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Jeffrey Whitsett

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Physiology

Gene Expression Regulation

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Publications

TOP 3
Edward E Morrisey; Yoh-suke Mukouyama; Lawrence S Prince; Marlene Rabinovitch; Jeff Reese; Janet Rossant; Wei Shi; Xin Sun; Zena Werb; Jeffrey A Whitsett; Steven H Abman; Xingbin Ai; Kurt H Albertine; Carol J Blaisdell; Richard D Bland; Wellington V Cardoso; Harold A Chapman; William Checkley; Jonathan A Epstein; Dorothy B Gail; Christopher R Kintner; Maya Kumar; Robert H Lane; Thomas J Mariani; Donald M McDonald; Parviz Minoo; Qing S Lin
Molecular determinants of lung development.
David Balli; Vladimir V. Kalinichenko; Alex J Masino; Xiaomeng Ren; Vladimir Ustiyan; I-Ching Wang; Jeffrey A Whitsett; Yufang Zhang; Tanya V Kalin
Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition.
Xiaomeng Ren; Tushar A Shah; John Shinn; Vladimir Ustiyan; Jeffrey A Whitsett; Yufang Zhang; Gang Chen; Tanya V Kalin; Vladimir V. Kalinichenko
FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation.

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2013: Edward E Morrisey; Yoh-suke Mukouyama; Lawrence S Prince; Marlene Rabinovitch; Jeff Reese; Janet Rossant; Wei Shi; Xin Sun; Zena Werb; Jeffrey A Whitsett; Steven H Abman; Xingbin Ai; Kurt H Albertine; Carol J Blaisdell; Richard D Bland; Wellington V Cardoso; Harold A Chapman; William Checkley; Jonathan A Epstein; Dorothy B Gail; Christopher R Kintner; Maya Kumar; Robert H Lane; Thomas J Mariani; Donald M McDonald; Parviz Minoo; Qing S Lin
Molecular determinants of lung development.
Annals of the American Thoracic Society 2013;10(2):S12-6.
2013: David Balli; Vladimir V. Kalinichenko; Alex J Masino; Xiaomeng Ren; Vladimir Ustiyan; I-Ching Wang; Jeffrey A Whitsett; Yufang Zhang; Tanya V Kalin
Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition.
The EMBO journal 2013;32(2):231-44.
2013: Xiaomeng Ren; Tushar A Shah; John Shinn; Vladimir Ustiyan; Jeffrey A Whitsett; Yufang Zhang; Gang Chen; Tanya V Kalin; Vladimir V. Kalinichenko
FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation.
Molecular and cellular biology 2013;33(2):371-86.
2012: Yutaka Maeda; Michael L Mucenski; Takeshi Nagayasu; Yoshio Naomoto; David H Tompkins; Tomoshi Tsuchiya; Lingling Du; Takuya Fukazawa; Haiping Hao; Angela R Keiser; Yan Xu; Jeffrey A Whitsett
Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung.
The Journal of clinical investigation 2012;122(12):4388-400.
2012: Jean A Tkach; Jeffrey A Whitsett; Patrick M Winter; Barret R Daniels; Randy O Giaquinto; Noah H Hillman; Machiko Ikegami; Alan H Jobe; Suhas Kallapur; Beth M Kline-Fath; Yu Li; Wolfgang Loew; Stephanie L Merhar; Ron G Pratt; Charles L Dumoulin
An MRI system for imaging neonates in the NICU: initial feasibility study.
Pediatric radiology 2012;42(11):1347-56.
2012: Vladimir Ustiyan; I-Ching Wang; Susan E Wert; Jeffrey A Whitsett; Machiko Ikegami; Tanya V Kalin; Vladimir V. Kalinichenko
Foxm1 transcription factor is critical for proliferation and differentiation of Clara cells during development of conducting airways.
Developmental biology 2012;370(2):198-212.
2012: Atsuyasu Sato; Jeffrey A Whitsett; Yan Xu; Machiko Ikegami
CCAAT/enhancer binding protein-α regulates the protease/antiprotease balance required for bronchiolar epithelium regeneration.
American journal of respiratory cell and molecular biology 2012;47(4):454-63.
2012: Brian M Varisco; Jeffrey A Whitsett; Namasivayam Ambalavanan; James Hagood
Thy-1 signals through PPARγ to promote lipofibroblast differentiation in the developing lung.
American journal of respiratory cell and molecular biology 2012;46(6):765-72.
2012: Laurent Plantier; Anthony D Postle; Susan E Wert; Valerie Besnard; Alan N Hunt; Machiko Ikegami; Yan Xu; Jeffrey A Whitsett
Activation of sterol-response element-binding proteins (SREBP) in alveolar type II cells enhances lipogenesis causing pulmonary lipotoxicity.
The Journal of biological chemistry 2012;287(13):10099-114.
2012: Yan Xu; Valerie Besnard; Leah Rae Donahue; Caleb Heffner; Machiko Ikegami; Stephen A Murray; Yanhua Wang; Susan E Wert; Jeffrey A Whitsett
Transcriptional programs controlling perinatal lung maturation.
PloS one 2012;7(8):e37046.
2011: Zvjezdana Sever-Chroneos; Jay W Tichelaar; Mitchell R White; Jeffrey A Whitsett; Jeremy Davis; Jon Matthew Florence; Kevan L Hartshorn; Lester Kobzik; Agnieszka Krupa; Anna K Kurdowska; Aditi Murthy; Zissis C Chroneos
GM-CSF modulates pulmonary resistance to influenza A infection.
Antiviral research 2011;92(2):319-28.
2011: Laurent Plantier; Susan E Wert; Bruno Crestani; Monique Dehoux; Andreas Guenther; Barbara Zweytick; Jeffrey A Whitsett
Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis.
Thorax 2011;66(8):651-7.
2011: Fang-Fang Huang; Steven Idell; Daniel R Perez; Timothy Allen; Peter F Barnes; Zissis C Chroneos; Ruben Donis; Kyri Dunussi-Joannopoulos; Yan Feng; Jeffrey A Whitsett; Homayoun Shams
GM-CSF in the lung protects against lethal influenza infection.
American journal of respiratory and critical care medicine 2011;184(2):259-68.
2011: David H Tompkins; Susan E Wert; Valerie Besnard; Michael D Bruno; Angela R Keiser; Alexander W Lange; Jeffrey A Whitsett
Sox2 activates cell proliferation and differentiation in the respiratory epithelium.
American journal of respiratory cell and molecular biology 2011;45(1):101-10.
2011: Jeffrey A Whitsett; Vladimir V Kalinichenko
Notch and basal cells take center stage during airway epithelial regeneration.
Cell stem cell 2011;8(6):597-8.
2011: Timothy D Le Cras; Thomas H Acciani; Elizabeth M Mushaben; Elizabeth L Kramer; Patricia A Pastura; William D Hardie; Thomas R Korfhagen; Umasundari Sivaprasad; Mark Ericksen; Aaron M Gibson; Michael J Holtzman; Jeffrey A Whitsett; Gurjit K Khurana Hershey
Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma.
American journal of physiology. Lung cellular and molecular physiology 2011;300(3):L414-21.
2011: Anne-Karina T Perl; Dieter Riethmacher; Jeffrey A Whitsett
Conditional depletion of airway progenitor cells induces peribronchiolar fibrosis.
American journal of respiratory and critical care medicine 2011;183(4):511-21.
2011: Valerie Besnard; Leah Rae Donahue; Caleb Heffner; Machiko Ikegami; Stephen A Murray; Susan E Wert; Yan Xu; Jeffrey A Whitsett
Maternal synchronization of gestational length and lung maturation.
PloS one 2011;6(11):e26682.
2010: Anon Srikiatkhachorn; Jyothi Chintapalli; Jun Liu; Mohammad Jamaluddin; Kevin S Harrod; Jeffrey A Whitsett; Richard I Enelow; chilakamarti ramana
Interference with intraepithelial TNF-α signaling inhibits CD8(+) T-cell-mediated lung injury in influenza infection.
Viral immunology 2010;23(6):639-45.
2010: Suh-Chin J Lin; Maqsood A Wani; Jeffrey A Whitsett; James M Wells
Klf5 regulates lineage formation in the pre-implantation mouse embryo.
Development (Cambridge, England) 2010;137(23):3953-63.
2010: I-Ching Wang; Yufang Zhang; Jonathan Snyder; Mardi J Sutherland; MS Burhans; John M Shannon; Hyun Jung Park; Jeffrey A Whitsett; Vladimir V. Kalinichenko
Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia.
Developmental biology 2010;347(2):301-14.
2010: Takuji Suzuki; Takuro Sakagami; Lisa R Young; Brenna C Carey; Robert E Wood; Maurizio Luisetti; Susan E Wert; Bruce K Rubin; Katharine Kevill; Claudia Chalk; Jeffrey A Whitsett; Carrie Stevens; Lawrence M Nogee; Ilaria Campo; Bruce C Trapnell
Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy.
American journal of respiratory and critical care medicine 2010;182(10):1292-304.
2010: W Adam Gower; Susan E Wert; Jennifer S Ginsberg; Agneta Golan; Jeffrey A Whitsett; Lawrence M Nogee
Fatal familial lung disease caused by ABCA3 deficiency without identified ABCA3 mutations.
The Journal of pediatrics 2010;157(1):62-8.
2010: Takuro Sakagami; David Beck; Kanji Uchida; Takuji Suzuki; Brenna C Carey; Koh Nakata; Gary Keller; Robert E Wood; Susan E Wert; Machiko Ikegami; Jeffrey A Whitsett; Maurizio Luisetti; Stella Davies; Jeffrey P Krischer; Alan Brody; Fred Ryckman; Bruce C Trapnell
Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates.
American journal of respiratory and critical care medicine 2010;182(1):49-61.
2010: Gang Chen; Huajing Wan; Fengming Luo; Liqian Zhang; Yan Xu; Ian Lewkowich; MARSHA WILLS-KARP; Jeffrey A Whitsett
Foxa2 programs Th2 cell-mediated innate immunity in the developing lung.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6133-41.
2010: Jeffrey A Whitsett
Review: The intersection of surfactant homeostasis and innate host defense of the lung: lessons from newborn infants.
Innate immunity 2010;16(3):138-42.
2010: Atsuyasu Sato; Jeffrey A Whitsett; Ronald K Scheule; Machiko Ikegami
Surfactant protein-d inhibits lung inflammation caused by ventilation in premature newborn lambs.
American journal of respiratory and critical care medicine 2010;181(10):1098-105.
2010: Valerie Besnard; Yohei Matsuzaki; Jean Clark; Yan Xu; Susan E Wert; Machiko Ikegami; Mildred T Stahlman; Timothy E Weaver; Alan N Hunt; Anthony D Postle; Jeffrey A Whitsett
Conditional deletion of Abca3 in alveolar type II cells alters surfactant homeostasis in newborn and adult mice.
American journal of physiology. Lung cellular and molecular physiology 2010;298(5):L646-59.
2010: Paul S Kingma; Jeffrey A Whitsett
The pulmonary collectins and respiratory syncytial virus: is there a clinical link?
The Journal of pediatrics 2010;156(3):349-50.
2010: Timothy D Le Cras; Thomas R Korfhagen; Cynthia Davidson; Stephanie Schmidt; Matthew Fenchel; Machiko Ikegami; Jeffrey A Whitsett; William D Hardie
Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis.
The American journal of pathology 2010;176(2):679-86.
2010: Yan Xu; Minlu Zhang; Yanhua Wang; Pooja Kadambi; Vrushank Dave; Long J Lu; Jeffrey A Whitsett
A systems approach to mapping transcriptional networks controlling surfactant homeostasis.
BMC genomics 2010;11():451.
2010: Jeffrey A Whitsett; Susan E Wert; Timothy E Weaver
Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease.
Annual review of medicine 2010;61():105-19.
2009: Thomas R Korfhagen; Timothy D Le Cras; Cynthia R Davidson; Stephanie M Schmidt; Machiko Ikegami; Jeffrey A Whitsett; William D Hardie
Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis.
American journal of respiratory cell and molecular biology 2009;41(5):562-72.
2009: Machiko Ikegami; Timothy E Weaver; Shawn N Grant; Jeffrey A Whitsett
Pulmonary surfactant surface tension influences alveolar capillary shape and oxygenation.
American journal of respiratory cell and molecular biology 2009;41(4):433-9.
2009: Elizabeth L Kramer; Elizabeth M Mushaben; Patricia A Pastura; Thomas H Acciani; Gail H Deutsch; Gurjit K Khurana Hershey; Thomas R Korfhagen; William D Hardie; Jeffrey A Whitsett; Timothy D Le Cras
Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice.
American journal of respiratory cell and molecular biology 2009;41(4):415-25.
2009: Wei Lin; Emmanouil Metzakopian; Yannis E Mavromatakis; Nan Gao; Nikolaos Balaskas; Hiroshi Sasaki; James Briscoe; Jeffrey A Whitsett; Martyn Goulding; Klaus H Kaestner; Siew-Lan Ang
Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development.
Developmental biology 2009;333(2):386-96.
2009: Yan Xu; Chika Saegusa; Angelica Schehr; Shawn Grant; Jeffrey A Whitsett; Machiko Ikegami
C/EBP{alpha} is required for pulmonary cytoprotection during hyperoxia.
American journal of physiology. Lung cellular and molecular physiology 2009;297(2):L286-98.
2009: Jason R Spence; Alex W Lange; Suh-Chin J Lin; Klaus kaestner; Andrew M Lowy; Injune Kim; Jeffrey A Whitsett; James M Wells
Sox17 regulates organ lineage segregation of ventral foregut progenitor cells.
Developmental cell 2009;17(1):62-74.
