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Lindsay Whitton

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Nadine Althof; J Lindsay Whitton
Coxsackievirus B3 infects the bone marrow and diminishes the restorative capacity of erythroid and lymphoid progenitors.
Christopher C Kemball; Jason Botten; Claudia T Flynn; Martin P Hosking; J Lindsay Whitton
Wild-type coxsackievirus infection dramatically alters the abundance, heterogeneity, and immunostimulatory capacity of conventional dendritic cells in vivo.
mehrdad alirezaei; Claudia T Flynn; J Lindsay Whitton
Interactions between enteroviruses and autophagy in vivo.

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All Publications

2013: Nadine Althof; J Lindsay Whitton
Coxsackievirus B3 infects the bone marrow and diminishes the restorative capacity of erythroid and lymphoid progenitors.
Journal of virology 2013;87(5):2823-34.
2012: Christopher C Kemball; Jason Botten; Claudia T Flynn; Martin P Hosking; J Lindsay Whitton
Wild-type coxsackievirus infection dramatically alters the abundance, heterogeneity, and immunostimulatory capacity of conventional dendritic cells in vivo.
Virology 2012;429(1):74-90.
2012: mehrdad alirezaei; Claudia T Flynn; J Lindsay Whitton
Interactions between enteroviruses and autophagy in vivo.
Autophagy 2012;8(6):973-5.
2012: mehrdad alirezaei; Claudia T Flynn; Malcolm R Wood; J Lindsay Whitton
Pancreatic acinar cell-specific autophagy disruption reduces coxsackievirus replication and pathogenesis in vivo.
Cell host & microbe 2012;11(3):298-305.
2012: Chelsea M Ruller; Mark A Sussman; Jenna M Tabor-Godwin; Donn A Van Deren; J Lindsay Whitton; Paul E Gilbert; Shea Gluhm; Natalie A Gude; Sonia Maciejewski; Scott M Robinson; Naili An; Ralph Feuer
Neural stem cell depletion and CNS developmental defects after enteroviral infection.
The American journal of pathology 2012;180(3):1107-20.
2011: Stephen J Crocker; Ricardo F Frausto; C S Moore; Robb R Pagarigan; R Bajpai; G D Brown; J Lindsay Whitton; Alexey V Terskikh
Intravenous administration of human embryonic stem cell-derived neural precursor cells attenuates cuprizone-induced central nervous system (CNS) demyelination.
Neuropathology and applied neurobiology 2011;37(6):643-53.
2011: Ginger Tsueng; Jenna M Tabor-Godwin; Aparajita Gopal; Chelsea M Ruller; Steven Deline; Naili An; Ricardo F Frausto; Richard Milner; Stephen J Crocker; J Lindsay Whitton; Ralph Feuer
Coxsackievirus preferentially replicates and induces cytopathic effects in undifferentiated neural progenitor cells.
Journal of virology 2011;85(12):5718-32.
2011: Craig S Moore; Richard Milner; Akiko Nishiyama; Ricardo F Frausto; David R Serwanski; Roberto R Pagarigan; J Lindsay Whitton; Robert H Miller; Stephen J Crocker
Astrocytic tissue inhibitor of metalloproteinase-1 (TIMP-1) promotes oligodendrocyte differentiation and enhances CNS myelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(16):6247-54.
2010: Christopher C Kemball; mehrdad alirezaei; Claudia T Flynn; Malcolm R Wood; Stephanie Harkins; William B Kiosses; J Lindsay Whitton
Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo.
Journal of virology 2010;84(23):12110-24.
2010: Jason Botten; J Lindsay Whitton; Polly Barrowman; John Sidney; Jason K Whitmire; Jeff Alexander; Maya F Kotturi; Alessandro Sette; Michael J Buchmeier
A multivalent vaccination strategy for the prevention of Old World arenavirus infection in humans.
Journal of virology 2010;84(19):9947-56.
2010: Christopher C Kemball; mehrdad alirezaei; J Lindsay Whitton
Type B coxsackieviruses and their interactions with the innate and adaptive immune systems.
Future microbiology 2010;5(9):1329-47.
2010: mehrdad alirezaei; Christopher C Kemball; Claudia T Flynn; Malcolm R Wood; J Lindsay Whitton; William B Kiosses
Short-term fasting induces profound neuronal autophagy.
Autophagy 2010;6(6):702-10.
