role of inflammation and endothelial dysfunction: the PROSPER study.
Rosalinde K E Poortvliet; Rudi G J Westendorp; Jacobijn Gussekloo; Simon P Mooijaart; Willem J J Assendelft; Jeanet W Blom; Anton J M de Craen; Wouter de Ruijter
Low blood pressure predicts increased mortality in very old age even without heart failure: the Leiden 85-plus Study.
Anna G C Boef; Andrea B Maier; Linda May; David van Bodegom; Lisette van Lieshout; Jaco J Verweij; Rudi G J Westendorp; Ulrika K Eriksson
Parasitic infections and immune function: effect of helminth infections in a malaria endemic area.

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All Publications

2013: David Nanchen; Nicolas Rodondi; Naveed Sattar; David J Stott; Rudi G J Westendorp; Brendan M Buckley; Jacques Cornuz; Anton J M de Craen; Ian Ford; Jacobijn Gussekloo; J Wouter Jukema; Peter W Macfarlane; Simon P Mooijaart
Resting heart rate and incident heart failure and cardiovascular mortality in older adults: role of inflammation and endothelial dysfunction: the PROSPER study.
European journal of heart failure 2013;15(5):581-8.
2013: Rosalinde K E Poortvliet; Rudi G J Westendorp; Jacobijn Gussekloo; Simon P Mooijaart; Willem J J Assendelft; Jeanet W Blom; Anton J M de Craen; Wouter de Ruijter
Low blood pressure predicts increased mortality in very old age even without heart failure: the Leiden 85-plus Study.
European journal of heart failure 2013;15(5):528-33.
2013: Anna G C Boef; Andrea B Maier; Linda May; David van Bodegom; Lisette van Lieshout; Jaco J Verweij; Rudi G J Westendorp; Ulrika K Eriksson
Parasitic infections and immune function: effect of helminth infections in a malaria endemic area.
Immunobiology 2013;218(5):706-11.
2013: Carolien A Wijsman; Anton J M de Craen; Evelien S Hoogeveen; Andrea B Maier; Hanno Pijl; P Eline Slagboom; Frans van der Ouderaa; Diana van Heemst; Rudi G J Westendorp; Simon P Mooijaart
Ambulant 24-h glucose rhythms mark calendar and biological age in apparently healthy individuals.
Aging cell 2013;12(2):207-13.
2013: Mette Soerensen; Tinna Stevnsner; H Eka D Suchiman; Qihua Tan; Mikael Thinggaard; James W Vaupel; Rudi G J Westendorp; Marian Beekman; Vilhelm A Bohr; Kaare Christensen; Serena Dato; Anton J M de Craen; Rune Jacobsen; Rabea Kleindorp; Matt McGue; Almut Nebel; Stefan Schreiber; P Eline Slagboom; Lene Christiansen
Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.
Age (Dordrecht, Netherlands) 2013;35(2):487-500.
2013: Wendy P J den Elzen; Dorine W Swinkels; Rudi G J Westendorp; Erwin T G Wiegerinck; Anton J M de Craen; Jacobijn Gussekloo
Plasma hepcidin levels and anemia in old age. The Leiden 85-Plus Study.
Haematologica 2013;98(3):448-54.
2013: Iris Postmus; Naveed Sattar; P Eline Slagboom; David J Stott; Stella Trompet; Rudi G J Westendorp; Brendan M Buckley; Anton J M de Craen; Ian Ford; J Wouter Jukema
PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population.
Journal of lipid research 2013;54(2):561-6.
2013: David A Gunn; Andrea B Maier; Peter G Murray; Stephanie Ogden; P Eline Slagboom; Cyrena C Tomlin; Diana van Heemst; Sharon D Catt; Anton J M de Craen; Joanne L Dick; Christopher E M Griffiths; Tamara Griffiths; Rudi G J Westendorp
Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals.
The journals of gerontology. Series A, Biological sciences and medical sciences 2013;68(2):145-52.
2013: Joris Deelen; Jelle J Goeman; Jeanine J Houwing-Duistermaat; Ramin Monajemi; Fernando Rivadeneira; P Eline Slagboom; Peter E Thijssen; Hae-Won Uh; André G Uitterlinden; Erik B van den Akker; Diana van Heemst; Rudi G J Westendorp; Stefan Boehringer; Anton J M de Craen; Marian Beekman
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.
Age (Dordrecht, Netherlands) 2013;35(1):235-49.
2013: Raymond Noordam; P Eline Slagboom; Cyrena C Tomlin; Diana van Heemst; Rudi G J Westendorp; Anton J M de Craen; David A Gunn; Andrea B Maier; Simon P Mooijaart
High serum glucose levels are associated with a higher perceived age.
Age (Dordrecht, Netherlands) 2013;35(1):189-95.
2013: Liselotte W Wijsman; Anton J M de Craen; Jacobijn Gussekloo; J Wouter Jukema; Nicolas Rodondi; David J Stott; Stella Trompet; Paul Welsh; Rudi G J Westendorp; Simon P Mooijaart
Subclinical thyroid dysfunction and cognitive decline in old age.
PloS one 2013;8(3):e59199.
2013: Marjon Stijntjes; Mark A Van Buchem; Diana van Heemst; Rudi G J Westendorp; Anton J M de Craen; Carel G M Meskers; P Eline Slagboom; Andrea B Maier
Familial longevity is marked by better cognitive performance at middle age: the Leiden Longevity Study.
PloS one 2013;8(3):e57962.
2013: Willemien van de Water; Rudi G J Westendorp; Esther Bastiaannet; Anton J M de Craen; Annette Hasenburg; Elysée T M Hille; Steve E Jones; Christos Markopoulos; Robert Paridaens; Hein Putter; Daniel Rea; Caroline Seynaeve; Cornelis J H van de Velde; GJ Liefers
Elderly postmenopausal patients with breast cancer are at increased risk for distant recurrence: a tamoxifen exemestane adjuvant multinational study analysis.
The oncologist 2013;18(1):8-13.
2013: Rosalinde K E Poortvliet; Rudi G J Westendorp; Willem J J Assendelft; Anton J M de Craen; Wouter de Ruijter; Jacobijn Gussekloo; Simon P Mooijaart; Jeanet W Blom
Blood pressure trends and mortality: the Leiden 85-plus Study.
Journal of hypertension 2013;31(1):63-70.
2013: Irmhild Altmann-Schneider; Andrea B Maier; P Eline Slagboom; Mark A Van Buchem; Jeroen van der Grond; Rudi G J Westendorp; Anton J M de Craen
Lower susceptibility to cerebral small vessel disease in human familial longevity: the Leiden Longevity Study.
Stroke; a journal of cerebral circulation 2013;44(1):9-14.
2013: Behnam Sabayan; Peter van Vliet; Anton J M de Craen; Wouter de Ruijter; Jacobijn Gussekloo; Rudi G J Westendorp
High blood pressure, physical and cognitive function, and risk of stroke in the oldest old: the Leiden 85-plus Study.
Stroke; a journal of cerebral circulation 2013;44(1):15-20.
2013: Yuliya Mysyuk; Rudi G J Westendorp; Jolanda Lindenberg
Added value of elder abuse definitions: a review.
Ageing research reviews 2013;12(1):50-7.
2012: Raymond Noordam; Pardis Pedram; P Eline Slagboom; Martinette T Streppel; Marian Beekman; Anton J M de Craen; Edith J Feskens; Andrea B Maier; Simon P Mooijaart; Johannes van Pelt; Rudi G J Westendorp; Diana van Heemst
Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2012;184(18):E963-8.
2012: Diana G Taekema; Rudi G J Westendorp; Anton J M de Craen; J Gussekloo; Andrea B Maier
Predicting survival in oldest old people.
The American journal of medicine 2012;125(12):1188-1194.e1.
2012: Irmhild Altmann-Schneider; Anton J M de Craen; Andrea B Maier; Pieternella E Slagboom; Mark A Van Buchem; Rudi G J Westendorp; Jeroen van der Grond
Brain tissue volumes in familial longevity: the Leiden Longevity Study.
Aging cell 2012;11(6):933-9.
2012: Mariette E C Waaijer; Rudi G J Westendorp; P Eline Slagboom; Michael van Ginkel; Diana van Heemst; Sharon D Catt; Anton J M de Craen; David A Gunn; Nicole M Hudson; Andrea B Maier
Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study.
Age (Dordrecht, Netherlands) 2012;34(6):1543-52.
2012: Behnam Sabayan; Mark A Van Buchem; Anton J M de Craen; Wouter de Ruijter; Jacobijn Gussekloo; Andrea B Maier; Anna M Oleksik; Rosalinde K E Poortvliet; Rudi G J Westendorp
High blood pressure and resilience to physical and cognitive decline in the oldest old: the Leiden 85-plus Study.
Journal of the American Geriatrics Society 2012;60(11):2014-9.
2012: Raymond Noordam; Maarten P Rozing; P Eline Slagboom; Cyrena C Tomlin; Diana van Heemst; Rudi G J Westendorp; Anton J M de Craen; David A Gunn; Andrea B Maier
Cortisol serum levels in familial longevity and perceived age: the Leiden longevity study.
Psychoneuroendocrinology 2012;37(10):1669-75.
2012: Carolina H Y Ling; P Eline Slagboom; Rudi G J Westendorp; Anton J M de Craen; Andrea B Maier
Handgrip strength at midlife and familial longevity : The Leiden Longevity Study.
Age (Dordrecht, Netherlands) 2012;34(5):1261-8.
2012: J Wouter Jukema; Christopher P Cannon; Anton J M de Craen; Rudi G J Westendorp; Stella Trompet
The controversies of statin therapy: weighing the evidence.
Journal of the American College of Cardiology 2012;60(10):875-81.
2012: Juliane Wolf; Christoph R Arnold; Andrea B Maier; Birgit Weinberger; Rudi G J Westendorp; Beatrix Grubeck-Loebenstein
The effect of chronological age on the inflammatory response of human fibroblasts.
Experimental gerontology 2012;47(9):749-53.
2012: Stella Trompet; Rudi G J Westendorp; Ian Ford; Wouter Jukema; Simon P Mooijaart; David J Stott; Anton J M de Craen
Genetic variation in galectin-3 gene associates with cognitive function at old age.
Neurobiology of aging 2012;33(9):2232.e1-2232.e9.
2012: Clara Kurniawan; Anton J M de Craen; Jan de Laat; Jacobijn Gussekloo; Rudi G J Westendorp; Eric van Exel
Gene dose of apolipoprotein E and age-related hearing loss.
Neurobiology of aging 2012;33(9):2230.e7-2230.e12.
2012: Baris Gencer; Jacobijn Gussekloo; Massimo Iacoviello; J Wouter Jukema; Kay-Tee Khaw; Robert N Luben; David Nanchen; Anne B Newman; Nicolas Rodondi; Vincenzo Triggiani; Vanessa Virgini; Eric Vittinghoff; Rudi G J Westendorp; Drahomir Aujesky; Philippe Balmer; Douglas C Bauer; Anne R Cappola; Tinh-Hai Collet; Jacques Cornuz; Wendy P J den Elzen
Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts.
Circulation 2012;126(9):1040-9.
2012: Karel G M Beenakker; Gillian Butler-Brown; Bouke J Duijnisveld; Rob G H H Nelissen; Henrica M J Van Der Linden; Cornelis P J Visser; Rudi G J Westendorp; Andrea B Maier
Muscle characteristics in patients with chronic systemic inflammation.
Muscle & nerve 2012;46(2):204-9.
2012: Mariëtte E C Waaijer; Rudi G J Westendorp; Anton J M de Craen; David A Gunn; William E Parish; John M Sedivy; Pieternella E Slagboom; Barbara H Strongitharm; Diana van Heemst; Andrea B Maier
The number of p16INK4a positive cells in human skin reflects biological age.
Aging cell 2012;11(4):722-5.
2012: Carolien A Wijsman; Simon P Mooijaart; Rudi G J Westendorp; Andrea B Maier
Responsiveness of the innate immune system and glucose concentrations in the oldest old.
Age (Dordrecht, Netherlands) 2012;34(4):983-6.
2012: Pim Dekker; Roeland W Dirks; David Gunn; Aart G Jochemsen; Fei-Ling Lim; Tony McBryan; Julia Nagel; Hans J Tanke; Diana van Heemst; Matty Verlaan-de Vries; Rudi G J Westendorp; Peter D Adams; Andrea B Maier
Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts.
Mechanisms of ageing and development 2012;133(7):498-507.
2012: Jorien M Willems; Anton J M de Craen; Rob G H H Nelissen; Peter A van Luijt; Rudi G J Westendorp; Gerard J Blauw
Haemoglobin predicts length of hospital stay after hip fracture surgery in older patients.
Maturitas 2012;72(3):225-8.
2012: Jorien M Willems; Anton J M de Craen; Wendy P J den Elzen; Jacobijn Gussekloo; L Tom Vlasveld; Rudi G J Westendorp; Gerard J Blauw
No increased mortality risk in older persons with unexplained anaemia.
Age and ageing 2012;41(4):501-6.
2012: Diana G Taekema; Rudi G J Westendorp; Carel G M Meskers; Gerard J Blauw; Ian D Cameron; Anton J M de Craen; Susan E Kurrle; Carolina H Y Ling; Andrea B Maier
Temporal relationship between handgrip strength and cognitive performance in oldest old people.
Age and ageing 2012;41(4):506-12.
2012: Tinh-Hai Collet; Jacques Cornuz; Wendy P J den Elzen; Jayne A Franklyn; Bariş Gencer; Jacobijn Gussekloo; Giorgio Iervasi; Kay-Tee Khaw; Robert N Luben; Rui M B Maciel; Patrick Maisonneuve; Sabrina Molinaro; Anne B Newman; Nicolas Rodondi; José A Sgarbi; Eric Vittinghoff; Henry Völzke; John P Walsh; Rudi G J Westendorp; Bjørn O Asvold; Philippe Balmer; Douglas Charles Bauer; Alexandra Bremner; Anne R Cappola
Subclinical hyperthyroidism and the risk of coronary heart disease and mortality.
Archives of internal medicine 2012;172(10):799-809.
2012: Mette Soerensen; Tinna Stevnsner; H Eka D Suchiman; Qihua Tan; Mikael Thinggaard; James W Vaupel; Rudi G J Westendorp; Marian Beekman; Vilhelm A Bohr; Kaare Christensen; Serena Dato; Anton J M de Craen; Rune Jacobsen; Rabea Kleindorp; Matt McGue; Almut Nebel; Stefan Schreiber; P Eline Slagboom; Lene Christiansen
Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.
Experimental gerontology 2012;47(5):379-87.
2012: Pim Dekker; Roeland W Dirks; P Eline Slagboom; Hans J Tanke; Laurens M van Baalen; Diana van Heemst; Rudi G J Westendorp; Andrea B Maier
Chronic inhibition of the respiratory chain in human fibroblast cultures: differential responses related to subject chronological and biological age.
The journals of gerontology. Series A, Biological sciences and medical sciences 2012;67(5):456-64.
2012: Behnam Sabayan; Mark A Van Buchem; Matthias J P van Osch; Peter van Vliet; Anton J M de Craen; Steffy Jansen; Anna M Oleksik; Rudi G J Westendorp
Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia: a meta-analysis of transcranial Doppler studies.
Ageing research reviews 2012;11(2):271-7.
2012: Maarten J Wensink; Maarten P Rozing; Diana van Heemst; Rudi G J Westendorp
The maintenance gap: a new theoretical perspective on the evolution of aging.
