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Paul Whiting

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Rosa L Fradley; Martin R Guscott; Sharlene Bull; David J Hallett; Simon C Goodacre; Keith A Wafford; Elizabeth M Garrett; Richard J Newman; Gillian F O'Meara; Paul J Whiting; Thomas W Rosahl; Gerard R Dawson; David S Reynolds; John R Atack
Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.
L Miguel Camargo; V Collura; Jean-Christophe Rain; K Mizuguchi; Henning Hermjakob; Samuel Kerrien; Timothy P Bonnert; Paul J Whiting; Nicholas J Brandon
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.
Thomas W Rosahl; Peter B Wingrove; Verity Hunt; Rosa L Fradley; Jason M K Lawrence; Robert P Heavens; Patrick Treacey; Marcelo Usala; Alison Macaulay; Timothy P Bonnert; Paul J Whiting; Keith A Wafford
A genetically modified mouse model probing the selective action of ifenprodil at the N-methyl-D-aspartate type 2B receptor.

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2007: Rosa L Fradley; Martin R Guscott; Sharlene Bull; David J Hallett; Simon C Goodacre; Keith A Wafford; Elizabeth M Garrett; Richard J Newman; Gillian F O'Meara; Paul J Whiting; Thomas W Rosahl; Gerard R Dawson; David S Reynolds; John R Atack
Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.
Journal of psychopharmacology (Oxford, England) 2007;21(4):384-91.
2007: L Miguel Camargo; V Collura; Jean-Christophe Rain; K Mizuguchi; Henning Hermjakob; Samuel Kerrien; Timothy P Bonnert; Paul J Whiting; Nicholas J Brandon
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.
Molecular psychiatry 2007;12(1):74-86.
2006: Thomas W Rosahl; Peter B Wingrove; Verity Hunt; Rosa L Fradley; Jason M K Lawrence; Robert P Heavens; Patrick Treacey; Marcelo Usala; Alison Macaulay; Timothy P Bonnert; Paul J Whiting; Keith A Wafford
A genetically modified mouse model probing the selective action of ifenprodil at the N-methyl-D-aspartate type 2B receptor.
Molecular and cellular neurosciences 2006;33(1):47-56.
2006: Paul J Whiting
GABA-A receptors: a viable target for novel anxiolytics?
Current opinion in pharmacology 2006;6(1):24-9.
2005: J Kirsty Millar; Ben S Pickard; Shaun Mackie; Rachel James; Sheila Christie; Sebastienne R Buchanan; M Pat Malloy; Jennifer E Chubb; Elaine Huston; George S Baillie; Pippa A Thomson; Elaine V Hill; Nicholas J Brandon; Jean-Christophe Rain; L Miguel Camargo; Paul J Whiting; Miles D Houslay; D H R Blackwood; Walter J Muir; David J Porteous
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
Science (New York, N.Y.) 2005;310(5751):1187-91.
2005: Rebecca Dias; Wayne F A Sheppard; Rosa L Fradley; Elizabeth M Garrett; Joanna L Stanley; Spencer J Tye; Simon C Goodacre; Rachael Lincoln; Susan M Cook; Rachel Conley; David J Hallett; Alexander C Humphries; Sally-Anne Thompson; Keith A Wafford; Leslie J Street; José L Castro; Paul J Whiting; Thomas W Rosahl; John R Atack; Ruth M McKernan; Gerard R Dawson; David S Reynolds
Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(46):10682-8.
2005: Nicholas J Brandon; Irina Schurov; L Miguel Camargo; EJ Handford; B Duran-Jimeniz; P Hunt; J Kirsty Millar; David J Porteous; Mark S Shearman; Paul J Whiting
Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site.
Molecular and cellular neurosciences 2005;28(4):613-24.
2005: Mirian A F Hayashi; Fernanda C V Portaro; Marta F Bastos; Juliano R Guerreiro; Vitor Oliveira; Silvia S Gorrão; Denise V Tambourgi; Osvaldo Augusto Sant'Anna; Paul J Whiting; L Miguel Camargo; Katsuhiro Konno; Nicholas J Brandon; Antonio C M Camargo
Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3828-33.
2005: Martin R Guscott; Linda J Bristow; Karen L Hadingham; Thomas W Rosahl; Margaret S Beer; Josephine A Stanton; Frances A Bromidge; Andrew P Owens; Ian T Huscroft; Janice Myers; Nadia M J Rupniak; Smita Patel; Paul J Whiting; Peter H Hutson; Kevin C F Fone; S M Biello; Janusz J Kulagowski; George McAllister
Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression.
