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Ruth Whitham

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E Kim; Jesus Lovera; L Schaben; Dennis N Bourdette; M Cameron; Ruth H Whitham
American ginseng does not improve fatigue in multiple sclerosis: a single center randomized double-blind placebo-controlled crossover pilot study.
Andrew J Solomon; Ruth H Whitham
Multiple sclerosis and vitamin D: a review and recommendations.
J F Lovera; E Frohman; T R Brown; D Bandari; L Nguyen; Vijayshree Yadav; O Stuve; J Karman; K Bogardus; G Heimburger; L Cua; G Remingon; J Fowler; T Monahan; S Kilcup; Y Courtney; J McAleenan; K Butler; Katherine Wild; Ruth H Whitham; Dennis N Bourdette
Memantine for cognitive impairment in multiple sclerosis: a randomized placebo-controlled trial.

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All Publications

2011: E Kim; Jesus Lovera; L Schaben; Dennis N Bourdette; M Cameron; Ruth H Whitham
American ginseng does not improve fatigue in multiple sclerosis: a single center randomized double-blind placebo-controlled crossover pilot study.
Multiple sclerosis (Houndmills, Basingstoke, England) 2011;17(12):1523-6.
2010: Andrew J Solomon; Ruth H Whitham
Multiple sclerosis and vitamin D: a review and recommendations.
Current neurology and neuroscience reports 2010;10(5):389-96.
2010: J F Lovera; E Frohman; T R Brown; D Bandari; L Nguyen; Vijayshree Yadav; O Stuve; J Karman; K Bogardus; G Heimburger; L Cua; G Remingon; J Fowler; T Monahan; S Kilcup; Y Courtney; J McAleenan; K Butler; Katherine Wild; Ruth H Whitham; Dennis N Bourdette
Memantine for cognitive impairment in multiple sclerosis: a randomized placebo-controlled trial.
Multiple sclerosis (Houndmills, Basingstoke, England) 2010;16(6):715-23.
2010: Eric Edgar; Randall L Woltjer; Ruth H Whitham; Sakir Humayun Gultekin; Suzanne Watnick; Edward Cupler
Nephrogenic systemic fibrosis presenting as myopathy: a case report with histopathologic correlation.
Neuromuscular disorders : NMD 2010;20(6):411-3.
2010: Dennis N Bourdette; Ruth H Whitham
Immunotherapy and multiple sclerosis: The devil is in the details.
Neurology 2010;74(18):1410-1.
2010: Edward Kim; Jesus Lovera; Laura Schaben; J Melara; Dennis N Bourdette; Ruth H Whitham
Novel method for measurement of fatigue in multiple sclerosis: Real-Time Digital Fatigue Score.
Journal of rehabilitation research and development 2010;47(5):477-84.
2008: Keith W Wegmann; Cynthia R Wagner; Ruth H Whitham; David J Hinrichs
Synthetic Peptide dendrimers block the development and expression of experimental allergic encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(5):3301-9.
2008: Arthur Vandenbark; Nicole Culbertson; Richard Bartholomew; Jianya Huan; Marci Agotsch; Dorian LaTocha; Vijayshree Yadav; Michele K Mass; Ruth H Whitham; Jesus Lovera; June Milano; Georgia Theofan; Yuan K Chou; Halina Offner; Dennis N Bourdette
Therapeutic vaccination with a trivalent T-cell receptor (TCR) peptide vaccine restores deficient FoxP3 expression and TCR recognition in subjects with multiple sclerosis.
Immunology 2008;123(1):66-78.
2007: Jesus Lovera; Bridget Bagert; K Smoot; Cynthia Morris; R Frank; Kristin Bogardus; Katherine Wild; Barry S Oken; Ruth H Whitham; Dennis N Bourdette
Ginkgo biloba for the improvement of cognitive performance in multiple sclerosis: a randomized, placebo-controlled trial.
