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Michael Wheeler

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Emma M Allister; Herbert Y Gaisano; Patrick Gilon; Alexandre B Hardy; Pedro L Herrera; Dong Kong; Bradford B Lowell; Kacey J Prentice; Christine A Robson-Doucette; Sobia Sultan; Michael B Wheeler
UCP2 regulates the glucagon response to fasting and starvation.
Stephanie Tung; Michael B Wheeler; Alexandre B Hardy; Denise D Belsham
Serotonin (5-HT) activation of immortalized hypothalamic neuronal cells through the 5-HT1B serotonin receptor.
Dan Zhu; Emma M Allister; Erica P Cai; Diana Choi; Subhankar Dolai; Wan-Jin Hong; Youhou Kang; Patrick P L Lam; Yunfeng Liu; Tairan Qin; Stephanie A Schroer; Cheng-Chun Wang; Michael B Wheeler; Minna Woo; Yi Zhang; Herbert Y Gaisano
Dual role of VAMP8 in regulating insulin exocytosis and islet β cell growth.

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2013: Emma M Allister; Herbert Y Gaisano; Patrick Gilon; Alexandre B Hardy; Pedro L Herrera; Dong Kong; Bradford B Lowell; Kacey J Prentice; Christine A Robson-Doucette; Sobia Sultan; Michael B Wheeler
UCP2 regulates the glucagon response to fasting and starvation.
Diabetes 2013;62(5):1623-33.
2012: Stephanie Tung; Michael B Wheeler; Alexandre B Hardy; Denise D Belsham
Serotonin (5-HT) activation of immortalized hypothalamic neuronal cells through the 5-HT1B serotonin receptor.
Endocrinology 2012;153(10):4862-73.
2012: Dan Zhu; Emma M Allister; Erica P Cai; Diana Choi; Subhankar Dolai; Wan-Jin Hong; Youhou Kang; Patrick P L Lam; Yunfeng Liu; Tairan Qin; Stephanie A Schroer; Cheng-Chun Wang; Michael B Wheeler; Minna Woo; Yi Zhang; Herbert Y Gaisano
Dual role of VAMP8 in regulating insulin exocytosis and islet β cell growth.
Cell metabolism 2012;16(2):238-49.
2012: A B Hardy; D Kong; K J Prentice; A Bhattacharjee; Fabrice CHIMIENTI; I Genkin; Nadeeja Wijesekara; Michael B Wheeler
Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8.
American journal of physiology. Endocrinology and metabolism 2012;302(9):E1084-96.
2012: Alpana Bhattacharjee; Emma M Allister; Michael B Wheeler
MK-626, a dipeptidyl peptidase-4 inhibitor, does not improve the hyperglycemia or hyperinsulinemia of nonobese diabetic MKR mice.
Canadian journal of physiology and pharmacology 2012;90(5):663-8.
2012: C Tang; Allen Volchuk; P Wang; Michael B Wheeler; L Zhang; A Ivovic; K Koulajian; B Minassian; C Robson-Doucette; I Schuiki; T Desai; A Giacca
Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress.
Diabetologia 2012;55(5):1366-79.
2011: A B Hardy; A S Serino; Fabrice CHIMIENTI; Nadeeja Wijesekara; Michael B Wheeler
Regulation of glucagon secretion by zinc: lessons from the β cell-specific Znt8 knockout mouse model.
Diabetes, obesity & metabolism 2011;13 Suppl 1():112-7.
2011: Rodolfo Niño Fong; Zahra Fatehi-Hassanabad; Simon C Lee; Hongfang Lu; Michael B Wheeler; Catherine B Chan
Uncoupling protein-2 increases nitric oxide production and TNFAIP3 pathway activation in pancreatic islets.
Journal of molecular endocrinology 2011;46(3):193-204.
2011: Simon R Smukler; Margot E Arntfield; Rozita Razavi; George Bikopoulos; Phillip Karpowicz; Raewyn Seaberg; Feihan Dai; Simon Lee; Rosemary Ahrens; Paul E Fraser; Michael B Wheeler; Derek van der Kooy
The adult mouse and human pancreas contain rare multipotent stem cells that express insulin.
Cell stem cell 2011;8(3):281-93.