Biogerontology 2012;13(2):197-201.
2012: David Nanchen; Nicolas Rodondi; Naveed Sattar; David J Stott; Stella Trompet; Paul Welsh; Rudi G J Westendorp; Anton J M de Craen; Ian Ford; Jacobijn Gussekloo; J Wouter Jukema; Peter W Macfarlane; Simon P Mooijaart
Subclinical thyroid dysfunction and the risk of heart failure in older persons at high cardiovascular risk.
The Journal of clinical endocrinology and metabolism 2012;97(3):852-61.
2012: Pim Dekker; Roeland W Dirks; P Eline Slagboom; Axel Meissner; Hans J Tanke; Diana van Heemst; Rudi G J Westendorp; André M Deelder; Andrea B Maier
Human in vivo longevity is reflected in vitro by differential metabolism as measured by (1)H-NMR profiling of cell culture supernatants.
Molecular bioSystems 2012;8(3):783-9.
2012: Willemien van de Water; Rudi G J Westendorp; Esther Bastiaannet; Anton J M de Craen; Peyman Hadji; Annette Hasenburg; Elysée Hille; GJ Liefers; Christos Markopoulos; Johan W R Nortier; Hein Putter; Daniel Rea; Caroline Seynaeve; Cornelis J H van de Velde; Stephen E Jones
Association between age at diagnosis and disease-specific mortality among postmenopausal women with hormone receptor-positive breast cancer.
JAMA : the journal of the American Medical Association 2012;307(6):590-7.
2012: Hironobu Akao; Brendan M Buckley; Anton J M de Craen; Ian Ford; J Wouter Jukema; Kouji Kajinami; Christopher Packard; Eliana Polisecki; Michele Robertson; James Shepherd; Stella Trompet; Rudi G J Westendorp; Ernst J Schaefer
KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.
Atherosclerosis 2012;220(2):456-62.
2012: Hironobu Akao; Brendan M Buckley; Anton J M de Craen; Ian Ford; J Wouter Jukema; Kouji Kajinami; Christopher Packard; Eliana Polisecki; Michele Robertson; James Shepherd; Stella Trompet; Rudi G J Westendorp; Ernst J Schaefer
Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly.
Atherosclerosis 2012;220(2):413-7.
2012: Maarten P Rozing; Anton J M de Craen; Marijke Frölich; Andrea B Maier; Rudi G J Westendorp; Carolien A Wijsman; Diana van Heemst
Serum triiodothyronine levels and inflammatory cytokine production capacity.
Age (Dordrecht, Netherlands) 2012;34(1):195-201.
2012: Rosalinde K E Poortvliet; Naveed Sattar; Rudi G J Westendorp; Anton J M de Craen; Wouter de Ruijter; Ian Ford; Jacobijn Gussekloo; J Wouter Jukema; Suzanne M Lloyd; Simon P Mooijaart; Christopher J Packard; David J Stott
Blood pressure variability and cardiovascular risk in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER).
PloS one 2012;7(12):e52438.
2012: David Van Bodegom; Ulrika K Eriksson; Jeanine J Houwing-Duistermaat; Rudi G J Westendorp
Clustering of child mortality in a contemporary polygamous population in Africa.
Biodemography and social biology 2012;58(2):162-72.
2012: Frouke M Engelaer; David van Bodegom; Rudi G J Westendorp
Will lifestyle changes in later life improve survival?
BMJ (Clinical research ed.) 2012;345():e6897.
2012: Jacob J E Koopman; David van Bodegom; J Wouter Jukema; Rudi G J Westendorp
Risk of cardiovascular disease in a traditional African population with a high infectious load: a population-based study.
PloS one 2012;7(10):e46855.
2012: Dov Shiffman; P Eline Slagboom; David J Stott; Stella Trompet; Rudi G J Westendorp; Brendan M Buckley; Joseph J Catanese; Anton J M de Craen; James J Devlin; Ian Ford; Olga A Iakoubova; Todd G Kirchgessner; Judy Z Louie; Christopher J Packard; Charles M Rowland; Frank M Sacks; Naveed Sattar; J Wouter Jukema
Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.
PloS one 2012;7(5):e38240.
2012: Esther Bastiaannet; Anton J M de Craen; Maryska L G Janssen-Heijnen; Cornelis J H van de Velde; Willemien van de Water; Rudi G J Westendorp; GJ Liefers
No excess mortality in patients aged 50 years and older who received treatment for ductal carcinoma in situ of the breast.
International journal of surgical oncology 2012;2012():567506.
2012: Wiebe Chr Verra; Rudi G J Westendorp; Gerard Jan Blauw; Anton J M de Craen; Jacobijn Gussekloo; Coen C M M Jaspars; Andrea B Maier; Rob G H H Nelissen
Total joint replacement in the past does not relate to a deteriorated functional level and health status in the oldest old.
Journal of aging research 2012;2012():968389.
2012: Raymond Noordam; Nicole Y L Oei; Hanno Pijl; P Eline Slagboom; Jeroen van der Grond; Diana van Heemst; Rudi G J Westendorp; Abimbola A Akintola; Anton J M de Craen; Steffy W M Jansen; Andrea B Maier
Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study.
PloS one 2012;7(2):e31166.
2012: Frouke M Engelaer; David van Bodegom; Rudi G J Westendorp
Hypotension is more risky than hypertension in very old people.
BMJ (Clinical research ed.) 2012;344():e721.
2012: Willemijn M Passtoors; Ann Scarborough; Marian Beekman; Judith M Boer; Joris Deelen; Jelle J Goeman; David A Gunn; Jeanine J Houwing-Duistermaat; Rolf H A M Vossen; Rudi G J Westendorp; Andrew J White; Bas J Zwaan; Erik B van den Akker; Gert-Jan B van Ommen; Ruud van der Breggen; Anton J M de Craen; Diana van Heemst; P Eline Slagboom
Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R.
PloS one 2012;7(1):e27759.
2012: Willemien van de Water; Rudi G J Westendorp; Esther Bastiaannet; Anton J M de Craen; Elysée Hille; GJ Liefers; Elma M Meershoek-Klein Kranenbarg; Robert Paridaens; Hein Putter; Caroline M Seynaeve; Cornelis J H van de Velde
Age-specific nonpersistence of endocrine therapy in postmenopausal patients diagnosed with hormone receptor-positive breast cancer: a TEAM study analysis.
The oncologist 2012;17(1):55-63.
2012: Andrea B Maier; Diana van Heemst; Joke Blom; Ron Cohen; Rudi G J Westendorp
Marked heterogeneity in growth characteristics of myoblast clonal cultures and myoblast mixed cultures obtained from the same individual.
Gerontology 2012;58(2):150-5.
2011: M Lourdes Sampietro; P Eline Slagboom; Rudolf P Talens; Rene A Tio; Stella Trompet; Erik B van den Akker; Jeffrey J W Verschuren; Rudi G J Westendorp; Harm-Jan Westra; Aeilko H Zwinderman; Peter de Knijff; Robbert J de Winter; Joris Deelen; Pieter A F M Doevendans; Lude Franke; Santhi Ganesh; Bas Heijmans; Adnan Kastrati; Werner Koch; Elizabeth G Nabel; J Wouter Jukema
A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention.
Human molecular genetics 2011;20(23):4748-57.
2011: Evelyna Derhovanessian; K Hähnel; Andrea B Maier; Robert Beck; Anton J M de Craen; Eline P Slagboom; Rudi G J Westendorp; Graham Pawelec
Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans.
The Journal of general virology 2011;92(Pt 12):2746-56.
2011: Maarten P Rozing; Eline P Slagboom; Rudi G J Westendorp; Carolien A Wijsman; Andrzej Bartke; Marian Beekman; Andrea B Maier; Simon P Mooijaart; Diana van Heemst
C-reactive protein and glucose regulation in familial longevity.
Age (Dordrecht, Netherlands) 2011;33(4):623-30.
2011: Paul Welsh; Rudi G J Westendorp; Anton J M de Craen; Ian Ford; J Wouter Jukema; Iain B McInnes; Heather M Murray; Chris J Packard; Naveed Sattar; David J Stott; Stella Trompet
Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(10):2338-44.
2011: Carolina H Y Ling; Anton J M de Craen; Dave A Gunn; Pieternella E Slagboom; Marcel P M Stokkel; Rudi G J Westendorp; Andrea B Maier
Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population.
Clinical nutrition (Edinburgh, Scotland) 2011;30(5):610-5.
2011: Joris Deelen; David A Gunn; Bas Heijmans; Quinta Helmer; Jeanine J Houwing-Duistermaat; Dennis Kremer; Maris Kuningas; Nico Lakenberg; Willemijn M Passtoors; Markus Perola; Fernando Rivadeneira; H Eka D Suchiman; Henning Tiemeier; Hae-Won Uh; André G Uitterlinden; Erik B van den Akker; Ruud van der Breggen; Frans van der Ouderaa; Cornelia M van Duijn; Diana van Heemst; Rudi G J Westendorp; Marian Beekman; Dorret I Boomsma; Kaare Christensen; Lene Christiansen; Anton J de Craen; Eco J de Geus; P Eline Slagboom
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Aging cell 2011;10(4):686-98.
2011: Wendy P J Den Elzen; Thomas B L Kirkwood; Carmen Martin-Ruiz; Thomas von Zglinicki; Rudi G J Westendorp; Jacobijn Gussekloo
Telomere length and anaemia in old age: results from the Newcastle 85-plus Study and the Leiden 85-plus Study.
Age and ageing 2011;40(4):494-500.
2011: Wendy P J den Elzen; Aloys C M Kroes; A C T M Vossen; Rudi G J Westendorp; Herman J M Cools; Jacobijn Gussekloo
Cytomegalovirus infection and responsiveness to influenza vaccination in elderly residents of long-term care facilities.
Vaccine 2011;29(29-30):4869-74.
2011: Anika A M Vaarhorst; Diana van Heemst; Rudi G J Westendorp; Marian Beekman; Bas Heijmans; Jeanine J Houwing-Duistermaat; P Eline Slagboom; Eka H D Suchiman
Lipid metabolism in long-lived families: the Leiden Longevity Study.
Age (Dordrecht, Netherlands) 2011;33(2):219-27.
2011: Peter W Macfarlane; Heather Murray; Naveed Sattar; David J Stott; Ian Ford; Brendan Buckley; J Wouter Jukema; Rudi G J Westendorp; James Shepherd
The incidence and risk factors for new onset atrial fibrillation in the PROSPER study.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2011;13(5):634-9.
2011: L Renee Ruhaak; Hae-Won Uh; Marian Beekman; Cornelis H Hokke; Rudi G J Westendorp; Jeanine Houwing-Duistermaat; Manfred Wuhrer; André M Deelder; P Eline Slagboom
Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health.
Journal of proteome research 2011;10(4):1667-74.
2011: Carolien A Wijsman; Andrea B Maier; Anton J M de Craen; Anita van den Biggelaar; Rudi G J Westendorp
An unopposed proinflammatory response is beneficial for survival in the oldest old. Results of the Leiden 85-plus Study.
The journals of gerontology. Series A, Biological sciences and medical sciences 2011;66(4):393-9.
2011: Frans L Opdam; Ania M Oleksik; Rudi G J Westendorp
Cholinesterase inhibitor treatment in patients with delirium.
Lancet 2011;377(9769):900-1; author reply 901.
2011: Irmhild Altmann-Schneider; Stella Trompet; Anton J M de Craen; Adriaan C G M van Es; J Wouter Jukema; David J Stott; Naveed Sattar; Rudi G J Westendorp; Mark A Van Buchem; Jeroen van der Grond
Cerebral microbleeds are predictive of mortality in the elderly.
Stroke; a journal of cerebral circulation 2011;42(3):638-44.
2011: Stella Trompet; Anton J M de Craen; J Wouter Jukema; Douwe Pons; P Eline Slagboom; D Kremer; E L E M Bollen; Rudi G J Westendorp
Variation in the CBP gene involved in epigenetic control associates with cognitive function.
Neurobiology of aging 2011;32(3):549.e1-8.
2011: Diana G Taekema; Carolina H Y Ling; Gerard Jan Blauw; Carel G Meskers; Rudi G J Westendorp; Anton J M de Craen; Andrea B Maier
Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women.
European journal of endocrinology / European Federation of Endocrine Societies 2011;164(2):189-96.
2011: Carolien A Wijsman; Maarten P Rozing; Trea C M Streefland; Saskia Le Cessie; Simon P Mooijaart; P Eline Slagboom; Rudi G J Westendorp; Hanno Pijl; Diana van Heemst
Familial longevity is marked by enhanced insulin sensitivity.
Aging cell 2011;10(1):114-21.
2011: Simon P Mooijaart; Eliana Polisecki; Naveed Sattar; Ernst J Schaefer; David J Stott; Stella Trompet; Thomas van Himbergen; Paul Welsh; Rudi G J Westendorp; Anton J M de Craen; Ian Ford; Sabine E Jahn
C-reactive protein and genetic variants and cognitive decline in old age: the PROSPER study.
PloS one 2011;6(9):e23890.
2011: Stella Trompet; Jeffrey J W Verschuren; Rudi G J Westendorp; Aeilko H Zwinderman; Anton J M de Craen; Robbert J De Winter; Pieter A F M Doevendans; M Arfan Ikram; Sandip M Kanse; Douwe Pons; P Eline Slagboom; René A Tio; J Wouter Jukema
Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality.
Stroke research and treatment 2011;2011():424759.
2011: Karin van der Hiele; Robert H A M Reijntjes; Alla A Vein; Rudi G J Westendorp; Mark A Van Buchem; E L E M Bollen; H A M Middelkoop; J Gert van Dijk
Electromyographic activity in the EEG in Alzheimer's disease: noise or signal?
International journal of Alzheimer's disease 2011;2011():547024.
2011: Carolien A Wijsman; Diana van Heemst; Maarten P Rozing; P Eline Slagboom; Marian Beekman; Anton J M de Craen; Andrea B Maier; Rudi G J Westendorp; Henk J Blom; Simon P Mooijaart
Homocysteine and familial longevity: the Leiden Longevity Study.
PloS one 2011;6(3):e17543.
2011: Esther Bastiaannet; Johanneke E A Portielje; Cornelis J H van de Velde; Anton J M de Craen; Susanne van der Velde; Peter Kuppen; Lydia G M van der Geest; M L G Janssen-Heijnen; Olaf M Dekkers; Rudi G J Westendorp; GJ Liefers
Lack of survival gain for elderly women with breast cancer.
The oncologist 2011;16(4):415-23.
2011: Simon P Mooijaart; Diana van Heemst; Raymond Noordam; Maarten P Rozing; Carolien A Wijsman; Anton J M de Craen; Rudi G J Westendorp; Marian Beekman; P Eline Slagboom
Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study.
Aging 2011;3(1):55-62.
2011: Douwe Pons; Stella Trompet; Anton J M de Craen; Peter E Thijssen; Paul H A Quax; Margreet R De Vries; Rutger J Wierda; Peter J van den Elsen; Pascalle S Monraats; Mark M Ewing; Bas Heijmans; P Eline Slagboom; Aeilko H Zwinderman; Pieter A Doevendans; René A Tio; Robbert J De Winter; Moniek P M de Maat; Olga A Iakoubova; Naveed Sattar; Jim Shepherd; Rudi G J Westendorp; J Wouter Jukema
Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies.
Heart (British Cardiac Society) 2011;97(2):143-50.
