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Morris White

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Publications

TOP 3
Marianna Sadagurski; Morris F White
Integrating metabolism and longevity through insulin and IGF1 signaling.
K D Copps; Morris F White
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2.
Marianna Sadagurski; Josh Skorupski; Ronald A DePinho; Justin C Jones; Alexandra Kuznetsova; Rebecca L Leshan; Martin G Myers; Christa Patterson; Aldo Rozzo; Morris F White
IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.

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All Publications

2013: Marianna Sadagurski; Morris F White
Integrating metabolism and longevity through insulin and IGF1 signaling.
Endocrinology and metabolism clinics of North America 2013;42(1):127-48.
2012: K D Copps; Morris F White
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2.
Diabetologia 2012;55(10):2565-82.
2012: Marianna Sadagurski; Josh Skorupski; Ronald A DePinho; Justin C Jones; Alexandra Kuznetsova; Rebecca L Leshan; Martin G Myers; Christa Patterson; Aldo Rozzo; Morris F White
IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.
Cell metabolism 2012;15(5):703-12.
2012: Zhiyong Cheng; Morris F White
kNOXing on the door of selective insulin resistance.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(5):1063-5.
2012: Zhiyong Cheng; Morris F White
The AKTion in non-canonical insulin signaling.
Nature medicine 2012;18(3):351-3.
2011: Yingjiang Zhou; Justin Lee; Candace M Reno; Cheng Sun; Sang Won Park; Jason Chung; Jaemin Lee; Simon J Fisher; Morris F White; Sudha B Biddinger; Umut Ozcan
Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction.
Nature medicine 2011;17(3):356-65.
2011: Yun Chau Long; Zhiyong Cheng; Kyle D Copps; Morris F White
Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways.
Molecular and cellular biology 2011;31(3):430-41.
2010: Zhiyong Cheng; Yolanda Tseng; Morris F White
Insulin signaling meets mitochondria in metabolism.
Trends in endocrinology and metabolism: TEM 2010;21(10):589-98.
2010: M Sadagurski; L Norquay; J Farhang; K D'Aquino; K Copps; Morris F White
Human IL6 enhances leptin action in mice.
Diabetologia 2010;53(3):525-35.
2010: Li Liang; Wei Hui Guo; Diego R Esquiliano; Masato Asai; Susana Rodriguez; Jodel Giraud; Jake A Kushner; Morris F White; Mary Frances Lopez
Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis.
Endocrinology 2010;151(2):741-7.
2009: Zhiyong Cheng; Shaodong Guo; Kyle Copps; Xiaochen Dong; Ramya Kollipara; Joseph T Rodgers; Ronald A DePinho; Pere Puigserver; Morris F White
Foxo1 integrates insulin signaling with mitochondrial function in the liver.
Nature medicine 2009;15(11):1307-11.
2009: Lisa D Norquay; Katharine E D'Aquino; Lynn M Opare-Addo; Alexandra Kuznetsova; Michael Haas; Jeffrey A Bluestone; Morris F White
Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice.
Endocrinology 2009;150(10):4531-40.
2009: Shaodong Guo; Kyle D Copps; Xiaocheng Dong; Sunmin Park; Zhiyong Cheng; Alessandro Pocai; Luciano Rossetti; Mini Sajan; Robert V Farese; Morris F White
The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.
Molecular and cellular biology 2009;29(18):5070-83.
2009: Morris F White
Metformin and insulin meet in a most atypical way.
Cell metabolism 2009;9(6):485-7.
2009: Kyle D Copps; Morris F White
Breathing room: the (un)natural history of adipose microhypoxia and insulin resistance.
Diabetes 2009;58(1):26-7.
2008: Xiaocheng C Dong; Kyle D Copps; Shaodong Guo; Yedan Li; Ramya Kollipara; Ronald A DePinho; Morris F White
Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.
Cell metabolism 2008;8(1):65-76.
2008: Akiko Taguchi; Morris F White
Insulin-like signaling, nutrient homeostasis, and life span.
Annual review of physiology 2008;70():191-212.
2007: Jodel Giraud; Michael Haas; Edward P Feener; Kyle D Copps; Xiaocheng Dong; Sarah L Dunn; Morris F White
Phosphorylation of Irs1 at SER-522 inhibits insulin signaling.
