FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Hans Westerhoff

Research Profile

Concepts & Ideas

Occupations

Physiology

Living Beings

Chemicals & Drugs

Activities & Behaviors

Computer Simulation

Co-author Network

Publications

TOP 3
Malkhey Verma; Hans V Westerhoff; Richard J Byers; Ehsan Ghayoor Karimiani; Samrina Rehman; Philip J R Day
Mathematical modelling of miRNA mediated BCR.ABL protein regulation in chronic myeloid leukaemia vis-a-vis therapeutic strategies.
Alexey Kolodkin; Anna Phillips; Frank J Bruggeman; Steve R Hood; Nilgun Sahin; Hans V Westerhoff; Nick Plant
Optimization of stress response through the nuclear receptor-mediated cortisol signalling network.
Mark J Quinton-Tulloch; Jacky L Snoep; Frank J Bruggeman; Hans V Westerhoff
Trade-off of dynamic fragility but not of robustness in metabolic pathways in silico.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Hans Westerhoff (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Malkhey Verma; Hans V Westerhoff; Richard J Byers; Ehsan Ghayoor Karimiani; Samrina Rehman; Philip J R Day
Mathematical modelling of miRNA mediated BCR.ABL protein regulation in chronic myeloid leukaemia vis-a-vis therapeutic strategies.
Integrative biology : quantitative biosciences from nano to macro 2013;5(3):543-54.
2013: Alexey Kolodkin; Anna Phillips; Frank J Bruggeman; Steve R Hood; Nilgun Sahin; Hans V Westerhoff; Nick Plant
Optimization of stress response through the nuclear receptor-mediated cortisol signalling network.
Nature communications 2013;4():1792.
2013: Mark J Quinton-Tulloch; Jacky L Snoep; Frank J Bruggeman; Hans V Westerhoff
Trade-off of dynamic fragility but not of robustness in metabolic pathways in silico.
The FEBS journal 2013;280(1):160-73.
2013: Malkhey Verma; Matthias Reuss; Maksim Zakhartsev; Hans V Westerhoff
'Domino' systems biology and the 'A' of ATP.
Biochimica et biophysica acta 2013;1827(1):19-29.
2012: Rodolfo García-Contreras; Paul Vos; Hans V Westerhoff; Fred C Boogerd
Why in vivo may not equal in vitro - new effectors revealed by measurement of enzymatic activities under the same in vivo-like assay conditions.
The FEBS journal 2012;279(22):4145-59.
2012: Samrina Rehman; Hans V Westerhoff; Yun Xu; Philip J R Day; Warwick B Dunn; Royston Goodacre; Ardeshir Bayat
Dupuytren's disease metabolite analyses reveals alterations following initial short-term fibroblast culturing.
Molecular bioSystems 2012;8(9):2274-88.
2012: Suzanne Geenen; J Gerry Kenna; Jacky L Snoep; Peter Neal Taylor; Ian D Wilson; Hans V Westerhoff
Systems biology tools for toxicology.
Archives of toxicology 2012;86(8):1251-71.
2012: Suzanne Geenen; Michael Reed; Franco B du Preez; Hans V Westerhoff; Ian D Wilson; J Gerry Kenna; H Frederik Nijhout; Jacky L Snoep
A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012;46(4):233-43.
2012: Alexey Kolodkin; Jeantine Lunshof; Rafael Moreno-Sanchez; Nick Plant; Jacky L Snoep; Barbara M Bakker; Rudi Balling; Fred C Boogerd; Frank J Bruggeman; Valeri Goncharuk; Nilgun Yilmaz; Hans V Westerhoff
Emergence of the silicon human and network targeting drugs.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012;46(4):190-7.
2012: Malgorzata Adamczyk; Hans V Westerhoff
Engineering of self-sustaining systems: substituting the yeast glucose transporter plus hexokinase for the Lactococcus lactis phosphotransferase system in a Lactococcus lactis network in silico.
Biotechnology journal 2012;7(7):877-83.
2012: Justyna Jozefczuk; Karl Kashofer; Ulrike Korf; Hans Lehrach; Christian Regenbrecht; Samrina Rehman; Paola Turano; Ramesh Ummanni; Hans V Westerhoff; Christoph Wierling; Wasco Wruck; Kurt Zatloukal; Ivano Bertini; Andriani Daskalaki; Suzanne Geenen; Frauke Henjes; Christian Regenbrecht
A Systems Biology Approach to Deciphering the Etiology of Steatosis Employing Patient-Derived Dermal Fibroblasts and iPS Cells.
Frontiers in physiology 2012;3():339.
2012: Samrina Rehman; Ardeshir Bayat; Philip J R Day; Hans V Westerhoff
Understanding Dupuytren's Disease Using Systems Biology: A Move Away from Reductionism.
Frontiers in physiology 2012;3():316.
2012: Alexey Kolodkin; Evangelos Simeonidis; Rudi Balling; Hans V Westerhoff
Understanding complexity in neurodegenerative diseases: in silico reconstruction of emergence.
Frontiers in physiology 2012;3():291.
2012: Karen van Eunen; Hans V Westerhoff; José A L Kiewiet; Barbara M Bakker
Testing biochemistry revisited: how in vivo metabolism can be understood from in vitro enzyme kinetics.
PLoS computational biology 2012;8(4):e1002483.
2011: Christopher A Sellick; Gill Stephens; Hans V Westerhoff; Alexandra S Croxford; Royston Goodacre; Arfa R Maqsood; Alan J Dickson
Metabolite profiling of recombinant CHO cells: designing tailored feeding regimes that enhance recombinant antibody production.
Biotechnology and bioengineering 2011;108(12):3025-31.
2011: Suzanne Geenen; Cristina Guallar-Hoyas; J Gerry Kenna; Kyle L Kolaja; Filippos Michopoulos; Paul Thomas; Hans V Westerhoff; Ian D Wilson
HPLC-MS/MS methods for the quantitative analysis of 5-oxoproline (pyroglutamate) in rat plasma and hepatic cell line culture medium.
Journal of pharmaceutical and biomedical analysis 2011;56(3):655-63.
2011: Ettore Murabito; Kieran Smallbone; Jonathan Swinton; Hans V Westerhoff; Ralf Steuer
A probabilistic approach to identify putative drug targets in biochemical networks.
Journal of the Royal Society, Interface / the Royal Society 2011;8(59):880-95.
2011: Robert A Alberty; Athel Cornish-Bowden; Robert N Goldberg; Gordon G Hammes; Keith Tipton; Hans V Westerhoff
Recommendations for terminology and databases for biochemical thermodynamics.
Biophysical chemistry 2011;155(2-3):89-103.
2011: Suzanne Geenen; Filippos Michopoulos; J Gerry Kenna; Kyle L Kolaja; Hans V Westerhoff; Ian Wilson
HPLC-MS/MS methods for the quantitative analysis of ophthalmic acid in rodent plasma and hepatic cell line culture medium.
Journal of pharmaceutical and biomedical analysis 2011;54(5):1128-35.
2011: Lidia Becla; Jeantine E Lunshof; David Gurwitz; Tobias Schulte In den Bäumen; Hans V Westerhoff; Bodo M H Lange; Angela Brand
Health technology assessment in the era of personalized health care.
International journal of technology assessment in health care 2011;27(2):118-26.
2011: Maciej Swat; Mark Quinton Tulloch; Arthur J Verhoeven; Frank J Bruggeman; Szymon M Kiełbasa; Brett Olivier; Sebastian Polak; Jacky L Snoep; Hans V Westerhoff
What it takes to understand and cure a living system: computational systems biology and a systems biology-driven pharmacokinetics-pharmacodynamics platform.
Interface focus 2011;1(1):16-23.
2011: Fred C Boogerd; Hongwu Ma; Frank J Bruggeman; Wally C van Heeswijk; Rodolfo García-Contreras; Douwe Molenaar; Klaas Krab; Hans V Westerhoff
AmtB-mediated NH3 transport in prokaryotes must be active and as a consequence regulation of transport by GlnK is mandatory to limit futile cycling of NH4(+)/NH3.
FEBS letters 2011;585(1):23-8.
2011: Daniel Jameson; Malkhey Verma; Hans V Westerhoff
Methods in systems biology. Preface.