2010: Jenna M Tabor-Godwin; Chelsea M Ruller; Nolan Bagalso; Naili An; Robb R Pagarigan; Stephanie Harkins; Paul E Gilbert; William B Kiosses; Natalie A Gude; Christopher T Cornell; Kelly S Doran; Mark A Sussman; J Lindsay Whitton; Ralph Feuer
A novel population of myeloid cells responding to coxsackievirus infection assists in the dissemination of virus within the neonatal CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(25):8676-91.
2009: Christopher C Kemball; Stephanie Harkins; Jason K Whitmire; Claudia T Flynn; Ralph Feuer; J Lindsay Whitton
Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway.
PLoS pathogens 2009;5(10):e1000618.
2009: Ralph Feuer; Chelsea M Ruller; Naili An; Jenna M Tabor-Godwin; Ross E Rhoades; Sonia Maciejewski; Robb R Pagarigan; Christopher T Cornell; Stephen J Crocker; William B Kiosses; Ngan Pham-Mitchell; Iain L Campbell; J Lindsay Whitton
Viral persistence and chronic immunopathology in the adult central nervous system following Coxsackievirus infection during the neonatal period.
Journal of virology 2009;83(18):9356-69.
2009: Jason K Whitmire; Boreth Eam; J Lindsay Whitton
Mice deficient in stem cell antigen-1 (Sca1, Ly-6A/E) develop normal primary and memory CD4+ and CD8+ T-cell responses to virus infection.
European journal of immunology 2009;39(6):1494-504.
2009: mehrdad alirezaei; Howard S Fox; Claudia T Flynn; Craig S Moore; Andrea L O Hebb; Ricardo F Frausto; Virender Bhan; William B Kiosses; J Lindsay Whitton; George S Robertson; Stephen J Crocker
Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis.
Autophagy 2009;5(2):152-8.
2008: DJ Theil; Jane E Libbey; Fernando Rodriguez; J Lindsay Whitton; Ikuo Tsunoda; Tobias J Derfuss; Robert S Fujinami
Targeting myelin proteolipid protein to the MHC class I pathway by ubiquitination modulates the course of experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 2008;204(1-2):92-100.
2008: Stephen J Crocker; Ricardo F Frausto; J Lindsay Whitton; Richard Milner
A novel method to establish microglia-free astrocyte cultures: comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia.
Glia 2008;56(11):1187-98.
2008: Paul Krogstad; Rebecca Hammon; Nancy Halnon; J Lindsay Whitton
Fatal neonatal myocarditis caused by a recombinant human enterovirus-B variant.
The Pediatric infectious disease journal 2008;27(7):668-9.
2008: Jason K Whitmire; Nicola Benning; Boreth Eam; J Lindsay Whitton
Increasing the CD4+ T cell precursor frequency leads to competition for IFN-gamma thereby degrading memory cell quantity and quality.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6777-85.
2008: Christopher C Kemball; Stephanie Harkins; J Lindsay Whitton
Enumeration and functional evaluation of virus-specific CD4+ and CD8+ T cells in lymphoid and peripheral sites of coxsackievirus B3 infection.
Journal of virology 2008;82(9):4331-42.
2008: Jason K Whitmire; Boreth Eam; J Lindsay Whitton
Tentative T cells: memory cells are quick to respond, but slow to divide.
PLoS pathogens 2008;4(4):e1000041.
2007: Stephen J Crocker; Ricardo F Frausto; Jason K Whitmire; Nicola Benning; Richard Milner; J Lindsay Whitton
Amelioration of coxsackievirus B3-mediated myocarditis by inhibition of tissue inhibitors of matrix metalloproteinase-1.
The American journal of pathology 2007;171(6):1762-73.
2007: Ricardo F Frausto; Stephen J Crocker; Boreth Eam; Jason K Whitmire; J Lindsay Whitton
Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency.
Journal of neuroimmunology 2007;192(1-2):124-33.
2007: Barbara Foster; Calman Prussin; Fei Liu; Jason K Whitmire; J Lindsay Whitton
Detection of intracellular cytokines by flow cytometry.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2007;Chapter 6():Unit 6.24.
2007: Jason K Whitmire; Boreth Eam; Nicola Benning; J Lindsay Whitton
Direct interferon-gamma signaling dramatically enhances CD4+ and CD8+ T cell memory.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1190-7.
2007: Christopher T Cornell; William B Kiosses; Stephanie Harkins; J Lindsay Whitton
Coxsackievirus B3 proteins directionally complement each other to downregulate surface major histocompatibility complex class I.
