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Heiner Westphal

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Ginat Narkis; Itai Tzchori; Tsadok Cohen; Alex Holtz; Eric Wier; Heiner Westphal
Isl1 and Ldb co-regulators of transcription are essential early determinants of mouse limb development.
Hadas Hezroni; Anna Mattout; Alva Biran; Anna Davidi; Malka Nissim-Rafinia; Itai Tzchori; Heiner Westphal; Eran Meshorer
H3K9 histone acetylation predicts pluripotency and reprogramming capacity of ES cells.
LiQi Li; Raja Jothi; Kairong Cui; Jan Y Lee; Tsadok Cohen; Marat Gorivodsky; Itai Tzchori; Yangu Zhao; Sandra M Hayes; Emery H Bresnick; Keji Zhao; Heiner Westphal; Paul E Love
Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells.

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All Publications

2012: Ginat Narkis; Itai Tzchori; Tsadok Cohen; Alex Holtz; Eric Wier; Heiner Westphal
Isl1 and Ldb co-regulators of transcription are essential early determinants of mouse limb development.
Developmental dynamics : an official publication of the American Association of Anatomists 2012;241(4):787-91.
2011: Hadas Hezroni; Anna Mattout; Alva Biran; Anna Davidi; Malka Nissim-Rafinia; Itai Tzchori; Heiner Westphal; Eran Meshorer
H3K9 histone acetylation predicts pluripotency and reprogramming capacity of ES cells.
Nucleus (Austin, Tex.) 2011;2(4):300-9.
2011: LiQi Li; Raja Jothi; Kairong Cui; Jan Y Lee; Tsadok Cohen; Marat Gorivodsky; Itai Tzchori; Yangu Zhao; Sandra M Hayes; Emery H Bresnick; Keji Zhao; Heiner Westphal; Paul E Love
Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells.
Nature immunology 2011;12(2):129-36.
2010: Yangu Zhao; Christina M Mailloux; Edit Hermesz; Miklos Palkóvits; Heiner Westphal
A role of the LIM-homeobox gene Lhx2 in the regulation of pituitary development.
Developmental biology 2010;337(2):313-23.
2009: Wen-Tao Peng; Chi-Jiunn Pan; Eric J Lee; Heiner Westphal; Janice Y Chou
Generation of mice with a conditional allele for G6pc.
Genesis (New York, N.Y. : 2000) 2009;47(9):590-4.
2009: Itai Tzchori; Timothy F Day; Peter J Carolan; Yangu Zhao; Christopher A Wassif; Liqi Li; Mark Lewandoski; Marat Gorivodsky; Paul E Love; Forbes D Porter; Heiner Westphal; Yingzi Yang
LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth.
Development (Cambridge, England) 2009;136(8):1375-85.
2009: Cristina Bäckman; Yajun Zhang; Nasir Malik; Lufei Shan; Barry Hoffer; Heiner Westphal; Andreas C Tomac
Generalized tetracycline induced Cre recombinase expression through the ROSA26 locus of recombinant mice.
Journal of neuroscience methods 2009;176(1):16-23.
2009: Ipsita Dey-Guha; Mahua Mukhopadhyay; Matthew Phillips; Heiner Westphal
Role of ldb1 in adult intestinal homeostasis.
International journal of biological sciences 2009;5(7):686-94.
2009: Marat Gorivodsky; Mahua Mukhopadhyay; Michaela Wilsch-Braeuninger; Matthew Phillips; Andreas Teufel; Changmee Kim; Nasir Malik; Wieland Huttner; Heiner Westphal
Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain.
Developmental biology 2009;325(1):24-32.
2008: Yangu Zhao; Pierre Flandin; Jason E Long; Melissa Dela Cuesta; Heiner Westphal; John L R Rubenstein
Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants.
The Journal of comparative neurology 2008;510(1):79-99.
2008: Kristina Ellwanger; Hiroaki Saito; Philippe Clément-Lacroix; Nicole Maltry; Joachim Niedermeyer; Woon Kyu Lee; Roland Baron; Georges Rawadi; Heiner Westphal; Christof Niehrs
Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density.
Molecular and cellular biology 2008;28(15):4875-82.
2008: Minyoung Hwang; Marat Gorivodsky; Minjung Kim; Heiner Westphal; Dongho Geum
The neuronal differentiation potential of Ldb1-null mutant embryonic stem cells is dependent on extrinsic influences.
Stem cells (Dayton, Ohio) 2008;26(6):1490-5.