Methods in enzymology 2011;500():xxiii-xxiv.
2011: Karen van Eunen; Hans V Westerhoff; Jildau Bouwman; Sergio Rossell; Barbara M Bakker
Quantitative analysis of flux regulation through hierarchical regulation analysis.
Methods in enzymology 2011;500():571-95.
2011: Malgorzata Adamczyk; Barbara M Bakker; Karen van Eunen; Hans V Westerhoff
Enzyme kinetics for systems biology when, why and how.
Methods in enzymology 2011;500():233-57.
2011: Sanjay M Nilapwar; Maria Nardelli; Hans V Westerhoff; Malkhey Verma
Absorption spectroscopy.
Methods in enzymology 2011;500():59-75.
2011: Hans V Westerhoff
Systems biology left and right.
Methods in enzymology 2011;500():3-11.
2011: Samrina Rehman; Ardeshir Bayat; Philip J Day; Royston Goodacre; Hans V Westerhoff
Dupuytren's: a systems biology disease.
Arthritis research & therapy 2011;13(5):238.
2011: Jurgen Haanstra; Eduard J Kerkhoven; Arjen van Tuijl; Marjolein Blits; Martin Wurst; Rick van Nuland; Marie-Astrid Albert; Paul A M Michels; Jildau Bouwman; Christine Clayton; Hans V Westerhoff; Barbara M Bakker
A domino effect in drug action: from metabolic assault towards parasite differentiation.
Molecular microbiology 2011;79(1):94-108.
2010: Alexey N Kolodkin; Frank J Bruggeman; Nick Plant; Martijn J Moné; Barbara M Bakker; Moray J Campbell; Johannes P T M van Leeuwen; Carsten Carlberg; Jacky L Snoep; Hans V Westerhoff
Design principles of nuclear receptor signaling: how complex networking improves signal transduction.
Molecular systems biology 2010;6():446.
2010: Rafael Moreno-Sanchez; Emma Saavedra; Sara Rodríguez-Enríquez; Juan Carlos Gallardo-Pérez; Héctor Quezada; Hans V Westerhoff
Metabolic control analysis indicates a change of strategy in the treatment of cancer.
Mitochondrion 2010;10(6):626-39.
2010: Evangelos Simeonidis; Ettore Murabito; Kieran Smallbone; Hans V Westerhoff
Why does yeast ferment? A flux balance analysis study.
Biochemical Society transactions 2010;38(5):1225-9.
2010: Hans V Westerhoff; Malkhey Verma; Maria Nardelli; Malgorzata Adamczyk; Karen van Eunen; Evangelos Simeonidis; Barbara M Bakker
Systems biochemistry in practice: experimenting with modelling and understanding, with regulation and control.
Biochemical Society transactions 2010;38(5):1189-96.
2010: Bas Teusink; Hans V Westerhoff; Frank J Bruggeman
Comparative systems biology: from bacteria to man.
Wiley interdisciplinary reviews. Systems biology and medicine 2010;2(5):518-32.
2010: Barbara M Bakker; R Luise Krauth-Siegel; Christine Clayton; Keith Matthews; Mark Girolami; Hans V Westerhoff; Paul A M Michels; Rainer Breitling; Michael P Barrett
The silicon trypanosome.
Parasitology 2010;137(9):1333-41.
2010: K van Eunen; P Dool; A B Canelas; J Kiewiet; Jildau Bouwman; W M van Gulik; Hans V Westerhoff; B M Bakker
Time-dependent regulation of yeast glycolysis upon nitrogen starvation depends on cell history.
IET systems biology 2010;4(2):157-68.
2010: Karen van Eunen; Jildau Bouwman; Pascale Daran-Lapujade; Jarne Postmus; André B Canelas; Femke I C Mensonides; Rick Orij; Isil Tuzun; Joost van den Brink; Gertien Smits; Walter M van Gulik; Stanley Brul; Joseph J Heijnen; Johannes H De Winde; M Joost Teixeira de Mattos; Carsten Kettner; Jens Nielsen; Hans V Westerhoff; Barbara M Bakker
Measuring enzyme activities under standardized in vivo-like conditions for systems biology.
The FEBS journal 2010;277(3):749-60.
2010: Peter Li; Joseph O Dada; Daniel Jameson; Irena Spasic; Neil Swainston; Kathleen Carroll; Warwick Dunn; Farid Khan; Naglis Malys; Hanan Messiha; Evangelos Simeonidis; Dieter Weichart; Catherine L Winder; Jill Wishart; David S Broomhead; Carole Goble; Simon J Gaskell; Douglas B Kell; Hans V Westerhoff; Pedro Mendes; Norman W Paton
Systematic integration of experimental data and models in systems biology.
BMC bioinformatics 2010;11():582.
2010: Riaan Conradie; Frank J Bruggeman; Andrea Ciliberto; Attila Csikàsz-Nagy; Bela Novák; Hans V Westerhoff; Jacky L Snoep
Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex.
The FEBS journal 2010;277(2):357-67.
2009: Hans V Westerhoff; Catherine Winder; Hanan Messiha; Evangelos Simeonidis; Malgorzata Adamczyk; Malkhey Verma; Frank J Bruggeman; Warwick Dunn
Systems biology: the elements and principles of life.
FEBS letters 2009;583(24):3882-90.
2009: Hanna M Härdin; Antonios Zagaris; Klaas Krab; Hans V Westerhoff
Simplified yet highly accurate enzyme kinetics for cases of low substrate concentrations.
The FEBS journal 2009;276(19):5491-506.
2009: Karen van Eunen; Jildau Bouwman; Alexander Lindenbergh; Hans V Westerhoff; Barbara M Bakker
Time-dependent regulation analysis dissects shifts between metabolic and gene-expression regulation during nitrogen starvation in baker's yeast.
The FEBS journal 2009;276(19):5521-36.
2009: Frank J Bruggeman; Nils Blüthgen; Hans V Westerhoff
Noise management by molecular networks.
PLoS computational biology 2009;5(9):e1000506.
2009: Bin Lin; Hans V Westerhoff; Wilfred F M Röling
How Geobacteraceae may dominate subsurface biodegradation: physiology of Geobacter metallireducens in slow-growth habitat-simulating retentostats.
Environmental microbiology 2009;11(9):2425-33.
2009: Hans V Westerhoff; Douglas B Kelt
Matrix method for determining steps most rate-limiting to metabolic fluxes in biotechnological processes. 1987.
Biotechnology and bioengineering 2009;104(1):1-9.
2009: Tatjana Degenhardt; Katja N Rybakova; Aleksandra Tomaszewska; Martijn J Moné; Hans V Westerhoff; Frank J Bruggeman; Carsten Carlberg
Population-level transcription cycles derive from stochastic timing of single-cell transcription.
Cell 2009;138(3):489-501.
2009: Wally C van Heeswijk; Douwe Molenaar; Sjouke Hoving; Hans V Westerhoff
The pivotal regulator GlnB of Escherichia coli is engaged in subtle and context-dependent control.
The FEBS journal 2009;276(12):3324-40.
2009: Sonja-Verena Albers; Nils-Kåre Birkeland; Arnold J M Driessen; Susanne Gertig; Patrick Haferkamp; Hans-Peter Klenk; Theresa Kouril; Andrea Manica; Trong Khoa Pham; Peter Ruoff; Christa Schleper; Dietmar Schomburg; Kieran J Sharkey; Bettina Siebers; Pawel Sierocinski; Ralf Steuer; John van der Oost; Hans V Westerhoff; Patricia Wieloch; Phillip C Wright; Melanie Zaparty
SulfoSYS (Sulfolobus Systems Biology): towards a silicon cell model for the central carbohydrate metabolism of the archaeon Sulfolobus solfataricus under temperature variation.
Biochemical Society transactions 2009;37(Pt 1):58-64.
2009: Kim Monkhorst; Bas de Hoon; Iris Jonkers; Eskeatnaf Mulugeta Achame; Wouter Monkhorst; Jos W Hoogerbrugge; Eveline Rentmeester; Hans V Westerhoff; Frank Grosveld; J Anton Grootegoed; Joost Gribnau
The probability to initiate X chromosome inactivation is determined by the X to autosomal ratio and X chromosome specific allelic properties.
PloS one 2009;4(5):e5616.
