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Luke Whitesell

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Catherine A McLellan; Luke Whitesell; Oliver D King; Alex K Lancaster; Ralph Mazitschek; Susan Lindquist
Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity.
Marc L. Mendillo; Sandro Santagata; Rulla M Tamimi; Luke Whitesell; George W Bell; Ernest Fraenkel; Rong Hu; Tan Ince; Martina Koeva; Susan Lindquist
HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.
E M Kithsiri Wijeratne; A Elizabeth Arnold; Bharat P Bashyal; G M Kamal B Gunaherath; Malkanthi K Gunatilaka; Manping X Liu; Danilo D Rocha; Jana M U'Ren; Luke Whitesell; Leslie Gunatilaka
Geopyxins A-E, ent-kaurane diterpenoids from endolichenic fungal strains Geopyxis aff. majalis and Geopyxis sp. AZ0066: structure-activity relationships of geopyxins and their analogues.

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All Publications

2012: Catherine A McLellan; Luke Whitesell; Oliver D King; Alex K Lancaster; Ralph Mazitschek; Susan Lindquist
Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity.
ACS chemical biology 2012;7(9):1520-8.
2012: Marc L. Mendillo; Sandro Santagata; Rulla M Tamimi; Luke Whitesell; George W Bell; Ernest Fraenkel; Rong Hu; Tan Ince; Martina Koeva; Susan Lindquist
HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.
Cell 2012;150(3):549-62.
2012: E M Kithsiri Wijeratne; A Elizabeth Arnold; Bharat P Bashyal; G M Kamal B Gunaherath; Malkanthi K Gunatilaka; Manping X Liu; Danilo D Rocha; Jana M U'Ren; Luke Whitesell; Leslie Gunatilaka
Geopyxins A-E, ent-kaurane diterpenoids from endolichenic fungal strains Geopyxis aff. majalis and Geopyxis sp. AZ0066: structure-activity relationships of geopyxins and their analogues.
Journal of natural products 2012;75(3):361-9.
2012: Luke Whitesell; Nancy U Lin
HSP90 as a platform for the assembly of more effective cancer chemotherapy.
Biochimica et biophysica acta 2012;1823(3):756-66.
2009: Luke Whitesell; Susan Lindquist
Inhibiting the transcription factor HSF1 as an anticancer strategy.
Expert opinion on therapeutic targets 2009;13(4):469-78.
2009: Ya-ming Xu; Marilyn T Marron; Emily Seddon; Steven P McLaughlin; Dennis T Ray; Luke Whitesell; Leslie Gunatilaka
2,3-Dihydrowithaferin A-3beta-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera.
Bioorganic & medicinal chemistry 2009;17(6):2210-4.
2009: Leah E Cowen; Sheena D Singh; Julia R Köhler; Cathy Collins; Aimee K Zaas; Wiley A Schell; Hamza Aziz; Eleftherios Mylonakis; John R Perfect; Luke Whitesell; Susan Lindquist
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2818-23.
2008: Robert H J Hargreaves; Cynthia L David; Luke Whitesell; Daniel V Labarbera; Akmal Jamil; Jean-Charles Chapuis; Edward B Skibo
Discovery of quinolinediones exhibiting a heat shock response and angiogenesis inhibition.
Journal of medicinal chemistry 2008;51(8):2492-501.
2007: Chengkai Dai; Luke Whitesell; Arlin Rogers; Susan Lindquist
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.
Cell 2007;130(6):1005-18.
2007: Catherine A McLellan; Thomas J Turbyville; E M Kithsiri Wijeratne; Arthur Kerschen; Elizabeth Vierling; Christine Queitsch; Luke Whitesell; Leslie Gunatilaka
A rhizosphere fungus enhances Arabidopsis thermotolerance through production of an HSP90 inhibitor.
Plant physiology 2007;145(1):174-82.
2007: Brenda J Weigel; Susan M Blaney; Joel M Reid; Stephanie L Safgren; Rochelle Bagatell; John H Kersey; Joseph P Neglia; S Percy Ivy; Ashish Ingle; Luke Whitesell; Richard J Gilbertson; Mark Krailo; Matthew Ames; Peter Charles Adamson
A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children's Oncology Group study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(6):1789-93.
2007: Rochelle Bagatell; Lia Gore; Merrill J Egorin; Richard Ho; Glenn Heller; Nichole Boucher; Eleanor G Zuhowski; James A Whitlock; Stephen P Hunger; Aru Narendran; Howard M Katzenstein; Robert J Arceci; Jessica Boklan; Cynthia E Herzog; Luke Whitesell; S Percy Ivy; Tanya M Trippett
Phase I pharmacokinetic and pharmacodynamic study of 17-N-allylamino-17-demethoxygeldanamycin in pediatric patients with recurrent or refractory solid tumors: a pediatric oncology experimental therapeutics investigators consortium study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(6):1783-8.