2009: Machiko Ikegami; Shawn Grant; Thomas R Korfhagen; Ronald K Scheule; Jeffrey A Whitsett
Surfactant protein-D regulates the postnatal maturation of pulmonary surfactant lipid pool sizes.
Journal of applied physiology (Bethesda, Md. : 1985) 2009;106(5):1545-52.
2009: Valerie Besnard; Susan E Wert; Mildred T Stahlman; Anthony D Postle; Yan Xu; Machiko Ikegami; Jeffrey A Whitsett
Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts.
The Journal of biological chemistry 2009;284(6):4018-30.
2009: Alexander W Lange; Angela R Keiser; James M Wells; Aaron M Zorn; Jeffrey A Whitsett
Sox17 promotes cell cycle progression and inhibits TGF-beta/Smad3 signaling to initiate progenitor cell behavior in the respiratory epithelium.
PloS one 2009;4(5):e5711.
2008: Tanya V Kalin; I-Ching Wang; Lucille Meliton; Yufang Zhang; Susan E Wert; Xiaomeng Ren; Jonathan Snyder; Sheila M Bell; Lloyd Graf; Jeffrey A Whitsett; Vladimir V. Kalinichenko
Forkhead Box m1 transcription factor is required for perinatal lung function.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):19330-5.
2008: Takuji Suzuki; Takuro Sakagami; Bruce K Rubin; Lawrence M Nogee; Robert E Wood; Sarah L Zimmerman; Teresa Smolarek; Megan K Dishop; Susan E Wert; Jeffrey A Whitsett; Gregory Grabowski; Brenna C Carey; Carrie Stevens; Johannes C M van der Loo; Bruce C Trapnell
Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.
The Journal of experimental medicine 2008;205(12):2703-10.
2008: Tanya V Kalin; Lucille Meliton; Angelo Y Meliton; Xiangdong Zhu; Jeffrey A Whitsett; Vladimir V. Kalinichenko
Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene.
American journal of respiratory cell and molecular biology 2008;39(4):390-9.
2008: Wellington Cardoso; Jeffrey A Whitsett
Resident cellular components of the lung: developmental aspects.
Proceedings of the American Thoracic Society 2008;5(7):767-71.
2008: Tinnakorn chaiworapongsa; Joon-Seok Hong; William M Hull; Roberto Romero; Jeffrey A Whitsett
Amniotic fluid concentration of surfactant proteins in intra-amniotic infection.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2008;21(9):663-70.
2008: Tinnakorn chaiworapongsa; Joon-Seok Hong; William M Hull; Chong Jai Kim; Ricardo Gomez; Moshe Mazor; Roberto Romero; Jeffrey A Whitsett
The concentration of surfactant protein-A in amniotic fluid decreases in spontaneous human parturition at term.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2008;21(9):652-9.
2008: Huajing Wan; Fengming Luo; Susan E Wert; Liqian Zhang; Yan Xu; Machiko Ikegami; Yutaka Maeda; Sheila M Bell; Jeffrey A Whitsett
Kruppel-like factor 5 is required for perinatal lung morphogenesis and function.
Development (Cambridge, England) 2008;135(15):2563-72.
2008: Stephan W Glasser; Albert P Senft; Jeffrey A Whitsett; Melissa D Maxfield; Gary F Ross; Theresa R Richardson; Daniel R Prows; Yan Xu; Thomas R Korfhagen
Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):621-8.
2008: Yuzhen Zhang; Ashley Goss; Ethan David Cohen; Rachel Kadzik; John J Lepore; Karthika Muthukumaraswamy; Jifu Yang; Francesco J DeMayo; Jeffrey A Whitsett; Michael S Parmacek; Edward Morrisey
A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration.
Nature genetics 2008;40(7):862-70.
2008: Yutaka Maeda; Takuji Suzuki; Xiufang Pan; Gang Chen; Songqin Pan; Thomas Bartman; Jeffrey A Whitsett
CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis.
The Journal of biological chemistry 2008;283(23):16084-92.
2008: Hiroshi Kida; Michael L Mucenski; Angela R Thitoff; Timothy D Le Cras; Kwon-Sik Park; Machiko Ikegami; Werner Muller; Jeffrey A Whitsett
GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium.
The American journal of pathology 2008;172(6):1542-54.
2008: William D Hardie; Cynthia Davidson; Machiko Ikegami; George Leikauf; Timothy D Le Cras; Adrienne Prestridge; Jeffrey A Whitsett; Thomas R Korfhagen
EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology 2008;294(6):L1217-25.
2008: Machiko Ikegami; Angelica Falcone; Jeffrey A Whitsett
STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;104(6):1753-60.
2008: Lee J Quinton; Matthew R Jones; Bryanne E Robson; Benjamin T Simms; Jeffrey A Whitsett; Joseph P Mizgerd
Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia.
American journal of respiratory cell and molecular biology 2008;38(6):699-706.
2008: Eric B Brandt; Melissa K Mingler; Michelle D Stevenson; Ning Wang; Gurjit K Khurana Hershey; Jeffrey A Whitsett; Marc E Rothenberg
Surfactant protein D alters allergic lung responses in mice and human subjects.
The Journal of allergy and clinical immunology 2008;121(5):1140-1147.e2.
2008: Yohei Matsuzaki; Valerie Besnard; Jean C Clark; Yan Xu; Susan E Wert; Machiko Ikegami; Jeffrey A Whitsett
STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells.
American journal of respiratory cell and molecular biology 2008;38(5):551-8.
2008: Jeffrey A Whitsett
Hereditary disorders of surfactant homeostasis cause acute and chronic lung disease in infancy.
Thorax 2008;63(4):295-6.
2008: Jianping Sun; Hui Chen; Cheng Chen; Jeffrey A Whitsett; Yuji Mishina; Pablo Bringas; Jeffrey C Ma; David Warburton; Wei Shi
Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation.
The American journal of pathology 2008;172(3):571-82.
2008: Sheila M Bell; Claire M Schreiner; Susan E Wert; Michael L Mucenski; William J Scott; Jeffrey A Whitsett
R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis.
Development (Cambridge, England) 2008;135(6):1049-58.
2008: Vrushank Davé; Susan E Wert; Tiffany Tanner; Angela R Thitoff; David E Loudy; Jeffrey A Whitsett
Conditional deletion of Pten causes bronchiolar hyperplasia.
American journal of respiratory cell and molecular biology 2008;38(3):337-45.
2008: Phuoc Tran; Alice C Fan; Pavan K Bendapudi; Shan Koh; Kim Komatsubara; Joy Chen; George Horng; David I Bellovin; Sylvie Giuriato; Craig S Wang; Jeffrey A Whitsett; Dean W Felsher
Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas.
PloS one 2008;3(5):e2125.
2008: Kathy E Wedig; Jeffrey A Whitsett
Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition.
The Journal of pediatrics 2008;152(1):140, 140.e1.
2007: Valerie Besnard; Yan Xu; Jeffrey A Whitsett
Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression.
American journal of physiology. Lung cellular and molecular physiology 2007;293(6):L1395-405.
2007: Machiko Ikegami; Elizabeth A Scoville; Shawn Grant; Thomas R Korfhagen; William Brondyk; Ronald K Scheule; Jeffrey A Whitsett
Surfactant protein-D and surfactant inhibit endotoxin-induced pulmonary inflammation.
Chest 2007;132(5):1447-54.
2007: Jay Tichelaar; Scott C Wesselkamper; Supurna Chowdhury; Hulian Yin; Pierre-Yves Berclaz; Maureen Sartor; George Leikauf; Jeffrey A Whitsett
Duration-dependent cytoprotective versus inflammatory effects of lung epithelial fibroblast growth factor-7 expression.
Experimental lung research 2007;33(8-9):385-417.
2007: Shigehisa Yanagi; Hiroyuki Kishimoto; Kohichi Kawahara; Takehiko Sasaki; Masato Sasaki; Miki Nishio; Nobuyuki Yajima; Koichi Hamada; Yasuo Horie; Hiroshi Kubo; Jeffrey A Whitsett; Tak Wah Mak; Toru Nakano; Masamitsu Nakazato; Akira Suzuki
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice.
The Journal of clinical investigation 2007;117(10):2929-40.
2007: William D Hardie; Thomas R Korfhagen; Maureen Sartor; Adrienne Prestridge; Mario Medvedovic; Timothy D Le Cras; Machiko Ikegami; Scott C Wesselkamper; Cynthia Davidson; Maggie Dietsch; William Nichols; Jeffrey A Whitsett; George Leikauf
Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.
American journal of respiratory cell and molecular biology 2007;37(3):309-21.
2007: Anna L M Ferri; Wei Lin; Yannis E Mavromatakis; Julie C Wang; Hiroshi Sasaki; Jeffrey A Whitsett; Siew-Lan Ang
Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner.
Development (Cambridge, England) 2007;134(15):2761-9.
2007: Hiroaki Yamamoto; Eun Jun Yun; Hans-Peter Gerber; Napoleone Ferrara; Jeffrey A Whitsett; Thiennu H Vu
Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis.
Developmental biology 2007;308(1):44-53.
2007: Kwon-Sik Park; Thomas R Korfhagen; Michael D Bruno; Joseph A Kitzmiller; Huajing Wan; Susan E Wert; Gurjit K Khurana Hershey; Gang Chen; Jeffrey A Whitsett
SPDEF regulates goblet cell hyperplasia in the airway epithelium.
The Journal of clinical investigation 2007;117(4):978-88.
2007: Ola Didrik Saugstad; Thor Willy Ruud Hansen; Arild Rønnestad; Britt Nakstad; Per Arne Tølløfsrud; Finn P Reinholt; Aaron Hamvas; F Sessions Coles; Michael Dean; Susan E Wert; Jeffrey A Whitsett; Lawrence M Nogee
Novel mutations in the gene encoding ATP binding cassette protein member A3 (ABCA3) resulting in fatal neonatal lung disease.
Acta paediatrica (Oslo, Norway : 1992) 2007;96(2):185-90.
2007: Albert P Senft; Thomas R Korfhagen; Jeffrey A Whitsett; Ann Marie Levine
Surfactant protein D regulates the cell surface expression of alveolar macrophage beta(2)-integrins.
American journal of physiology. Lung cellular and molecular physiology 2007;292(2):L469-75.
2007: Yan Xu; Machiko Ikegami; Yanhua Wang; Yohei Matsuzaki; Jeffrey A Whitsett
Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells.
BMC genomics 2007;8():455.
2007: Yutaka Maeda; Vrushank Davé; Jeffrey A Whitsett
Transcriptional control of lung morphogenesis.
Physiological reviews 2007;87(1):219-44.
2007: Mildred T Stahlman; Valerie Besnard; Susan E Wert; Timothy E Weaver; Sharon Dingle; Yan Xu; Kara von Zychlin; Sandra J Olson; Jeffrey A Whitsett
Expression of ABCA3 in developing lung and other tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007;55(1):71-83.
2007: Pierre-Yves Berclaz; Brenna Carey; Marie-Dominique Fillipi; Kara Wernke-Dollries; Nick Geraci; Stephanie Cush; Terry Richardson; Joseph A Kitzmiller; Michael O'Connor; Christina Hermoyian; Thomas R Korfhagen; Jeffrey A Whitsett; Bruce C Trapnell
GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS.
American journal of respiratory cell and molecular biology 2007;36(1):114-21.
2007: Kristina Bry; Jeffrey A Whitsett; Urpo Lappalainen
IL-1beta disrupts postnatal lung morphogenesis in the mouse.
American journal of respiratory cell and molecular biology 2007;36(1):32-42.
2006: Adrienne Prestridge; Jamie Wooldridge; Gail H Deutsch; Lisa R Young; Susan E Wert; Jeffrey A Whitsett; Lawrence M Nogee
Persistent tachypnea and hypoxia in a 3-month-old term infant.
The Journal of pediatrics 2006;149(5):702-706.
2006: Jeffrey A Whitsett; Yohei Matsuzaki
Transcriptional regulation of perinatal lung maturation.
Pediatric clinics of North America 2006;53(5):873-87, viii.
2006: Vrushank Davé; Tawanna Childs; Yan Xu; Machiko Ikegami; Valerie Besnard; Yutaka Maeda; Susan E Wert; Joel R Neilson; Gerald R Crabtree; Jeffrey A Whitsett
Calcineurin/Nfat signaling is required for perinatal lung maturation and function.
The Journal of clinical investigation 2006;116(10):2597-609.
2006: Hiroko Akei; Jeffrey A Whitsett; Michelle Buroker; Takafumi Ninomiya; Haruyuki Tatsumi; Timothy E Weaver; Machiko Ikegami
Surface tension influences cell shape and phagocytosis in alveolar macrophages.
American journal of physiology. Lung cellular and molecular physiology 2006;291(4):L572-9.
2006: Paul S Kingma; Liqian Zhang; Machiko Ikegami; Kevan L Hartshorn; Francis X McCormack; Jeffrey A Whitsett
Correction of pulmonary abnormalities in Sftpd-/- mice requires the collagenous domain of surfactant protein D.
The Journal of biological chemistry 2006;281(34):24496-505.
2006: Liqian Zhang; Machiko Ikegami; Thomas R Korfhagen; Francis X McCormack; Mitsuhiro Yoshida; Robert M Senior; J Michael Shipley; Steven D Shapiro; Jeffrey A Whitsett
Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis.
American journal of physiology. Lung cellular and molecular physiology 2006;291(2):L181-90.
2006: Yohei Matsuzaki; Yan Xu; Machiko Ikegami; Valerie Besnard; Kwon-Sik Park; William M Hull; Susan E Wert; Jeffrey A Whitsett
Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):527-37.
2006: Machiko Ikegami; Karen Carter; Kimberly Bishop; Annuradha Yadav; Elizabeth Masterjohn; William Brondyk; Ronald K Scheule; Jeffrey A Whitsett
Intratracheal recombinant surfactant protein d prevents endotoxin shock in the newborn preterm lamb.