2009: Hans V Westerhoff; Alexey Kolodkin; Riaan Conradie; Stephen J Wilkinson; Frank J Bruggeman; Klaas Krab; Jan H van Schuppen; Hanna Hardin; Barbara M Bakker; Martijn J Moné; Katja N Rybakova; Marco Eijken; Hans J P van Leeuwen; Jacky L Snoep
Systems biology towards life in silico: mathematics of the control of living cells.
Journal of mathematical biology 2009;58(1-2):7-34.
2008: Jurgen Haanstra; Arjen van Tuijl; Peter Kessler; Willem Reijnders; Paul A M Michels; Hans V Westerhoff; Marilyn Parsons; Barbara M Bakker
Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(46):17718-23.
2008: Frank J Bruggeman; Jacky L Snoep; Hans V Westerhoff
Control, responses and modularity of cellular regulatory networks: a control analysis perspective.
IET systems biology 2008;2(6):397-410.
2008: Judit Oláh; Péter Klivényi; Gabriella Gardián; László Vécsei; Ferenc Orosz; Gabor Geza Kovacs; Hans V Westerhoff; Judit Ovádi
Increased glucose metabolism and ATP level in brain tissue of Huntington's disease transgenic mice.
The FEBS journal 2008;275(19):4740-55.
2008: Hans V Westerhoff; Erik Mosekilde; Christian R Noe; Anne Marie Clemensen
Integrating systems approaches into pharmaceutical sciences.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;35(1-2):1-4.
2008: Hans V Westerhoff
Signalling control strength.
Journal of theoretical biology 2008;252(3):555-67.
2008: C M Jonker; Jacky L Snoep; J Treur; Hans V Westerhoff; W C A Wijngaards
BDI-modelling of complex intracellular dynamics.
Journal of theoretical biology 2008;251(1):1-23.
2008: Jurgen Haanstra; Mhairi Stewart; Van-Duc Luu; Arjen van Tuijl; Hans V Westerhoff; Christine Clayton; Barbara M Bakker
Control and regulation of gene expression: quantitative analysis of the expression of phosphoglycerate kinase in bloodstream form Trypanosoma brucei.
The Journal of biological chemistry 2008;283(5):2495-507.
2008: Sergio Rossell; Alexander Lindenbergh; Coen C van der Weijden; Arthur L Kruckeberg; Karen van Eunen; Hans V Westerhoff; Barbara M Bakker
Mixed and diverse metabolic and gene-expression regulation of the glycolytic and fermentative pathways in response to a HXK2 deletion in Saccharomyces cerevisiae.
FEMS yeast research 2008;8(1):155-64.
2008: Annamaria Bevilacqua; Stephen J Wilkinson; Richard Dimelow; Ettore Murabito; Samrina Rehman; Maria Nardelli; Karen van Eunen; Sergio Rossell; Frank J Bruggeman; Nils Blüthgen; Dirk De Vos; Jildau Bouwman; Barbara M Bakker; Hans V Westerhoff
Vertical systems biology: from DNA to flux and back.
SEB experimental biology series 2008;61():65-91.
2008: Stefan Legewie; Hanspeter Herzel; Hans V Westerhoff; Nils Blüthgen
Recurrent design patterns in the feedback regulation of the mammalian signalling network.
Molecular systems biology 2008;4():190.
2007: Pascale Daran-Lapujade; Sergio Rossell; Walter M van Gulik; Marijke A H Luttik; Marco J L de Groot; Monique Slijper; albert heck; Jean-Marc Daran; Johannes H De Winde; Hans V Westerhoff; Jack T. Pronk; Barbara M Bakker
The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(40):15753-8.
2007: Jolita Ciapaite; Stephan J L Bakker; Gerco Van Eikenhorst; Marijke J Wagner; Tom Teerlink; Casper G Schalkwijk; Mariann Fodor; D Margriet Ouwens; Michaela Diamant; Robert J Heine; Hans V Westerhoff; Klaas Krab
Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats.
Biochimica et biophysica acta 2007;1772(3):307-16.
2007: Jolita Ciapaite; Jan van Bezu; Gerco Van Eikenhorst; Stephan J L Bakker; Tom Teerlink; Michaela Diamant; Robert J Heine; Klaas Krab; Hans V Westerhoff; Casper G Schalkwijk
Palmitate and oleate have distinct effects on the inflammatory phenotype of human endothelial cells.
Biochimica et biophysica acta 2007;1771(2):147-54.
2007: Peter Ruoff; Maksim Zakhartsev; Hans V Westerhoff
Temperature compensation through systems biology.
The FEBS journal 2007;274(4):940-50.
2007: Wilfred F M Röling; Boris M van Breukelen; Frank J Bruggeman; Hans V Westerhoff
Ecological control analysis: being(s) in control of mass flux and metabolite concentrations in anaerobic degradation processes.
Environmental microbiology 2007;9(2):500-11.
2007: Frank J Bruggeman; Sergio Rossell; Karen Van Eunen; Jildau Bouwman; Hans V Westerhoff; Barbara M Bakker
Systems biology and the reconstruction of the cell: from molecular components to integral function.
Sub-cellular biochemistry 2007;43():239-62.
2007: Frank J Bruggeman; Jorrit J Hornberg; Fred C Boogerd; Hans V Westerhoff
Introduction to systems biology.
EXS 2007;97():1-19.
2007: Hans V Westerhoff
Systems biology: new paradigms for cell biology and drug design.
Ernst Schering Research Foundation workshop 2007;(61):45-67.
2007: Jorrit J Hornberg; Frank J Bruggeman; Barbara M Bakker; Hans V Westerhoff
Metabolic control analysis to identify optimal drug targets.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 2007;64():171, 173-89.
2007: Frank J Bruggeman; Hans V Westerhoff
The nature of systems biology.
Trends in microbiology 2007;15(1):45-50.
2007: Hans V Westerhoff
Mathematical and theoretical biology for systems biology, and then ... vice versa.
Journal of mathematical biology 2007;54(1):147-50.
2006: Jolita Ciapaite; Stephan J L Bakker; Michaela Diamant; Gerco Van Eikenhorst; Robert J Heine; Hans V Westerhoff; Klaas Krab
Metabolic control of mitochondrial properties by adenine nucleotide translocator determines palmitoyl-CoA effects. Implications for a mechanism linking obesity and type 2 diabetes.
The FEBS journal 2006;273(23):5288-302.
2006: Frank J Bruggeman; Hans V Westerhoff
Approaches to biosimulation of cellular processes.
Journal of biological physics 2006;32(3-4):273-88.
2006: Jorrit J Hornberg; Hans V Westerhoff
Oncogenes are to lose control on signaling following mutation: should we aim off target?
Molecular biotechnology 2006;34(2):109-16.
2006: Jorrit J Hornberg; Henk Dekker; Peter H J Peters; Petra Langerak; Hans V Westerhoff; Jan Lankelma; Everardus J J van Zoelen
Epidermal growth factor receptor-induced activator protein 1 activity controls density-dependent growth inhibition in normal rat kidney fibroblasts.
Molecular biotechnology 2006;34(2):101-8.
2006: Nathan R Brady; Anne Hamacher-Brady; Hans V Westerhoff; Roberta Anne Gottlieb
A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria.
Antioxidants & redox signaling 2006;8(9-10):1651-65.
2006: Jacky L Snoep; Hans V Westerhoff; Johann M Rohwer; J H S Hofmeyr
Is there an optimal ribosome concentration for maximal protein production?
Systems biology 2006;153(5):398-400.
2006: Frank J Bruggeman; Jurriaan de Haan; H Hardin; Jildau Bouwman; Sergio Rossell; K van Eunen; Barbara M Bakker; Hans V Westerhoff
Time-dependent hierarchical regulation analysis: deciphering cellular adaptation.
Systems biology 2006;153(5):318-22.
2006: Riaan Conradie; Hans V Westerhoff; Johann M Rohwer; J H S Hofmeyr; Jacky L Snoep
Summation theorems for flux and concentration control coefficients of dynamic systems.
Systems biology 2006;153(5):314-7.
2006: Nils Blüthgen; Frank J Bruggeman; Stefan Legewie; Hanspeter Herzel; Hans V Westerhoff; Boris N Kholodenko
Effects of sequestration on signal transduction cascades.
The FEBS journal 2006;273(5):895-906.