2008: Ipsita Dey-Guha; Nasir Malik; Renaud Lesourne; Paul E Love; Heiner Westphal
Tyrosine phosphorylation controls nuclear localization and transcriptional activity of Ssdp1 in mammalian cells.
Journal of cellular biochemistry 2008;103(6):1856-65.
2007: Yangu Zhao; Kin-Ming Kwan; Christina M Mailloux; Woon Kyu Lee; Alexander Grinberg; Wolfgang Wurst; Richard R Behringer; Heiner Westphal
LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):13182-6.
2007: Yuk Yin Cheung; So Youn Kim; Wai Han Yiu; Chi-Jiunn Pan; Hyun-Sik Jun; Robert A Ruef; Eric J Lee; Heiner Westphal; Brian C Mansfield; Janice Yang Chou
Impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking glucose-6-phosphatase-beta.
The Journal of clinical investigation 2007;117(3):784-93.
2006: Irina Leaf; Jason Tennessen; Mahua Mukhopadhyay; Heiner Westphal; William Shawlot
Sfrp5 is not essential for axis formation in the mouse.
Genesis (New York, N.Y. : 2000) 2006;44(12):573-8.
2006: Cristina Bäckman; Nasir Malik; Yajun Zhang; Lufei Shan; Alexander Grinberg; Barry Hoffer; Heiner Westphal; Andreas C Tomac
Characterization of a mouse strain expressing Cre recombinase from the 3' untranslated region of the dopamine transporter locus.
Genesis (New York, N.Y. : 2000) 2006;44(8):383-90.
2006: Yangu Zhao; Donna Chelle Morales; Edit Hermesz; Woon Kyu Lee; Samuel L Pfaff; Heiner Westphal
Reduced expression of the LIM-homeobox gene Lhx3 impairs growth and differentiation of Rathke's pouch and increases cell apoptosis during mouse pituitary development.
Mechanisms of development 2006;123(8):605-13.
2006: Mahua Mukhopadhyay; Marat Gorivodsky; Svetlana Shtrom; Alexander Grinberg; Christof Niehrs; Maria I Morasso; Heiner Westphal
Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium.
Development (Cambridge, England) 2006;133(11):2149-54.
2006: Tomoshige Kino; Emmanuil Souvatzoglou; Evangelia Charmandari; Takamasa Ichijo; Paul H Driggers; Chantal Mayers; Anton Alatsatianos; Irini Manoli; Heiner Westphal; George Chrousos; James H Segars
Rho family Guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system.
The Journal of biological chemistry 2006;281(14):9118-26.
2006: Woon Kyu Lee; Yong-Man Kim; Nasir Malik; Chang Ma; Heiner Westphal
Cloning and characterization of the 5'-flanking region of the Ehox gene.
Biochemical and biophysical research communications 2006;341(1):225-31.
2006: Ivan del Barco Barrantes; Ana Montero-Pedrazuela; Ana Guadaño-Ferraz; Maria Jesus Obregón; Raquel Martinez de Mena; Valérie Gailus-Durner; Helmut Fuchs; Tobias J Franz; Svetoslav Kalaydjiev; Martina Klempt; Sabine Hölter; Birgit Rathkolb; Claudia Reinhard; Gabriella Morreale de Escobar; Juan Bernal; Dirk H Busch; Wolfgang Wurst; Eckhard Wolf; Holger Schulz; Svetlana Shtrom; Erich Greiner; Martin Hrabé De Angelis; Heiner Westphal; Christof Niehrs
Generation and characterization of dickkopf3 mutant mice.
Molecular and cellular biology 2006;26(6):2317-26.
2005: Heiner Westphal
Restoring stemness.
Differentiation; research in biological diversity 2005;73(9-10):447-51.
2005: Noriyuki Nishioka; Seiichi Nagano; Rika Nakayama; Hiroshi Kiyonari; Takashi Ijiri; Kenichiro Taniguchi; William Shawlot; Yoshihide Hayashizaki; Heiner Westphal; Richard R Behringer; Yoichi Matsuda; Saburo Sakoda; Hisato Kondoh; Hiroshi Sasaki
Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.
Development (Cambridge, England) 2005;132(11):2535-46.
2004: Klaus B Piontek; David L Huso; Alexander Grinberg; Lijuan Liu; Djahida Bedja; Haidan Zhao; Kathleen L Gabrielson; Feng Qian; Changlin Mei; Heiner Westphal; Gregory G Germino
A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo.
Journal of the American Society of Nephrology : JASN 2004;15(12):3035-43.
