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Malcolm Whiteway

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TOP 3
Volodymyr Yerko; Jason Baardsnes; Miroslaw Cygler; Irena Ekiel; Doreen Harcus; Traian Sulea; Malcolm Whiteway; Cunle Wu
Structurally unique interaction of RBD-like and PH domains is crucial for yeast pheromone signaling.
Jessica V Pierce; Malcolm Whiteway; Daniel Dignard; Carol A Kumamoto
Normal adaptation of Candida albicans to the murine gastrointestinal tract requires Efg1p-dependent regulation of metabolic and host defense genes.
Owen Ryan; Tobias Schwarzmüller; A Sellam; Rebecca S Shapiro; Faiza Tebbji; Kyle Tsui; Frederick Vizeacoumar; Malcolm Whiteway; Brenda Andrews; Sondra Bahr; Anastasia Baryshnikova; Doris Cheung; Brian Chin; Michael Costanzo; Leah E Cowen; Michael J Cox; Gerald R Fink; Guri Giaever; David K Gifford; Anne-Claude Gingras; Fabian Istel; Karl Kuchler; Christoph F Kurat; Zhen-Yuan Lin; David Mayhew; Robi D Mitra; Corey Nislow; Todd B Reynolds; Charles Boone
Global gene deletion analysis exploring yeast filamentous growth.

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All Publications

2013: Volodymyr Yerko; Jason Baardsnes; Miroslaw Cygler; Irena Ekiel; Doreen Harcus; Traian Sulea; Malcolm Whiteway; Cunle Wu
Structurally unique interaction of RBD-like and PH domains is crucial for yeast pheromone signaling.
Molecular biology of the cell 2013;24(3):409-20.
2013: Jessica V Pierce; Malcolm Whiteway; Daniel Dignard; Carol A Kumamoto
Normal adaptation of Candida albicans to the murine gastrointestinal tract requires Efg1p-dependent regulation of metabolic and host defense genes.
Eukaryotic cell 2013;12(1):37-49.
2012: Owen Ryan; Tobias Schwarzmüller; A Sellam; Rebecca S Shapiro; Faiza Tebbji; Kyle Tsui; Frederick Vizeacoumar; Malcolm Whiteway; Brenda Andrews; Sondra Bahr; Anastasia Baryshnikova; Doris Cheung; Brian Chin; Michael Costanzo; Leah E Cowen; Michael J Cox; Gerald R Fink; Guri Giaever; David K Gifford; Anne-Claude Gingras; Fabian Istel; Karl Kuchler; Christoph F Kurat; Zhen-Yuan Lin; David Mayhew; Robi D Mitra; Corey Nislow; Todd B Reynolds; Charles Boone
Global gene deletion analysis exploring yeast filamentous growth.
Science (New York, N.Y.) 2012;337(6100):1353-6.
2012: Nadezda Kachurina; Bernard Turcotte; Malcolm Whiteway
Motor protein Myo5p is required to maintain the regulatory circuit controlling WOR1 expression in Candida albicans.
Eukaryotic cell 2012;11(5):626-37.
2012: Rebecca S Shapiro; Faiza Tebbji; Malcolm Whiteway; André Nantel; A Sellam; Leah E Cowen
Pho85, Pcl1, and Hms1 signaling governs Candida albicans morphogenesis induced by high temperature or Hsp90 compromise.
Current biology : CB 2012;22(6):461-70.
2012: A Sellam; Faiza Tebbji; Malcolm Whiteway; André Nantel
A novel role for the transcription factor Cwt1p as a negative regulator of nitrosative stress in Candida albicans.
PloS one 2012;7(8):e43956.
2011: Malcolm Whiteway
Yeast mating: trying out new pickup lines.
Current biology : CB 2011;21(16):R626-8.
2011: Christopher Askew; A Sellam; Elias Epp; Jaideep Mallick; Hervé Hogues; Alaka Mullick; André Nantel; Malcolm Whiteway
The zinc cluster transcription factor Ahr1p directs Mcm1p regulation of Candida albicans adhesion.
Molecular microbiology 2011;79(4):940-53.
2010: Ari Rosenbach; Daniel Dignard; Jessica V Pierce; Malcolm Whiteway; Carol A Kumamoto
Adaptations of Candida albicans for growth in the mammalian intestinal tract.
