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Karen Westerman

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Procedures

Cell Transplantation

Physiology

Devices

Liver, Artificial

Co-author Network

Publications

TOP 3
Toshinori Totsugawa; Chen Yong; Jorge David Rivas-Carrillo; Alejandro Soto-Gutierrez; Nalu Navarro-Alvarez; Hirofumi Noguchi; Teru Okitsu; Karen A Westerman; Michinori Kohara; Michael Reth; Noriaki Tanaka; Philippe Leboulch; Naoya Kobayashi
Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with Tamoxifen-mediated self-recombination.
Hui-Ying Qiu; Yoshihiro Fujimori; Keisuke Nishioka; Nobuko Yamaguchi; Tomoko Hashimoto-Tamaoki; Ayako Sugihara; Nobuyuki Terada; Noritoshi Nagaya; Munetake Kanda; Naoya Kobayashi; Noriaki Tanaka; Karen A Westerman; Philippe Leboulch; Hiroshi Hara
Postnatal neovascularization by endothelial progenitor cells immortalized with the simian virus 40T antigen gene.
Michiki Narushima; Naoya Kobayashi; Teru Okitsu; Yoshihito Tanaka; Shun-Ai Li; Yong Chen; Atsushi Miki; Kimiaki Tanaka; Shuhei Nakaji; Kohji Takei; Alejandro Soto Gutierrez; Jorge David Rivas-Carrillo; Nalu Navarro-Alvarez; Hee-Sook Jun; Karen A Westerman; Hirofumi Noguchi; Jonathan R T Lakey; Philippe Leboulch; Noriaki Tanaka; Ji-Won Yoon
A human beta-cell line for transplantation therapy to control type 1 diabetes.

