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David White

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Andrew Wellman; James Butler; Bradley A Edwards; Andrew C Jackson; Atul Malhotra; Shamim Nemati; Robert L Owens; Chris L Passaglia; Scott A Sands; David P White
A simplified method for determining phenotypic traits in patients with obstructive sleep apnea.
Bradley A Edwards; Lisa M Campana; James G Connolly; Scott A Sands; John A Trinder; Andrew Wellman; David P White; Atul Malhotra
Acetazolamide attenuates the ventilatory response to arousal in patients with obstructive sleep apnea.
Robert L Owens; Scott A Sands; David P White; James P Butler; Danny J Eckert; Bradley A Edwards; Atul Malhotra; Andrew Wellman
Upper airway collapsibility and patterns of flow limitation at constant end-expiratory lung volume.

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All Publications

2013: Andrew Wellman; James Butler; Bradley A Edwards; Andrew C Jackson; Atul Malhotra; Shamim Nemati; Robert L Owens; Chris L Passaglia; Scott A Sands; David P White
A simplified method for determining phenotypic traits in patients with obstructive sleep apnea.
Journal of applied physiology (Bethesda, Md. : 1985) 2013;114(7):911-22.
2013: Bradley A Edwards; Lisa M Campana; James G Connolly; Scott A Sands; John A Trinder; Andrew Wellman; David P White; Atul Malhotra
Acetazolamide attenuates the ventilatory response to arousal in patients with obstructive sleep apnea.
Sleep 2013;36(2):281-5.
2012: Robert L Owens; Scott A Sands; David P White; James P Butler; Danny J Eckert; Bradley A Edwards; Atul Malhotra; Andrew Wellman
Upper airway collapsibility and patterns of flow limitation at constant end-expiratory lung volume.
Journal of applied physiology (Bethesda, Md. : 1985) 2012;113(5):691-9.
2012: Christian L Nicholas; Julian P Saboisky; David P White; Christopher J Worsnop; Bei Bei; Danny J Eckert; Leila Heckel; Amy S Jordan; Atul Malhotra; John Trinder
Discharge patterns of human tensor palatini motor units during sleep onset.
Sleep 2012;35(5):699-707.
2012: Bradley A Edwards; Atul Malhotra; Robert L Owens; Scott A Sands; James P Butler; Danny J Eckert; David P White; Andrew Wellman
Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea.
The Journal of physiology 2012;590(Pt 5):1199-211.
2012: Julian P Saboisky; Daniel W Stashuk; John Trinder; David P White; Lisa M Campana; Andrea L Carusona; William S David; Danny J Eckert; Andrew Hamilton-Wright; Amy S Jordan; David G McSharry; Sanjeev Nandedkar; Atul Malhotra
Neurogenic changes in the upper airway of patients with obstructive sleep apnea.
American journal of respiratory and critical care medicine 2012;185(3):322-9.
2011: Bradley A Edwards; David P White
Control of the pharyngeal musculature during wakefulness and sleep: implications in normal controls and sleep apnea.
Head & neck 2011;33 Suppl 1():S37-45.
2010: Julian P Saboisky; Amy S Jordan; Danny J Eckert; David P White; John A Trinder; Christian L Nicholas; Shiva Gautam; Atul Malhotra
Recruitment and rate-coding strategies of the human genioglossus muscle.
Journal of applied physiology (Bethesda, Md. : 1985) 2010;109(6):1939-49.
2010: Christian L Nicholas; Bei Bei; Christopher Worsnop; Atul Malhotra; Amy S Jordan; Julian P Saboisky; Julia K M Chan; Ella Duckworth; David P White; John Trinder
Motor unit recruitment in human genioglossus muscle in response to hypercapnia.
Sleep 2010;33(11):1529-38.
2010: Amy S Jordan; David P White; Robert L Owens; Danny J Eckert; Shilpa Rahangdale; Susie Yim-Yeh; Atul Malhotra
The effect of increased genioglossus activity and end-expiratory lung volume on pharyngeal collapse.
