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Luke Whitesell

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Mice

Anatomy

Disorders

Neuroectodermal Tumors, Primitive, Peripheral

Physiology

Concepts & Ideas

Molecular Sequence Data

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Co-Publications
Name
11
Neckers, Leonard
10
Bagatell, Rochelle
9
Rosolen, Angelo
9
Gunatilaka, Leslie
7
Turbyville, Thomas
7
Wijeratne, Kithsiri
6
Neckers, Len
5
Katsanis, Emmanuel
5
David, Cynthia
4
Fritz, Anne
4
Beliakoff, Jason
4
Mimnaugh, Edward
3
Matts, Robert
3
Marron, Marilyn
3
Pulcini, Elizabeth

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Publications

TOP 3
Whitesell Luke; Lindquist Susan
Inhibiting the transcription factor HSF1 as an anticancer strategy.
Xu Ya-ming; Marron Marilyn T; Seddon Emily; McLaughlin Steven P; Ray Dennis T; Whitesell Luke; Gunatilaka A A Leslie
2,3-Dihydrowithaferin A-3beta-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera.
Cowen Leah E; Singh Sheena D; Köhler Julia R; Collins Cathy; Zaas Aimee K; Schell Wiley A; Aziz Hamza; Mylonakis Eleftherios; Perfect John R; Whitesell Luke; Lindquist Susan
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.