2006: E M Kithsiri Wijeratne; Thomas J Turbyville; Anne Fritz; Luke Whitesell; Leslie Gunatilaka
A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity.
Bioorganic & medicinal chemistry 2006;14(23):7917-23.
2006: Sara B. Cullinan Gladden; Luke Whitesell
Heat shock protein 90: a unique chemotherapeutic target.
Seminars in oncology 2006;33(4):457-65.
2006: Thomas J Turbyville; E M Kithsiri Wijeratne; Manping X Liu; Anna M Burns; Christopher J Seliga; Libia A Luevano; Cynthia L David; Stanley H Faeth; Luke Whitesell; Leslie Gunatilaka
Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
Journal of natural products 2006;69(2):178-84.
2006: Ryan R Falsey; Marilyn T Marron; G M Kamal B Gunaherath; Nikhil Shirahatti; Daruka Mahadevan; Leslie Gunatilaka; Luke Whitesell
Actin microfilament aggregation induced by withaferin A is mediated by annexin II.
Nature chemical biology 2006;2(1):33-8.
2005: Thomas J Turbyville; E M Kithsiri Wijeratne; Luke Whitesell; Leslie Gunatilaka
The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways.
Molecular cancer therapeutics 2005;4(10):1569-76.
2005: Luke Whitesell; Susan L Lindquist
HSP90 and the chaperoning of cancer.
Nature reviews. Cancer 2005;5(10):761-72.
2005: Brandon D Jeffy; Jennifer K Hockings; Michael Q Kemp; Sherif S Morgan; Jill A Hager; Jason Beliakoff; Luke Whitesell; George Bowden; Donato F Romagnolo
An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription.
Neoplasia (New York, N.Y.) 2005;7(9):873-82.
2005: Chengkai Dai; Luke Whitesell
HSP90: a rising star on the horizon of anticancer targets.
Future oncology (London, England) 2005;1(4):529-40.
2005: Eileen Devaney; Kerry O'neill; William Harnett; Luke Whitesell; Jane H Kinnaird
Hsp90 is essential in the filarial nematode Brugia pahangi.
International journal for parasitology 2005;35(6):627-36.
2005: Rochelle Bagatell; Jason Beliakoff; Cynthia L David; Marilyn T Marron; Luke Whitesell
Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin.
International journal of cancer. Journal international du cancer 2005;113(2):179-88.
2004: E M Kithsiri Wijeratne; Carlos A Carbonezi; Jacqueline A Takahashi; Christopher J Seliga; Thomas J Turbyville; Elizabeth E Pierson; Leland S Pierson; Hans D VanEtten; Luke Whitesell; Vanderlan da Silva Bolzani; Leslie Gunatilaka
Isolation, optimization of production and structure-activity relationship studies of monocillin I, the cytotoxic constituent of Paraphaeosphaeria quadriseptata.
The Journal of antibiotics 2004;57(8):541-6.
2004: Rochelle Bagatell; Luke Whitesell
Altered Hsp90 function in cancer: a unique therapeutic opportunity.
Molecular cancer therapeutics 2004;3(8):1021-30.
2004: Jason Beliakoff; Luke Whitesell
Hsp90: an emerging target for breast cancer therapy.
Anti-cancer drugs 2004;15(7):651-62.
2004: Linda C Meade-Tollin; E M Kithsiri Wijeratne; Deborah Cooper; Mischa Guild; Edlyn Jon; Anne Fritz; Guang-Xiong Zhou; Luke Whitesell; Jing-Yu Liang; Leslie Gunatilaka
Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES.
Journal of natural products 2004;67(1):2-4.
2003: E M Kithsiri Wijeratne; Thomas J Turbyville; Zhongge Zhang; Donna Bigelow; Leland S Pierson; Hans D VanEtten; Luke Whitesell; Louise M Canfield; Leslie Gunatilaka
Cytotoxic constituents of Aspergillus terreus from the rhizosphere of Opuntia versicolor of the Sonoran Desert.
Journal of natural products 2003;66(12):1567-73.
2003: Jason Beliakoff; Rochelle Bagatell; Gillian Paine-Murrieta; Charles W Taylor; Anne E Lykkesfeldt; Luke Whitesell
Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):4961-71.
2003: Luke Whitesell; Rochelle Bagatell; Ryan Falsey
The stress response: implications for the clinical development of hsp90 inhibitors.
Current cancer drug targets 2003;3(5):349-58.
2003: Robert Hargreaves; Cynthia L David; Luke Whitesell; Edward B Skibo
Design of quinolinedione-based geldanamycin analogues.
Bioorganic & medicinal chemistry letters 2003;13(18):3075-8.