Multiple sclerosis (Houndmills, Basingstoke, England) 2007;13(3):376-85.
2006: Jesus Lovera; Bridget Bagert; Kyle H Smoot; Katherine Wild; Rachel Frank; Kristin Bogardus; Barry S Oken; Ruth H Whitham; Dennis N Bourdette
Correlations of Perceived Deficits Questionnaire of Multiple Sclerosis Quality of Life Inventory with Beck Depression Inventory and neuropsychological tests.
Journal of rehabilitation research and development 2006;43(1):73-82.
2006: Aaron Turner; Christine Martin; Rhonda M Williams; Kelly Goudreau; James D Bowen; Michael Hatzakis; Ruth H Whitham; Dennis N Bourdette; Lynne Walker; Jodie K Haselkorn
Exploring educational needs of multiple sclerosis care providers: Results of a care-provider survey.
Journal of rehabilitation research and development 2006;43(1):25-34.
2005: Dennis N Bourdette; E Edmonds; Craig H Smith; J D Bowen; C R G Guttmann; Z P Nagy; J Simon; Ruth H Whitham; Jesus Lovera; Vijayshree Yadav; Michele K Mass; L Spencer; Nicole Culbertson; Richard Bartholomew; Georgia Theofan; J Milano; Halina Offner; Arthur Vandenbark
A highly immunogenic trivalent T cell receptor peptide vaccine for multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) 2005;11(5):552-61.
2004: Abigail C Buenafe; Laura Tsaknaridis; Leslie Spencer; Kevin S Hicks; Rachel H McMahan; Lisa Watson; Nicole Culbertson; Dorian LaTocha; Keith Wegmann; Tom Finn; Richard Bartholomew; Gregory G Burrows; Ruth H Whitham; Dennis N Bourdette; Richard Jones; Halina Offner; Yuan K Chou; Arthur Vandenbark
Specificity of regulatory CD4+CD25+ T cells for self-T cell receptor determinants.
Journal of neuroscience research 2004;76(1):129-40.
2003: Laura Tsaknaridis; Leslie Spencer; Nicole Culbertson; Kevin Hicks; Dorian LaTocha; Yuan K Chou; Ruth H Whitham; Antony C (Tony) Bakke; Richard Jones; Halina Offner; Dennis N Bourdette; Arthur Vandenbark
Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity.
Journal of neuroscience research 2003;74(2):296-308.
2001: Richard A Rudick; Donald Goodkin; Lawrence D Jacobs; Diane L Cookfair; Robert M Herndon; John R Richert; AM Salazar; Jill Fischer; CV Granger; Jack H Simon; J J Alam; Nancy Simonian; MK Campion; DM Bartoszak; Dennis N Bourdette; J Braiman; Carol Brownscheidle; Michael E Coats; Stanley L Cohan; DS Dougherty; R Philip Kinkel; Michele K Mass; Frederick Munschauer; Roger Priore; P M Pullicino; B J Scherokman; B Weistock-Guttman; Ruth H Whitham
Impact of interferon beta-1a on neurologic disability in relapsing multiple sclerosis. 1997.
Neurology 2001;57(12 Suppl 5):S25-30.
2001: Arthur Vandenbark; Tom Finn; D Barnes; Nicole Culbertson; Yuan K Chou; K Hicks; Antony C (Tony) Bakke; Michele K Mass; Ruth H Whitham; Halina Offner; Dennis N Bourdette
Diminished frequency of interleukin-10-secreting, T-cell receptor peptide-reactive T cells in multiple sclerosis patients might allow expansion of activated memory T cells bearing the cognate BV gene.
Journal of neuroscience research 2001;66(2):171-6.
2001: Arthur Vandenbark; E Morgan; Richard Bartholomew; Dennis N Bourdette; Ruth H Whitham; D Carlo; D Gold; G Hashim; Halina Offner
TCR peptide therapy in human autoimmune diseases.