Journal of applied physiology (Bethesda, Md. : 1985) 2010;109(2):469-75.
2010: Danny J Eckert; Julian P Saboisky; Amy S Jordan; David P White; Atul Malhotra
A secondary reflex suppression phase is present in genioglossus but not tensor palatini in response to negative upper airway pressure.
Journal of applied physiology (Bethesda, Md. : 1985) 2010;108(6):1619-24.
2010: Vanessa Wilkinson; Atul Malhotra; Christian L Nicholas; Christopher J Worsnop; Amy S Jordan; Jane E Butler; Julian P Saboisky; Simon C Gandevia; David P White; John Trinder
Discharge patterns of human genioglossus motor units during arousal from sleep.
Sleep 2010;33(3):379-87.
2010: Robert L Owens; Atul Malhotra; Danny J Eckert; David P White; Amy S Jordan
The influence of end-expiratory lung volume on measurements of pharyngeal collapsibility.
Journal of applied physiology (Bethesda, Md. : 1985) 2010;108(2):445-51.
2009: David P White
Auto-PEEP to treat obstructive sleep apnea.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2009;5(6):538-9.
2009: David P White
Opioid-induced suppression of genioglossal muscle activity: is it clinically important?
The Journal of physiology 2009;587(Pt 14):3421-2.
2009: Danny J Eckert; Atul Malhotra; Yu-Lun Lo; David P White; Amy S Jordan
The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep.
Chest 2009;135(4):957-64.
2009: Amy S Jordan; David P White; Yu-Lun Lo; Andrew Wellman; Danny J Eckert; Susie Yim-Yeh; Matthias Eikermann; Scott A Smith; Karen E Stevenson; Atul Malhotra
Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea.
Sleep 2009;32(3):361-8.
2008: Andrew Wellman; Atul Malhotra; Amy S Jordan; Karen E Stevenson; Shiva Gautam; David P White
Effect of oxygen in obstructive sleep apnea: role of loop gain.
Respiratory physiology & neurobiology 2008;162(2):144-51.
2008: Raphael C Heinzer; David P White; Amy S Jordan; Yu-Lun Lo; Louise Dover; K Stevenson; Atul Malhotra
Trazodone increases arousal threshold in obstructive sleep apnoea.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;31(6):1308-12.
2008: Vanessa Wilkinson; Atul Malhotra; Christian L Nicholas; Christopher J Worsnop; Amy S Jordan; Jane E Butler; Julian P Saboisky; Simon C Gandevia; David P White; John Trinder
Discharge patterns of human genioglossus motor units during sleep onset.
Sleep 2008;31(4):525-33.
2008: Raphael C Heinzer; David P White; Atul Malhotra; Yu-Lun Lo; Louise Dover; Karen E Stevenson; Amy S Jordan
Effect of expiratory positive airway pressure on sleep disordered breathing.
Sleep 2008;31(3):429-32.
2008: Mary MacDonald; James Fang; Steven D Pittman; David P White; Atul Malhotra
The current prevalence of sleep disordered breathing in congestive heart failure patients treated with beta-blockers.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2008;4(1):38-42.
2007: Matthias Eikermann; Philipp Fassbender; Shiva Gautam; Amy S Jordan; Shigeto Kubo; Atul Malhotra; Masaya Takahashi; David P White; Nancy L Chamberlin
Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function.
Anesthesiology 2007;107(4):621-9.
2007: Amy S Jordan; Andrew Wellman; Raphael C Heinzer; Yu-Lun Lo; Karen Schory; Louise Dover; Shiva Gautam; Atul Malhotra; David P White
Mechanisms used to restore ventilation after partial upper airway collapse during sleep in humans.
Thorax 2007;62(10):861-7.
2007: Yu-Lun Lo; Amy S Jordan; Atul Malhotra; Andrew Wellman; Raphael A Heinzer; Matthias Eikermann; Karen Schory; Louise Dover; David P White
Influence of wakefulness on pharyngeal airway muscle activity.