2011: M Cristina Nostro; Farida Sarangi; Shinichiro Ogawa; Audrey Holtzinger; Barbara Corneo; Xueling Li; Suzanne J Micallef; In-Hyun Park; Christina Basford; Michael B Wheeler; George Q Daley; Andrew G Elefanty; Edouard G Stanley; Gordon Keller
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells.
Development (Cambridge, England) 2011;138(5):861-71.
2010: Nadeeja Wijesekara; Mansa Krishnamurthy; Alpana Bhattacharjee; Aamir Suhail; Gary Sweeney; Michael B Wheeler
Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion.
The Journal of biological chemistry 2010;285(44):33623-31.
2010: Nadeeja Wijesekara; Feihan F Dai; A B Hardy; P R Giglou; A Bhattacharjee; Vasilij Koshkin; Fabrice CHIMIENTI; Herbert Y Gaisano; G A Rutter; Michael B Wheeler
Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.
Diabetologia 2010;53(8):1656-68.
2010: Masoud Shabani Domola; Vivian Vu; Christine A Robson-Doucette; Gary Sweeney; Michael B Wheeler
Insulin mimetics in Urtica dioica: structural and computational analyses of Urtica dioica extracts.
Phytotherapy research : PTR 2010;24 Suppl 2():S175-82.
2010: Hongfang Lu; Vasilij Koshkin; Emma M Allister; Armen V Gyulkhandanyan; Michael B Wheeler
Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes.
Diabetes 2010;59(2):448-59.
2009: Nadeeja Wijesekara; Fabrice CHIMIENTI; Michael B Wheeler
Zinc, a regulator of islet function and glucose homeostasis.
Diabetes, obesity & metabolism 2009;11 Suppl 4():202-14.
2009: Alexandre B Hardy; Jocelyn E Manning Fox; Pejman Raeisi Giglou; Nadeeja Wijesekara; Alpana Bhattacharjee; Sobia Sultan; Armen V Gyulkhandanyan; Herbert Y Gaisano; Patrick E MacDonald; Michael B Wheeler
Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets.
The Journal of biological chemistry 2009;284(44):30441-52.
2009: Accalia Fu; Andy Cheuk-Him Ng; Chantal Depatie; Nadeeja Wijesekara; Ying He; Gen-Sheng Wang; Nabeel Bardeesy; Fraser W Scott; Rhian M Touyz; Michael B Wheeler; Robert A Screaton
Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice.
Cell metabolism 2009;10(4):285-95.
2009: Yi Zhang; Yunfeng Liu; Jihong Qu; Alexandre Hardy; Nina Zhang; Jingyu Diao; Paul J Strijbos; Robert G Tsushima; Richard B Robinson; Herbert Y Gaisano; Qinghua Wang; Michael B Wheeler
Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cells.
The Journal of endocrinology 2009;203(1):45-53.
2009: Simon C Lee; Christine A Robson-Doucette; Michael B Wheeler
Uncoupling protein 2 regulates reactive oxygen species formation in islets and influences susceptibility to diabetogenic action of streptozotocin.
The Journal of endocrinology 2009;203(1):33-43.
2008: Yaou Zhang; Nina Zhang; Armen V Gyulkhandanyan; Elaine Xu; Herbert Y Gaisano; Michael B Wheeler; Qinghua Wang
Presence of functional hyperpolarisation-activated cyclic nucleotide-gated channels in clonal alpha cell lines and rat islet alpha cells.
Diabetologia 2008;51(12):2290-8.
2008: Jingyu Diao; Emma M Allister; Vasilij Koshkin; Simon C Lee; Alpana Bhattacharjee; Christine Tang; Adria Giacca; Catherine B Chan; Michael B Wheeler
UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):12057-62.
2008: Hongfang Lu; Ying Yang; Emma M Allister; Nadeeja Wijesekara; Michael B Wheeler
The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach.
Molecular & cellular proteomics : MCP 2008;7(8):1434-51.
2008: Armen V Gyulkhandanyan; Hongfang Lu; Simon C Lee; Alpana Bhattacharjee; Nadeeja Wijesekara; Jocelyn E Manning Fox; Patrick E MacDonald; Fabrice CHIMIENTI; Feihan F Dai; Michael B Wheeler
Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells.
The Journal of biological chemistry 2008;283(15):10184-97.