Neuropharmacology 2005;48(4):492-502.
2004: Irina Schurov; EJ Handford; Nicholas J Brandon; Paul J Whiting
Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment.
Molecular psychiatry 2004;9(12):1100-10.
2004: Stephen L Boehm; Igor Ponomarev; Andrew W Jennings; Paul J Whiting; Thomas W Rosahl; Elisabeth M Garrett; Yuri A Blednov; R Adron Harris
gamma-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions.
Biochemical pharmacology 2004;68(8):1581-602.
2004: Sally-Anne Thompson; L Wheat; N A Brown; Peter B Wingrove; Gopalan V Pillai; Paul J Whiting; Charles H Adkins; C H Woodward; A J Smith; Peter B Simpson; Ian Collins; Keith A Wafford
Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors.
British journal of pharmacology 2004;142(1):97-106.
2004: Nicholas J Brandon; EJ Handford; Irina Schurov; Jean-Christophe Rain; M Pelling; B Duran-Jimeniz; L Miguel Camargo; K R Oliver; Dirk Beher; Mark S Shearman; Paul J Whiting
Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.
Molecular and cellular neurosciences 2004;25(1):42-55.
2003: Marcello Usala; Sally-Anne Thompson; Paul J Whiting; Keith A Wafford
Activity of chlormethiazole at human recombinant GABA(A) and NMDA receptors.
British journal of pharmacology 2003;140(6):1045-50.
2003: David S Reynolds; Thomas W Rosahl; Jennifer Cirone; Gillian F O'Meara; Alison Haythornthwaite; Richard J Newman; Janice Myers; Cyrille Sur; Owain Howell; A Richard Rutter; John R Atack; Alison Macaulay; Karen L Hadingham; Peter H Hutson; Delia Belelli; Jeremy J Lambert; Gerard R Dawson; Ruth M McKernan; Paul J Whiting; Keith A Wafford
Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(24):8608-17.
2003: Paul J Whiting
The GABAA receptor gene family: new opportunities for drug development.
Current opinion in drug discovery & development 2003;6(5):648-57.
2003: Paul J Whiting
GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?
Drug discovery today 2003;8(10):445-50.
2003: David S Reynolds; Gillian F O'Meara; Richard J Newman; Frances A Bromidge; John R Atack; Paul J Whiting; Thomas W Rosahl; Gerard R Dawson
GABA(A) alpha 1 subunit knock-out mice do not show a hyperlocomotor response following amphetamine or cocaine treatment.
Neuropharmacology 2003;44(2):190-8.
2003: Yuri A Blednov; Sangwook Jung; Herminia Alva; D Wallace; Thomas W Rosahl; Paul J Whiting; R Adron Harris
Deletion of the alpha1 or beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs.
The Journal of pharmacology and experimental therapeutics 2003;304(1):30-6.
2002: Sally-Anne Thompson; Timothy P Bonnert; E Cagetti; Paul J Whiting; Keith A Wafford
Overexpression of the GABA(A) receptor epsilon subunit results in insensitivity to anaesthetics.
Neuropharmacology 2002;43(4):662-8.
2002: N Brown; Julie Kerby; Timothy P Bonnert; Paul J Whiting; Keith A Wafford
Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors.
British journal of pharmacology 2002;136(7):965-74.
2002: Neil Collinson; Frederick M Kuenzi; Wolfgang Jarolimek; Karen A Maubach; Rosa Cothliff; Cyrille Sur; Alison Smith; Otu Franklin; Owain Howell; John R Atack; Ruth M McKernan; Guy R Seabrook; Gerard R Dawson; Paul J Whiting; Thomas W Rosahl
Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(13):5572-80.
2002: Sally-Anne Thompson; Peter B Wingrove; Linda Connelly; Paul J Whiting; Keith A Wafford
Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors.
Molecular pharmacology 2002;61(4):861-9.
2002: Peter B Wingrove; Patrick Safo; Lola Wheat; Sally-Anne Thompson; Keith A Wafford; Paul J Whiting
Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors.
European journal of pharmacology 2002;437(1-2):31-9.
