FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Anthony Whetton

Research Profile

Anatomy

Living Beings

Mouse

Chemicals & Drugs

Physiology

Co-author Network

Publications

TOP 3
K L Simpson; F Trapani; M J Walker; Anthony D Whetton; Kaye J Williams; C Zhou; G Brown; Christopher Cawthorne; M J Dawson; C L Hodgkinson; M Kadirvel; M Macfarlane; Caroline Dive
A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers.
Caroline A Evans; John R Griffiths; Richard D Unwin; Anthony D Whetton; Bernard M Corfe
Application of the MIDAS approach for analysis of lysine acetylation sites.
Stefan Balabanov; Mhairi Copland; Caroline A Evans; Francesca Pellicano; Michael J Walker; Anthony D Whetton; Sheela A Abraham; Tessa L Holyoake
Quantitative proteomics analysis of BMS-214662 effects on CD34 positive cells from chronic myeloid leukaemia patients.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Anthony Whetton (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: K L Simpson; F Trapani; M J Walker; Anthony D Whetton; Kaye J Williams; C Zhou; G Brown; Christopher Cawthorne; M J Dawson; C L Hodgkinson; M Kadirvel; M Macfarlane; Caroline Dive
A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers.
Cell death & disease 2013;4():e613.
2013: Caroline A Evans; John R Griffiths; Richard D Unwin; Anthony D Whetton; Bernard M Corfe
Application of the MIDAS approach for analysis of lysine acetylation sites.
Methods in molecular biology (Clifton, N.J.) 2013;981():25-36.
2013: Stefan Balabanov; Mhairi Copland; Caroline A Evans; Francesca Pellicano; Michael J Walker; Anthony D Whetton; Sheela A Abraham; Tessa L Holyoake
Quantitative proteomics analysis of BMS-214662 effects on CD34 positive cells from chronic myeloid leukaemia patients.
Proteomics 2013;13(1):153-68.
2013: Eva Rodríguez-Suárez; Anthony D Whetton
The application of quantification techniques in proteomics for biomedical research.
Mass spectrometry reviews 2013;32(1):1-26.
2012: François Griaud; Andrew Pierce; David N Potier; Elaine Spooncer; Samuel Taylor; Andrew J K Williamson; Anthony D Whetton
BCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response.
Journal of proteomics 2012;77():14-26.
2012: Stephanie Smetsers; Gordon Strathdee; Anthony D Whetton; Andrew M Will; Robert F Wynn; Joanne Muter; Leena Patel; Davy Rockx; Jonathan Shanks; Denise Bonney; Claire Bristow; Kate Chandler; Josephine C Dorsman; Johan J P Gille; Hans Joenje; Eva Klopocki; Stefan Meyer
Heterozygote FANCD2 mutations associated with childhood T Cell ALL and testicular seminoma.
Familial cancer 2012;11(4):661-5.
2012: Andrew A Vaughan; David C Wedge; Anthony D Whetton; J William Allwood; Fiona H Blackhall; Caroline Dive; Warwick B Dunn; Royston Goodacre
Liquid chromatography-mass spectrometry calibration transfer and metabolomics data fusion.
Analytical chemistry 2012;84(22):9848-57.
2012: Dung-Fang Lee; Francesca Aguilo; Yen-Sin Ang; Xonia Carvajal-Vergara; Betty Chang; Henia Darr; Elsa R Flores; Bruce D Gelb; Julian Gingold; Mien-Chie Hung; Avi Ma'ayan; Kateri A Moore; Sonia Mulero-Navarro; Xiaohong Niu; Carlos Filipe Pereira; Christoph Schaniel; Ana Sevilla; Yuh-Pyng Sher; Hans-Willem Snoeck; Jie Su; Hung-Liang Wang; Anthony D Whetton; Andrew J K Williamson; Ruiying Zhao; Ihor R Lemischka
Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling.
Cell stem cell 2012;11(2):179-94.
2012: David N Potier; Richard D Unwin; Michael J Walker; Emma Carrick; John R Griffiths; Andrew J K Willamson; Anthony D Whetton
An assessment of peptide enrichment methods employing mTRAQ quantification approaches.
Analytical chemistry 2012;84(13):5604-10.
2012: Cong Zhou; Martin J Dawson; Caroline Dive; Lee Lancashire; Patricia Price; Agata Rembielak; Kathryn L Simpson; Richard D Unwin; Michael J Walker; Catharine West; Anthony D Whetton
Statistical considerations of optimal study design for human plasma proteomics and biomarker discovery.
Journal of proteome research 2012;11(4):2103-13.
2012: Andrew Pierce; Toryn Poolman; David Ray; Elaine Spooncer; Sam Taylor; Richard D Unwin; Michael Walker; John R Griffiths; Ewa Jaworska; Mark Aspinall O'Dea; Andrew Williamson; Anthony D Whetton
Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation.
PloS one 2012;7(6):e38928.