Neurochemical research 2001;26(6):713-30.
2000: Arthur Vandenbark; D Barnes; Tom Finn; Dennis N Bourdette; Ruth H Whitham; I Robey; J Kaleeba; Bruce F Bebo; S D Miller; Halina Offner; Yuan K Chou
Differential susceptibility of human T(h)1 versus T(h) 2 cells to induction of anergy and apoptosis by ECDI/antigen-coupled antigen-presenting cells.
International immunology 2000;12(1):57-66.
1999: Yuan K Chou; Dennis N Bourdette; D Barnes; Tom Finn; S Murray; L Unsicker; I Robey; Ruth H Whitham; Abigail C Buenafe; M Allegretta; Halina Offner; Arthur Vandenbark
IL-7 enhances Ag-specific human T cell response by increasing expression of IL-2R alpha and gamma chains.
Journal of neuroimmunology 1999;96(1):101-11.
1999: Andrew D Weinberg; K W Wegmann; C Funatake; Ruth H Whitham
Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1818-26.
1999: Richard A Rudick; Diane L Cookfair; Nancy Simonian; Richard M Ransohoff; John R Richert; Lawrence D Jacobs; Robert M Herndon; AM Salazar; Jill Fischer; CV Granger; Donald Goodkin; Jack H Simon; DM Bartoszak; Dennis N Bourdette; J Braiman; Carol Brownscheidle; Michael E Coats; Stanley L Cohan; DS Dougherty; R Philip Kinkel; Michele K Mass; F E Munchsauer; K O'Reilly; Roger Priore; Ruth H Whitham
Cerebrospinal fluid abnormalities in a phase III trial of Avonex (IFNbeta-1a) for relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group.
Journal of neuroimmunology 1999;93(1-2):8-14.
1998: Donald Goodkin; Roger Priore; Karl E Wende; MK Campion; Dennis N Bourdette; Robert M Herndon; Jill Fischer; Lawrence D Jacobs; Diane L Cookfair; Richard A Rudick; John R Richert; A M Salazar; CV Granger; Jack H Simon; J J Alam; DM Bartoszak; J Braiman; Carol Brownscheidle; Michael E Coats; Stanley L Cohan; DS Dougherty; R Philip Kinkel; Michele K Mass; Frederick Munschauer; Ruth H Whitham
Comparing the ability of various compositive outcomes to discriminate treatment effects in MS clinical trials. The Multiple Sclerosis Collaborative Research Group (MSCRG).
Multiple sclerosis (Houndmills, Basingstoke, England) 1998;4(6):480-6.
1998: Dennis N Bourdette; Yuan K Chou; Ruth H Whitham; J Buckner; H J Kwon; Gerald Nepom; Abigail C Buenafe; S A Cooper; M Allegretta; G A Hashim; Halina Offner; Arthur Vandenbark
Immunity to T cell receptor peptides in multiple sclerosis. III. Preferential immunogenicity of complementarity-determining region 2 peptides from disease-associated T cell receptor BV genes.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(2):1034-44.
1998: Arthur Vandenbark; Yuan K Chou; Ruth H Whitham; Dennis N Bourdette; Halina Offner
Effects of vaccination with T cell receptor peptides: epitope switching to a possible disease-protective determinant of myelin basic protein that is cross-reactive with a TCR BV peptide.
Immunology and cell biology 1998;76(1):83-90.
1998: Jack H Simon; Lawrence D Jacobs; MK Campion; Karl E Wende; Nancy Simonian; Diane L Cookfair; Richard A Rudick; Robert M Herndon; John R Richert; AM Salazar; J J Alam; Jill Fischer; Donald Goodkin; CV Granger; M Lajaunie; AL Martens-Davidson; M Meyer; Jeanelle Sheeder; K Choi; Ann L Scherzinger; DM Bartoszak; Dennis N Bourdette; J Braiman; Carol Brownscheidle; Ruth H Whitham
Magnetic resonance studies of intramuscular interferon beta-1a for relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group.