2011: Pim Dekker; Mark J de Lange; Roeland W Dirks; Diana van Heemst; Hans J Tanke; Rudi G J Westendorp; Andrea B Maier
Relation between maximum replicative capacity and oxidative stress-induced responses in human skin fibroblasts in vitro.
The journals of gerontology. Series A, Biological sciences and medical sciences 2011;66(1):45-50.
2011: Laura W de Jong; Luca Ferrarini; Jeroen van der Grond; Julien Milles; Johan H C Reiber; Rudi G J Westendorp; Edward L E M Bollen; Huub A M Middelkoop; Mark A Van Buchem
Shape abnormalities of the striatum in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2011;23(1):49-59.
2011: Diana G Taekema; Andrea B Maier; Rudi G J Westendorp; Anton J M de Craen
Higher blood pressure is associated with higher handgrip strength in the oldest old.
American journal of hypertension 2011;24(1):83-9.
2010: Wendy P J den Elzen; Jorien M Willems; Rudi G J Westendorp; Anton J M de Craen; Gerard Jan Blauw; Luigi Ferrucci; Willem J J Assendelft; Jacobijn Gussekloo
Effect of erythropoietin levels on mortality in old age: the Leiden 85-plus Study.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2010;182(18):1953-8.
2010: Marian Beekman; Christa Nederstigt; H Eka D Suchiman; Dennis Kremer; Ruud van der Breggen; Nico Lakenberg; Wendimagegn Ghidey Alemayehu; Anton J M de Craen; Rudi G J Westendorp; Dorret I Boomsma; Eco J C De Geus; Jeanine J Houwing-Duistermaat; Bastiaan T Heijmans; P Eline Slagboom
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(42):18046-9.
2010: Evelyna Derhovanessian; Andrea B Maier; Robert Beck; Gerhard Jahn; K Hähnel; P Eline Slagboom; Anton J M de Craen; Rudi G J Westendorp; Graham Pawelec
Hallmark features of immunosenescence are absent in familial longevity.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(8):4618-24.
2010: Karel G M Beenakker; Carolina H Ling; Carel G M Meskers; Anton J M de Craen; Theo Stijnen; Rudi G J Westendorp; Andrea B Maier
Patterns of muscle strength loss with age in the general population and patients with a chronic inflammatory state.
Ageing research reviews 2010;9(4):431-6.
2010: Nicolas Rodondi; Wendy P J den Elzen; Douglas Charles Bauer; Anne R Cappola; Salman Razvi; John P Walsh; Bjørn O Asvold; Giorgio Iervasi; Misa Imaizumi; Tinh-Hai Collet; Alexandra Bremner; Patrick Maisonneuve; José A Sgarbi; Kay-Tee Khaw; Mark P J Vanderpump; Anne B Newman; Jacques Cornuz; Jayne A Franklyn; Rudi G J Westendorp; Eric Vittinghoff; Jacobijn Gussekloo
Subclinical hypothyroidism and the risk of coronary heart disease and mortality.
JAMA : the journal of the American Medical Association 2010;304(12):1365-74.
2010: Peter van Vliet; Rudi G J Westendorp; Diana van Heemst; Anton J M de Craen; Anna M Oleksik
Cognitive decline precedes late-life longitudinal changes in vascular risk factors.
Journal of neurology, neurosurgery, and psychiatry 2010;81(9):1028-32.
2010: Wendy P J den Elzen; Jacobijn Gussekloo; Jorien M Willems; Anton J M de Craen; Gerard J Blauw; Gerard J Blauw; W J J Assendelft; Rudi G J Westendorp
Predictive value of low ferritin in older persons with anemia with and without inflammation: the Leiden 85-plus Study.
Journal of the American Geriatrics Society 2010;58(8):1601-3.
2010: Sjoerd M Euser; Naveed Sattar; Jacqueline C M Witteman; Eduard L E M Bollen; Eric J G Sijbrands; Albert Hofman; Ivan J Perry; Monique Breteler; Rudi G J Westendorp
A prospective analysis of elevated fasting glucose levels and cognitive function in older people: results from PROSPER and the Rotterdam Study.
Diabetes 2010;59(7):1601-7.
2010: Jorien M Willems; Stella Trompet; Gerard J Blauw; Rudi G J Westendorp; Anton J M de Craen
White blood cell count and C-reactive protein are independent predictors of mortality in the oldest old.
The journals of gerontology. Series A, Biological sciences and medical sciences 2010;65(7):764-8.
2010: D Willemijn Maas; Rudi G J Westendorp; Jorien M Willems; Anton J M de Craen; Rose C van der Mast
TNF-α antagonist infliximab in the treatment of depression in older adults: results of a prematurely ended, randomized, placebo-controlled trial.
Journal of clinical psychopharmacology 2010;30(3):343-5.
2010: Diana G Taekema; Jacobijn Gussekloo; Andrea B Maier; Rudi G J Westendorp; Anton J M de Craen
Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old.
Age and ageing 2010;39(3):331-7.
2010: Peter van Vliet; Anna M Oleksik; Diana van Heemst; Anton J M de Craen; Rudi G J Westendorp
Dynamics of traditional metabolic risk factors associate with specific causes of death in old age.
The journals of gerontology. Series A, Biological sciences and medical sciences 2010;65(5):488-94.
2010: Eliana Polisecki; Inga Peter; Jason S Simon; Robert A Hegele; Michele Robertson; Ian Ford; James Shepherd; Christopher Packard; J Wouter Jukema; Anton J M de Craen; Rudi G J Westendorp; Brendan M Buckley; Ernst J Schaefer
Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly.
Journal of lipid research 2010;51(5):1201-7.
2010: Maarten P Rozing; Rudi G J Westendorp; Anton J M de Craen; Marijke Frölich; Bas Heijmans; Marian Beekman; Carolien Wijsman; Simon P Mooijaart; Gerard J Blauw; P Eline Slagboom; Diana van Heemst
Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study.
The journals of gerontology. Series A, Biological sciences and medical sciences 2010;65(4):365-8.
2010: Carolina H Y Ling; Diana Taekema; Anton J M de Craen; Jacobijn Gussekloo; Rudi G J Westendorp; Andrea B Maier
Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2010;182(5):429-35.
2010: Maarten P Rozing; Rudi G J Westendorp; Anton J M de Craen; Marijke Frölich; Moniek C M de Goeij; Bas Heijmans; Marian Beekman; Carolien A Wijsman; Simon P Mooijaart; Gerard J Blauw; P Eline Slagboom; Diana van Heemst
Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study.
Journal of the American Geriatrics Society 2010;58(3):564-9.
2010: David J Stott; Michele Robertson; Ann Rumley; Paul Welsh; Naveed Sattar; Christopher J Packard; James Shepherd; Stella Trompet; Rudi G J Westendorp; Anton J M de Craen; J Wouter Jukema; Brendan Buckley; Ian Ford; Gordon D O Lowe
Activation of hemostasis and decline in cognitive function in older people.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(3):605-11.
2010: Maris Kuningas; David van Bodegom; Linda May; Johannes J Meij; P Eline Slagboom; Rudi G J Westendorp
Common CFTR gene variants influence body composition and survival in rural Ghana.
Human genetics 2010;127(2):201-6.
2010: Linda May; Maris Kuningas; David van Bodegom; Hans J Meij; Marijke Frolich; P Eline Slagboom; Alberto Mantovani; Rudi G J Westendorp
Genetic variation in pentraxin (PTX) 3 gene associates with PTX3 production and fertility in women.
Biology of reproduction 2010;82(2):299-304.
2010: L Renee Ruhaak; Hae-Won Uh; Marian Beekman; Carolien A M Koeleman; Cornelis H Hokke; Rudi G J Westendorp; Manfred Wuhrer; Jeanine J Houwing-Duistermaat; P Eline Slagboom; André M Deelder
Decreased levels of bisecting GlcNAc glycoforms of IgG are associated with human longevity.
PloS one 2010;5(9):e12566.
2010: Adriaan C G M van Es; Jeroen van der Grond; V Hester ten Dam; Anton J M de Craen; Gerard J Blauw; Rudi G J Westendorp; Faiza Admiraal-Behloul; Mark A Van Buchem
Associations between total cerebral blood flow and age related changes of the brain.
PloS one 2010;5(3):e9825.
2010: Paul Welsh; Eliana Polisecki; Michele Robertson; Sabine Jahn; Brendan M Buckley; Anton J M de Craen; Ian Ford; J Wouter Jukema; Peter W Macfarlane; Chris J Packard; David J Stott; Rudi G J Westendorp; James Shepherd; Aroon D Hingorani; George Davey Smith; Ernst Schaefer; Naveed Sattar
Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach.
The Journal of clinical endocrinology and metabolism 2010;95(1):93-9.
2010: Stella Trompet; Peter van Vliet; Anton J M de Craen; Jelle Jolles; Brendan M Buckley; Michael B Murphy; Ian Ford; Peter W Macfarlane; Naveed Sattar; Chris J Packard; David J Stott; Jim Shepherd; E L E M Bollen; Gerard J Blauw; J Wouter Jukema; Rudi G J Westendorp
Pravastatin and cognitive function in the elderly. Results of the PROSPER study.
Journal of neurology 2010;257(1):85-90.
2009: Stella Trompet; J Wouter Jukema; Martijn B Katan; Gerard J Blauw; Naveed Sattar; Brendan Buckley; Muriel Caslake; Ian Ford; Jim Shepherd; Rudi G J Westendorp; Anton J M de Craen
Apolipoprotein e genotype, plasma cholesterol, and cancer: a Mendelian randomization study.
American journal of epidemiology 2009;170(11):1415-21.
2009: Eric van Exel; Piet Eikelenboom; Hannie C Comijs; Marijke Frölich; Johannes H Smit; Max L Stek; Philip scheltens; Jan E Eefsting; Rudi G J Westendorp
Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease.
Archives of general psychiatry 2009;66(11):1263-70.
2009: Gerard Noppe; Pim Dekker; Corine de Koning-Treurniet; Joke Blom; Diana van Heemst; Roeland W Dirks; Hans J Tanke; Rudi G J Westendorp; Andrea B Maier
Rapid flow cytometric method for measuring senescence associated beta-galactosidase activity in human fibroblasts.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(11):910-6.
2009: Rudi G J Westendorp; Diana van Heemst; Maarten P Rozing; Marijke Frölich; Simon P Mooijaart; Gerard J Blauw; Marian Beekman; Bas Heijmans; Anton J M de Craen; P Eline Slagboom
Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.
Journal of the American Geriatrics Society 2009;57(9):1634-7.
2009: Pim Dekker; Andrea B Maier; Diana van Heemst; Corine de Koning-Treurniet; Johanna Blom; Roeland W Dirks; Hans J Tanke; Rudi G J Westendorp
Stress-induced responses of human skin fibroblasts in vitro reflect human longevity.
Aging cell 2009;8(5):595-603.
2009: Wendy P J den Elzen; Jorien M Willems; Rudi G J Westendorp; Anton J M de Craen; Willem J J Assendelft; Jacobijn Gussekloo
Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2009;181(3-4):151-7.
2009: Maarten P Rozing; Rudi G J Westendorp; Marijke Frölich; Anton J M de Craen; Marian Beekman; Bas Heijmans; Simon P Mooijaart; Gerard J Blauw; P Eline Slagboom; Diana van Heemst
Human insulin/IGF-1 and familial longevity at middle age.
Aging 2009;1(8):714-22.
2009: David van Bodegom; Linda May; Maris Kuningas; Ralf Kaptijn; Fleur Thomése; Hans J Meij; J Amankwa; Rudi G J Westendorp
Socio-economic status by rapid appraisal is highly correlated with mortality risks in rural Africa.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2009;103(8):795-800.
2009: Andrea B Maier; Rudi G J Westendorp
Relation between replicative senescence of human fibroblasts and life history characteristics.
Ageing research reviews 2009;8(3):237-43.
2009: Sjoerd M Euser; Thomas van Bemmel; Miranda T Schram; Jacobijn Gussekloo; Albert Hofman; Rudi G J Westendorp; Monique Breteler
The effect of age on the association between blood pressure and cognitive function later in life.
Journal of the American Geriatrics Society 2009;57(7):1232-7.
2009: Naveed Sattar; Heather M Murray; Paul Welsh; Gerard J Blauw; Brendan M Buckley; Stuart Cobbe; Anton J M de Craen; GD Lowe; J Wouter Jukema; Peter W Macfarlane; Michael B. Murphy; David J Stott; Rudi G J Westendorp; James Shepherd; Ian Ford; Chris J Packard
Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events?
PLoS medicine 2009;6(6):e1000099.
2009: Bert Vaes; Wouter de Ruijter; Jan Degryse; Rudi G J Westendorp; Jacobijn Gussekloo
Clinical relevance of a raised plasma N-terminal pro-brain natriuretic peptide level in a population-based cohort of nonagenarians.
Journal of the American Geriatrics Society 2009;57(5):823-9.
2009: Peter van Vliet; Roos C van der Mast; Marianne van den Broek; Rudi G J Westendorp; Anton J M de Craen
Use of benzodiazepines, depressive symptoms and cognitive function in old age.
International journal of geriatric psychiatry 2009;24(5):500-8.
2009: Jacqueline M Vink; August B Smit; Eco J C De Geus; Patrick F Sullivan; Gonneke Willemsen; Jouke-Jan Hottenga; Johannes H Smit; Witte J G Hoogendijk; Frans G Zitman; Leena Peltonen; Jaakko Kaprio; Nancy L Pedersen; Patrik K E Magnusson; Tim D Spector; Kirsten Ohm Kyvik; Katherine I Morley; Andrew C Heath; Nicholas G Martin; Rudi G J Westendorp; P Eline Slagboom; Henning Tiemeier; Albert Hofman; André G Uitterlinden; Yurii S Aulchenko; Najaf Amin; C.M. Duijn; Brenda W Penninx; Dorret I Boomsma
Genome-wide association study of smoking initiation and current smoking.
American journal of human genetics 2009;84(3):367-79.
2009: Kristel C M C Koeijvoets; Simon P Mooijaart; Geesje M Dallinga-Thie; Joep C Defesche; Ewout W Steyerberg; Rudi G J Westendorp; John J P Kastelein; P Martin van Hagen; Eric J G Sijbrands
Complement factor H Y402H decreases cardiovascular disease risk in patients with familial hypercholesterolaemia.
European heart journal 2009;30(5):618-23.
2009: Maris Kuningas; Simon P Mooijaart; Jelle Jolles; P Eline Slagboom; Rudi G J Westendorp; Diana van Heemst
VDR gene variants associate with cognitive function and depressive symptoms in old age.
Neurobiology of aging 2009;30(3):466-73.
2009: Paul Welsh; Heather M Murray; Brendan M Buckley; Anton J M de Craen; Ian Ford; J Wouter Jukema; Peter W Macfarlane; Chris J Packard; David J Stott; Rudi G J Westendorp; James Shepherd; Naveed Sattar
Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population.
Diabetes care 2009;32(2):308-10.
2009: David J Stott; Paul Welsh; Ann Rumley; Michele Robertson; Ian Ford; Naveed Sattar; Rudi G J Westendorp; J Wouter Jukema; Stuart M Cobbe; Gordon D O Lowe
Adipocytokines and risk of stroke in older people: a nested case-control study.
International journal of epidemiology 2009;38(1):253-61.