2012: Sara Cadeco; Andrew J K Williamson; Anthony D Whetton
The use of proteomics for systematic analysis of normal and transformed hematopoietic stem cells.
Current pharmaceutical design 2012;18(13):1730-50.
2011: Sheetal Ramachandran; Christian Kardinal; Sabine Klebba-Faerber; Doan Duy Hai Tran; Anthony D Whetton; Teruko Tamura
An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.
RNA (New York, N.Y.) 2011;17(11):1957-66.
2011: Andrew J K Williamson; Anthony D Whetton
The requirement for proteomics to unravel stem cell regulatory mechanisms.
Journal of cellular physiology 2011;226(10):2478-83.
2011: David C Wedge; Anthony D Whetton; Lynsey Priest; Kathryn Simpson; Andrew A Vaughan; J William Allwood; Fiona H Blackhall; Marie Brown; Caroline Dive; Warwick Dunn; Royston Goodacre
Is serum or plasma more appropriate for intersubject comparisons in metabolomic studies? An assessment in patients with small-cell lung cancer.
Analytical chemistry 2011;83(17):6689-97.
2011: Stefan Meyer; Claire Bristow; Mark Wappett; Stuart Pepper; Anthony D Whetton; Helmut Hanenberg; Heidemarie Neitzel; Marcin W Wlodarski; Wolfram Ebell; Holger Tönnies
Fanconi anemia (FA)-associated 3q gains in leukemic transformation consistently target EVI1, but do not affect low TERC expression in FA.
Blood 2011;117(22):6047-50.
2011: Nicolas Bonadies; Samuel D Foster; Wai-In Chan; Brynn T Kvinlaug; Dominik Spensberger; Mark A Dawson; Elaine Spooncer; Anthony D Whetton; Andrew J Bannister; Brian J Huntly; Berthold Göttgens
Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemia.
PloS one 2011;6(1):e16330.
2010: Richard D Unwin; John R Griffiths; Anthony D Whetton
Simultaneous analysis of relative protein expression levels across multiple samples using iTRAQ isobaric tags with 2D nano LC-MS/MS.
Nature protocols 2010;5(9):1574-82.
2010: Chia Fang Lee; Stephen Griffiths; Eva Rodríguez-Suárez; Andrew Pierce; Richard D Unwin; Ewa Jaworska; Caroline A Evans; Simon J Gaskell; Anthony D Whetton
Assessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches.
Proteomics 2010;10(18):3321-42.
2010: Richard T Blankley; Nicola J Robinson; John D Aplin; Ian P Crocker; Simon J Gaskell; Anthony D Whetton; Philip N Baker; Jenny E Myers
A gel-free quantitative proteomics analysis of factors released from hypoxic-conditioned placentae.
Reproductive sciences (Thousand Oaks, Calif.) 2010;17(3):247-57.
2010: Karen S Rees-Unwin; Robin Faragher; Richard D Unwin; Julie Adams; Philip J Brown; Ann-Marie Buckle; Andrew Pettitt; Claire V Hutchinson; Suzanne M Johnson; Karen Pulford; Alison H Banham; Anthony D Whetton; Guy Lucas; David Y Mason; John Burthem
Ribosome-associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia.
British journal of haematology 2010;148(4):534-43.
2010: Annalisa Mancini; Susanne C Niemann-Seyde; Rüdiger Pankow; Omar El Bounkari; Sabine Klebba-Färber; Alexandra Koch; Ewa Jaworska; Elaine Spooncer; Achim D Gruber; Anthony D Whetton; Teruko Tamura
THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo.
BMC biology 2010;8():1.
2010: Andrew J K Williamson; Anthony D Whetton
Development of approaches for systematic analysis of protein networks in stem cells.
Advances in enzyme regulation 2010;50(1):273-84.
2009: Rong Lu; Florian Markowetz; Richard D Unwin; Jeffrey T Leek; Edoardo Airoldi; Ben D MacArthur; Alexander Lachmann; Roye Rozov; Avi Ma'ayan; Laurie A Boyer; Olga G Troyanskaya; Anthony D Whetton; Ihor R Lemischka
Systems-level dynamic analyses of fate change in murine embryonic stem cells.
Nature 2009;462(7271):358-62.
2009: Michael Leverentz; Robert N Campbell; Yvonne Connolly; Anthony D Whetton; Richard J Reece
Mutation of a phosphorylatable residue in Put3p affects the magnitude of rapamycin-induced PUT1 activation in a Gat1p-dependent manner.
The Journal of biological chemistry 2009;284(36):24115-22.
2009: Kathryn L Simpson; Anthony D Whetton; Caroline Dive
Quantitative mass spectrometry-based techniques for clinical use: biomarker identification and quantification.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(13):1240-9.
2009: Simon A Woodcock; Claire Rooney; Michalis Liontos; Yvonne Connolly; Vassilis Zoumpourlis; Anthony D Whetton; Vassilis G Gorgoulis; Angeliki Malliri
SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1.
Molecular cell 2009;33(5):639-53.