2008: Vasilij Koshkin; Feihan F Dai; Christine A Robson-Doucette; Catherine B Chan; Michael B Wheeler
Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic beta-cells.
The Journal of biological chemistry 2008;283(12):7936-48.
2008: Elida Lai; George Bikopoulos; Michael B Wheeler; Maria Rozakis-Adcock; Allen Volchuk
Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells.
American journal of physiology. Endocrinology and metabolism 2008;294(3):E540-50.
2007: Andrei I Oprescu; George Bikopoulos; Anthony Naassan; Emma M Allister; Christine Tang; Edward Park; Hiroshi Uchino; Gary F Lewis; I George Fantus; Maria Rozakis-Adcock; Michael B Wheeler; Adria Giacca
Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo.
Diabetes 2007;56(12):2927-37.
2007: Christine Tang; Ping Han; Andrei I Oprescu; Simon C Lee; Armen V Gyulkhandanyan; Gary N Y Chan; Michael B Wheeler; Adria Giacca
Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo.
Diabetes 2007;56(11):2722-31.
2007: Jingxin Li; Nina Zhang; Bin Ye; William Ju; B Orser; J E M Fox; Michael B Wheeler; Qinghua Wang; Wei-Yang Lu
Non-steroidal anti-inflammatory drugs increase insulin release from beta cells by inhibiting ATP-sensitive potassium channels.
British journal of pharmacology 2007;151(4):483-93.
2007: Fuzhen Xia; Yuk M Leung; Gregory Gaisano; Xiaodong Gao; Yi Chen; Jocelyn E Manning Fox; Alpana Bhattacharjee; Michael B Wheeler; Herbert Y Gaisano; Robert G Tsushima
Targeting of voltage-gated K+ and Ca2+ channels and soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins to cholesterol-rich lipid rafts in pancreatic alpha-cells: effects on glucagon stimulus-secretion coupling.
Endocrinology 2007;148(5):2157-67.
2007: Fang Cai; Armen V Gyulkhandanyan; Michael B Wheeler; Denise D Belsham
Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin.
The Journal of endocrinology 2007;192(3):605-14.
2007: Wasim El-Kholy; Patrick E MacDonald; Jocelyn Manning Fox; Alpana Bhattacharjee; Tian Xue; Xiaodong Gao; Yi Zhang; Juliane Stieber; Ronald A Li; Robert G Tsushima; Michael B Wheeler
Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells.
Molecular endocrinology (Baltimore, Md.) 2007;21(3):753-64.
2007: Hong-Fang Lu; Elisha D Targonsky; Michael B Wheeler; Yu-Ling Cheng
Thermally induced gelable polymer networks for living cell encapsulation.
Biotechnology and bioengineering 2007;96(1):146-55.
2006: Jocelyn E Manning Fox; Gunce Karaman; Michael B Wheeler
Alkali pH directly activates ATP-sensitive K+ channels and inhibits insulin secretion in beta-cells.
Biochemical and biophysical research communications 2006;350(2):492-7.
2006: Jocelyn E Manning Fox; Armen V Gyulkhandanyan; Leslie S Satin; Michael B Wheeler
Oscillatory membrane potential response to glucose in islet beta-cells: a comparison of islet-cell electrical activity in mouse and rat.
Endocrinology 2006;147(10):4655-63.
2006: Tim McQuaid; Monique C Saleh; Jamie W Joseph; Armen V Gyulkhandanyan; J E Manning-Fox; J D MacLellan; Michael B Wheeler; Catherine B Chan
cAMP-mediated signaling normalizes glucose-stimulated insulin secretion in uncoupling protein-2 overexpressing beta-cells.
The Journal of endocrinology 2006;190(3):669-80.
2006: Monique C Saleh; Michael B Wheeler; Catherine B Chan
Endogenous islet uncoupling protein-2 expression and loss of glucose homeostasis in ob/ob mice.
The Journal of endocrinology 2006;190(3):659-67.
2006: Feihan F Dai; Yi Zhang; Youhou Kang; Qinghua Wang; Herbert Y Gaisano; Karl-Heinz Braunewell; Catherine B Chan; Michael B Wheeler
The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion.
The Journal of biological chemistry 2006;281(31):21942-53.
