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Jukka Westerbacka

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Martin Adiels; Jan Borén; Thomas Larsson; Niina Matikainen; Sven-Olof Olofsson; Sanni Söderlund; Jukka Westerbacka; Marja-Riitta Taskinen
Postprandial accumulation of chylomicrons and chylomicron remnants is determined by the clearance capacity.
Jouni Nurmi; Jukka Westerbacka; Niko Anttalainen; James Boyd; Markku Kuisma
Early increase in blood glucose in patients resuscitated from out-of-hospital ventricular fibrillation predicts poor outcome.
Maria Kolak; Jan Liska; Matej Oresic; Scott A Summers; Jukka Westerbacka; Hannele Yki-Järvinen; Per Eriksson; Anders Franco-Cereceda; Joanna Gertow; Rachel M Fisher
Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue.

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All Publications

2012: Martin Adiels; Jan Borén; Thomas Larsson; Niina Matikainen; Sven-Olof Olofsson; Sanni Söderlund; Jukka Westerbacka; Marja-Riitta Taskinen
Postprandial accumulation of chylomicrons and chylomicron remnants is determined by the clearance capacity.
Atherosclerosis 2012;222(1):222-8.
2012: Jouni Nurmi; Jukka Westerbacka; Niko Anttalainen; James Boyd; Markku Kuisma
Early increase in blood glucose in patients resuscitated from out-of-hospital ventricular fibrillation predicts poor outcome.
Diabetes care 2012;35(3):510-2.
2012: Maria Kolak; Jan Liska; Matej Oresic; Scott A Summers; Jukka Westerbacka; Hannele Yki-Järvinen; Per Eriksson; Anders Franco-Cereceda; Joanna Gertow; Rachel M Fisher
Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue.
Lipids in health and disease 2012;11():115.
2011: Marja-Riitta Taskinen; Jukka Westerbacka; Martin Adiels; Antti Hakkarainen; Juhani Kahri; Jesper Lundbom; Nina Lundbom; Sven-Olof Olofsson; Marju Orho-Melander; Sanni Söderlund; Jan Borén
Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(9):2144-50.
2011: Jouni Nurmi; Perttu J Lindsberg; Olli Häppölä; Erkko Klemetti; Jukka Westerbacka; Maaret Castrén
Strict glucose control after acute stroke can be provided in the prehospital setting.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2011;18(4):436-9.
2011: Jesper Lundbom; Antti Hakkarainen; Sanni Söderlund; Jukka Westerbacka; Nina Lundbom; Marja-Riitta Taskinen
Long-TE 1H MRS suggests that liver fat is more saturated than subcutaneous and visceral fat.
NMR in biomedicine 2011;24(3):238-45.
2010: Jukka Westerbacka; Anna Kotronen; Barbara A Fielding; John Wahren; Leanne Hodson; Julia Perttilä; Tuulikki Seppänen-Laakso; Tapani Suortti; Johanna Arola; Rolf Hultcrantz; Sandra Castillo; Vesa M Olkkonen; Keith N Frayn; Matej Orešič; Hannele Yki-Järvinen
Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease.
Gastroenterology 2010;139(6):1961-1971.e1.
2010: Ksenia Sevastianova; Antti Hakkarainen; Anna Kotronen; Anja Cornér; Perttu Arkkila; Johanna Arola; Jukka Westerbacka; Robert Bergholm; Jesper Lundbom; Nina Lundbom; Hannele Yki-Järvinen
Nonalcoholic fatty liver disease: detection of elevated nicotinamide adenine dinucleotide phosphate with in vivo 3.0-T 31P MR spectroscopy with proton decoupling.
Radiology 2010;256(2):466-73.
2010: Jesper Lundbom; Antti Hakkarainen; Barbara Fielding; Sanni Söderlund; Jukka Westerbacka; Marja-Riitta Taskinen; Nina Lundbom
Characterizing human adipose tissue lipids by long echo time 1H-MRS in vivo at 1.5 Tesla: validation by gas chromatography.
NMR in biomedicine 2010;23(5):466-72.
2010: Anna Kotronen; Tuulikki Seppänen-Laakso; Jukka Westerbacka; Tuula Kiviluoto; Johanna Arola; Anna-Liisa Ruskeepää; Hannele Yki-Järvinen; Matej Oresic
Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serum.
Obesity (Silver Spring, Md.) 2010;18(5):937-44.