Thorax 2007;62(9):799-805.
2007: David P White
Long-term facilitation (LTF) and obstructive sleep apnea.
Respiratory physiology & neurobiology 2007;158(1):112-3.
2007: Matthias Eikermann; Amy S Jordan; Nancy L Chamberlin; Shiva Gautam; Andrew Wellman; Yu-Lun Lo; David P White; Atul Malhotra
The influence of aging on pharyngeal collapsibility during sleep.
Chest 2007;131(6):1702-9.
2007: Andrew Wellman; Atul Malhotra; Amy S Jordan; Karen Schory; Shiva Gautam; David P White
Chemical control stability in the elderly.
The Journal of physiology 2007;581(Pt 1):291-8.
2007: Nancy L Chamberlin; Matthias Eikermann; Philipp Fassbender; David P White; Atul Malhotra
Genioglossus premotoneurons and the negative pressure reflex in rats.
The Journal of physiology 2007;579(Pt 2):515-26.
2006: Stephen D Pittman; Giora Pillar; Richard B Berry; Atul Malhotra; Mary M MacDonald; David P White
Follow-up assessment of CPAP efficacy in patients with obstructive sleep apnea using an ambulatory device based on peripheral arterial tonometry.
Sleep & breathing = Schlaf & Atmung 2006;10(3):123-31.
2006: John Trinder; Clare Ivens; Jan Kleiman; Darci Kleverlaan; David P White
The cardiorespiratory activation response at an arousal from sleep is independent of the level of CO(2).
Journal of sleep research 2006;15(2):174-82.
2006: Raphael C Heinzer; Michael L Stanchina; Atul Malhotra; Amy S Jordan; Sanjay R Patel; Yu-Lun Lo; Andrew Wellman; Karen Schory; Louise Dover; David P White
Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea.
Thorax 2006;61(5):435-9.
2006: Eliot S Katz; Carole L Marcus; David P White
Influence of airway pressure on genioglossus activity during sleep in normal children.
American journal of respiratory and critical care medicine 2006;173(8):902-9.
2006: Chang-Kook Yang; Amy S Jordan; David P White; John W Winkelman
Heart rate response to respiratory events with or without leg movements.
Sleep 2006;29(4):553-6.
2006: Yu-Lun Lo; Amy S Jordan; Atul Malhotra; Andrew Wellman; Raphael C Heinzer; Karen Schory; Louise Dover; Robert B Fogel; David P White
Genioglossal muscle response to CO2 stimulation during NREM sleep.
Sleep 2006;29(4):470-7.
2006: Atul Malhotra; Yaqi Huang; Robert B Fogel; Stan Lazic; Giora Pillar; Marianna Jakab; Ron Kikinis; David P White
Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse.
The American journal of medicine 2006;119(1):72.e9-14.
2005: David P White
Pathogenesis of obstructive and central sleep apnea.
American journal of respiratory and critical care medicine 2005;172(11):1363-70.
2005: Amy S Jordan; Andrew Wellman; Jill K Edwards; Karen Schory; Louise Dover; Mary MacDonald; Sanjay R Patel; Robert B Fogel; Atul Malhotra; David P White
Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;99(5):2020-7.
2005: Changkook Yang; David P White; John W Winkelman
Antidepressants and periodic leg movements of sleep.
Biological psychiatry 2005;58(6):510-4.
2005: Michelle McGuire; Yi Zhang; David P White; Liming Ling
Phrenic long-term facilitation requires NMDA receptors in the phrenic motonucleus in rats.
The Journal of physiology 2005;567(Pt 2):599-611.
2005: Yaqi Huang; Atul Malhotra; David P White
Computational simulation of human upper airway collapse using a pressure-/state-dependent model of genioglossal muscle contraction under laminar flow conditions.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;99(3):1138-48.
2005: Raphael C Heinzer; Michael L Stanchina; Atul Malhotra; Robert B Fogel; Sanjay R Patel; Amy S Jordan; Karen Schory; David P White
Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea.