Molecular endocrinology (Baltimore, Md.) 2007;21(9):2294-302.
2007: Akiko Taguchi; Lynn M Wartschow; Morris F White
Brain IRS2 signaling coordinates life span and nutrient homeostasis.
Science (New York, N.Y.) 2007;317(5836):369-72.
2006: Shaodong Guo; Sarah L Dunn; Morris F White
The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling.
Molecular endocrinology (Baltimore, Md.) 2006;20(12):3389-99.
2006: Morris F White
Regulating insulin signaling and beta-cell function through IRS proteins.
Canadian journal of physiology and pharmacology 2006;84(7):725-37.
2006: Sunmin Park; Xiaocheng Dong; Tracy L Fisher; Sarah Dunn; A Kadir Omer; Gordon Weir; Morris F White
Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function.
The Journal of biological chemistry 2006;281(2):1159-68.
2006: Xiaocheng Dong; Sunmin Park; Xueying Lin; Kyle Copps; Xianjin Yi; Morris F White
Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth.
The Journal of clinical investigation 2006;116(1):101-14.
2005: Katsutaro Morino; Kitt Falk Petersen; Sylvie Dufour; Douglas Befroy; Jared C Frattini; Nadine Shatzkes; Susanne Neschen; Morris F White; Stefan Bilz; Saki Sono; Marc Pypaert; Gerald I Shulman
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.
The Journal of clinical investigation 2005;115(12):3587-93.
2005: Jake A Kushner; Laura Simpson; Lynn M Wartschow; Shaodong Guo; Matthew M Rankin; Ramon Parsons; Morris F White
Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis.
The Journal of biological chemistry 2005;280(47):39388-93.
2005: Anita M Hennige; Umut Ozcan; Terumasa Okada; Ulupi S Jhala; Markus Schubert; Morris F White; Rohit N Kulkarni
Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells.
American journal of physiology. Endocrinology and metabolism 2005;289(2):E337-46.
2005: Jake A Kushner; Maria A Ciemerych; Ewa Sicinska; Lynn M Wartschow; Monica Teta; Simon Y Long; Piotr Sicinski; Morris F White
Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth.
Molecular and cellular biology 2005;25(9):3752-62.
2005: Xianjin Yi; Markus Schubert; Neal S Peachey; Kiyoshi Suzuma; Deborah J Burks; Jake A Kushner; Izumi Suzuma; Christopher Cahill; Carrie L Flint; Matthew A Dow; Rebecca Leshan; George L King; Morris F White
Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(5):1240-8.
2004: Tracey L Fisher; Morris F White
Signaling pathways: the benefits of good communication.
Current biology : CB 2004;14(23):R1005-7.
2004: Angela M Valverde; Isabel Fabregat; Deborah J Burks; Morris F White; Manuel Benito
IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes.
Hepatology (Baltimore, Md.) 2004;40(6):1285-94.
2004: Cunming Duan; Hongyan Yang; Morris F White; Liangyou Rui
Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance.
Molecular and cellular biology 2004;24(17):7435-43.
2004: Nobuharu Fujii; Marni D Boppart; Scott D Dufresne; Patricia F Crowley; Alison C Jozsi; Kei Sakamoto; Haiyan Yu; william aschenbach; Shokei Kim; Hitoshi Miyazaki; Liangyou Rui; Morris F White; Michael F Hirshman; Laurie J Goodyear
Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity.
American journal of physiology. Cell physiology 2004;287(1):C200-8.
2004: Jodel Giraud; Rebecca Leshan; Yong-Hee Lee; Morris F White
Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling.
The Journal of biological chemistry 2004;279(5):3447-54.
2004: Jake A Kushner; Fawaz G Haj; Lori D Klaman; Matthew A Dow; Barbara B Kahn; Benjamin G Neel; Morris F White
Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice.
Diabetes 2004;53(1):61-6.
2003: Morris F White
Insulin signaling in health and disease.
Science (New York, N.Y.) 2003;302(5651):1710-1.
