FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Thomas Braulke

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Disorders

Mucolipidoses

Physiology

Concepts & Ideas

Molecular Sequence Data

Co-author Network

Publications

TOP 3
Mine Franke; Thomas Braulke; Stephan Storch
Transport of the GlcNAc-1-phosphotransferase α/β-subunit precursor protein to the Golgi apparatus requires a combinatorial sorting motif.
K Kollmann; Torben Lübke; S Markmann; J-C Michalski; W Morelle; Sandra Pohl; A K Röchert; Michaela Schweizer; Steven U Walkley; M Damme; I Hermans-Borgmeyer; Reijo Kakela; Thomas Braulke
Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice.
Melanie Thelen; Michaela Schweizer; Thomas Braulke; Susanne Fehr; Giovanna Galliciotti
High expression of disease-related Cln6 in the cerebral cortex, purkinje cells, dentate gyrus, and hippocampal ca1 neurons.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Thomas Braulke (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Mine Franke; Thomas Braulke; Stephan Storch
Transport of the GlcNAc-1-phosphotransferase α/β-subunit precursor protein to the Golgi apparatus requires a combinatorial sorting motif.
The Journal of biological chemistry 2013;288(2):1238-49.
2012: K Kollmann; Torben Lübke; S Markmann; J-C Michalski; W Morelle; Sandra Pohl; A K Röchert; Michaela Schweizer; Steven U Walkley; M Damme; I Hermans-Borgmeyer; Reijo Kakela; Thomas Braulke
Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice.
Brain : a journal of neurology 2012;135(Pt 9):2661-75.
2012: Melanie Thelen; Michaela Schweizer; Thomas Braulke; Susanne Fehr; Giovanna Galliciotti
High expression of disease-related Cln6 in the cerebral cortex, purkinje cells, dentate gyrus, and hippocampal ca1 neurons.
Journal of neuroscience research 2012;90(3):568-74.
2012: Melanie Thelen; Andrew M S Wong; Markus Damme; Christian Hagel; Michaela Schweizer; Thomas Braulke; Jonathan D Cooper; Markus Daμμe; Giovanna Galliciotti
Disruption of the autophagy-lysosome pathway is involved in neuropathology of the nclf mouse model of neuronal ceroid lipofuscinosis.
PloS one 2012;7(4):e35493.
2011: Katrin Marschner; Thomas Braulke; Katrin Kollmann; Michaela Schweizer; Sandra Pohl
A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism.
Science (New York, N.Y.) 2011;333(6038):87-90.
2011: Nicole Muschol; Sandra Pohl; Kurt Ullrich; Andreas Gal; Ann Meyer; Thomas Braulke
Residual activity and proteasomal degradation of p.Ser298Pro sulfamidase identified in patients with a mild clinical phenotype of Sanfilippo A syndrome.
American journal of medical genetics. Part A 2011;155A(7):1634-9.
2011: Jessica Lamp; Britta Keyser; David M Koeller; Kurt Ullrich; Thomas Braulke; Chris Mühlhausen
Glutaric aciduria type 1 metabolites impair the succinate transport from astrocytic to neuronal cells.
The Journal of biological chemistry 2011;286(20):17777-84.
2011: Berta Puig; Dana Thurm; Hermann C Altmeppen; Thomas Braulke; Catharina Conrad; Markus Geissen; Markus Glatzel
N-glycans and glycosylphosphatidylinositol-anchor act on polarized sorting of mouse PrP(C) in Madin-Darby canine kidney cells.
PloS one 2011;6(9):e24624.
2011: Anne-Hélène Lebrun; Georgia Makrypidi; Sara E Mole; Parisa Moll-Khosrawi; Benjamin Otto; Sandra Pohl; Thomas Braulke; Susan Cotman; Dirk Kilian; Alfried Kohlschuetter; Stephan Storch; Thomas Streichert; Kurt Ullrich; Angela Schulz
Analysis of potential biomarkers and modifier genes affecting the clinical course of CLN3 disease.
Molecular medicine (Cambridge, Mass.) 2011;17(11-12):1253-61.
2010: Sandra Pohl; Stephan Tiede; Katrin Marschner; Marisa Encarnação; Monica Castrichini; Katrin Kollmann; Nicole Muschol; Kurt Ullrich; Sven Müller-Loennies; Thomas Braulke
Proteolytic processing of the gamma-subunit is associated with the failure to form GlcNAc-1-phosphotransferase complexes and mannose 6-phosphate residues on lysosomal enzymes in human macrophages.
The Journal of biological chemistry 2010;285(31):23936-44.
2010: Sven Müller-Loennies; Giovanna Galliciotti; Katrin Kollmann; Markus Glatzel; Thomas Braulke
A novel single-chain antibody fragment for detection of mannose 6-phosphate-containing proteins: application in mucolipidosis type II patients and mice.
The American journal of pathology 2010;177(1):240-7.