American journal of respiratory and critical care medicine 2005;172(1):114-7.
2005: Robert B Fogel; John Trinder; David P White; Atul Malhotra; Jill Raneri; Karen Schory; Darci Kleverlaan; Robert J Pierce
The effect of sleep onset on upper airway muscle activity in patients with sleep apnoea versus controls.
The Journal of physiology 2005;564(Pt 2):549-62.
2005: Naoko Tachibana; Najib T Ayas; David P White
A quantitative assessment of sleep laboratory activity in the United States.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2005;1(1):23-6.
2004: Jan Hedner; Giora Pillar; Stephen D Pittman; Ding Zou; Ludger Grote; David P White
A novel adaptive wrist actigraphy algorithm for sleep-wake assessment in sleep apnea patients.
Sleep 2004;27(8):1560-6.
2004: Andrew Wellman; Amy S Jordan; Atul Malhotra; Robert B Fogel; Eliot S Katz; Karen Schory; Jill K Edwards; David P White
Ventilatory control and airway anatomy in obstructive sleep apnea.
American journal of respiratory and critical care medicine 2004;170(11):1225-32.
2004: Stephen D Pittman; Mary M MacDonald; Robert B Fogel; Atul Malhotra; Koby Todros; Baruch Levy; Amir B Geva; David P White
Assessment of automated scoring of polysomnographic recordings in a population with suspected sleep-disordered breathing.
Sleep 2004;27(7):1394-403.
2004: Atul Malhotra; John Trinder; Robert B Fogel; Michael L Stanchina; Sanjay R Patel; Karen Schory; Darci Kleverlaan; David P White
Postural effects on pharyngeal protective reflex mechanisms.
Sleep 2004;27(6):1105-12.
2004: Eliot S Katz; David P White
Genioglossus activity during sleep in normal control subjects and children with obstructive sleep apnea.
American journal of respiratory and critical care medicine 2004;170(5):553-60.
2004: Stephen D Pittman; Najib T Ayas; Mary M MacDonald; Atul Malhotra; Robert B Fogel; David P White
Using a wrist-worn device based on peripheral arterial tonometry to diagnose obstructive sleep apnea: in-laboratory and ambulatory validation.
Sleep 2004;27(5):923-33.
2004: Amy S Jordan; R Doug Mcevoy; Jill K Edwards; Karen Schory; Chang-Kook Yang; Peter G Catcheside; Robert B Fogel; Atul Malhotra; David P White
The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans.
The Journal of physiology 2004;558(Pt 3):993-1004.
2004: Yi Zhang; Michelle McGuire; David P White; Liming Ling
Serotonin receptor subtypes involved in vagus nerve stimulation-induced phrenic long-term facilitation in rats.
Neuroscience letters 2004;363(2):108-11.
2004: Sanjay R Patel; Najib T Ayas; Mark R Malhotra; David P White; Eva S Schernhammer; Frank E Speizer; Meir J Stampfer; Frank B Hu
A prospective study of sleep duration and mortality risk in women.
Sleep 2004;27(3):440-4.
2004: Robert B Fogel; Atul Malhotra; David P White
Sleep. 2: pathophysiology of obstructive sleep apnoea/hypopnoea syndrome.
Thorax 2004;59(2):159-63.
2004: Michelle McGuire; Yi Zhang; David P White; Liming Ling
Serotonin receptor subtypes required for ventilatory long-term facilitation and its enhancement after chronic intermittent hypoxia in awake rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;286(2):R334-41.
2003: Robert B Fogel; David P White; Robert J Pierce; Atul Malhotra; Jill K Edwards; Judy Dunai; Darci Kleverlaan; John Trinder
Control of upper airway muscle activity in younger versus older men during sleep onset.
The Journal of physiology 2003;553(Pt 2):533-44.
2003: Michael L Stanchina; Atul Malhotra; Robert B Fogel; John Trinder; Jill K Edwards; Karen Schory; David P White
The influence of lung volume on pharyngeal mechanics, collapsibility, and genioglossus muscle activation during sleep.