2001: C E Adkins; Gopalan V Pillai; Julie Kerby; Timothy P Bonnert; Christine Haldon; Ruth M McKernan; J E Gonzalez; K Oades; Paul J Whiting; Peter B Simpson
alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential.
The Journal of biological chemistry 2001;276(42):38934-9.
2001: Cyrille Sur; Keith A Wafford; David S Reynolds; Karen L Hadingham; Frances A Bromidge; Alison Macaulay; Neil Collinson; Gillian F O'Meara; Owain Howell; Robert Newman; Janice Myers; John R Atack; Gerard R Dawson; Ruth M McKernan; Paul J Whiting; Thomas W Rosahl
Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(10):3409-18.
2001: A Paterson; Paul J Whiting; J A Gray; J Flint; Gerard R Dawson
Lack of consistent behavioural effects of Maudsley reactive and non-reactive rats in a number of animal tests of anxiety and activity.
Psychopharmacology 2001;154(4):336-42.
2001: M A Casula; Frances A Bromidge; Gopalan V Pillai; Peter B Wingrove; Karine Martin; Karen A Maubach; Guy R Seabrook; Paul J Whiting; Karen L Hadingham
Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor.
Journal of neurochemistry 2001;77(2):445-51.
2000: Ruth M McKernan; Thomas W Rosahl; David S Reynolds; Cyrille Sur; Keith A Wafford; John R Atack; SJ Farrar; Janice Myers; G Cook; Pushpinder Ferris; L Garrett; Linda J Bristow; George Marshall; Alison Macaulay; Nicola Brown; Owain Howell; Kevin W Moore; Robert W Carling; Leslie J Street; José L Castro; C I Ragan; Gerard R Dawson; Paul J Whiting
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.
Nature neuroscience 2000;3(6):587-92.
1999: Timothy P Bonnert; Ruth M McKernan; SJ Farrar; B Le Bourdellès; Robert P Heavens; DW Smith; Louise Hewson; MR Rigby; DJ Sirinathsinghji; Nicola Brown; Keith A Wafford; Paul J Whiting
theta, a novel gamma-aminobutyric acid type A receptor subunit.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9891-6.
1999: Sally-Anne Thompson; M Z Smith; Peter B Wingrove; Paul J Whiting; Keith A Wafford
Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation.
British journal of pharmacology 1999;127(6):1349-58.
1999: Cyrille Sur; SJ Farrar; Julie Kerby; Paul J Whiting; John R Atack; Ruth M McKernan
Preferential coassembly of alpha4 and delta subunits of the gamma-aminobutyric acidA receptor in rat thalamus.
Molecular pharmacology 1999;56(1):110-5.
1999: Sally-Anne Thompson; S A Arden; George Marshall; Peter B Wingrove; Paul J Whiting; Keith A Wafford
Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide.
Molecular pharmacology 1999;55(6):993-9.
1999: Paul J Whiting; Timothy P Bonnert; Ruth M McKernan; SJ Farrar; B Le Bourdellès; Robert P Heavens; DW Smith; Louise Hewson; MR Rigby; DJ Sirinathsinghji; Sally-Anne Thompson; Keith A Wafford
Molecular and functional diversity of the expanding GABA-A receptor gene family.
Annals of the New York Academy of Sciences 1999;868():645-53.
1999: SJ Farrar; Paul J Whiting; Timothy P Bonnert; Ruth M McKernan
Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transfer.
The Journal of biological chemistry 1999;274(15):10100-4.
1999: S Sandhu; S Grimwood; Russell Mortishire-Smith; Paul J Whiting; B Le Bourdellès
Delineation of the structural determinants of the N-methyl-D-aspartate receptor glycine binding site.
Journal of neurochemistry 1999;72(4):1694-8.
1998: Sally-Anne Thompson; Timothy P Bonnert; Paul J Whiting; Keith A Wafford
Functional characteristics of recombinant human GABA(A) receptors containing the epsilon-subunit.
Toxicology letters 1998;100-101():233-8.
1998: R A Jeffrey McIlhinney; B Le Bourdellès; E Molnár; N Tricaud; Peter Streit; Paul J Whiting
Assembly intracellular targeting and cell surface expression of the human N-methyl-D-aspartate receptor subunits NR1a and NR2A in transfected cells.
Neuropharmacology 1998;37(10-11):1355-67.
1998: R Adron Harris; C F Valenzuela; SJ Brozowski; L Chuang; Karen L Hadingham; Paul J Whiting
Adaptation of gamma-aminobutyric acid type A receptors to alcohol exposure: studies with stably transfected cells.