2006: Marina Rautenbach; Gertrude D Gerstner; N Marè Vlok; Janine Kulenkampff; Hans V Westerhoff
Analyses of dose-response curves to compare the antimicrobial activity of model cationic alpha-helical peptides highlights the necessity for a minimum of two activity parameters.
Analytical biochemistry 2006;350(1):81-90.
2006: Sergio Rossell; Coen C van der Weijden; Alexander Lindenbergh; Arjen van Tuijl; Christof Francke; Barbara M Bakker; Hans V Westerhoff
Unraveling the complexity of flux regulation: a new method demonstrated for nutrient starvation in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2166-71.
2006: Jorrit J Hornberg; Frank J Bruggeman; Hans V Westerhoff; Jan Lankelma
Cancer: a Systems Biology disease.
Bio Systems 2006;83(2-3):81-90.
2006: Jacky L Snoep; Frank Bruggeman; Brett Olivier; Hans V Westerhoff
Towards building the silicon cell: a modular approach.
Bio Systems 2006;83(2-3):207-16.
2005: Bin Lin; Martin Braster; Boris M van Breukelen; Henk W van Verseveld; Hans V Westerhoff; Wilfred F M Röling
Geobacteraceae community composition is related to hydrochemistry and biodegradation in an iron-reducing aquifer polluted by a neighboring landfill.
Applied and environmental microbiology 2005;71(10):5983-91.
2005: Hubertus J E Beaumont; Sylvia I Lens; Hans V Westerhoff; Rob J M van Spanning
Novel nirK cluster genes in Nitrosomonas europaea are required for NirK-dependent tolerance to nitrite.
Journal of bacteriology 2005;187(19):6849-51.
2005: Jorrit J Hornberg; Bernd Binder; Frank J Bruggeman; Birgit Schoeberl; Reinhart Heinrich; Hans V Westerhoff
Control of MAPK signalling: from complexity to what really matters.
Oncogene 2005;24(36):5533-42.
2005: Yoshiyuki Sakaki; Boris N Kholodenko; Mariko Hatakeyama; Hiroaki Kitano; Walter Kolch; Pierre De Meyts; Yosef Yarden; Hans V Westerhoff; H Steven Wiley
The International Consortium on Systems Biology of Receptor Tyrosine Kinase Regulatory Networks.
Systems biology 2005;152(2):53-4.
2005: Frank J Bruggeman; Fred C Boogerd; Hans V Westerhoff
The multifarious short-term regulation of ammonium assimilation of Escherichia coli: dissection using an in silico replica.
The FEBS journal 2005;272(8):1965-85.
2005: Karin A Reijenga; Barbara M Bakker; Coen C van der Weijden; Hans V Westerhoff
Training of yeast cell dynamics.
The FEBS journal 2005;272(7):1616-24.
2005: Jolita Ciapaite; Gerco Van Eikenhorst; Stephan J L Bakker; Michaela Diamant; Robert J Heine; Marijke J Wagner; Hans V Westerhoff; Klaas Krab
Modular kinetic analysis of the adenine nucleotide translocator-mediated effects of palmitoyl-CoA on the oxidative phosphorylation in isolated rat liver mitochondria.
Diabetes 2005;54(4):944-51.
2005: Sergio Rossell; Coen C van der Weijden; Arthur L Kruckeberg; Barbara M Bakker; Hans V Westerhoff
Hierarchical and metabolic regulation of glucose influx in starved Saccharomyces cerevisiae.
FEMS yeast research 2005;5(6-7):611-9.
2005: Karin A Reijenga; Yvonne M G A van Megen; Bob W Kooi; Barbara M Bakker; Jacky L Snoep; Henk W van Verseveld; Hans V Westerhoff
Yeast glycolytic oscillations that are not controlled by a single oscillophore: a new definition of oscillophore strength.
Journal of theoretical biology 2005;232(3):385-98.
2005: Jorrit J Hornberg; Frank J Bruggeman; Bernd Binder; Christian R Geest; A J Marjolein Bij de Vaate; Jan Lankelma; Reinhart Heinrich; Hans V Westerhoff
Principles behind the multifarious control of signal transduction. ERK phosphorylation and kinase/phosphatase control.
The FEBS journal 2005;272(1):244-58.
2004: Hans V Westerhoff; Bernhard O Palsson
The evolution of molecular biology into systems biology.
Nature biotechnology 2004;22(10):1249-52.
2004: Hubertus J E Beaumont; Sylvia I Lens; Willem N M Reijnders; Hans V Westerhoff; Rob J M van Spanning
Expression of nitrite reductase in Nitrosomonas europaea involves NsrR, a novel nitrite-sensitive transcription repressor.
Molecular microbiology 2004;54(1):148-58.
2004: Boris N Goldstein; Gennady Ermakov; Josep J Centelles; Hans V Westerhoff; Marta Cascante
What makes biochemical networks tick?
European journal of biochemistry / FEBS 2004;271(19):3877-87.
2004: Nathan R Brady; Steven P Elmore; Johannes J H G M van Beek; Klaas Krab; Pierre J Courtoy; Louis Hue; Hans V Westerhoff
Coordinated behavior of mitochondria in both space and time: a reactive oxygen species-activated wave of mitochondrial depolarization.
Biophysical journal 2004;87(3):2022-34.
2004: Hubertus J E Beaumont; Bas van Schooten; Sylvia I Lens; Hans V Westerhoff; Rob J M van Spanning
Nitrosomonas europaea expresses a nitric oxide reductase during nitrification.
Journal of bacteriology 2004;186(13):4417-21.
2004: James O Lloyd-Smith; Wayne M Getz; Hans V Westerhoff
Frequency-dependent incidence in models of sexually transmitted diseases: portrayal of pair-based transmission and effects of illness on contact behaviour.
Proceedings. Biological sciences / The Royal Society 2004;271(1539):625-34.
2003: Mark A Peletier; Hans V Westerhoff; Boris N Kholodenko
Control of spatially heterogeneous and time-varying cellular reaction networks: a new summation law.
Journal of theoretical biology 2003;225(4):477-87.
2003: Christof Francke; Pieter W Postma; Hans V Westerhoff; Joke G Blom; Mark A Peletier
Why the phosphotransferase system of Escherichia coli escapes diffusion limitation.
Biophysical journal 2003;85(1):612-22.
2003: Hans V Westerhoff; Frank Bruggeman; Jan-Hendrik S Hofmeyr; Jacky L Snoep
Attractive models: how to make the silicon cell relevant and dynamic.
Comparative and functional genomics 2003;4(1):155-8.
2002: Frank J Bruggeman; Hans V Westerhoff; Jan B Hoek; Boris N Kholodenko
Modular response analysis of cellular regulatory networks.
Journal of theoretical biology 2002;218(4):507-20.
2002: Oscar J G Somsen; Marco Siderius; Florian F Bauer; Jacky L Snoep; Hans V Westerhoff
Selectivity in overlapping MAP kinase cascades.
Journal of theoretical biology 2002;218(3):343-54.
2002: Boris N Kholodenko; Anatoly Kiyatkin; Frank J Bruggeman; Eduardo Sontag; Hans V Westerhoff; Jan B Hoek
Untangling the wires: a strategy to trace functional interactions in signaling and gene networks.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12841-6.
2002: Sarah Koefoed; Marijke Otten; Brian J Koebmann; Frank J Bruggeman; Barbara M Bakker; Jacky L Snoep; Klaas Krab; Rob J M van Spanning; Henk van Verseveld; Peter Jensen; Johanna Koster; Hans V Westerhoff
A turbo engine with automatic transmission? How to marry chemicomotion to the subtleties and robustness of life.
Biochimica et biophysica acta 2002;1555(1-3):75-82.
2002: Alberto de la Fuente; Jacky L Snoep; Hans V Westerhoff; Pedro Mendes
Metabolic control in integrated biochemical systems.
European journal of biochemistry / FEBS 2002;269(18):4399-408.
2002: Brian J Koebmann; Hans V Westerhoff; Jacky L Snoep; Dan Nilsson; Peter R Jensen
The glycolytic flux in Escherichia coli is controlled by the demand for ATP.
Journal of bacteriology 2002;184(14):3909-16.