American journal of respiratory and critical care medicine 2006;173(12):1342-7.
2006: Tami H Garmany; Michael A Moxley; Frances V White; Michael Dean; William M Hull; Jeffrey A Whitsett; Lawrence M Nogee; Aaron Hamvas
Surfactant composition and function in patients with ABCA3 mutations.
Pediatric research 2006;59(6):801-5.
2006: Paul S Kingma; Jeffrey A Whitsett
In defense of the lung: surfactant protein A and surfactant protein D.
Current opinion in pharmacology 2006;6(3):277-83.
2006: Kwon-Sik Park; James M Wells; Aaron M Zorn; Susan E Wert; Jeffrey A Whitsett
Sox17 influences the differentiation of respiratory epithelial cells.
Developmental biology 2006;294(1):192-202.
2006: Jeffrey A Whitsett; Anne-Karina T Perl
Conditional control of gene expression in the respiratory epithelium: A cautionary note.
American journal of respiratory cell and molecular biology 2006;34(5):519-20.
2006: Yan Xu; Cong Liu; Jean C Clark; Jeffrey A Whitsett
Functional genomic responses to cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR(delta508) in the lung.
The Journal of biological chemistry 2006;281(16):11279-91.
2006: Yutaka Maeda; Thomas C Hunter; David E Loudy; Vrushank Davé; Valérie Schreiber; Jeffrey A Whitsett
PARP-2 interacts with TTF-1 and regulates expression of surfactant protein-B.
The Journal of biological chemistry 2006;281(14):9600-6.
2006: Jörg Köhl; Ralf Baelder; Ian Lewkowich; Manoj K Pandey; Heiko Hawlisch; Lihua Wang; Jennifer Best; Nancy S Herman; Alyssa A Sproles; Jörg Zwirner; Jeffrey A Whitsett; Craig Gerard; Georgia Sfyroera; John D Lambris; MARSHA WILLS-KARP
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma.
The Journal of clinical investigation 2006;116(3):783-96.
2006: Prithy C Martis; Jeffrey A Whitsett; Yan Xu; Anne-Karina T Perl; Huajing Wan; Machiko Ikegami
C/EBPalpha is required for lung maturation at birth.
Development (Cambridge, England) 2006;133(6):1155-64.
2006: Kwon-Sik Park; James M Wells; Aaron M Zorn; Susan E Wert; Victor E Laubach; Lucas Guillermo Fernandez; Jeffrey A Whitsett
Transdifferentiation of ciliated cells during repair of the respiratory epithelium.
American journal of respiratory cell and molecular biology 2006;34(2):151-7.
2006: Jeffrey A Whitsett
Disorders of lung morphogenesis.
Paediatric respiratory reviews 2006;7 Suppl 1():S248.
2006: Jeffrey A Whitsett
Genetic disorders of surfactant homeostasis.
Paediatric respiratory reviews 2006;7 Suppl 1():S240-2.
2006: Mitsuhiro Yoshida; Jeffrey A Whitsett
Alveolar macrophages and emphysema in surfactant protein-D-deficient mice.
Respirology (Carlton, Vic.) 2006;11 Suppl():S37-40.
2005: Heather S Floyd; Charles L Farnsworth; Nancy D Kock; Melissa C Mizesko; Joy L Little; Stephanie T Dance; Jeff Everitt; Jay Tichelaar; Jeffrey A Whitsett; Mark Steven Miller
Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model.
Carcinogenesis 2005;26(12):2196-206.
2005: Michael L Mucenski; Jennifer M Nation; Angela R Thitoff; Valerie Besnard; Yan Xu; Susan E Wert; Naomoto Harada; Makoto M Taketo; Mildred T Stahlman; Jeffrey A Whitsett
Beta-catenin regulates differentiation of respiratory epithelial cells in vivo.
American journal of physiology. Lung cellular and molecular physiology 2005;289(6):L971-9.
2005: Machiko Ikegami; Jeffrey A Whitsett; Prithy C Martis; Timothy E Weaver
Reversibility of lung inflammation caused by SP-B deficiency.
American journal of physiology. Lung cellular and molecular physiology 2005;289(6):L962-70.
2005: William E Lawson; Vasiliy V Polosukhin; georgios stathopoulos; Ornella Zoia; Wei Han; Kirk B Lane; Bo Li; Edwin F Donnelly; George E Holburn; Kenneth G Lewis; Robert D Collins; William M Hull; Stephan W Glasser; Jeffrey A Whitsett; Timothy S Blackwell
Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin.
The American journal of pathology 2005;167(5):1267-77.
2005: Valerie Besnard; Susan E Wert; Klaus kaestner; Jeffrey A Whitsett
Stage-specific regulation of respiratory epithelial cell differentiation by Foxa1.
American journal of physiology. Lung cellular and molecular physiology 2005;289(5):L750-9.
2005: Anne-Karina T Perl; Susan E Wert; David E Loudy; Zhengyuan Shan; Paula A Blair; Jeffrey A Whitsett
Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli.
American journal of respiratory cell and molecular biology 2005;33(5):455-62.
2005: Janine E Bullard; Susan E Wert; Jeffrey A Whitsett; Michael Dean; Lawrence M Nogee
ABCA3 mutations associated with pediatric interstitial lung disease.
American journal of respiratory and critical care medicine 2005;172(8):1026-31.
2005: Ching-Hui Yang; Jacek Szeliga; Jeremy Jordan; Shawn Faske; Zvjezdana Sever-Chroneos; Bre Dorsett; Robert E Christian; Robert E Settlage; Jeffrey Shabanowitz; Donald F Hunt; Jeffrey A Whitsett; Zissis C Chroneos
Identification of the surfactant protein A receptor 210 as the unconventional myosin 18A.
The Journal of biological chemistry 2005;280(41):34447-57.
2005: Weiguo Shu; Susan H Guttentag; Zhishan Wang; Thomas Andl; Philip L Ballard; Min Min Lu; Stefano Piccolo; Walter Birchmeier; Jeffrey A Whitsett; Sarah E Millar; Edward Morrisey
Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung.
Developmental biology 2005;283(1):226-39.
2005: Machiko Ikegami; Timothy D Le Cras; William D Hardie; Mildred T Stahlman; Jeffrey A Whitsett; Thomas R Korfhagen
TGF-alpha perturbs surfactant homeostasis in vivo.
American journal of physiology. Lung cellular and molecular physiology 2005;289(1):L34-43.
2005: Lori L Nesslein; Kristin R Melton; Machiko Ikegami; Cheng-Lun Na; Susan E Wert; Ward R Rice; Jeffrey A Whitsett; Timothy E Weaver
Partial SP-B deficiency perturbs lung function and causes air space abnormalities.
American journal of physiology. Lung cellular and molecular physiology 2005;288(6):L1154-61.
2005: Becky J Proskocil; Harmanjatinder S Sekhon; Jennifer A Clark; Stacie L Lupo; Yibing Jia; William M Hull; Jeffrey A Whitsett; Barry Starcher; Eliot R Spindel
Vitamin C prevents the effects of prenatal nicotine on pulmonary function in newborn monkeys.
American journal of respiratory and critical care medicine 2005;171(9):1032-9.
2005: Albert P Senft; Thomas R Korfhagen; Jeffrey A Whitsett; Steven D Shapiro; Ann Marie Levine
Surfactant protein-D regulates soluble CD14 through matrix metalloproteinase-12.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4953-9.
2005: Huajing Wan; Sharon Dingle; Yan Xu; Valerie Besnard; Klaus kaestner; Siew-Lan Ang; Susan E Wert; Mildred T Stahlman; Jeffrey A Whitsett
Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis.
The Journal of biological chemistry 2005;280(14):13809-16.
2005: Urpo Lappalainen; Jeffrey A Whitsett; Susan E Wert; Jay Tichelaar; Kristina Bry
Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung.
American journal of respiratory cell and molecular biology 2005;32(4):311-8.
2005: H Scott Cameron; Marco Somaschini; Paola Carrera; Aaron Hamvas; Jeffrey A Whitsett; Susan E Wert; Gail H Deutsch; Lawrence M Nogee
A common mutation in the surfactant protein C gene associated with lung disease.
The Journal of pediatrics 2005;146(3):370-5.
2005: Machiko Ikegami; Cheng-Lun Na; Thomas R Korfhagen; Jeffrey A Whitsett
Surfactant protein D influences surfactant ultrastructure and uptake by alveolar type II cells.
American journal of physiology. Lung cellular and molecular physiology 2005;288(3):L552-61.
2005: Jeffrey A Whitsett
Surfactant proteins in innate host defense of the lung.
Biology of the neonate 2005;88(3):175-80.
2005: Jeffrey A Whitsett; Susan E Wert; Yan Xu
Genetic disorders of surfactant homeostasis.
Biology of the neonate 2005;87(4):283-7.
2005: Anne-Karina T Perl; Ralf Kist; Zhengyuan Shan; Gerd Scherer; Jeffrey A Whitsett
Normal lung development and function after Sox9 inactivation in the respiratory epithelium.
Genesis (New York, N.Y. : 2000) 2005;41(1):23-32.
2005: Ann L Akeson; James E Cameron; Timothy D Le Cras; Jeffrey A Whitsett; James M Greenberg
Vascular endothelial growth factor-A induces prenatal neovascularization and alters bronchial development in mice.
Pediatric research 2005;57(1):82-8.
2004: Valerie Besnard; Susan E Wert; William M Hull; Jeffrey A Whitsett
Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues.
Gene expression patterns : GEP 2004;5(2):193-208.
2004: Huajing Wan; Yan Xu; Machiko Ikegami; Mildred T Stahlman; Klaus kaestner; Siew-Lan Ang; Jeffrey A Whitsett
Foxa2 is required for transition to air breathing at birth.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(40):14449-54.
2004: Jeffrey A Whitsett; Susan E Wert; Bruce C Trapnell
Genetic disorders influencing lung formation and function at birth.
Human molecular genetics 2004;13 Spec No 2():R207-15.
2004: Timothy D Le Cras; William D Hardie; Gail H Deutsch; K H Albertine; Machiko Ikegami; Jeffrey A Whitsett; Thomas R Korfhagen
Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood.
American journal of physiology. Lung cellular and molecular physiology 2004;287(4):L718-29.
2004: Leigh-Anne D Miller; Susan E Wert; Jean C Clark; Yan Xu; Anne-Karina T Perl; Jeffrey A Whitsett
Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;231(1):57-71.
2004: Paul R Reynolds; Michael L Mucenski; Timothy D Le Cras; William C Nichols; Jeffrey A Whitsett
Midkine is regulated by hypoxia and causes pulmonary vascular remodeling.
The Journal of biological chemistry 2004;279(35):37124-32.
2004: Vrushank Davé; Tawanna Childs; Jeffrey A Whitsett
Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (Sftpd) via direct interaction with thyroid transcription factor-1 in lung epithelial cells.
The Journal of biological chemistry 2004;279(33):34578-88.
2004: Ann Marie Levine; James Elliott; Jeffrey A Whitsett; Anon Srikiatkhachorn; Erika Crouch; Nihal DeSilva; Thomas R Korfhagen
Surfactant protein-d enhances phagocytosis and pulmonary clearance of respiratory syncytial virus.
American journal of respiratory cell and molecular biology 2004;31(2):193-9.
2004: Timothy D Le Cras; R E Spitzmiller; K H Albertine; James M Greenberg; Jeffrey A Whitsett; Ann L Akeson
VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice.
American journal of physiology. Lung cellular and molecular physiology 2004;287(1):L134-42.
2004: Ravi elluru; Jeffrey A Whitsett
Potential role of Sox9 in patterning tracheal cartilage ring formation in an embryonic mouse model.
Archives of otolaryngology--head & neck surgery 2004;130(6):732-6.
2004: Andras Khoor; Mildred T Stahlman; Jean M Johnson; Sandra J Olson; Jeffrey A Whitsett
Forkhead box A2 transcription factor is expressed in all types of neuroendocrine lung tumors.
Human pathology 2004;35(5):560-4.
2004: Kwon-Sik Park; Jeffrey A Whitsett; Tina Di Palma; Jeong-Ho Hong; Michael B Yaffe; Mariastella Zannini
TAZ interacts with TTF-1 and regulates expression of surfactant protein-C.
The Journal of biological chemistry 2004;279(17):17384-90.
2004: Christopher L Karp; Leah M Flick; Kiwon W Park; Samir Softic; Todd M Greer; Raquel Keledjian; Rong Yang; Jasim Uddin; William B Guggino; Sowsan F Atabani; Yasmine Belkaid; Yan Xu; Jeffrey A Whitsett; Frank J Accurso; MARSHA WILLS-KARP; Nicos A Petasis
Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway.
Nature immunology 2004;5(4):388-92.
2004: Sergey Shulenin; Lawrence M Nogee; Tarmo Annilo; Susan E Wert; Jeffrey A Whitsett; Michael Dean
ABCA3 gene mutations in newborns with fatal surfactant deficiency.
The New England journal of medicine 2004;350(13):1296-303.
2004: Isamu Hokuto; Anne-Karina T Perl; Jeffrey A Whitsett
FGF signaling is required for pulmonary homeostasis following hyperoxia.
American journal of physiology. Lung cellular and molecular physiology 2004;286(3):L580-7.
2004: Vladimir V. Kalinichenko; Galina A Gusarova; Il-Man Kim; Brian Shin; Helena M Yoder; Jean Clark; Alexander M Sapozhnikov; Jeffrey A Whitsett; Robert H Costa
Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development.
American journal of physiology. Lung cellular and molecular physiology 2004;286(3):L521-30.