2009: Ian Ford; Vladimir Bezlyak; David J Stott; Naveed Sattar; Chris J Packard; Ivan Perry; Brendan M Buckley; J Wouter Jukema; Anton J M de Craen; Rudi G J Westendorp; James Shepherd
Reduced glomerular filtration rate and its association with clinical outcome in older patients at risk of vascular events: secondary analysis.
PLoS medicine 2009;6(1):e16.
2009: Jeanine J Houwing-Duistermaat; A Callegaro; Marian Beekman; Rudi G J Westendorp; P Eline Slagboom; Johannes C van Houwelingen
Weighted statistics for aggregation and linkage analysis of human longevity in selected families: the Leiden Longevity Study.
Statistics in medicine 2009;28(1):140-51.
2009: Maris Kuningas; Linda May; Riin Tamm; David van Bodegom; Anita van den Biggelaar; Johannes J Meij; Marijke Frölich; Juventus Ziem; Helena E D Suchiman; Andres Metspalu; P Eline Slagboom; Rudi G J Westendorp
Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population.
PloS one 2009;4(11):e7795.
2009: Wouter de Ruijter; Rudi G J Westendorp; Willem J J Assendelft; Wendy P J den Elzen; Anton J M de Craen; Saskia Le Cessie; Jacobijn Gussekloo
Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study.
BMJ (Clinical research ed.) 2009;338():a3083.
2008: Maarten P Rozing; Rudi G J Westendorp
Parallel lines: nothing has changed?
Aging cell 2008;7(6):924-7.
2008: Stella Trompet; J Wouter Jukema; Ian Ford; James Shepherd; Jacobijn Gussekloo; Brendan M Buckley; Rudi G J Westendorp; Anton J M de Craen
Statins and blood pressure.
Archives of internal medicine 2008;168(21):2383.
2008: Wendy P J den Elzen; Rudi G J Westendorp; Marijke Frölich; Wouter de Ruijter; Willem J J Assendelft; Jacobijn Gussekloo
Vitamin B12 and folate and the risk of anemia in old age: the Leiden 85-Plus Study.
Archives of internal medicine 2008;168(20):2238-44.
2008: Jorien M Willems; Stella Trompet; P Eline Slagboom; Anton J M de Craen; Rudi G J Westendorp
Hematopoietic capacity and exceptional survival: the Leiden Longevity Study.
Journal of the American Geriatrics Society 2008;56(11):2009-13.
2008: Rebecca C Painter; Rudi G J Westendorp; Susanne de Rooij; Clive Osmond; David J P Barker; Tessa J Roseboom
Increased reproductive success of women after prenatal undernutrition.
Human reproduction (Oxford, England) 2008;23(11):2591-5.
2008: Sjoerd M Euser; Diana van Heemst; Peter van Vliet; Monique Breteler; Rudi G J Westendorp
Insulin/Insulin-like growth factor-1 signaling and cognitive function in humans.
The journals of gerontology. Series A, Biological sciences and medical sciences 2008;63(9):907-10.
2008: Eliana Polisecki; Inga Peter; Michele Robertson; Alex D McMahon; Ian Ford; Christopher Packard; James Shepherd; J Wouter Jukema; Gerard J Blauw; Rudi G J Westendorp; Anton J M de Craen; Stella Trompet; Brendan M Buckley; Michael B. Murphy; Jose Ordovas; Ernst Schaefer
Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population.
Atherosclerosis 2008;200(1):95-101.
2008: Eliana Polisecki; Hind Muallem; Nobuyo Maeda; Inga Peter; Michele Robertson; Alex D McMahon; Ian Ford; Christopher Packard; James Shepherd; J Wouter Jukema; Rudi G J Westendorp; Anton J M de Craen; Brendan M Buckley; Jose Ordovas; Ernst Schaefer
Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER.
Atherosclerosis 2008;200(1):109-14.
2008: S Trompet; Anton J M de Craen; P Eline Slagboom; James Shepherd; Gerard J Blauw; Michael B. Murphy; E L E M Bollen; Brendan M Buckley; Ian Ford; Allan Gaw; Peter W Macfarlane; Chris J Packard; David J Stott; Rudi G J Westendorp; J Wouter Jukema
Lymphotoxin-alpha C804A polymorphism is a risk factor for stroke. The PROSPER study.
Experimental gerontology 2008;43(8):801-5.
2008: Andrea B Maier; Ilko L Maier; Diana van Heemst; Rudi G J Westendorp
Colony formation and colony size do not reflect the onset of replicative senescence in human fibroblasts.
The journals of gerontology. Series A, Biological sciences and medical sciences 2008;63(7):655-9.
2008: Naveed Sattar; Alex McConnachie; A Gerald Shaper; Gerard J Blauw; Brendan M Buckley; Anton J M de Craen; Ian Ford; Nita G Forouhi; Dilys J Freeman; J Wouter Jukema; Lucy Lennon; Peter W Macfarlane; Michael B. Murphy; Chris J Packard; David J Stott; Rudi G J Westendorp; Peter H Whincup; James Shepherd; S Goya Wannamethee
Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies.
Lancet 2008;371(9628):1927-35.
2008: Sjoerd M Euser; Miranda T Schram; Albert Hofman; Rudi G J Westendorp; Monique Breteler
Measuring cognitive function with age: the influence of selection by health and survival.
Epidemiology (Cambridge, Mass.) 2008;19(3):440-7.
2008: Karin van der Hiele; Eduard L E M Bollen; Alla A Vein; Robert H A M Reijntjes; Rudi G J Westendorp; Mark A Van Buchem; Huub A M Middelkoop; J Gert van Dijk
EEG markers of future cognitive performance in the elderly.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2008;25(2):83-9.
2008: S Trompet; Anton J M de Craen; P Slagboom; J Shepherd; G J Blauw; Michael B. Murphy; E L E M Bollen; B M Buckley; I Ford; A Gaw; P W Macfarlane; C J Packard; D J Stott; J W Jukema; Rudi G J Westendorp
Genetic variation in the interleukin-1 beta-converting enzyme associates with cognitive function. The PROSPER study.
Brain : a journal of neurology 2008;131(Pt 4):1069-77.
2008: P Martijn den Reijer; Andrea B Maier; Rudi G J Westendorp; Diana van Heemst
Influence of the TP53 codon 72 polymorphism on the cellular responses to X-irradiation in fibroblasts from nonagenarians.
Mechanisms of ageing and development 2008;129(4):175-82.
2008: Maris Kuningas; Simon P Mooijaart; Diana van Heemst; Bas J Zwaan; P Eline Slagboom; Rudi G J Westendorp
Genes encoding longevity: from model organisms to humans.
Aging cell 2008;7(2):270-80.
2008: Roos C van der Mast; David J Vinkers; Max L Stek; M C Bek; Rudi G J Westendorp; Jacobijn Gussekloo; Anton J M de Craen
Vascular disease and apathy in old age. The Leiden 85-Plus Study.
International journal of geriatric psychiatry 2008;23(3):266-71.
2008: Luca Ferrarini; Walter M Palm; Hans Olofsen; Roald van der Landen; Gerard Jan Blauw; Rudi G J Westendorp; E L E M Bollen; H A M Middelkoop; Johan H C Reiber; Mark A Van Buchem; Faiza Admiraal-Behloul
MMSE scores correlate with local ventricular enlargement in the spectrum from cognitively normal to Alzheimer disease.
NeuroImage 2008;39(4):1832-8.
2008: Jimmy F P Berbée; Simon P Mooijaart; Anton J M de Craen; Louis M Havekes; Diana van Heemst; Patrick C N Rensen; Rudi G J Westendorp
Plasma apolipoprotein CI protects against mortality from infection in old age.
The journals of gerontology. Series A, Biological sciences and medical sciences 2008;63(2):122-6.
2008: Stella Trompet; Rudi G J Westendorp; Adriaan M Kamper; Anton J M de Craen
Use of calcium antagonists and cognitive decline in old age. The Leiden 85-plus study.
Neurobiology of aging 2008;29(2):306-8.
2008: Wouter De Ruijter; Willem J J Assendelft; Peter W Macfarlane; Rudi G J Westendorp; Jacobijn Gussekloo
The additional value of routine electrocardiograms in cardiovascular risk management of older people.
Scandinavian journal of primary health care 2008;26(3):147-53.
2008: Andrea B Maier; Diana van Heemst; Rudi G J Westendorp
Relation between body height and replicative capacity of human fibroblasts in nonagenarians.
The journals of gerontology. Series A, Biological sciences and medical sciences 2008;63(1):43-5.
2007: Miranda T Schram; Stella Trompet; Adriaan M Kamper; Anton J M de Craen; Albert Hofman; Sjoerd M Euser; Monique Breteler; Rudi G J Westendorp
Serum calcium and cognitive function in old age.
Journal of the American Geriatrics Society 2007;55(11):1786-92.
2007: Chris J Packard; Rudi G J Westendorp; David J Stott; Muriel J Caslake; Heather M Murray; James Shepherd; Gerard J Blauw; Michael B. Murphy; E L E M Bollen; Brendan M Buckley; Stuart M Cobbe; Ian Ford; Allan Gaw; Michael Hyland; J Wouter Jukema; Adriaan M Kamper; Peter W Macfarlane; Jelle Jolles; Ivan J Perry; Brian J Sweeney; Cillian Twomey
Association between apolipoprotein E4 and cognitive decline in elderly adults.
Journal of the American Geriatrics Society 2007;55(11):1777-85.
2007: A C G M van Es; Wiesje M van der Flier; Faiza Admiraal-Behloul; Hans Olofsen; E L E M Bollen; H A M Middelkoop; Annelies W E Weverling-Rijnsburger; Jeroen van der Grond; Rudi G J Westendorp; Mark A Van Buchem
Lobar distribution of changes in gray matter and white matter in memory clinic patients: detected using magnetization transfer imaging.
AJNR. American journal of neuroradiology 2007;28(10):1938-42.
2007: Simon P Mooijaart; Kristel M C Koeijvoets; Eric J G Sijbrands; Mohamed R Daha; Rudi G J Westendorp
Complement Factor H polymorphism Y402H associates with inflammation, visual acuity, and cardiovascular mortality in the elderly population at large.
Experimental gerontology 2007;42(11):1116-22.
2007: Diana van Heemst; P M den Reijer; Rudi G J Westendorp
Ageing or cancer: a review on the role of caretakers and gatekeepers.
European journal of cancer (Oxford, England : 1990) 2007;43(15):2144-52.
2007: G J Izaks; Rudi G J Westendorp
[Comments on screening spirometry for detection of COPD].
Nederlands tijdschrift voor geneeskunde 2007;151(37):2073-4; author reply 2074.
2007: Rudi G J Westendorp
[Reforming the healthcare for older patients with co-morbidity].
Nederlands tijdschrift voor geneeskunde 2007;151(36):1973-4.
2007: E van den Berg; Geert Jan Biessels; Anton J M de Craen; J Gussekloo; Rudi G J Westendorp
The metabolic syndrome is associated with decelerated cognitive decline in the oldest old.
Neurology 2007;69(10):979-85.
2007: Maris Kuningas; Mariëlle Putters; Rudi G J Westendorp; P Eline Slagboom; Diana van Heemst
SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study.
The journals of gerontology. Series A, Biological sciences and medical sciences 2007;62(9):960-5.
2007: Diana G Taekema; Rudi G J Westendorp; Marijke Frölich; Jacobijn Gussekloo
High innate production capacity of tumor necrosis factor-alpha and decline of handgrip strength in old age.
Mechanisms of ageing and development 2007;128(9):517-21.
2007: Karin van der Hiele; Alla A Vein; Robert H A M Reijntjes; Rudi G J Westendorp; E L E M Bollen; Mark A Van Buchem; J Gert van Dijk; H A M Middelkoop
EEG correlates in the spectrum of cognitive decline.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2007;118(9):1931-9.
2007: Karin van der Hiele; Alla A Vein; A van der Welle; J van der Grond; Rudi G J Westendorp; E L E M Bollen; Mark A Van Buchem; J Gert van Dijk; H A M Middelkoop
EEG and MRI correlates of mild cognitive impairment and Alzheimer's disease.
Neurobiology of aging 2007;28(9):1322-9.
2007: Anita van den Biggelaar; Jacobijn Gussekloo; Anton J M de Craen; Marijke Frölich; Max L Stek; Roos C van der Mast; Rudi G J Westendorp
Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age.
Experimental gerontology 2007;42(7):693-701.
2007: Wouter de Ruijter; Rudi G J Westendorp; Peter W Macfarlane; J Wouter Jukema; W J J Assendelft; Jacobijn Gussekloo
The routine electrocardiogram for cardiovascular risk stratification in old age: the Leiden 85-plus study.
Journal of the American Geriatrics Society 2007;55(6):872-7.
2007: Maris Kuningas; Roel de Rijk; Rudi G J Westendorp; Jelle Jolles; P Eline Slagboom; Diana van Heemst
Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(6):1295-301.
2007: Miranda T Schram; Sjoerd M Euser; Anton J M de Craen; Jacqueline C M Witteman; Marijke Frölich; Albert Hofman; Jelle Jolles; Monique Breteler; Rudi G J Westendorp
Systemic markers of inflammation and cognitive decline in old age.
Journal of the American Geriatrics Society 2007;55(5):708-16.
2007: Andrea B Maier; Rudi G J Westendorp; Diana van Heemst
Beta-galactosidase activity as a biomarker of replicative senescence during the course of human fibroblast cultures.
Annals of the New York Academy of Sciences 2007;1100():323-32.
2007: S Trompet; Douwe Pons; Anton J M de Craen; P Eline Slagboom; James Shepherd; Gerard J Blauw; Michael B. Murphy; Stuart M Cobbe; E L E M Bollen; Brendan M Buckley; Ian Ford; Michael Hyland; Allan Gaw; Peter W Macfarlane; Chris J Packard; John Norrie; Ivan J Perry; David J Stott; Brian J Sweeney; Cillian Twomey; Rudi G J Westendorp; J Wouter Jukema
Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events: the PROSPER study.
Annals of the New York Academy of Sciences 2007;1100():189-98.
2007: Simon P Mooijaart; Peter van Vliet; Diana van Heemst; Patrick Rensen; Jimmy F P Berbée; Jelle Jolles; Anton J M de Craen; Rudi G J Westendorp
Plasma levels of apolipoprotein E and cognitive function in old age.
Annals of the New York Academy of Sciences 2007;1100():148-61.
2007: Peter van Vliet; Simon P Mooijaart; Anton J M de Craen; Patrick Rensen; Diana van Heemst; Rudi G J Westendorp
Plasma levels of apolipoprotein E and risk of stroke in old age.
Annals of the New York Academy of Sciences 2007;1100():140-7.
2007: David Van Bodegom; Linda May; Hans J Meij; Rudi G J Westendorp
Regulation of human life histories: the role of the inflammatory host response.
Annals of the New York Academy of Sciences 2007;1100():84-97.
2007: Simon P Mooijaart; Maris Kuningas; Rudi G J Westendorp; Jeanine J Houwing-Duistermaat; P Eline Slagboom; Patrick Rensen; Diana van Heemst
Liver X receptor alpha associates with human life span.
The journals of gerontology. Series A, Biological sciences and medical sciences 2007;62(4):343-9.
2007: V Hester ten Dam; D M J van den Heuvel; Anton J M de Craen; E L E M Bollen; Heather M Murray; Rudi G J Westendorp; Gerard J Blauw; Mark A Van Buchem
Decline in total cerebral blood flow is linked with increase in periventricular but not deep white matter hyperintensities.