2006: Elisha D Targonsky; Feihan F Dai; Vasilij Koshkin; G T Karaman; Armen V Gyulkhandanyan; Yi Zhang; Catherine B Chan; Michael B Wheeler
alpha-lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells.
Diabetologia 2006;49(7):1587-98.
2006: Kinh-Tung T Nguyen; Panteha Tajmir; Chia Hung Lin; Nicole Liadis; Xu-Dong Zhu; Mohamed Eweida; Gunce Tolasa-Karaman; Fang Cai; Rennian Wang; Tadahiro Kitamura; Denise D Belsham; Michael B Wheeler; Akira Suzuki; Tak W Mak; Minna Woo
Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo.
Molecular and cellular biology 2006;26(12):4511-8.
2006: Armen V Gyulkhandanyan; Simon C Lee; George Bikopoulos; Feihan F Dai; Michael B Wheeler
The Zn2+-transporting pathways in pancreatic beta-cells: a role for the L-type voltage-gated Ca2+ channel.
The Journal of biological chemistry 2006;281(14):9361-72.
2006: Elaine Xu; Mohan Kumar; Yi Zhang; William Ju; Toshiyuki Obata; Nina Zhang; Shiying Liu; Anna Wendt; Shaoping Deng; Yousuke Ebina; Michael B Wheeler; Matthias Braun; Qinghua Wang
Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system.
Cell metabolism 2006;3(1):47-58.
2006: Zeenat Asghar; Daphne Yau; F Chan; Derek LeRoith; Catherine B Chan; Michael B Wheeler
Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes.
Diabetologia 2006;49(1):90-9.
2005: Jingyu Diao; Zeenat Asghar; Catherine B Chan; Michael B Wheeler
Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells.
The Journal of biological chemistry 2005;280(39):33487-96.
2005: Yuka Toyoshima; Oksana Gavrilova; Shoshana Yakar; William Jou; Stephanie Pack; Zeenat Asghar; Michael B Wheeler; Derek LeRoith
Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes.
Endocrinology 2005;146(9):4024-35.
2004: Jamie W Joseph; Vasilij Koshkin; Monique C Saleh; William I Sivitz; Chen-Yu zhang; Bradford B Lowell; Catherine B Chan; Michael B Wheeler
Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.
The Journal of biological chemistry 2004;279(49):51049-56.
2004: Vasilij Koshkin; George Bikopoulos; Catherine B Chan; Michael B Wheeler
The characterization of mitochondrial permeability transition in clonal pancreatic beta-cells. Multiple modes and regulation.
The Journal of biological chemistry 2004;279(40):41368-76.
2004: Lisa Héron-Milhavet; Martin Haluzik; Shoshana Yakar; Oksana Gavrilova; Stephanie Pack; William Jou; Azeddine Ibrahimi; Hyunsook Kim; Desmond Hunt; Daphne Yau; Zeenat Asghar; Jamie Joseph; Michael B Wheeler; Nada A Abumrad; Derek LeRoith
Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice.
Endocrinology 2004;145(10):4667-76.
2004: Raewyn M Seaberg; Simon R Smukler; Timothy J Kieffer; Grigori Enikolopov; Zeenat Asghar; Michael B Wheeler; Gregory S Korbutt; Derek van der Kooy
Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages.
Nature biotechnology 2004;22(9):1115-24.
2004: Patrick E MacDonald; Jamie W Joseph; Daphne Yau; Jingyu Diao; Zeenat Asghar; F Dai; Gavin Y Oudit; Mikin M Patel; Peter H Backx; Michael B Wheeler
Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase.
Endocrinology 2004;145(9):4078-83.
2004: Fuzhen Xia; Xiaodong Gao; Edwin P Kwan; Patrick P L Lam; Lillian Chan; Keiyan Sy; Laura Sheu; Michael B Wheeler; Herbert Y Gaisano; Robert G Tsushima
Disruption of pancreatic beta-cell lipid rafts modifies Kv2.1 channel gating and insulin exocytosis.
The Journal of biological chemistry 2004;279(23):24685-91.
2004: Catherine B Chan; Monique C Saleh; Vasilij Koshkin; Michael B Wheeler
Uncoupling protein 2 and islet function.
Diabetes 2004;53 Suppl 1():S136-42.