Eukaryotic cell 2010;9(7):1075-86.
2010: A Sellam; Christopher Askew; Elias Epp; Faiza Tebbji; Alaka Mullick; Malcolm Whiteway; André Nantel
Role of transcription factor CaNdt80p in cell separation, hyphal growth, and virulence in Candida albicans.
Eukaryotic cell 2010;9(4):634-44.
2010: Hugo Lavoie; Hervé Hogues; Jaideep Mallick; A Sellam; André Nantel; Malcolm Whiteway
Evolutionary tinkering with conserved components of a transcriptional regulatory network.
PLoS biology 2010;8(3):e1000329.
2010: Elias Epp; Andrea Walther; Guylaine Lépine; Zully Leon; Alaka Mullick; Martine Raymond; Jürgen Wendland; Malcolm Whiteway
Forward genetics in Candida albicans that reveals the Arp2/3 complex is required for hyphal formation, but not endocytosis.
Molecular microbiology 2010;75(5):1182-98.
2010: Elias Epp; Ghyslaine Vanier; Doreen Harcus; Anna Y Lee; Gregor Jansen; Michael Hallett; Don C Sheppard; David Y Thomas; Carol A Munro; Alaka Mullick; Malcolm Whiteway
Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence.
PLoS pathogens 2010;6(2):e1000753.
2010: A Sellam; Hervé Hogues; Christopher Askew; Faiza Tebbji; Marco van Het Hoog; Hugo Lavoie; Carol A Kumamoto; Malcolm Whiteway; André Nantel
Experimental annotation of the human pathogen Candida albicans coding and noncoding transcribed regions using high-resolution tiling arrays.
Genome biology 2010;11(7):R71.
2009: Hugo Lavoie; Hervé Hogues; Malcolm Whiteway
Rearrangements of the transcriptional regulatory networks of metabolic pathways in fungi.
Current opinion in microbiology 2009;12(6):655-63.
2009: Irena Ekiel; Traian Sulea; Gregor Jansen; Maria Kowalik; Ovidiu Minailiuc; Jing Cheng; Doreen Harcus; Miroslaw Cygler; Malcolm Whiteway; Cunle Wu
Binding the atypical RA domain of Ste50p to the unfolded Opy2p cytoplasmic tail is essential for the high-osmolarity glycerol pathway.
Molecular biology of the cell 2009;20(24):5117-26.
2009: Christopher Askew; A Sellam; Elias Epp; Hervé Hogues; Alaka Mullick; André Nantel; Malcolm Whiteway
Transcriptional regulation of carbohydrate metabolism in the human pathogen Candida albicans.
PLoS pathogens 2009;5(10):e1000612.
2009: Mélanie Arbour; Elias Epp; Hervé Hogues; A Sellam; Celine Lacroix; Jason Rauceo; Aaron Mitchell; Malcolm Whiteway; André Nantel
Widespread occurrence of chromosomal aneuploidy following the routine production of Candida albicans mutants.
FEMS yeast research 2009;9(7):1070-7.
2009: Pierre Côte; Hervé Hogues; Malcolm Whiteway
Transcriptional analysis of the Candida albicans cell cycle.
Molecular biology of the cell 2009;20(14):3363-73.
2009: A Sellam; Christopher Askew; Elias Epp; Hugo Lavoie; Malcolm Whiteway; André Nantel
Genome-wide mapping of the coactivator Ada2p yields insight into the functional roles of SAGA/ADA complex in Candida albicans.
Molecular biology of the cell 2009;20(9):2389-400.
2009: Malcolm Whiteway
Yeast mating: putting some fizz into fungal sex?
Current biology : CB 2009;19(6):R258-60.
2009: Gregor Jansen; Anna Y Lee; Elias Epp; Amélie Fredette; Jamie Surprenant; Doreen Harcus; Michelle Scott; Elaine Tan; Tamiko Nishimura; Malcolm Whiteway; Michael Hallett; David Y Thomas
Chemogenomic profiling predicts antifungal synergies.
Molecular systems biology 2009;5():338.
2009: Robert B Annan; Anna Y Lee; Ian D Reid; Azin Sayad; Malcolm Whiteway; Michael Hallett; David Y Thomas
A biochemical genomics screen for substrates of Ste20p kinase enables the in silico prediction of novel substrates.
