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Ole Westergaard

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Rikke From Frøhlich; Félicie Faucon Andersen; Ole Westergaard; Anni H Andersen; Birgitta R Knudsen
Regions within the N-terminal domain of human topoisomerase I exert important functions during strand rotation and DNA binding.
Félicie Faucon Andersen; Kirsten E Andersen; Mette Kusk Bøving; Rikke From Frøhlich; Ole Westergaard; Anni H Andersen; Birgitta R Knudsen
Recombinogenic flap ligation mediated by human topoisomerase I.
Félicie Faucon Andersen; Thomas Ø Tange; Thayaline Sinnathamby; Jens R Olesen; Kirsten E Andersen; Ole Westergaard; Jørgen Kjems; Birgitta R Knudsen
The RNA splicing factor ASF/SF2 inhibits human topoisomerase I mediated DNA relaxation.

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All Publications

2004: Rikke From Frøhlich; Félicie Faucon Andersen; Ole Westergaard; Anni H Andersen; Birgitta R Knudsen
Regions within the N-terminal domain of human topoisomerase I exert important functions during strand rotation and DNA binding.
Journal of molecular biology 2004;336(1):93-103.
2003: Félicie Faucon Andersen; Kirsten E Andersen; Mette Kusk Bøving; Rikke From Frøhlich; Ole Westergaard; Anni H Andersen; Birgitta R Knudsen
Recombinogenic flap ligation mediated by human topoisomerase I.
Journal of molecular biology 2003;330(2):235-46.
2002: Félicie Faucon Andersen; Thomas Ø Tange; Thayaline Sinnathamby; Jens R Olesen; Kirsten E Andersen; Ole Westergaard; Jørgen Kjems; Birgitta R Knudsen
The RNA splicing factor ASF/SF2 inhibits human topoisomerase I mediated DNA relaxation.
Journal of molecular biology 2002;322(4):677-86.
2002: Morten Christensen; Morten K Larsen; Hans U Barthelmes; Robert Hock; Claus L Andersen; Eigil Kjeldsen; Birgitta R Knudsen; Ole Westergaard; Fritz Boege; Christian Mielke
Dynamics of human DNA topoisomerases IIalpha and IIbeta in living cells.
The Journal of cell biology 2002;157(1):31-44.
2002: Christian Mielke; Morten Christensen; Ole Westergaard; Jürgen Bode; Craig J Benham; Michael Breindl
Multiple collagen I gene regulatory elements have sites of stress-induced DNA duplex destabilization and nuclear scaffold/matrix association potential.
Journal of cellular biochemistry 2002;84(3):484-96.
2001: M Lisby; J R Olesen; Camilla Skouboe; B O Krogh; Tobias Straub; Fritz Boege; Soundarapandian Velmurugan; Pia M Martensen; Anni H Andersen; Makkuni Jayaram; Ole Westergaard; Birgitta R Knudsen
Residues within the N-terminal domain of human topoisomerase I play a direct role in relaxation.
The Journal of biological chemistry 2001;276(23):20220-7.
2001: Rikke From Frøhlich; S G Hansen; M Lisby; Ian Grainge; Ole Westergaard; Makkuni Jayaram; Birgitta R Knudsen
Inhibition of Flp recombinase by the topoisomerase I-targeting drugs, camptothecin and NSC-314622.
The Journal of biological chemistry 2001;276(10):6993-7.
2001: Anni H Andersen; K Christiansen; Ole Westergaard
Uncoupling of topoisomerase-mediated DNA cleavage and religation.
Methods in molecular biology (Clifton, N.J.) 2001;95():101-17.
2000: Y Wang; A Thyssen; Ole Westergaard; Anni H Andersen
Position-specific effect of ribonucleotides on the cleavage activity of human topoisomerase II.
Nucleic acids research 2000;28(24):4815-21.
2000: Lotte Bjergbaek; PS Kingma; I S Nielsen; Y Wang; Ole Westergaard; Neil Osheroff; Anni H Andersen
Communication between the ATPase and cleavage/religation domains of human topoisomerase IIalpha.
The Journal of biological chemistry 2000;275(17):13041-8.
1999: K Christiansen; Ole Westergaard
Mapping of eukaryotic DNA topoisomerase I catalyzed cleavage without concomitant religation in the vicinity of DNA structural anomalies.
Biochimica et biophysica acta 1999;1489(2-3):249-62.
1999: Lotte Bjergbaek; S Jensen; Ole Westergaard; Anni H Andersen
Using a biochemical approach to identify the primary dimerization regions in human DNA topoisomerase IIalpha.
The Journal of biological chemistry 1999;274(37):26529-36.