Radiology 2007;243(1):198-203.
2007: R van der Sande; Marcel G M Olde Rikkert; Rudi G J Westendorp; C van Weel
[Advice research on medical care for the elderly. Especially the elderly with multiple and complex problems].
Tijdschrift voor gerontologie en geriatrie 2007;38(1):46-8.
2007: Maris Kuningas; Reedik Mägi; Rudi G J Westendorp; P Eline Slagboom; Maido Remm; Diana van Heemst
Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age.
European journal of human genetics : EJHG 2007;15(3):294-301.
2007: Naveed Sattar; Heather M Murray; Alex McConnachie; Gerard J Blauw; E L E M Bollen; Brendan M Buckley; Stuart M Cobbe; Ian Ford; Allan Gaw; Michael Hyland; J Wouter Jukema; Adriaan M Kamper; Peter W Macfarlane; Michael B. Murphy; Chris J Packard; Ivan J Perry; David J Stott; Brian J Sweeney; Cillian Twomey; Rudi G J Westendorp; James Shepherd
C-reactive protein and prediction of coronary heart disease and global vascular events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER).
Circulation 2007;115(8):981-9.
2007: Andrea B Maier; Saskia Le Cessie; Corine de Koning-Treurniet; Johanna Blom; Rudi G J Westendorp; Diana van Heemst
Persistence of high-replicative capacity in cultured fibroblasts from nonagenarians.
Aging cell 2007;6(1):27-33.
2007: Karin van der Hiele; Alla A Vein; C G S Kramer; Robert H A M Reijntjes; Mark A Van Buchem; Rudi G J Westendorp; E L E M Bollen; J Gert van Dijk; H A M Middelkoop
Memory activation enhances EEG abnormality in mild cognitive impairment.
Neurobiology of aging 2007;28(1):85-90.
2006: Bas Heijmans; Marian Beekman; Jeanine J Houwing-Duistermaat; Mark R Cobain; Jonathan Powell; Gerard J Blauw; Frans van der Ouderaa; Rudi G J Westendorp; P Eline Slagboom
Lipoprotein particle profiles mark familial and sporadic human longevity.
PLoS medicine 2006;3(12):e495.
2006: FM van Dunné; Anton J M de Craen; Frans M Helmerhorst; Tom W J Huizinga; Rudi G J Westendorp
Interleukin-10 promoter polymorphisms in male and female fertility and fecundity.
Genes and immunity 2006;7(8):688-92.
2006: A C G M van Es; Wiesje M van der Flier; Faiza Admiraal-Behloul; Hans Olofsen; E L E M Bollen; H A M Middelkoop; Annelies W E Weverling-Rijnsburger; Rudi G J Westendorp; Mark A Van Buchem
Magnetization transfer imaging of gray and white matter in mild cognitive impairment and Alzheimer's disease.
Neurobiology of aging 2006;27(12):1757-62.
2006: David J Vinkers; Roos C van der Mast; Max L Stek; Rudi G J Westendorp; Jacobijn Gussekloo
[The relationship between atherosclerosis, cognitive impairment, and depression in old age].
Nederlands tijdschrift voor geneeskunde 2006;150(42):2307-11.
2006: Aart Spilt; Robbert J Goekoop; Rudi G J Westendorp; Gerard J Blauw; Anton J M de Craen; Mark A Van Buchem
Not all age-related white matter hyperintensities are the same: a magnetization transfer imaging study.
AJNR. American journal of neuroradiology 2006;27(9):1964-8.
2006: Thomas van Bemmel; Karen Woittiez; Gerard J Blauw; Femke van der Sman-de Beer; Friedo W Dekker; Rudi G J Westendorp; Jacobijn Gussekloo
Prospective study of the effect of blood pressure on renal function in old age: the Leiden 85-Plus Study.
Journal of the American Society of Nephrology : JASN 2006;17(9):2561-6.
2006: E van den Berg; Anton J M de Craen; Geert Jan Biessels; J Gussekloo; Rudi G J Westendorp
The impact of diabetes mellitus on cognitive decline in the oldest of the old: a prospective population-based study.
Diabetologia 2006;49(9):2015-23.
2006: Anton J M de Craen; Rudi G J Westendorp
Prognostic index for 4-year mortality in older adults.
JAMA : the journal of the American Medical Association 2006;296(6):648; author reply 648-9.
2006: Fotios Drenos; Rudi G J Westendorp; Thomas B L Kirkwood
Trade-off mediated effects on the genetics of human survival caused by increasingly benign living conditions.
Biogerontology 2006;7(4):287-95.
2006: Maris Kuningas; Simon P Mooijaart; P Eline Slagboom; Rudi G J Westendorp; Diana van Heemst
Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study.
Biogerontology 2006;7(4):231-8.
2006: Anton J M de Craen; Gerard J Blauw; Rudi G J Westendorp
Cholesterol and risk of stroke: cholesterol, stroke, and age.
BMJ (Clinical research ed.) 2006;333(7559):148.
2006: Anton J M de Craen; David J Stott; Rudi G J Westendorp
Homocysteine, B vitamins, and cardiovascular disease.
The New England journal of medicine 2006;355(2):205-6; author reply 209-11.
2006: Anton J M de Craen; Rudi G J Westendorp; Charles G Willems; Inge C M Buskens; Jacobijn Gussekloo
Assistive devices and community-based services among 85-year-old community-dwelling elderly in The Netherlands: ownership, use, and need for intervention.
Disability and rehabilitation. Assistive technology 2006;1(3):199-203.
2006: Rudi G J Westendorp
The art of autopsy--time for a renaissance.
The Netherlands journal of medicine 2006;64(6):164-5.
2006: Simon P Mooijaart; Jimmy F P Berbée; Diana van Heemst; Louis M Havekes; Anton J M de Craen; P Eline Slagboom; Patrick Rensen; Rudi G J Westendorp
ApoE plasma levels and risk of cardiovascular mortality in old age.
PLoS medicine 2006;3(6):e176.
2006: Rudi G J Westendorp; Gerbrand J Izaks
[Reference values for anaemia in the elderly].
Nederlands tijdschrift voor geneeskunde 2006;150(18):1002-6.
2006: Anton J M de Craen; Jacobijn Gussekloo; Gerard J Blauw; Charles G Willems; Rudi G J Westendorp
Randomised controlled trial of unsolicited occupational therapy in community-dwelling elderly people: the LOTIS trial.
PLoS clinical trials 2006;1(1):e2.
2006: D M J van den Heuvel; V Hester ten Dam; Anton J M de Craen; Faiza Admiraal-Behloul; A C G M van Es; Walter M Palm; Aart Spilt; E L E M Bollen; Gerard J Blauw; L Launer; Rudi G J Westendorp; Mark A Van Buchem
Measuring longitudinal white matter changes: comparison of a visual rating scale with a volumetric measurement.
AJNR. American journal of neuroradiology 2006;27(4):875-8.
2006: Marian Beekman; Gerard J Blauw; Jeanine J Houwing-Duistermaat; Bernd W Brandt; Rudi G J Westendorp; P Eline Slagboom
Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies.
The journals of gerontology. Series A, Biological sciences and medical sciences 2006;61(4):355-62.
2006: FM van Dunné; Anton J M de Craen; Bas Heijmans; Frans M Helmerhorst; Rudi G J Westendorp
Gender-specific association of the factor V Leiden mutation with fertility and fecundity in a historic cohort. The Leiden 85-Plus Study.
Human reproduction (Oxford, England) 2006;21(4):967-71.
2006: Maris Kuningas; P Eline Slagboom; Rudi G J Westendorp; Diana van Heemst
Impact of genetic variations in the WRN gene on age related pathologies and mortality.
Mechanisms of ageing and development 2006;127(3):307-13.
2006: Thomas van Bemmel; David J Vinkers; Peter W Macfarlane; Jacobijn Gussekloo; Rudi G J Westendorp
Markers of autonomic tone on a standard ECG are predictive of mortality in old age.
International journal of cardiology 2006;107(1):36-41.
2006: Thomas van Bemmel; Jacobijn Gussekloo; Rudi G J Westendorp; Gerard J Blauw
In a population-based prospective study, no association between high blood pressure and mortality after age 85 years.
Journal of hypertension 2006;24(2):287-92.
2006: Rudi G J Westendorp
What is healthy aging in the 21st century?
The American journal of clinical nutrition 2006;83(2):404S-409S.
2006: D M J van den Heuvel; V Hester ten Dam; Anton J M de Craen; Faiza Admiraal-Behloul; Hans Olofsen; E L E M Bollen; Jelle Jolles; Heather M Murray; Gerard J Blauw; Rudi G J Westendorp; Mark A Van Buchem
Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly population.
Journal of neurology, neurosurgery, and psychiatry 2006;77(2):149-53.
2006: Jacobijn Gussekloo; Eric van Exel; Anton J M de Craen; A Edo Meinders; Marijke Frölich; Rudi G J Westendorp
[Thyroid function, activities of daily living and survival in extreme old age: the 'Leiden 85-plus Study'].
Nederlands tijdschrift voor geneeskunde 2006;150(2):90-6.
2006: Max L Stek; David J Vinkers; Jacobijn Gussekloo; Roos C van der Mast; Aartjan T F Beekman; Rudi G J Westendorp
Natural history of depression in the oldest old: population-based prospective study.
The British journal of psychiatry : the journal of mental science 2006;188():65-9.
2006: Manja Schoenmaker; Anton J M de Craen; Paul H E M de Meijer; Marian Beekman; Gerard J Blauw; P Eline Slagboom; Rudi G J Westendorp
Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study.
European journal of human genetics : EJHG 2006;14(1):79-84.
2005: Anton J M de Craen; Rudi G J Westendorp
[The use of age as a variable in clinical research].
Nederlands tijdschrift voor geneeskunde 2005;149(53):2958-63.
2005: David J Stott; Graham MacIntosh; Gordon D O Lowe; Ann Rumley; Alex D McMahon; Peter Langhorne; R Campbell Tait; Denis St J O'Reilly; Edward G Spilg; Jonathan B MacDonald; Peter W Macfarlane; Rudi G J Westendorp
Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease.
The American journal of clinical nutrition 2005;82(6):1320-6.
2005: Carmen Martin-Ruiz; Jacobijn Gussekloo; Diana van Heemst; Thomas von Zglinicki; Rudi G J Westendorp
Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study.
Aging cell 2005;4(6):287-90.
2005: Chris J Packard; Ian Ford; Michele Robertson; James Shepherd; Gerard J Blauw; Michael B. Murphy; E L E M Bollen; Brendan M Buckley; Stuart M Cobbe; Allan Gaw; Michael Hyland; J Wouter Jukema; Adriaan M Kamper; Peter W Macfarlane; Ivan J Perry; David J Stott; Brian J Sweeney; Cillian Twomey; Rudi G J Westendorp
Plasma lipoproteins and apolipoproteins as predictors of cardiovascular risk and treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER).
Circulation 2005;112(20):3058-65.
2005: Wiesje M van der Flier; Annelies E van der Vlies; Annelies W E Weverling-Rijnsburger; Nel L de Boer; Faiza Admiraal-Behloul; E L E M Bollen; Rudi G J Westendorp; Mark A Van Buchem; H A M Middelkoop
MRI measures and progression of cognitive decline in nondemented elderly attending a memory clinic.
International journal of geriatric psychiatry 2005;20(11):1060-6.
2005: Simon P Mooijaart; Jacobijn Gussekloo; Marijke Frölich; Jelle Jolles; David J Stott; Rudi G J Westendorp; Anton J M de Craen
Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study.
The American journal of clinical nutrition 2005;82(4):866-71.
2005: Annetje Bootsma-Van Der Wiel; Anton J M de Craen; Eric van Exel; Peter W Macfarlane; Jacobijn Gussekloo; Rudi G J Westendorp
Association between chronic diseases and disability in elderly subjects with low and high income: the Leiden 85-plus Study.
European journal of public health 2005;15(5):494-7.
2005: Jacobijn Gussekloo; Anton J M de Craen; Charlène Oduber; Martin van Boxtel; Rudi G J Westendorp
Sensory impairment and cognitive functioning in oldest-old subjects: the Leiden 85+ Study.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2005;13(9):781-6.
2005: Aart Spilt; Annelies W E Weverling-Rijnsburger; H A M Middelkoop; Wiesje M van der Flier; Jacobijn Gussekloo; Anton J M de Craen; E L E M Bollen; Gerard J Blauw; Mark A Van Buchem; Rudi G J Westendorp
Late-onset dementia: structural brain damage and total cerebral blood flow.
Radiology 2005;236(3):990-5.
2005: Simon P Mooijaart; Bernd W Brandt; Egon A Baldal; Jeroen Pijpe; Maris Kuningas; Marian Beekman; Bas J Zwaan; P Eline Slagboom; Rudi G J Westendorp; Diana van Heemst
C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age.
Ageing research reviews 2005;4(3):351-71.
2005: V Hester ten Dam; Frieke M A Box; Anton J M de Craen; D M J van den Heuvel; E L E M Bollen; Heather M Murray; Mark A Van Buchem; Rudi G J Westendorp; Gerard J Blauw
Lack of effect of pravastatin on cerebral blood flow or parenchymal volume loss in elderly at risk for vascular disease.
Stroke; a journal of cerebral circulation 2005;36(8):1633-6.
2005: David J Vinkers; Max L Stek; Roos C van der Mast; Anton J M de Craen; S Le Cessie; Jelle Jolles; Rudi G J Westendorp; Jacobijn Gussekloo
Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age.
Neurology 2005;65(1):107-12.
2005: Martina F Mohrschladt; Femke van der Sman-de Beer; Maaike K Hofman; Marieke van der Krabben; Rudi G J Westendorp; August Smelt
TaqIB polymorphism in CETP gene: the influence on incidence of cardiovascular disease in statin-treated patients with familial hypercholesterolemia.
European journal of human genetics : EJHG 2005;13(7):877-82.
2005: Juventus Ziem; N Spannbrucker; Pascal Magnussen; Annette Olsen; D Nii Amon-Kotey; K Frenzel; A Nang-Beifubah; Rudi G J Westendorp; Anton M Polderman
Oesophagostomum bifurcum-induced nodular pathology in a highly endemic area of Northern Ghana.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2005;99(6):417-22.
2005: V Hester ten Dam; D M J van den Heuvel; Mark A Van Buchem; Rudi G J Westendorp; E L E M Bollen; Ian Ford; Anton J M de Craen; Gerard J Blauw
Effect of pravastatin on cerebral infarcts and white matter lesions.
Neurology 2005;64(10):1807-9.
2005: Danielle Posthuma; Ingrid Meulenbelt; Anton J M de Craen; Eco J C De Geus; P Eline Slagboom; Dorret I Boomsma; Rudi G J Westendorp
Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factors.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2005;8(2):132-7.
2005: Aart Spilt; Tychon Geeraedts; Anton J M de Craen; Rudi G J Westendorp; Gerard J Blauw; Mark A Van Buchem
Age-related changes in normal-appearing brain tissue and white matter hyperintensities: more of the same or something else?
AJNR. American journal of neuroradiology 2005;26(4):725-9.
2005: Diana van Heemst; Marian Beekman; Simon P Mooijaart; Bas Heijmans; Bernd W Brandt; Bas J Zwaan; P Eline Slagboom; Rudi G J Westendorp
Reduced insulin/IGF-1 signalling and human longevity.
Aging cell 2005;4(2):79-85.