2009: Omar El Bounkari; Anuja Guria; Sabine Klebba-Faerber; Maike Claussen; Tomas Pieler; John R Griffiths; Anthony D Whetton; Alexandra Koch; Teruko Tamura
Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP).
FEBS letters 2009;583(1):13-8.
2009: Richard D Unwin; John R Griffiths; Anthony D Whetton
A sensitive mass spectrometric method for hypothesis-driven detection of peptide post-translational modifications: multiple reaction monitoring-initiated detection and sequencing (MIDAS).
Nature protocols 2009;4(6):870-7.
2008: Andrew Pierce; Louise Carney; Hajja G Hamza; John Griffiths; Liqun Zhang; Beth A Whetton; M Belen Gonzalez Sanchez; Teruko Tamura; David W Sternberg; Anthony D Whetton
THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover.
British journal of haematology 2008;141(5):641-50.
2008: Andrew Pierce; Richard D Unwin; Caroline A Evans; Stephen Griffiths; Louise Carney; Liqun Zhang; Ewa Jaworska; Chia-Fang Lee; David Blinco; Michal J Okoniewski; Crispin J Miller; Danny A Bitton; Elaine Spooncer; Anthony D Whetton
Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases.
Molecular & cellular proteomics : MCP 2008;7(5):853-63.
2008: Anthony D Whetton; Andrew J K Williamson; Jeroen Krijgsveld; Bong Hee Lee; Ihor Lemischka; Steve Oh; Martin Pera; Christine Mummery; Albert J R Heck
The time is right: proteome biology of stem cells.
Cell stem cell 2008;2(3):215-7.
2008: Elaine Spooncer; Nathalie Brouard; Susie K Nilsson; Brenda Williams; Mira C Liu; Richard D Unwin; David Blinco; Ewa Jaworska; Paul J Simmons; Anthony D Whetton
Developmental fate determination and marker discovery in hematopoietic stem cell biology using proteomic fingerprinting.
Molecular & cellular proteomics : MCP 2008;7(3):573-81.
2008: Andrew J K Williamson; Duncan Smith; David Blinco; Richard D Unwin; Stella Pearson; Claire Wilson; Crispin Miller; Lee Lancashire; Georges Lacaud; Valerie Kouskoff; Anthony D Whetton
Quantitative proteomics analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis.
Molecular & cellular proteomics : MCP 2008;7(3):459-72.
2008: Siân H Leech; Caroline A Evans; Leila Shaw; Chi H Wong; Joanne Connolly; John Griffiths; Anthony D Whetton; Bernard M Corfe
Proteomic analyses of intermediate filaments reveals cytokeratin8 is highly acetylated--implications for colorectal epithelial homeostasis.
Proteomics 2008;8(2):279-88.
2008: Jeroen Krijgsveld; Anthony D Whetton; Bonghee Lee; Ihor Lemischka; Steve Oh; Martin Pera; Christine Mummery; albert heck
Proteome biology of stem cells: a new joint HUPO and ISSCR initiative.
Molecular & cellular proteomics : MCP 2008;7(1):204-5.
2007: Arkadiusz Welman; John Griffiths; Anthony D Whetton; Caroline Dive
Protein kinase C delta is phosphorylated on five novel Ser/Thr sites following inducible overexpression in human colorectal cancer cells.
Protein science : a publication of the Protein Society 2007;16(12):2711-5.
2007: Richard D Unwin; Anthony D Whetton
How will haematologists use proteomics?
Blood reviews 2007;21(6):315-26.
2007: John Burthem; K Rees-Unwin; Rachel Mottram; J Adams; Guy S Lucas; Elaine Spooncer; Anthony D Whetton
The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells.
Leukemia 2007;21(8):1708-14.
2007: John Griffiths; Richard D Unwin; Caroline A Evans; Siân H Leech; Bernard M Corfe; Anthony D Whetton
The application of a hypothesis-driven strategy to the sensitive detection and location of acetylated lysine residues.
Journal of the American Society for Mass Spectrometry 2007;18(8):1423-8.
2007: Stephen D Griffiths; John Burthem; Richard D Unwin; Tessa L Holyoake; Junia V Melo; Guy S Lucas; Anthony D Whetton
The use of isobaric tag peptide labeling (iTRAQ) and mass spectrometry to examine rare, primitive hematopoietic cells from patients with chronic myeloid leukemia.
Molecular biotechnology 2007;36(2):81-9.
2007: Stefan Meyer; William Fergusson; Anthony D Whetton; Flavia Moreira-Leite; Stuart D Pepper; Crispin Miller; Emma K Saunders; Daniel J White; Andrew M Will; Tim O B Eden; Hideyuki Ikeda; Reinhard Ullmann; Seval Tuerkmen; Antje Gerlach; Eva Klopocki; Holger Tönnies
Amplification and translocation of 3q26 with overexpression of EVI1 in Fanconi anemia-derived childhood acute myeloid leukemia with biallelic FANCD1/BRCA2 disruption.
Genes, chromosomes & cancer 2007;46(4):359-72.