2004: Huajing Wan; Klaus kaestner; Siew-Lan Ang; Machiko Ikegami; Fred D Finkelman; Mildred T Stahlman; Patricia C Fulkerson; Marc E Rothenberg; Jeffrey A Whitsett
Foxa2 regulates alveolarization and goblet cell hyperplasia.
Development (Cambridge, England) 2004;131(4):953-64.
2004: M Yoshida; Jeffrey A Whitsett
Interactions between pulmonary surfactant and alveolar macrophages in the pathogenesis of lung disease.
Cellular and molecular biology (Noisy-le-Grand, France) 2004;50 Online Pub():OL639-48.
2004: Isamu Hokuto; Machiko Ikegami; Mitsuhiro Yoshida; Kiyoshi Takeda; Shizuo Akira; Anne-Karina T Perl; William M Hull; Susan E Wert; Jeffrey A Whitsett
Stat-3 is required for pulmonary homeostasis during hyperoxia.
The Journal of clinical investigation 2004;113(1):28-37.
2003: Bruce C Trapnell; Jeffrey A Whitsett; Koh Nakata
Pulmonary alveolar proteinosis.
The New England journal of medicine 2003;349(26):2527-39.
2003: Ann L Akeson; James M Greenberg; James E Cameron; Felisa Y Thompson; Sherry K Brooks; Diane Wiginton; Jeffrey A Whitsett
Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung.
Developmental biology 2003;264(2):443-55.
2003: Cong Liu; Machiko Ikegami; Mildred T Stahlman; Chitta R Dey; Jeffrey A Whitsett
Inhibition of alveolarization and altered pulmonary mechanics in mice expressing GATA-6.
American journal of physiology. Lung cellular and molecular physiology 2003;285(6):L1246-54.
2003: Timothy D Le Cras; William D Hardie; Karen A Fagan; Jeffrey A Whitsett; Thomas R Korfhagen
Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing transforming growth factor-alpha.
American journal of physiology. Lung cellular and molecular physiology 2003;285(5):L1046-54.
2003: Michael L Mucenski; Susan E Wert; Jennifer M Nation; David E Loudy; Joerg Huelsken; Walter Birchmeier; Edward Morrisey; Jeffrey A Whitsett
beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis.
The Journal of biological chemistry 2003;278(41):40231-8.
2003: Terry L Noah; Paula C Murphy; Jorien J Alink; Margaret W Leigh; William M Hull; Mildred T Stahlman; Jeffrey A Whitsett
Bronchoalveolar lavage fluid surfactant protein-A and surfactant protein-D are inversely related to inflammation in early cystic fibrosis.
American journal of respiratory and critical care medicine 2003;168(6):685-91.
2003: Mario DeFelice; Daniel Silberschmidt; Roberto DiLauro; Yan Xu; Susan E Wert; Timothy E Weaver; Cindy J Bachurski; Jean C Clark; Jeffrey A Whitsett
TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression.
The Journal of biological chemistry 2003;278(37):35574-83.
2003: Kristin R Melton; Lori L Nesslein; Machiko Ikegami; Jay Tichelaar; Jean C Clark; Jeffrey A Whitsett; Timothy E Weaver
SP-B deficiency causes respiratory failure in adult mice.
American journal of physiology. Lung cellular and molecular physiology 2003;285(3):L543-9.
2003: Sophie Chabot; Kamen Koumanov; Gérard Lambeau; Michael H Gelb; Viviane Balloy; Michel Chignard; Jeffrey A Whitsett; Lhousseine Touqui
Inhibitory effects of surfactant protein A on surfactant phospholipid hydrolysis by secreted phospholipases A2.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):995-1000.
2003: Anne-Karina T Perl; Isamu Hokuto; Maria-Antonietta Impagnatiello; Gerhard Christofori; Jeffrey A Whitsett
Temporal effects of Sprouty on lung morphogenesis.
Developmental biology 2003;258(1):154-68.
2003: Paul R Reynolds; Michael L Mucenski; Jeffrey A Whitsett
Thyroid transcription factor (TTF) -1 regulates the expression of midkine (MK) during lung morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 2003;227(2):227-37.
2003: Stephan W Glasser; Emily A Detmer; Machiko Ikegami; Cheng-Lun Na; Mildred T Stahlman; Jeffrey A Whitsett
Pneumonitis and emphysema in sp-C gene targeted mice.
The Journal of biological chemistry 2003;278(16):14291-8.
2003: Rachel A Collins; Machiko Ikegami; Thomas R Korfhagen; Jeffrey A Whitsett; Peter David Sly
In vivo measurements of changes in respiratory mechanics with age in mice deficient in surfactant protein D.
Pediatric research 2003;53(3):463-7.
2003: Ralph Epaud; Machiko Ikegami; Jeffrey A Whitsett; Alan H Jobe; Timothy E Weaver; Henry T Akinbi
Surfactant protein B inhibits endotoxin-induced lung inflammation.
American journal of respiratory cell and molecular biology 2003;28(3):373-8.
2003: Yan Xu; Jean C Clark; Bruce Aronow; Chitta R Dey; Cong Liu; Jamie L Wooldridge; Jeffrey A Whitsett
Transcriptional adaptation to cystic fibrosis transmembrane conductance regulator deficiency.
The Journal of biological chemistry 2003;278(9):7674-82.
2003: Isamu Hokuto; Anne-Karina T Perl; Jeffrey A Whitsett
Prenatal, but not postnatal, inhibition of fibroblast growth factor receptor signaling causes emphysema.
The Journal of biological chemistry 2003;278(1):415-21.
2002: Jeffrey A Whitsett; Timothy E Weaver
Hydrophobic surfactant proteins in lung function and disease.
The New England journal of medicine 2002;347(26):2141-8.
2002: Pierre-Yves Berclaz; Zsuzsanna Zsengellér; Yoko Shibata; Kazuhisa Otake; Steven Strasbaugh; Jeffrey A Whitsett; Bruce C Trapnell
Endocytic internalization of adenovirus, nonspecific phagocytosis, and cytoskeletal organization are coordinately regulated in alveolar macrophages by GM-CSF and PU.1.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6332-42.
2002: Pierre-Yves Berclaz; Yoko Shibata; Jeffrey A Whitsett; Bruce C Trapnell
GM-CSF, via PU.1, regulates alveolar macrophage Fcgamma R-mediated phagocytosis and the IL-18/IFN-gamma -mediated molecular connection between innate and adaptive immunity in the lung.
Blood 2002;100(12):4193-200.
2002: Liqian Zhang; Machiko Ikegami; Chitta R Dey; Thomas R Korfhagen; Jeffrey A Whitsett
Reversibility of pulmonary abnormalities by conditional replacement of surfactant protein D (SP-D) in vivo.
The Journal of biological chemistry 2002;277(41):38709-13.
2002: Ming Du; Julie R Jones; Jessica Lanier; Kim M Keeling; J Russell Lindsey; Albert Tousson; Zsuzsa Bebök; Jeffrey A Whitsett; Chitta R Dey; William H Colledge; Martin J Evans; Eric J Sorscher; David M Bedwell
Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgene.
Journal of molecular medicine (Berlin, Germany) 2002;80(9):595-604.
2002: Anne-Karina T Perl; Susan E Wert; Andras Nagy; Corrinne G Lobe; Jeffrey A Whitsett
Early restriction of peripheral and proximal cell lineages during formation of the lung.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10482-7.
2002: Cong Liu; Edward Morrisey; Jeffrey A Whitsett
GATA-6 is required for maturation of the lung in late gestation.
American journal of physiology. Lung cellular and molecular physiology 2002;283(2):L468-75.
2002: Nades Palaniyar; Liquian Zhang; Alexander Kuzmenko; Machiko Ikegami; Sijue Wan; Huixing Wu; Thomas R Korfhagen; Jeffrey A Whitsett; Francis X McCormack
The role of pulmonary collectin N-terminal domains in surfactant structure, function, and homeostasis in vivo.
The Journal of biological chemistry 2002;277(30):26971-9.
2002: Liqian Zhang; Kevan L Hartshorn; Erika C Crouch; Machiko Ikegami; Jeffrey A Whitsett
Complementation of pulmonary abnormalities in SP-D(-/-) mice with an SP-D/conglutinin fusion protein.
The Journal of biological chemistry 2002;277(25):22453-9.
2002: Jeffrey A Whitsett; Jean C Clark; Lara Picard; Jay Tichelaar; Susan E Wert; Nobuyuki Itoh; Anne-Karina T Perl; Mildred T Stahlman
Fibroblast growth factor 18 influences proximal programming during lung morphogenesis.
The Journal of biological chemistry 2002;277(25):22743-9.
2002: Vladimir V. Kalinichenko; Yan Zhou; Brian Shin; Donna B Stolz; simon simon watkins; Jeffrey A Whitsett; Robert H Costa
Wild-type levels of the mouse Forkhead Box f1 gene are essential for lung repair.
American journal of physiology. Lung cellular and molecular physiology 2002;282(6):L1253-65.
2002: Jeffrey A Whitsett
Genetic basis of familial interstitial lung disease: misfolding or function of surfactant protein C?
American journal of respiratory and critical care medicine 2002;165(9):1201-2.
2002: Mildred T Stahlman; Mary E Gray; William M Hull; Jeffrey A Whitsett
Immunolocalization of surfactant protein-D (SP-D) in human fetal, newborn, and adult tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002;50(5):651-60.
2002: Honghua Yang; Min Min Lu; Lili Zhang; Jeffrey A Whitsett; Edward Morrisey
GATA6 regulates differentiation of distal lung epithelium.
Development (Cambridge, England) 2002;129(9):2233-46.
2002: Lorena Lim; Vladimir V. Kalinichenko; Jeffrey A Whitsett; Robert H Costa
Fusion of lung lobes and vessels in mouse embryos heterozygous for the forkhead box f1 targeted allele.
American journal of physiology. Lung cellular and molecular physiology 2002;282(5):L1012-22.
2002: Francis X McCormack; Jeffrey A Whitsett
The pulmonary collectins, SP-A and SP-D, orchestrate innate immunity in the lung.
The Journal of clinical investigation 2002;109(6):707-12.
2002: Lawrence M Nogee; Alston E Dunbar; Susan E Wert; Frederic B Askin; Aaron Hamvas; Jeffrey A Whitsett
Mutations in the surfactant protein C gene associated with interstitial lung disease.
Chest 2002;121(3 Suppl):20S-21S.
2002: Jeffrey A Whitsett
Intrinsic and innate defenses in the lung: intersection of pathways regulating lung morphogenesis, host defense, and repair.
The Journal of clinical investigation 2002;109(5):565-9.
2002: Susan E Wert; Chitta R Dey; Paula A Blair; Shioko Kimura; Jeffrey A Whitsett
Increased expression of thyroid transcription factor-1 (TTF-1) in respiratory epithelial cells inhibits alveolarization and causes pulmonary inflammation.
Developmental biology 2002;242(2):75-87.
2002: Cong Liu; Stephan W Glasser; Huajing Wan; Jeffrey A Whitsett
GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression.
The Journal of biological chemistry 2002;277(6):4519-25.
2002: Anne-Karina T Perl; Jay Tichelaar; Jeffrey A Whitsett
Conditional gene expression in the respiratory epithelium of the mouse.
Transgenic research 2002;11(1):21-9.
2002: Sonya D Johnston; Christopher B Daniels; David Cenzato; Jeffrey A Whitsett; Sandra Orgeig
The pulmonary surfactant system matures upon pipping in the freshwater turtle Chelydra serpentina.
The Journal of experimental biology 2002;205(Pt 3):415-25.
2002: Machiko Ikegami; Timothy E Weaver; Juliana J Conkright; Peter David Sly; Gary F Ross; Jeffrey A Whitsett; Stephan W Glasser
Deficiency of SP-B reveals protective role of SP-C during oxygen lung injury.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;92(2):519-26.
2002: Bruce C Trapnell; Jeffrey A Whitsett
Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense.
Annual review of physiology 2002;64():775-802.
2001: L A Miller; Susan E Wert; Jeffrey A Whitsett
Immunolocalization of sonic hedgehog (Shh) in developing mouse lung.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001;49(12):1593-604.
2001: Carissa M Krane; CN Fortner; A R Hand; Dennis W McGraw; John N Lorenz; Susan E Wert; JE Towne; Richard J Paul; Jeffrey A Whitsett; Anil G Menon
Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):14114-9.
2001: Ann Marie Levine; Jeffrey A Whitsett; Kevan L Hartshorn; Erika C Crouch; Thomas R Korfhagen
Surfactant protein D enhances clearance of influenza A virus from the lung in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5868-73.
2001: Machiko Ikegami; BM Elhalwagi; Nades Palaniyar; KM Dienger; Thomas R Korfhagen; Jeffrey A Whitsett; Francis X McCormack
The collagen-like region of surfactant protein A (SP-A) is required for correction of surfactant structural and functional defects in the SP-A null mouse.
The Journal of biological chemistry 2001;276(42):38542-8.
2001: Yoko Shibata; Pierre-Yves Berclaz; ZC Chroneos; Mitsuhiro Yoshida; Jeffrey A Whitsett; Bruce C Trapnell
GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1.
Immunity 2001;15(4):557-67.
2001: Machiko Ikegami; William M Hull; Mitsuhiro Yoshida; Susan E Wert; Jeffrey A Whitsett
SP-D and GM-CSF regulate surfactant homeostasis via distinct mechanisms.
American journal of physiology. Lung cellular and molecular physiology 2001;281(3):L697-703.
2001: Vladimir V. Kalinichenko; Lorena Lim; Donna B Stolz; Brian Shin; Francisco M Rausa; J Clark; Jeffrey A Whitsett; simon simon watkins; Robert H Costa
Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor.
Developmental biology 2001;235(2):489-506.
2001: X Zeng; M Gray; Mildred T Stahlman; Jeffrey A Whitsett
TGF-beta1 perturbs vascular development and inhibits epithelial differentiation in fetal lung in vivo.