1999: Y Wang; Birgitta R Knudsen; Lotte Bjergbaek; Ole Westergaard; Anni H Andersen
Stimulated activity of human topoisomerases IIalpha and IIbeta on RNA-containing substrates.
The Journal of biological chemistry 1999;274(32):22839-46.
1999: H Biersack; S Jensen; Ole Westergaard
Rapid purification of DNA topoisomerase II containing a hexahistidine tag by metal ion affinity chromatography.
Methods in molecular biology (Clifton, N.J.) 1999;94():235-41.
1998: Irina Gromova; H Biersack; S Jensen; O F Nielsen; Ole Westergaard; Anni H Andersen
Characterization of DNA topoisomerase II alpha/beta heterodimers in HeLa cells.
Biochemistry 1998;37(47):16645-52.
1998: Tobias Straub; P Grue; A Uhse; M Lisby; Birgitta R Knudsen; T O Tange; Ole Westergaard; Fritz Boege
The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction.
The Journal of biological chemistry 1998;273(41):26261-4.
1998: Birgitta R Knudsen; J Lee; M Lisby; Ole Westergaard; Makkuni Jayaram
Alcoholysis and strand joining by the Flp site-specific recombinase. Mechanistically equivalent reactions mediated by distinct catalytic configurations.
The Journal of biological chemistry 1998;273(34):22028-36.
1998: M Lisby; B O Krogh; Fritz Boege; Ole Westergaard; Birgitta R Knudsen
Camptothecins inhibit the utilization of hydrogen peroxide in the ligation step of topoisomerase I catalysis.
Biochemistry 1998;37(30):10815-27.
1997: Birgitta R Knudsen; K Dahlstrøm; Ole Westergaard; Makkuni Jayaram
The yeast site-specific recombinase Flp mediates alcoholysis and hydrolysis of the strand cleavage product: mimicking the strand-joining reaction with non-DNA nucleophiles.
Journal of molecular biology 1997;266(1):93-107.
1997: U Kellner; Hans-Juergen Heidebrecht; Pierre Rudolph; H Biersack; Friedrich Buck; T Dakowski; Hans-Heinrich Wacker; M Domanowski; A Seidel; Ole Westergaard; Reza Parwaresch
Detection of human topoisomerase II alpha in cell lines and tissues: characterization of five novel monoclonal antibodies.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1997;45(2):251-63.
1996: K Christiansen; Ole Westergaard
The effect of camptothecin on topoisomerase I catalysis.
Annals of the New York Academy of Sciences 1996;803():50-9.
1996: H Biersack; S Jensen; Irina Gromova; I S Nielsen; Ole Westergaard; Anni H Andersen
Active heterodimers are formed from human DNA topoisomerase II alpha and II beta isoforms.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8288-93.
1996: S Jensen; Anni H Andersen; E Kjeldsen; H Biersack; E H Olsen; T B Andersen; Ole Westergaard; B K Jakobsen
Analysis of functional domain organization in DNA topoisomerase II from humans and Saccharomyces cerevisiae.
Molecular and cellular biology 1996;16(7):3866-77.
1996: J Alsner; H V Sorensen; V K Schmidt; Boe Sandahl Sorensen; Ole Westergaard
Topoisomerase II-mediated DNA cleavage: evidence for distinct regions of enzyme-DNA contacts.
Journal of molecular biology 1996;259(3):317-24.
1995: Mette Kusk Bøving; Christian Bendixen; Morten Duno; Ole Westergaard; Bo Thomsen
Genetic dissection of intersubunit contacts within human protein kinase CK2.
Journal of molecular biology 1995;253(5):703-11.
1994: V K Schmidt; B S Sørensen; H V Sørensen; J Alsner; Ole Westergaard
Intramolecular and intermolecular DNA ligation mediated by topoisomerase II.
Journal of molecular biology 1994;241(1):18-25.
1994: K Christiansen; Birgitta R Knudsen; Ole Westergaard
The covalent eukaryotic topoisomerase I-DNA intermediate catalyzes pH-dependent hydrolysis and alcoholysis.
The Journal of biological chemistry 1994;269(15):11367-73.
1994: K Christiansen; Ole Westergaard
Characterization of intra- and intermolecular DNA ligation mediated by eukaryotic topoisomerase I. Role of bipartite DNA interaction in the ligation process.
The Journal of biological chemistry 1994;269(1):721-9.
1994: Anni H Andersen; J Q Svejstrup; Ole Westergaard
The DNA binding, cleavage, and religation reactions of eukaryotic topoisomerases I and II.
Advances in pharmacology (San Diego, Calif.) 1994;29A():83-101.