2003: Toshinobu Miyamoto; Shiga Hasuike; Leah Yogev; Maria Rosa Maduro; Mutsuo Ishikawa; Heiner Westphal; Dolores J Lamb
Azoospermia in patients heterozygous for a mutation in SYCP3.
Lancet 2003;362(9397):1714-9.
2003: Li-Yuan Chen; Jeng-Jer Shieh; Baochuan Lin; Chi-Jiunn Pan; Ji-Liang Gao; Philip M Murphy; Thomas F Roe; Shimon Moses; Jerrold M Ward; Eric J Lee; Heiner Westphal; Brian C Mansfield; Janice Yang Chou
Impaired glucose homeostasis, neutrophil trafficking and function in mice lacking the glucose-6-phosphate transporter.
Human molecular genetics 2003;12(19):2547-58.
2003: Ivan del Barco Barrantes; Gary Davidson; Hermann-Josef Gröne; Heiner Westphal; Christof Niehrs
Dkk1 and noggin cooperate in mammalian head induction.
Genes & development 2003;17(18):2239-44.
2003: Yangu Zhao; Oscar Marín; Edit Hermesz; Aaron Powell; Nuria Flames; Miklós Palkovits; John L R Rubenstein; Heiner Westphal
The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):9005-10.
2003: Andreas Teufel; Eric A Wong; Mahua Mukhopadhyay; Nasir Malik; Heiner Westphal
FoxP4, a novel forkhead transcription factor.
Biochimica et biophysica acta 2003;1627(2-3):147-52.
2003: Mahua Mukhopadhyay; Andreas Teufel; Tsuyoshi Yamashita; Alan D Agulnick; Lan Chen; Karen M Downs; Alice Schindler; Alexander Grinberg; Sing-Ping Huang; David Dorward; Heiner Westphal
Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation.
Development (Cambridge, England) 2003;130(3):495-505.
2002: Heiner Westphal
Genes that fashion the pituitary gland.
Molecular and cellular endocrinology 2002;197(1-2):45-6.
2002: Lan Chen; Daniel Segal; Neil A Hukriede; Alexandre Podtelejnikov; Dashzeveg Bayarsaihan; James A Kennison; Vasily Ogryzko; Igor B Dawid; Heiner Westphal
Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14320-5.
2002: Heiner Westphal
International stem cell research considerations.
Comptes rendus biologies 2002;325(10):1045-8.
2002: Andreas Teufel; Nasir Malik; Mahua Mukhopadhyay; Heiner Westphal
Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes.
Gene 2002;297(1-2):79-83.
2002: Toshinobu Miyamoto; Maria T Fiorenza; Yangu Zhao; Shiga Hasuike; Heiner Westphal
Molecular cloning and expression analysis of MPP alpha-2, a novel mouse transcript detected in a differential screen of pituitary libraries.
Biochimica et biophysica acta 2002;1577(1):109-12.
2002: Andreas C Tomac; Alan D Agulnick; Norman Haughey; Chen-Fu Chang; Yajun Zhang; Cristina Bäckman; Marisela Morales; Mark P Mattson; Yun Wang; Heiner Westphal; Barry Hoffer
Effects of cerebral ischemia in mice deficient in Persephin.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9521-6.
2002: Toshinobu Miyamoto; Atsuo Kawahara; Andreas Teufel; Mahua Mukhopadhyay; Yangu Zhao; Igor B Dawid; Heiner Westphal
Mbx, a novel mouse homeobox gene.
Development genes and evolution 2002;212(2):104-6.
2002: Yangu Zhao; Heiner Westphal
Homeobox genes and human genetic disorders.
Current molecular medicine 2002;2(1):13-23.
2002: Liya Shen; José G Pichel; Thomas Mayeli; Hannu Sariola; Bai Lu; Heiner Westphal
Gdnf haploinsufficiency causes Hirschsprung-like intestinal obstruction and early-onset lethality in mice.
American journal of human genetics 2002;70(2):435-47.
2001: M T Fiorenza; Mahua Mukhopadhyay; Heiner Westphal
Expression screening for Lhx3 downstream genes identifies Thg-1pit as a novel mouse gene involved in pituitary development.
Gene 2001;278(1-2):125-30.
2001: Mahua Mukhopadhyay; Svetlana Shtrom; Concepcion Rodriguez-Esteban; Lan Chen; T Tsukui; L Gomer; D W Dorward; Andrei Glinka; Alexander Grinberg; Sing-Ping Huang; Christof Niehrs; J C Izpisúa Belmonte; Heiner Westphal
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse.
Developmental cell 2001;1(3):423-34.