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All Publications

2009: Whitesell Luke; Lindquist Susan
Inhibiting the transcription factor HSF1 as an anticancer strategy.
Expert opinion on therapeutic targets 2009;13(4):469-78.
2009: Xu Ya-ming; Marron Marilyn T; Seddon Emily; McLaughlin Steven P; Ray Dennis T; Whitesell Luke; Gunatilaka A A Leslie
2,3-Dihydrowithaferin A-3beta-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera.
Bioorganic & medicinal chemistry 2009;17(6):2210-4.
2009: Cowen Leah E; Singh Sheena D; Köhler Julia R; Collins Cathy; Zaas Aimee K; Schell Wiley A; Aziz Hamza; Mylonakis Eleftherios; Perfect John R; Whitesell Luke; Lindquist Susan
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2818-23.
2008: Hargreaves Robert H J; David Cynthia L; Whitesell Luke J; Labarbera Daniel V; Jamil Akmal; Chapuis Jean C; Skibo Edward B
Discovery of quinolinediones exhibiting a heat shock response and angiogenesis inhibition.
Journal of medicinal chemistry 2008;51(8):2492-501.
2007: Dai Chengkai; Whitesell Luke; Rogers Arlin B; Lindquist Susan
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.
Cell 2007;130(6):1005-18.
2007: McLellan Catherine A; Turbyville Thomas J; Wijeratne E M Kithsiri; Kerschen Arthur; Vierling Elizabeth; Queitsch Christine; Whitesell Luke; Gunatilaka A A Leslie
A rhizosphere fungus enhances Arabidopsis thermotolerance through production of an HSP90 inhibitor.
Plant physiology 2007;145(1):174-82.
2007: Weigel Brenda J; Blaney Susan M; Reid Joel M; Safgren Stephanie L; Bagatell Rochelle; Kersey John; Neglia Joseph P; Ivy S Percy; Ingle Ashish M; Whitesell Luke; Gilbertson Richard J; Krailo Mark; Ames Matthew; Adamson Peter C
A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children's Oncology Group study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(6):1789-93.
2007: Bagatell Rochelle; Gore Lia; Egorin Merrill J; Ho Richard; Heller Glenn; Boucher Nichole; Zuhowski Eleanor G; Whitlock James A; Hunger Stephen P; Narendran Aru; Katzenstein Howard M; Arceci Robert J; Boklan Jessica; Herzog Cynthia E; Whitesell Luke; Ivy S Percy; Trippett Tanya M
Phase I pharmacokinetic and pharmacodynamic study of 17-N-allylamino-17-demethoxygeldanamycin in pediatric patients with recurrent or refractory solid tumors: a pediatric oncology experimental therapeutics investigators consortium study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(6):1783-8.
2006: Wijeratne E M Kithsiri; Turbyville Thomas J; Fritz Anne; Whitesell Luke; Gunatilaka A A Leslie
A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity.
Bioorganic & medicinal chemistry 2006;14(23):7917-23.
2006: Cullinan Sara B; Whitesell Luke
Heat shock protein 90: a unique chemotherapeutic target.
Seminars in oncology 2006;33(4):457-65.
2006: Turbyville Thomas J; Wijeratne E M Kithsiri; Liu Manping X; Burns Anna M; Seliga Christopher J; Luevano Libia A; David Cynthia L; Faeth Stanley H; Whitesell Luke; Gunatilaka A A Leslie
Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
Journal of natural products 2006;69(2):178-84.
2006: Falsey Ryan R; Marron Marilyn T; Gunaherath G M Kamal B; Shirahatti Nikhil; Mahadevan Daruka; Gunatilaka A A Leslie; Whitesell Luke
Actin microfilament aggregation induced by withaferin A is mediated by annexin II.
Nature chemical biology 2006;2(1):33-8.
2005: Turbyville Thomas J; Wijeratne E M Kithsiri; Whitesell Luke; Gunatilaka A A Leslie
The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways.
Molecular cancer therapeutics 2005;4(10):1569-76.
2005: Whitesell Luke; Lindquist Susan L
HSP90 and the chaperoning of cancer.
Nature reviews. Cancer 2005;5(10):761-72.
2005: Jeffy Brandon D; Hockings Jennifer K; Kemp Michael Q; Morgan Sherif S; Hager Jill A; Beliakoff Jason; Whitesell Luke J; Bowden G Timothy; Romagnolo Donato F
An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription.
Neoplasia (New York, N.Y.) 2005;7(9):873-82.
2005: Dai Chengkai; Whitesell Luke
HSP90: a rising star on the horizon of anticancer targets.
Future oncology (London, England) 2005;1(4):529-40.
2005: Devaney Eileen; O'neill Kerry; Harnett William; Whitesell Luke; Kinnaird Jane H
Hsp90 is essential in the filarial nematode Brugia pahangi.
International journal for parasitology 2005;35(6):627-36.
2005: Bagatell Rochelle; Beliakoff Jason; David Cynthia L; Marron Marilyn T; Whitesell Luke
Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin.
International journal of cancer. Journal international du cancer 2005;113(2):179-88.
2004: Wijeratne E M Kithsiri; Carbonezi Carlos A; Takahashi Jacqueline A; Seliga Christopher J; Turbyville Thomas J; Pierson Elizabeth E; Pierson Leland S; VanEtten Hans D; Whitesell Luke; Bolzani Vanderlan da S; Gunatilaka A A Leslie
Isolation, optimization of production and structure-activity relationship studies of monocillin I, the cytotoxic constituent of Paraphaeosphaeria quadriseptata.