PloS one 2009;4(12):e8279.
2008: Daniel Dignard; Dominique André; Malcolm Whiteway
Heterotrimeric G-protein subunit function in Candida albicans: both the alpha and beta subunits of the pheromone response G protein are required for mating.
Eukaryotic cell 2008;7(9):1591-9.
2008: Anne Marcil; C Gadoury; Josee Ash; J Zhang; André Nantel; Malcolm Whiteway
Analysis of PRA1 and its relationship to Candida albicans- macrophage interactions.
Infection and immunity 2008;76(9):4345-58.
2008: Robert B Annan; Cunle Wu; Daniel D Waller; Malcolm Whiteway; David Y Thomas
Rho5p is involved in mediating the osmotic stress response in Saccharomyces cerevisiae, and its activity is regulated via Msi1p and Npr1p by phosphorylation and ubiquitination.
Eukaryotic cell 2008;7(9):1441-9.
2008: Hugo Lavoie; Malcolm Whiteway
Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span.
Eukaryotic cell 2008;7(7):1127-35.
2008: Anastasia Levitin; Malcolm Whiteway
Drosophila innate immunity and response to fungal infections.
Cellular microbiology 2008;10(5):1021-6.
2008: Pierre Côte; Malcolm Whiteway
The role of Candida albicans FAR1 in regulation of pheromone-mediated mating, gene expression and cell cycle arrest.
Molecular microbiology 2008;68(2):392-404.
2008: Hervé Hogues; Hugo Lavoie; A Sellam; Maria Mangos; Terry Roemer; Enrico Purisima; André Nantel; Malcolm Whiteway
Transcription factor substitution during the evolution of fungal ribosome regulation.
Molecular cell 2008;29(5):552-62.
2008: Hugo Lavoie; A Sellam; Christopher Askew; André Nantel; Malcolm Whiteway
A toolbox for epitope-tagging and genome-wide location analysis in Candida albicans.
BMC genomics 2008;9():578.
2008: Hao Huang; Doreen Harcus; Malcolm Whiteway
Transcript profiling of a MAP kinase pathway in C. albicans.
Microbiological research 2008;163(4):380-93.
2007: Sarah Jane White; Ari Rosenbach; Paul Lephart; Diem Nguyen; Alana Benjamin; Saul Tzipori; Malcolm Whiteway; Joan Mecsas; Carol A Kumamoto
Self-regulation of Candida albicans population size during GI colonization.
PLoS pathogens 2007;3(12):e184.
2007: Sem Kebache; Josee Ash; Matthew G Annis; John Patrick Hagan; Maria Huber; Jennifer Hassard; Colin L Stewart; Malcolm Whiteway; André Nantel
Grb10 and active Raf-1 kinase promote Bad-dependent cell survival.
The Journal of biological chemistry 2007;282(30):21873-83.
2007: Mikhail Martchenko; Anastasia Levitin; Herve Hogues; André Nantel; Malcolm Whiteway
Transcriptional rewiring of fungal galactose-metabolism circuitry.
Current biology : CB 2007;17(12):1007-13.
2007: C Patrick Lusk; Daniel D Waller; Taras Makhnevych; Axel Dienemann; Malcolm Whiteway; David Y Thomas; Richard W Wozniak
Nup53p is a target of two mitotic kinases, Cdk1p and Hrr25p.
Traffic (Copenhagen, Denmark) 2007;8(6):647-60.
2007: Dana Schaefer; Pierre Côte; Malcolm Whiteway; Richard J Bennett
Barrier activity in Candida albicans mediates pheromone degradation and promotes mating.
Eukaryotic cell 2007;6(6):907-18.
2007: Anastasia Levitin; Anne Marcil; Gritta Tettweiler; M J Laforest; Ursula Oberholzer; Anne-Marie Alarco; David Y Thomas; Paul Lasko; Malcolm Whiteway
Drosophila melanogaster Thor and response to Candida albicans infection.
Eukaryotic cell 2007;6(4):658-63.
2007: Raluca Dumitru; Dhammika H M L P Navarathna; Camile P Semighini; Christian G Elowsky; Razvan V Dumitru; Daniel Dignard; Malcolm Whiteway; Audrey L Atkin; Kenneth W Nickerson
In vivo and in vitro anaerobic mating in Candida albicans.