2002: Hubertus J E Beaumont; Norman G Hommes; Luis A Sayavedra-Soto; Daniel J Arp; David M Arciero; Alan B Hooper; Hans V Westerhoff; Rob J M van Spanning
Nitrite reductase of Nitrosomonas europaea is not essential for production of gaseous nitrogen oxides and confers tolerance to nitrite.
Journal of bacteriology 2002;184(9):2557-60.
2002: Marcel H N Hoefnagel; Marjo Starrenburg; Dirk E Martens; Jeroen Hugenholtz; Michiel Kleerebezem; Iris I Van Swam; Roger S Bongers; Hans V Westerhoff; Jacky L Snoep
Metabolic engineering of lactic acid bacteria, the combined approach: kinetic modelling, metabolic control and experimental analysis.
Microbiology (Reading, England) 2002;148(Pt 4):1003-13.
2002: Jacky L Snoep; Coen C van der Weijden; Heidi W Andersen; Hans V Westerhoff; Peter R Jensen
DNA supercoiling in Escherichia coli is under tight and subtle homeostatic control, involving gene-expression and metabolic regulation of both topoisomerase I and DNA gyrase.
European journal of biochemistry / FEBS 2002;269(6):1662-9.
2002: Fernando Ortega; Luis Acerenza; Hans V Westerhoff; Francesc Mas; Marta Cascante
Product dependence and bifunctionality compromise the ultrasensitivity of signal transduction cascades.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1170-5.
2002: Catholijn M Jonker; Jacky L Snoep; Jan Treur; Hans V Westerhoff; Wouter C A Wijngaards
Putting intentions into cell biochemistry: an artificial intelligence perspective.
Journal of theoretical biology 2002;214(1):105-34.
2002: Bart J van Rotterdam; Wim Crielaard; Ivo H M van Stokkum; Klaas J Hellingwerf; Hans V Westerhoff
Simplicity in complexity: the photosynthetic reaction center performs as a simple 0.2 V battery.
FEBS letters 2002;510(1-2):105-7.
2002: Rogier Stuger; Conrad L Woldringh; Coen C van der Weijden; Norbert O E Vischer; Barbara M Bakker; Rob J M van Spanning; Jacky L Snoep; Hans V Westerhoff
DNA supercoiling by gyrase is linked to nucleoid compaction.
Molecular biology reports 2002;29(1-2):79-82.
2002: Brian J Koebmann; Hans V Westerhoff; Jacky L Snoep; Christian Solem; Martin Pedersen; Dan Nilsson; Ole Michelsen; Peter R Jensen
The extent to which ATP demand controls the glycolytic flux depends strongly on the organism and conditions for growth.
Molecular biology reports 2002;29(1-2):41-5.
2002: Sergio Rossell; Coen C van der Weijden; Arthur L Kruckeberg; Barbara M Bakker; Hans V Westerhoff
Loss of fermentative capacity in baker's yeast can partly be explained by reduced glucose uptake capacity.
Molecular biology reports 2002;29(1-2):255-7.
2002: Fernando Ortega; Måns Ehrenberg; Luis Acerenza; Hans V Westerhoff; Francesc Mas; Marta Cascante
Sensitivity analysis of metabolic cascades catalyzed by bifunctional enzymes.
Molecular biology reports 2002;29(1-2):211-5.
2002: Christof Francke; Hans V Westerhoff; Joke G Blom; Mark A Peletier
Flux control of the bacterial phosphoenolpyruvate:glucose phosphotransferase system and the effect of diffusion.
Molecular biology reports 2002;29(1-2):21-6.
2002: Hans V Westerhoff; Wayne M Getz; Frank Bruggeman; J H S Hofmeyr; Johann M Rohwer; Jacky L Snoep
ECA: control in ecosystems.
Molecular biology reports 2002;29(1-2):113-7.
2002: J H S Hofmeyr; Johann M Rohwer; Jacky L Snoep; Hans V Westerhoff; W N Konings
How to distinguish between the vacuum cleaner and flippase mechanisms of the lmrA multi-drug transporter in Lactococcus lactis.
Molecular biology reports 2002;29(1-2):107-12.
2002: Barbara M Bakker; Heike Assmus; Frank J Bruggeman; Jurgen Haanstra; Edda Klipp; Hans V Westerhoff
Network-based selectivity of antiparasitic inhibitors.
Molecular biology reports 2002;29(1-2):1-5.
2002: Hans V Westerhoff; W M Getz; Henk W van Verseveld; J H S Hofmeyr; Jacky L Snoep
Bioinformatics, cellular flows, and calculation.
Ernst Schering Research Foundation workshop 2002;(38):221-43.
2002: Karin A Reijenga; Hans V Westerhoff; Boris N Kholodenko; Jacky L Snoep
Control analysis for autonomously oscillating biochemical networks.
Biophysical journal 2002;82(1 Pt 1):99-108.
2001: Marijke Otten; J van der Oost; Willem N M Reijnders; Hans V Westerhoff; B Ludwig; Rob J M van Spanning
Cytochromes c(550), c(552), and c(1) in the electron transport network of Paracoccus denitrificans: redundant or subtly different in function?
Journal of bacteriology 2001;183(24):7017-26.
2001: Hans V Westerhoff
The silicon cell, not dead but live!
Metabolic engineering 2001;3(3):207-10.
2001: Marijke Otten; D M Stork; Willem N M Reijnders; Hans V Westerhoff; Rob J M van Spanning
Regulation of expression of terminal oxidases in Paracoccus denitrificans.
European journal of biochemistry / FEBS 2001;268(8):2486-97.
2001: J H S Hofmeyr; Hans V Westerhoff
Building the cellular puzzle: control in multi-level reaction networks.
Journal of theoretical biology 2001;208(3):261-85.
2001: Bart J van Rotterdam; Hans V Westerhoff; R W Visschers; Dima Bloch; Klaas J Hellingwerf; M R Jones; Wim Crielaard
Pumping capacity of bacterial reaction centers and backpressure regulation of energy transduction.
European journal of biochemistry / FEBS 2001;268(4):958-70.
2001: Karin A Reijenga; Jacky L Snoep; Jasper Diderich; Henk W van Verseveld; Hans V Westerhoff; Bas Teusink
Control of glycolytic dynamics by hexose transport in Saccharomyces cerevisiae.
Biophysical journal 2001;80(2):626-34.
2001: Léonie M Raamsdonk; Bas Teusink; David Broadhurst; N Zhang; Andrew Hayes; Michael C Walsh; Jan A Berden; K M Brindle; D B Kell; Jem J Rowland; Hans V Westerhoff; Karel van Dam; Stephen G Oliver
A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations.
Nature biotechnology 2001;19(1):45-50.
2000: Bart J van Rotterdam; Hans V Westerhoff; R W Visschers; M R Jones; Klaas J Hellingwerf; Wim Crielaard
Steady-state cyclic electron transfer through solubilized Rhodobacter sphaeroides reaction centres.
Biophysical chemistry 2000;88(1-3):137-52.
2000: Oscar J G Somsen; M A Hoeben; E Esgalhado; Jacky L Snoep; D Visser; Rob van der Heijden; J J Heijnen; Hans V Westerhoff
Glucose and the ATP paradox in yeast.
The Biochemical journal 2000;352 Pt 2():593-9.
2000: Johann M Rohwer; Norman D Meadow; Saul Roseman; Hans V Westerhoff; Pieter W Postma
Understanding glucose transport by the bacterial phosphoenolpyruvate:glycose phosphotransferase system on the basis of kinetic measurements in vitro.
The Journal of biological chemistry 2000;275(45):34909-21.
2000: Frank J Bruggeman; W C van Heeswijk; Fred C Boogerd; Hans V Westerhoff
Macromolecular intelligence in microorganisms.
Biological chemistry 2000;381(9-10):965-72.
2000: Neil Saunders; Jorrit J Hornberg; Willem N M Reijnders; Hans V Westerhoff; Simon de Vries; Rob J M van Spanning
The NosX and NirX proteins of Paracoccus denitrificans are functional homologues: their role in maturation of nitrous oxide reductase.
Journal of bacteriology 2000;182(18):5211-7.
2000: A P Jongsma; A Riethorst; Jan Lankelma; Henk Dekker; Hans V Westerhoff
Evaluating limited specificity of drug pumps reduced relative resistance in human MDR phenotypes.