Annals of neurology 1998;43(1):79-87.
1997: Richard A Rudick; Donald Goodkin; Lawrence D Jacobs; Diane L Cookfair; Robert M Herndon; John R Richert; AM Salazar; Jill Fischer; CV Granger; Jack H Simon; J J Alam; Nancy Simonian; MK Campion; DM Bartoszak; Dennis N Bourdette; J Braiman; Carol Brownscheidle; Michael E Coats; Stanley L Cohan; DS Dougherty; R Philip Kinkel; Michele K Mass; Frederick Munschauer; Roger Priore; Ruth H Whitham
Impact of interferon beta-1a on neurologic disability in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG).
Neurology 1997;49(2):358-63.
1997: Patricia W Nance; William A Sheremata; S G Lynch; T Vollmer; S Hudson; G S Francis; P O'Connor; Jeffrey A Cohen; R T Schapiro; Ruth H Whitham; Michele K Mass; J W Lindsey; K Shellenberger
Relationship of the antispasticity effect of tizanidine to plasma concentration in patients with multiple sclerosis.
Archives of neurology 1997;54(6):731-6.
1996: Arthur Vandenbark; Yuan K Chou; Ruth H Whitham; Michele K Mass; Abigail C Buenafe; D Liefeld; D Kavanagh; S Cooper; G A Hashim; Halina Offner
Treatment of multiple sclerosis with T-cell receptor peptides: results of a double-blind pilot trial.
Nature medicine 1996;2(10):1109-15.
1996: Yuan K Chou; A D Weinberg; Abigail C Buenafe; Dennis N Bourdette; Ruth H Whitham; J A Kaleeba; I Robey; D G Kavanagh; Halina Offner; Arthur Vandenbark
MHC-restriction, cytokine profile, and immunoregulatory effects of human T cells specific for TCR V beta CDR2 peptides: comparison with myelin basic protein-specific T cells.
Journal of neuroscience research 1996;45(6):838-51.
1996: Ruth H Whitham; D Wingett; J Wineman; Michele K Mass; K Wegmann; Arthur Vandenbark; Halina Offner
Treatment of relapsing autoimmune encephalomyelitis with T cell receptor V beta-specific antibodies when proteolipid protein is the autoantigen.
Journal of neuroscience research 1996;45(2):104-16.
1996: Lawrence D Jacobs; Diane L Cookfair; Richard A Rudick; Robert M Herndon; John R Richert; AM Salazar; Jill Fischer; Donald Goodkin; C V Granger; Jack H Simon; J J Alam; DM Bartoszak; Dennis N Bourdette; J Braiman; Carol Brownscheidle; Michael E Coats; Stanley L Cohan; DS Dougherty; R Philip Kinkel; Michele K Mass; Frederick Munschauer; Roger Priore; PM Pullicino; B J Scherokman; Ruth H Whitham
Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG)
Annals of neurology 1996;39(3):285-94.
1995: W M Landau; J R Daube; M J Aminoff; Robin Brey; B R Brooks; R K Deuel; A M Galaburda; J A Porter; R B Rosenbaum; Ruth H Whitham
Neuroreality. I. Dedicated demolition of the decade of the brain:the genuine threat to neurologic research from the animal radical right American Academy of Neurology Animal Studies Subcommitte.
Journal of child neurology 1995;10(5):343-5.
1995: W M Landau; J R Daube; M J Aminoff; Robin Brey; B R Brooks; R K Deuel; A M Galaburda; J A Porter; R B Rosenbaum; Ruth H Whitham
Neuroreality I. Dedicated demolition of the Decade of the Brain: the genuine threat to neurologic research from the animal radical right. The American Academy of Neurology Animal Studies Subcommittee.
Neurology 1995;45(4):609-10.