2000: Yangu Zhao; Edit Hermesz; M C Yarolin; Heiner Westphal
Genomic structure, chromosomal localization and expression of the human LIM-homeobox gene LHX5.
Gene 2000;260(1-2):95-101.
2000: Catherine M Farrell; Alexander Grinberg; S P Huang; Daofen Chen; José G Pichel; Heiner Westphal; Gary Felsenfeld
A large upstream region is not necessary for gene expression or hypersensitive site formation at the mouse beta -globin locus.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14554-9.
2000: T Yamauchi; J Yamauchi; T Kuwata; Tomohiko Tamura; T Yamashita; Nancy S Bae; Heiner Westphal; Keiko Ozato; Yoshihiro Nakatani
Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11303-6.
2000: JH Pak; Freesia L Huang; Junfa Li; Detlef Balschun; Klaus G Reymann; Chin Chiang; Heiner Westphal; Kuo-Ping Huang
Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: a study with knockout mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11232-7.
2000: Ann-Charlotte E. Granholm-Bentley; Mary E Reyland; David S Albeck; L Sanders; Greg A Gerhardt; GR Hoernig; Liya Shen; Heiner Westphal; Barry Hoffer
Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(9):3182-90.
2000: Xiaojuan Meng; Maria Lindahl; M E Hyvönen; Martti Parvinen; D G de Rooij; M W Hess; AM Raatikainen-Ahokas; Kirsi Sainio; Heikki Rauvala; Merja Lakso; José G Pichel; Heiner Westphal; Mart Saarma; Hannu Sariola
Regulation of cell fate decision of undifferentiated spermatogonia by GDNF.
Science (New York, N.Y.) 2000;287(5457):1489-93.
2000: Ohad Birk; D E Casiano; Christopher A Wassif; T Cogliati; L Zhao; Yangu Zhao; Alexander Grinberg; S Huang; J A Kreidberg; K L Parker; Forbes D Porter; Heiner Westphal
The LIM homeobox gene Lhx9 is essential for mouse gonad formation.
Nature 2000;403(6772):909-13.
2000: Zhongjian Zhang; GC Kundu; F Zheng; Chiun-Jye Yuan; E Lee; Heiner Westphal; J Ward; F DeMayo; Anil B Mukherjee
Insight into the physiological function(s) of uteroglobin by gene-knockout and antisense-transgenic approaches.
Annals of the New York Academy of Sciences 2000;923():210-33.
2000: Andreas C Tomac; Alexander Grinberg; S P Huang; Christopher A Nosrat; Yumei Wang; Cesario Borlongan; S Z Lin; Yung-Hsiao Chiang; Lars Olson; Heiner Westphal; Barry Hoffer
Glial cell line-derived neurotrophic factor receptor alpha1 availability regulates glial cell line-derived neurotrophic factor signaling: evidence from mice carrying one or two mutated alleles.
Neuroscience 2000;95(4):1011-23.
1999: Antonella Forlino; Forbes D Porter; E J Lee; Heiner Westphal; Joan C Marini
Use of the Cre/lox recombination system to develop a non-lethal knock-in murine model for osteogenesis imperfecta with an alpha1(I) G349C substitution. Variability in phenotype in BrtlIV mice.
The Journal of biological chemistry 1999;274(53):37923-31.
1999: Yangu Zhao; Y J Guo; Andreas C Tomac; N R Taylor; Alexander Grinberg; E J Lee; S Huang; Heiner Westphal
Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15002-6.
1999: Meera Srivastava; Illani Atwater; Mirta Glasman; Ximena Leighton; Gertrud Goping; Hung Caohuy; G Miller; José G Pichel; Heiner Westphal; David Mears; Eduardo Rojas; Harvey B Pollard
Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouse.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(24):13783-8.
1999: HZ Sheng; Heiner Westphal
Early steps in pituitary organogenesis.
Trends in genetics : TIG 1999;15(6):236-40.
1999: Yangu Zhao; HZ Sheng; R Amini; Alexander Grinberg; E Lee; S Huang; Masanori Taira; Heiner Westphal
Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5.
Science (New York, N.Y.) 1999;284(5417):1155-8.
1999: S Bertuzzi; Forbes D Porter; A Pitts; M Kumar; Alan D Agulnick; Christopher A Wassif; Heiner Westphal
Characterization of Lhx9, a novel LIM/homeobox gene expressed by the pioneer neurons in the mouse cerebral cortex.
Mechanisms of development 1999;81(1-2):193-8.