2007: Annalisa Mancini; Omar El Bounkari; A-F Norrenbrock; Michaela Scherr; D Schaefer; M Eder; A H Banham; Karen Pulford; L Lyne; Anthony D Whetton; Teruko Tamura
FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha.
Oncogene 2007;26(7):1020-7.
2006: Lynn McCallum; Susan Price; Nathalie Planque; Bernard Perbal; Andrew Pierce; Anthony D Whetton; Alexandra E Irvine
A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation.
Blood 2006;108(5):1716-23.
2006: Richard D Unwin; Anthony D Whetton
Systematic proteome and transcriptome analysis of stem cell populations.
Cell cycle (Georgetown, Tex.) 2006;5(15):1587-91.
2006: Anu Bashamboo; A Helen Taylor; Kay Samuel; Jean-Jacques Panthier; Anthony D Whetton; Lesley Forrester
The survival of differentiating embryonic stem cells is dependent on the SCF-KIT pathway.
Journal of cell science 2006;119(Pt 15):3039-46.
2006: Richard D Unwin; Caroline A Evans; Anthony D Whetton
Relative quantification in proteomics: new approaches for biochemistry.
Trends in biochemical sciences 2006;31(8):473-84.
2006: Richard D Unwin; Duncan Smith; David Blinco; Claire L Wilson; Crispin J Miller; Caroline A Evans; Ewa Jaworska; Stephen A Baldwin; Kay Barnes; Andrew Pierce; Elaine Spooncer; Anthony D Whetton
Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells.
Blood 2006;107(12):4687-94.
2006: Andrew Pierce; Yuning Lu; Hajja G Hamzah; Suzanne Thompson; P Jane Owen-Lynch; Anthony D Whetton; Elaine Spooncer
Differential effect of leukaemogenic tyrosine kinases on cell motility is governed by subcellular localisation.
British journal of haematology 2006;133(3):345-52.
2006: N Underhill-Day; Andrew Pierce; S E Thompson; Dia Xenaki; Anthony D Whetton; P Jane Owen-Lynch
Role of the C-terminal actin binding domain in BCR/ABL-mediated survival and drug resistance.
British journal of haematology 2006;132(6):774-83.
2006: Stacey Warwood; shabaz mohammed; Ileana M Cristea; Caroline Evans; Anthony D Whetton; Simon J Gaskell
Guanidination chemistry for qualitative and quantitative proteomics.
Rapid communications in mass spectrometry : RCM 2006;20(21):3245-56.
2005: Hajja G Hamzah; Andrew Pierce; W A Stewart; C Peter Downes; A Gray; A Irvine; Elaine Spooncer; Anthony D Whetton
Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib.
Leukemia 2005;19(10):1851-3.
2005: Richard D Unwin; John Griffiths; Michael Leverentz; Agnes Grallert; Iain M Hagan; Anthony D Whetton
Multiple reaction monitoring to identify sites of protein phosphorylation with high sensitivity.
Molecular & cellular proteomics : MCP 2005;4(8):1134-44.
2005: Richard D Unwin; Andrew Pierce; Rod B Watson; David W Sternberg; Anthony D Whetton
Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells.
Molecular & cellular proteomics : MCP 2005;4(7):924-35.
2005: Kay Barnes; Elizabeth McIntosh; Anthony D Whetton; George Q Daley; Johanne Bentley; Stephen A Baldwin
Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation.
Oncogene 2005;24(20):3257-67.
2005: Richard D Unwin; David W Sternberg; Yuning Lu; Andrew Pierce; D Gary Gilliland; Anthony D Whetton
Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: identification of the Rho pathway as a target of BCR/ABL.
The Journal of biological chemistry 2005;280(8):6316-26.
2004: Anthony D Whetton
Stem cells bank on ATM machine.
Nature medicine 2004;10(11):1166-8.
2004: Kevin L Garwood; Thomas McLaughlin; Christopher Garwood; Scott Joens; Norman Morrison; Christopher Taylor; Kathleen Carroll; Caroline Evans; Anthony D Whetton; Sarah Hart; David Stead; Zhikang Yin; Alistair J P Brown; Andy Hesketh; Keith F Chater; Lena Hansson; Muriel Mewissen; Peter Ghazal; Julie Howard; Kathryn S Lilley; Simon J Gaskell; Andrew Brass; Simon Hubbard; Stephen G Oliver; Norman W Paton
PEDRo: a database for storing, searching and disseminating experimental proteomics data.
BMC genomics 2004;5():68.
2004: Annalisa Mancini; Alexandra Koch; Anthony D Whetton; Teruko Tamura
The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation.
Oncogene 2004;23(39):6581-9.
2004: Caroline A Evans; Robert Tonge; David Blinco; Andrew Pierce; Joanne Shaw; Yuning Lu; Hajja G Hamzah; Alexander Gray; C Peter Downes; Simon J Gaskell; Elaine Spooncer; Anthony D Whetton
Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility.
Blood 2004;103(10):3751-9.