2005: T van Bemmel; Rudi G J Westendorp
[Neuroleptic malignant syndrome in users of risperidone].
Nederlands tijdschrift voor geneeskunde 2005;149(11):608; author reply 608.
2005: Anton J M de Craen; Jacobijn Gussekloo; Roos C van der Mast; Saskia Le Cessie; Johanna W Lemkes; Rudi G J Westendorp
Seasonal mood variation in the elderly: the Leiden 85-plus study.
International journal of geriatric psychiatry 2005;20(3):269-73.
2005: Bernd W Brandt; Bas J Zwaan; Marian Beekman; Rudi G J Westendorp; P Eline Slagboom
Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family?
BioEssays : news and reviews in molecular, cellular and developmental biology 2005;27(3):339-46.
2005: Anton J M de Craen; Danielle Posthuma; Edmond J Remarque; Anita van den Biggelaar; Rudi G J Westendorp; Dorret I Boomsma
Heritability estimates of innate immunity: an extended twin study.
Genes and immunity 2005;6(2):167-70.
2005: Thomas B L Kirkwood; Martin Feder; Caleb E Finch; Claudio Franceschi; Amiela Globerson; Christian Peter Klingenberg; Kelly LaMarco; Stig W Omholt; Rudi G J Westendorp
What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?
Mechanisms of ageing and development 2005;126(3):439-43.
2005: Paul M Brakefield; David Gems; Tim Cowen; Kaare Christensen; Beatrix Grubeck-Loebenstein; Laurent Keller; Jim Oeppen; Angeles Rodriguez-Pena; Maria Antonietta Stazi; Marc Tatar; Rudi G J Westendorp
What are the effects of maternal and pre-adult environments on ageing in humans, and are there lessons from animal models?
Mechanisms of ageing and development 2005;126(3):431-8.
2005: Anton J M de Craen; Jacobijn Gussekloo; Bram Vrijsen; Rudi G J Westendorp
Meta-analysis of nonsteroidal antiinflammatory drug use and risk of dementia.
American journal of epidemiology 2005;161(2):114-20.
2005: David J Vinkers; Jacobijn Gussekloo; Max L Stek; Roos C van der Mast; Rudi G J Westendorp
Does depression specifically increase cardiovascular mortality?
Archives of internal medicine 2005;165(1):119; author reply 119-20.
2005: Adriaan M Kamper; Anton J M de Craen; Rudi G J Westendorp; Gerard J Blauw
Endothelium-dependent NO-mediated vasodilation in humans is attenuated by peripheral alpa1-adrenoceptor activation.
Vascular health and risk management 2005;1(3):251-6.
2005: Wiesje M van der Flier; H A M Middelkoop; Annelies W E Weverling-Rijnsburger; Faiza Admiraal-Behloul; E L E M Bollen; Rudi G J Westendorp; Mark A Van Buchem
Neuropsychological correlates of MRI measures in the continuum of cognitive decline at old age.
Dementia and geriatric cognitive disorders 2005;20(2-3):82-8.
2005: Diana van Heemst; Simon P Mooijaart; Marian Beekman; Jeroen Schreuder; Anton J M de Craen; Bernd W Brandt; P Eline Slagboom; Rudi G J Westendorp
Variation in the human TP53 gene affects old age survival and cancer mortality.
Experimental gerontology 2005;40(1-2):11-5.
2005: Thomas van Bemmel; Jan P Vandenbroucke; Rudi G J Westendorp; Jacobijn Gussekloo
In an observational study elderly patients had an increased risk of falling due to home hazards.
Journal of clinical epidemiology 2005;58(1):63-7.
2005: Max L Stek; David J Vinkers; Jacobijn Gussekloo; Aartjan T F Beekman; Roos C van der Mast; Rudi G J Westendorp
Is depression in old age fatal only when people feel lonely?
The American journal of psychiatry 2005;162(1):178-80.
2004: Jacobijn Gussekloo; Eric van Exel; Anton J M de Craen; A Edo Meinders; Marijke Frölich; Rudi G J Westendorp
Thyroid status, disability and cognitive function, and survival in old age.
JAMA : the journal of the American Medical Association 2004;292(21):2591-9.
2004: D M J van den Heuvel; Faiza Admiraal-Behloul; V Hester ten Dam; Hans Olofsen; E L E M Bollen; Heather M Murray; Gerard J Blauw; Rudi G J Westendorp; Anton J M de Craen; Mark A Van Buchem
Different progression rates for deep white matter hyperintensities in elderly men and women.
Neurology 2004;63(9):1699-701.
2004: David J Vinkers; Jacobijn Gussekloo; Max L Stek; Rudi G J Westendorp; Roos C van der Mast
Temporal relation between depression and cognitive impairment in old age: prospective population based study.
BMJ (Clinical research ed.) 2004;329(7471):881.
2004: Anita van den Biggelaar; Tom W J Huizinga; Anton J M de Craen; Jacobijn Gussekloo; Bas Heijmans; Marijke Frölich; Rudi G J Westendorp
Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study.
Experimental gerontology 2004;39(9):1407-14.
2004: David J Vinkers; Max L Stek; Jacobijn Gussekloo; Roos C van der Mast; Rudi G J Westendorp
Does depression in old age increase only cardiovascular mortality? The Leiden 85-plus Study.
International journal of geriatric psychiatry 2004;19(9):852-7.
2004: Adriaan M Kamper; Aart Spilt; Anton J M de Craen; Mark A Van Buchem; Rudi G J Westendorp; Gerard J Blauw
Basal cerebral blood flow is dependent on the nitric oxide pathway in elderly but not in young healthy men.
Experimental gerontology 2004;39(8):1245-8.
2004: Wiesje M van der Flier; Mark A Van Buchem; Annelies W E Weverling-Rijnsburger; Elisabeth R Mutsaers; E L E M Bollen; Faiza Admiraal-Behloul; Rudi G J Westendorp; H A M Middelkoop
Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes.
Journal of neurology 2004;251(6):671-5.
2004: Maarten T Bastiaens; Juliette J Hoefnagel; Rudi G J Westendorp; Bert-Jan Vermeer; Jan N Bouwes Bavinck
Solar lentigines are strongly related to sun exposure in contrast to ephelides.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2004;17(3):225-9.
2004: Anita van den Biggelaar; Anton J M de Craen; Jacobijn Gussekloo; Tom W J Huizinga; Bas Heijmans; Marijke Frölich; Tom B L Kirkwood; Rudi G J Westendorp
Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(9):1022-4.
2004: Wiesje M van der Flier; H A M Middelkoop; Annelies W E Weverling-Rijnsburger; Faiza Admiraal-Behloul; Aart Spilt; E L E M Bollen; Rudi G J Westendorp; Mark A Van Buchem
Interaction of medial temporal lobe atrophy and white matter hyperintensities in AD.
Neurology 2004;62(10):1862-4.
2004: Jacobijn Gussekloo; Anton J M de Craen; Eric van Exel; Annetje Bootsma-Van Der Wiel; Rudi G J Westendorp
[Causes and consequences of cognitive decline in the very elderly; the 'Leiden 85-plus Study'].
Nederlands tijdschrift voor geneeskunde 2004;148(20):979-83.
2004: Max L Stek; J Gussekloo; Aartjan T F Beekman; Willem van Tilburg; Rudi G J Westendorp
Prevalence, correlates and recognition of depression in the oldest old: the Leiden 85-plus study.
Journal of affective disorders 2004;78(3):193-200.
2004: Simon P Mooijaart; Diana van Heemst; Jeroen Schreuder; Suzan van Gerwen; Marian Beekman; Bernd W Brandt; P Eline Slagboom; Rudi G J Westendorp
Variation in the SHC1 gene and longevity in humans.
Experimental gerontology 2004;39(2):263-8.
2004: Martina F Mohrschladt; Rudi G J Westendorp; Jan A Gevers Leuven; August Smelt
Cardiovascular disease and mortality in statin-treated patients with familial hypercholesterolemia.
Atherosclerosis 2004;172(2):329-35.
2004: Johanna A Kremer-Hovinga; Rendrik F Franco; Marco Zago; Hugo ten Cate; Rudi G J Westendorp; Pieter H Reitsma
A functional single nucleotide polymorphism in the thrombin-activatable fibrinolysis inhibitor (TAFI) gene associates with outcome of meningococcal disease.
Journal of thrombosis and haemostasis : JTH 2004;2(1):54-7.
2004: David J Vinkers; Jacobijn Gussekloo; Max L Stek; Rudi G J Westendorp; Roos C van der Mast
The 15-item Geriatric Depression Scale (GDS-15) detects changes in depressive symptoms after a major negative life event. The Leiden 85-plus Study.
International journal of geriatric psychiatry 2004;19(1):80-4.
2004: Rudi G J Westendorp
Are we becoming less disposable?
EMBO reports 2004;5(1):2-6.
2003: Eric van Exel; Anton J M de Craen; Edmond J Remarque; Jacobijn Gussekloo; Peter Houx; Annetje Bootsma-Van Der Wiel; Marijke Frölich; Peter W Macfarlane; Gerard J Blauw; Rudi G J Westendorp
Interaction of atherosclerosis and inflammation in elderly subjects with poor cognitive function.
Neurology 2003;61(12):1695-701.
2003: Gerbrand J Izaks; Rudi G J Westendorp
Ill or just old? Towards a conceptual framework of the relation between ageing and disease.
BMC geriatrics 2003;3():7.
2003: David J Vinkers; Jacobijn Gussekloo; Roos C van der Mast; Frans Zitman; Rudi G J Westendorp
Benzodiazepine use and risk of mortality in individuals aged 85 years or older.
JAMA : the journal of the American Medical Association 2003;290(22):2942-3.
2003: Linda Struijk; Jan N Bouwes Bavinck; Patrick Wanningen; Els van der Meijden; Rudi G J Westendorp; Jan ter Schegget; Mariet C W Feltkamp
Presence of human papillomavirus DNA in plucked eyebrow hairs is associated with a history of cutaneous squamous cell carcinoma.
The Journal of investigative dermatology 2003;121(6):1531-5.
2003: Meindert A van Dijk; Martijn H Breuning; Rik Duiser; Leendert A Van Es; Rudi G J Westendorp
No effect of enalapril on progression in autosomal dominant polycystic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2003;18(11):2314-20.
2003: Annetje Bootsma-Van Der Wiel; Jacobijn Gussekloo; Anton J M de Craen; Eric van Exel; Bastiaan R Bloem; Rudi G J Westendorp
Walking and talking as predictors of falls in the general population: the Leiden 85-Plus Study.
Journal of the American Geriatrics Society 2003;51(10):1466-71.
2003: Gerbrand J Izaks; Edmond J Remarque; Sander V Becker; Rudi G J Westendorp
Lymphocyte count and mortality risk in older persons. The Leiden 85-Plus Study.
Journal of the American Geriatrics Society 2003;51(10):1461-5.
2003: David J Vinkers; Jacobijn Gussekloo; Rudi G J Westendorp
Leisure activities and the risk of dementia.
The New England journal of medicine 2003;349(13):1290-2; author reply 1290-2.
2003: Anton J M de Craen; M O van Aken; Rudi G J Westendorp
[The prioritisation of genetic screening with primary haemochromatosis as an example].
Nederlands tijdschrift voor geneeskunde 2003;147(30):1442-5.
2003: Anton J M de Craen; Jacobijn Gussekloo; Y K O Teng; P W Macfarlane; Rudi G J Westendorp
Prevalence of five common clinical abnormalities in very elderly people: population based cross sectional study.
BMJ (Clinical research ed.) 2003;327(7407):131-2.
2003: Annelies W E Weverling-Rijnsburger; Iris J A M Jonkers; Eric van Exel; Jacobijn Gussekloo; Rudi G J Westendorp
High-density vs low-density lipoprotein cholesterol as the risk factor for coronary artery disease and stroke in old age.
Archives of internal medicine 2003;163(13):1549-54.
2003: Darian P Shackleton; Dorothée G A Kasteleijn-Nolst Trenité; Anton J M de Craen; J P Vandenbroucke; Rudi G J Westendorp
Living with epilepsy: long-term prognosis and psychosocial outcomes.
Neurology 2003;61(1):64-70.
2003: Leroy R Lard; Floris A van Gaalen; J J M Schonkeren; Elsbet Pieterman; G Stoeken; Koen Vos; Rob G H H Nelissen; Rudi G J Westendorp; Rob Hoeben; Ferdinand C Breedveld; René E M Toes; Tom W J Huizinga
Association of the -2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis.
Arthritis and rheumatism 2003;48(7):1841-8.
2003: W-Ludo van der Pol; Marc D Jansen; Wim J Sluiter; Bart van De Sluis; F G J Leppers-van de Straat; Tetsuo Kobayashi; Rudi G J Westendorp; Tom W J Huizinga; Jan G J van de Winkel
Evidence for non-random distribution of Fcgamma receptor genotype combinations.
Immunogenetics 2003;55(4):240-6.
2003: Mariet C W Feltkamp; René Broer; Franca M di Summa; Linda Struijk; Els van der Meijden; Bert P J Verlaan; Rudi G J Westendorp; Jan ter Schegget; Willy Spaan; Jan N Bouwes Bavinck
Seroreactivity to epidermodysplasia verruciformis-related human papillomavirus types is associated with nonmelanoma skin cancer.
Cancer research 2003;63(10):2695-700.
2003: Mattheus H J de Bruijne; Yvo W J Sijpkens; Leendert C Paul; Rudi G J Westendorp; Hans C van Houwelingen; Aeilko H Zwinderman
Predicting kidney graft failure using time-dependent renal function covariates.
Journal of clinical epidemiology 2003;56(5):448-55.
2003: Cornelis Kennedy; Maarten T Bastiaens; Chris D Bajdik; Rein Willemze; Rudi G J Westendorp; Jan N Bouwes Bavinck
Effect of smoking and sun on the aging skin.
The Journal of investigative dermatology 2003;120(4):548-54.
2003: G J Izaks; Rudi G J Westendorp
[Osteoporosis in elderly women should always be treated, despite the new professional guideline from the Dutch Institute for Health Care Improvement (CBO)].
Nederlands tijdschrift voor geneeskunde 2003;147(13):588-90.
2003: Bas Heijmans; Judith M Boer; H Eka D Suchiman; Cees J Cornelisse; Rudi G J Westendorp; Daan Kromhout; Edith J M Feskens; P Eline Slagboom
A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer.
Cancer research 2003;63(6):1249-53.
2002: Eric van Exel; Jacobijn Gussekloo; Peter Houx; Anton J M de Craen; Peter W Macfarlane; Annetje Bootsma-Van Der Wiel; Gerard J Blauw; Rudi G J Westendorp
Atherosclerosis and cognitive impairment are linked in the elderly. The Leiden 85-plus Study.
Atherosclerosis 2002;165(2):353-9.
2002: James Shepherd; Gerard J Blauw; Michael B. Murphy; E L E M Bollen; Brendan M Buckley; Stuart M Cobbe; Ian Ford; Allan Gaw; Michael Hyland; J Wouter Jukema; Adriaan M Kamper; Peter W Macfarlane; A Edo Meinders; John Norrie; Chris J Packard; Ivan J Perry; David J Stott; Brian J Sweeney; Cillian Twomey; Rudi G J Westendorp
Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial.
Lancet 2002;360(9346):1623-30.
2002: A Bootsma-van der Wiel; Eric van Exel; Anton J M de Craen; Jacobijn Gussekloo; A Margot Lagaay; Dick L Knook; Rudi G J Westendorp
A high response is not essential to prevent selection bias: results from the Leiden 85-plus study.