The Journal of antibiotics 2004;57(8):541-6.
2004: Bagatell Rochelle; Whitesell Luke
Altered Hsp90 function in cancer: a unique therapeutic opportunity.
Molecular cancer therapeutics 2004;3(8):1021-30.
2004: Beliakoff Jason; Whitesell Luke
Hsp90: an emerging target for breast cancer therapy.
Anti-cancer drugs 2004;15(7):651-62.
2004: Meade-Tollin Linda C; Wijeratne E M Kithsiri; Cooper Deborah; Guild Mischa; Jon Edlyn; Fritz Anne; Zhou Guang-Xiong; Whitesell Luke; Liang Jing-Yu; Gunatilaka A A Leslie
Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES.
Journal of natural products 2004;67(1):2-4.
2003: Wijeratne E M Kithsiri; Turbyville Thomas J; Zhang Zhongge; Bigelow Donna; Pierson Leland S; VanEtten Hans D; Whitesell Luke; Canfield Louise M; Gunatilaka A A Leslie
Cytotoxic constituents of Aspergillus terreus from the rhizosphere of Opuntia versicolor of the Sonoran Desert.
Journal of natural products 2003;66(12):1567-73.
2003: Beliakoff Jason; Bagatell Rochelle; Paine-Murrieta Gillian; Taylor Charles W; Lykkesfeldt Anne E; Whitesell Luke
Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):4961-71.
2003: Whitesell Luke; Bagatell Rochelle; Falsey Ryan
The stress response: implications for the clinical development of hsp90 inhibitors.
Current cancer drug targets 2003;3(5):349-58.
2003: Hargreaves Robert; David Cynthia L; Whitesell Luke; Skibo Edward B
Design of quinolinedione-based geldanamycin analogues.
Bioorganic & medicinal chemistry letters 2003;13(18):3075-8.
2003: Kobie James J; Wu Rita S; Kurt Robert A; Lou Sunming; Adelman Miranda K; Whitesell Luke J; Ramanathapuram Lalitha V; Arteaga Carlos L; Akporiaye Emmanuel T
Transforming growth factor beta inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines.
Cancer research 2003;63(8):1860-4.
2003: Chiosis Gabriela; Huezo Henri; Rosen Neal; Mimnaugh Edward; Whitesell Luke; Neckers Len
17AAG: low target binding affinity and potent cell activity--finding an explanation.
Molecular cancer therapeutics 2003;2(2):123-9.
2003: David Cynthia L; Smith Harold E; Raynes Deborah A; Pulcini Elizabeth J; Whitesell Luke
Expression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegans.
Cell stress & chaperones 2003;8(1):93-104.
2002: Bagatell Rochelle; Morgan Elaine; Cosentino Catherine; Whitesell Luke
Two cases of pediatric neuroblastoma with tumor thrombus in the inferior vena cava.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 2002;24(5):397-400.
2001: Bagatell R; Khan O; Paine-Murrieta G; Taylor C W; Akinaga S; Whitesell L
Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):2076-84.
2001: Feng H; Zeng Y; Whitesell L; Katsanis E
Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity.
Blood 2001;97(11):3505-12.
2001: He L; Feng H; Raymond A; Kreeger M; Zeng Y; Graner M; Whitesell L; Katsanis E
Dendritic-cell-peptide immunization provides immunoprotection against bcr-abl-positive leukemia in mice.
Cancer immunology, immunotherapy : CII 2001;50(1):31-40.
2001: Bennett C L; Christie J; Ramsdell F; Brunkow M E; Ferguson P J; Whitesell L; Kelly T E; Saulsbury F T; Chance P F; Ochs H D
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.
Nature genetics 2001;27(1):20-1.
2000: Bagatell R; Paine-Murrieta G D; Taylor C W; Pulcini E J; Akinaga S; Benjamin I J; Whitesell L
Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(8):3312-8.
2000: Graner M; Raymond A; Romney D; He L; Whitesell L; Katsanis E
Immunoprotective activities of multiple chaperone proteins isolated from murine B-cell leukemia/lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):909-15.
2000: Yorgin P D; Hartson S D; Fellah A M; Scroggins B T; Huang W; Katsanis E; Couchman J M; Matts R L; Whitesell L
Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):2915-23.
2000: Yorgin P D; Eklund D K; al-Uzri A; Whitesell L; Theodorou A A
Concurrent centrifugation plasmapheresis and continuous venovenous hemodiafiltration.
Pediatric nephrology (Berlin, Germany) 2000;14(1):18-21.
1999: Whitesell L; Liu X; Bagatell R
Inhibition of oncogene expression using vector-generated RNA antisense.
Methods (San Diego, Calif.) 1999;18(3):296-303.
1999: Lele Z; Hartson S D; Martin C C; Whitesell L; Matts R L; Krone P H
Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90.
Developmental biology 1999;210(1):56-70.
1999: Hartson S D; Thulasiraman V; Huang W; Whitesell L; Matts R L
Molybdate inhibits hsp90, induces structural changes in its C-terminal domain, and alters its interactions with substrates.
Biochemistry 1999;38(12):3837-49.
1998: Smith D F; Whitesell L; Katsanis E
Molecular chaperones: biology and prospects for pharmacological intervention.
Pharmacological reviews 1998;50(4):493-514.
1998: Liu X; Turbyville T; Fritz A; Whitesell L
Inhibition of insulin-like growth factor I receptor expression in neuroblastoma cells induces the regression of established tumors in mice.