Sleep 2003;26(7):851-6.
2003: Amy S Jordan; David P White; Robert B Fogel
Recent advances in understanding the pathogenesis of obstructive sleep apnea.
Current opinion in pulmonary medicine 2003;9(6):459-64.
2003: Michelle McGuire; Yi Zhang; David P White; Liming Ling
Chronic intermittent hypoxia enhances ventilatory long-term facilitation in awake rats.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;95(4):1499-508.
2003: Yi Zhang; Michelle McGuire; David P White; Liming Ling
Episodic phrenic-inhibitory vagus nerve stimulation paradoxically induces phrenic long-term facilitation in rats.
The Journal of physiology 2003;551(Pt 3):981-91.
2003: Eliot S Katz; David P White
Genioglossus activity in children with obstructive sleep apnea during wakefulness and sleep onset.
American journal of respiratory and critical care medicine 2003;168(6):664-70.
2003: Najib T Ayas; Stephen D Pittman; Mary MacDonald; David P White
Assessment of a wrist-worn device in the detection of obstructive sleep apnea.
Sleep medicine 2003;4(5):435-42.
2003: Robert B Fogel; John Trinder; Atul Malhotra; Michael L Stanchina; Jill K Edwards; Karen Schory; David P White
Within-breath control of genioglossal muscle activation in humans: effect of sleep-wake state.
The Journal of physiology 2003;550(Pt 3):899-910.
2003: Richard B Berry; David P White; John Roper; Giora Pillar; Robert B Fogel; Michael L Stanchina; Atul Malhotra
Awake negative pressure reflex response of the genioglossus in OSA patients and normal subjects.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;94(5):1875-82.
2003: Robert B Fogel; Atul Malhotra; Georgia Dalagiorgou; Malcolm K Robinson; Marianna Jakab; Ron Kikinis; Stephen D Pittman; David P White
Anatomic and physiologic predictors of apnea severity in morbidly obese subjects.
Sleep 2003;26(2):150-5.
2003: Sanjay R Patel; David P White; Atul Malhotra; Michael L Stanchina; Najib T Ayas
Continuous positive airway pressure therapy for treating sleepiness in a diverse population with obstructive sleep apnea: results of a meta-analysis.
Archives of internal medicine 2003;163(5):565-71.
2003: Najib T Ayas; David P White; Wael K Al-Delaimy; JoAnn E Manson; Meir J Stampfer; Frank E Speizer; Sanjay Patel; Frank B Hu
A prospective study of self-reported sleep duration and incident diabetes in women.
Diabetes care 2003;26(2):380-4.
2003: Andrew Wellman; Atul Malhotra; Robert B Fogel; Jill K Edwards; Karen Schory; David P White
Respiratory system loop gain in normal men and women measured with proportional-assist ventilation.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;94(1):205-12.
2002: Michelle McGuire; Yi Zhang; David P White; Liming Ling
Effect of hypoxic episode number and severity on ventilatory long-term facilitation in awake rats.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;93(6):2155-61.
2002: Atul Malhotra; Yaqi Huang; Robert B Fogel; Giora Pillar; Jill K Edwards; Ron Kikinis; Stephen H Loring; David P White
The male predisposition to pharyngeal collapse: importance of airway length.
American journal of respiratory and critical care medicine 2002;166(10):1388-95.
2002: Andrew Wellman; Atul Malhotra; David P White
Atrial pacing in sleep apnea syndrome.
The New England journal of medicine 2002;347(6):445-6; author reply 445-6.
2002: Michael L Stanchina; Atul Malhotra; Robert B Fogel; Najib T Ayas; Jill K Edwards; Karen Schory; David P White
Genioglossus muscle responsiveness to chemical and mechanical stimuli during non-rapid eye movement sleep.
American journal of respiratory and critical care medicine 2002;165(7):945-9.
2002: Atul Malhotra; Giora Pillar; Robert B Fogel; Jill K Edwards; Najib T Ayas; Toshiki Akahoshi; Dean Hess; David P White
Pharyngeal pressure and flow effects on genioglossus activation in normal subjects.