Eukaryotic cell 2007;6(3):465-72.
2007: Daniel Dignard; Ahmed L El-Naggar; Mary E Logue; Geraldine Butler; Malcolm Whiteway
Identification and characterization of MFA1, the gene encoding Candida albicans a-factor pheromone.
Eukaryotic cell 2007;6(3):487-94.
2007: Jihong Wang; Zhihui Yan; Shi-Hsiang Shen; Malcolm Whiteway; Linghuo Jiang
Expression of CaPTC7 is developmentally regulated during serum-induced morphogenesis in the human fungal pathogen Candida albicans.
Canadian journal of microbiology 2007;53(2):237-44.
2007: Mikhail Martchenko; Anastasia Levitin; Malcolm Whiteway
Transcriptional activation domains of the Candida albicans Gcn4p and Gal4p homologs.
Eukaryotic cell 2007;6(2):291-301.
2007: Malcolm Whiteway; Catherine Bachewich
Morphogenesis in Candida albicans.
Annual review of microbiology 2007;61():529-53.
2007: Anastasia Levitin; Malcolm Whiteway
The effect of prostaglandin E2 on transcriptional responses of Candida albicans.
Microbiological research 2007;162(3):201-10.
2007: Marco van het Hoog; Timothy J Rast; Mikhail Martchenko; Suzanne Grindle; Daniel Dignard; Hervé Hogues; Christine Cuomo; Matthew Berriman; Stewart Scherer; Beatrice B Magee; Malcolm Whiteway; Hiroji Chibana; André Nantel; Paul T Magee
Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.
Genome biology 2007;8(4):R52.
2006: Ursula Oberholzer; André Nantel; Judith Berman; Malcolm Whiteway
Transcript profiles of Candida albicans cortical actin patch mutants reflect their cellular defects: contribution of the Hog1p and Mkc1p signaling pathways.
Eukaryotic cell 2006;5(8):1252-65.
2006: Meiqun Wu; Zhenbao Yu; Jinjiang Fan; Antoine Caron; Malcolm Whiteway; Shi-Hsiang Shen
Functional dissection of human protease mu-calpain in cell migration using RNAi.
FEBS letters 2006;580(13):3246-56.
2006: Roger O Ebanks; Kenneth Chisholm; Stewart McKinnon; Malcolm Whiteway; Devanand M Pinto
Proteomic analysis of Candida albicans yeast and hyphal cell wall and associated proteins.
Proteomics 2006;6(7):2147-56.
2006: Cunle Wu; Gregor Jansen; Jianchun Zhang; David Y Thomas; Malcolm Whiteway
Adaptor protein Ste50p links the Ste11p MEKK to the HOG pathway through plasma membrane association.
Genes & development 2006;20(6):734-46.
2006: Daniel Dignard; Malcolm Whiteway
SST2, a regulator of G-protein signaling for the Candida albicans mating response pathway.
Eukaryotic cell 2006;5(1):192-202.
2005: Min-Sung Kim; Min-Ju Yi; Kwang-Hoon Lee; John Wagner; Christine Munger; Yeon-Gil Kim; Malcolm Whiteway; Miroslaw Cygler; Byung-Ha Oh; Michael Sacher
Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p.
Traffic (Copenhagen, Denmark) 2005;6(12):1183-95.
2005: Catherine Bachewich; André Nantel; Malcolm Whiteway
Cell cycle arrest during S or M phase generates polarized growth via distinct signals in Candida albicans.
Molecular microbiology 2005;57(4):942-59.
2005: Brice Enjalbert; Malcolm Whiteway
Release from quorum-sensing molecules triggers hyphal formation during Candida albicans resumption of growth.
Eukaryotic cell 2005;4(7):1203-10.
2005: Jinjiang Fan; Malcolm Whiteway; Shi-Hsiang Shen
Disruption of a gene encoding glycerol 3-phosphatase from Candida albicans impairs intracellular glycerol accumulation-mediated salt-tolerance.
FEMS microbiology letters 2005;245(1):107-16.
2005: Gregor Jansen; Cunle Wu; Babette Schade; David Y Thomas; Malcolm Whiteway
Drag&Drop cloning in yeast.