The Journal of pharmacology and experimental therapeutics 1998;284(1):180-8.
1997: Peter B Wingrove; Sally-Anne Thompson; Keith A Wafford; Paul J Whiting
Key amino acids in the gamma subunit of the gamma-aminobutyric acidA receptor that determine ligand binding and modulation at the benzodiazepine site.
Molecular pharmacology 1997;52(5):874-81.
1997: Delia Belelli; Jeremy J Lambert; John A Peters; Keith A Wafford; Paul J Whiting
The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):11031-6.
1997: Paul J Whiting; George McAllister; Timothy P Bonnert; Robert P Heavens; MR Rigby; DJ Sirinathsinghji; G Marshall; Sally-Anne Thompson; Keith A Wafford
The use of expressed sequence tag databases to identify novel human gamma-aminobutyric acid type receptor genes.
Biochemical Society transactions 1997;25(3):817-9.
1997: Matthew D Krasowski; S M O'Shea; CE Rick; Paul J Whiting; Karen L Hadingham; C Czajkowski; Neil L Harrison
Alpha subunit isoform influences GABA(A) receptor modulation by propofol.
Neuropharmacology 1997;36(7):941-9.
1997: Paul J Whiting; George McAllister; D Vassilatis; Timothy P Bonnert; Robert P Heavens; DW Smith; Louise Hewson; Ruth O'Donnell; MR Rigby; DJ Sirinathsinghji; G Marshall; Sally-Anne Thompson; Keith A Wafford; D Vasilatis
Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties [corrected; erratum to be published].
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(13):5027-37.
1997: R Adron Harris; S J Mihic; SJ Brozowski; Karen L Hadingham; Paul J Whiting
Ethanol, flunitrazepam, and pentobarbital modulation of GABAA receptors expressed in mammalian cells and Xenopus oocytes.
Alcoholism, clinical and experimental research 1997;21(3):444-51.
1996: Keith A Wafford; Sally-Anne Thompson; D Thomas; James M Sikela; A S Wilcox; Paul J Whiting
Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit.
Molecular pharmacology 1996;50(3):670-8.
1996: C Fernando Valenzuela; Z Xiong; J F MacDonald; Jeff Weiner; C J Frazier; Thomas V Dunwiddie; Andrius Kazlauskas; Paul J Whiting; R Adron Harris
Platelet-derived growth factor induces a long-term inhibition of N-methyl-D-aspartate receptor function.
The Journal of biological chemistry 1996;271(27):16151-9.
1996: Michael Rigby; B Le Bourdellès; Robert P Heavens; S Kelly; D Smith; A Butler; R Hammans; R Hills; J H Xuereb; Raymond G Hill; Paul J Whiting; DJ Sirinathsinghji
The messenger RNAs for the N-methyl-D-aspartate receptor subunits show region-specific expression of different subunit composition in the human brain.
Neuroscience 1996;73(2):429-47.
1996: Sarah Grimwood; B Le Bourdellès; John R Atack; C Barton; W Cockett; S M Cook; E Gilbert; Peter H Hutson; Ruth M McKernan; J Myers; C Ian Ragan; Peter B Wingrove; Paul J Whiting
Generation and characterisation of stable cell lines expressing recombinant human N-methyl-D-aspartate receptor subtypes.
Journal of neurochemistry 1996;66(6):2239-47.
1996: V J Whatley; SJ Brozowski; Karen L Hadingham; Paul J Whiting; R Adron Harris
Microtubule depolymerization inhibits ethanol-induced enhancement of GABAA responses in stably transfected cells.
Journal of neurochemistry 1996;66(3):1318-21.
1996: R A Jeffrey McIlhinney; E Molnár; J R Atack; Paul J Whiting
Cell surface expression of the human N-methyl-D-aspartate receptor subunit 1a requires the co-expression of the NR2A subunit in transfected cells.
Neuroscience 1996;70(4):989-97.
1996: Sally-Anne Thompson; Paul J Whiting; Keith A Wafford
Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination.
British journal of pharmacology 1996;117(3):521-527.
1996: Karen L Hadingham; E M Garrett; Keith A Wafford; C Bain; Robert P Heavens; DJ Sirinathsinghji; Paul J Whiting
Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors.
Molecular pharmacology 1996;49(2):253-9.