2003: Anita M Hennige; Deborah J Burks; Umut Ozcan; Rohit N Kulkarni; Jing Ye; Sunmin Park; Markus Schubert; Tracey L Fisher; Matthew A Dow; Rebecca Leshan; Mark Zakaria; Mahmud Mossa-Basha; Morris F White
Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes.
The Journal of clinical investigation 2003;112(10):1521-32.
2003: Angela M Valverde; Deborah J Burks; Isabel Fabregat; Tracey L Fisher; José Carretero; Morris F White; Manuel Benito
Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
Diabetes 2003;52(9):2239-48.
2003: Markus Schubert; Derek Brazil; Deborah J Burks; Jake A Kushner; Jing Ye; Carrie L Flint; Janet Farhang-Fallah; Pieter Dikkes; Xavier M Warot; Carlos Rio; Gabriel Corfas; Morris F White
Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(18):7084-92.
2003: Yong Hee Lee; Jodel Giraud; Roger J Davis; Morris F White
c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade.
The Journal of biological chemistry 2003;278(5):2896-902.
2002: Chunli Yu; Yan Chen; Gary W Cline; Dongyan Zhang; Haihong Zong; Yanlin Wang; Raynald Bergeron; Jason K Kim; Samuel W Cushman; Gregory J Cooney; Bronwyn Atcheson; Morris F White; Edward W Kraegen; Gerald I Shulman
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle.
The Journal of biological chemistry 2002;277(52):50230-6.
2002: Qing Chang; Yu Li; Morris F White; Jonathan A Fletcher; Sheng Xiao
Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications.
Cancer research 2002;62(21):6035-8.
2002: Liangyou Rui; Minsheng Yuan; Daniel Frantz; Steven E Shoelson; Morris F White
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2.
The Journal of biological chemistry 2002;277(44):42394-8.
2002: Morris F White
IRS proteins and the common path to diabetes.
American journal of physiology. Endocrinology and metabolism 2002;283(3):E413-22.
2002: Andrea L Wurster; Vikki L Rodgers; Morris F White; Thomas L Rothstein; Michael J Grusby
Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL.
The Journal of biological chemistry 2002;277(30):27169-75.
2002: Jake A Kushner; Jing Ye; Markus Schubert; Deborah J Burks; Matthew A Dow; Carrie L Flint; Sanjoy Dutta; Christopher V E Wright; Marc Montminy; Morris F White
Pdx1 restores beta cell function in Irs2 knockout mice.
The Journal of clinical investigation 2002;109(9):1193-201.
2002: Kirsten F Howlett; Kei Sakamoto; Michael F Hirshman; william aschenbach; Matthew Dow; Morris F White; Laurie J Goodyear
Insulin signaling after exercise in insulin receptor substrate-2-deficient mice.
Diabetes 2002;51(2):479-83.
2002: Vincent Aguirre; Eric D Werner; Jodel Giraud; Yong Hee Lee; Steven E Shoelson; Morris F White
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action.
The Journal of biological chemistry 2002;277(2):1531-7.
2002: Andrea L Wurster; Dominic J Withers; Tohru Uchida; Morris F White; Michael J Grusby
Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis.
Molecular and cellular biology 2002;22(1):117-26.
2001: Liangyou Rui; Tracey L Fisher; J Thomas; Morris F White
Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.
The Journal of biological chemistry 2001;276(43):40362-7.
2001: Deborah J Burks; Morris F White
IRS proteins and beta-cell function.
Diabetes 2001;50 Suppl 1():S140-5.
2001: Liangyou Rui; Vincent Aguirre; J K Kim; Gerald I Shulman; A Lee; Anne Corbould; Andrea Dunaif; Morris F White
Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways.
The Journal of clinical investigation 2001;107(2):181-9.
2000: Stephen Previs; DJ Withers; Jian Ming Ren; Morris F White; Gerald I Shulman
Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.
The Journal of biological chemistry 2000;275(50):38990-4.
2000: Deborah J Burks; Jaime Font de Mora; Markus Schubert; DJ Withers; Martin G Myers Jr; HH Towery; S L Altamuro; Carrie L Flint; Morris F White
IRS-2 pathways integrate female reproduction and energy homeostasis.
Nature 2000;407(6802):377-82.