Journal of clinical epidemiology 2002;55(11):1119-25.
2002: Tom W J Huizinga; Suzanne Linn-Rasker; Leroy R Lard; Rudi G J Westendorp
Genetic drift as an explanation for the reduced incidence of rheumatoid arthritis.
Arthritis and rheumatism 2002;46(11):3107.
2002: Anton J M de Craen; Tom W J Huizinga; Rudi G J Westendorp
Multiple sclerosis and type 1 diabetes in Sardinia.
Lancet 2002;360(9341):1253.
2002: M O Van Aken; Anton J M de Craen; Jacobijn Gussekloo; Payman Hanifi Moghaddam; J P Vandenbroucke; Bas Heijmans; P Eline Slagboom; Rudi G J Westendorp
No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus study.
European journal of clinical investigation 2002;32(10):750-4.
2002: Peter Houx; James Shepherd; Gerard J Blauw; Michael B. Murphy; Ian Ford; E L E M Bollen; Brendan M Buckley; David J Stott; W Jukema; Michael Hyland; Allan Gaw; John Norrie; Adriaan M Kamper; Ivan J Perry; Peter W Macfarlane; A Edo Meinders; Brian J Sweeney; Chris J Packard; Cillian Twomey; Stuart M Cobbe; Rudi G J Westendorp
Testing cognitive function in elderly populations: the PROSPER study. PROspective Study of Pravastatin in the Elderly at Risk.
Journal of neurology, neurosurgery, and psychiatry 2002;73(4):385-9.
2002: Wiesje M van der Flier; D M J van den Heuvel; Annelies W E Weverling-Rijnsburger; Aart Spilt; E L E M Bollen; Rudi G J Westendorp; H A M Middelkoop; Mark A Van Buchem
Cognitive decline in AD and mild cognitive impairment is associated with global brain damage.
Neurology 2002;59(6):874-9.
2002: Brigit A de Jong; Tom W J Huizinga; Eric Zanelli; Marius J Giphart; E L E M Bollen; Bernard Uitdehaag; Chris H Polman; Rudi G J Westendorp
Evidence for additional genetic risk indicators of relapse-onset MS within the HLA region.
Neurology 2002;59(4):549-55.
2002: Max L Stek; Eric van Exel; Willem van Tilburg; Rudi G J Westendorp; Aartjan T F Beekman
The prognosis of depression in old age: outcome six to eight years after clinical treatment.
Aging & mental health 2002;6(3):282-5.
2002: Annetje Bootsma-Van Der Wiel; Jacobijn Gussekloo; Anton J M de Craen; Eric van Exel; Bastiaan R Bloem; Rudi G J Westendorp
Common chronic diseases and general impairments as determinants of walking disability in the oldest-old population.
Journal of the American Geriatrics Society 2002;50(8):1405-10.
2002: Wiesje M van der Flier; D M J van den Heuvel; Annelies W E Weverling-Rijnsburger; E L E M Bollen; Rudi G J Westendorp; Mark A Van Buchem; H A M Middelkoop
Magnetization transfer imaging in normal aging, mild cognitive impairment, and Alzheimer's disease.
Annals of neurology 2002;52(1):62-7.
2002: Eric van Exel; Anton J M de Craen; Jacobijn Gussekloo; Peter Houx; Annetje Bootsma-Van Der Wiel; Peter W Macfarlane; Gerard J Blauw; Rudi G J Westendorp
Association between high-density lipoprotein and cognitive impairment in the oldest old.
Annals of neurology 2002;51(6):716-21.
2002: Bas Heijmans; Rudi G J Westendorp; Simone Droog; Cornelis Kluft; Dick L Knook; P Eline Slagboom
Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort.
Genes and immunity 2002;3(4):225-8.
2002: Brigit A de Jong; Tom W J Huizinga; E L E M Bollen; Bernard Uitdehaag; Gerlof P Th Bosma; Mark A Van Buchem; Edmond J Remarque; Alexandra C S Burgmans; Nynke F Kalkers; Chris H Polman; Rudi G J Westendorp
Production of IL-1beta and IL-1Ra as risk factors for susceptibility and progression of relapse-onset multiple sclerosis.
Journal of neuroimmunology 2002;126(1-2):172-9.
2002: Rudi G J Westendorp
Leiden research program on ageing.
Experimental gerontology 2002;37(5):609-14.
2002: Brigit A de Jong; Rudi G J Westendorp; Joyce Eskdale; Bernard Uitdehaag; Tom W J Huizinga
Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary progressive multiple sclerosis.
Human immunology 2002;63(4):281-5.
2002: Darian P Shackleton; Rudi G J Westendorp; Dorothée G A Kasteleijn-Nolst Trenité; Anton J M de Craen; Jan P Vandenbroucke
Survival of patients with epilepsy: an estimate of the mortality risk.
Epilepsia 2002;43(4):445-50.
2002: Eric van Exel; Jacobijn Gussekloo; Anton J M de Craen; Annetje Bootsma-Van Der Wiel; Marijke Frölich; Rudi G J Westendorp
Inflammation and stroke: the Leiden 85-Plus Study .
Stroke; a journal of cerebral circulation 2002;33(4):1135-8.
2002: Eric van Exel; Jacobijn Gussekloo; Anton J M de Craen; Marijke Frölich; Annetje Bootsma-Van Der Wiel; Rudi G J Westendorp
Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study.
Diabetes 2002;51(4):1088-92.
2002: Annette H M Van Mil; Aart Spilt; Mark A Van Buchem; E L E M Bollen; Luc Teppema; Rudi G J Westendorp; Gerard J Blauw
Nitric oxide mediates hypoxia-induced cerebral vasodilation in humans.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;92(3):962-6.
2002: Brigit A de Jong; Rudi G J Westendorp; A M Bakker; Tom W J Huizinga
Polymorphisms in or near tumour necrosis factor (TNF)-gene do not determine levels of endotoxin-induced TNF production.
Genes and immunity 2002;3(1):25-9.
2002: Bas Heijmans; P Eline Slagboom; Jacobijn Gussekloo; Simone Droog; A Margot Lagaay; Cornelis Kluft; Dick L Knook; Rudi G J Westendorp
Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age.
American journal of medical genetics 2002;107(3):201-8.
2001: W-Ludo van der Pol; Tom W J Huizinga; Gestur Vidarsson; Michiel W van der Linden; Marc D Jansen; Vivian Keijsers; F G de Straat; NA Westerdaal; J G de Winkel; Rudi G J Westendorp
Relevance of Fcgamma receptor and interleukin-10 polymorphisms for meningococcal disease.
The Journal of infectious diseases 2001;184(12):1548-55.
2001: M von Faber; Annetje Bootsma-Van Der Wiel; Eric van Exel; Jacobijn Gussekloo; A Margot Lagaay; E van Dongen; Dick L Knook; S van der Geest; Rudi G J Westendorp
Successful aging in the oldest old: Who can be characterized as successfully aged?
Archives of internal medicine 2001;161(22):2694-700.
2001: Annelies W E Weverling-Rijnsburger; Gerard J Blauw; Rudi G J Westendorp
Cholesterol and all-cause mortality in Honolulu.
Lancet 2001;358(9296):1905-6.
2001: Gerard J Blauw; E L E M Bollen; Mark A Van Buchem; Rudi G J Westendorp
Dementia at old age: a clinical end-point of atherosclerotic disease.
European heart journal 2001;3 Suppl N():N16-9.
2001: Michiel W van der Linden; Arno R van der Slik; Eric Zanelli; Marius J Giphart; Elsbet Pieterman; G M Th Schreuder; Rudi G J Westendorp; Tom W J Huizinga
Six microsatellite markers on the short arm of chromosome 6 in relation to HLA-DR3 and TNF-308A in systemic lupus erythematosus.
Genes and immunity 2001;2(7):373-80.
2001: V Hester ten Dam; E L E M Bollen; Rudi G J Westendorp; A E Meinders; Gerard J Blauw
[Role of statins in prevention of stroke and dementia].
Nederlands tijdschrift voor geneeskunde 2001;145(40):1918-21.
2001: Maarten T Bastiaens; Jeanet A C ter Huurne; Nelleke A Gruis; Wilma Bergman; Rudi G J Westendorp; Bert-Jan Vermeer; Jan N Bouwes Bavinck
The melanocortin-1-receptor gene is the major freckle gene.
Human molecular genetics 2001;10(16):1701-8.
2001: Martina F Mohrschladt; Moniek P M de Maat; Rudi G J Westendorp; August Smelt
C-reactive protein in patients with familial hypercholesterolemia: no effect of simvastatin therapy.
Atherosclerosis 2001;157(2):491-4.
2001: Annetje Bootsma-Van Der Wiel; Jacobijn Gussekloo; Anton J M de Craen; Eric van Exel; Dick L Knook; A Margot Lagaay; Rudi G J Westendorp
Disability in the oldest old: "can do" or "do do"?
Journal of the American Geriatrics Society 2001;49(7):909-14.
2001: Eric van Exel; Jacobijn Gussekloo; Anton J M de Craen; Annetje Bootsma-Van Der Wiel; Peter Houx; Dick L Knook; Rudi G J Westendorp
Cognitive function in the oldest old: women perform better than men.
Journal of neurology, neurosurgery, and psychiatry 2001;71(1):29-32.
2001: J E Portielje; Rudi G J Westendorp; Hanneke C Kluin-Nelemans; Anneke Brand
Morbidity and mortality in adults with idiopathic thrombocytopenic purpura.
Blood 2001;97(9):2549-54.
2001: Maarten T Bastiaens; Jeanet A C ter Huurne; C Kielich; Nelleke A Gruis; Rudi G J Westendorp; Bert-Jan Vermeer; Jan Nico Bouwes Bavinck
Melanocortin-1 receptor gene variants determine the risk of nonmelanoma skin cancer independently of fair skin and red hair.
American journal of human genetics 2001;68(4):884-94.
2001: D G Roos-Van Eijndhoven; HJ Cools; Rudi G J Westendorp; A J Ten Cate-Hoek; Dick L Knook; Edmond J Remarque
Randomized controlled trial of seroresponses to double dose and booster influenza vaccination in frail elderly subjects.
Journal of medical virology 2001;63(4):293-8.
2001: Michiel W van der Linden; T van Lopik; Lucien A Aarden; Rudi G J Westendorp; Tom W J Huizinga
Soluble CD95 concentrations are increased in patients with severe systemic lupus erythematosus, but not in their first degree relatives.
Annals of the rheumatic diseases 2001;60(3):237-41.
2001: Yvo W J Sijpkens; Marko J K Mallat; CE Siegert; A H Zwinderman; Rudi G J Westendorp; Johan W de Fijter; Leendert A Van Es; Leendert C Paul
Risk factors of cyclosporine nephrotoxicity after conversion from Sandimmune to Neoral.
Clinical nephrology 2001;55(2):149-55.
2001: Michiel W van der Linden; Rudi G J Westendorp; Majida Zidane; L Meheus; Tom W J Huizinga
Autoantibodies within families of patients with systemic lupus erythematosus are not directed against the same nuclear antigens.
The Journal of rheumatology 2001;28(2):284-7.
2001: Eric van Exel; Rudi G J Westendorp; Max L Stek; Willem van Tilburg; Aartjan T F Beekman; Anton J M de Craen
Patients with late-onset depression have poor cognitive function at old age.
Journal of the American Geriatrics Society 2001;49(2):231-3.
2001: Maarten T Bastiaens; L Struyk; SP Tjong-A-Hung; Nelleke A Gruis; Jeanet A C ter Huurne; Rudi G J Westendorp; Bert-Jan Vermeer; Jan Nico Bouwes Bavinck; Jan ter Schegget
Cutaneous squamous cell carcinoma and p53 codon 72 polymorphism: a need for screening?
Molecular carcinogenesis 2001;30(1):56-61.
2001: Edmond J Remarque; E L E M Bollen; Annelies W E Weverling-Rijnsburger; J C Laterveer; Gerard J Blauw; Rudi G J Westendorp
Patients with Alzheimer's disease display a pro-inflammatory phenotype.
Experimental gerontology 2001;36(1):171-6.
2001: C A Wensveen; Maarten T Bastiaens; C J Kielich; M J Berkhout; Rudi G J Westendorp; Bert-Jan Vermeer; Jan N Bouwes Bavinck
Relation between smoking and skin cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(1):231-8.
2000: Q Ouyang; G Cicek; Rudi G J Westendorp; HJ Cools; R J van der Klis; Edmond J Remarque
Reduced IFN-gamma production in elderly people following in vitro stimulation with influenza vaccine and endotoxin.
Mechanisms of ageing and development 2000;121(1-3):131-7.
2000: Martina F Mohrschladt; August Smelt; Rudi G J Westendorp
Endotoxin-lipoprotein hypothesis.
Lancet 2000;356(9247):2097.
2000: P van Langevelde; K Joop; J van Loon; Marijke Frölich; Paul H P Groeneveld; Rudi G J Westendorp; Jaap T van Dissel
Endotoxin, cytokines, and procalcitonin in febrile patients admitted to the hospital: identification of subjects at high risk of mortality.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2000;31(6):1343-8.
2000: Tom W J Huizinga; Vivian Keijsers; Ghada Yanni; M Hall; W Ramage; J Lanchbury; Costantino Pitzalis; W K Drossaers-Bakker; Rudi G J Westendorp; Ferdinand C Breedveld; Gabriel S Panayi; Cornelis L Verweij
Are differences in interleukin 10 production associated with joint damage?
Rheumatology (Oxford, England) 2000;39(11):1180-8.
2000: A M Bour; Rudi G J Westendorp; J C Laterveer; E L E M Bollen; Edmond J Remarque
Interaction of indomethacin with cytokine production in whole blood. Potential mechanism for a brain-protective effect.
Experimental gerontology 2000;35(8):1017-24.
2000: Annette H M Van Mil; Rik C J van Klink; C Huntjens; Rudi G J Westendorp; Anne M Stiggelbout; A Edo Meinders; A Margot Lagaay
Cardiopulmonary resuscitation preferences in Dutch community-dwelling and hospitalized elderly people: an interaction between gender and quality of life.
Medical decision making : an international journal of the Society for Medical Decision Making 2000;20(4):423-9.
2000: Brigit A de Jong; Hans M Schrijver; Tom W J Huizinga; E L E M Bollen; Chris H Polman; Bernard Uitdehaag; M C Kersbergen; A Sturk; Rudi G J Westendorp
Innate production of interleukin-10 and tumor necrosis factor affects the risk of multiple sclerosis.
Annals of neurology 2000;48(4):641-6.
2000: Bastiaan R Bloem; Jacobijn Gussekloo; A Margot Lagaay; Edmond J Remarque; Joost Haan; Rudi G J Westendorp
Idiopathic senile gait disorders are signs of subclinical disease.
Journal of the American Geriatrics Society 2000;48(9):1098-101.
2000: Michiel W van der Linden; Rudi G J Westendorp; Augueste Sturk; Wilma Bergman; Tom W J Huizinga
High interleukin-10 production in first-degree relatives of patients with generalized but not cutaneous lupus erythematosus.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2000;48(5):327-34.
2000: Jan Nico Bouwes Bavinck; Maarten T Bastiaens; M E Marugg; R C Beckers; Rudi G J Westendorp; Bert-Jan Vermeer; Frans H J Claas
Further evidence for an association of HLA-DR7 with basal cell carcinoma on the tropical island of Saba.