Gene 2005;344():43-51.
2005: Catherine Bachewich; Malcolm Whiteway
Cyclin Cln3p links G1 progression to hyphal and pseudohyphal development in Candida albicans.
Eukaryotic cell 2005;4(1):95-102.
2005: Yeon-Gil Kim; Eun Ju Sohn; Jawon Seo; Kong-Joo Lee; Heung-Soo Lee; Inhwan Hwang; Malcolm Whiteway; Michael Sacher; Byung-Ha Oh
Crystal structure of bet3 reveals a novel mechanism for Golgi localization of tethering factor TRAPP.
Nature structural & molecular biology 2005;12(1):38-45.
2004: Surajit Bhattacharjya; Ping Xu; Richard Gingras; Rustem Shaykhutdinov; Cunle Wu; Malcolm Whiteway; Feng Ni
Solution structure of the dimeric SAM domain of MAPKKK Ste11 and its interactions with the adaptor protein Ste50 from the budding yeast: implications for Ste11 activation and signal transmission through the Ste50-Ste11 complex.
Journal of molecular biology 2004;344(4):1071-87.
2004: Babette Schade; Gregor Jansen; Malcolm Whiteway; Karl D Entian; David Y Thomas
Cold adaptation in budding yeast.
Molecular biology of the cell 2004;15(12):5492-502.
2004: Ursula Oberholzer; Tatiana Iouk; David Y Thomas; Malcolm Whiteway
Functional characterization of myosin I tail regions in Candida albicans.
Eukaryotic cell 2004;3(5):1272-86.
2004: Susan Nicholls; Melissa Straffon; Brice Enjalbert; André Nantel; Susan Macaskill; Malcolm Whiteway; Alistair J P Brown
Msn2- and Msn4-like transcription factors play no obvious roles in the stress responses of the fungal pathogen Candida albicans.
Eukaryotic cell 2004;3(5):1111-23.
2004: Doreen Harcus; André Nantel; Anne Marcil; Tracey Rigby; Malcolm Whiteway
Transcription profiling of cyclic AMP signaling in Candida albicans.
Molecular biology of the cell 2004;15(10):4490-9.
2004: Malcolm Whiteway; Ursula Oberholzer
Candida morphogenesis and host-pathogen interactions.
Current opinion in microbiology 2004;7(4):350-7.
2004: Anne-Marie Alarco; Anne Marcil; Jian Chen; Beat Suter; David Thomas; Malcolm Whiteway
Immune-deficient Drosophila melanogaster: a model for the innate immune response to human fungal pathogens.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5622-8.
2004: Chang-Muk Lee; André Nantel; Linghuo Jiang; Malcolm Whiteway; Shi-Hsiang Shen
The serine/threonine protein phosphatase SIT4 modulates yeast-to-hypha morphogenesis and virulence in Candida albicans.
Molecular microbiology 2004;51(3):691-709.
2004: Mikhail Martchenko; Anne-Marie Alarco; Doreen Harcus; Malcolm Whiteway
Superoxide dismutases in Candida albicans: transcriptional regulation and functional characterization of the hyphal-induced SOD5 gene.
Molecular biology of the cell 2004;15(2):456-67.
2004: Alaka Mullick; Miria Elias; Penelope Harakidas; Anne Marcil; Malcolm Whiteway; Bing Ge; Thomas J Hudson; Antoine W Caron; Lucie Bourget; Serge Picard; Orce Jovcevski; Bernard Massie; David Y Thomas
Gene expression in HL60 granulocytoids and human polymorphonuclear leukocytes exposed to Candida albicans.
Infection and immunity 2004;72(1):414-29.
2003: Sneh L Panwar; Melanie Legrand; Daniel Dignard; Malcolm Whiteway; Paul T Magee
MFalpha1, the gene encoding the alpha mating pheromone of Candida albicans.
Eukaryotic cell 2003;2(6):1350-60.
2003: Cunle Wu; Mathieu Arcand; Gregor Jansen; Mei Zhong; Tatiana Iouk; David Y Thomas; Sylvain Meloche; Malcolm Whiteway
Phosphorylation of the MAPKKK regulator Ste50p in Saccharomyces cerevisiae: a casein kinase I phosphorylation site is required for proper mating function.