2010: Anna Aminoff; Helena Ledmyr; Petra Thulin; Kerstin Lundell; Leyla Nunez; Elisabeth Strandhagen; Charlotte Murphy; Ulf Lidberg; Jukka Westerbacka; Anders Franco-Cereceda; Jan Liska; Lars Bo Nielsen; Mats Gåfvels; Maria Nastase Mannila; Anders Hamsten; Hannele Yki-Järvinen; Dag Thelle; Per Eriksson; Jan Borén; Ewa Ehrenborg
Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease.
Journal of lipid research 2010;51(1):103-11.
2009: Vincenzo Di Marzo; An Verrijken; Antti Hakkarainen; Stefania Petrosino; Ilse Mertens; Nina Lundbom; Fabiana Piscitelli; Jukka Westerbacka; Aino Soro-Paavonen; Isabel Matias; Luc Van Gaal; Marja-Riitta Taskinen
Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects.
European journal of endocrinology / European Federation of Endocrine Societies 2009;161(5):715-22.
2009: Anna Kotronen; L E Johansson; L M Johansson; C Roos; Jukka Westerbacka; Anders Hamsten; Robert Bergholm; Perttu E T Arkkila; J Arola; Tuula Kiviluoto; Rachel M Fisher; Ewa Ehrenborg; Marju Orho-Melander; M Ridderstråle; Leif Groop; Hannele Yki-Järvinen
A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.
Diabetologia 2009;52(6):1056-60.
2009: Anna Kotronen; V R Velagapudi; L Yetukuri; Jukka Westerbacka; Robert Bergholm; K Ekroos; Janne Makkonen; Marja-Riitta Taskinen; Matej Oresic; Hannele Yki-Järvinen
Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations.
Diabetologia 2009;52(4):684-90.
2009: Anna Kotronen; Hannele Yki-Järvinen; Anna Aminoff; Robert Bergholm; Kirsi H Pietiläinen; Jukka Westerbacka; Philippa J Talmud; Steve E Humphries; Anders Hamsten; Bo Isomaa; Leif Groop; Marju Orho-Melander; Ewa Ehrenborg; Rachel M Fisher
Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts.
European journal of endocrinology / European Federation of Endocrine Societies 2009;160(4):593-602.
2009: Anna Kotronen; Tuulikki Seppänen-Laakso; Jukka Westerbacka; Tuula Kiviluoto; Johanna Arola; Anna-Liisa Ruskeepää; Matej Oresic; Hannele Yki-Järvinen
Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver.
Diabetes 2009;58(1):203-8.
2008: Dario Greco; Anna Kotronen; Jukka Westerbacka; Oscar Puig; Perttu Arkkila; Tuula Kiviluoto; Saara Laitinen; Maria Kolak; Rachel M Fisher; Anders Hamsten; Petri Auvinen; Hannele Yki-Järvinen
Gene expression in human NAFLD.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(5):G1281-7.
2008: Jukka Westerbacka; Anja Cornér; Maria Kolak; Janne Makkonen; Ursula Turpeinen; Anders Hamsten; Rachel M Fisher; Hannele Yki-Järvinen
Insulin regulation of MCP-1 in human adipose tissue of obese and lean women.
American journal of physiology. Endocrinology and metabolism 2008;294(5):E841-5.
2008: Anna Kotronen; Leena Juurinen; Antti Hakkarainen; Jukka Westerbacka; Anja Cornér; Robert Bergholm; Hannele Yki-Järvinen
Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects.
Diabetes care 2008;31(1):165-9.
2007: Martin Adiels; Jukka Westerbacka; Aino Soro-Paavonen; Anna-Maija Häkkinen; Satu Vehkavaara; Muriel J Caslake; Chris Packard; Sven-Olof Olofsson; Hannele Yki-Järvinen; Marja-Riitta Taskinen; Jan Borén
Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance.
Diabetologia 2007;50(11):2356-65.
2007: Jukka Westerbacka; Maria Kolak; Tuula Kiviluoto; Perttu Arkkila; Jukka Sirén; Anders Hamsten; Rachel M Fisher; Hannele Yki-Järvinen
Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects.
Diabetes 2007;56(11):2759-65.
2007: Janne Makkonen; Jukka Westerbacka; Maria Kolak; Jussi Sutinen; Anja Cornér; Anders Hamsten; Rachel M Fisher; Hannele Yki-Järvinen
Increased expression of the macrophage markers and of 11beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity.