2004: Ileana M Cristea; Simon J Gaskell; Anthony D Whetton
Proteomics techniques and their application to hematology.
Blood 2004;103(10):3624-34.
2004: Dia Xenaki; Andrew Pierce; Nick Underhill-Day; Anthony D Whetton; P Jane Owen-Lynch
Bcr-Abl-mediated molecular mechanism for apoptotic suppression in multipotent haemopoietic cells: a role for PKCbetaII.
Cellular signalling 2004;16(2):145-56.
2003: Richard D Unwin; Simon J Gaskell; Caroline A Evans; Anthony D Whetton
The potential for proteomic definition of stem cell populations.
Experimental hematology 2003;31(12):1147-59.
2003: Duncan A E Cochran; Caroline A Evans; David Blinco; John Burthem; Freda K Stevenson; Simon J Gaskell; Anthony D Whetton
Proteomic analysis of chronic lymphocytic leukemia subtypes with mutated or unmutated Ig V(H) genes.
Molecular & cellular proteomics : MCP 2003;2(12):1331-41.
2003: Duncan Smith; John Burthem; Anthony D Whetton
Molecular pathogenesis of chronic myeloid leukaemia.
Expert reviews in molecular medicine 2003;5(27):1-27.
2003: Anthony D Whetton; Yuning Lu; Andrew Pierce; Louise Carney; Elaine Spooncer
Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1.
Blood 2003;102(8):2798-802.
2003: Johanne Bentley; Dalina Itchayanan; Kay Barnes; Elizabeth McIntosh; Xiuwen Tang; C Peter Downes; Geoffrey D Holman; Anthony D Whetton; P Jane Owen-Lynch; Stephen A Baldwin
Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface.
The Journal of biological chemistry 2003;278(41):39337-48.
2003: Candy Lee; Caroline A Evans; Elaine Spooncer; Andrew Pierce; Rachel Mottram; Anthony D Whetton
Generation of a conditionally immortalized myeloid progenitor cell line requiring the presence of both interleukin-3 and stem cell factor to survive and proliferate.
British journal of haematology 2003;122(6):985-95.
2002: Duncan Smith; Caroline A Evans; Andrew Pierce; Simon J Gaskell; Anthony D Whetton
Changes in the proteome associated with the action of Bcr-Abl tyrosine kinase are not related to transcriptional regulation.
Molecular & cellular proteomics : MCP 2002;1(11):876-84.
2002: Caroline A Evans; Shahrul Ariffin; Andrew Pierce; Anthony D Whetton
Identification of primary structural features that define the differential actions of IL-3 and GM-CSF receptors.
Blood 2002;100(9):3164-74.
2002: Andrew R S Ross; Peter J Lee; Duncan L Smith; James I Langridge; Anthony D Whetton; Simon J Gaskell
Identification of proteins from two-dimensional polyacrylamide gels using a novel acid-labile surfactant.
Proteomics 2002;2(7):928-36.
2002: Andrew Pierce; Elaine Spooncer; Shaun Ainsworth; Anthony D Whetton
BCR-ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor.
Oncogene 2002;21(19):3068-75.
2001: S J Khanna; R Brown; Anthony D Whetton; K L Ball; Caroline Dive
v-Abl protein-tyrosine kinase up-regulates p21WAF-1 in cell cycle arrested and proliferating myeloid cells.
The Journal of biological chemistry 2001;276(14):11143-50.
2001: Andrew Pierce; Duncan Smith; L V Jakobsen; Anthony D Whetton; Elaine Spooncer
The specific enhancement of interferon alpha induced growth inhibition by BCR/ABL only occurs in multipotent cells.
The hematology journal : the official journal of the European Haematology Association / EHA 2001;2(4):257-64.
2001: Johanne Bentley; Ian Walker; Elizabeth McIntosh; Anthony D Whetton; P Jane Owen-Lynch; Stephen A Baldwin
Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model.
British journal of haematology 2001;112(1):212-5.
2000: JM Francis; Clare Heyworth; Elaine Spooncer; Andrew Pierce; TM Dexter; Anthony D Whetton
Transforming growth factor-beta 1 induces apoptosis independently of p53 and selectively reduces expression of Bcl-2 in multipotent hematopoietic cells.
The Journal of biological chemistry 2000;275(50):39137-45.
2000: Andrew Pierce; Elaine Spooncer; S Wooley; Caroline Dive; JM Francis; Jaleel A Miyan; P Jane Owen-Lynch; TM Dexter; Anthony D Whetton
Bcr-Abl protein tyrosine kinase activity induces a loss of p53 protein that mediates a delay in myeloid differentiation.
Oncogene 2000;19(48):5487-97.
2000: Anne-Marie Buckle; Rachel Mottram; Andrew Pierce; Guy S Lucas; N Russell; Jaleel A Miyan; Anthony D Whetton
The effect of Bcr-Abl protein tyrosine kinase on maturation and proliferation of primitive haematopoietic cells.
Molecular medicine (Cambridge, Mass.) 2000;6(10):892-902.
