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Vanessa Wheeler

Research Profile

Disorders

Chemicals & Drugs

Living Beings

Anatomy

Procedures

Gene Knock In Techniques

Physiology

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Publications

TOP 3
Marina Kovalenko; Melanie H Kucherlapati; Raju Kucherlapati; Jong-Min Lee; Jaclyn New; Jason St Claire; Hualing Dong; Ella Dragileva; Michelle E Ehrlich; Tammy Gillis; Jolene R Guide; Vanessa C Wheeler
Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.
Elisa Fossale; James Gusella; Isaac S Kohane; Marcy E MacDonald; Ihn Sik Seong; Toshi Shioda; Vanessa C Wheeler; Kathryn R Coser; Jong-Min Lee
Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative.
Jong-Min Lee; Ricardo Mouro Pinto; Jason C St Claire; Tammy Gillis; Vanessa C Wheeler
Quantification of age-dependent somatic CAG repeat instability in Hdh CAG knock-in mice reveals different expansion dynamics in striatum and liver.

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All Publications

2012: Marina Kovalenko; Melanie H Kucherlapati; Raju Kucherlapati; Jong-Min Lee; Jaclyn New; Jason St Claire; Hualing Dong; Ella Dragileva; Michelle E Ehrlich; Tammy Gillis; Jolene R Guide; Vanessa C Wheeler
Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.
PloS one 2012;7(9):e44273.
2011: Elisa Fossale; James Gusella; Isaac S Kohane; Marcy E MacDonald; Ihn Sik Seong; Toshi Shioda; Vanessa C Wheeler; Kathryn R Coser; Jong-Min Lee
Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative.
Human molecular genetics 2011;20(21):4258-67.
2011: Jong-Min Lee; Ricardo Mouro Pinto; Jason C St Claire; Tammy Gillis; Vanessa C Wheeler
Quantification of age-dependent somatic CAG repeat instability in Hdh CAG knock-in mice reveals different expansion dynamics in striatum and liver.
PloS one 2011;6(8):e23647.
2010: Ihn Sik Seong; Juliana M Woda; Ji-Joon Song; Alejandro Lloret; Priyanka D Abeyrathne; Caroline J Woo; Gillian Gregory; Jong-Min Lee; Vanessa C Wheeler; Thomas Walz; Robert E Kingston; James Gusella; Ronald A Conlon; Marcy E MacDonald
Huntingtin facilitates polycomb repressive complex 2.
Human molecular genetics 2010;19(4):573-83.
2010: Jong-Min Lee; Jie Zhang; Andrew I Su; John R Walker; Tim Wiltshire; Kihwa Kang; Ella Dragileva; Tammy Gillis; Edith T Lopez; Marie-Josee Boily; Michel Cyr; Isaac Kohane; James Gusella; Marcy E MacDonald; Vanessa C Wheeler
A novel approach to investigate tissue-specific trinucleotide repeat instability.
BMC systems biology 2010;4():29.
2009: Meera Swami; Audrey E Hendricks; Tammy Gillis; Tiffany Massood; Jayalakshmi Mysore; Richard H Myers; Vanessa C Wheeler
Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset.
Human molecular genetics 2009;18(16):3039-47.
2007: Vanessa C Wheeler; Francesca Persichetti; S M McNeil; Jayalakshmi Mysore; S S Mysore; Marcy E MacDonald; Richard H Myers; James Gusella; Nancy S Wexler
Factors associated with HD CAG repeat instability in Huntington disease.
Journal of medical genetics 2007;44(11):695-701.
2006: Paolo Guidetti; Gillian P Bates; Graham Kyrenia Rona; Michael R Hayden; Blair R Leavitt; Marcy E MacDonald; Elizabeth J Slow; Vanessa C Wheeler; Ben Woodman; Robert Schwarcz
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice.
Neurobiology of disease 2006;23(1):190-7.
2006: Alejandro Lloret; Ella Dragileva; Allison Teed; Janice A Espinola; Elisa Fossale; Tammy Gillis; Edith Lopez; Richard H Myers; Marcy E MacDonald; Vanessa C Wheeler
Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice.
Human molecular genetics 2006;15(12):2015-24.
2003: Silvia Gines; Ihn Sik Seong; Elisa Fossale; Elena Ivanova; Flavia Trettel; James Gusella; Vanessa C Wheeler; Francesca Persichetti; Marcy E MacDonald
Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice.
Human molecular genetics 2003;12(5):497-508.
2003: Vanessa C Wheeler; Lori-Anne Lebel; Vladimir Vrbanac; Allison Teed; Hein te Riele; Marcy E MacDonald
Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum.
Human molecular genetics 2003;12(3):273-81.
2003: Marcy E MacDonald; Silvia Gines; James Gusella; Vanessa C Wheeler
Huntington's disease.
Neuromolecular medicine 2003;4(1-2):7-20.
2003: B Joy Snider; J L Moss; F J Revilla; C-S Lee; Vanessa C Wheeler; Marcy E MacDonald; Dennis Choi
Neocortical neurons cultured from mice with expanded CAG repeats in the huntingtin gene: unaltered vulnerability to excitotoxins and other insults.
Neuroscience 2003;120(3):617-25.
2002: Shobu Namura; Lorenz Hirt; Vanessa C Wheeler; Kim M McGinnis; Paige Hilditch-Maguire; Michael A Moskowitz; Marcy E MacDonald; Francesca Persichetti
The HD mutation does not alter neuronal death in the striatum of Hdh(Q92) knock-in mice after mild focal ischemia.
Neurobiology of disease 2002;11(1):147-54.
2002: Elisa Fossale; Vanessa C Wheeler; Vladimir Vrbanac; Lori-Anne Lebel; Allison Teed; Jayalakshmi Mysore; James Gusella; Marcy E MacDonald; Francesca Persichetti
Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice.
Human molecular genetics 2002;11(19):2233-41.
2002: Vanessa C Wheeler; Claire-Anne Gutekunst; Vladimir Vrbanac; Lori-Anne Lebel; Gabriele Schilling; Steven M Hersch; Robert M Friedlander; James Gusella; Jean-Paul Vonsattel; David R Borchelt; Marcy E MacDonald
Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice.
Human molecular genetics 2002;11(6):633-40.
2001: Wojtek Auerbach; Marc S Hurlbert; Paige Hilditch-Maguire; Youssef Wadghiri; Vanessa C Wheeler; S I Cohen; Alexandra L Joyner; Marcy E MacDonald; Daniel Turnbull
The HD mutation causes progressive lethal neurological disease in mice expressing reduced levels of huntingtin.
Human molecular genetics 2001;10(22):2515-23.
2000: Flavia Trettel; Dorotea Rigamonti; Paige Hilditch-Maguire; Vanessa C Wheeler; A H Sharp; Francesca Persichetti; Elena Cattaneo; Marcy E MacDonald
Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells.
Human molecular genetics 2000;9(19):2799-809.
2000: Vanessa C Wheeler; JK White; Claire-Anne Gutekunst; Vladimir Vrbanac; M Weaver; Xiao-Jiang Li; S H Li; H Yi; Jean-Paul Vonsattel; James Gusella; Steven M Hersch; Wojtek Auerbach; Alexandra L Joyner; Marcy E MacDonald
Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice.
Human molecular genetics 2000;9(4):503-13.
1999: Vanessa C Wheeler; Wojtek Auerbach; JK White; J Srinidhi; A Auerbach; A Ryan; Mabel P Duyao; Vladimir Vrbanac; M Weaver; James Gusella; Alexandra L Joyner; Marcy E MacDonald
Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse.
Human molecular genetics 1999;8(1):115-22.