1999: Ying Litingtung; Ann M Lawler; Suzanne M Sebald; E Lee; John D Gearhart; Heiner Westphal; Jeffry L Corden
Growth retardation and neonatal lethality in mice with a homozygous deletion in the C-terminal domain of RNA polymerase II.
Molecular & general genetics : MGG 1999;261(1):100-5.
1999: Chin Chiang; R Z Swan; Marina Grachtchouk; M Bolinger; Ying Litingtung; E K Robertson; Michael K Cooper; W Gaffield; Heiner Westphal; Philip A Beachy; Andrzej Dlugosz
Essential role for Sonic hedgehog during hair follicle morphogenesis.
Developmental biology 1999;205(1):1-9.
1998: N Takuma; HZ Sheng; Y Furuta; J M Ward; K Sharma; B L Hogan; Samuel L Pfaff; Heiner Westphal; S Kimura; Kathleen A Mahon
Formation of Rathke's pouch requires dual induction from the diencephalon.
Development (Cambridge, England) 1998;125(23):4835-40.
1998: Ying Litingtung; L Lei; Heiner Westphal; Chin Chiang
Sonic hedgehog is essential to foregut development.
Nature genetics 1998;20(1):58-61.
1998: J J Breen; Alan D Agulnick; Heiner Westphal; Igor B Dawid
Interactions between LIM domains and the LIM domain-binding protein Ldb1.
The Journal of biological chemistry 1998;273(8):4712-7.
1998: T Yamashita; Alan D Agulnick; N G Copeland; D J Gilbert; N A Jenkins; Heiner Westphal
Genomic structure and chromosomal localization of the mouse LIM domain-binding protein 1 gene, Ldb1.
Genomics 1998;48(1):87-92.
1997: HZ Sheng; K Moriyama; T Yamashita; H Li; steven potter; Kathleen A Mahon; Heiner Westphal
Multistep control of pituitary organogenesis.
Science (New York, N.Y.) 1997;278(5344):1809-12.
1997: AN Tullio; D Accili; Victor J Ferrans; Zu-Xi Yu; Kazuyo Takeda; Alexander Grinberg; Heiner Westphal; Yvette A Preston; Robert S Adelstein
Nonmuscle myosin II-B is required for normal development of the mouse heart.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(23):12407-12.
1997: Johan Widenfalk; Christopher A Nosrat; Andreas C Tomac; Heiner Westphal; Barry Hoffer; Lars Olson
Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(21):8506-19.
1997: JR Gnarra; Jerrold M Ward; F D Porter; J R Wagner; D E Devor; Alexander Grinberg; Michael R Emmert-Buck; Heiner Westphal; Richard D Klausner; W Marston Linehan
Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9102-7.
1997: T Yamashita; K Moriyama; HZ Sheng; Heiner Westphal
Lhx4, a LIM homeobox gene.
Genomics 1997;44(1):144-6.
1997: Forbes D Porter; John Drago; Y Xu; S S Cheema; Christopher A Wassif; S P Huang; E Lee; Alexander Grinberg; Jim S Massalas; David M Bodine; F Alt; Heiner Westphal
Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development.
Development (Cambridge, England) 1997;124(15):2935-44.
1997: Ji-Liang Gao; Thomas A Wynn; Y Chang; E J Lee; H E Broxmeyer; S Cooper; HL Tiffany; Heiner Westphal; J Kwon-Chung; Philip M Murphy
Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1.
The Journal of experimental medicine 1997;185(11):1959-68.
1997: Zhongjian Zhang; GC Kundu; Chiun-Jye Yuan; J M Ward; E J Lee; F DeMayo; Heiner Westphal; Anil B Mukherjee
Severe fibronectin-deposit renal glomerular disease in mice lacking uteroglobin.
Science (New York, N.Y.) 1997;276(5317):1408-12.
1997: D J Good; F D Porter; Kathleen A Mahon; A F Parlow; Heiner Westphal; Ilan R Kirsch
Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene.
Nature genetics 1997;15(4):397-401.
1997: HZ Sheng; S Bertuzzi; Chin Chiang; William Shawlot; Masanori Taira; Igor B Dawid; Heiner Westphal
Expression of murine Lhx5 suggests a role in specifying the forebrain.
Developmental dynamics : an official publication of the American Association of Anatomists 1997;208(2):266-77.
1997: Ann-Charlotte E. Granholm-Bentley; N Srivastava; J L Mott; S Henry; Michael Henry; Heiner Westphal; José G Pichel; Liya Shen; Barry Hoffer
Morphological alterations in the peripheral and central nervous systems of mice lacking glial cell line-derived neurotrophic factor (GDNF): immunohistochemical studies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(3):1168-78.