2000: Xiuwen Tang; C Peter Downes; Anthony D Whetton; P Jane Owen-Lynch
Role of phosphatidylinositol 3-kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein-tyrosine kinase.
The Journal of biological chemistry 2000;275(17):13142-8.
2000: CS Broome; Anthony D Whetton; Jaleel A Miyan
Neuropeptide control of bone marrow neutrophil production is mediated by both direct and indirect effects on CFU-GM.
British journal of haematology 2000;108(1):140-50.
1999: Caroline A Evans; Andrew Pierce; S A Winter; Elaine Spooncer; Clare Heyworth; Anthony D Whetton
Activation of granulocyte-macrophage colony-stimulating factor and interleukin-3 receptor subunits in a multipotential hematopoietic progenitor cell line leads to differential effects on development.
Blood 1999;94(5):1504-14.
1999: Anthony D Whetton; G J Graham
Homing and mobilization in the stem cell niche.
Trends in cell biology 1999;9(6):233-8.
1999: SE Nicholls; G Lucas; G J Graham; N H Russell; Rachel Mottram; Anthony D Whetton; Anne-Marie Buckle
Macrophage-inflammatory protein-1alpha receptor expression on normal and chronic myeloid leukemia CD34+ cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):6191-9.
1999: SE Nicholls; S Winter; Rachel Mottram; Jaleel A Miyan; Anthony D Whetton
Flt3 ligand can promote survival and macrophage development without proliferation in myeloid progenitor cells.
Experimental hematology 1999;27(4):663-72.
1998: Anthony D Whetton; Elaine Spooncer
Role of cytokines and extracellular matrix in the regulation of haemopoietic stem cells.
Current opinion in cell biology 1998;10(6):721-6.
1998: Jaleel A Miyan; CS Broome; Anthony D Whetton
Neural regulation of bone marrow.
Blood 1998;92(8):2971-3.
1998: Andrew Pierce; P Jane Owen-Lynch; Elaine Spooncer; TM Dexter; Anthony D Whetton
p210 Bcr-Abl expression in a primitive multipotent haematopoietic cell line models the development of chronic myeloid leukaemia.
Oncogene 1998;17(5):667-72.
1998: P Jane Owen-Lynch; Lloyd Czaplewski; MG Hunter; Anthony D Whetton
The growth inhibitory role and potential clinical value of macrophage inflammatory protein 1 alpha in myeloid leukaemias.
Leukemia & lymphoma 1998;30(1-2):41-53.
1998: Andrew Pierce; Clare Heyworth; SE Nicholls; Elaine Spooncer; TM Dexter; J M Lord; P Jane Owen-Lynch; G Wark; Anthony D Whetton
An activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks macrophage colony-stimulating factor-stimulated signaling events.
The Journal of cell biology 1998;140(6):1511-8.
1998: G Wark; Clare Heyworth; Elaine Spooncer; Lloyd Czaplewski; JM Francis; TM Dexter; Anthony D Whetton
Abl protein kinase abrogates the response of multipotent haemopoietic cells to the growth inhibitor macrophage inflammatory protein-1 alpha.
Oncogene 1998;16(10):1319-24.
1998: Andrew Pierce; Anthony D Whetton; P Jane Owen-Lynch; J Tavernier; Elaine Spooncer; TM Dexter; Clare Heyworth
Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line.
Journal of cell science 1998;111 ( Pt 6)():815-23.
1998: M A Pearson; A M O'Farrell; TM Dexter; Anthony D Whetton; P Jane Owen-Lynch; Clare Heyworth
Investigation of the molecular mechanisms underlying growth factor synergy: the role of ERK 2 activation in synergy.
Growth factors (Chur, Switzerland) 1998;15(4):293-306.
1997: A M Afan; CS Broome; SE Nicholls; Anthony D Whetton; Jaleel A Miyan
Bone marrow innervation regulates cellular retention in the murine haemopoietic system.
British journal of haematology 1997;98(3):569-77.
1997: A Pierce; Anthony D Whetton
Haemopoietic growth factors and leukaemogenesis.
Biochemical Society transactions 1997;25(2):366-70.
1997: Q Chen; R S P Benson; Anthony D Whetton; Steven R Brant; Mark Donowitz; MH Montrose; Caroline Dive; Alastair J M Watson
Role of acid/base homeostasis in the suppression of apoptosis in haemopoietic cells by v-Abl protein tyrosine kinase.
Journal of cell science 1997;110 ( Pt 3)():379-87.
1996: P Jane Owen-Lynch; JA Adams; ML Brereton; Lloyd Czaplewski; Anthony D Whetton; John A Liu Yin
The effect of the chemokine rhMIP-1 alpha, and a non-aggregating variant BB-10010, on blast cells from patients with acute myeloid leukaemia.
British journal of haematology 1996;95(1):77-84.
1995: R C Chasty; G S Lucas; P Jane Owen-Lynch; Andrew Pierce; Anthony D Whetton
Macrophage inflammatory protein-1 alpha receptors are present on cells enriched for CD34 expression from patients with chronic myeloid leukemia.