1995: Richard Jones; Ruth H Whitham; T Sullivan; Michele K Mass; Dennis N Bourdette
Encephalitogenic T lymphocytes develop from SJL/J hematopoietic cells transplanted into severe combined immunodeficient (SCID) mice.
Journal of neuroimmunology 1995;57(1-2):155-64.
1994: Yuan K Chou; W J Morrison; A D Weinberg; R Dedrick; Ruth H Whitham; Dennis N Bourdette; G Hashim; Halina Offner; Arthur Vandenbark
Immunity to TCR peptides in multiple sclerosis. II. T cell recognition of V beta 5.2 and V beta 6.1 CDR2 peptides.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2520-9.
1994: Dennis N Bourdette; Ruth H Whitham; Yuan K Chou; W J Morrison; J Atherton; C Kenny; D Liefeld; G A Hashim; Halina Offner; Arthur Vandenbark
Immunity to TCR peptides in multiple sclerosis. I. Successful immunization of patients with synthetic V beta 5.2 and V beta 6.1 CDR2 peptides.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2510-9.
1994: Yuan K Chou; Abigail C Buenafe; R Dedrick; W J Morrison; Dennis N Bourdette; Ruth H Whitham; J Atherton; J Lane; E Spoor; G A Hashim
T cell receptor V beta gene usage in the recognition of myelin basic protein by cerebrospinal fluid- and blood-derived T cells from patients with multiple sclerosis.
Journal of neuroscience research 1994;37(2):169-81.
1994: Yuan K Chou; Richard Jones; Dennis N Bourdette; Ruth H Whitham; G Hashim; J Atherton; Halina Offner; Arthur Vandenbark
Human myelin basic protein (MBP) epitopes recognized by mouse MBP-selected T cell lines from multiple sclerosis patients.
Journal of neuroimmunology 1994;49(1-2):45-50.
1993: Arthur Vandenbark; Dennis N Bourdette; Ruth H Whitham; Yuan K Chou; G A Hashim; Halina Offner
Episodic changes in T-cell frequencies to myelin basic protein in patients with multiple sclerosis.
Neurology 1993;43(11):2416-7.
1993: Ruth H Whitham; B L Kotzin; Abigail C Buenafe; A D Weinberg; Richard Jones; G A Hashim; C M Hoy; Arthur Vandenbark; Halina Offner
Treatment of relapsing experimental autoimmune encephalomyelitis with T cell receptor peptides.
Journal of neuroscience research 1993;35(2):115-28.
1993: Richard Jones; Dennis N Bourdette; Ruth H Whitham; Halina Offner; Arthur Vandenbark
Induction of experimental autoimmune encephalomyelitis in severe combined immunodeficient mice reconstituted with allogeneic or xenogeneic hematopoietic cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(10):4620-9.
1993: K Satyanarayana; Yuan K Chou; Dennis N Bourdette; Ruth H Whitham; G A Hashim; Halina Offner; Arthur Vandenbark
Epitope specificity and V gene expression of cerebrospinal fluid T cells specific for intact versus cryptic epitopes of myelin basic protein.
Journal of neuroimmunology 1993;44(1):57-67.
1993: Arthur Vandenbark; Dennis N Bourdette; Ruth H Whitham; Yuan K Chou; G A Hashim; Halina Offner
T-cell receptor peptide therapy in EAE and MS.
Clinical and experimental rheumatology 1993;11 Suppl 8():S51-3.
1992: Yuan K Chou; Dennis N Bourdette; Halina Offner; Ruth H Whitham; R Y Wang; G A Hashim; Arthur Vandenbark
Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis.
Journal of neuroimmunology 1992;38(1-2):105-13.
1992: Donald Goodkin; Diane L Cookfair; Karl E Wende; Dennis N Bourdette; P Pullicino; B Scherokman; Ruth H Whitham
Inter- and intrarater scoring agreement using grades 1.0 to 3.5 of the Kurtzke Expanded Disability Status Scale (EDSS). Multiple Sclerosis Collaborative Research Group.