1993: Yuqing E Chen; N A Barlev; Ole Westergaard; B K Jakobsen
Identification of the C-terminal activator domain in yeast heat shock factor: independent control of transient and sustained transcriptional activity.
The EMBO journal 1993;12(13):5007-18.
1993: K Christiansen; A B Svejstrup; Anni H Andersen; Ole Westergaard
Eukaryotic topoisomerase I-mediated cleavage requires bipartite DNA interaction. Cleavage of DNA substrates containing strand interruptions implicates a role for topoisomerase I in illegitimate recombination.
The Journal of biological chemistry 1993;268(13):9690-701.
1993: Irina Gromova; E Kjeldsen; J Q Svejstrup; J Alsner; K Christiansen; Ole Westergaard
Characterization of an altered DNA catalysis of a camptothecin-resistant eukaryotic topoisomerase I.
Nucleic acids research 1993;21(3):593-600.
1992: E Kjeldsen; J Q Svejstrup; Irina Gromova; J Alsner; Ole Westergaard
Camptothecin inhibits both the cleavage and religation reactions of eukaryotic DNA topoisomerase I.
Journal of molecular biology 1992;228(4):1025-30.
1992: B S Sørensen; J Sinding; Anni H Andersen; J Alsner; Peter B Jensen; Ole Westergaard
Mode of action of topoisomerase II-targeting agents at a specific DNA sequence. Uncoupling the DNA binding, cleavage and religation events.
Journal of molecular biology 1992;228(3):778-86.
1992: J Alsner; J Q Svejstrup; E Kjeldsen; B S Sørensen; Ole Westergaard
Identification of an N-terminal domain of eukaryotic DNA topoisomerase I dispensable for catalytic activity but essential for in vivo function.
The Journal of biological chemistry 1992;267(18):12408-11.
1991: J Q Svejstrup; K Christiansen; Irina Gromova; Anni H Andersen; Ole Westergaard
New technique for uncoupling the cleavage and religation reactions of eukaryotic topoisomerase I. The mode of action of camptothecin at a specific recognition site.
Journal of molecular biology 1991;222(3):669-78.
1991: Bo Thomsen; Christian Bendixen; Ole Westergaard
Histone hyperacetylation is accompanied by changes in DNA topology in vivo.
European journal of biochemistry / FEBS 1991;201(1):107-11.
1991: Peter B Jensen; P S Jensen; Erland J F Demant; Ellen Friche; B S Sørensen; Maxwell Sehested; K Wassermann; Lars L Vindeløv; Ole Westergaard; Heine H Hansen
Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: relationship to DNA integrity and topoisomerase II.
Cancer research 1991;51(19):5093-9.
1991: A H Anderson; B S Sørensen; K Christiansen; J Q Svejstrup; K Lund; Ole Westergaard
Studies of the topoisomerase II-mediated cleavage and religation reactions by use of a suicidal double-stranded DNA substrate.
The Journal of biological chemistry 1991;266(14):9203-10.
1991: S Krogh; U H Mortensen; Ole Westergaard; B J Bonven
Eukaryotic topoisomerase I-DNA interaction is stabilized by helix curvature.
Nucleic acids research 1991;19(6):1235-41.
1991: Boe Sandahl Sorensen; H Fukata; P S Jensen; Anni H Andersen; K Christiansen; H Fukasawa; Ole Westergaard
Drug Stimulated DNA Cleavage Mediated by Cauliflower Topoisomerase II.
Plant physiology 1991;95(2):659-62.
1990: B S Sørensen; P S Jensen; Anni H Andersen; K Christiansen; J Alsner; Bo Thomsen; Ole Westergaard
Stimulation of topoisomerase II mediated DNA cleavage at specific sequence elements by the 2-nitroimidazole Ro 15-0216.
Biochemistry 1990;29(41):9507-15.
1990: Bo Thomsen; Christian Bendixen; K Lund; Anni H Andersen; B S Sørensen; Ole Westergaard
Characterization of the interaction between topoisomerase II and DNA by transcriptional footprinting.
Journal of molecular biology 1990;215(2):237-44.
1990: K Lund; Anni H Andersen; K Christiansen; J Q Svejstrup; Ole Westergaard
Minimal DNA requirement for topoisomerase II-mediated cleavage in vitro.
The Journal of biological chemistry 1990;265(23):13856-63.
1990: J Q Svejstrup; K Christiansen; Anni H Andersen; K Lund; Ole Westergaard
Minimal DNA duplex requirements for topoisomerase I-mediated cleavage in vitro.
The Journal of biological chemistry 1990;265(21):12529-35.