1996: Alan D Agulnick; Masanori Taira; J J Breen; T Tanaka; Igor B Dawid; Heiner Westphal
Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins.
Nature 1996;384(6606):270-2.
1996: Chin Chiang; Ying Litingtung; E Lee; Keith E Young; Jeffry L Corden; Heiner Westphal; Philip A Beachy
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
Nature 1996;383(6599):407-13.
1996: John Drago; Charles R Gerfen; Heiner Westphal; H Steiner
D1 dopamine receptor-deficient mouse: cocaine-induced regulation of immediate-early gene and substance P expression in the striatum.
Neuroscience 1996;74(3):813-23.
1996: S Bertuzzi; HZ Sheng; N G Copeland; D J Gilbert; N A Jenkins; Masanori Taira; Igor B Dawid; Heiner Westphal
Molecular cloning, structure, and chromosomal localization of the mouse LIM/homeobox gene Lhx5.
Genomics 1996;36(2):234-9.
1996: Tracy L Rankin; M Familari; Eric Lee; A Ginsberg; Nancy K Dwyer; J Blanchette-Mackie; John Drago; Heiner Westphal; Jurrien Dean
Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile.
Development (Cambridge, England) 1996;122(9):2903-10.
1996: J G Pichel; L Shen; HZ Sheng; Ann-Charlotte E. Granholm-Bentley; John Drago; Alexander Grinberg; E J Lee; S P Huang; M Saarma; Barry Hoffer; H Sariola; Heiner Westphal
Defects in enteric innervation and kidney development in mice lacking GDNF.
Nature 1996;382(6586):73-6.
1996: M Lakso; J G Pichel; J R Gorman; B Sauer; Y Okamoto; E Lee; F W Alt; Heiner Westphal
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):5860-5.
1996: KJ Lei; H Chen; Chi-Jiunn Pan; J M Ward; B Mosinger; E J Lee; Heiner Westphal; B C Mansfield; Janice Yang Chou
Glucose-6-phosphatase dependent substrate transport in the glycogen storage disease type-1a mouse.
Nature genetics 1996;13(2):203-9.
1996: HZ Sheng; A B Zhadanov; B Mosinger; T Fujii; S Bertuzzi; Alexander Grinberg; E J Lee; S P Huang; Kathleen A Mahon; Heiner Westphal
Specification of pituitary cell lineages by the LIM homeobox gene Lhx3.
Science (New York, N.Y.) 1996;272(5264):1004-7.
1996: D Accili; C Simone Fishburn; John Drago; H Steiner; J E Lachowicz; B H Park; Estelle B Gauda; E J Lee; M H Cool; David R Sibley; Charles R Gerfen; Heiner Westphal; Sara Fuchs
A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(5):1945-9.
1996: J G Pichel; L Shen; HZ Sheng; Ann-Charlotte E. Granholm-Bentley; John Drago; Alexander Grinberg; E J Lee; S P Huang; M Saarma; Barry Hoffer; H Sariola; Heiner Westphal
GDNF is required for kidney development and enteric innervation.
Cold Spring Harbor symposia on quantitative biology 1996;61():445-57.
1996: D Accili; John Drago; E J Lee; M D Johnson; M H Cool; P Salvatore; Laureano Asico; P A José; Simeon I Taylor; Heiner Westphal
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene.
Nature genetics 1996;12(1):106-9.
1995: K Sango; S Yamanaka; A Hoffmann; Y Okuda; A Grinberg; Heiner Westphal; MP McDonald; Jacqueline N Crawley; Konrad Sandhoff; Kinuko Suzuki; Richard L Proia
Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism.
Nature genetics 1995;11(2):170-6.
1995: T Nakamura; J G Pichel; L Williams-Simons; Heiner Westphal
An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):6142-6.
1995: S S Lee; Thierry Pineau; J Drago; E J Lee; J W Owens; Deanna L Kroetz; Pedro Fernandez-Salguero; Heiner Westphal; Frank J Gonzalez
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.
Molecular and cellular biology 1995;15(6):3012-22.
1995: Marc L Reitman; E Lee; Heiner Westphal
Function of the upstream hypersensitive sites of the chicken beta-globin gene cluster in mice.
Nucleic acids research 1995;23(10):1790-4.
1995: A B Zhadanov; N G Copeland; D J Gilbert; N A Jenkins; Heiner Westphal
Genomic structure and chromosomal localization of the mouse LIM/homeobox gene Lhx3.
Genomics 1995;27(1):27-32.