2010: Pieter Steenhuis; Stephanie Herder; Suyin Gelis; Thomas Braulke; Stephan Storch
Lysosomal targeting of the CLN7 membrane glycoprotein and transport via the plasma membrane require a dileucine motif.
Traffic (Copenhagen, Denmark) 2010;11(7):987-1000.
2010: Anna-Katherina Kurze; Giovanna Galliciotti; Claudia Heine; Sara E Mole; Arne Quitsch; Thomas Braulke
Pathogenic mutations cause rapid degradation of lysosomal storage disease-related membrane protein CLN6.
Human mutation 2010;31(2):E1163-74.
2010: Stephan Schröder; Frank Matthes; Pia Hyden; Claes Andersson; Jens Fogh; Sven Müller-Loennies; Thomas Braulke; Volkmar Gieselmann; Ulrich Matzner
Site-specific analysis of N-linked oligosaccharides of recombinant lysosomal arylsulfatase A produced in different cell lines.
Glycobiology 2010;20(2):248-59.
2010: Joachim Thiem; Thomas Braulke
Glycostructures in biological systems - synthesis and function.
European journal of cell biology 2010;89(1):1.
2010: Sandra Pohl; Marisa Encarnacão; Monica Castrichini; Sven Müller-Loennies; Nicole Muschol; Thomas Braulke
Loss of N-acetylglucosamine-1-phosphotransferase gamma subunit due to intronic mutation in GNPTG causes mucolipidosis type III gamma: Implications for molecular and cellular diagnostics.
American journal of medical genetics. Part A 2010;152A(1):124-32.
2010: Katrin Kollmann; Sandra Pohl; Katrin Marschner; Marisa Encarnação; Imme Sakwa; Stephan Tiede; Ben J Poorthuis; Torben Lübke; Sven Müller-Loennies; Stephan Storch; Thomas Braulke
Mannose phosphorylation in health and disease.
European journal of cell biology 2010;89(1):117-23.
2009: Sandra Pohl; Katrin Marschner; Stephan Storch; Thomas Braulke
Glycosylation- and phosphorylation-dependent intracellular transport of lysosomal hydrolases.
Biological chemistry 2009;390(7):521-7.
2009: Anne-Hélène Lebrun; Stephan Storch; Franz Rüschendorf; Mia-Lisa Schmiedt; Aija Kyttälä; Sara E Mole; Claudia Kitzmüller; Kathrin Saar; Leena D Mewasingh; Volker Boda; Alfried Kohlschuetter; Kurt Ullrich; Thomas Braulke; Angela Schulz
Retention of lysosomal protein CLN5 in the endoplasmic reticulum causes neuronal ceroid lipofuscinosis in Asian sibship.
Human mutation 2009;30(5):E651-61.
2009: Volkmar Gieselmann; Thomas Braulke
Lysosomes.
Biochimica et biophysica acta 2009;1793(4):603-4.
2009: Anu Jalanko; Thomas Braulke
Neuronal ceroid lipofuscinoses.
Biochimica et biophysica acta 2009;1793(4):697-709.
2009: Thomas Braulke; Juan Bonifacino
Sorting of lysosomal proteins.
Biochimica et biophysica acta 2009;1793(4):605-14.
2009: Sandra Pohl; Stephan Tiede; Monica Castrichini; Michael Cantz; Volkmar Gieselmann; Thomas Braulke
Compensatory expression of human N-acetylglucosaminyl-1-phosphotransferase subunits in mucolipidosis type III gamma.
Biochimica et biophysica acta 2009;1792(3):221-5.
2009: Diana Klein; Afshin Yaghootfam; Ulrich Matzner; Bettina Koch; Thomas Braulke; Volkmar Gieselmann
Mannose 6-phosphate receptor-dependent endocytosis of lysosomal enzymes is increased in sulfatide-storing kidney cells.
Biological chemistry 2009;390(1):41-8.
2008: Britta Keyser; Chris Mühlhausen; Achim Dickmanns; Ernst Christensen; Nicole Muschol; Kurt Ullrich; Thomas Braulke
Disease-causing missense mutations affect enzymatic activity, stability and oligomerization of glutaryl-CoA dehydrogenase (GCDH).
Human molecular genetics 2008;17(24):3854-63.
2008: L Shalamanova; Bernd Kübler; Stephan Storch; Jens-Gerd Scharf; Thomas Braulke
Multiple post-translational modifications of mouse insulin-like growth factor binding protein-6 expressed in epithelial Madin-Darby canine kidney cells.
Molecular and cellular endocrinology 2008;295(1-2):18-23.
2008: Yohannes Hagos; Wolfgang Krick; Thomas Braulke; Chris Mühlhausen; Gerhard Burckhardt; Birgitta C Burckhardt
Organic anion transporters OAT1 and OAT4 mediate the high affinity transport of glutarate derivatives accumulating in patients with glutaric acidurias.
Pflügers Archiv : European journal of physiology 2008;457(1):223-31.