Developmental dynamics : an official publication of the American Association of Anatomists 2001;221(3):289-301.
2001: Jeffrey A Whitsett; Stephan W Glasser; Jay Tichelaar; Anne-Karina T Perl; Jean C Clark; Susan E Wert
Transgenic models for study of lung morphogenesis and repair: Parker B. Francis lecture.
Chest 2001;120(1 Suppl):27S-30S.
2001: Raouf S Amin; Susan E Wert; R P Baughman; J F Tomashefski; Lawrence M Nogee; Alan S Brody; William M Hull; Jeffrey A Whitsett
Surfactant protein deficiency in familial interstitial lung disease.
The Journal of pediatrics 2001;139(1):85-92.
2001: Mitsuhiro Yoshida; Thomas R Korfhagen; Jeffrey A Whitsett
Surfactant protein D regulates NF-kappa B and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7514-9.
2001: L Zhang; Machiko Ikegami; Erika C Crouch; Thomas R Korfhagen; Jeffrey A Whitsett
Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure.
The Journal of biological chemistry 2001;276(22):19214-9.
2001: Stephan W Glasser; MS Burhans; Thomas R Korfhagen; Cheng-Lun Na; Peter David Sly; Gary F Ross; Machiko Ikegami; Jeffrey A Whitsett
Altered stability of pulmonary surfactant in SP-C-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6366-71.
2001: L D Miller; Susan E Wert; Jeffrey A Whitsett
Surfactant proteins and cell markers in the respiratory epithelium of the amphibian, Ambystoma mexicanum.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2001;129(1):141-9.
2001: Jean C Clark; Jay Tichelaar; Susan E Wert; N Itoh; Anne-Karina T Perl; Mildred T Stahlman; Jeffrey A Whitsett
FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo.
American journal of physiology. Lung cellular and molecular physiology 2001;280(4):L705-15.
2001: Michael J Linke; Chad E Harris; Thomas R Korfhagen; Francis X McCormack; Alan D Ashbaugh; Paul E Steele; Jeffrey A Whitsett; Peter D Walzer
Immunosuppressed surfactant protein A-deficient mice have increased susceptibility to Pneumocystis carinii infection.
The Journal of infectious diseases 2001;183(6):943-52.
2001: Zsuzsanna Zsengellér; Gary F Ross; Bruce C Trapnell; Csaba Szabó; Jeffrey A Whitsett
Adenovirus infection increases iNOS and peroxynitrite production in the lung.
American journal of physiology. Lung cellular and molecular physiology 2001;280(3):L503-11.
2001: Mitsuhiro Yoshida; Machiko Ikegami; JA Reed; ZC Chroneos; Jeffrey A Whitsett
GM-CSF regulates protein and lipid catabolism by alveolar macrophages.
American journal of physiology. Lung cellular and molecular physiology 2001;280(3):L379-86.
2001: Lawrence M Nogee; Alston E Dunbar; Susan E Wert; Frederic B Askin; Aaron Hamvas; Jeffrey A Whitsett
A mutation in the surfactant protein C gene associated with familial interstitial lung disease.
The New England journal of medicine 2001;344(8):573-9.
2001: Ann Marie Levine; Jeffrey A Whitsett
Pulmonary collectins and innate host defense of the lung.
Microbes and infection / Institut Pasteur 2001;3(2):161-6.
2000: Angela Naltner; Susan E Wert; Jeffrey A Whitsett; Cong Yan
Temporal/spatial expression of nuclear receptor coactivators in the mouse lung.
American journal of physiology. Lung cellular and molecular physiology 2000;279(6):L1066-74.
2000: ZC Chroneos; Susan E Wert; J L Livingston; D J Hassett; Jeffrey A Whitsett
Role of cystic fibrosis transmembrane conductance regulator in pulmonary clearance of Pseudomonas aeruginosa in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):3941-50.
2000: Ann Marie Levine; Jeffrey A Whitsett; J A Gwozdz; T R Richardson; James H Fisher; MS Burhans; Thomas R Korfhagen
Distinct effects of surfactant protein A or D deficiency during bacterial infection on the lung.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):3934-40.
2000: Alston E Dunbar; Susan E Wert; M Ikegami; Jeffrey A Whitsett; Aaron Hamvas; Frances V White; B Piedboeuf; Christian Jobin; Susan H Guttentag; Lawrence M Nogee
Prolonged survival in hereditary surfactant protein B (SP-B) deficiency associated with a novel splicing mutation.
Pediatric research 2000;48(3):275-82.
2000: Machiko Ikegami; Jeffrey A Whitsett; Alan H Jobe; G Ross; J Fisher; Thomas R Korfhagen
Surfactant metabolism in SP-D gene-targeted mice.
American journal of physiology. Lung cellular and molecular physiology 2000;279(3):L468-76.
2000: S Hayashida; KS Harrod; Jeffrey A Whitsett
Regulation and function of CCSP during pulmonary Pseudomonas aeruginosa infection in vivo.
American journal of physiology. Lung cellular and molecular physiology 2000;279(3):L452-9.
2000: Machiko Ikegami; Alan H Jobe; Jeffrey A Whitsett; Thomas R Korfhagen
Tolerance of SP-A-deficient mice to hyperoxia or exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;89(2):644-8.
2000: JA Reed; Machiko Ikegami; L Robb; C G Begley; G Ross; Jeffrey A Whitsett
Distinct changes in pulmonary surfactant homeostasis in common beta-chain- and GM-CSF-deficient mice.
American journal of physiology. Lung cellular and molecular physiology 2000;278(6):L1164-71.
2000: Susan E Wert; Mitsuhiro Yoshida; Ann Marie Levine; Machiko Ikegami; T Jones; Gary F Ross; James H Fisher; Thomas R Korfhagen; Jeffrey A Whitsett
Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5972-7.
2000: Jay Tichelaar; W Lu; Jeffrey A Whitsett
Conditional expression of fibroblast growth factor-7 in the developing and mature lung.
The Journal of biological chemistry 2000;275(16):11858-64.
2000: KS Harrod; A D Mounday; Jeffrey A Whitsett
Adenoviral E3-14.7K protein in LPS-induced lung inflammation.
American journal of physiology. Lung cellular and molecular physiology 2000;278(4):L631-9.
2000: Mildred T Stahlman; M P Gray; M W Falconieri; Jeffrey A Whitsett; Timothy E Weaver
Lamellar body formation in normal and surfactant protein B-deficient fetal mice.
Laboratory investigation; a journal of technical methods and pathology 2000;80(3):395-403.
2000: Lawrence M Nogee; Susan E Wert; S A Proffit; William M Hull; Jeffrey A Whitsett
Allelic heterogeneity in hereditary surfactant protein B (SP-B) deficiency.
American journal of respiratory and critical care medicine 2000;161(3 Pt 1):973-81.
2000: Robert Paine; Angela M Preston; Steven E Wilcoxen; Hong Jin; B B Siu; Susan B Morris; J A Reed; G Ross; Jeffrey A Whitsett; James M Beck
Granulocyte-macrophage colony-stimulating factor in the innate immune response to Pneumocystis carinii pneumonia in mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2602-9.
2000: DC Beck; Cheng-Lun Na; Jeffrey A Whitsett; Timothy E Weaver
Ablation of a critical surfactant protein B intramolecular disulfide bond in transgenic mice.
The Journal of biological chemistry 2000;275(5):3371-6.
2000: DC Beck; Machiko Ikegami; Cheng-Lun Na; S Zaltash; Jan Johansson; Jeffrey A Whitsett; Timothy E Weaver
The role of homodimers in surfactant protein B function in vivo.
The Journal of biological chemistry 2000;275(5):3365-70.
2000: James H Fisher; V Sheftelyevich; Ye-Shih Ho; S Fligiel; Francis X McCormack; Thomas R Korfhagen; Jeffrey A Whitsett; Machiko Ikegami
Pulmonary-specific expression of SP-D corrects pulmonary lipid accumulation in SP-D gene-targeted mice.
American journal of physiology. Lung cellular and molecular physiology 2000;278(2):L365-73.
2000: Michael D Bruno; Thomas R Korfhagen; Cong Liu; Edward Morrisey; Jeffrey A Whitsett
GATA-6 activates transcription of surfactant protein A.
The Journal of biological chemistry 2000;275(2):1043-9.
2000: Angela Naltner; M Ghaffari; Jeffrey A Whitsett; Cong Yan
Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent.
The Journal of biological chemistry 2000;275(1):56-62.
2000: A L Byrd-Gloster; Andras Khoor; L Frank Glass; J L Messina; Jeffrey A Whitsett; S K Livingston; P T Cagle
Differential expression of thyroid transcription factor 1 in small cell lung carcinoma and Merkel cell tumor.
Human pathology 2000;31(1):58-62.
2000: Machiko Ikegami; Jeffrey A Whitsett; ZC Chroneos; Gary F Ross; JA Reed; Cindy J Bachurski; Alan H Jobe
IL-4 increases surfactant and regulates metabolism in vivo.
American journal of physiology. Lung cellular and molecular physiology 2000;278(1):L75-80.
1999: K Tokieda; Machiko Ikegami; Susan E Wert; John E Baatz; Y Zou; Jeffrey A Whitsett
Surfactant protein B corrects oxygen-induced pulmonary dysfunction in heterozygous surfactant protein B-deficient mice.
Pediatric research 1999;46(6):708-14.
1999: Machiko Ikegami; KS Harrod; Jeffrey A Whitsett; Alan H Jobe
CCSP deficiency does not alter surfactant homeostasis during adenoviral infection.
The American journal of physiology 1999;277(5 Pt 1):L983-7.
1999: K Tokieda; HS Iwamoto; Cindy J Bachurski; Susan E Wert; William M Hull; K Ikeda; Jeffrey A Whitsett
Surfactant protein-B-deficient mice are susceptible to hyperoxic lung injury.
American journal of respiratory cell and molecular biology 1999;21(4):463-72.
1999: Michael D Bruno; Jeffrey A Whitsett; Gary F Ross; Thomas R Korfhagen
Transcriptional regulation of the murine surfactant protein-A gene by B-Myb.
The Journal of biological chemistry 1999;274(39):27523-8.
1999: Jay Tichelaar; L Lim; R H Costa; Jeffrey A Whitsett
HNF-3/forkhead homologue-4 influences lung morphogenesis and respiratory epithelial cell differentiation in vivo.
Developmental biology 1999;213(2):405-17.
1999: KS Harrod; Bruce C Trapnell; Kazuhisa Otake; Thomas R Korfhagen; Jeffrey A Whitsett
SP-A enhances viral clearance and inhibits inflammation after pulmonary adenoviral infection.
The American journal of physiology 1999;277(3 Pt 1):L580-8.
1999: William D Hardie; Pablo A Bejarano; M A Miller; James R Yankaskas; J H Ritter; Jeffrey A Whitsett; Thomas R Korfhagen
Immunolocalization of transforming growth factor alpha and epidermal growth factor receptor in lungs of patients with cystic fibrosis.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 1999;2(5):415-23.
1999: Jeffrey A Whitsett; Jay Tichelaar
Forkhead transcription factor HFH-4 and respiratory epithelial cell differentiation.
American journal of respiratory cell and molecular biology 1999;21(2):153-4.
1999: S Lin; Cheng-Lun Na; Henry T Akinbi; K S Apsley; Jeffrey A Whitsett; Timothy E Weaver
Surfactant protein B (SP-B) -/- mice are rescued by restoration of SP-B expression in alveolar type II cells but not Clara cells.
The Journal of biological chemistry 1999;274(27):19168-74.
1999: Z Sever-Chroneos; Cindy J Bachurski; Cong Yan; Jeffrey A Whitsett
Regulation of mouse SP-B gene promoter by AP-1 family members.
The American journal of physiology 1999;277(1 Pt 1):L79-88.
1999: Andras Khoor; Jeffrey A Whitsett; Mildred T Stahlman; Sandra J Olson; P T Cagle
Utility of surfactant protein B precursor and thyroid transcription factor 1 in differentiating adenocarcinoma of the lung from malignant mesothelioma.
Human pathology 1999;30(6):695-700.
1999: Jay Tichelaar; Susan E Wert; R H Costa; S Kimura; Jeffrey A Whitsett
HNF-3/forkhead homologue-4 (HFH-4) is expressed in ciliated epithelial cells in the developing mouse lung.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999;47(6):823-32.
1999: JA Reed; Machiko Ikegami; E R Cianciolo; W Lu; P S Cho; William M Hull; Alan H Jobe; Jeffrey A Whitsett
Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice.
The American journal of physiology 1999;276(4 Pt 1):L556-63.
1999: Ann Marie Levine; J Gwozdz; J Stark; M Bruno; Jeffrey A Whitsett; Thomas R Korfhagen
Surfactant protein-A enhances respiratory syncytial virus clearance in vivo.
The Journal of clinical investigation 1999;103(7):1015-21.
1999: Harmanjatinder S Sekhon; Yibing Jia; R Raab; Alexander Kuryatov; James F Pankow; Jeffrey A Whitsett; Jon Lindstrom; Eliot R Spindel
Prenatal nicotine increases pulmonary alpha7 nicotinic receptor expression and alters fetal lung development in monkeys.
The Journal of clinical investigation 1999;103(5):637-47.
1999: M Ghaffari; Jeffrey A Whitsett; Cong Yan
Inhibition of hSP-B promoter in respiratory epithelial cells by a dominant negative retinoic acid receptor.
The American journal of physiology 1999;276(3 Pt 1):L398-404.
1999: Zsuzsanna Zsengellér; C Halbert; A D Miller; Susan E Wert; Jeffrey A Whitsett; Cindy J Bachurski
Keratinocyte growth factor stimulates transduction of the respiratory epithelium by retroviral vectors.