2000: Mathias Fasshauer; Johannes Klein; Kohjiro Ueki; Kristina M Kriauciunas; M Benito; Morris F White; C Ronald Kahn
Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes.
The Journal of biological chemistry 2000;275(33):25494-501.
2000: Vincent Aguirre; T Uchida; Lynne Yenush; R Davis; Morris F White
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307).
The Journal of biological chemistry 2000;275(12):9047-54.
2000: Y Kido; D J Burks; DJ Withers; J C Bruning; C R Kahn; Morris F White; D Accili
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.
The Journal of clinical investigation 2000;105(2):199-205.
2000: T Uchida; Martin G Myers Jr; Morris F White
IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis.
Molecular and cellular biology 2000;20(1):126-38.
1999: Katrine Almind; S K Frederiksen; Dolores Bernal; Torben Hansen; Louise Ambye; Søren A Urhammer; C T Ekstrøm; Lars Berglund; R Reneland; H Lithell; Morris F White; Emmanuel Van Obberghen; Oluf Pedersen
Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity.
Diabetologia 1999;42(10):1244-9.
1999: DJ Withers; Deborah J Burks; HH Towery; S L Altamuro; Carrie L Flint; Morris F White
Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.
Nature genetics 1999;23(1):32-40.
1999: Zhen Y Jiang; Y W Lin; A Clemont; Edward P Feener; K D Hein; M Igarashi; T Yamauchi; Morris F White; George L King
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats.
The Journal of clinical investigation 1999;104(4):447-57.
1999: Y Higaki; J F Wojtaszewski; Michael F Hirshman; DJ Withers; HH Towery; Morris F White; Laurie J Goodyear
Insulin receptor substrate-2 is not necessary for insulin- and exercise-stimulated glucose transport in skeletal muscle.
The Journal of biological chemistry 1999;274(30):20791-5.
1999: M E Griffin; Melissa Marcucci; Gary W Cline; K Bell; N Barucci; D Lee; L J Goodyear; Edward W Kraegen; Morris F White; Gerald I Shulman
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
Diabetes 1999;48(6):1270-4.
1999: A Bektas; James H Warram; Morris F White; Andrzej S Krolewski; Alessandro Doria
Exclusion of insulin receptor substrate 2 (IRS-2) as a major locus for early-onset autosomal dominant type 2 diabetes.
Diabetes 1999;48(3):640-2.
1998: Deborah J Burks; J Wang; HH Towery; O Ishibashi; D Lowe; Heimo Riedel; Morris F White
IRS pleckstrin homology domains bind to acidic motifs in proteins.
The Journal of biological chemistry 1998;273(47):31061-7.
1998: Lynne Yenush; C Zanella; T Uchida; Dolores Bernal; Morris F White
The pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by insulin.
Molecular and cellular biology 1998;18(11):6784-94.
1998: Martin G Myers Jr; R Mendez; P Shi; J H Pierce; R Rhoads; Morris F White
The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling.
The Journal of biological chemistry 1998;273(41):26908-14.
1998: Dolores Bernal; Katrine Almind; Lynne Yenush; M Ayoub; Y Zhang; L Rosshani; C Larsson; Oluf Pedersen; Morris F White
Insulin receptor substrate-2 amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians.
Diabetes 1998;47(6):976-9.
1998: Morris F White
The IRS-signalling system: a network of docking proteins that mediate insulin action.
Molecular and cellular biochemistry 1998;182(1-2):3-11.
1998: DJ Withers; J S Gutierrez; HH Towery; Deborah J Burks; Jian Ming Ren; Stephen Previs; Y Zhang; Dolores Bernal; S Pons; Gerald I Shulman; Susan Bonner-Weir; Morris F White
Disruption of IRS-2 causes type 2 diabetes in mice.
Nature 1998;391(6670):900-4.
1998: Morris F White
The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action.
Recent progress in hormone research 1998;53():119-38.
1998: Morris F White; Lynne Yenush
The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action.
Current topics in microbiology and immunology 1998;228():179-208.
1997: JL Joyal; Deborah J Burks; S Pons; William F Matter; chris vlahos; Morris F White; David B Sacks
Calmodulin activates phosphatidylinositol 3-kinase.
The Journal of biological chemistry 1997;272(45):28183-6.