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All Publications

2007: Toshinori Totsugawa; Chen Yong; Jorge David Rivas-Carrillo; Alejandro Soto-Gutierrez; Nalu Navarro-Alvarez; Hirofumi Noguchi; Teru Okitsu; Karen A Westerman; Michinori Kohara; Michael Reth; Noriaki Tanaka; Philippe Leboulch; Naoya Kobayashi
Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with Tamoxifen-mediated self-recombination.
Journal of hepatology 2007;47(1):74-82.
2006: Hui-Ying Qiu; Yoshihiro Fujimori; Keisuke Nishioka; Nobuko Yamaguchi; Tomoko Hashimoto-Tamaoki; Ayako Sugihara; Nobuyuki Terada; Noritoshi Nagaya; Munetake Kanda; Naoya Kobayashi; Noriaki Tanaka; Karen A Westerman; Philippe Leboulch; Hiroshi Hara
Postnatal neovascularization by endothelial progenitor cells immortalized with the simian virus 40T antigen gene.
International journal of oncology 2006;28(4):815-21.
2005: Michiki Narushima; Naoya Kobayashi; Teru Okitsu; Yoshihito Tanaka; Shun-Ai Li; Yong Chen; Atsushi Miki; Kimiaki Tanaka; Shuhei Nakaji; Kohji Takei; Alejandro Soto Gutierrez; Jorge David Rivas-Carrillo; Nalu Navarro-Alvarez; Hee-Sook Jun; Karen A Westerman; Hirofumi Noguchi; Jonathan R T Lakey; Philippe Leboulch; Noriaki Tanaka; Ji-Won Yoon
A human beta-cell line for transplantation therapy to control type 1 diabetes.
Nature biotechnology 2005;23(10):1274-82.
2004: Suzan Imren; Mary E Fabry; Karen A Westerman; Robert Pawliuk; Patrick Tang; Patricia M Rosten; Ronald L Nagel; Philippe Leboulch; Connie J Eaves; R Keith Humphries
High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells.
The Journal of clinical investigation 2004;114(7):953-62.
2004: Toshihisa Matsumura; Michihiko Takesue; Karen A Westerman; Teru Okitsu; Masakiyo Sakaguchi; Takuya Fukazawa; Toshinori Totsugawa; Hirofumi Noguchi; Shinichiro Yamamoto; Donna B Stolz; Noriaki Tanaka; Philippe Leboulch; Naoya Kobayashi
Establishment of an immortalized human-liver endothelial cell line with SV40T and hTERT.
Transplantation 2004;77(9):1357-65.
2004: Masanobu Maruyama; Naoya Kobayashi; Karen A Westerman; Masakiyo Sakaguchi; Jean-Etienne Allain; Toshinori Totsugawa; Teru Okitsu; Takuya Fukazawa; Anne Weber; Donna B Stolz; Philippe Leboulch; Noriaki Tanaka
Establishment of a highly differentiated immortalized human cholangiocyte cell line with SV40T and hTERT.
Transplantation 2004;77(3):446-51.
2004: Teru Okitsu; Naoya Kobayashi; Hee-Sook Jun; Seungjin Shin; Su-Jin Kim; Jaeseok Han; Hyok Joon Kwon; Masakiyo Sakaguchi; Toshinori Totsugawa; Michinori Kohara; Karen A Westerman; Noriaki Tanaka; Philippe Leboulch; Ji-Won Yoon
Transplantation of reversibly immortalized insulin-secreting human hepatocytes controls diabetes in pancreatectomized pigs.
Diabetes 2004;53(1):105-12.
2003: Keisuke Nishioka; Yoshihiro Fujimori; Tomoko Hashimoto-Tamaoki; Shunro Kai; Huiying Qiu; Naoya Kobayashi; Noriaki Tanaka; Karen A Westerman; Philippe Leboulch; Hiroshi Hara
Immortalization of bone marrow-derived human mesenchymal stem cells by removable simian virus 40T antigen gene: analysis of the ability to support expansion of cord blood hematopoietic progenitor cells.
International journal of oncology 2003;23(4):925-32.
2003: Takamasa Watanabe; Norikuni Shibata; Karen A Westerman; Teru Okitsu; Jean-Etienne Allain; Masakiyo Sakaguchi; Toshinori Totsugawa; Masanobu Maruyama; Toshihisa Matsumura; Hirofumi Noguchi; Shinichiro Yamamoto; Masaki Hikida; Akira Ohmori; Michael Reth; Anne Weber; Noriaki Tanaka; Philippe Leboulch; Naoya Kobayashi
Establishment of immortalized human hepatic stellate scavenger cells to develop bioartificial livers.
Transplantation 2003;75(11):1873-80.
2002: Suzan Imren; Emmanuel Payen; Karen A Westerman; Robert Pawliuk; Mary E Fabry; Connie J Eaves; Benjamin Cavilla; Louis D Wadsworth; Yves Beuzard; Eric E Bouhassira; Robert Russell; Irving M London; Ronald L Nagel; Philippe Leboulch; R Keith Humphries
Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14380-5.
2002: Jin Cai; Masahiro Ito; Hideo Nagata; Karen A Westerman; Daryl Lafleur; Jayanta Roy-Chowdhury; Philippe Leboulch; Ira J Fox
Treatment of liver failure in rats with end-stage cirrhosis by transplantation of immortalized hepatocytes.
Hepatology (Baltimore, Md.) 2002;36(2):386-94.
2002: Jean-Etienne Allain; Ibrahim Dagher; Dominique Mahieu-Caputo; Nathalie Loux; Marion Andreoletti; Karen A Westerman; Pascale Briand; Dominique Franco; Philippe Leboulch; Anne Weber