1995: A B Zhadanov; S Bertuzzi; Masanori Taira; Igor B Dawid; Heiner Westphal
Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues.
Developmental dynamics : an official publication of the American Association of Anatomists 1995;202(4):354-64.
1995: MM Mason; E Lee; Heiner Westphal; Marc L Reitman
Expression of the chicken beta-globin gene cluster in mice: correct developmental expression and distributed control.
Molecular and cellular biology 1995;15(1):407-14.
1994: S Yamanaka; M D Johnson; A Grinberg; Heiner Westphal; Jacqueline N Crawley; Masako Taniike; Kinuko Suzuki; Richard L Proia
Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):9975-9.
1994: U Tillmann; J Wagner; D Boerboom; Heiner Westphal; Michel L Tremblay
Nuclear localization and cell cycle regulation of a murine protein tyrosine phosphatase.
Molecular and cellular biology 1994;14(5):3030-40.
1994: Paul E Love; Elizabeth W Shores; E J Lee; Alexander Grinberg; T I Munitz; Heiner Westphal; Alfred Singer
Differential effects of zeta and eta transgenes on early alpha/beta T cell development.
The Journal of experimental medicine 1994;179(5):1485-94.
1994: T Fujii; J G Pichel; Masanori Taira; Reiko Toyama; Igor B Dawid; Heiner Westphal
Expression patterns of the murine LIM class homeobox gene lim1 in the developing brain and excretory system.
Developmental dynamics : an official publication of the American Association of Anatomists 1994;199(1):73-83.
1994: Heiner Westphal
Lens oncogenesis and differentiation.
Genetic engineering 1994;16():11-6.
1993: J G Pichel; M Lakso; Heiner Westphal
Timing of SV40 oncogene activation by site-specific recombination determines subsequent tumor progression during murine lens development.
Oncogene 1993;8(12):3333-42.
1993: Paul E Love; Elizabeth W Shores; M D Johnson; Michel L Tremblay; E J Lee; Alexander Grinberg; S P Huang; Alfred Singer; Heiner Westphal
T cell development in mice that lack the zeta chain of the T cell antigen receptor complex.
Science (New York, N.Y.) 1993;261(5123):918-21.
1993: Marc L Reitman; E Lee; Heiner Westphal; Gary Felsenfeld
An enhancer/locus control region is not sufficient to open chromatin.
Molecular and cellular biology 1993;13(7):3990-8.
1993: Gregory R Dressler; John Wilkinson; Uwe Rothenpieler; L T Patterson; L Williams-Simons; Heiner Westphal
Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities.
Nature 1993;362(6415):65-7.
1993: D Clark; M Reitman; Vasily M Studitsky; J Chung; Heiner Westphal; E Lee; Gary Felsenfeld
Chromatin structure of transcriptionally active genes.
Cold Spring Harbor symposia on quantitative biology 1993;58():1-6.
1992: M Lakso; P S Steeg; Heiner Westphal
Embryonic expression of nm23 during mouse organogenesis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992;3(12):873-9.
1992: Paul E Love; Michel L Tremblay; Heiner Westphal
Targeting of the T-cell receptor zeta-chain gene in embryonic stem cells: strategies for generating multiple mutations in a single gene.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9929-33.
1992: M Lakso; B Sauer; B Mosinger; E J Lee; R W Manning; S H Yu; K L Mulder; Heiner Westphal
Targeted oncogene activation by site-specific recombination in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6232-6.
1992: B Mosinger; U Tillmann; Heiner Westphal; Michel L Tremblay
Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(2):499-503.
1992: E M Füchtbauer; Heiner Westphal
MyoD and myogenin are coexpressed in regenerating skeletal muscle of the mouse.
Developmental dynamics : an official publication of the American Association of Anatomists 1992;193(1):34-9.
1990: Marc L Reitman; E Lee; Heiner Westphal; Gary Felsenfeld
Site-independent expression of the chicken beta A-globin gene in transgenic mice.
Nature 1990;348(6303):749-52.
1990: F Propst; M P Rosenberg; L C Cork; R M Kovatch; S Rauch; Heiner Westphal; J Khillan; N T Schulz; P E Neumann; George Vande Woude; P E Newmann
Neuropathological changes in transgenic mice carrying copies of a transcriptionally activated Mos protooncogene.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9703-7.
1990: T Nakamura; D M Donovan; K Hamada; CM Sax; B Norman; James R Flanagan; Keiko Ozato; Heiner Westphal; Joram Piatigorsky
Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes.
Molecular and cellular biology 1990;10(7):3700-8.