1997: Deborah J Burks; S Pons; HH Towery; J Smith-Hall; Martin G Myers Jr; Lynne Yenush; Morris F White
Heterologous pleckstrin homology domains do not couple IRS-1 to the insulin receptor.
The Journal of biological chemistry 1997;272(44):27716-21.
1997: J Smith-Hall; S Pons; Mary-Elizabeth Patti; Deborah J Burks; Lynne Yenush; Xiao Jian Sun; C Ronald Kahn; Morris F White
The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells.
Biochemistry 1997;36(27):8304-10.
1997: Morris F White
The insulin signalling system and the IRS proteins.
Diabetologia 1997;40 Suppl 2():S2-17.
1997: Lynne Yenush; Morris F White
The IRS-signalling system during insulin and cytokine action.
BioEssays : news and reviews in molecular, cellular and developmental biology 1997;19(6):491-500.
1997: Xiao Jian Sun; S Pons; L M Wang; Y Zhang; Lynne Yenush; Deborah J Burks; Martin G Myers Jr; E Glasheen; N G Copeland; N A Jenkins; J H Pierce; Morris F White
The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action.
Molecular endocrinology (Baltimore, Md.) 1997;11(2):251-62.
1996: Hidayatullah Munshi; Deborah J Burks; JL Joyal; Morris F White; David B Sacks
Ca2+ regulates calmodulin binding to IQ motifs in IRS-1.
Biochemistry 1996;35(49):15883-9.
1996: Lício A Velloso; Franco Folli; Xiao Jian Sun; Morris F White; Mario J A Saad; C Ronald Kahn
Cross-talk between the insulin and angiotensin signaling systems.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12490-5.
1996: Lynne Yenush; K J Makati; J Smith-Hall; O Ishibashi; Martin G Myers Jr; Morris F White
The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1.
The Journal of biological chemistry 1996;271(39):24300-6.
1996: Martin G Myers Jr; Y Zhang; G A Aldaz; T Grammer; E M Glasheen; Lynne Yenush; L M Wang; Xiao Jian Sun; John Blenis; J H Pierce; Morris F White
YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites.
Molecular and cellular biology 1996;16(8):4147-55.
1996: Xiao Jian Sun; S Pons; T Asano; Martin G Myers Jr; E Glasheen; Morris F White
The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation.
The Journal of biological chemistry 1996;271(18):10583-7.
1996: Lynne Yenush; R Fernandez; Martin G Myers Jr; T C Grammer; Xiao Jian Sun; John Blenis; J H Pierce; J Schlessinger; Morris F White
The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis.
Molecular and cellular biology 1996;16(5):2509-17.
1996: Shahab Uddin; A Yetter; S Katzav; C Hofmann; Morris F White; Leonidas C Platanias
Insulin-like growth factor-1 induces rapid tyrosine phosphorylation of the vav proto-oncogene product.
Experimental hematology 1996;24(5):622-7.
1996: Leonidas C Platanias; Shahab Uddin; A Yetter; Xiao Jian Sun; Morris F White
The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2.
The Journal of biological chemistry 1996;271(1):278-82.
1996: Martin G Myers Jr; Morris F White
Insulin signal transduction and the IRS proteins.
Annual review of pharmacology and toxicology 1996;36():615-58.
1995: Ling Mei Wang; P Michieli; W R Lie; F Liu; C C Lee; A Minty; Xiao Jian Sun; A Levine; Morris F White; JH Pierce
The insulin receptor substrate-1-related 4PS substrate but not the interleukin-2R gamma chain is involved in interleukin-13-mediated signal transduction.
Blood 1995;86(11):4218-27.
1995: G Wolf; T Trüb; EA Ottinger; L Groninga; A Lynch; Morris F White; M Miyazaki; Joonsoo Lee; Steven E Shoelson
PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities.
The Journal of biological chemistry 1995;270(46):27407-10.
1995: Mary-Elizabeth Patti; Xiao Jian Sun; J C Bruening; E Araki; M A Lipes; Morris F White; C Ronald Kahn
4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice.
The Journal of biological chemistry 1995;270(42):24670-3.