2008: Sabrina Jabs; Arne Quitsch; Reijo Kakela; Bettina Koch; Jaana Tyynelä; Helmut Brade; Markus Glatzel; Steven U Walkley; Paul Saftig; marie T vanier; Thomas Braulke
Accumulation of bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosis.
Journal of neurochemistry 2008;106(3):1415-25.
2008: Britta Keyser; Markus Glatzel; Franziska Stellmer; Bastian Kortmann; Zoltan Lukacs; Stefan Kölker; Sven W Sauer; Nicole Muschol; Wilhelm Herdering; Joachim Thiem; Stephen I Goodman; David M Koeller; Kurt Ullrich; Thomas Braulke; Chris Mühlhausen
Transport and distribution of 3-hydroxyglutaric acid before and during induced encephalopathic crises in a mouse model of glutaric aciduria type 1.
Biochimica et biophysica acta 2008;1782(6):385-90.
2008: Ann Meyer; Kai Kossow; Andreas Gal; Cordula Steglich; Chris Mühlhausen; Kurt Ullrich; Thomas Braulke; Nicole Muschol
The mutation p.Ser298Pro in the sulphamidase gene (SGSH) is associated with a slowly progressive clinical phenotype in mucopolysaccharidosis type IIIA (Sanfilippo A syndrome).
Human mutation 2008;29(5):770.
2008: Thomas Braulke; Sandra Pohl; Stephan Storch
Molecular analysis of the GlcNac-1-phosphotransferase.
Journal of inherited metabolic disease 2008;31(2):253-7.
2008: Chris Mühlhausen; Kurt Ullrich; Birgitta C Burckhardt; Gerhard Burckhardt; Yohannes Hagos; B Keyser; Zoltan Lukacs; Thomas Braulke
Membrane translocation of glutaric acid and its derivatives.
Journal of inherited metabolic disease 2008;31(2):188-93.
2008: Sara S Cathey; Mariko Kudo; Stephan Tiede; Annick Raas-Rothschild; Thomas Braulke; Michael Beck; Harold A Taylor; William M Canfield; Jules G Leroy; Elizabeth F Neufeld; Victor A McKusick
Molecular order in mucolipidosis II and III nomenclature.
American journal of medical genetics. Part A 2008;146A(4):512-3.
2007: Sandra Pohl; Hannah M Mitchison; Alfried Kohlschuetter; Otto van Diggelen; Thomas Braulke; Stephan Storch
Increased expression of lysosomal acid phosphatase in CLN3-defective cells and mouse brain tissue.
Journal of neurochemistry 2007;103(6):2177-88.
2007: Ann Meyer; Kai Kossow; Andreas Gal; Chris Mühlhausen; Kurt Ullrich; Thomas Braulke; Nicole Muschol
Scoring evaluation of the natural course of mucopolysaccharidosis type IIIA (Sanfilippo syndrome type A).
Pediatrics 2007;120(5):e1255-61.
2007: Volker Viereck; Heide Siggelkow; Rajeswararao Pannem; Thomas Braulke; Jens-Gerd Scharf; Bernd Kübler
Alteration of the insulin-like growth factor axis during in vitro differentiation of the human osteosarcoma cell line HOS 58.
Journal of cellular biochemistry 2007;102(1):28-40.
2007: Franziska Stellmer; Britta Keyser; Birgitta C Burckhardt; Hermann Koepsell; Thomas Streichert; Markus Glatzel; Sabrina Jabs; Joachim Thiem; Wilhelm Herdering; David M Koeller; Stephen I Goodman; Zoltan Lukacs; Kurt Ullrich; Gerhard Burckhardt; Thomas Braulke; Chris Mühlhausen
3-Hydroxyglutaric acid is transported via the sodium-dependent dicarboxylate transporter NaDC3.
Journal of molecular medicine (Berlin, Germany) 2007;85(7):763-70.
2007: Stephan Storch; Sandra Pohl; Arne Quitsch; Katrin Falley; Thomas Braulke
C-terminal prenylation of the CLN3 membrane glycoprotein is required for efficient endosomal sorting to lysosomes.
Traffic (Copenhagen, Denmark) 2007;8(4):431-44.
2007: Claudia Heine; Arne Quitsch; Stephan Storch; Yella Martin; Liina Lonka; Anna-Elina Lehesjoki; Sara E Mole; Thomas Braulke
Topology and endoplasmic reticulum retention signals of the lysosomal storage disease-related membrane protein CLN6.
Molecular membrane biology 2007;24(1):74-87.
2006: Aija Kyttälä; Ulla Lahtinen; Thomas Braulke; Hofmann Sandra
Functional biology of the neuronal ceroid lipofuscinoses (NCL) proteins.
Biochimica et biophysica acta 2006;1762(10):920-33.
2006: Stephan Tiede; Michael Cantz; Jürgen Spranger; Thomas Braulke
Missense mutation in the N-acetylglucosamine-1-phosphotransferase gene (GNPTA) in a patient with mucolipidosis II induces changes in the size and cellular distribution of GNPTG.