2004: Xiaolin Wang; Hui Li; Domenica De Leo; Wanbei Guo; Vasilij Koshkin; I George Fantus; Adria Giacca; Catherine B Chan; Sandy D Der; Michael B Wheeler
Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6.
Diabetes 2004;53(1):129-40.
2003: Patrick E MacDonald; Xiaolin Wang; Fuzhen Xia; Wasim El-Kholy; Elisha D Targonsky; Robert G Tsushima; Michael B Wheeler
Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.
The Journal of biological chemistry 2003;278(52):52446-53.
2003: Patrick E MacDonald; Michael B Wheeler
Voltage-dependent K(+) channels in pancreatic beta cells: role, regulation and potential as therapeutic targets.
Diabetologia 2003;46(8):1046-62.
2003: Hyunsook Kim; Martin Haluzik; Zeenat Asghar; Daphne Yau; Jamie W Joseph; Ana M Fernandez; Marc L Reitman; Shoshana Yakar; Bethel Stannard; Lisa Heron-Milhavet; Michael B Wheeler; Derek LeRoith
Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis.
Diabetes 2003;52(7):1770-8.
2003: Vasilij Koshkin; Xiaolin Wang; Philipp E Scherer; Catherine B Chan; Michael B Wheeler
Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids.
The Journal of biological chemistry 2003;278(22):19709-15.
2003: Wasim El-Kholy; Patrick E MacDonald; Jia-Hui Lin; Jing Wang; Jocelyn Manning Fox; Peter E Light; Qinghua Wang; Robert G Tsushima; Michael B Wheeler
The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(6):720-2.
2003: Patrick E MacDonald; Anne Marie F Salapatek; Michael B Wheeler
Temperature and redox state dependence of native Kv2.1 currents in rat pancreatic beta-cells.
The Journal of physiology 2003;546(Pt 3):647-53.
2002: Patrick E MacDonald; Anne Marie F Salapatek; Michael B Wheeler
Glucagon-like peptide-1 receptor activation antagonizes voltage-dependent repolarizing K(+) currents in beta-cells: a possible glucose-dependent insulinotropic mechanism.
Diabetes 2002;51 Suppl 3():S443-7.
2002: Patrick E MacDonald; Wasim El-Kholy; Michael J Riedel; Anne Marie F Salapatek; Peter E Light; Michael B Wheeler
The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion.
Diabetes 2002;51 Suppl 3():S434-42.
2002: Simon R Smukler; Lan Tang; Michael B Wheeler; Anne Marie F Salapatek
Exogenous nitric oxide and endogenous glucose-stimulated beta-cell nitric oxide augment insulin release.
Diabetes 2002;51(12):3450-60.
2002: Patrick E MacDonald; Sabine Sewing; Jianli Wang; Jamie W Joseph; Simon R Smukler; George Sakellaropoulos; Jing Wang; Monique C Saleh; Catherine B Chan; Robert G Tsushima; Anne Marie F Salapatek; Michael B Wheeler
Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.
The Journal of biological chemistry 2002;277(47):44938-45.
2002: Patrick E MacDonald; Guotang Wang; Sharon Tsuk; Chikvashvili Dodo; Youhou Kang; Lan Tang; Michael B Wheeler; Mark S Cattral; Jonathan R T Lakey; Anne Marie F Salapatek; Ilana Lotan; Herbert Y Gaisano
Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus.
Molecular endocrinology (Baltimore, Md.) 2002;16(11):2452-61.
2002: Jamie W Joseph; Vasilij Koshkin; Chen-Yu zhang; Jing Wang; Bradford B Lowell; Catherine B Chan; Michael B Wheeler
Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet.
Diabetes 2002;51(11):3211-9.
2002: Herbert Y Gaisano; Claes-Göran Ostenson; Laura Sheu; Michael B Wheeler; Suad Efendic
Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment.
Endocrinology 2002;143(11):4218-26.
2002: Peter E Light; Jocelyn E Manning Fox; Michael J Riedel; Michael B Wheeler
Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism.
Molecular endocrinology (Baltimore, Md.) 2002;16(9):2135-44.
2002: Youhou Kang; Xiaohang Huang; Ewa A Pasyk; Junzhi Ji; G G Holz; Michael B Wheeler; Robert G Tsushima; Herbert Y Gaisano
Syntaxin-3 and syntaxin-1A inhibit L-type calcium channel activity, insulin biosynthesis and exocytosis in beta-cell lines.