Cancer research 1998;58(23):5432-8.
1998: Slepian M J; Massia S P; Dehdashti B; Fritz A; Whitesell L
Beta3-integrins rather than beta1-integrins dominate integrin-matrix interactions involved in postinjury smooth muscle cell migration.
Circulation 1998;97(18):1818-27.
1998: Whitesell L; Sutphin P D; Pulcini E J; Martinez J D; Cook P H
The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent.
Molecular and cellular biology 1998;18(3):1517-24.
1997: Whitesell L; Sutphin P; An W G; Schulte T; Blagosklonny M V; Neckers L
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.
Oncogene 1997;14(23):2809-16.
1996: Slepian M J; Massia S P; Whitesell L
Pre-conditioning of smooth muscle cells via induction of the heat shock response limits proliferation following mechanical injury.
Biochemical and biophysical research communications 1996;225(2):600-7.
1996: Whitesell L; Cook P
Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells.
Molecular endocrinology (Baltimore, Md.) 1996;10(6):705-12.
1996: Chavany C; Mimnaugh E; Miller P; Bitton R; Nguyen P; Trepel J; Whitesell L; Schnur R; Moyer J; Neckers L
p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.
The Journal of biological chemistry 1996;271(9):4974-7.
1996: Sei Y; Whitesell L; Kustova Y; Paul I A; Morse H C; Skolnick P; Basile A S
Altered brain fyn kinase in a murine acquired immunodeficiency syndrome.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(2):339-44.
1995: Smith D F; Whitesell L; Nair S C; Chen S; Prapapanich V; Rimerman R A
Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent.
Molecular and cellular biology 1995;15(12):6804-12.
1995: Mimnaugh E G; Worland P J; Whitesell L; Neckers L M
Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase.
The Journal of biological chemistry 1995;270(48):28654-9.
1994: Whitesell L; Mimnaugh E G; De Costa B; Myers C E; Neckers L M
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(18):8324-8.
1994: Bang Y J; Pirnia F; Fang W G; Kang W K; Sartor O; Whitesell L; Ha M J; Tsokos M; Sheahan M D; Nguyen P; Niklinski W T; Myers C E; Trepel J B
Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMP.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5330-4.
1993: Neckers L; Whitesell L
Antisense technology: biological utility and practical considerations.
The American journal of physiology 1993;265(1 Pt 1):L1-12.
1993: Whitesell L; Geselowitz D; Chavany C; Fahmy B; Walbridge S; Alger J R; Neckers L M
Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: implications for therapeutic application within the central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4665-9.
1992: Neckers L; Rosolen A; Fahmy B; Whitesell L
Specific inhibition of oncogene expression in vitro and in vivo by antisense oligonucleotides.
Annals of the New York Academy of Sciences 1992;660():37-44.
1992: Neckers L M; Rosolen A; Whitesell L
Antisense inhibition of gene expression: a tool for studying the role of NMYC in the growth and differentiation of neuroectoderm-derived cells.
Journal of immunotherapy : official journal of the Society for Biological Therapy 1992;12(3):162-6.
1992: Whitesell L; Shifrin S D; Schwab G; Neckers L M
Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition.
Cancer research 1992;52(7):1721-8.
1992: Rosolen A; Colamonici O R; Pfeffer L M; Whitesell L; Nordan R; Neckers L M
Detection of functional interferon alpha receptors in human neuroendocrine tumor cell lines using a new monoclonal antibody.
European cytokine network 1992;3(2):81-8.
1992: Neckers L; Whitesell L; Rosolen A; Geselowitz D A
Antisense inhibition of oncogene expression.
Critical reviews in oncogenesis 1992;3(1-2):175-231.
1991: Whitesell L; Rosolen A; Neckers L M
Episome-generated N-myc antisense RNA restricts the differentiation potential of primitive neuroectodermal cell lines.
Molecular and cellular biology 1991;11(3):1360-71.
1991: Whitesell L; Rosolen A; Neckers L M
Antisense suppression of N-myc expression inhibits the transdifferentiation of neuroectoderm tumor cell lines.
Progress in clinical and biological research 1991;366():45-54.
1991: Rosolen A; Whitesell L; Ikegaki N; Kennett R; Neckers L M
Antisense inhibition of N-myc reduces cell growth but does not affect c-myc expression in the neuroepithelioma cell line CHP100.
Progress in clinical and biological research 1991;366():29-36.
1991: Whitesell L; Rosolen A; Neckers L M
In vivo modulation of N-myc expression by continuous perfusion with an antisense oligonucleotide.
Antisense research and development 1991;1(4):343-50.
1990: Rosolen A; Whitesell L; Ikegaki N; Kennett R H; Neckers L M
Antisense inhibition of single copy N-myc expression results in decreased cell growth without reduction of c-myc protein in a neuroepithelioma cell line.
Cancer research 1990;50(19):6316-22.

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