Blood 1995;86(11):4270-7.
1995: Clare Heyworth; M Alauldin; Michael Cross; Leslie J Fairbairn; TM Dexter; Anthony D Whetton
Erythroid development of the FDCP-Mix A4 multipotent cell line is governed by the relative concentrations of erythropoietin and interleukin 3.
British journal of haematology 1995;91(1):15-22.
1995: R S Chapman; Anthony D Whetton; CM Chresta; Caroline Dive
Characterization of drug resistance mediated via the suppression of apoptosis by Abelson protein tyrosine kinase.
Molecular pharmacology 1995;48(2):334-43.
1995: S E Nicholls; Clare Heyworth; T M Dexter; J M Lord; G D Johnson; Anthony D Whetton
IL-4 promotes macrophage development by rapidly stimulating lineage restriction of bipotent granulocyte-macrophage colony-forming cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(2):845-53.
1995: C A Evans; J M Lord; P Jane Owen-Lynch; G Johnson; Caroline Dive; Anthony D Whetton
Suppression of apoptosis by v-ABL protein tyrosine kinase is associated with nuclear translocation and activation of protein kinase C in an interleukin-3-dependent haemopoietic cell line.
Journal of cell science 1995;108 ( Pt 7)():2591-8.
1995: R S Chapman; CM Chresta; A A Herberg; H M Beere; S Heer; Anthony D Whetton; John A Hickman; Caroline Dive
Further characterisation of the in situ terminal deoxynucleotidyl transferase (TdT) assay for the flow cytometric analysis of apoptosis in drug resistant and drug sensitive leukaemic cells.
Cytometry 1995;20(3):245-56.
1995: P Jane Owen-Lynch; A K Wong; Anthony D Whetton
v-Abl-mediated apoptotic suppression is associated with SHC phosphorylation without concomitant mitogen-activated protein kinase activation.
The Journal of biological chemistry 1995;270(11):5956-62.
1995: Clare Heyworth; M A Pearson; TM Dexter; G Wark; P Jane Owen-Lynch; Anthony D Whetton
Macrophage inflammatory protein-1 alpha mediated growth inhibition in a haemopoietic stem cell line is associated with inositol 1,4,5 triphosphate generation.
Growth factors (Chur, Switzerland) 1995;12(3):165-72.
1994: Clare Heyworth; TM Dexter; S E Nicholls; Anthony D Whetton
Combinations of colony-stimulating factors promote enhanced proliferative potential in enriched granulocyte-macrophage colony-forming cells.
Experimental hematology 1994;22(11):1089-94.
1994: R S Chapman; Anthony D Whetton; Caroline Dive
The suppression of drug-induced apoptosis by activation of v-ABL protein tyrosine kinase.
Cancer research 1994;54(19):5131-7.
1994: O Kan; Stephen A Baldwin; Anthony D Whetton
Apoptosis is regulated by the rate of glucose transport in an interleukin 3 dependent cell line.
The Journal of experimental medicine 1994;180(3):917-23.
1994: Stephen A Baldwin; O Kan; Anthony D Whetton; Sally Martin; H A Fawcett; D J Flint; C J Wilde
Regulation of the glucose transporter GLUT1 in mammalian cells.
Biochemical Society transactions 1994;22(3):814-7.
1994: O Kan; Stephen A Baldwin; Anthony D Whetton
Apoptosis is regulated by the rate of glucose transport in an IL-3-dependent haemopoietic cell line.
Biochemical Society transactions 1994;22(3):275S.
1994: Anthony D Whetton; Clare Heyworth; SE Nicholls; C A Evans; J M Lord; TM Dexter; P Jane Owen-Lynch
Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells.
The Journal of cell biology 1994;125(3):651-9.
1994: Elaine Spooncer; Leslie J Fairbairn; G J Cowling; TM Dexter; Anthony D Whetton; P Jane Owen-Lynch
Biological consequences of p160v-abl protein tyrosine kinase activity in a primitive, multipotent haemopoietic cell line.
Leukemia 1994;8(4):620-30.
1993: P J Owen; P Musk; C A Evans; Anthony D Whetton
Cellular signaling events elicited by v-abl associated with growth factor independence in an interleukin-3-dependent cell line.
The Journal of biological chemistry 1993;268(21):15696-703.
1993: C A Evans; P Jane Owen-Lynch; Anthony D Whetton; Caroline Dive
Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells.
Cancer research 1993;53(8):1735-8.
1993: Clare Heyworth; TM Dexter; S E Nicholls; Anthony D Whetton
Protein kinase C activators can interact synergistically with granulocyte colony-stimulating factor or interleukin-6 to stimulate colony formation from enriched granulocyte-macrophage colony-forming cells.
Blood 1993;81(4):894-900.
1992: Clare Heyworth; Anthony D Whetton; S Nicholls; Krisztina Maria Zsebo; TM Dexter
Stem cell factor directly stimulates the development of enriched granulocyte-macrophage colony-forming cells and promotes the effects of other colony-stimulating factors.