Human mutation 2006;27(8):830-1.
2006: P Greimel; Sabrina Jabs; Stephan Storch; Slim Cherif; Koichi Honke; Thomas Braulke; Joachim Thiem
In vitro sulfation of N-acetyllactosaminide by soluble recombinant human beta-Gal-3'-sulfotransferase.
Carbohydrate research 2006;341(7):918-24.
2006: Chris Mühlhausen; Nicola Ott; Fariba Chalajour; Derya Tilki; Folke Freudenberg; Mona Shahhossini; Joachim Thiem; Kurt Ullrich; Thomas Braulke; Süleyman Ergün
Endothelial effects of 3-hydroxyglutaric acid: implications for glutaric aciduria type I.
Pediatric research 2006;59(2):196-202.
2005: Stephan Tiede; Stephan Storch; Torben Lübke; Bernard Henrissat; Ruth Bargal; Annick Raas-Rothschild; Thomas Braulke
Mucolipidosis II is caused by mutations in GNPTA encoding the alpha/beta GlcNAc-1-phosphotransferase.
Nature medicine 2005;11(10):1109-12.
2005: Stephan Tiede; Nicole Muschol; Gert Reutter; Michael Cantz; Kurt Ullrich; Thomas Braulke
Missense mutations in N-acetylglucosamine-1-phosphotransferase alpha/beta subunit gene in a patient with mucolipidosis III and a mild clinical phenotype.
American journal of medical genetics. Part A 2005;137A(3):235-40.
2005: Sandra Oesterreicher; Werner Blum; Bernhard Schmidt; Thomas Braulke; Bernd Kübler
Interaction of insulin-like growth factor II (IGF-II) with multiple plasma proteins: high affinity binding of plasminogen to IGF-II and IGF-binding protein-3.
The Journal of biological chemistry 2005;280(11):9994-10000.
2005: Silke Mark; Bernd Kübler; Stefan Höning; Sandra Oesterreicher; Harald John; Thomas Braulke; Wolf-Georg Forssmann; Ludger Ständker
Diversity of human insulin-like growth factor (IGF) binding protein-2 fragments in plasma: primary structure, IGF-binding properties, and disulfide bonding pattern.
Biochemistry 2005;44(9):3644-52.
2004: Stephan Storch; Sandra Pohl; Thomas Braulke
A dileucine motif and a cluster of acidic amino acids in the second cytoplasmic domain of the batten disease-related CLN3 protein are required for efficient lysosomal targeting.
The Journal of biological chemistry 2004;279(51):53625-34.
2004: Stephan Tiede; Michael Cantz; Annick Raas-Rothschild; Nicole Muschol; Friederike Bürger; Kurt Ullrich; Thomas Braulke
A novel mutation in UDP-N-acetylglucosamine-1-phosphotransferase gamma subunit (GNPTAG) in two siblings with mucolipidosis type III alters a used glycosylation site.
Human mutation 2004;24(6):535.
2004: Victoria Schebek-Fürstenberg; Ludger Ständker; Martin Oppermann; Dirk E Müller-Wiefel; Wilfried Hahn; Werner Blum; Thomas Braulke; Bernd Kübler
IGF-binding protein-3 fragments in plasma of a child with acute renal failure.
Pediatric nephrology (Berlin, Germany) 2004;19(12):1418-25.
2004: Elke Hammer; Kerstin Kutsche; Friedrich Haag; Kurt Ullrich; Ralf Sudbrak; Rolf Peter Willig; Thomas Braulke; Bernd Kubler
Mono-allelic expression of the IGF-I receptor does not affect IGF responses in human fibroblasts.
European journal of endocrinology / European Federation of Endocrine Societies 2004;151(4):521-9.
2004: Jens-Gerd Scharf; Frank Dombrowski; Ruslan Novosyadlyy; Christoph Eisenbach; Ilaria Demori; Bernd Kübler; Thomas Braulke
Insulin-like growth factor (IGF)-binding protein-1 is highly induced during acute carbon tetrachloride liver injury and potentiates the IGF-I-stimulated activation of rat hepatic stellate cells.
Endocrinology 2004;145(7):3463-72.
2004: Nicole Muschol; Stephan Storch; Diana Ballhausen; Clare E Beesley; Jan-Christoph Westermann; Andreas Gal; Kurt Ullrich; John J Hopwood; Bryan Winchester; Thomas Braulke
Transport, enzymatic activity, and stability of mutant sulfamidase (SGSH) identified in patients with mucopolysaccharidosis type III A.
Human mutation 2004;23(6):559-66.
2004: Claudia Heine; Bettina Koch; Stephan Storch; Alfried Kohlschuetter; David N Palmer; Thomas Braulke
Defective endoplasmic reticulum-resident membrane protein CLN6 affects lysosomal degradation of endocytosed arylsulfatase A.