European journal of biochemistry / FEBS 2000;267(17):5369-77.
2000: Hans V Westerhoff; A Riethorst; A P Jongsma
Relating multidrug resistance phenotypes to the kinetic properties of their drug-efflux pumps.
European journal of biochemistry / FEBS 2000;267(17):5355-68.
2000: Bas Teusink; Jutta Passarge; C A Reijenga; E Esgalhado; Coen C van der Weijden; M Schepper; Michael C Walsh; Barbara M Bakker; Karel van Dam; Hans V Westerhoff; Jacky L Snoep
Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry.
European journal of biochemistry / FEBS 2000;267(17):5313-29.
2000: D E Ward; Coen C van der Weijden; M J van Der Merwe; Hans V Westerhoff; Al Claiborne; Jacky L Snoep
Branched-chain alpha-keto acid catabolism via the gene products of the bkd operon in Enterococcus faecalis: a new, secreted metabolite serving as a temporary redox sink.
Journal of bacteriology 2000;182(11):3239-46.
2000: Bas Teusink; Hans V Westerhoff
'Slave' metabolites and enzymes. A rapid way of delineating metabolic control.
European journal of biochemistry / FEBS 2000;267(7):1889-93.
2000: Jana Wolf; Jutta Passarge; Oscar J G Somsen; Jacky L Snoep; Reinhart Heinrich; Hans V Westerhoff
Transduction of intracellular and intercellular dynamics in yeast glycolytic oscillations.
Biophysical journal 2000;78(3):1145-53.
2000: Barbara M Bakker; F I Mensonides; Bas Teusink; P van Hoek; Paul A M Michels; Hans V Westerhoff
Compartmentation protects trypanosomes from the dangerous design of glycolysis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2087-92.
2000: Barbara M Bakker; Hans V Westerhoff; Fred R Opperdoes; Paul A M Michels
Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs.
Molecular and biochemical parasitology 2000;106(1):1-10.
2000: peter wielinga; Hans V Westerhoff; Jan Lankelma
The relative importance of passive and P-glycoprotein mediated anthracycline efflux from multidrug-resistant cells.
European journal of biochemistry / FEBS 2000;267(3):649-57.
2000: Boris N Kholodenko; Hans V Westerhoff; James S Schwaber; M Cascante
Engineering a living cell to desired metabolite concentrations and fluxes: pathways with multifunctional enzymes.
Metabolic engineering 2000;2(1):1-13.
1999: peter wielinga; E de Waal; Hans V Westerhoff; Jan Lankelma
In vitro transepithelial drug transport by on-line measurement: cellular control of paracellular and transcellular transport.
Journal of pharmaceutical sciences 1999;88(12):1340-7.
1999: Peter R Jensen; Coen C van der Weijden; L B Jensen; Hans V Westerhoff; Jacky L Snoep
Extensive regulation compromises the extent to which DNA gyrase controls DNA supercoiling and growth rate of Escherichia coli.
European journal of biochemistry / FEBS 1999;266(3):865-77.
1999: Neil Saunders; Edith N G Houben; S Koefoed; S de Weert; Willem N M Reijnders; Hans V Westerhoff; AP de Boer; Rob J M van Spanning
Transcription regulation of the nir gene cluster encoding nitrite reductase of Paracoccus denitrificans involves NNR and NirI, a novel type of membrane protein.
Molecular microbiology 1999;34(1):24-36.
1999: Barbara M Bakker; Michael C Walsh; B H ter Kuile; F I Mensonides; Paul A M Michels; Fred R Opperdoes; Hans V Westerhoff
Contribution of glucose transport to the control of the glycolytic flux in Trypanosoma brucei.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10098-103.
1999: Rob J M van Spanning; Edith N G Houben; Willem N M Reijnders; Stephen Spiro; Hans V Westerhoff; Neil Saunders
Nitric oxide is a signal for NNR-mediated transcription activation in Paracoccus denitrificans.
Journal of bacteriology 1999;181(13):4129-32.
1999: Barbara M Bakker; Paul A M Michels; Fred R Opperdoes; Hans V Westerhoff
What controls glycolysis in bloodstream form Trypanosoma brucei?
The Journal of biological chemistry 1999;274(21):14551-9.
1999: Marijke Otten; Willem N M Reijnders; J J Bedaux; Hans V Westerhoff; Klaas Krab; Rob J M van Spanning
The reduction state of the Q-pool regulates the electron flux through the branched respiratory network of Paracoccus denitrificans.
European journal of biochemistry / FEBS 1999;261(3):767-74.
1999: W C van Heeswijk; Barbara M Bakker; Bas Teusink; Boris N Kholodenko; Oscar J G Somsen; Jacky L Snoep; Hans V Westerhoff
Live control of the living cell.
Biochemical Society transactions 1999;27(2):261-4.
1999: S Schuster; Hans V Westerhoff
Modular control analysis of slipping enzymes.
Bio Systems 1999;49(1):1-15.
1998: peter wielinga; Marc Heijn; Hans V Westerhoff; Jan Lankelma
A method for studying plasma membrane transport with intact cells using computerized fluorometry.
Analytical biochemistry 1998;263(2):221-31.
1998: Johann M Rohwer; Pieter W Postma; Boris N Kholodenko; Hans V Westerhoff
Implications of macromolecular crowding for signal transduction and metabolite channeling.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10547-52.
1998: Boris N Kholodenko; M Cascante; Jan B Hoek; Hans V Westerhoff; James S Schwaber
Metabolic design: how to engineer a living cell to desired metabolite concentrations and fluxes.
Biotechnology and bioengineering 1998;59(2):239-47.
1998: Boris N Kholodenko; Johann M Rohwer; M Cascante; Hans V Westerhoff
Subtleties in control by metabolic channelling and enzyme organization.
Molecular and cellular biochemistry 1998;184(1-2):311-20.
1998: Johann M Rohwer; Rechien Bader; Hans V Westerhoff; Pieter W Postma
Limits to inducer exclusion: inhibition of the bacterial phosphotransferase system by glycerol kinase.
Molecular microbiology 1998;29(2):641-52.
1998: Bas Teusink; Michael C Walsh; Karel van Dam; Hans V Westerhoff
The danger of metabolic pathways with turbo design.
Trends in biochemical sciences 1998;23(5):162-9.
1998: B N Kholodenko; S Schuster; J Garcia; Hans V Westerhoff; Marta Cascante
Control analysis of metabolic systems involving quasi-equilibrium reactions.
Biochimica et biophysica acta 1998;1379(3):337-52.
1998: Bas Teusink; Jasper Diderich; Hans V Westerhoff; Karel van Dam; Michael C Walsh
Intracellular glucose concentration in derepressed yeast cells consuming glucose is high enough to reduce the glucose transport rate by 50%.
Journal of bacteriology 1998;180(3):556-62.
1997: Boris N Kholodenko; Jan B Hoek; Hans V Westerhoff; G C Brown
Quantification of information transfer via cellular signal transduction pathways.
FEBS letters 1997;414(2):430-4.
1997: Marc Heijn; Jan Hendrik Hooijberg; George L Scheffer; G Szabó; Hans V Westerhoff; Jan Lankelma
Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport.
Biochimica et biophysica acta 1997;1326(1):12-22.
1997: Rob J M van Spanning; AP de Boer; Willem N M Reijnders; Hans V Westerhoff; AH Stouthamer; J van der Oost
FnrP and NNR of Paracoccus denitrificans are both members of the FNR family of transcriptional activators but have distinct roles in respiratory adaptation in response to oxygen limitation.
Molecular microbiology 1997;23(5):893-907.
1997: A A van der Gugten; Hans V Westerhoff
Internal regulation of a modular system: the different faces of internal control.
Bio Systems 1997;44(2):79-106.
1996: A P de Boer; J van der Oost; Willem N M Reijnders; Hans V Westerhoff; AH Stouthamer; Rob J M van Spanning
Mutational analysis of the nor gene cluster which encodes nitric-oxide reductase from Paracoccus denitrificans.
European journal of biochemistry / FEBS 1996;242(3):592-600.
1996: Martin Bier; Bas Teusink; Boris N Kholodenko; Hans V Westerhoff
Control analysis of glycolytic oscillations.
Biophysical chemistry 1996;62(1-3):15-24.