Eukaryotic cell 2003;2(5):949-61.
2003: Gary B Dunphy; Ursula Oberholzer; Malcolm Whiteway; Robert J Zakarian; Iian Boomer
Virulence of Candida albicans mutants toward larval Galleria mellonella (Insecta, Lepidoptera, Galleridae).
Canadian journal of microbiology 2003;49(8):514-24.
2003: Catherine Bachewich; David Y Thomas; Malcolm Whiteway
Depletion of a polo-like kinase in Candida albicans activates cyclase-dependent hyphal-like growth.
Molecular biology of the cell 2003;14(5):2163-80.
2003: Brice Enjalbert; André Nantel; Malcolm Whiteway
Stress-induced gene expression in Candida albicans: absence of a general stress response.
Molecular biology of the cell 2003;14(4):1460-7.
2003: Kailesh Gopalbhai; Gregor Jansen; Geneviève Beauregard; Malcolm Whiteway; France Dumas; Cunle Wu; Sylvain Meloche
Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1.
The Journal of biological chemistry 2003;278(10):8118-25.
2003: Christina Kast; Minglun Wang; Malcolm Whiteway
The ERK/MAPK pathway regulates the activity of the human tissue factor pathway inhibitor-2 promoter.
The Journal of biological chemistry 2003;278(9):6787-94.
2003: Josée Ash; Cunle Wu; Robert Larocque; Maleek Jamal; Willem Stevens; Mike Osborne; David Y Thomas; Malcolm Whiteway
Genetic analysis of the interface between Cdc42p and the CRIB domain of Ste20p in Saccharomyces cerevisiae.
Genetics 2003;163(1):9-20.
2002: Anne Marcil; Doreen Harcus; David Y Thomas; Malcolm Whiteway
Candida albicans killing by RAW 264.7 mouse macrophage cells: effects of Candida genotype, infection ratios, and gamma interferon treatment.
Infection and immunity 2002;70(11):6319-29.
2002: Marc Brennan; David Y Thomas; Malcolm Whiteway; Kevin Kavanagh
Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae.
FEMS immunology and medical microbiology 2002;34(2):153-7.
2002: André Nantel; Daniel Dignard; Catherine Bachewich; Doreen Harcus; Anne Marcil; Anne-Pascale Bouin; Christoph Wilhelm Sensen; Hervé Hogues; Marco van het Hoog; Paul Gordon; Tracey Rigby; François Benoit; Daniel C Tessier; David Y Thomas; Malcolm Whiteway
Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transition.
Molecular biology of the cell 2002;13(10):3452-65.
2002: Sonja Michel; Sophia C Ushinsky; Bert Klebl; Ekkehard Leberer; David Thomas; Malcolm Whiteway; Joachim Morschhäuser
Generation of conditional lethal Candida albicans mutants by inducible deletion of essential genes.
Molecular microbiology 2002;46(1):269-80.
2002: Linghuo Jiang; Malcolm Whiteway; Carlos w Ramos; Jose R Rodriguez-Medina; Shi-Hsiang Shen
The YHR076w gene encodes a type 2C protein phosphatase and represents the seventh PP2C gene in budding yeast.
FEBS letters 2002;527(1-3):323-5.
2002: Ursula Oberholzer; Anne Marcil; Ekkehard Leberer; David Y Thomas; Malcolm Whiteway
Myosin I is required for hypha formation in Candida albicans.
Eukaryotic cell 2002;1(2):213-28.
2002: Sophia C Ushinsky; Doreen Harcus; Josee Ash; Daniel Dignard; Anne Marcil; Joachim Morchhauser; David Y Thomas; Malcolm Whiteway; Ekkehard Leberer
CDC42 is required for polarized growth in human pathogen Candida albicans.
Eukaryotic cell 2002;1(1):95-104.
2002: Gregor Jansen; Ekkehard Leberer; David Y Thomas; Malcolm Whiteway
Use of dominant negative mutations in analysis of G protein function in Saccharomyces cerevisiae.
Methods in enzymology 2002;344():82-91.
2001: C R Rocha; Klaus Schröppel; Doreen Harcus; Anne Marcil; Daniel Dignard; Brad N Taylor; David Y Thomas; Malcolm Whiteway; Ekkehard Leberer
Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans.