Diabetologia 2002;45(2):231-41.
2002: Monique C Saleh; Michael B Wheeler; Catherine B Chan
Uncoupling protein-2: evidence for its function as a metabolic regulator.
Diabetologia 2002;45(2):174-87.
2001: Xiaohang Huang; Y H Kang; Ewa A Pasyk; Laura Sheu; Michael B Wheeler; William S Trimble; Anne Marie F Salapatek; Herbert Y Gaisano
Ca(2+) influx and cAMP elevation overcame botulinum toxin A but not tetanus toxin inhibition of insulin exocytosis.
American journal of physiology. Cell physiology 2001;281(3):C740-50.
2001: Patrick E MacDonald; X F Ha; Jing Wang; Simon R Smukler; AM Sun; Herbert Y Gaisano; Anne Marie F Salapatek; Peter H Backx; Michael B Wheeler
Members of the Kv1 and Kv2 voltage-dependent K(+) channel families regulate insulin secretion.
Molecular endocrinology (Baltimore, Md.) 2001;15(8):1423-35.
2001: Catherine B Chan; D De Leo; Jamie W Joseph; Tim McQuaid; X F Ha; F Xu; Robert G Tsushima; Peter Pennefather; Anne Marie F Salapatek; Michael B Wheeler
Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action.
Diabetes 2001;50(6):1302-10.
2001: K S Go; Rania Lingas; Michael B Wheeler; David M Irwin; Stephen G Matthews
Decreased CRH mRNA expression in the fetal guinea pig hypothalamus following maternal nutrient restriction.
Brain research 2001;896(1-2):179-82.
2001: Q Xiao; J Giguere; M Parisien; Winnie Jeng; S A St-Pierre; Patricia L Brubaker; Michael B Wheeler
Biological activities of glucagon-like peptide-1 analogues in vitro and in vivo.
Biochemistry 2001;40(9):2860-9.
2001: Prashanth Sivarajah; Michael B Wheeler; David M Irwin
Evolution of receptors for proglucagon-derived peptides: isolation of frog glucagon receptors.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2001;128(3):517-27.
2000: Q Xiao; Winnie Jeng; Michael B Wheeler
Characterization of glucagon-like peptide-1 receptor-binding determinants.
Journal of molecular endocrinology 2000;25(3):321-35.
1999: Michael B Wheeler; Rick Gelling; Simon Hinke; B Tu; Raymond A Pederson; Francis C Lynn; Jan A Ehses; Christopher H S McIntosh
Characterization of the carboxyl-terminal domain of the rat glucose-dependent insulinotropic polypeptide (GIP) receptor. A role for serines 426 and 427 in regulating the rate of internalization.
The Journal of biological chemistry 1999;274(35):24593-601.
1999: Anne Marie F Salapatek; Patrick E MacDonald; Herbert Y Gaisano; Michael B Wheeler
Mutations to the third cytoplasmic domain of the glucagon-like peptide 1 (GLP-1) receptor can functionally uncouple GLP-1-stimulated insulin secretion in HIT-T15 cells.
Molecular endocrinology (Baltimore, Md.) 1999;13(8):1305-17.
1999: Catherine B Chan; Patrick E MacDonald; Monique C Saleh; D C Johns; E Marbàn; Michael B Wheeler
Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.
Diabetes 1999;48(7):1482-6.
1999: Harmanjit Sandhu; Stephanie R Wiesenthal; Patrick E MacDonald; RH McCall; Vaja Tchipashvili; S Rashid; Malathy Satkunarajah; David M Irwin; ZQ Shi; Patricia L Brubaker; Michael B Wheeler; Mladen Vranic; Suad Efendic; Adria Giacca
Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs.
Diabetes 1999;48(5):1045-53.
1999: Catherine B Chan; RM MacPhail; L Sheu; Michael B Wheeler; Herbert Y Gaisano
Beta-cell hypertrophy in fa/fa rats is associated with basal glucose hypersensitivity and reduced SNARE protein expression.
Diabetes 1999;48(5):997-1005.
1998: E Kintsurashvili; D Zhou; Michael B Wheeler; I Vacek; AM Sun
Genetic engineering of glucose-stimulated insulin secretion in Chinese hamster ovary cells.