Journal of virology 2007;81(13):6785-97.
2007: Isabelle P Hunziker; Christopher T Cornell; J Lindsay Whitton
Deletions within the 5'UTR of coxsackievirus B3: consequences for virus translation and replication.
Virology 2007;360(1):120-8.
2007: Jason Botten; J Lindsay Whitton; Polly Barrowman; John Sidney; Jason K Whitmire; Jeff Alexander; Joey P C Ting; Huynh-Hoa Bui; Alessandro Sette; Michael J Buchmeier
HLA-A2-restricted protection against lethal lymphocytic choriomeningitis.
Journal of virology 2007;81(5):2307-17.
2007: Jane E Libbey; Ikuo Tsunoda; J Lindsay Whitton; Robert S Fujinami
Infectious RNA isolated from the spinal cords of mice chronically infected with Theiler's murine encephalomyelitis virus.
Journal of virology 2007;81(6):3009-11.
2006: Stephen J Crocker; Jason K Whitmire; Ricardo F Frausto; Parntip Chertboonmuang; Paul D Soloway; J Lindsay Whitton; Iain L Campbell
Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice.
The American journal of pathology 2006;169(6):2104-16.
2006: Natalia Fernandez-Borges; Alejandro Brun; J Lindsay Whitton; Beatriz Parra; Fayna Diaz-San Segundo; Francisco J Salguero; Juan M Torres; Fernando Rodriguez
DNA vaccination can break immunological tolerance to PrP in wild-type mice and attenuates prion disease after intracerebral challenge.
Journal of virology 2006;80(20):9970-6.
2006: Jason Botten; Jeff Alexander; Valerie Pasquetto; John Sidney; Polly Barrowman; Joey Ting; Bjoern Peters; Scott Southwood; Barbara Stewart; Maria P Rodriguez-Carreno; Bianca R Mothe; J Lindsay Whitton; Alessandro Sette; Michael J Buchmeier
Identification of protective Lassa virus epitopes that are restricted by HLA-A2.
Journal of virology 2006;80(17):8351-61.
2006: Christopher T Cornell; William B Kiosses; Stephanie Harkins; J Lindsay Whitton
Inhibition of protein trafficking by coxsackievirus b3: multiple viral proteins target a single organelle.
Journal of virology 2006;80(13):6637-47.
2006: Jason K Whitmire; Nicola Benning; J Lindsay Whitton
Precursor frequency, nonlinear proliferation, and functional maturation of virus-specific CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):3028-36.
2006: Fei Liu; Ralph Feuer; Daniel Hassett; J Lindsay Whitton
Peptide vaccination of mice immune to LCMV or vaccinia virus causes serious CD8 T cell-mediated, TNF-dependent immunopathology.
The Journal of clinical investigation 2006;116(2):465-75.
2006: Robert S Fujinami; Matthias G von Herrath; Urs Christen; J Lindsay Whitton
Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease.
Clinical microbiology reviews 2006;19(1):80-94.
2005: Jason K Whitmire; Nicola Benning; J Lindsay Whitton
Cutting edge: early IFN-gamma signaling directly enhances primary antiviral CD4+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5624-8.
2005: J Lindsay Whitton; Christopher T Cornell; Ralph Feuer
Host and virus determinants of picornavirus pathogenesis and tropism.
Nature reviews. Microbiology 2005;3(10):765-76.
2005: Alexander K Nussbaum; Maria P Rodriguez-Carreno; Nicola Benning; Jason Botten; J Lindsay Whitton
Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):1153-60.
2005: Fei Liu; J Lindsay Whitton
Cutting edge: re-evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):5936-40.
2005: Maria P Rodriguez-Carreno; Michael S Nelson; Jason Botten; Kim Smith-Nixon; Michael J Buchmeier; J Lindsay Whitton
Evaluating the immunogenicity and protective efficacy of a DNA vaccine encoding Lassa virus nucleoprotein.
Virology 2005;335(1):87-98.
2005: Jason K Whitmire; Joyce T Tan; J Lindsay Whitton
Interferon-gamma acts directly on CD8+ T cells to increase their abundance during virus infection.
The Journal of experimental medicine 2005;201(7):1053-9.
2005: Ralph Feuer; Robb R Pagarigan; Stephanie Harkins; Fei Liu; Isabelle P Hunziker; J Lindsay Whitton
Coxsackievirus targets proliferating neuronal progenitor cells in the neonatal CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(9):2434-44.