International journal of obesity (2005) 2007;31(10):1617-25.
2007: Anna Kotronen; Jukka Westerbacka; Robert Bergholm; Kirsi H Pietiläinen; Hannele Yki-Järvinen
Liver fat in the metabolic syndrome.
The Journal of clinical endocrinology and metabolism 2007;92(9):3490-7.
2007: Maria Kolak; Jukka Westerbacka; Vidya R Velagapudi; Dick Wågsäter; Laxman Yetukuri; Janne Makkonen; Aila Rissanen; Anna-Maija Häkkinen; Monica Lindell; Robert Bergholm; Anders Hamsten; Per Eriksson; Rachel M Fisher; Matej Oresic; Hannele Yki-Järvinen
Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity.
Diabetes 2007;56(8):1960-8.
2007: Niina Matikainen; Sakari Mänttäri; Jukka Westerbacka; Satu Vehkavaara; Nina Lundbom; Hannele Yki-Järvinen; Marja-Riitta Taskinen
Postprandial lipemia associates with liver fat content.
The Journal of clinical endocrinology and metabolism 2007;92(8):3052-9.
2007: Marko Sysi-Aho; Aki Vehtari; Vidya R Velagapudi; Jukka Westerbacka; Laxman Yetukuri; Robert Bergholm; Marja-Riitta Taskinen; Hannele Yki-Järvinen; Matej Oresic
Exploring the lipoprotein composition using Bayesian regression on serum lipidomic profiles.
Bioinformatics (Oxford, England) 2007;23(13):i519-28.
2007: Jukka Westerbacka
PROactive in patients with type 2 diabetes and previous myocardial infarction: swinging the sword of Damocles?
Journal of the American College of Cardiology 2007;49(17):1781-2.
2007: Deborah J Wake; Magnus Strand; Eva Rask; Jukka Westerbacka; Dawn E W Livingstone; Stefan Soderberg; Ruth Andrew; Hannele Yki-Jarvinen; Tommy Olsson; Brian R Walker
Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity.
Clinical endocrinology 2007;66(3):440-6.
2007: Hannele Yki-Järvinen; Jukka Westerbacka
Insulin resistance, arterial stiffness and wave reflection.
Advances in cardiology 2007;44():252-60.
2006: Martin Adiels; Marja-Riitta Taskinen; Chris Packard; Muriel J Caslake; Aino Soro-Paavonen; Jukka Westerbacka; Satu Vehkavaara; A Häkkinen; Sven-Olof Olofsson; Hannele Yki-Järvinen; Jan Borén
Overproduction of large VLDL particles is driven by increased liver fat content in man.
Diabetologia 2006;49(4):755-65.
2006: Aino Soro-Paavonen; Jukka Westerbacka; Christian Ehnholm; Marja-Riitta Taskinen
Metabolic syndrome aggravates the increased endothelial activation and low-grade inflammation in subjects with familial low HDL.
Annals of medicine 2006;38(3):229-38.
2006: Jukka Westerbacka; Anja Cornér; Katja Kannisto; Maria Kolak; Janne Makkonen; Elena Korsheninnikova; Tuulikki Nyman; Anders Hamsten; Rachel M Fisher; Hannele Yki-Järvinen
Acute in vivo effects of insulin on gene expression in adipose tissue in insulin-resistant and insulin-sensitive subjects.
Diabetologia 2006;49(1):132-40.
2005: Jukka Westerbacka; Eeva Leinonen; Jukka T Salonen; Riitta Salonen; Anne Hiukka; Hannele Yki-Järvinen; Marja-Riitta Taskinen
Increased augmentation of central blood pressure is associated with increases in carotid intima-media thickness in type 2 diabetic patients.
Diabetologia 2005;48(8):1654-62.
2005: Martin Adiels; Jan Borén; Muriel J Caslake; Philip Stewart; Aino Soro; Jukka Westerbacka; Bernt Wennberg; Sven-Olof Olofsson; Chris Packard; Marja-Riitta Taskinen
Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(8):1697-703.
2005: Hannele Yki-Järvinen; Jukka Westerbacka
The fatty liver and insulin resistance.
Current molecular medicine 2005;5(3):287-95.