American journal of respiratory and critical care medicine 2002;165(1):71-7.
2001: Robert B Fogel; A Malhotra; Giora Pillar; Jill K Edwards; J Beauregard; Steven A Shea; David P White
Genioglossal activation in patients with obstructive sleep apnea versus control subjects. Mechanisms of muscle control.
American journal of respiratory and critical care medicine 2001;164(11):2025-30.
2001: Giora Pillar; Robert B Fogel; A Malhotra; J Beauregard; Jill K Edwards; Steven A Shea; David P White
Genioglossal inspiratory activation: central respiratory vs mechanoreceptive influences.
Respiration physiology 2001;127(1):23-38.
2001: A Malhotra; Giora Pillar; Robert B Fogel; J Beauregard; J Edwards; David P White
Upper-airway collapsibility: measurements and sleep effects.
Chest 2001;120(1):156-61.
2001: Atul Malhotra; D R Schwartz; N Ayas; Michael L Stanchina; David P White
Treatment of oxygen-induced hypercapnia.
Lancet 2001;357(9259):884-5.
2001: Toshiki Akahoshi; David P White; Jill K Edwards; J Beauregard; Steven A Shea
Phasic mechanoreceptor stimuli can induce phasic activation of upper airway muscles in humans.
The Journal of physiology 2001;531(Pt 3):677-91.
2001: Robert B Fogel; A Malhotra; Giora Pillar; Stephen D Pittman; A Dunaif; David P White
Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 2001;86(3):1175-80.
2000: Giora Pillar; A Malhotra; Robert B Fogel; J Beauregard; Robert P Schnall; David P White
Airway mechanics and ventilation in response to resistive loading during sleep: influence of gender.
American journal of respiratory and critical care medicine 2000;162(5):1627-32.
2000: Giora Pillar; A Malhotra; Robert B Fogel; J Beauregard; DI Slamowitz; Steven A Shea; David P White
Upper airway muscle responsiveness to rising PCO(2) during NREM sleep.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;89(4):1275-82.
2000: A Malhotra; Giora Pillar; Robert B Fogel; J Beauregard; Jill K Edwards; DI Slamowitz; Steven A Shea; David P White
Genioglossal but not palatal muscle activity relates closely to pharyngeal pressure.
American journal of respiratory and critical care medicine 2000;162(3 Pt 1):1058-62.
2000: Steven A Shea; Toshiki Akahoshi; Jill K Edwards; David P White
Influence of chemoreceptor stimuli on genioglossal response to negative pressure in humans.
American journal of respiratory and critical care medicine 2000;162(2 Pt 1):559-65.
2000: DI Slamowitz; Jill K Edwards; T Chajek-Shaul; David P White
The influence of a transmucosal cholinergic agonist on pharyngeal muscle activity.
Sleep 2000;23(4):543-50.
2000: A Malhotra; Robert B Fogel; Jill K Edwards; Steven A Shea; David P White
Local mechanisms drive genioglossus activation in obstructive sleep apnea.
American journal of respiratory and critical care medicine 2000;161(5):1746-9.
2000: Robert B Fogel; Atul Malhotra; Steven A Shea; Jill K Edwards; David P White
Reduced genioglossal activity with upper airway anesthesia in awake patients with OSA.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(4):1346-54.
2000: Robert B Fogel; David P White
Obstructive sleep apnea.
Advances in internal medicine 2000;45():351-89.
1999: Steven A Shea; Jill K Edwards; David P White
Effect of wake-sleep transitions and rapid eye movement sleep on pharyngeal muscle response to negative pressure in humans.
The Journal of physiology 1999;520 Pt 3():897-908.
1998: David P White; Jill K Edwards; Steven A Shea
Local reflex mechanisms: influence on basal genioglossal muscle activation in normal subjects.
Sleep 1998;21(7):719-28.
1996: David P White
Complex home monitoring.
Sleep 1996;19(10 Suppl):S248-50.