Molecular biology of the cell 2001;12(11):3631-43.
2000: Klaus Schröppel; K Sprösser; Malcolm Whiteway; David Y Thomas; Martin Röllinghoff; C Csank
Repression of hyphal proteinase expression by the mitogen-activated protein (MAP) kinase phosphatase Cpp1p of Candida albicans is independent of the MAP kinase Cek1p.
Infection and immunity 2000;68(12):7159-61.
2000: Martine Raymond; Daniel Dignard; Anne-Marie Alarco; K L Clark; Sandra Weber; Malcolm Whiteway; Ekkehard Leberer; David Y Thomas
Molecular cloning of the CRM1 gene from Candida albicans.
Yeast (Chichester, England) 2000;16(6):531-8.
2000: Marie Evangelista; Bert Klebl; Amy Hin Yan Tong; Bradley A Webb; T Leeuw; Ekkehard Leberer; Malcolm Whiteway; David Y Thomas; Charles Boone
A role for myosin-I in actin assembly through interactions with Vrp1p, Bee1p, and the Arp2/3 complex.
The Journal of cell biology 2000;148(2):353-62.
1999: Carl Wu; Ekkehard Leberer; David Y Thomas; Malcolm Whiteway
Functional characterization of the interaction of Ste50p with Ste11p MAPKKK in Saccharomyces cerevisiae.
Molecular biology of the cell 1999;10(7):2425-40.
1998: Faisal Guhad; C Csank; Henrik Elvang Jensen; D Y Thomas; Malcolm Whiteway; Jann Hau
Reduced pathogenicity of a Candida albicans MAP kinase phosphatase (CPP1) mutant in the murine mastitis model.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1998;106(11):1049-55.
1998: Carl Wu; T Leeuw; Ekkehard Leberer; David Y Thomas; Malcolm Whiteway
Cell cycle- and Cln2p-Cdc28p-dependent phosphorylation of the yeast Ste20p protein kinase.
The Journal of biological chemistry 1998;273(43):28107-15.
1998: Faisal Guhad; Henrik Elvang Jensen; Bent Aalbaek; C Csank; O Mohamed; Doreen Harcus; D Y Thomas; Malcolm Whiteway; Jann Hau
Mitogen-activated protein kinase-defective Candida albicans is avirulent in a novel model of localized murine candidiasis.
FEMS microbiology letters 1998;166(1):135-9.
1998: C Csank; Klaus Schröppel; Ekkehard Leberer; Doreen Harcus; O Mohamed; Sylvain Meloche; David Y Thomas; Malcolm Whiteway
Roles of the Candida albicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasis.
Infection and immunity 1998;66(6):2713-21.
1998: T Leeuw; Carl Wu; Joseph D Schrag; Malcolm Whiteway; David Y Thomas; Ekkehard Leberer
Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases.
Nature 1998;391(6663):191-5.
1997: C Csank; Constantin Makris; Sylvain Meloche; Klaus Schröppel; M Röllinghoff; Daniel Dignard; David Y Thomas; Malcolm Whiteway
Derepressed hyphal growth and reduced virulence in a VH1 family-related protein phosphatase mutant of the human pathogen Candida albicans.
Molecular biology of the cell 1997;8(12):2539-51.
1997: Ekkehard Leberer; David Y Thomas; Malcolm Whiteway
Pheromone signalling and polarized morphogenesis in yeast.
Current opinion in genetics & development 1997;7(1):59-66.
1995: K L Clark; P J Feldmann; Daniel Dignard; R Larocque; A J Brown; M G Lee; David Y Thomas; Malcolm Whiteway
Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans.
Molecular & general genetics : MGG 1995;249(6):609-21.
1995: T Leeuw; A Fourest-Lieuvin; Carl Wu; J Chenevert; K Clark; Malcolm Whiteway; David Y Thomas; Ekkehard Leberer
Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin.
Science (New York, N.Y.) 1995;270(5239):1210-3.
1995: Malcolm Whiteway; Carl Wu; T Leeuw; K Clark; A Fourest-Lieuvin; David Y Thomas; Ekkehard Leberer
Association of the yeast pheromone response G protein beta gamma subunits with the MAP kinase scaffold Ste5p.