2005: Stephanie Harkins; Christopher T Cornell; J Lindsay Whitton
Analysis of translational initiation in coxsackievirus B3 suggests an alternative explanation for the high frequency of R+4 in the eukaryotic consensus motif.
Journal of virology 2005;79(2):987-96.
2004: Isabelle P Hunziker; Stephanie Harkins; Ralph Feuer; Christopher T Cornell; J Lindsay Whitton
Generation and analysis of an RNA vaccine that protects against coxsackievirus B3 challenge.
Virology 2004;330(1):196-208.
2004: Alexander K Nussbaum; J Lindsay Whitton
The contraction phase of virus-specific CD8+ T cells is unaffected by a pan-caspase inhibitor.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6611-8.
2004: J Lindsay Whitton; Ralph Feuer
Myocarditis, microbes and autoimmunity.
Autoimmunity 2004;37(5):375-86.
2004: Fei Liu; J Lindsay Whitton; Mark K Slifka
The rapidity with which virus-specific CD8+ T cells initiate IFN-gamma synthesis increases markedly over the course of infection and correlates with immunodominance.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):456-62.
2004: Jens A Leifert; Maria P Rodriguez-Carreno; Fernando Rodriguez; J Lindsay Whitton
Targeting plasmid-encoded proteins to the antigen presentation pathways.
Immunological reviews 2004;199():40-53.
2004: Ralph Feuer; Ignacio Mena; Robb R Pagarigan; Daniel Hassett; J Lindsay Whitton
Coxsackievirus replication and the cell cycle: a potential regulatory mechanism for viral persistence/latency.
Medical microbiology and immunology 2004;193(2-3):83-90.
2004: J Lindsay Whitton; Mark K Slifka; Fei Liu; Alexander K Nussbaum; Jason K Whitmire
The regulation and maturation of antiviral immune responses.
Advances in virus research 2004;63():181-238.
2003: Jens A Leifert; Phillip D Holler; Stephanie Harkins; David M Kranz; J Lindsay Whitton
The cationic region from HIV tat enhances the cell-surface expression of epitope/MHC class I complexes.
Gene therapy 2003;10(25):2067-73.
2003: Matthias G von Herrath; Robert S Fujinami; J Lindsay Whitton
Microorganisms and autoimmunity: making the barren field fertile?
Nature reviews. Microbiology 2003;1(2):151-7.
2003: Ralph Feuer; Ignacio Mena; Robb R Pagarigan; Stephanie Harkins; Daniel Hassett; J Lindsay Whitton
Coxsackievirus B3 and the neonatal CNS: the roles of stem cells, developing neurons, and apoptosis in infection, viral dissemination, and disease.
The American journal of pathology 2003;163(4):1379-93.
2003: Jens A Leifert; J Lindsay Whitton
"Translocatory proteins" and "protein transduction domains": a critical analysis of their biological effects and the underlying mechanisms.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(1):13-20.
2002: Jie Zhang; Nicole Silvestri; J Lindsay Whitton; Daniel Hassett
Neonates mount robust and protective adult-like CD8(+)-T-cell responses to DNA vaccines.
Journal of virology 2002;76(23):11911-9.
2002: J Lindsay Whitton
Infectious origins for chronic diseases.
MLO: medical laboratory observer 2002;34(11):10-5; quiz 16, 19.
2002: Jens A Leifert; Stephanie Harkins; J Lindsay Whitton
Full-length proteins attached to the HIV tat protein transduction domain are neither transduced between cells, nor exhibit enhanced immunogenicity.
Gene therapy 2002;9(21):1422-8.
2002: Ralph Feuer; Ignacio Mena; Robb R Pagarigan; Mark K Slifka; J Lindsay Whitton
Cell cycle status affects coxsackievirus replication, persistence, and reactivation in vitro.
Journal of virology 2002;76(9):4430-40.
2002: Fernando Rodriguez; Stephanie Harkins; Mark K Slifka; J Lindsay Whitton
Immunodominance in virus-induced CD8(+) T-cell responses is dramatically modified by DNA immunization and is regulated by gamma interferon.
Journal of virology 2002;76(9):4251-9.
2002: Laurie E Harrington; Robbert van der Most Rv; J Lindsay Whitton; Rafi Ahmed
Recombinant vaccinia virus-induced T-cell immunity: quantitation of the response to the virus vector and the foreign epitope.