The Journal of biological chemistry 2004;279(21):22347-52.
2004: Kostas Tsiakas; Robert Steinfeld; Stephan Storch; Junji Ezaki; Zoltan Lukacs; Eiki Kominami; Alfried Kohlschuetter; Kurt Ullrich; Thomas Braulke
Mutation of the glycosylated asparagine residue 286 in human CLN2 protein results in loss of enzymatic activity.
Glycobiology 2004;14(4):1C-5C.
2004: Chris Mühlhausen; Süleyman Ergün; KA Strauss; David M Koeller; Linda S Crnic; Michael Woontner; Stephen I Goodman; Kurt Ullrich; Thomas Braulke
Vascular dysfunction as an additional pathomechanism in glutaric aciduria type I.
Journal of inherited metabolic disease 2004;27(6):829-34.
2003: Claudia Heine; Jaana Tyynelä; Jonathan D Cooper; David N Palmer; Milan Elleder; Alfried Kohlschuetter; Thomas Braulke
Enhanced expression of manganese-dependent superoxide dismutase in human and sheep CLN6 tissues.
The Biochemical journal 2003;376(Pt 2):369-76.
2003: Jens-Gerd Scharf; Thomas Braulke
The role of the IGF axis in hepatocarcinogenesis.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(11-12):685-93.
2003: Christian Thiel; Markus Schwarz; Jianhe Peng; Michal Grzmil; Martin Hasilik; Thomas Braulke; Alfried Kohlschuetter; Kurt von Figura; Ludwig Lehle; Christian Körner
A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis.
The Journal of biological chemistry 2003;278(25):22498-505.
2003: Ludger Ständker; Bernd Kübler; Maik Obendorf; Thomas Braulke; Wolf-Georg Forssmann; Silke Mark
In vivo processed fragments of IGF binding protein-2 copurified with bioactive IGF-II.
Biochemical and biophysical research communications 2003;304(4):708-13.
2003: Stephan Storch; Birgit Wittenstein; Rafiqul Islam; Kurt Ullrich; William S Sly; Thomas Braulke
Mutational analysis in longest known survivor of mucopolysaccharidosis type VII.
Human genetics 2003;112(2):190-4.
2003: Sanna Partanen; Stephan Storch; Hans-Gerhard Löffler; Andrej Hasilik; Jaana Tyynelä; Thomas Braulke
A replacement of the active-site aspartic acid residue 293 in mouse cathepsin D affects its intracellular stability, processing and transport in HEK-293 cells.
The Biochemical journal 2003;369(Pt 1):55-62.
2002: Nicole Muschol; Ulrich Matzner; Stephan Tiede; Volkmar Gieselmann; Kurt Ullrich; Thomas Braulke
Secretion of phosphomannosyl-deficient arylsulphatase A and cathepsin D from isolated human macrophages.
The Biochemical journal 2002;368(Pt 3):845-53.
2002: Bernd Kübler; Claudia Draeger; Harald John; Uwe Andag; Jens-Gerd Scharf; Wolf-Georg Forssmann; Thomas Braulke; Ludger Ständker
Isolation and characterization of circulating fragments of the insulin-like growth factor binding protein-3.
FEBS letters 2002;518(1-3):124-8.
2002: Olaf Zwad; Bernd Kübler; Wera Roth; Jens-Gerd Scharf; Paul Saftig; Christof Peters; Thomas Braulke
Decreased intracellular degradation of insulin-like growth factor binding protein-3 in cathepsin L-deficient fibroblasts.
FEBS letters 2002;510(3):211-5.
2001: Stephan Storch; Bernd Kübler; Stefan Höning; M Ackmann; J Zapf; W Blum; Thomas Braulke
Transferrin binds insulin-like growth factors and affects binding properties of insulin-like growth factor binding protein-3.
FEBS letters 2001;509(3):395-8.
2001: L Shalamanova; Bernd Kübler; Jens-Gerd Scharf; Thomas Braulke
MDCK cells secrete neutral proteases cleaving insulin-like growth factor-binding protein-2 to -6.
American journal of physiology. Endocrinology and metabolism 2001;281(6):E1221-9.
2001: P Putzer; Werner Götz; Rupert Dempf; Thomas Braulke
[Immunohistochemical localization of insulin-like-growth-factor-binding protein 6 in the head area of the mouse].
Mund-, Kiefer- und Gesichtschirurgie : MKG 2001;5(4):251-7.
2001: Jens-Gerd Scharf; Thomas Braulke; H Hartmann; Giuliano Ramadori
Regulation of the components of the 150 kDa IGF binding protein complex in cocultures of rat hepatocytes and Kupffer cells by 3',5'-cyclic adenosine monophosphate.
Journal of cellular physiology 2001;186(3):425-36.
2001: Stephan Storch; Thomas Braulke
Multiple C-terminal motifs of the 46-kDa mannose 6-phosphate receptor tail contribute to efficient binding of medium chains of AP-2 and AP-3.