1995: Xiao Jian Sun; L M Wang; Y Zhang; Lynne Yenush; Martin G Myers Jr; E Glasheen; William Stratton Lane; J H Pierce; Morris F White
Role of IRS-2 in insulin and cytokine signalling.
Nature 1995;377(6545):173-7.
1995: Martin G Myers Jr; Bentley Cheatham; T L Fisher; B R Jachna; C Ronald Kahn; Jonathan M Backer; Morris F White
Common and distinct elements in insulin and PDGF signaling.
Annals of the New York Academy of Sciences 1995;766():369-87.
1995: S Pons; T Asano; E Glasheen; M Miralpeix; Y Zhang; T L Fisher; Martin G Myers Jr; Xiao Jian Sun; Morris F White
The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase.
Molecular and cellular biology 1995;15(8):4453-65.
1995: Shahab Uddin; Lynne Yenush; Xiao Jian Sun; M E Sweet; Morris F White; Leonidas C Platanias
Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase.
The Journal of biological chemistry 1995;270(27):15938-41.
1995: Martin G Myers Jr; T C Grammer; J Brooks; E M Glasheen; L M Wang; Xiao Jian Sun; John Blenis; J H Pierce; Morris F White
The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling.
The Journal of biological chemistry 1995;270(20):11715-8.
1995: Shahab Uddin; S Katzav; Morris F White; Leonidas C Platanias
Insulin-dependent tyrosine phosphorylation of the vav protooncogene product in cells of hematopoietic origin.
The Journal of biological chemistry 1995;270(13):7712-6.
1994: Martin G Myers Jr; T C Grammer; L M Wang; Xiao Jian Sun; J H Pierce; John Blenis; Morris F White
Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.
The Journal of biological chemistry 1994;269(46):28783-9.
1994: L M Chuang; S F Hausdorff; Martin G Myers Jr; Morris F White; Morris J Birnbaum; C Ronald Kahn
Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes.
The Journal of biological chemistry 1994;269(44):27645-9.
1994: Edward P Feener; T Shiba; K Q Hu; P A Wilden; Morris F White; George L King
Characterization of phorbol ester-stimulated serine phosphorylation of the human insulin receptor.
The Biochemical journal 1994;303 ( Pt 1)():43-50.
1994: Martin G Myers Jr; Xiao Jian Sun; Morris F White
The IRS-1 signaling system.
Trends in biochemical sciences 1994;19(7):289-93.
1994: Martin G Myers Jr; L M Wang; Xiao Jian Sun; Y Zhang; Lynne Yenush; J Schlessinger; J H Pierce; Morris F White
Role of IRS-1-GRB-2 complexes in insulin signaling.
Molecular and cellular biology 1994;14(6):3577-87.
1994: Morris F White
The IRS-1 signaling system.
Current opinion in genetics & development 1994;4(1):47-54.
1994: Lynne Yenush; Vikas Kundra; Morris F White; Bruce R Zetter
Functional domains of the insulin receptor responsible for chemotactic signaling.
The Journal of biological chemistry 1994;269(1):100-4.
1994: Morris F White; C Ronald Kahn
The insulin signaling system.
The Journal of biological chemistry 1994;269(1):1-4.
1993: Xiao Jian Sun; D L Crimmins; Martin G Myers Jr; M Miralpeix; Morris F White
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.
Molecular and cellular biology 1993;13(12):7418-28.
1993: L M Chuang; Martin G Myers Jr; Jonathan M Backer; Steven E Shoelson; Morris F White; M J Birnbaum; C Ronald Kahn
Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase.
Molecular and cellular biology 1993;13(11):6653-60.
1993: Milenko J Tanasijevic; Martin G Myers Jr; R S Thoma; D L Crimmins; Morris F White; David B Sacks
Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II.
The Journal of biological chemistry 1993;268(24):18157-66.
1993: E Araki; Xiao Jian Sun; B L Haag; L M Chuang; Y Zhang; T L Yang-Feng; Morris F White; C Ronald Kahn
Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization.
Diabetes 1993;42(7):1041-54.
1993: L M Chuang; Martin G Myers Jr; G A Seidner; Morris J Birnbaum; Morris F White; C Ronald Kahn
Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5172-5.