2005: Ruth Andrew; Jukka Westerbacka; John Wahren; Hannele Yki-Järvinen; Brian R Walker
The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans.
Diabetes 2005;54(5):1364-70.
2005: Jukka Westerbacka; Katriina Lammi; Anna-Maija Häkkinen; Aila Rissanen; Irma Salminen; Antti Aro; Hannele Yki-Järvinen
Dietary fat content modifies liver fat in overweight nondiabetic subjects.
The Journal of clinical endocrinology and metabolism 2005;90(5):2804-9.
2005: Kirsi H Pietiläinen; Aila Rissanen; Jaakko Kaprio; Sari Mäkimattila; Anna-Maija Häkkinen; Jukka Westerbacka; Jussi Sutinen; Satu Vehkavaara; Hannele Yki-Järvinen
Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins.
American journal of physiology. Endocrinology and metabolism 2005;288(4):E768-74.
2005: Ksenia Sevastianova; Jussi Sutinen; Jukka Westerbacka; Matti Ristola; Hannele Yki-Järvinen
Arterial stiffness in HIV-infected patients receiving highly active antiretroviral therapy.
Antiviral therapy 2005;10(8):925-35.
2005: Martin Adiels; Chris Packard; Muriel J Caslake; Philip Stewart; Aino Soro; Jukka Westerbacka; Bernt Wennberg; Sven-Olof Olofsson; Marja-Riitta Taskinen; Jan Borén
A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions.
Journal of lipid research 2005;46(1):58-67.
2004: Jukka Westerbacka; Anja Cornér; Mirja Tiikkainen; Marjo Tamminen; Satu Vehkavaara; Anna-Maija Häkkinen; J Fredriksson; Hannele Yki-Järvinen
Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk.
Diabetologia 2004;47(8):1360-9.
2004: Eeva Leinonen; Anne Hiukka; Eva Hurt-Camejo; Olov Wiklund; S S Sarna; L Mattson Hultén; Jukka Westerbacka; Riitta M Salonen; Jukka T Salonen; Marja-Riitta Taskinen
Low-grade inflammation, endothelial activation and carotid intima-media thickness in type 2 diabetes.
Journal of internal medicine 2004;256(2):119-27.
2004: Jukka Westerbacka; Robert Bergholm; Mirja Tiikkainen; Hannele Yki-Järvinen
Glargine and regular human insulin similarly acutely enhance endothelium-dependent vasodilatation in normal subjects.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(2):320-4.
2004: Jukka Westerbacka; Marjo Tamminen; J Cockcroft; Hannele Yki-Järvinen
Comparison of in vivo effects of nitroglycerin and insulin on the aortic pressure waveform.
European journal of clinical investigation 2004;34(1):1-8.
2003: Jukka Westerbacka; Hannele Yki-Järvinen; Satu Vehkavaara; Anna-Maija Häkkinen; Ruth Andrew; Deborah J Wake; Jonathan R Seckl; Brian R Walker
Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver.
The Journal of clinical endocrinology and metabolism 2003;88(10):4924-31.
2003: Marjo Tamminen; Jukka Westerbacka; Satu Vehkavaara; Hannele Yki-Järvinen
Insulin therapy improves insulin actions on glucose metabolism and aortic wave reflection in type 2 diabetic patients.
European journal of clinical investigation 2003;33(10):855-60.
2003: Marjo Tamminen; Riitta Lassila; Jukka Westerbacka; Satu Vehkavaara; Hannele Yki-Järvinen
Obesity is associated with impaired platelet-inhibitory effect of acetylsalicylic acid in nondiabetic subjects.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2003;27(8):907-11.
2003: Jussi Sutinen; Anna-Maija Häkkinen; Jukka Westerbacka; Anneli Seppälä-Lindroos; Satu Vehkavaara; Juha Halavaara; Asko Ilari Järvinen; Matti Ristola; Hannele Yki-Järvinen
Rosiglitazone in the treatment of HAART-associated lipodystrophy--a randomized double-blind placebo-controlled study.
Antiviral therapy 2003;8(3):199-207.
2003: Corradina Alagona; Aino Soro; Jukka Westerbacka; Kati Ylitalo; Jukka T Salonen; Riitta Salonen; Hannele Yki-Järvinen; Marja-Riitta Taskinen
Low HDL cholesterol concentration is associated with increased intima-media thickness independent of arterial stiffness in healthy subjects from families with low HDL cholesterol.