The Journal of biological chemistry 2001;276(6):4298-303.
2000: L Shalamanova; Bernd Kübler; Jens-Gerd Scharf; Thomas Braulke
Ligand blotting: iodinated vs biotinylated IGF.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2000;10(5):294.
2000: Ludger Ständker; Thomas Braulke; Silke Mark; H Mostafavi; M Meyer; Stefan Höning; Guillermo Giménez-Gallego; Wolf-Georg Forssmann
Partial IGF affinity of circulating N- and C-terminal fragments of human insulin-like growth factor binding protein-4 (IGFBP-4) and the disulfide bonding pattern of the C-terminal IGFBP-4 domain.
Biochemistry 2000;39(17):5082-8.
1999: Thomas Braulke
Type-2 IGF receptor: a multi-ligand binding protein.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1999;31(2-3):242-6.
1999: Thomas Braulke; F Dittmer; Werner Götz; Kurt von Figura
Alteration in pancreatic immunoreactivity of insulin-like growth factor (IGF)-binding protein (IGFBP)-6 and in intracellular degradation of IGFBP-3 in fibroblasts of IGF-II receptor/IGF-II-deficient mice.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1999;31(2-3):235-41.
1998: Peter Breuer; Thomas Braulke
Stabilization of mutant 46-kDa mannose 6-phosphate receptors by proteasomal inhibitor lactacystin.
The Journal of biological chemistry 1998;273(50):33254-8.
1998: J G Scharf; W Schmidt-Sandte; S A Pahernik; G Ramadori; Thomas Braulke; H Hartmann
Characterization of the insulin-like growth factor axis in a human hepatoma cell line (PLC).
Carcinogenesis 1998;19(12):2121-8.
1998: Jens-Gerd Scharf; Thomas Knittel; Frank Dombrowski; L Müller; Bernhard Saile; Thomas Braulke; H Hartmann; Giuliano Ramadori
Characterization of the IGF axis components in isolated rat hepatic stellate cells.
Hepatology (Baltimore, Md.) 1998;27(5):1275-84.
1998: Bernd Kübler; S Cowell; J Zapf; Thomas Braulke
Proteolysis of insulin-like growth factor binding proteins by a novel 50-kilodalton metalloproteinase in human pregnancy serum.
Endocrinology 1998;139(4):1556-63.
1998: P Putzer; Peter Breuer; Werner Götz; M Gross; Bernd Kübler; Jens-Gerd Scharf; A G Schuller; H Hartmann; Thomas Braulke
Mouse insulin-like growth factor binding protein-6: expression, purification, characterization and histochemical localization.
Molecular and cellular endocrinology 1998;137(1):69-78.
1997: Maike Claussen; Bernd Kübler; M Wendland; K Neifer; Bernhard Schmidt; J Zapf; Thomas Braulke
Proteolysis of insulin-like growth factors (IGF) and IGF binding proteins by cathepsin D.
Endocrinology 1997;138(9):3797-803.
1997: Peter Breuer; Christian Körner; C Böker; A Herzog; Regina Pohlmann; Thomas Braulke
Serine phosphorylation site of the 46-kDa mannose 6-phosphate receptor is required for transport to the plasma membrane in Madin-Darby canine kidney and mouse fibroblast cells.
Molecular biology of the cell 1997;8(4):567-76.
1996: Thomas Braulke; Werner Götz; Maike Claussen
Immunohistochemical localization of insulin-like growth factor binding protein-1, -3 and -4 in human fetal tissues and their analysis in media from fetal tissue explants.
Growth regulation 1996;6(2):55-65.
1996: O Rosorius; Olaf-Georg Issinger; Thomas Braulke
Brain-specific interaction of a 91-kDa membrane-bound protein with the cytoplasmic tail of the 300-kDa mannose 6-phosphate receptor.
Biochemical and biophysical research communications 1996;221(3):525-30.
1996: Christian Körner; Thomas Braulke
Inhibition of IGF II-induced redistribution of mannose 6-phosphate receptors by the phosphatidylinositol 3-kinase inhibitor, wortmannin.
Molecular and cellular endocrinology 1996;118(1-2):201-5.
1996: J Scharf; Giuliano Ramadori; Thomas Braulke; H Hartmann
Synthesis of insulinlike growth factor binding proteins and of the acid-labile subunit in primary cultures of rat hepatocytes, of Kupffer cells, and in cocultures: regulation by insulin, insulinlike growth factor, and growth hormone.
Hepatology (Baltimore, Md.) 1996;23(4):818-27.
1996: Thomas Braulke
Origin of lysosomal proteins.
Sub-cellular biochemistry 1996;27():15-49.
1995: Maike Claussen; D Buergisser; A G Schuller; U Matzner; Thomas Braulke
Regulation of insulin-like growth factor (IGF)-binding protein-6 and mannose 6-phosphate/IGF-II receptor expression in IGF-IL-overexpressing NIH 3T3 cells.