1996: Martin Davies; Ian L Martin; Alan Bateson; Karen L Hadingham; Paul J Whiting; Susan M J Dunn
Identification of domains in human recombinant GABAA receptors that are photoaffinity labelled by [3H]flunitrazepam and [3H]Ro15-4513.
Neuropharmacology 1996;35(9-10):1199-208.
1995: A Stevenson; Peter B Wingrove; Paul J Whiting; Keith A Wafford
beta-Carboline gamma-aminobutyric acidA receptor inverse agonists modulate gamma-aminobutyric acid via the loreclezole binding site as well as the benzodiazepine site.
Molecular pharmacology 1995;48(6):965-9.
1995: Karen L Hadingham; Keith A Wafford; S A Thompson; K J Palmer; Paul J Whiting
Expression and pharmacology of human GABAA receptors containing gamma 3 subunits.
European journal of pharmacology 1995;291(3):301-9.
1995: T Priestley; P Laughton; J Myers; B Le Bourdellés; J Kerby; Paul J Whiting
Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells.
Molecular pharmacology 1995;48(5):841-8.
1995: Ronald L. Klein; M P Mascia; Paul J Whiting; R Adron Harris
GABAA receptor function and binding in stably transfected cells: chronic ethanol treatment.
Alcoholism, clinical and experimental research 1995;19(5):1338-44.
1995: Ronald L. Klein; M P Mascia; P C Harkness; Karen L Hadingham; Paul J Whiting; R Adron Harris
Regulation of allosteric coupling and function of stably expressed gamma-aminobutyric acid (GABA)A receptors by chronic treatment with GABAA and benzodiazepine agonists.
The Journal of pharmacology and experimental therapeutics 1995;274(3):1484-92.
1995: Kathleen Quirk; Paul J Whiting; C Ian Ragan; Ruth M McKernan
Characterisation of delta-subunit containing GABAA receptors from rat brain.
European journal of pharmacology 1995;290(3):175-81.
1995: Enrico Sanna; M P Mascia; Ronald L. Klein; Paul J Whiting; G Biggio; R Adron Harris
Actions of the general anesthetic propofol on recombinant human GABAA receptors: influence of receptor subunits.
The Journal of pharmacology and experimental therapeutics 1995;274(1):353-60.
1995: Keith A Wafford; M Kathoria; C J Bain; G Marshall; B Le Bourdellès; J A Kemp; Paul J Whiting
Identification of amino acids in the N-methyl-D-aspartate receptor NR1 subunit that contribute to the glycine binding site.
Molecular pharmacology 1995;47(2):374-80.
1995: Sarah Grimwood; B Le Bourdellès; Paul J Whiting
Recombinant human NMDA homomeric NR1 receptors expressed in mammalian cells form a high-affinity glycine antagonist binding site.
Journal of neurochemistry 1995;64(2):525-30.
1995: R Adron Harris; W R Proctor; S J McQuilkin; Ronald L. Klein; M P Mascia; V Whatley; Paul J Whiting; Thomas V Dunwiddie
Ethanol increases GABAA responses in cells stably transfected with receptor subunits.
Alcoholism, clinical and experimental research 1995;19(1):226-32.
1995: Ruth M McKernan; Keith A Wafford; Kathleen Quirk; Karen L Hadingham; E A Harley; C Ian Ragan; Paul J Whiting
The pharmacology of the benzodiazepine site of the GABA-A receptor is dependent on the type of gamma-subunit present.
Journal of receptor and signal transduction research 1995;15(1-4):173-83.
1995: Paul J Whiting; Ruth M McKernan; Keith A Wafford
Structure and pharmacology of vertebrate GABAA receptor subtypes.
International review of neurobiology 1995;38():95-138.
1995: S John Mihic; Enrico Sanna; Paul J Whiting; R Adron Harris
Pharmacology of recombinant GABAA receptors.
Advances in biochemical psychopharmacology 1995;48():17-40.
1994: S John Mihic; Paul J Whiting; Ronald L. Klein; Keith A Wafford; R Adron Harris
A single amino acid of the human gamma-aminobutyric acid type A receptor gamma 2 subunit determines benzodiazepine efficacy.
The Journal of biological chemistry 1994;269(52):32768-73.
1994: Ronald L. Klein; Paul J Whiting; R Adron Harris
Benzodiazepine treatment causes uncoupling of recombinant GABAA receptors expressed in stably transfected cells.