1996: Bas Teusink; C Larsson; Jasper Diderich; P Richard; Karel van Dam; L Gustafsson; Hans V Westerhoff
Synchronized heat flux oscillations in yeast cell populations.
The Journal of biological chemistry 1996;271(40):24442-8.
1996: J van der Oost; P H Nederkoorn; AH Stouthamer; Hans V Westerhoff; Rob J M van Spanning
An alternative model for haem ligation in nitrate reductase and analogous respiratory cytochrome b complexes.
Molecular microbiology 1996;22(1):193-6.
1996: Bas Teusink; Barbara M Bakker; Hans V Westerhoff
Control of frequency and amplitudes is shared by all enzymes in three models for yeast glycolytic oscillations.
Biochimica et biophysica acta 1996;1275(3):204-12.
1996: Jacky L Snoep; N Arfman; Lorraine P Yomano; Hans V Westerhoff; Tyrrell Conway; Lonnie O Ingram
Control of glycolytic flux in Zymomonas mobilis by glucose 6-phosphate dehydrogenase activity.
Biotechnology and bioengineering 1996;51(2):190-7.
1996: W C van Heeswijk; Sjouke Hoving; Dylan Molenaar; B Stegeman; D Kahn; Hans V Westerhoff
An alternative PII protein in the regulation of glutamine synthetase in Escherichia coli.
Molecular microbiology 1996;21(1):133-46.
1996: P Richard; Bas Teusink; M B Hemker; Karel van Dam; Hans V Westerhoff
Sustained oscillations in free-energy state and hexose phosphates in yeast.
Yeast (Chichester, England) 1996;12(8):731-40.
1996: Johann M Rohwer; S Schuster; Hans V Westerhoff
How to recognize monofunctional units in a metabolic system.
Journal of theoretical biology 1996;179(3):213-28.
1996: M van Workum; S J van Dooren; N Oldenburg; Dylan Molenaar; Peter R Jensen; Jacky L Snoep; Hans V Westerhoff
DNA supercoiling depends on the phosphorylation potential in Escherichia coli.
Molecular microbiology 1996;20(2):351-60.
1996: P Richard; Barbara M Bakker; Bas Teusink; Karel van Dam; Hans V Westerhoff
Acetaldehyde mediates the synchronization of sustained glycolytic oscillations in populations of yeast cells.
European journal of biochemistry / FEBS 1996;235(1-2):238-41.
1996: Johann M Rohwer; P R Jensen; Y Shinohara; Pieter W Postma; Hans V Westerhoff
Changes in the cellular energy state affect the activity of the bacterial phosphotransferase system.
European journal of biochemistry / FEBS 1996;235(1-2):225-30.
1995: Peter R Jensen; O Michelsen; Hans V Westerhoff
Experimental determination of control by the H(+)-ATPase in Escherichia coli.
Journal of bioenergetics and biomembranes 1995;27(6):543-54.
1995: V Mildaziene; R Baniene; Z Nauciene; Barbara M Bakker; G C Brown; Hans V Westerhoff; Boris N Kholodenko
Calcium indirectly increases the control exerted by the adenine nucleotide translocator over 2-oxoglutarate oxidation in rat heart mitochondria.
Archives of biochemistry and biophysics 1995;324(1):130-4.
1995: Boris N Kholodenko; Dylan Molenaar; S Schuster; R Heinrich; Hans V Westerhoff
Defining control coefficients in non-ideal metabolic pathways.
Biophysical chemistry 1995;56(3):215-26.
1995: Barbara M Bakker; Hans V Westerhoff; Paul A M Michels
Regulation and control of compartmentalized glycolysis in bloodstream form Trypanosoma brucei.
Journal of bioenergetics and biomembranes 1995;27(5):513-25.
1995: Rob J M van Spanning; A P de Boer; Willem N M Reijnders; Jan-Willem de Gier; C O Delorme; AH Stouthamer; Hans V Westerhoff; Nellie Harms; J van der Oost
Regulation of oxidative phosphorylation: the flexible respiratory network of Paracoccus denitrificans.
Journal of bioenergetics and biomembranes 1995;27(5):499-512.
1995: Hans V Westerhoff; B N Kholodenko; Marta Cascante; K Van Dam
Elusive control.
Journal of bioenergetics and biomembranes 1995;27(5):491-7.
1995: W C van Heeswijk; B Stegeman; Sjouke Hoving; Dylan Molenaar; D Kahn; Hans V Westerhoff
An additional PII in Escherichia coli: a new regulatory protein in the glutamine synthetase cascade.
FEMS microbiology letters 1995;132(1-2):153-7.
1995: Conrad L Woldringh; P R Jensen; Hans V Westerhoff
Structure and partitioning of bacterial DNA: determined by a balance of compaction and expansion forces?
FEMS microbiology letters 1995;131(3):235-42.
1995: J van der Oost; M Schepper; AH Stouthamer; Hans V Westerhoff; Rob J M van Spanning; Jan-Willem de Gier
Reversed electron transfer through the bc1 complex enables a cytochrome c oxidase mutant (delta aa3/cbb3) of Paracoccus denitrificans to grow on methylamine.
FEBS letters 1995;371(3):267-70.
1995: Boris N Kholodenko; S Schuster; Johann M Rohwer; Marta Cascante; Hans V Westerhoff
Composite control of cell function: metabolic pathways behaving as single control units.
FEBS letters 1995;368(1):1-4.
1995: K J Hellingwerf; Pieter W Postma; J Tommassen; Hans V Westerhoff
Signal transduction in bacteria: phospho-neural network(s) in Escherichia coli?
FEMS microbiology reviews 1995;16(4):309-21.
1995: Hans V Westerhoff
Subtlety in control--metabolic pathway engineering.
Trends in biotechnology 1995;13(7):242-4.
1995: Peter R Jensen; L Loman; B Petra; Coen C van der Weijden; Hans V Westerhoff
Energy buffering of DNA structure fails when Escherichia coli runs out of substrate.
Journal of bacteriology 1995;177(12):3420-6.
1995: Peter R Jensen; Jacky L Snoep; Dylan Molenaar; W C van Heeswijk; Boris N Kholodenko; A A van der Gugten; Hans V Westerhoff
Molecular biology for flux control.
Biochemical Society transactions 1995;23(2):367-70.
1995: Hans V Westerhoff; Cees J A van Echteld; J A Jeneson
On the expected relationship between Gibbs energy of ATP hydrolysis and muscle performance.
Biophysical chemistry 1995;54(2):137-42.
1995: Boris N Kholodenko; H M Sauro; Hans V Westerhoff; Marta Cascante
Coenzyme cycles and metabolic control analysis: the determination of the elasticity coefficients from the generalised connectivity theorem.
Biochemistry and molecular biology international 1995;35(3):615-25.
1995: Hans V Westerhoff; M Zasloff; J L Rosner; Richard W Hendler; A De Waal; A Vaz Gomes; P M Jongsma; A Riethorst; D Juretić
Functional synergism of the magainins PGLa and magainin-2 in Escherichia coli, tumor cells and liposomes.
European journal of biochemistry / FEBS 1995;228(2):257-64.
1995: Rob J M van Spanning; A P De Boer; Willem N M Reijnders; Stephen Spiro; Hans V Westerhoff; AH Stouthamer; J Van der Oost
Nitrite and nitric oxide reduction in Paracoccus denitrificans is under the control of NNR, a regulatory protein that belongs to the FNR family of transcriptional activators.
FEBS letters 1995;360(2):151-4.
1995: Boris N Kholodenko; Marta Cascante; Hans V Westerhoff
Control theory of metabolic channelling.
Molecular and cellular biochemistry 1995;143(2):151-68.
1995: Boris N Kholodenko; Hans V Westerhoff
The macroworld versus the microworld of biochemical regulation and control.
Trends in biochemical sciences 1995;20(2):52-4.
1994: Boris N Kholodenko; Hans V Westerhoff
Control theory of one enzyme.
Biochimica et biophysica acta 1994;1208(2):294-305.
1994: Boris N Kholodenko; H M Sauro; Hans V Westerhoff
Control by enzymes, coenzymes and conserved moieties. A generalisation of the connectivity theorem of metabolic control analysis.
European journal of biochemistry / FEBS 1994;225(1):179-86.