Molecular endocrinology (Baltimore, Md.) 1995;9(7):902-12.
1995: Bernhard Schmidt; C Kiecke-Siemsen; A Waheed; Thomas Braulke; Kurt von Figura
Localization of the insulin-like growth factor II binding site to amino acids 1508-1566 in repeat 11 of the mannose 6-phosphate/insulin-like growth factor II receptor.
The Journal of biological chemistry 1995;270(25):14975-82.
1995: F Schmitz; R Bresciani; H Hartmann; Thomas Braulke
Effect of insulin-like growth factor II on uptake of arylsulfatase A by cultured rat hepatocytes and Kupffer cells.
Journal of hepatology 1995;22(3):356-63.
1995: Christian Körner; B Nürnberg; M Uhde; Thomas Braulke
Mannose 6-phosphate/insulin-like growth factor II receptor fails to interact with G-proteins. Analysis of mutant cytoplasmic receptor domains.
The Journal of biological chemistry 1995;270(1):287-95.
1995: Thomas Braulke; Maike Claussen; Paul Saftig; M Wendland; K Neifer; Bernhard Schmidt; J Zapf; Kurt von Figura; Christoph Peters
Proteolysis of IGFBPs by cathepsin D in vitro and in cathepsin D-deficient mice.
Progress in growth factor research 1995;6(2-4):265-71.
1995: Jens-Gerd Scharf; Giuliano Ramadori; Thomas Braulke; H Hartmann
Cellular localization and hormonal regulation of biosynthesis of insulin-like growth factor binding proteins and of the acid-labile subunit within rat liver.
Progress in growth factor research 1995;6(2-4):175-80.
1994: Christian Körner; A Herzog; B Weber; O Rosorius; F Hemer; Bernhard Schmidt; Thomas Braulke
In vitro phosphorylation of the 46-kDa mannose 6-phosphate receptor by casein kinase II. Structural requirements for efficient phosphorylation.
The Journal of biological chemistry 1994;269(24):16529-32.
1994: Maike Claussen; J Zapf; Thomas Braulke
Proteolysis of insulin-like growth factor binding protein-5 by pregnancy serum and amniotic fluid.
Endocrinology 1994;134(4):1964-6.
1994: H Damke; H Bouterfa; Thomas Braulke
Effects of insulin-like growth factor II on the generation of inositol trisphosphate, diacylglycerol and cAMP in human fibroblasts.
Molecular and cellular endocrinology 1994;99(2):R25-9.
1993: F Diesner; H J Sommerlade; Thomas Braulke
Transport of newly synthesized arylsulfatase A to the lysosome via transferrin receptor-positive compartments.
Biochemical and biophysical research communications 1993;197(1):1-7.
1993: O Rosorius; Olaf-Georg Issinger; Thomas Braulke
Phosphorylation of the cytoplasmic tail of the 300-kDa mannose 6-phosphate receptor is required for the interaction with a cytosolic protein.
The Journal of biological chemistry 1993;268(29):21470-3.
1993: F Hemer; Christian Körner; Thomas Braulke
Phosphorylation of the human 46-kDa mannose 6-phosphate receptor in the cytoplasmic domain at serine 56.
The Journal of biological chemistry 1993;268(23):17108-13.
1993: O Rosorius; G Mieskes; Olaf-Georg Issinger; Christian Körner; Bernhard Schmidt; Kurt von Figura; Thomas Braulke
Characterization of phosphorylation sites in the cytoplasmic domain of the 300 kDa mannose-6-phosphate receptor.
The Biochemical journal 1993;292 ( Pt 3)():833-8.
1992: Thomas Braulke; G Mieskes
Role of protein phosphatases in insulin-like growth factor II (IGF II)-stimulated mannose 6-phosphate/IGF II receptor redistribution.
The Journal of biological chemistry 1992;267(24):17347-53.
1992: H Damke; J Klumperman; Kurt von Figura; Thomas Braulke
Brefeldin A affects the cellular distribution of endocytic receptors differentially.
Biochemical and biophysical research communications 1992;185(2):719-27.
1992: Thomas Braulke; S Tippmer; U Matzner; C Gartung; Kurt von Figura
Mannose 6-phosphate/insulin-like growth factor II receptor in I-cell disease fibroblasts: increased synthesis and defective regulation of cell surface expression.
Biochimica et biophysica acta 1992;1138(4):334-42.
1992: H Hartmann; A Meyer-Alber; Thomas Braulke
Metabolic actions of insulin-like growth factor II in cultured adult rat hepatocytes are not mediated through the insulin-like growth factor II receptor.
Diabetologia 1992;35(3):216-23.
1992: H Damke; Kurt von Figura; Thomas Braulke
Simultaneous redistribution of mannose 6-phosphate and transferrin receptors by insulin-like growth factors and phorbol ester.
The Biochemical journal 1992;281 ( Pt 1)():225-9.