Human gene therapy 1999;10(3):341-53.
1999: Ann Marie Levine; J A Reed; KE Kurak; E Cianciolo; Jeffrey A Whitsett
GM-CSF-deficient mice are susceptible to pulmonary group B streptococcal infection.
The Journal of clinical investigation 1999;103(4):563-9.
1999: Ann Marie Levine; KE Kurak; J R Wright; W T Watford; Michael D Bruno; Gary F Ross; Jeffrey A Whitsett; Thomas R Korfhagen
Surfactant protein-A binds group B streptococcus enhancing phagocytosis and clearance from lungs of surfactant protein-A-deficient mice.
American journal of respiratory cell and molecular biology 1999;20(2):279-86.
1999: J R Shaw-White; Michael D Bruno; Jeffrey A Whitsett
GATA-6 activates transcription of thyroid transcription factor-1.
The Journal of biological chemistry 1999;274(5):2658-64.
1999: HS Iwamoto; Bruce C Trapnell; CJ McConnell; C Daugherty; Jeffrey A Whitsett
Pulmonary inflammation associated with repeated, prenatal exposure to an E1, E3-deleted adenoviral vector in sheep.
Gene therapy 1999;6(1):98-106.
1998: Jeffrey A Whitsett; Stephan W Glasser
Regulation of surfactant protein gene transcription.
Biochimica et biophysica acta 1998;1408(2-3):303-11.
1998: Thomas R Korfhagen; Ann Marie Levine; Jeffrey A Whitsett
Surfactant protein A (SP-A) gene targeted mice.
Biochimica et biophysica acta 1998;1408(2-3):296-302.
1998: H A Harlamert; J Mira; Pablo A Bejarano; R P Baughman; MA Miller; Jeffrey A Whitsett; Rawia Yassin
Thyroid transcription factor-1 and cytokeratins 7 and 20 in pulmonary and breast carcinoma.
Acta cytologica 1998;42(6):1382-8.
1998: KS Harrod; A D Mounday; B R Stripp; Jeffrey A Whitsett
Clara cell secretory protein decreases lung inflammation after acute virus infection.
The American journal of physiology 1998;275(5 Pt 1):L924-30.
1998: Thomas R Korfhagen; V Sheftelyevich; MS Burhans; Michael D Bruno; Gary F Ross; Susan E Wert; Mildred T Stahlman; Alan H Jobe; Machiko Ikegami; Jeffrey A Whitsett; James H Fisher
Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo.
The Journal of biological chemistry 1998;273(43):28438-43.
1998: X Zeng; Katherine E Yutzey; Jeffrey A Whitsett
Thyroid transcription factor-1, hepatocyte nuclear factor-3beta and surfactant protein A and B in the developing chick lung.
Journal of anatomy 1998;193 ( Pt 3)():399-408.
1998: Ann Marie Levine; KE Kurak; Michael D Bruno; James M Stark; Jeffrey A Whitsett; Thomas R Korfhagen
Surfactant protein-A-deficient mice are susceptible to Pseudomonas aeruginosa infection.
American journal of respiratory cell and molecular biology 1998;19(4):700-8.
1998: Zsuzsanna Zsengellér; JA Reed; Cindy J Bachurski; Ann Marie Levine; S Forry-Schaudies; Raphael Hirsch; Jeffrey A Whitsett
Adenovirus-mediated granulocyte-macrophage colony-stimulating factor improves lung pathology of pulmonary alveolar proteinosis in granulocyte-macrophage colony-stimulating factor-deficient mice.
Human gene therapy 1998;9(14):2101-9.
1998: Gary F Ross; Michael D Bruno; M Uyeda; K Suzuki; K Nagao; Jeffrey A Whitsett; Thomas R Korfhagen
Enhanced reporter gene expression in cells transfected in the presence of DMI-2, an acid nuclease inhibitor.
Gene therapy 1998;5(9):1244-50.
1998: KS Harrod; TW Hermiston; Bruce C Trapnell; William S M Wold; Jeffrey A Whitsett
Lung-specific expression of adenovirus E3-14.7K in transgenic mice attenuates adenoviral vector-mediated lung inflammation and enhances transgene expression.
Human gene therapy 1998;9(13):1885-98.
1998: S Jain-Vora; Ann Marie Levine; ZC Chroneos; Gary F Ross; William M Hull; Jeffrey A Whitsett
Interleukin-4 enhances pulmonary clearance of Pseudomonas aeruginosa.
Infection and immunity 1998;66(9):4229-36.
1998: Machiko Ikegami; Thomas R Korfhagen; Jeffrey A Whitsett; Michael D Bruno; Susan E Wert; K Wada; Alan H Jobe
Characteristics of surfactant from SP-A-deficient mice.
The American journal of physiology 1998;275(2 Pt 1):L247-54.
1998: Cong Yan; M Ghaffari; Jeffrey A Whitsett; X Zeng; Z Sever; S Lin
Retinoic acid-receptor activation of SP-B gene transcription in respiratory epithelial cells.
The American journal of physiology 1998;275(2 Pt 1):L239-46.
1998: Mildred T Stahlman; Mary E Gray; Jeffrey A Whitsett
Temporal-spatial distribution of hepatocyte nuclear factor-3beta in developing human lung and other foregut derivatives.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(8):955-62.
1998: JA Reed; Jeffrey A Whitsett
Granulocyte-macrophage colony-stimulating factor and pulmonary surfactant homeostasis.
Proceedings of the Association of American Physicians 1998;110(4):321-32.
1998: Machiko Ikegami; Ann D Horowitz; Jeffrey A Whitsett; Alan H Jobe
Clearance of SP-C and recombinant SP-C in vivo and in vitro.
The American journal of physiology 1998;274(6 Pt 1):L933-9.
1998: Jeffrey A Whitsett; Mildred T Stahlman
Impact of advances in physiology, biochemistry, and molecular biology on pulmonary disease in neonates.
American journal of respiratory and critical care medicine 1998;157(4 Pt 2):S67-71.
1998: X Zeng; Susan E Wert; R Federici; K G Peters; Jeffrey A Whitsett
VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis in vivo.
Developmental dynamics : an official publication of the American Association of Anatomists 1998;211(3):215-27.
1998: Lucy C Sullivan; Christopher B Daniels; I D Phillips; Sandra Orgeig; Jeffrey A Whitsett
Conservation of surfactant protein A: evidence for a single origin for vertebrate pulmonary surfactant.
Journal of molecular evolution 1998;46(2):131-8.
1997: M Ghaffari; X Zeng; Jeffrey A Whitsett; Cong Yan
Nuclear localization domain of thyroid transcription factor-1 in respiratory epithelial cells.
The Biochemical journal 1997;328 ( Pt 3)():757-61.
1997: L Zhou; C R Dey; Susan E Wert; Cong Yan; R H Costa; Jeffrey A Whitsett
Hepatocyte nuclear factor-3beta limits cellular diversity in the developing respiratory epithelium and alters lung morphogenesis in vivo.
Developmental dynamics : an official publication of the American Association of Anatomists 1997;210(3):305-14.
1997: S Jain-Vora; Susan E Wert; Ulla-Angela Temann; JA Rankin; Jeffrey A Whitsett
Interleukin-4 alters epithelial cell differentiation and surfactant homeostasis in the postnatal mouse lung.
American journal of respiratory cell and molecular biology 1997;17(5):541-51.
1997: K Tokieda; Jeffrey A Whitsett; Jean C Clark; Timothy E Weaver; K Ikeda; K B McConnell; Alan H Jobe; Machiko Ikegami; HS Iwamoto
Pulmonary dysfunction in neonatal SP-B-deficient mice.
The American journal of physiology 1997;273(4 Pt 1):L875-82.
1997: J A Huffman Reed; Ward R Rice; Zsuzsanna Zsengellér; Susan E Wert; Glenn Dranoff; Jeffrey A Whitsett
GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice.
The American journal of physiology 1997;273(4 Pt 1):L715-25.
1997: Machiko Ikegami; Alan H Jobe; J A Huffman Reed; Jeffrey A Whitsett
Surfactant metabolic consequences of overexpression of GM-CSF in the epithelium of GM-CSF-deficient mice.
The American journal of physiology 1997;273(4 Pt 1):L709-14.
1997: William D Hardie; Michael D Bruno; K M Huelsman; H S Iwamoto; patricia carrigan; George Leikauf; Jeffrey A Whitsett; Thomas R Korfhagen
Postnatal lung function and morphology in transgenic mice expressing transforming growth factor-alpha.
The American journal of pathology 1997;151(4):1075-83.
1997: Ann D Horowitz; KE Kurak; B Moussavian; Jeffrey A Whitsett; Susan E Wert; William M Hull; J McNanie; Machiko Ikegami
Preferential uptake of small-aggregate fraction of pulmonary surfactant in vitro.
The American journal of physiology 1997;273(2 Pt 1):L468-77.
1997: Zsuzsanna Zsengellér; Susan E Wert; Cindy J Bachurski; K L Kirwin; Bruce C Trapnell; Jeffrey A Whitsett
Recombinant adenoviral vector disrupts surfactant homeostasis in mouse lung.
Human gene therapy 1997;8(11):1331-44.
1997: Cong Yan; Jeffrey A Whitsett
Protein kinase A activation of the surfactant protein B gene is mediated by phosphorylation of thyroid transcription factor 1.
The Journal of biological chemistry 1997;272(28):17327-32.
1997: Ann D Horowitz; B Moussavian; E D Han; John E Baatz; Jeffrey A Whitsett
Distinct effects of SP-A and SP-B on endocytosis of SP-C by pulmonary epithelial cells.
The American journal of physiology 1997;273(1 Pt 1):L159-71.
1997: Kathryn Ann Wikenheiser-Brokamp; Jeffrey A Whitsett
Tumor progression and cellular differentiation of pulmonary adenocarcinomas in SV40 large T antigen transgenic mice.
American journal of respiratory cell and molecular biology 1997;16(6):713-23.
1997: Thomas R Korfhagen; Jeffrey A Whitsett
Transcriptional control in the developing lung. The Parker B. Francis lectureship.
Chest 1997;111(6 Suppl):83S-88S.
1997: Zsuzsanna Zsengellér; G P Boivin; S S Sawchuk; Bruce C Trapnell; Jeffrey A Whitsett; Raphael Hirsch
Anti-T cell receptor antibody prolongs transgene expression and reduces lung inflammation after adenovirus-mediated gene transfer.
Human gene therapy 1997;8(8):935-41.
1997: Ann Marie Levine; Michael D Bruno; K M Huelsman; Gary F Ross; Jeffrey A Whitsett; Thomas R Korfhagen
Surfactant protein A-deficient mice are susceptible to group B streptococcal infection.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4336-40.
1997: Henry T Akinbi; J S Breslin; Machiko Ikegami; HS Iwamoto; Jean C Clark; Jeffrey A Whitsett; Alan H Jobe; Timothy E Weaver
Rescue of SP-B knockout mice with a truncated SP-B proprotein. Function of the C-terminal propeptide.
The Journal of biological chemistry 1997;272(15):9640-7.
1997: L Zhang; Kathryn Ann Wikenheiser-Brokamp; Jeffrey A Whitsett
Limitations of retrovirus-mediated HSV-tk gene transfer to pulmonary adenocarcinoma cells in vitro and in vivo.
Human gene therapy 1997;8(5):563-74.
1997: Machiko Ikegami; Thomas R Korfhagen; Michael D Bruno; Jeffrey A Whitsett; Alan H Jobe
Surfactant metabolism in surfactant protein A-deficient mice.
The American journal of physiology 1997;272(3 Pt 1):L479-85.
1997: L Zhang; Jeffrey A Whitsett; B R Stripp
Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1.
Biochimica et biophysica acta 1997;1350(3):359-67.
1997: Andras Khoor; Jeffrey A Whitsett; Mildred T Stahlman; SA Halter
Expression of surfactant protein B precursor and surfactant protein B mRNA in adenocarcinoma of the lung.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1997;10(1):62-7.
1997: Jean C Clark; Timothy E Weaver; HS Iwamoto; Machiko Ikegami; Alan H Jobe; William M Hull; Jeffrey A Whitsett
Decreased lung compliance and air trapping in heterozygous SP-B-deficient mice.
American journal of respiratory cell and molecular biology 1997;16(1):46-52.
1996: L Zhou; R W Graeff; Paul B McCray; W Scott Simonet; Jeffrey A Whitsett
Keratinocyte growth factor stimulates CFTR-independent fluid secretion in the fetal lung in vitro.
The American journal of physiology 1996;271(6 Pt 1):L987-94.
1996: Jeffrey A Whitsett; L Zhou
Use of transgenic mice to study autocrine-paracrine signaling in lung morphogenesis and differentiation.
Clinics in perinatology 1996;23(4):753-69.
1996: Barry R Stripp; J Lund; GW Mango; K C Doyen; C Johnston; K Hultenby; M Nord; Jeffrey A Whitsett
Clara cell secretory protein: a determinant of PCB bioaccumulation in mammals.
The American journal of physiology 1996;271(4 Pt 1):L656-64.
1996: William D Hardie; C B Kerlakian; Michael D Bruno; K M Huelsman; Susan E Wert; Stephan W Glasser; Jeffrey A Whitsett; Thomas R Korfhagen
Reversal of lung lesions in transgenic transforming growth factor alpha mice by expression of mutant epidermal growth factor receptor.
American journal of respiratory cell and molecular biology 1996;15(4):499-508.
1996: L Zhou; L Lim; R H Costa; Jeffrey A Whitsett
Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1996;44(10):1183-93.
1996: Thomas R Korfhagen; Michael D Bruno; Gary F Ross; K M Huelsman; M Ikegami; A H Jobe; Susan E Wert; Barry R Stripp; Randal E Morris; Stephan W Glasser; Cindy J Bachurski; HS Iwamoto; Jeffrey A Whitsett
Altered surfactant function and structure in SP-A gene targeted mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9594-9.