Journal of neurochemistry 1994;63(6):2349-52.
1994: Bjarke Ebert; K A Wafford; Paul J Whiting; Povl Krogsgaard-Larsen; J A Kemp
Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations.
Molecular pharmacology 1994;46(5):957-63.
1994: Ronald L. Klein; Enrico Sanna; S J McQuilkin; Paul J Whiting; R Adron Harris
Effects of 5-HT3 receptor antagonists on binding and function of mouse and human GABAA receptors.
European journal of pharmacology 1994;268(2):237-46.
1994: S John Mihic; Paul J Whiting; R Adron Harris
Anaesthetic concentrations of alcohols potentiate GABAA receptor-mediated currents: lack of subunit specificity.
European journal of pharmacology 1994;268(2):209-14.
1994: Kathleen Quirk; N P Gillard; C Ian Ragan; Paul J Whiting; Ruth M McKernan
Model of subunit composition of gamma-aminobutyric acid A receptor subtypes expressed in rat cerebellum with respect to their alpha and gamma/delta subunits.
The Journal of biological chemistry 1994;269(23):16020-8.
1994: B Le Bourdellès; Keith A Wafford; J A Kemp; G Marshall; C Bain; A S Wilcox; James M Sikela; Paul J Whiting
Cloning, functional coexpression, and pharmacological characterisation of human cDNAs encoding NMDA receptor NR1 and NR2A subunits.
Journal of neurochemistry 1994;62(6):2091-8.
1994: Kathleen Quirk; N P Gillard; C Ian Ragan; Paul J Whiting; Ruth M McKernan
gamma-Aminobutyric acid type A receptors in the rat brain can contain both gamma 2 and gamma 3 subunits, but gamma 1 does not exist in combination with another gamma subunit.
Molecular pharmacology 1994;45(6):1061-70.
1994: Peter B Wingrove; Keith A Wafford; C Bain; Paul J Whiting
The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4569-73.
1994: Keith A Wafford; C J Bain; Kathleen Quirk; Ruth M McKernan; Peter B Wingrove; Paul J Whiting; J A Kemp
A novel allosteric modulatory site on the GABAA receptor beta subunit.
Neuron 1994;12(4):775-82.
1993: Keith A Wafford; C J Bain; B Le Bourdelles; Paul J Whiting; J A Kemp
Preferential co-assembly of recombinant NMDA receptors composed of three different subunits.
Neuroreport 1993;4(12):1347-9.
1993: Keith A Wafford; C J Bain; Paul J Whiting; J A Kemp
Functional comparison of the role of gamma subunits in recombinant human gamma-aminobutyric acidA/benzodiazepine receptors.
Molecular pharmacology 1993;44(2):437-42.
1993: C Ian Ragan; Ruth M McKernan; Keith A Wafford; Paul J Whiting
gamma-Aminobutyric acid-A (GABA-A) receptor/ion channel complex.
Biochemical Society transactions 1993;21 ( Pt 3)(3):622-6.
1993: Karen L Hadingham; Peter B Wingrove; B Le Bourdelles; K J Palmer; C Ian Ragan; Paul J Whiting
Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors.
Molecular pharmacology 1993;43(6):970-5.
1993: Nancy J Leidenheimer; Paul J Whiting; R Adron Harris
Activation of calcium-phospholipid-dependent protein kinase enhances benzodiazepine and barbiturate potentiation of the GABAA receptor.
Journal of neurochemistry 1993;60(5):1972-5.
1993: K A Wafford; Paul J Whiting; J A Kemp
Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.
Molecular pharmacology 1993;43(2):240-4.
1993: K A Wafford; D Burnett; R A Harris; Paul J Whiting
GABAA receptor subunit expression and sensitivity to ethanol.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1993;2():327-30.
1992: Keith A Wafford; Paul J Whiting
Ethanol potentiation of GABAA receptors requires phosphorylation of the alternatively spliced variant of the gamma 2 subunit.
FEBS letters 1992;313(2):113-7.
1992: Karen L Hadingham; P C Harkness; Ruth M McKernan; Kathleen Quirk; B Le Bourdellès; A L Horne; J A Kemp; E A Barnard; C Ian Ragan; Paul J Whiting
Stable expression of mammalian type A gamma-aminobutyric acid receptors in mouse cells: demonstration of functional assembly of benzodiazepine-responsive sites.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6378-82.