Immortalization of a primate bipotent epithelial liver stem cell.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3639-44.
2002: Hirofumi Noguchi; Naoya Kobayashi; Karen A Westerman; Masakiyo Sakaguchi; Teru Okitsu; Toshinori Totsugawa; Takamasa Watanabe; Toshihisa Matsumura; Toshiyoshi Fujiwara; Tadayoshi Ueda; Masahiro Miyazaki; Noriaki Tanaka; Philippe Leboulch
Controlled expansion of human endothelial cell populations by Cre-loxP-based reversible immortalization.
Human gene therapy 2002;13(2):321-34.
2001: Robert Pawliuk; Karen A Westerman; Mary E Fabry; Emmanuel Payen; robert Tighe; Eric E Bouhassira; Seetharama A Acharya; James Ellis; Irving M London; Connie J Eaves; R Keith Humphries; Yves Beuzard; Ronald L Nagel; Philippe Leboulch
Correction of sickle cell disease in transgenic mouse models by gene therapy.
Science (New York, N.Y.) 2001;294(5550):2368-71.
2001: N Kobayashi; Karen A Westerman; T Taguchi; M Sakaguchi; Toshiyoshi Fujiwara; H Urata; N Kishimoto; N Hayashi; S Nakaji; T Murakami; Philippe Leboulch; Noriaki Tanaka
Expansion of human hepatocyte populations by a retroviral gene transfer of simian virus 40 large T antigen.
ASAIO journal (American Society for Artificial Internal Organs : 1992) 2001;47(5):481-5.
2001: N Kobayashi; Masahiro Miyazaki; Karen A Westerman; H Noguchi; M Sakaguchi; Toshinori Totsugawa; T Watanabe; T Matsumura; Toshiyoshi Fujiwara; Philippe Leboulch; Noriaki Tanaka; Masayoshi Namba
Construction of a differentiated human hepatocyte cell line expressing the herpes simplex virus-thymidine kinase gene.
ASAIO journal (American Society for Artificial Internal Organs : 1992) 2001;47(5):476-80.
2001: N Kobayashi; H Noguchi; Karen A Westerman; T Watanabe; T Matsumura; Toshinori Totsugawa; Toshiyoshi Fujiwara; Philippe Leboulch; Noriaki Tanaka
Cre/loxP-based reversible immortalization of human hepatocytes.
Cell transplantation 2001;10(4-5):383-6.
2001: N Kobayashi; H Noguchi; Karen A Westerman; T Watanabe; T Matsumura; Toshinori Totsugawa; Toshiyoshi Fujiwara; Philippe Leboulch; Noriaki Tanaka
Successful retroviral gene transfer of simian virus 40 T antigen and herpes simplex virus-thymidine kinase into human hepatocytes.
Cell transplantation 2001;10(4-5):377-81.
2000: N Kobayashi; H Noguchi; T Watanabe; T Matsumura; Toshinori Totsugawa; Toshiyoshi Fujiwara; T Taguchi; H Urata; N Kishimoto; N Hayashi; S Nakaji; Karen A Westerman; Philippe Leboulch; T Murakami; Noriaki Tanaka
A new approach to develop a biohybrid artificial liver using a tightly regulated human hepatocyte cell line.
Human cell 2000;13(4):229-35.
2000: N Kobayashi; H Noguchi; Toshiyoshi Fujiwara; Karen A Westerman; Philippe Leboulch; Noriaki Tanaka
Establishment of a highly differentiated immortalized adult human hepatocyte cell line by retroviral gene transfer.
Transplantation proceedings 2000;32(7):2368-9.
2000: Jin Cai; Masahiro Ito; Karen A Westerman; N Kobayashi; Philippe Leboulch; Ira J Fox
Construction of a non-tumorigenic rat hepatocyte cell line for transplantation: reversal of hepatocyte immortalization by site-specific excision of the SV40 T antigen.
Journal of hepatology 2000;33(5):701-8.
2000: N Kobayashi; H Noguchi; Karen A Westerman; T Matsumura; T Watanabe; Toshinori Totsugawa; Toshiyoshi Fujiwara; Philippe Leboulch; Noriaki Tanaka
Efficient Cre/loxP site-specific recombination in a HepG2 human liver cell line.
Cell transplantation 2000;9(5):737-42.
2000: N Kobayashi; H Noguchi; T Watanabe; T Matsumura; Toshinori Totsugawa; Toshiyoshi Fujiwara; Karen A Westerman; Philippe Leboulch; Ira J Fox; Noriaki Tanaka
Establishment of a tightly regulated human cell line for the development of hepatocyte transplantation.
Human cell 2000;13(1):7-13.
2000: N Kobayashi; T Fujiwara; Karen A Westerman; Y Inoue; M Sakaguchi; H Noguchi; M Miyazaki; J Cai; N Tanaka; Ira J Fox; Philippe Leboulch
Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes.
Science (New York, N.Y.) 2000;287(5456):1258-62.
1999: Yong-Qing Feng; Jost Seibler; Raouf Alami; A Eisen; Karen A Westerman; Philippe Leboulch; Steven Fiering; Eric E Bouhassira
Site-specific chromosomal integration in mammalian cells: highly efficient CRE recombinase-mediated cassette exchange.
Journal of molecular biology 1999;292(4):779-85.
1997: Eric E Bouhassira; Karen A Westerman; Philippe Leboulch
Transcriptional behavior of LCR enhancer elements integrated at the same chromosomal locus by recombinase-mediated cassette exchange.
Blood 1997;90(9):3332-44.