Blood 1992;80(9):2230-6.
1992: A A Akinsanya; Anthony D Whetton
IL-3 stimulated haemopoietic stem cell proliferation: evidence for G protein independent mitogenic signalling events.
Journal of cellular physiology 1992;152(2):245-52.
1992: O Kan; C A Evans; Anthony D Whetton
Cellular signalling events stimulated by myeloid haemopoietic growth factors.
Baillière's clinical haematology 1992;5(3):653-79.
1991: O Kan; Clare Heyworth; TM Dexter; P J Maudsley; N Cook; S J Vallance; Anthony D Whetton
Interferon-gamma stimulates the survival and influences the development of bipotential granulocyte-macrophage colony-forming cells.
Blood 1991;78(10):2588-94.
1991: S J Vallance; Anthony D Whetton
Control of proliferation by myeloid growth factors.
Biochemical Society transactions 1991;19(2):307-15.
1991: Clare Heyworth; J Hampson; TM Dexter; F Walker; A W Burgess; O Kan; N Cook; S J Vallance; Anthony D Whetton
Development of multipotential haemopoietic stem cells to neutrophils is associated with increased expression of receptors for granulocyte macrophage colony-stimulating factor: altered biological responses to GM-CSF during development.
Growth factors (Chur, Switzerland) 1991;5(2):87-98.
1991: Anthony D Whetton; S J Vallance
Regulation of neutrophil and macrophage production by growth factors.
The International journal of biochemistry 1991;23(12):1361-7.
1991: S J Vallance; C H MacPhee; C P Downes; Anthony D Whetton
Chemotactic peptides but not macrophage colony stimulating factor effect the synthesis of inositol lipids in macrophages.
Growth factors (Chur, Switzerland) 1991;4(3):175-81.
1990: Anthony D Whetton
The biology and clinical potential of growth factors that regulate myeloid cell production.
Trends in pharmacological sciences 1990;11(7):285-9.
1990: S J Vallance; C P Downes; E J Cragoe; Anthony D Whetton
Granulocyte-macrophage colony-stimulating factor can stimulate macrophage proliferation via persistent activation of Na+/H+ antiport. Evidence for two distinct roles for Na+/H+ antiport activation.
The Biochemical journal 1990;265(2):359-64.
1990: Anthony D Whetton
Regulation of haemopoietic cell development by growth factors.
Cellular signalling 1990;2(4):323-8.
1990: Clare Heyworth; S J Vallance; Anthony D Whetton; TM Dexter
The biochemistry and biology of the myeloid haemopoietic cell growth factors.
Journal of cell science. Supplement 1990;13():57-74.
1990: Clare Heyworth; TM Dexter; O Kan; Anthony D Whetton
The role of hemopoietic growth factors in self-renewal and differentiation of IL-3-dependent multipotential stem cells.
Growth factors (Chur, Switzerland) 1990;2(2-3):197-211.
1989: Anthony D Whetton; TM Dexter
Myeloid haemopoietic growth factors.
Biochimica et biophysica acta 1989;989(2):111-32.
1989: N Cook; TM Dexter; B I Lord; E J Cragoe; Anthony D Whetton
Identification of a common signal associated with cellular proliferation stimulated by four haemopoietic growth factors in a highly enriched population of granulocyte/macrophage colony-forming cells.
The EMBO journal 1989;8(10):2967-74.
1988: Anthony D Whetton; S J Vallance; Peter N Monk; E J Cragoe; TM Dexter; Clare Heyworth
Interleukin-3-stimulated haemopoietic stem cell proliferation. Evidence for activation of protein kinase C and Na+/H+ exchange without inositol lipid hydrolysis.
The Biochemical journal 1988;256(2):585-92.
1988: Anthony D Whetton; S J Huang; Peter N Monk
Adenosine triphosphate can maintain multipotent haemopoietic stem cells in the absence of interleukin 3 via a membrane permeabilization mechanism.
Biochemical and biophysical research communications 1988;152(3):1173-8.
1988: Anthony D Whetton; Peter N Monk; S D Consalvey; S J Huang; TM Dexter; C P Downes
Interleukin 3 stimulates proliferation via protein kinase C activation without increasing inositol lipid turnover.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3284-8.
1988: S J Huang; Peter N Monk; C P Downes; Anthony D Whetton
Platelet-activating factor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate stimulates the production of reactive oxygen intermediates in macrophages.
The Biochemical journal 1988;249(3):839-45.
1986: Anthony D Whetton; Peter N Monk; S D Consalvey; C P Downes
The haemopoietic growth factors interleukin 3 and colony stimulating factor-1 stimulate proliferation but do not induce inositol lipid breakdown in murine bone-marrow-derived macrophages.
The EMBO journal 1986;5(12):3281-6.
1985: T M Dexter; Anthony D Whetton; Elaine Spooncer; C Heyworth; P Simmons
The role of stromal cells and growth factors in haemopoiesis and modulation of their effects by the src oncogene.
Journal of cell science. Supplement 1985;3():83-95.