1990: Christian Bendixen; Bo Thomsen; J Alsner; Ole Westergaard
Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcription.
Biochemistry 1990;29(23):5613-9.
1990: U H Mortensen; T Stevnsner; S Krogh; Kjeld Olesen; Ole Westergaard; B J Bonven
Distamycin inhibition of topoisomerase I-DNA interaction: a mechanistic analysis.
Nucleic acids research 1990;18(8):1983-9.
1989: Anni H Andersen; K Christiansen; E L Zechiedrich; P S Jensen; Neil Osheroff; Ole Westergaard
Strand specificity of the topoisomerase II mediated double-stranded DNA cleavage reaction.
Biochemistry 1989;28(15):6237-44.
1989: E L Zechiedrich; K Christiansen; Anni H Andersen; Ole Westergaard; Neil Osheroff
Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate.
Biochemistry 1989;28(15):6229-36.
1989: T Stevnsner; U H Mortensen; Ole Westergaard; B J Bonven
Interactions between eukaryotic DNA topoisomerase I and a specific binding sequence.
The Journal of biological chemistry 1989;264(17):10110-3.
1988: E Kjeldsen; S Mollerup; Bo Thomsen; B J Bonven; Lars Bolund; Ole Westergaard
Sequence-dependent effect of camptothecin on human topoisomerase I DNA cleavage.
Journal of molecular biology 1988;202(2):333-42.
1988: C Herskind; Ole Westergaard
Variable protection by OH scavengers against radiation-induced inactivation of isolated transcriptionally active chromatin: the influence of secondary radicals.
Radiation research 1988;114(1):28-41.
1988: E Kjeldsen; B J Bonven; T Andoh; K Ishii; K Okada; Lars Bolund; Ole Westergaard
Characterization of a camptothecin-resistant human DNA topoisomerase I.
The Journal of biological chemistry 1988;263(8):3912-6.
1987: H Busk; Bo Thomsen; B J Bonven; E Kjeldsen; O F Nielsen; Ole Westergaard
Preferential relaxation of supercoiled DNA containing a hexadecameric recognition sequence for topoisomerase I.
Nature 1987;327(6123):638-40.
1987: Bo Thomsen; S Mollerup; B J Bonven; R Frank; H Blöcker; O F Nielsen; Ole Westergaard
Sequence specificity of DNA topoisomerase I in the presence and absence of camptothecin.
The EMBO journal 1987;6(6):1817-23.
1987: E Ostergaard; P Brams; Ole Westergaard; O F Nielsen
Purification and characterization of an inducible mitochondrial DNA polymerase from Tetrahymena thermophila.
Biochimica et biophysica acta 1987;908(2):150-7.
1987: K Christiansen; B J Bonven; Ole Westergaard
Mapping of sequence-specific chromatin proteins by a novel method: topoisomerase I on Tetrahymena ribosomal chromatin.
Journal of molecular biology 1987;193(3):517-25.
1985: B J Bonven; E Gocke; Ole Westergaard
A high affinity topoisomerase I binding sequence is clustered at DNAase I hypersensitive sites in Tetrahymena R-chromatin.
Cell 1985;41(2):541-51.
1985: Anni H Andersen; E Gocke; B J Bonven; O F Nielsen; Ole Westergaard
Topoisomerase I has a strong binding preference for a conserved hexadecameric sequence in the promoter region of the rRNA gene from Tetrahymena pyriformis.
Nucleic acids research 1985;13(5):1543-57.
1984: O F Nielsen; M Carin; Ole Westergaard
Studies on transcription termination and splicing of the rRNA precursor in vivo in the presence of proflavine.
Nucleic acids research 1984;12(2):873-86.
1983: E Gocke; B J Bonven; Ole Westergaard
A site and strand specific nuclease activity with analogies to topoisomerase I frames the rRNA gene of Tetrahymena.
Nucleic acids research 1983;11(22):7661-78.
1982: B Bonven; Ole Westergaard
DNase I hypersensitive regions correlate with a site-specific endogenous nuclease activity on the r-chromatin of Tetrahymena.
Nucleic acids research 1982;10(23):7593-608.
1981: S Borchsenius; B Bonven; J C Leer; Ole Westergaard
Nuclease-sensitive regions on the extrachromosomal r-chromatin from Tetrahymena pyriformis.
European journal of biochemistry / FEBS 1981;117(2):245-50.
1980: M Carin; B F Jensen; K D Jentsch; J C Leer; O F Nielsen; Ole Westergaard
In vitro splicing of the ribosomal RNA precursor in isolated nucleoli from Tetrahymena.
Nucleic acids research 1980;8(23):5551-66.