1996: Richard I Enelow; M H Stoler; A Srikiatkhachorn; C Kerlakian; S Agersborg; Jeffrey A Whitsett; Thomas J Braciale
A lung-specific neo-antigen elicits specific CD8+ T cell tolerance with preserved CD4+ T cell reactivity. Implications for immune-mediated lung disease.
The Journal of clinical investigation 1996;98(4):914-22.
1996: J A Rankin; D E Picarella; Gregory P Geba; Ulla-Angela Temann; B Prasad; B DiCosmo; A Tarallo; B Stripp; Jeffrey A Whitsett; Richard A Flavell
Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7821-5.
1996: Z C Chroneos; Rasul Abdolrasulnia; Jeffrey A Whitsett; Ward R Rice; Virginia L Shepherd
Purification of a cell-surface receptor for surfactant protein A.
The Journal of biological chemistry 1996;271(27):16375-83.
1996: Mildred T Stahlman; M E Gray; Jeffrey A Whitsett
Expression of thyroid transcription factor-1(TTF-1) in fetal and neonatal human lung.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1996;44(7):673-8.
1996: K Ikeda; J R Shaw-White; S E Wert; Jeffrey A Whitsett
Hepatocyte nuclear factor 3 activates transcription of thyroid transcription factor 1 in respiratory epithelial cells.
Molecular and cellular biology 1996;16(7):3626-36.
1996: Gloria Pryhuber; Cindy J Bachurski; Raphael Hirsch; A Bacon; Jeffrey A Whitsett
Tumor necrosis factor-alpha decreases surfactant protein B mRNA in murine lung.
The American journal of physiology 1996;270(5 Pt 1):L714-21.
1996: D A Evans; Robert W Wilmott; Jeffrey A Whitsett
Surfactant replacement therapy for adult respiratory distress syndrome in children.
Pediatric pulmonology 1996;21(5):328-36.
1996: L Zhou; C R Dey; Susan E Wert; Jeffrey A Whitsett
Arrested lung morphogenesis in transgenic mice bearing an SP-C-TGF-beta 1 chimeric gene.
Developmental biology 1996;175(2):227-38.
1996: Pablo A Bejarano; Robert P Baughman; Paul Williams Biddinger; MA Miller; Cecilia Fenoglio-Preiser; B al-Kafaji; R Di Lauro; Jeffrey A Whitsett
Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1996;9(4):445-52.
1996: Robert W Wilmott; R S Amin; C R Perez; Susan E Wert; G Keller; Gregory P Boivin; Raphael Hirsch; J De Inocencio; P Lu; S F Reising; S Yei; Jeffrey A Whitsett; Bruce C Trapnell
Safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lungs of nonhuman primates.
Human gene therapy 1996;7(3):301-18.
1996: A Holzinger; S Dingle; Pablo A Bejarano; MA Miller; Timothy E Weaver; R DiLauro; Jeffrey A Whitsett
Monoclonal antibody to thyroid transcription factor-1: production, characterization, and usefulness in tumor diagnosis.
Hybridoma 1996;15(1):49-53.
1996: Jeffrey A Whitsett; Thomas R Korfhagen
Regulation of gene transcription in respiratory epithelial cells.
American journal of respiratory cell and molecular biology 1996;14(2):118-20.
1996: J A Huffman; William M Hull; Glenn Dranoff; R C Mulligan; Jeffrey A Whitsett
Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice.
The Journal of clinical investigation 1996;97(3):649-55.
1996: Ann D Horowitz; B Moussavian; Jeffrey A Whitsett
Roles of SP-A, SP-B, and SP-C in modulation of lipid uptake by pulmonary epithelial cells in vitro.
The American journal of physiology 1996;270(1 Pt 1):L69-79.
1995: W Scott Simonet; Margaret De Rose; N Bucay; H Q Nguyen; S E Wert; L Zhou; T R Ulich; A Thomason; Dimitry M Danilenko; Jeffrey A Whitsett
Pulmonary malformation in transgenic mice expressing human keratinocyte growth factor in the lung.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12461-5.
1995: A Holzinger; Bruce C Trapnell; Timothy E Weaver; Jeffrey A Whitsett; H S Iwamoto
Intraamniotic administration of an adenoviral vector for gene transfer to fetal sheep and mouse tissues.
Pediatric research 1995;38(6):844-50.
1995: D K Vorbroker; WF Voorhout; Timothy E Weaver; Jeffrey A Whitsett
Posttranslational processing of surfactant protein C in rat type II cells.
The American journal of physiology 1995;269(6 Pt 1):L727-33.
1995: Cong Yan; Z Sever; Jeffrey A Whitsett
Upstream enhancer activity in the human surfactant protein B gene is mediated by thyroid transcription factor 1.
The Journal of biological chemistry 1995;270(42):24852-7.
1995: Jeffrey A Whitsett; Lawrence M Nogee; Timothy E Weaver; Ann D Horowitz
Human surfactant protein B: structure, function, regulation, and genetic disease.
Physiological reviews 1995;75(4):749-57.
1995: Cindy J Bachurski; Gloria Pryhuber; Stephan W Glasser; S E Kelly; Jeffrey A Whitsett
Tumor necrosis factor-alpha inhibits surfactant protein C gene transcription.
The Journal of biological chemistry 1995;270(33):19402-7.
1995: Jean C Clark; Susan E Wert; Cindy J Bachurski; Mildred T Stahlman; Barry R Stripp; Timothy E Weaver; Jeffrey A Whitsett
Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):7794-8.
1995: M C Vincent; Bruce C Trapnell; R P Baughman; Susan E Wert; Jeffrey A Whitsett; H S Iwamoto
Adenovirus-mediated gene transfer to the respiratory tract of fetal sheep in utero.
Human gene therapy 1995;6(8):1019-28.
1995: M A Bruno; R J Bohinski; J E Carter; K A Foss; Jeffrey A Whitsett
Structure and function of the mouse surfactant protein B gene.
The American journal of physiology 1995;268(6 Pt 1):section L following t of c.
1995: M A Bruno; R J Bohinski; J E Carter; K A Foss; Jeffrey A Whitsett
Structure and function of the mouse surfactant protein B gene.
The American journal of physiology 1995;268(6 Pt 3):section L 2 p following table of contents.
1995: K Ikeda; Jean C Clark; J R Shaw-White; Mildred T Stahlman; C J Boutell; Jeffrey A Whitsett
Gene structure and expression of human thyroid transcription factor-1 in respiratory epithelial cells.
The Journal of biological chemistry 1995;270(14):8108-14.
1995: R I Sternberg; Jeffrey A Whitsett; William M Hull; Robert P Baughman
Pneumocystis carinii alters surfactant protein A concentrations in bronchoalveolar lavage fluid.
The Journal of laboratory and clinical medicine 1995;125(4):462-9.
1995: Zsuzsanna Zsengeller; Susan E Wert; William M Hull; X Hu; S Yei; Bruce C Trapnell; Jeffrey A Whitsett
Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice.
Human gene therapy 1995;6(4):457-67.
1995: D K Vorbroker; S A Profitt; Lawrence M Nogee; Jeffrey A Whitsett
Aberrant processing of surfactant protein C in hereditary SP-B deficiency.
The American journal of physiology 1995;268(4 Pt 1):L647-56.
1995: Michael D Bruno; R J Bohinski; K M Huelsman; Jeffrey A Whitsett; Thomas R Korfhagen
Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1.
The Journal of biological chemistry 1995;270(12):6531-6.
1995: M A Bruno; R J Bohinski; J E Carter; K A Foss; Jeffrey A Whitsett
Structure and function of the mouse surfactant protein B gene.
The American journal of physiology 1995;268(3 Pt 1):L381-9.
1995: B DiCosmo; Gregory P Geba; D Picarella; Jack A Elias; J A Rankin; B Stripp; Jeffrey A Whitsett; Richard A Flavell
Expression of interleukin-6 by airway epithelial cells. Effects on airway inflammation and hyperreactivity in transgenic mice.
Chest 1995;107(3 Suppl):131S.
1995: Gary F Ross; Randal E Morris; Georgianne M Ciraolo; K Huelsman; M Bruno; Jeffrey A Whitsett; John E Baatz; Thomas R Korfhagen
Surfactant protein A-polylysine conjugates for delivery of DNA to airway cells in culture.
Human gene therapy 1995;6(1):31-40.
1994: L Zhou; C R Dey; Susan E Wert; M D DuVall; R A Frizzell; Jeffrey A Whitsett
Correction of lethal intestinal defect in a mouse model of cystic fibrosis by human CFTR.
Science (New York, N.Y.) 1994;266(5191):1705-8.
1994: Stephan W Glasser; Thomas R Korfhagen; Susan E Wert; Jeffrey A Whitsett
Transgenic models for study of pulmonary development and disease.
The American journal of physiology 1994;267(5 Pt 1):L489-97.
1994: B F DiCosmo; Gregory P Geba; D Picarella; Jack A Elias; J A Rankin; B R Stripp; Jeffrey A Whitsett; Richard A Flavell
Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity.
The Journal of clinical investigation 1994;94(5):2028-35.
1994: S Yei; Cindy J Bachurski; Timothy E Weaver; Susan E Wert; Bruce C Trapnell; Jeffrey A Whitsett
Adenoviral-mediated gene transfer of human surfactant protein B to respiratory epithelial cells.
American journal of respiratory cell and molecular biology 1994;11(3):329-36.
1994: R J Bohinski; R Di Lauro; Jeffrey A Whitsett
The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis.
Molecular and cellular biology 1994;14(9):5671-81.
1994: Andras Khoor; Mildred T Stahlman; M E Gray; Jeffrey A Whitsett
Temporal-spatial distribution of SP-B and SP-C proteins and mRNAs in developing respiratory epithelium of human lung.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1994;42(9):1187-99.
1994: K Ikeda; Jean C Clark; Cindy J Bachurski; Kathryn Ann Wikenheiser-Brokamp; J Cuppoletti; S Mohanti; Randal E Morris; Jeffrey A Whitsett
Immortalization of subpopulations of respiratory epithelial cells from transgenic mice bearing SV40 large T antigen.
The American journal of physiology 1994;267(3 Pt 1):L309-17.
1994: Gloria Pryhuber; S L Church; T Kroft; A Panchal; Jeffrey A Whitsett
3'-untranslated region of SP-B mRNA mediates inhibitory effects of TPA and TNF-alpha on SP-B expression.
The American journal of physiology 1994;267(1 Pt 1):L16-24.
1994: S Yei; N Mittereder; Susan E Wert; Jeffrey A Whitsett; Robert W Wilmott; Bruce C Trapnell
In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung.
Human gene therapy 1994;5(6):731-44.
1994: N Mittereder; S Yei; Cindy J Bachurski; J Cuppoletti; Jeffrey A Whitsett; P Tolstoshev; Bruce C Trapnell
Evaluation of the efficacy and safety of in vitro, adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA.
Human gene therapy 1994;5(6):717-29.
1994: Thomas R Korfhagen; R J Swantz; Susan E Wert; J M McCarty; C B Kerlakian; Stephan W Glasser; Jeffrey A Whitsett
Respiratory epithelial cell expression of human transforming growth factor-alpha induces lung fibrosis in transgenic mice.
The Journal of clinical investigation 1994;93(4):1691-9.
1993: Kathryn Ann Wikenheiser-Brokamp; D K Vorbroker; Ward R Rice; Jean C Clark; Cindy J Bachurski; H K Oie; Jeffrey A Whitsett
Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):11029-33.
1993: Ann D Horowitz; John E Baatz; Jeffrey A Whitsett
Lipid effects on aggregation of pulmonary surfactant protein SP-C studied by fluorescence energy transfer.
Biochemistry 1993;32(37):9513-23.
1993: Andras Khoor; M E Gray; William M Hull; Jeffrey A Whitsett; Mildred T Stahlman
Developmental expression of SP-A and SP-A mRNA in the proximal and distal respiratory epithelium in the human fetus and newborn.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1993;41(9):1311-9.
1993: P L Sawaya; Barry R Stripp; Jeffrey A Whitsett; Donal S Luse
The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families.
Molecular and cellular biology 1993;13(7):3860-71.
1993: R J Bohinski; J A Huffman; Jeffrey A Whitsett; D L Lattier
Cis-active elements controlling lung cell-specific expression of human pulmonary surfactant protein B gene.
The Journal of biological chemistry 1993;268(15):11160-6.
1993: Susan E Wert; Stephan W Glasser; Thomas R Korfhagen; Jeffrey A Whitsett
Transcriptional elements from the human SP-C gene direct expression in the primordial respiratory epithelium of transgenic mice.
Developmental biology 1993;156(2):426-43.
1993: Jeffrey A Whitsett
Training for an academic career in neonatal medicine.
Clinics in perinatology 1993;20(1):1-8.
1993: Robert P Baughman; R I Sternberg; W Hull; J A Buchsbaum; Jeffrey A Whitsett
Decreased surfactant protein A in patients with bacterial pneumonia.
The American review of respiratory disease 1993;147(3):653-7.
1992: JR Wispé; B B Warner; Jean C Clark; C R Dey; J Neuman; Stephan W Glasser; J D Crapo; L Y Chang; Jeffrey A Whitsett
Human Mn-superoxide dismutase in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury.
The Journal of biological chemistry 1992;267(33):23937-41.
1992: John E Baatz; K L Smyth; Jeffrey A Whitsett; C Baxter; D R Absolom
Structure and functions of a dimeric form of surfactant protein SP-C: a Fourier transform infrared and surfactometry study.
Chemistry and physics of lipids 1992;63(1-2):91-104.