1989: T Nakamura; Kathleen A Mahon; R Miskin; A Dey; T Kuwabara; Heiner Westphal
Differentiation and oncogenesis: phenotypically distinct lens tumors in transgenic mice.
The New biologist 1989;1(2):193-204.
1989: A Dey; Heiner Westphal; Daniel W Nebert
Cell-specific induction of mouse Cyp1a1 mRNA during development.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7446-50.
1989: J Leonard; J S Khillan; Howard Gendelman; A Adachi; S Lorenzo; Heiner Westphal; Malcolm Martin; M S Meltzer
The human immunodeficiency virus long terminal repeat is preferentially expressed in Langerhans cells in transgenic mice.
AIDS research and human retroviruses 1989;5(4):421-30.
1989: S H Yu; K C Deen; E Lee; L Hennighausen; Raymond W Sweet; M Rosenberg; Heiner Westphal
Functional human CD4 protein produced in milk of transgenic mice.
Molecular biology & medicine 1989;6(4):255-61.
1989: A E Griep; T Kuwabara; E J Lee; Heiner Westphal
Perturbed development of the mouse lens by polyomavirus large T antigen does not lead to tumor formation.
Genes & development 1989;3(7):1075-85.
1989: Heiner Westphal; P Gruss
Molecular genetics of development studied in the transgenic mouse.
Annual review of cell biology 1989;5():181-96.
1988: Heiner Westphal
Perturbations of lens development in the transgenic mouse.
Cell differentiation and development : the official journal of the International Society of Developmental Biologists 1988;25 Suppl():33-7.
1988: B Krippl; A E Griep; Kathleen A Mahon; E Böhnlein; P Gruss; Heiner Westphal
Expression and amplification in transgenic mice of a polyoma virus mutant regulatory region.
Nucleic acids research 1988;16(18):8963-76.
1988: A E Griep; Heiner Westphal
Antisense Myc sequences induce differentiation of F9 cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6806-10.
1988: C W Pittius; Lothar Hennighausen; E Lee; Heiner Westphal; E Nicols; J Vitale; K Gordon
A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):5874-8.
1988: J S Khillan; K C Deen; S H Yu; Raymond W Sweet; M Rosenberg; Heiner Westphal
Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice.
Nucleic acids research 1988;16(4):1423-30.
1988: Kathleen A Mahon; P A Overbeek; Heiner Westphal
Prenatal lethality in a transgenic mouse line is the result of a chromosomal translocation.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(4):1165-8.
1988: Kathleen A Mahon; Heiner Westphal; P Gruss
Expression of homeobox gene Hox 1.1 during mouse embryogenesis.
Development (Cambridge, England) 1988;104 Suppl():187-95.
1987: J S Khillan; M K Oskarsson; F Propst; T Kuwabara; George Vande Woude; Heiner Westphal
Defects in lens fiber differentiation are linked to c-mos overexpression in transgenic mice.
Genes & development 1987;1(10):1327-35.
1987: Ana B Chepelinsky; J S Khillan; Kathleen A Mahon; P A Overbeek; Heiner Westphal; J Piatigorsky
Crystallin genes: lens specificity of the murine alpha A-crystallin gene.
Environmental health perspectives 1987;75():17-24.
1987: Kathleen A Mahon; Ana B Chepelinsky; J S Khillan; P A Overbeek; J Piatigorsky; Heiner Westphal
Oncogenesis of the lens in transgenic mice.
Science (New York, N.Y.) 1987;235(4796):1622-8.
1986: J S Khillan; A Schmidt; P A Overbeek; B de Crombrugghe; Heiner Westphal
Developmental and tissue-specific expression directed by the alpha 2 type I collagen promoter in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(3):725-9.
1985: P A Overbeek; Ana B Chepelinsky; J S Khillan; J Piatigorsky; Heiner Westphal
Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(23):7815-9.
1985: J S Khillan; P A Overbeek; Heiner Westphal
Drosophila P element integration in the mouse.
Developmental biology 1985;109(1):247-50.
1985: Heiner Westphal; P A Overbeek; J S Khillan; Ana B Chepelinsky; A Schmidt; Kathleen A Mahon; K E Bernstein; J Piatigorsky; B de Crombrugghe
Promoter sequences of murine alpha A crystallin, murine alpha 2(I) collagen or of avian sarcoma virus genes linked to the bacterial chloramphenicol acetyl transferase gene direct tissue-specific patterns of chloramphenicol acetyl transferase expression in transgenic mice.
Cold Spring Harbor symposia on quantitative biology 1985;50():411-6.