1994: Jacky L Snoep; Peter R Jensen; Philip Groeneveld; Dylan Molenaar; Boris N Kholodenko; Hans V Westerhoff
How to determine control of growth rate in a chemostat. Using metabolic control analysis to resolve the paradox.
Biochemistry and molecular biology international 1994;33(5):1023-32.
1994: Boris N Kholodenko; Hans V Westerhoff; G C Brown
Rate limitation within a single enzyme is directly related to enzyme intermediate levels.
FEBS letters 1994;349(1):131-4.
1994: Hans V Westerhoff; J H Hofmeyr; Boris N Kholodenko
Getting to the inside of cells using metabolic control analysis.
Biophysical chemistry 1994;50(3):273-83.
1994: D Juretić; Richard W Hendler; F Kamp; W S Caughey; M Zasloff; Hans V Westerhoff
Magainin oligomers reversibly dissipate delta microH+ in cytochrome oxidase liposomes.
Biochemistry 1994;33(15):4562-70.
1994: Boris N Kholodenko; Marta Cascante; Hans V Westerhoff
Control theory of metabolic channelling.
Molecular and cellular biochemistry 1994;133-134():313-31.
1994: P Richard; Jasper Diderich; Barbara M Bakker; Bas Teusink; Karel van Dam; Hans V Westerhoff
Yeast cells with a specific cellular make-up and an environment that removes acetaldehyde are prone to sustained glycolytic oscillations.
FEBS letters 1994;341(2-3):223-6.
1993: S Schuster; D Kahn; Hans V Westerhoff
Modular analysis of the control of complex metabolic pathways.
Biophysical chemistry 1993;48(1):1-17.
1993: Peter R Jensen; O Michelsen; Hans V Westerhoff
Control analysis of the dependence of Escherichia coli physiology on the H(+)-ATPase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(17):8068-72.
1993: W C van Heeswijk; M Rabenberg; Hans V Westerhoff; D Kahn
The genes of the glutamine synthetase adenylylation cascade are not regulated by nitrogen in Escherichia coli.
Molecular microbiology 1993;9(3):443-57.
1993: D Kahn; Hans V Westerhoff
The regulatory strength: how to be precise about regulation and homeostasis.
Acta biotheoretica 1993;41(1-2):85-96.
1993: Hans V Westerhoff; D Kahn
Control involving metabolism and gene expression: the square-matrix method for modular decomposition.
Acta biotheoretica 1993;41(1-2):75-83.
1993: A Vaz Gomes; A de Waal; J A Berden; Hans V Westerhoff
Electric potentiation, cooperativity, and synergism of magainin peptides in protein-free liposomes.
Biochemistry 1993;32(20):5365-72.
1993: Peter R Jensen; Hans V Westerhoff; O Michelsen
Excess capacity of H(+)-ATPase and inverse respiratory control in Escherichia coli.
The EMBO journal 1993;12(4):1277-82.
1993: Boris N Kholodenko; Oleg Demin; Hans V Westerhoff
'Channelled' pathways can be more sensitive to specific regulatory signals.
FEBS letters 1993;320(1):75-8.
1993: Boris N Kholodenko; Hans V Westerhoff
Metabolic channelling and control of the flux.
FEBS letters 1993;320(1):71-4.
1993: Karel van Dam; Johan Van der Vlag; Boris N Kholodenko; Hans V Westerhoff
The sum of the control coefficients of all enzymes on the flux through a group-transfer pathway can be as high as two.
European journal of biochemistry / FEBS 1993;212(3):791-9.
1993: P Richard; Bas Teusink; Hans V Westerhoff; Karel van Dam
Around the growth phase transition S. cerevisiae's make-up favours sustained oscillations of intracellular metabolites.
FEBS letters 1993;318(1):80-2.
1993: Peter R Jensen; Hans V Westerhoff; O Michelsen
The use of lac-type promoters in control analysis.
European journal of biochemistry / FEBS 1993;211(1-2):181-91.
1993: B Vosman; P J Rauch; Hans V Westerhoff; Klaas J Hellingwerf
Regulation of the expression of the Pseudomonas stutzeri recA gene.
Antonie van Leeuwenhoek 1993;63(1):55-62.
1992: Richard W Hendler; Hans V Westerhoff
Redox interactions in cytochrome c oxidase: from the "neoclassical" toward "modern" models.
Biophysical journal 1992;63(6):1586-604.
1992: H J Stoffers; E L Sonnhammer; G J Blommestijn; N J Raat; Hans V Westerhoff
METASIM: object-oriented modelling of cell regulation.
Computer applications in the biosciences : CABIOS 1992;8(5):443-9.
1992: Hans V Westerhoff; G R Welch
Enzyme organization and the direction of metabolic flow: physicochemical considerations.
Current topics in cellular regulation 1992;33():361-90.
1991: D Kahn; Hans V Westerhoff
Control theory of regulatory cascades.
Journal of theoretical biology 1991;153(2):255-85.
1991: A de Waal; A Vaz Gomes; A Mensink; J A Grootegoed; Hans V Westerhoff
Magainins affect respiratory control, membrane potential and motility of hamster spermatozoa.
FEBS letters 1991;293(1-2):219-23.
1991: Sonia Cortassa; Miguel A Aon; Hans V Westerhoff
Linear nonequilibrium thermodynamics describes the dynamics of an autocatalytic system.
Biophysical journal 1991;60(4):794-803.
1991: Hans V Westerhoff; W van Heeswijk; D Kahn; D B Kell
Quantitative approaches to the analysis of the control and regulation of microbial metabolism.
Antonie van Leeuwenhoek 1991;60(3-4):193-207.
1991: Hans V Westerhoff
Energetics and control aspects of channelling.
Journal of theoretical biology 1991;152(1):123-30.
1991: Miguel A Aon; Sonia Cortassa; Hans V Westerhoff; J A Berden; E Van Spronsen; Karel van Dam
Dynamic regulation of yeast glycolytic oscillations by mitochondrial functions.
Journal of cell science 1991;99 ( Pt 2)():325-34.
1989: Hans V Westerhoff; D Juretić; Richard W Hendler; M Zasloff
Magainins and the disruption of membrane-linked free-energy transduction.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6597-601.
1989: G A Kuijpers; J J De Pont; Hans V Westerhoff
A model for fluid secretion in the exocrine pancreas.
Biochimica et biophysica acta 1989;984(1):71-80.
1989: Hans V Westerhoff; Richard W Hendler; M Zasloff; D Juretić
Interactions between a new class of eukaryotic antimicrobial agents and isolated rat liver mitochondria.
Biochimica et biophysica acta 1989;975(3):361-9.
1989: D Juretić; H C Chen; J H Brown; J L Morell; Richard W Hendler; Hans V Westerhoff
Magainin 2 amide and analogues. Antimicrobial activity, membrane depolarization and susceptibility to proteolysis.
FEBS letters 1989;249(2):219-23.
1988: J G Koster; Olivier Destrée; Hans V Westerhoff
Kinetics of histone gene expression during early development of Xenopus laevis.
Journal of theoretical biology 1988;135(2):139-67.
1988: R J Wanders; Hans V Westerhoff
Sigmoidal relation between mitochondrial respiration and log ([ATP]/[ADP])out under conditions of extramitochondrial ATP utilization. Implications for the control and thermodynamics of oxidative phosphorylation.
Biochemistry 1988;27(20):7832-40.
1988: F Kamp; Y D Chen; Hans V Westerhoff
Energization-induced redistribution of charge carriers near membranes.
Biophysical chemistry 1988;30(2):113-32.
1988: F Kamp; G R Welch; Hans V Westerhoff
Energy coupling and Hill cycles in enzymatic processes.
Cell biophysics 1988;12():201-36.
1988: Hans V Westerhoff; Mary H O'Dea; Anthony Maxwell; Martin Gellert
DNA supercoiling by DNA gyrase. A static head analysis.
Cell biophysics 1988;12():157-81.
1987: Hans V Westerhoff; P J Plomp; A K Groen; R J Wanders
Thermodynamics of the control of metabolism.
Cell biophysics 1987;11():239-67.
1987: Hans V Westerhoff; P J Plomp; A K Groen; R J Wanders; J A Bode; K van Dam
On the origin of the limited control of mitochondrial respiration by the adenine nucleotide translocator.
Archives of biochemistry and biophysics 1987;257(1):154-69.