1992: Thomas R Korfhagen; Michael D Bruno; Stephan W Glasser; P J Ciraolo; Jeffrey A Whitsett; D L Lattier; Kathryn Ann Wikenheiser-Brokamp; Jean C Clark
Murine pulmonary surfactant SP-A gene: cloning, sequence, and transcriptional activity.
The American journal of physiology 1992;263(5 Pt 1):L546-54.
1992: Mildred T Stahlman; M E Gray; Jeffrey A Whitsett
The ontogeny and distribution of surfactant protein B in human fetuses and newborns.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1992;40(10):1471-80.
1992: Kathryn Ann Wikenheiser-Brokamp; Jean C Clark; R I Linnoila; Mildred T Stahlman; Jeffrey A Whitsett
Simian virus 40 large T antigen directed by transcriptional elements of the human surfactant protein C gene produces pulmonary adenocarcinomas in transgenic mice.
Cancer research 1992;52(19):5342-52.
1992: Jeffrey A Whitsett; C R Dey; Barry R Stripp; Kathryn Ann Wikenheiser-Brokamp; Jean C Clark; Susan E Wert; R J Gregory; A E Smith; J A Cohn; J M Wilson
Human cystic fibrosis transmembrane conductance regulator directed to respiratory epithelial cells of transgenic mice.
Nature genetics 1992;2(1):13-20.
1992: Barry R Stripp; P L Sawaya; Donal S Luse; Kathryn Ann Wikenheiser-Brokamp; Susan E Wert; J A Huffman; D L Lattier; G Singh; S L Katyal; Jeffrey A Whitsett
cis-acting elements that confer lung epithelial cell expression of the CC10 gene.
The Journal of biological chemistry 1992;267(21):14703-12.
1992: Ann D Horowitz; B Elledge; Jeffrey A Whitsett; John E Baatz
Effects of lung surfactant proteolipid SP-C on the organization of model membrane lipids: a fluorescence study.
Biochimica et biophysica acta 1992;1107(1):44-54.
1992: Jeffrey A Whitsett; Jean C Clark; JR Wispé; Gloria Pryhuber
Effects of TNF-alpha and phorbol ester on human surfactant protein and MnSOD gene transcription in vitro.
The American journal of physiology 1992;262(6 Pt 1):L688-93.
1992: T Thorkelsson; Georgianne M Ciraolo; Gary F Ross; Jeffrey A Whitsett; Randal E Morris
Lectin activity of the major surfactant protein (SP-A) may participate in, but is not required for, binding to rat type II cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1992;40(5):643-9.
1992: Mildred T Stahlman; M E Gray; Gary F Ross; William M Hull; Kathryn Ann Wikenheiser-Brokamp; S Dingle; K R Zelenski-Low; Jeffrey A Whitsett
Human surfactant protein-A contains blood group A antigenic determinants.
Pediatric research 1992;31(4 Pt 1):364-71.
1992: D K Vorbroker; C Dey; Timothy E Weaver; Jeffrey A Whitsett
Surfactant protein C precursor is palmitoylated and associates with subcellular membranes.
Biochimica et biophysica acta 1992;1105(1):161-9.
1992: Jeffrey A Whitsett; A Budden; William M Hull; Jean C Clark; M A O'Reilly
Transforming growth factor-beta inhibits surfactant protein A expression in vitro.
Biochimica et biophysica acta 1992;1123(3):257-62.
1992: M A D'Amore-Bruno; Kathryn Ann Wikenheiser-Brokamp; J E Carter; Jean C Clark; Jeffrey A Whitsett
Sequence, ontogeny, and cellular localization of murine surfactant protein B mRNA.
The American journal of physiology 1992;262(1 Pt 1):L40-7.
1992: Kathryn Ann Wikenheiser-Brokamp; Susan E Wert; JR Wispé; Mildred T Stahlman; M D'Amore-Bruno; G Singh; S L Katyal; Jeffrey A Whitsett
Distinct effects of oxygen on surfactant protein B expression in bronchiolar and alveolar epithelium.
The American journal of physiology 1992;262(1 Pt 1):L32-9.
1991: John E Baatz; V Sarin; D R Absolom; C Baxter; Jeffrey A Whitsett
Effects of surfactant-associated protein SP-B synthetic analogs on the structure and surface activity of model membrane bilayers.
Chemistry and physics of lipids 1991;60(2):163-78.
1991: Gloria Pryhuber; William M Hull; I Fink; M J McMahan; Jeffrey A Whitsett
Ontogeny of surfactant proteins A and B in human amniotic fluid as indices of fetal lung maturity.
Pediatric research 1991;30(6):597-605.
1991: Stephan W Glasser; Thomas R Korfhagen; Susan E Wert; Michael D Bruno; K M McWilliams; D K Vorbroker; Jeffrey A Whitsett
Genetic element from human surfactant protein SP-C gene confers bronchiolar-alveolar cell specificity in transgenic mice.
The American journal of physiology 1991;261(4 Pt 1):L349-56.
1991: Thomas R Korfhagen; Stephan W Glasser; Michael D Bruno; M J McMahan; Jeffrey A Whitsett
A portion of the human surfactant protein A (SP-A) gene locus consists of a pseudogene.
American journal of respiratory cell and molecular biology 1991;4(5):463-9.
1991: Jeffrey A Whitsett; William M Hull; S Luse
Failure to detect surfactant protein-specific antibodies in sera of premature infants treated with survanta, a modified bovine surfactant.
Pediatrics 1991;87(4):505-10.
1991: M A O'Reilly; Jean C Clark; Jeffrey A Whitsett
Glucocorticoid enhances pulmonary surfactant protein B gene transcription.
The American journal of physiology 1991;260(2 Pt 1):L37-43.
1991: Lawrence M Nogee; JR Wispé; Jean C Clark; Timothy E Weaver; Jeffrey A Whitsett
Increased expression of pulmonary surfactant proteins in oxygen-exposed rats.
American journal of respiratory cell and molecular biology 1991;4(2):102-7.
1991: Gary F Ross; J Sawyer; T O'Connor; Jeffrey A Whitsett
Intermolecular cross-links mediate aggregation of phospholipid vesicles by pulmonary surfactant protein SP-A.
Biochemistry 1991;30(3):858-65.
1991: Timothy E Weaver; Jeffrey A Whitsett
Function and regulation of expression of pulmonary surfactant-associated proteins.
The Biochemical journal 1991;273(Pt 2)():249-64.
1990: Stephan W Glasser; Thomas R Korfhagen; Michael D Bruno; C Dey; Jeffrey A Whitsett
Structure and expression of the pulmonary surfactant protein SP-C gene in the mouse.
The Journal of biological chemistry 1990;265(35):21986-91.
1990: Gloria Pryhuber; M A O'Reilly; Jean C Clark; William M Hull; I Fink; Jeffrey A Whitsett
Phorbol ester inhibits surfactant protein SP-A and SP-B expression.
The Journal of biological chemistry 1990;265(34):20822-8.
1990: JR Wispé; Jean C Clark; B B Warner; D Fajardo; W E Hull; R B Holtzman; Jeffrey A Whitsett
Tumor necrosis factor-alpha inhibits expression of pulmonary surfactant protein.
The Journal of clinical investigation 1990;86(6):1954-60.
1990: Barry R Stripp; Jeffrey A Whitsett; D L Lattier
Strategies for analysis of gene expression: pulmonary surfactant proteins.
The American journal of physiology 1990;259(4 Pt 1):L185-97.
1990: Thomas R Korfhagen; Stephan W Glasser; Susan E Wert; Michael D Bruno; C C Daugherty; John McNeish; Jeffrey L Stock; steven potter; Jeffrey A Whitsett
Cis-acting sequences from a human surfactant protein gene confer pulmonary-specific gene expression in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(16):6122-6.
1990: John E Baatz; B Elledge; Jeffrey A Whitsett
Surfactant protein SP-B induces ordering at the surface of model membrane bilayers.
Biochemistry 1990;29(28):6714-20.
1990: V K Sarin; S Gupta; T K Leung; V E Taylor; B L Ohning; Jeffrey A Whitsett; J L Fox
Biophysical and biological activity of a synthetic 8.7-kDa hydrophobic pulmonary surfactant protein SP-B.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(7):2633-7.
1989: M A O'Reilly; A F Gazdar; Jean C Clark; T J Pilot-Matias; Susan E Wert; William M Hull; Jeffrey A Whitsett
Glucocorticoids regulate surfactant protein synthesis in a pulmonary adenocarcinoma cell line.
The American journal of physiology 1989;257(6 Pt 1):L385-92.
1989: Ward R Rice; V K Sarin; J L Fox; John E Baatz; Susan E Wert; Jeffrey A Whitsett
Surfactant peptides stimulate uptake of phosphatidylcholine by isolated cells.
Biochimica et biophysica acta 1989;1006(2):237-45.
1989: Lawrence M Nogee; JR Wispé; Jean C Clark; Jeffrey A Whitsett
Increased synthesis and mRNA of surfactant protein A in oxygen-exposed rats.
American journal of respiratory cell and molecular biology 1989;1(2):119-25.
1989: Timothy E Weaver; Jeffrey A Whitsett
Processing of hydrophobic pulmonary surfactant protein B in rat type II cells.
The American journal of physiology 1989;257(2 Pt 1):L100-8.
1989: M A O'Reilly; Timothy E Weaver; T J Pilot-Matias; V K Sarin; A F Gazdar; Jeffrey A Whitsett
In vitro translation, post-translational processing and secretion of pulmonary surfactant protein B precursors.
Biochimica et biophysica acta 1989;1011(2-3):140-8.
1989: R M Ryan; Randal E Morris; Ward R Rice; Georgianne M Ciraolo; Jeffrey A Whitsett
Binding and uptake of pulmonary surfactant protein (SP-A) by pulmonary type II epithelial cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989;37(4):429-40.
1989: T J Pilot-Matias; S E Kister; J L Fox; K Kropp; Stephan W Glasser; Jeffrey A Whitsett
Structure and organization of the gene encoding human pulmonary surfactant proteolipid SP-B.
DNA (Mary Ann Liebert, Inc.) 1989;8(2):75-86.
1989: JR Wispé; Jean C Clark; M S Burhans; K E Kropp; Thomas R Korfhagen; Jeffrey A Whitsett
Synthesis and processing of the precursor for human mangano-superoxide dismutase.
Biochimica et biophysica acta 1989;994(1):30-6.
1988: Lawrence M Nogee; M McMahan; Jeffrey A Whitsett
Hyaline membrane disease and surfactant protein, SAP-35, in diabetes in pregnancy.
American journal of perinatology 1988;5(4):374-7.
1988: Timothy E Weaver; V K Sarin; N Sawtell; William M Hull; Jeffrey A Whitsett
Identification of surfactant proteolipid SP-B in human surfactant and fetal lung.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;65(2):982-7.
1988: Stephan W Glasser; Thomas R Korfhagen; C M Perme; T J Pilot-Matias; S E Kister; Jeffrey A Whitsett
Two SP-C genes encoding human pulmonary surfactant proteolipid.
The Journal of biological chemistry 1988;263(21):10326-31.
1988: Timothy E Weaver; Jeffrey A Whitsett
Structure and function of pulmonary surfactant proteins.
Seminars in perinatology 1988;12(3):213-20.
1988: M A O'Reilly; A F Gazdar; Randal E Morris; Jeffrey A Whitsett
Differential effects of glucocorticoid on expression of surfactant proteins in a human lung adenocarcinoma cell line.
Biochimica et biophysica acta 1988;970(2):194-204.
1988: M A O'Reilly; Lawrence M Nogee; Jeffrey A Whitsett
Requirement of the collagenous domain for carbohydrate processing and secretion of a surfactant protein, SP-A.
Biochimica et biophysica acta 1988;969(2):176-84.
1988: Stephan W Glasser; Thomas R Korfhagen; Timothy E Weaver; Jean C Clark; T Pilot-Matias; J Meuth; J L Fox; Jeffrey A Whitsett
cDNA, deduced polypeptide structure and chromosomal assignment of human pulmonary surfactant proteolipid, SPL(pVal).
The Journal of biological chemistry 1988;263(1):9-12.
1987: Jeffrey A Whitsett; Timothy E Weaver; Jean C Clark; N Sawtell; Stephan W Glasser; Thomas R Korfhagen; William M Hull
Glucocorticoid enhances surfactant proteolipid Phe and pVal synthesis and RNA in fetal lung.
The Journal of biological chemistry 1987;262(32):15618-23.
1987: Ward R Rice; Gary F Ross; F M Singleton; S Dingle; Jeffrey A Whitsett
Surfactant-associated protein inhibits phospholipid secretion from type II cells.
Journal of applied physiology (Bethesda, Md. : 1985) 1987;63(2):692-8.
1987: M J McMahan; F Mimouni; M Miodovnik; William M Hull; Jeffrey A Whitsett
Surfactant associated protein (SAP-35) in amniotic fluid from diabetic and nondiabetic pregnancies.
Obstetrics and gynecology 1987;70(1):94-8.
1987: Stephan W Glasser; Thomas R Korfhagen; T Weaver; T Pilot-Matias; J L Fox; Jeffrey A Whitsett
cDNA and deduced amino acid sequence of human pulmonary surfactant-associated proteolipid SPL(Phe).
Proceedings of the National Academy of Sciences of the United States of America 1987;84(12):4007-11.
1987: Jeffrey A Whitsett
Molecular approaches to study of surfactant protein structure and function.
Mead Johnson Symposium on Perinatal and Developmental Medicine 1987;(29):35-9.
1985: Timothy E Weaver; William M Hull; Gary F Ross; Jeffrey A Whitsett
Intracellular and oligomeric forms of surfactant-associated apolipoproteins(s) A in the rat.
Biochimica et biophysica acta 1985;827(3):260-7.