European journal of clinical investigation 2003;33(6):457-63.
2002: Marjo Tamminen; Jukka Westerbacka; Satu Vehkavaara; Hannele Yki-Järvinen
Insulin-induced decreases in aortic wave reflection and central systolic pressure are impaired in type 2 diabetes.
Diabetes care 2002;25(12):2314-9.
2002: Jussi Sutinen; Anna-Maija Häkkinen; Jukka Westerbacka; Anneli Seppälä-Lindroos; Satu Vehkavaara; Juha Halavaara; Asko Ilari Järvinen; Matti Ristola; Hannele Yki-Järvinen
Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy.
AIDS (London, England) 2002;16(16):2183-93.
2002: Anneli Seppälä-Lindroos; Satu Vehkavaara; Anna-Maija Häkkinen; Takashi Goto; Jukka Westerbacka; Anssi Sovijärvi; Juha Halavaara; Hannele Yki-Järvinen
Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.
The Journal of clinical endocrinology and metabolism 2002;87(7):3023-8.
2002: Jukka Westerbacka; Hannele Yki-Järvinen
Arterial stiffness and insulin resistance.
Seminars in vascular medicine 2002;2(2):157-64.
2002: Jukka Westerbacka; Hannele Yki-Järvinen; Anu M Turpeinen; Aila Rissanen; Satu Vehkavaara; Martti Syrjälä; Riitta Lassila
Inhibition of platelet-collagen interaction: an in vivo action of insulin abolished by insulin resistance in obesity.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(1):167-72.
2001: Jukka Westerbacka; Anneli Seppälä-Lindroos; Hannele Yki-Järvinen
Resistance to acute insulin induced decreases in large artery stiffness accompanies the insulin resistance syndrome.
The Journal of clinical endocrinology and metabolism 2001;86(11):5262-8.
2001: Robert Bergholm; Jukka Westerbacka; Satu Vehkavaara; Anneli Seppälä-Lindroos; Takashi Goto; Hannele Yki-Järvinen
Insulin sensitivity regulates autonomic control of heart rate variation independent of body weight in normal subjects.
The Journal of clinical endocrinology and metabolism 2001;86(3):1403-9.
2000: Satu Vehkavaara; Jukka Westerbacka; T Hakala-Ala-Pietilä; Antti Virkamäki; Outi Hovatta; Hannele Yki-Järvinen
Effect of estrogen replacement therapy on insulin sensitivity of glucose metabolism and preresistance and resistance vessel function in healthy postmenopausal women.
The Journal of clinical endocrinology and metabolism 2000;85(12):4663-70.
2000: Hannele Yki-Järvinen; Jukka Westerbacka
Vascular actions of insulin in obesity.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24 Suppl 2():S25-8.
2000: L Ryysy; Anna-Maija Häkkinen; Takashi Goto; Satu Vehkavaara; Jukka Westerbacka; Juha Halavaara; Hannele Yki-Järvinen
Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients.
Diabetes 2000;49(5):749-58.
2000: Jukka Westerbacka; A Uosukainen; Sari Mäkimattila; A Schlenzka; Hannele Yki-Järvinen
Insulin-induced decrease in large artery stiffness is impaired in uncomplicated type 1 diabetes mellitus.
Hypertension 2000;35(5):1043-8.
2000: Satu Vehkavaara; Sari Mäkimattila; A Schlenzka; Juha Vakkilainen; Jukka Westerbacka; Hannele Yki-Järvinen
Insulin therapy improves endothelial function in type 2 diabetes.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(2):545-50.
1999: Satu Vehkavaara; Anneli Seppälä-Lindroos; Jukka Westerbacka; Per-Henrik Groop; Hannele Yki-Järvinen
In vivo endothelial dysfunction characterizes patients with impaired fasting glucose.
Diabetes care 1999;22(12):2055-60.
1999: Jukka Westerbacka; I Wilkinson; J Cockcroft; T Utriainen; Satu Vehkavaara; Hannele Yki-Järvinen
Diminished wave reflection in the aorta. A novel physiological action of insulin on large blood vessels.
Hypertension 1999;33(5):1118-22.
1999: Jukka Westerbacka; Satu Vehkavaara; Robert Bergholm; I Wilkinson; J Cockcroft; Hannele Yki-Järvinen
Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity.
Diabetes 1999;48(4):821-7.