Neurology 1992;42(4):859-63.
1992: Arthur Vandenbark; Yuan K Chou; Dennis N Bourdette; Ruth H Whitham; G A Hashim; Halina Offner
T cell receptor peptide therapy for autoimmune disease.
Journal of autoimmunity 1992;5 Suppl A():83-92.
1992: A D Weinberg; Ruth H Whitham; S L Swain; W J Morrison; G Wyrick; C Hoy; Arthur Vandenbark; Halina Offner
Transforming growth factor-beta enhances the in vivo effector function and memory phenotype of antigen-specific T helper cells in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):2109-17.
1991: Ruth H Whitham; Richard Jones; G A Hashim; C M Hoy; R Y Wang; Arthur Vandenbark; Halina Offner
Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL x PL)F1 mice.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(11):3803-8.
1991: Yuan K Chou; Paula Maria Henderikx; M Vainiene; Ruth H Whitham; Dennis N Bourdette; C H Chou; G Hashim; Halina Offner; Arthur Vandenbark
Specificity of human T cell clones reactive to immunodominant epitopes of myelin basic protein.
Journal of neuroscience research 1991;28(2):280-90.
1991: Ruth H Whitham; Dennis N Bourdette; G A Hashim; R M Herndon; R C Ilg; Arthur Vandenbark; Halina Offner
Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(1):101-7.
1990: Ruth H Whitham; Arthur Vandenbark; Dennis N Bourdette; Yuan K Chou; Halina Offner
Suppressor cell regulation of encephalitogenic T cell lines: generation of suppressor macrophages with cyclosporin A and myelin basic protein.
Cellular immunology 1990;126(2):290-303.
1989: Yuan K Chou; M Vainiene; Ruth H Whitham; Dennis N Bourdette; C H Chou; G Hashim; Halina Offner; Arthur Vandenbark
Response of human T lymphocyte lines to myelin basic protein: association of dominant epitopes with HLA class II restriction molecules.
Journal of neuroscience research 1989;23(2):207-16.
1989: Arthur Vandenbark; Yuan K Chou; Dennis N Bourdette; Ruth H Whitham; J Chilgren; C H Chou; G Konat; G Hashim; M Vainiene; Halina Offner
Human T lymphocyte response to myelin basic protein: selection of T lymphocyte lines from MBP-responsive donors.
Journal of neuroscience research 1989;23(1):21-30.
1989: Dennis N Bourdette; Arthur Vandenbark; G Hashim; Ruth H Whitham; Halina Offner
T cell lines selected with synthetic peptides are highly encephalitogenic in SJL/J mice.
Journal of neuroimmunology 1989;22(3):255-60.
1988: Ruth H Whitham; G Nilaver; Dennis N Bourdette; F J Seil
Serum anti-myelin antibodies in chronic relapsing experimental allergic encephalomyelitis.
Journal of neuroimmunology 1988;18(2):155-70.
1988: Dennis N Bourdette; Arthur Vandenbark; C Meshul; Ruth H Whitham; Halina Offner
Basic protein-specific T-cell lines that induce experimental autoimmune encephalomyelitis in SJL/J mice: comparison with Lewis rat lines.
Cellular immunology 1988;112(2):351-63.
1988: Ruth H Whitham; Dennis N Bourdette; Halina Offner; C K Meshul; Arthur Vandenbark
Suppressor cell regulation of chronic relapsing experimental allergic encephalomyelitis.
Annals of the New York Academy of Sciences 1988;540():537-9.
1985: Ruth H Whitham; Robin Brey
Neuromyelitis optica: two new cases and review of the literature.
Journal of clinical neuro-ophthalmology 1985;5(4):263-9.
1977: J E Berkelhamer; Ruth H Whitham; J J North
Distorted conceptions of infant nutrition among urban mothers. An illustration of the great need for well-baby health supervision.
Clinical pediatrics 1977;16(11):986-7.