2003: James J Kobie; Rita S Wu; Robert A Kurt; Sunming Lou; Miranda K Adelman; Luke Whitesell; Lalitha V Ramanathapuram; Carlos L Arteaga; Emmanuel T Akporiaye
Transforming growth factor beta inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines.
Cancer research 2003;63(8):1860-4.
2003: Gabriela Chiosis; Henri Huezo; Neal Rosen; Edward G Mimnaugh; Luke Whitesell; Len Neckers
17AAG: low target binding affinity and potent cell activity--finding an explanation.
Molecular cancer therapeutics 2003;2(2):123-9.
2003: Cynthia L David; Harold E Smith; Deborah A Raynes; Elizabeth J Pulcini; Luke Whitesell
Expression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegans.
Cell stress & chaperones 2003;8(1):93-104.
2002: Rochelle Bagatell; Elaine Morgan; Catherine Cosentino; Luke Whitesell
Two cases of pediatric neuroblastoma with tumor thrombus in the inferior vena cava.
Journal of pediatric hematology/oncology 2002;24(5):397-400.
2001: Rochelle Bagatell; O Khan; Gillian Paine-Murrieta; Charles W Taylor; S Akinaga; Luke Whitesell
Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):2076-84.
2001: Hanping Feng; Yi Zeng; Luke Whitesell; Emmanuel Katsanis
Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity.
Blood 2001;97(11):3505-12.
2001: L He; Hanping Feng; Amy Raymond; M Kreeger; Yi Zeng; Michael W Graner; Luke Whitesell; Emmanuel Katsanis
Dendritic-cell-peptide immunization provides immunoprotection against bcr-abl-positive leukemia in mice.
Cancer immunology, immunotherapy : CII 2001;50(1):31-40.
2001: Craig L Bennett; J Christie; Fred Ramsdell; Mary E Brunkow; PJ Ferguson; Luke Whitesell; TE Kelly; Frank T Saulsbury; Phillip F Chance; Hans D Ochs
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.
Nature genetics 2001;27(1):20-1.
2000: Rochelle Bagatell; Gillian Paine-Murrieta; Charles W Taylor; Elizabeth J Pulcini; S Akinaga; I J Benjamin; Luke Whitesell
Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(8):3312-8.
2000: Peter D Yorgin; Steven D Hartson; Abdul M Fellah; Bradley T Scroggins; Wei Huang; Emmanuel Katsanis; J M Couchman; Robert L Matts; Luke Whitesell
Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):2915-23.
2000: Michael W Graner; Amy Raymond; D Romney; L He; Luke Whitesell; Emmanuel Katsanis
Immunoprotective activities of multiple chaperone proteins isolated from murine B-cell leukemia/lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):909-15.
2000: Peter D Yorgin; D K Eklund; Amira Y Al-Uzri; Luke Whitesell; Andreas A Theodorou
Concurrent centrifugation plasmapheresis and continuous venovenous hemodiafiltration.
Pediatric nephrology (Berlin, Germany) 2000;14(1):18-21.
1999: Luke Whitesell; X Liu; Rochelle Bagatell
Inhibition of oncogene expression using vector-generated RNA antisense.
Methods (San Diego, Calif.) 1999;18(3):296-303.
1999: Zsolt Lele; Steven D Hartson; C Cristofre Martin; Luke Whitesell; Robert L Matts; Patrick H Krone
Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90.
Developmental biology 1999;210(1):56-70.
1999: Steven D Hartson; Vanitha Thulasiraman; Wei Huang; Luke Whitesell; Robert L Matts
Molybdate inhibits hsp90, induces structural changes in its C-terminal domain, and alters its interactions with substrates.
Biochemistry 1999;38(12):3837-49.
1998: D F Smith; Luke Whitesell; Emmanuel Katsanis
Molecular chaperones: biology and prospects for pharmacological intervention.
Pharmacological reviews 1998;50(4):493-514.
1998: X Liu; Thomas J Turbyville; Anne Fritz; Luke Whitesell
Inhibition of insulin-like growth factor I receptor expression in neuroblastoma cells induces the regression of established tumors in mice.
Cancer research 1998;58(23):5432-8.
1998: Marvin J Slepian; Stephen P Massia; B Dehdashti; Anne Fritz; Luke Whitesell
Beta3-integrins rather than beta1-integrins dominate integrin-matrix interactions involved in postinjury smooth muscle cell migration.
Circulation 1998;97(18):1818-27.
1998: Luke Whitesell; P D Sutphin; Elizabeth J Pulcini; Jesse D Martinez; P H Cook
The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent.
Molecular and cellular biology 1998;18(3):1517-24.
1997: Luke Whitesell; P Sutphin; Won G An; TW Schulte; Mikhail V Blagosklonny; Len Neckers
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.
Oncogene 1997;14(23):2809-16.