1993: Edward P Feener; Jonathan M Backer; George L King; P A Wilden; Xiao Jian Sun; C Ronald Kahn; Morris F White
Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor.
The Journal of biological chemistry 1993;268(15):11256-64.
1993: Martin G Myers Jr; Morris F White
The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains.
Diabetes 1993;42(5):643-50.
1993: Ling Mei Wang; Achsah D Keegan; Weiqun Li; G E Lienhard; S Pacini; J Silvio Gutkind; Martin G Myers Jr; Xiao Jian Sun; Morris F White; Stuart A Aaronson
Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4032-6.
1993: Jonathan M Backer; Martin G Myers Jr; Xiao Jian Sun; D J Chin; Steven E Shoelson; M Miralpeix; Morris F White
Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells.
The Journal of biological chemistry 1993;268(11):8204-12.
1993: Martin G Myers Jr; Xiao Jian Sun; Bentley Cheatham; B R Jachna; E M Glasheen; Jonathan M Backer; Morris F White
IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase.
Endocrinology 1993;132(4):1421-30.
1993: C Ronald Kahn; Morris F White; Steven E Shoelson; Jonathan M Backer; E Araki; Bentley Cheatham; Péter Csermely; Franco Folli; B J Goldstein; P Huertas
The insulin receptor and its substrate: molecular determinants of early events in insulin action.
Recent progress in hormone research 1993;48():291-339.
1992: Xiao Jian Sun; M Miralpeix; Martin G Myers Jr; E M Glasheen; Jonathan M Backer; C Ronald Kahn; Morris F White
Expression and function of IRS-1 in insulin signal transmission.
The Journal of biological chemistry 1992;267(31):22662-72.
1992: Martin G Myers Jr; Jonathan M Backer; Xiao Jian Sun; Steven E Shoelson; Patrick J Hu; J Schlessinger; M Yoakim; Brian Schaffhausen; Morris F White
IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10350-4.
1992: Mario J A Saad; E Araki; M Miralpeix; P L Rothenberg; Morris F White; C Ronald Kahn
Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.
The Journal of clinical investigation 1992;90(5):1839-49.
1992: M Miralpeix; Xiao Jian Sun; Jonathan M Backer; Martin G Myers Jr; E Araki; Morris F White
Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in Fao hepatoma cells.
Biochemistry 1992;31(37):9031-9.
1992: P A Wilden; C Ronald Kahn; K Siddle; Morris F White
Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function.
The Journal of biological chemistry 1992;267(23):16660-8.
1992: Jonathan M Backer; Steven E Shoelson; M A Weiss; Q X Hua; R B Cheatham; E Haring; D C Cahill; Morris F White
The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals.
The Journal of cell biology 1992;118(4):831-9.
1992: P A Wilden; K Siddle; E Haring; Jonathan M Backer; Morris F White; C Ronald Kahn
The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies.
The Journal of biological chemistry 1992;267(19):13719-27.
1992: Steven E Shoelson; S Chatterjee; M Chaudhuri; Morris F White
YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2027-31.
1992: Jonathan M Backer; G G Schroeder; C Ronald Kahn; Martin G Myers Jr; P A Wilden; D A Cahill; Morris F White
Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.
The Journal of biological chemistry 1992;267(2):1367-74.
1991: Jonathan M Backer; Steven E Shoelson; E Haring; Morris F White
Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region.
The Journal of cell biology 1991;115(6):1535-45.
1991: Xiao Jian Sun; P Rothenberg; C Ronald Kahn; Jonathan M Backer; E Araki; P A Wilden; D A Cahill; B J Goldstein; Morris F White
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein.
Nature 1991;352(6330):73-7.
1991: Jonathan M Backer; G G Schroeder; D A Cahill; A Ullrich; K Siddle; Morris F White
Cytoplasmic juxtamembrane region of the insulin receptor: a critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells.
Biochemistry 1991;30(26):6366-72.
1991: Martin G Myers Jr; Jonathan M Backer; K Siddle; Morris F White
The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus.
The Journal of biological chemistry 1991;266(16):10616-23.
1991: O Segatto; Fulvio Lonardo; D Wexler; F Fazioli; JH Pierce; Donald Bottaro; Morris F White; Pier Paolo Di Fiore
The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction.