Science (New York, N.Y.) 1995;269(5230):1572-5.
1995: Carl Wu; Malcolm Whiteway; David Y Thomas; Ekkehard Leberer
Molecular characterization of Ste20p, a potential mitogen-activated protein or extracellular signal-regulated kinase kinase (MEK) kinase kinase from Saccharomyces cerevisiae.
The Journal of biological chemistry 1995;270(27):15984-92.
1994: Malcolm Whiteway; David Y Thomas
Site-directed mutations altering the CAAX box of Ste18, the yeast pheromone-response pathway G gamma subunit.
Genetics 1994;137(4):967-76.
1994: Ekkehard Leberer; Daniel Dignard; Doreen Harcus; Malcolm Whiteway; David Y Thomas
Molecular characterization of SIG1, a Saccharomyces cerevisiae gene involved in negative regulation of G-protein-mediated signal transduction.
The EMBO journal 1994;13(13):3050-64.
1994: Malcolm Whiteway; K L Clark; Ekkehard Leberer; Daniel Dignard; David Y Thomas
Genetic identification of residues involved in association of alpha and beta G-protein subunits.
Molecular and cellular biology 1994;14(5):3223-9.
1993: Ekkehard Leberer; Daniel Dignard; Doreen Harcus; L Hougan; Malcolm Whiteway; David Y Thomas
Cloning of Saccharomyces cerevisiae STE5 as a suppressor of a Ste20 protein kinase mutant: structural and functional similarity of Ste5 to Far1.
Molecular & general genetics : MGG 1993;241(3-4):241-54.
1993: K L Clark; Daniel Dignard; David Y Thomas; Malcolm Whiteway
Interactions among the subunits of the G protein involved in Saccharomyces cerevisiae mating.
Molecular and cellular biology 1993;13(1):1-8.
1992: Ekkehard Leberer; Daniel Dignard; Doreen Harcus; David Y Thomas; Malcolm Whiteway
The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.
The EMBO journal 1992;11(13):4815-24.
1992: Ekkehard Leberer; Daniel Dignard; L Hougan; David Y Thomas; Malcolm Whiteway
Dominant-negative mutants of a yeast G-protein beta subunit identify two functional regions involved in pheromone signalling.
The EMBO journal 1992;11(13):4805-13.
1992: Malcolm Whiteway; Daniel Dignard; David Y Thomas
Dominant negative selection of heterologous genes: isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrest.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9410-4.
1992: Malcolm Whiteway; Daniel Dignard; David Y Thomas
Mutagenesis of Ste18, a putative G gamma subunit in the Saccharomyces cerevisiae pheromone response pathway.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1992;70(10-11):1230-7.
1991: Daniel Dignard; Malcolm Whiteway; D Germain; Daniel C Tessier; David Y Thomas
Expression in yeast of a cDNA copy of the K2 killer toxin gene.
Molecular & general genetics : MGG 1991;227(1):127-36.
1990: Malcolm Whiteway; L Hougan; David Y Thomas
Overexpression of the STE4 gene leads to mating response in haploid Saccharomyces cerevisiae.
Molecular and cellular biology 1990;10(1):217-22.
1989: L Hougan; David Y Thomas; Malcolm Whiteway
Cloning and characterization of the SKI3 gene of Saccharomyces cerevisiae demonstrates allelism to SKI5.
Current genetics 1989;16(3):139-43.
1989: Malcolm Whiteway; L Hougan; Daniel Dignard; David Y Thomas; L Bell; G C Saari; F J Grant; P O'Hara; V L MacKay
The STE4 and STE18 genes of yeast encode potential beta and gamma subunits of the mating factor receptor-coupled G protein.
Cell 1989;56(3):467-77.
1988: Malcolm Whiteway; L Hougan; David Y Thomas
Expression of MF alpha 1 in MATa cells supersensitive to alpha-factor leads to self-arrest.
Molecular & general genetics : MGG 1988;214(1):85-8.
1988: Malcolm Whiteway; L Hougan; Daniel Dignard; L Bell; G Saari; F Grant; P O'Hara; V L MacKay; David Y Thomas
Function of the STE4 and STE18 genes in mating pheromone signal transduction in Saccharomyces cerevisiae.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():585-90.