1996: Marvin J Slepian; Stephen P Massia; Luke Whitesell
Pre-conditioning of smooth muscle cells via induction of the heat shock response limits proliferation following mechanical injury.
Biochemical and biophysical research communications 1996;225(2):600-7.
1996: Luke Whitesell; P Cook
Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells.
Molecular endocrinology (Baltimore, Md.) 1996;10(6):705-12.
1996: C Chavany; Edward G Mimnaugh; P Miller; R Bitton; Phuongmai Nguyen; Jane Trepel; Luke Whitesell; R Schnur; J Moyer; Len Neckers
p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.
The Journal of biological chemistry 1996;271(9):4974-7.
1996: Yoshitatsu Sei; Luke Whitesell; Y Kustova; I A Paul; Herbert C Morse; Phil Skolnick; Anthony Basile
Altered brain fyn kinase in a murine acquired immunodeficiency syndrome.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(2):339-44.
1996: Leonard M Neckers; D Geselowitz; C Chavany; Luke Whitesell; Raymond C Bergan
Antisense efficacy : site-restricted in vivo and ex vivo models.
Methods in molecular medicine 1996;1():47-56.
1995: David F Smith; Luke Whitesell; S C Nair; S Chen; V Prapapanich; Ronald A Rimerman
Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent.
Molecular and cellular biology 1995;15(12):6804-12.
1995: Edward G Mimnaugh; P J Worland; Luke Whitesell; Leonard M Neckers
Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase.
The Journal of biological chemistry 1995;270(48):28654-9.
1994: Luke Whitesell; Edward G Mimnaugh; B De Costa; Charles E Myers; Leonard M Neckers
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(18):8324-8.
1994: Yung-Jue Bang; F Pirnia; W G Fang; W K Kang; Oliver Sartor; Luke Whitesell; M J Ha; Maria Tsokos; M D Sheahan; Phuongmai Nguyen; W T Niklinski; Charles E Myers; Jane Trepel
Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMP.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5330-4.
1993: Len Neckers; Luke Whitesell
Antisense technology: biological utility and practical considerations.
The American journal of physiology 1993;265(1 Pt 1):L1-12.
1993: Luke Whitesell; D Geselowitz; C Chavany; B Fahmy; Stuart Walbridge; J R Alger; Leonard M Neckers
Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: implications for therapeutic application within the central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4665-9.
1992: Len Neckers; Angelo Rosolen; B Fahmy; Luke Whitesell
Specific inhibition of oncogene expression in vitro and in vivo by antisense oligonucleotides.
Annals of the New York Academy of Sciences 1992;660():37-44.
1992: Leonard M Neckers; Angelo Rosolen; Luke Whitesell
Antisense inhibition of gene expression: a tool for studying the role of NMYC in the growth and differentiation of neuroectoderm-derived cells.
Journal of immunotherapy : official journal of the Society for Biological Therapy 1992;12(3):162-6.
1992: Luke Whitesell; S D Shifrin; G Schwab; Leonard M Neckers
Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition.
Cancer research 1992;52(7):1721-8.
1992: Angelo Rosolen; Oscar R Colamonici; Lawrence M Pfeffer; Luke Whitesell; R Nordan; Leonard M Neckers
Detection of functional interferon alpha receptors in human neuroendocrine tumor cell lines using a new monoclonal antibody.
European cytokine network 1992;3(2):81-8.
1992: Len Neckers; Luke Whitesell; Angelo Rosolen; D A Geselowitz
Antisense inhibition of oncogene expression.
Critical reviews in oncogenesis 1992;3(1-2):175-231.
1991: Luke Whitesell; Angelo Rosolen; Leonard M Neckers
Episome-generated N-myc antisense RNA restricts the differentiation potential of primitive neuroectodermal cell lines.
Molecular and cellular biology 1991;11(3):1360-71.
1991: Luke Whitesell; Angelo Rosolen; Leonard M Neckers
Antisense suppression of N-myc expression inhibits the transdifferentiation of neuroectoderm tumor cell lines.
Progress in clinical and biological research 1991;366():45-54.
1991: Angelo Rosolen; Luke Whitesell; Naohiko Ikegaki; R Kennett; Leonard M Neckers
Antisense inhibition of N-myc reduces cell growth but does not affect c-myc expression in the neuroepithelioma cell line CHP100.
Progress in clinical and biological research 1991;366():29-36.
1991: Luke Whitesell; Angelo Rosolen; Leonard M Neckers
In vivo modulation of N-myc expression by continuous perfusion with an antisense oligonucleotide.
Antisense research and development 1991;1(4):343-50.
1990: Angelo Rosolen; Luke Whitesell; Naohiko Ikegaki; R H Kennett; Leonard M Neckers
Antisense inhibition of single copy N-myc expression results in decreased cell growth without reduction of c-myc protein in a neuroepithelioma cell line.
Cancer research 1990;50(19):6316-22.