Artificial cells, blood substitutes, and immobilization biotechnology 1998;26(4):329-40.
1998: Xiaohang Huang; Michael B Wheeler; Y H Kang; Laura Sheu; Gergely L Lukacs; William S Trimble; Herbert Y Gaisano
Truncated SNAP-25 (1-197), like botulinum neurotoxin A, can inhibit insulin secretion from HIT-T15 insulinoma cells.
Molecular endocrinology (Baltimore, Md.) 1998;12(7):1060-70.
1998: Raymond A Pederson; Malathy Satkunarajah; Christopher H S McIntosh; LA Scrocchi; Daisy Flamez; Frans Schuit; Daniel J Drucker; Michael B Wheeler
Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice.
Diabetes 1998;47(7):1046-52.
1998: D Zhou; AM Sun; X Li; SN Mamujee; I Vacek; John Georgiou; Michael B Wheeler
In vitro and in vivo evaluation of insulin-producing beta TC6-F7 cells in microcapsules.
The American journal of physiology 1998;274(5 Pt 1):C1356-62.
1997: David M Irwin; Malathy Satkunarajah; Y Wen; Patricia L Brubaker; Raymond A Pederson; Michael B Wheeler
The Xenopus proglucagon gene encodes novel GLP-1-like peptides with insulinotropic properties.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):7915-20.
1997: Rick Gelling; Michael B Wheeler; J Xue; S Gyomorey; Cuilan Nian; Raymond A Pederson; Christopher H S McIntosh
Localization of the domains involved in ligand binding and activation of the glucose-dependent insulinotropic polypeptide receptor.
Endocrinology 1997;138(6):2640-3.
1997: Rick Gelling; D H Coy; Raymond A Pederson; Michael B Wheeler; Simon Hinke; T Kwan; Christopher H S McIntosh
GIP(6-30amide) contains the high affinity binding region of GIP and is a potent inhibitor of GIP1-42 action in vitro.
Regulatory peptides 1997;69(3):151-4.
1997: S K Mathi; Y Chan; X Li; Michael B Wheeler
Scanning of the glucagon-like peptide-1 receptor localizes G protein-activating determinants primarily to the N terminus of the third intracellular loop.
Molecular endocrinology (Baltimore, Md.) 1997;11(4):424-32.
1997: SN Mamujee; D Zhou; Michael B Wheeler; I Vacek; AM Sun
Evaluation of immunoisolated insulin-secreting beta TC6-F7 cells as a bioartificial pancreas.
Annals of transplantation : quarterly of the Polish Transplantation Society 1997;2(3):27-32.
1996: Christopher H S McIntosh; Michael B Wheeler; Rick Gelling; J C Brown; Raymond A Pederson
GIP receptors and signal-transduction mechanisms.
Acta physiologica Scandinavica 1996;157(3):361-5.
1996: S Takhar; S Gyomorey; Ruey-Chyi Su; S K Mathi; X Li; Michael B Wheeler
The third cytoplasmic domain of the GLP-1[7-36 amide] receptor is required for coupling to the adenylyl cyclase system.
Endocrinology 1996;137(5):2175-8.
1996: Michael B Wheeler; Laura Sheu; M Ghai; A Bouquillon; Gilles Grondin; U Weller; A R Beaudoin; MK Bennett; William S Trimble; Herbert Y Gaisano
Characterization of SNARE protein expression in beta cell lines and pancreatic islets.
Endocrinology 1996;137(4):1340-8.
1995: Michael B Wheeler; Rick Gelling; Christopher H S McIntosh; John Georgiou; J C Brown; Raymond A Pederson
Functional expression of the rat pancreatic islet glucose-dependent insulinotropic polypeptide receptor: ligand binding and intracellular signaling properties.
Endocrinology 1995;136(10):4629-39.
1989: Raymond A Pederson; R V Campos; Catherine B Chan; Alison M J Buchan; Michael B Wheeler; J C Brown
Gastrin release in obese Zucker rats.
Regulatory peptides 1989;24(2):131-42.
1987: R V Campos; Michael B Wheeler; Raymond A Pederson; Alison M J Buchan; J C Brown
The effect of total parenteral nutrition (TPN) on gastrin release in the rat.
Regulatory peptides 1987;19(5-6):281-9.