Molecular and cellular biology 1991;11(6):3191-202.
1991: R Kapeller; K S Chen; M Yoakim; Brian Schaffhausen; Jonathan M Backer; Morris F White; Lewis C Cantley; N B Ruderman
Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin.
Molecular endocrinology (Baltimore, Md.) 1991;5(6):769-77.
1991: Morris F White
Structure and function of tyrosine kinase receptors.
Journal of bioenergetics and biomembranes 1991;23(1):63-82.
1991: M Okamoto; A Karasik; Morris F White; C Ronald Kahn
Coordinate phosphorylation of insulin-receptor kinase and its 175,000-Mr endogenous substrate in rat hepatocytes.
Diabetes 1991;40(1):66-72.
1990: M Okamoto; A Karasik; Morris F White; C Ronald Kahn
Epidermal growth factor stimulated phosphorylation of a 120-kilodalton endogenous substrate protein in rat hepatocytes.
Biochemistry 1990;29(40):9489-94.
1990: Jonathan M Backer; C Ronald Kahn; D A Cahill; A Ullrich; Morris F White
Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.
The Journal of biological chemistry 1990;265(27):16450-4.
1990: Jonathan M Backer; C Ronald Kahn; Morris F White
The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells.
The Journal of biological chemistry 1990;265(25):14828-35.
1990: A Karasik; P L Rothenberg; K Yamada; Morris F White; C Ronald Kahn
Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats.
The Journal of biological chemistry 1990;265(18):10226-31.
1990: P A Wilden; Jonathan M Backer; C Ronald Kahn; D A Cahill; G J Schroeder; Morris F White
The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(9):3358-62.
1990: Y T Kruszynska; P A Halban; C Ronald Kahn; Morris F White
Activation of liver and muscle insulin receptor tyrosine kinase activity during in vivo insulin administration in rats.
Diabetologia 1990;33(2):77-83.
1990: N B Ruderman; R Kapeller; Morris F White; Lewis C Cantley
Activation of phosphatidylinositol 3-kinase by insulin.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(4):1411-5.
1989: R Perlman; Donald Bottaro; Morris F White; C Ronald Kahn
Conformational changes in the alpha- and beta-subunits of the insulin receptor identified by anti-peptide antibodies.
The Journal of biological chemistry 1989;264(15):8946-50.
1989: Steven E Shoelson; Morris F White; C Ronald Kahn
Nonphosphorylatable substrate analogs selectively block autophosphorylation and activation of the insulin receptor, epidermal growth factor receptor, and pp60v-src kinases.
The Journal of biological chemistry 1989;264(14):7831-6.
1989: Jonathan M Backer; C Ronald Kahn; Morris F White
Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(9):3209-13.
1989: Morris F White; C Ronald Kahn
Cascade of autophosphorylation in the beta-subunit of the insulin receptor.
Journal of cellular biochemistry 1989;39(4):429-41.
1989: Jonathan M Backer; C Ronald Kahn; Morris F White
Tyrosine phosphorylation of the insulin receptor during insulin-stimulated internalization in rat hepatoma cells.
The Journal of biological chemistry 1989;264(3):1694-701.
1988: C Ronald Kahn; Morris F White
The insulin receptor and the molecular mechanism of insulin action.
The Journal of clinical investigation 1988;82(4):1151-6.
1988: Morris F White; J N Livingston; Jonathan M Backer; V Lauris; T J Dull; A Ullrich; C Ronald Kahn
Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity.
Cell 1988;54(5):641-9.
1988: Steven E Shoelson; Morris F White; C Ronald Kahn
Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control.
The Journal of biological chemistry 1988;263(10):4852-60.
1988: M Okamoto; C Ronald Kahn; R Maron; Morris F White
Decreased autophosphorylation of EGF receptor in insulin-deficient diabetic rats.
The American journal of physiology 1988;254(4 Pt 1):E429-34.
1988: S Takayama; Morris F White; C Ronald Kahn
Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.
The Journal of biological chemistry 1988;263(7):3440-7.
1988: Morris F White; Steven E Shoelson; H Keutmann; C Ronald Kahn
A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.
The Journal of biological chemistry 1988;263(6):2969-80.