Archives of dermatology 2000;136(8):1019-22.
2000: P Eline Slagboom; Bas Heijmans; Marian Beekman; Rudi G J Westendorp; Ingrid Meulenbelt
Genetics of human aging. The search for genes contributing to human longevity and diseases of the old.
Annals of the New York Academy of Sciences 2000;908():50-63.
2000: Gerbrand J Izaks; Edmond J Remarque; G M Schreuder; Rudi G J Westendorp; Gerard Ligthart
The effect of geographic origin on the frequency of HLA antigens and their association with ageing.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 2000;27(2):87-92.
2000: Eric J G Sijbrands; Rudi G J Westendorp; M Paola Lombardi; Louis M Havekes; Rune R Frants; John J P Kastelein; August Smelt
Additional risk factors influence excess mortality in heterozygous familial hypercholesterolaemia.
Atherosclerosis 2000;149(2):421-5.
2000: Bas Heijmans; Rudi G J Westendorp; A Margot Lagaay; Dick L Knook; Cornelis Kluft; P Eline Slagboom
Common paraoxonase gene variants, mortality risk and fatal cardiovascular events in elderly subjects.
Atherosclerosis 2000;149(1):91-7.
2000: Martina F Mohrschladt; Annelies W E Weverling-Rijnsburger; Frits H A F de Man; Dirk-Jan Stoeken; Augueste Sturk; August Smelt; Rudi G J Westendorp
Hyperlipoproteinemia affects cytokine production in whole blood samples ex vivo. The influence of lipid-lowering therapy.
Atherosclerosis 2000;148(2):413-9.
2000: Rienk Nieuwland; René Berckmans; S McGregor; Anita N Böing; Fred P H T M Romijn; Rudi G J Westendorp; C Erik Hack; Augueste Sturk
Cellular origin and procoagulant properties of microparticles in meningococcal sepsis.
Blood 2000;95(3):930-5.
2000: L M de Jong-Tieben; Ron J M Berkhout; Jan ter Schegget; Bert-Jan Vermeer; Johan W de Fijter; Jan A Bruijn; Rudi G J Westendorp; Jan N Bouwes Bavinck
The prevalence of human papillomavirus DNA in benign keratotic skin lesions of renal transplant recipients with and without a history of skin cancer is equally high: a clinical study to assess risk factors for keratotic skin lesions and skin cancer.
Transplantation 2000;69(1):44-9.
2000: Annette H M Van Mil; Rudi G J Westendorp; E L E M Bollen; A Margot Lagaay; Gerard J Blauw
HMG-CoA reductase inhibitors in the prevention of stroke.
Drugs 2000;59(1):1-6.
2000: Jan N Bouwes Bavinck; Sabine Stark; A K Petridis; M E Marugg; Jan ter Schegget; Rudi G J Westendorp; Pawel G Fuchs; Bert-Jan Vermeer; Herbert Pfister
The presence of antibodies against virus-like particles of epidermodysplasia verruciformis-associated humanpapillomavirus type 8 in patients with actinic keratoses.
The British journal of dermatology 2000;142(1):103-9.
2000: Maarten J Rood; Michiel V van Krugten; Eric Zanelli; Michiel W van der Linden; Vivian Keijsers; G M Th Schreuder; Willem Verduyn; Rudi G J Westendorp; René R P De Vries; Ferdinand C Breedveld; Cornelis L Verweij; Tom W J Huizinga
TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus.
Arthritis and rheumatism 2000;43(1):129-34.
1999: James Shepherd; Gerard J Blauw; Michael B. Murphy; Stuart M Cobbe; E L E M Bollen; Brendan M Buckley; Ian Ford; J Wouter Jukema; Michael Hyland; Allan Gaw; A Margot Lagaay; Ivan J Perry; Peter W Macfarlane; A Edo Meinders; Brian J Sweeney; Chris J Packard; Rudi G J Westendorp; Cillian Twomey; David J Stott
The design of a prospective study of Pravastatin in the Elderly at Risk (PROSPER). PROSPER Study Group. PROspective Study of Pravastatin in the Elderly at Risk.
The American journal of cardiology 1999;84(10):1192-7.
1999: Yvo W J Sijpkens; Ilias Doxiadis; Johan W de Fijter; Marko J K Mallat; Leendert A Van Es; Peter De Lange; Aeilko H Zwinderman; Rudi G J Westendorp; Folkert J van Kemenade; Jan A Bruijn; Frans H J Claas; Leendert C Paul
Sharing cross-reactive groups of MHC class I improves long-term graft survival.
Kidney international 1999;56(5):1920-7.
1999: Maarten T Bastiaens; Rudi G J Westendorp; Bert-Jan Vermeer; Jan Nico Bouwes Bavinck
Ephelides are more related to pigmentary constitutional host factors than solar lentigines.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1999;12(5):316-22.
1999: Bas Heijmans; Rudi G J Westendorp; Dick L Knook; Cornelis Kluft; P Eline Slagboom
Angiotensin I-converting enzyme and plasminogen activator inhibitor-1 gene variants: risk of mortality and fatal cardiovascular disease in an elderly population-based cohort.
Journal of the American College of Cardiology 1999;34(4):1176-83.
1999: Jacobijn Gussekloo; Bas Heijmans; P Eline Slagboom; A Margot Lagaay; Dick L Knook; Rudi G J Westendorp
Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85.
Journal of neurology, neurosurgery, and psychiatry 1999;67(4):535-8.
1999: Rudi G J Westendorp; Jouke-Jan Hottenga; P Eline Slagboom
Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock.
Lancet 1999;354(9178):561-3.
1999: Yves F C Smets; Rudi G J Westendorp; Johan W van der Pijl; Frank Th de Charro; Jan Ringers; Johan W de Fijter; Herman H P J Lemkes
Effect of simultaneous pancreas-kidney transplantation on mortality of patients with type-1 diabetes mellitus and end-stage renal failure.
Lancet 1999;353(9168):1915-9.
1999: Gerbrand J Izaks; Rudi G J Westendorp; Dick L Knook
The definition of anemia in older persons.
JAMA : the journal of the American Medical Association 1999;281(18):1714-7.
1999: Darian P Shackleton; Rudi G J Westendorp; Dorothée G A Kasteleijn-Nolst Trenité; Jan P Vandenbroucke
Mortality in patients with epilepsy: 40 years of follow up in a Dutch cohort study.
Journal of neurology, neurosurgery, and psychiatry 1999;66(5):636-40.
1999: Louis-Jean Vleming; Johan W van der Pijl; Herman H P J Lemkes; Rudi G J Westendorp; J Antonie Maassen; Mohamed R Daha; Leendert A Van Es; Cees van Kooten
The DD genotype of the ACE gene polymorphism is associated with progression of diabetic nephropathy to end stage renal failure in IDDM.
Clinical nephrology 1999;51(3):133-40.
1999: Bas Heijmans; Jacobijn Gussekloo; Cornelis Kluft; Simone Droog; A Margot Lagaay; Dick L Knook; Rudi G J Westendorp; E P Slagboom
Mortality risk in men is associated with a common mutation in the methylene-tetrahydrofolate reductase gene (MTHFR).
European journal of human genetics : EJHG 1999;7(2):197-204.
1999: Walter Emil Philipp Beyer; Iris de Bruijn; Abraham M Palache; Rudi G J Westendorp; Albert D M E Osterhaus
Protection against influenza after annually repeated vaccination: a meta-analysis of serologic and field studies.
Archives of internal medicine 1999;159(2):182-8.
1999: Iris de Bruijn; Edmond J Remarque; CM Jol-van der Zijde; Maarten J D van Tol; Rudi G J Westendorp; Dick L Knook
Quality and quantity of the humoral immune response in healthy elderly and young subjects after annually repeated influenza vaccination.
The Journal of infectious diseases 1999;179(1):31-6.
1998: Walter Emil Philipp Beyer; Iris de Bruijn; Abraham M Palache; Rudi G J Westendorp; Albert D M E Osterhaus
The plea against annual influenza vaccination? 'The Hoskins' Paradox' revisited.
Vaccine 1998;16(20):1929-32.
1998: Bas Heijmans; Rudi G J Westendorp; Dick L Knook; Cornelis Kluft; P Eline Slagboom
The risk of mortality and the factor V Leiden mutation in a population-based cohort.
Thrombosis and haemostasis 1998;80(4):607-9.
1998: Michiel W van der Linden; Tom W J Huizinga; Dirk-Jan Stoeken; Augueste Sturk; Rudi G J Westendorp
Determination of tumour necrosis factor-alpha and interleukin-10 production in a whole blood stimulation system: assessment of laboratory error and individual variation.
Journal of immunological methods 1998;218(1-2):63-71.
1998: Joyce Eskdale; Grant Gallagher; C L Verweij; Vivian Keijsers; Rudi G J Westendorp; Tom W J Huizinga
Interleukin 10 secretion in relation to human IL-10 locus haplotypes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9465-70.
1998: Gerard J Blauw; A Margot Lagaay; Rudi G J Westendorp
Statins for prevention of stroke.
Lancet 1998;352(9122):144.
1998: Louis-Jean Vleming; Johan W de Fijter; Rudi G J Westendorp; Mohamed R Daha; Jan A Bruijn; Leendert A Van Es
Histomorphometric correlates of renal failure in IgA nephropathy.
Clinical nephrology 1998;49(6):337-44.
1998: Maarten T Bastiaens; Juliette J Hoefnagel; J A Bruijn; Rudi G J Westendorp; Bert-Jan Vermeer; Jan N Bouwes Bavinck
Differences in age, site distribution, and sex between nodular and superficial basal cell carcinoma indicate different types of tumors.
The Journal of investigative dermatology 1998;110(6):880-4.
1998: Jaap T van Dissel; P van Langevelde; Rudi G J Westendorp; Kitty M C Kwappenberg; Marijke Frölich
Anti-inflammatory cytokine profile and mortality in febrile patients.
Lancet 1998;351(9107):950-3.
1997: Marjolijn Bornebroek; Rudi G J Westendorp; Joost Haan; Egbert Bakker; W F Timmers; Christine Van Broeckhoven; Raymund A C Roos
Mortality from hereditary cerebral haemorrhage with amyloidosis--Dutch type. The impact of sex, parental transmission and year of birth.
Brain : a journal of neurology 1997;120 ( Pt 12)():2243-9.
1997: Annetje Bootsma-Van Der Wiel; Rudi G J Westendorp; Dick L Knook
[Daily functioning and health care utilization among persons 85 years old and older].
Nederlands tijdschrift voor geneeskunde 1997;141(45):2170-6.
1997: Jacobijn Gussekloo; Rudi G J Westendorp; Edmond J Remarque; A Margot Lagaay; T J Heeren; Dick L Knook
Impact of mild cognitive impairment on survival in very elderly people: cohort study.
BMJ (Clinical research ed.) 1997;315(7115):1053-4.
1997: Annelies W E Weverling-Rijnsburger; Gerard J Blauw; A Margot Lagaay; Dick L Knook; A Edo Meinders; Rudi G J Westendorp
Total cholesterol and risk of mortality in the oldest old.
Lancet 1997;350(9085):1119-23.
1997: Darian P Shackleton; Rudi G J Westendorp; Dorothée G A Kasteleijn-Nolst Trenité; A de Boer; Ron Herings
Dispensing epilepsy medication: a method of determining the frequency of symptomatic individuals with seizures.
Journal of clinical epidemiology 1997;50(9):1061-8.
1997: AC Toornvliet; Hanno Pijl; Marijke Frölich; Rudi G J Westendorp; A Edo Meinders
Insulin and leptin concentrations in obese humans during long-term weight loss.
The Netherlands journal of medicine 1997;51(3):96-102.
1997: Rudi G J Westendorp; JA Langermans; Tom W J Huizinga; C L Verweij; A Sturk
Genetic influence on cytokine production in meningococcal disease.
Lancet 1997;349(9069):1912-3.
1997: AC Toornvliet; Hanno Pijl; E Hopman; Rudi G J Westendorp; A Edo Meinders
Predictors of weight loss during treatment with d-fenfluramine.
Journal of internal medicine 1997;241(5):401-6.
1997: Gerard J Blauw; A Margot Lagaay; August Smelt; Rudi G J Westendorp
Stroke, statins, and cholesterol. A meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors.
Stroke; a journal of cerebral circulation 1997;28(5):946-50.
1997: E T Hille; Rudi G J Westendorp; Jan P Vandenbroucke; FR Rosendaal
Mortality and causes of death in families with the factor V Leiden mutation (resistance to activated protein C).
Blood 1997;89(6):1963-7.
1997: Louis-Jean Vleming; J J Baelde; Rudi G J Westendorp; Mohamed R Daha; Leendert A Van Es; Jan A Bruijn
The glomerular deposition of PAS positive material correlates with renal function in human kidney diseases.
Clinical nephrology 1997;47(3):158-67.
1997: H H van Boven; Jan P Vandenbroucke; Rudi G J Westendorp; FR Rosendaal
Mortality and causes of death in inherited antithrombin deficiency.
Thrombosis and haemostasis 1997;77(3):452-5.
1997: Tom W J Huizinga; Rudi G J Westendorp; E L Bollen; Vivian Keijsers; BM Brinkman; JA Langermans; Ferdinand C Breedveld; Cornelis L Verweij; L van de Gaer; L Dams; J B A Crusius; A García-Gonzalez; Bob W van Oosten; Chris H Polman; A S Peña
TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients.
Journal of neuroimmunology 1997;72(2):149-53.
1997: Rudi G J Westendorp; JA Langermans; Tom W J Huizinga; A H Elouali; C L Verweij; dorret boomsma; Jan P Vandenbroucke; J P Vandenbrouke
Genetic influence on cytokine production and fatal meningococcal disease.
Lancet 1997;349(9046):170-3.
1996: Rudi G J Westendorp; P H Reitsma; Rogier M Bertina
Inherited prethrombotic disorders and infectious purpura.
Thrombosis and haemostasis 1996;75(6):899-901.
1996: S M Arend; Rudi G J Westendorp; Frank P Kroon; J W van't Wout; J P Vandenbroucke; L A van Es; F J van der Woude
Rejection treatment and cytomegalovirus infection as risk factors for Pneumocystis carinii pneumonia in renal transplant recipients.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1996;22(6):920-5.
1995: Louis-Jean Vleming; J J Baelde; Rudi G J Westendorp; Mohamed R Daha; Leendert A Van Es; Jan A Bruijn
Progression of chronic renal disease in humans is associated with the deposition of basement membrane components and decorin in the interstitial extracellular matrix.
Clinical nephrology 1995;44(4):211-9.
1995: Rudi G J Westendorp; Gerard J Blauw
End of New Zealand asthma epidemic.
Lancet 1995;345(8955):985.
1995: Rudi G J Westendorp; Jan A M Langermans; C E de Bel; A E Meinders; J P Vandenbroucke; R van Furth; J T van Dissel
Release of tumor necrosis factor: an innate host characteristic that may contribute to the outcome of meningococcal disease.
The Journal of infectious diseases 1995;171(4):1057-60.
1995: Gerard J Blauw; Rudi G J Westendorp
Asthma deaths in New Zealand: whodunnit?
Lancet 1995;345(8941):2-3.
1992: A J Bindels; Rudi G J Westendorp
[The spectrum of acute meningococcal disease].
Nederlands tijdschrift voor geneeskunde 1992;136(41):2001-3.