1991: H Damke; J Klumperman; Kurt von Figura; Thomas Braulke
Effects of brefeldin A on the endocytic route. Redistribution of mannose 6-phosphate/insulin-like growth factor II receptors to the cell surface.
The Journal of biological chemistry 1991;266(36):24829-33.
1991: Thomas Braulke; R Bresciani; D M Buergisser; Kurt von Figura
Insulin-like growth factor II overexpression does not affect sorting of lysosomal enzymes in NIH-3T3 cells.
Biochemical and biophysical research communications 1991;179(1):108-15.
1990: Thomas Braulke; S Tippmer; H J Chao; Kurt von Figura
Regulation of mannose 6-phosphate/insulin-like growth factor II receptor distribution by activators and inhibitors of protein kinase C.
European journal of biochemistry / FEBS 1990;189(3):609-16.
1990: Thomas Braulke; S Tippmer; H J Chao; Kurt von Figura
Insulin-like growth factors I and II stimulate endocytosis but do not affect sorting of lysosomal enzymes in human fibroblasts.
The Journal of biological chemistry 1990;265(12):6650-5.
1990: A Hille; Thomas Braulke; Kurt von Figura; Wieland B Huttner
Occurrence of tyrosine sulfate in proteins--a balance sheet. 1. Secretory and lysosomal proteins.
European journal of biochemistry / FEBS 1990;188(3):577-86.
1989: Thomas Braulke; S Tippmer; Erwin Neher; Kurt von Figura
Regulation of the mannose 6-phosphate/IGF II receptor expression at the cell surface by mannose 6-phosphate, insulin like growth factors and epidermal growth factor.
The EMBO journal 1989;8(3):681-6.
1989: Regina Pohlmann; G Nagel; A Hille; M Wendland; A Waheed; Thomas Braulke; Kurt von Figura
Mannose 6-phosphate specific receptors: structure and function.
Biochemical Society transactions 1989;17(1):15-6.
1988: A Waheed; S Gottschalk; A Hille; C Krentler; Regina Pohlmann; Thomas Braulke; H Hauser; H Geuze; Kurt von Figura
Human lysosomal acid phosphatase is transported as a transmembrane protein to lysosomes in transfected baby hamster kidney cells.
The EMBO journal 1988;7(8):2351-8.
1988: C Causin; A Waheed; Thomas Braulke; U Junghans; P Maly; R E Humbel; Kurt von Figura
Mannose 6-phosphate/insulin-like growth factor II-binding proteins in human serum and urine. Their relation to the mannose 6-phosphate/insulin-like growth factor II receptor.
The Biochemical journal 1988;252(3):795-9.
1988: A Waheed; Thomas Braulke; U Junghans; Kurt von Figura
Mannose 6-phosphate/insulin like growth factor II receptor: the two types of ligands bind simultaneously to one receptor at different sites.
Biochemical and biophysical research communications 1988;152(3):1248-54.
1988: Thomas Braulke; C Causin; A Waheed; U Junghans; A Hasilik; P Maly; R E Humbel; Kurt von Figura
Mannose 6-phosphate/insulin-like growth factor II receptor: distinct binding sites for mannose 6-phosphate and insulin-like growth factor II.
Biochemical and biophysical research communications 1988;150(3):1287-93.
1988: Thomas Braulke; M Stein; Thorsten Marquardt; C Gartung; Andrej Hasilik; Kurt von Figura
Receptor-dependent transport of lysosomal enzymes.
Indian journal of biochemistry & biophysics 1988;25(1-2):95-101.
1987: Thorsten Marquardt; Thomas Braulke; Andrej Hasilik; Kurt von Figura
Association of the precursor of cathepsin D with coated membranes. Kinetics and carbohydrate processing.
European journal of biochemistry / FEBS 1987;168(1):37-42.
1987: M Stein; Thomas Braulke; C Krentler; Andrej Hasilik; Kurt von Figura
46-kDa mannose 6-phosphate-specific receptor: biosynthesis, processing, subcellular location and topology.
Biological chemistry Hoppe-Seyler 1987;368(8):937-47.
1987: Thomas Braulke; C Gartung; Andrej Hasilik; Kurt von Figura
Is movement of mannose 6-phosphate-specific receptor triggered by binding of lysosomal enzymes?
The Journal of cell biology 1987;104(6):1735-42.
1987: Thomas Braulke; A Hille; Wieland B Huttner; A Hasilik; Kurt von Figura
Sulfated oligosaccharides in human lysosomal enzymes.
Biochemical and biophysical research communications 1987;143(1):178-85.
1987: K von Figura; A Hasilik; Regina Pohlmann; Thomas Braulke; P Lemansky; M Stein
Mutations affecting transport and stability of lysosomal enzymes.
Enzyme 1987;38(1-4):144-53.
1985: C Gartung; Thomas Braulke; Andrej Hasilik; Kurt von Figura
Internalization of blocking antibodies against mannose-6-phosphate specific receptors.
The EMBO journal 1985;4(7):1725-30.