Journal of virology 2002;76(7):3329-37.
2002: J Lindsay Whitton
Immunopathology during coxsackievirus infection.
Springer seminars in immunopathology 2002;24(2):201-13.
2002: J Lindsay Whitton
Designing arenaviral vaccines.
Current topics in microbiology and immunology 2002;263():221-38.
2001: Fernando Rodriguez; Stephanie Harkins; JM Redwine; Jose M de Pereda; J Lindsay Whitton
CD4(+) T cells induced by a DNA vaccine: immunological consequences of epitope-specific lysosomal targeting.
Journal of virology 2001;75(21):10421-30.
2001: Jens A Leifert; Jan Alvar Lindencrona; Jehad Charo; J Lindsay Whitton
Enhancing T cell activation and antiviral protection by introducing the HIV-1 protein transduction domain into a DNA vaccine.
Human gene therapy 2001;12(15):1881-92.
2001: Mark K Slifka; J Lindsay Whitton
Functional avidity maturation of CD8(+) T cells without selection of higher affinity TCR.
Nature immunology 2001;2(8):711-7.
2001: Fernando Rodriguez; Mark K Slifka; Stephanie Harkins; J Lindsay Whitton
Two overlapping subdominant epitopes identified by DNA immunization induce protective CD8(+) T-cell populations with differing cytolytic activities.
Journal of virology 2001;75(16):7399-409.
2001: DJ Theil; Ikuo Tsunoda; F Rodriguez; J Lindsay Whitton; Robert S Fujinami
Viruses can silently prime for and trigger central nervous system autoimmune disease.
Journal of neurovirology 2001;7(3):220-7.
2001: Matthias von Herrath; J Lindsay Whitton
Animal models using lymphocytic choriomeningitis virus.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 19():Unit 19.10.
2001: Mark K Slifka; Robb R Pagarigan; Ignacio Mena; Ralph Feuer; J Lindsay Whitton
Using recombinant coxsackievirus B3 to evaluate the induction and protective efficacy of CD8+ T cells during picornavirus infection.
Journal of virology 2001;75(5):2377-87.
2001: J Lindsay Whitton; R S Fujinami
DNA immunization and central nervous system viral infection.
Advances in virus research 2001;56():243-73.
2000: Daniel Hassett; Mark K Slifka; Jie Zhang; J Lindsay Whitton
Direct ex vivo kinetic and phenotypic analyses of CD8(+) T-cell responses induced by DNA immunization.
Journal of virology 2000;74(18):8286-91.
2000: Ignacio Mena; C Fischer; JR Gebhard; CM Perry; Stephanie Harkins; J Lindsay Whitton
Coxsackievirus infection of the pancreas: evaluation of receptor expression, pathogenesis, and immunopathology.
Virology 2000;271(2):276-88.
2000: Ling Ling An; Fernando Rodriguez; Stephanie Harkins; Jie Zhang; J Lindsay Whitton
Quantitative and qualitative analyses of the immune responses induced by a multivalent minigene DNA vaccine.
Vaccine 2000;18(20):2132-41.
2000: Noemí Sevilla; Dirk Homann; Matthias von Herrath; Fernando Rodriguez; Stephanie Harkins; J Lindsay Whitton; Michael B A Oldstone
Virus-induced diabetes in a transgenic model: role of cross-reacting viruses and quantitation of effector T cells needed to cause disease.
Journal of virology 2000;74(7):3284-92.
2000: F Rodriguez; J Lindsay Whitton
Enhancing DNA immunization.
Virology 2000;268(2):233-8.
2000: Daniel Hassett; Jie Zhang; Mark K Slifka; J Lindsay Whitton
Immune responses following neonatal DNA vaccination are long-lived, abundant, and qualitatively similar to those induced by conventional immunization.
Journal of virology 2000;74(6):2620-7.
2000: Mark K Slifka; Robb R Pagarigan; J Lindsay Whitton
NK markers are expressed on a high percentage of virus-specific CD8+ and CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):2009-15.
2000: Mark K Slifka; J Lindsay Whitton
Activated and memory CD8+ T cells can be distinguished by their cytokine profiles and phenotypic markers.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):208-16.
1999: Daniel Hassett; Jie Zhang; J Lindsay Whitton
Plasmid DNA vaccines are effective in the absence of IFNgamma.
Virology 1999;263(1):175-83.
1999: Ignacio Mena; CM Perry; Stephanie Harkins; Fernando Rodriguez; JR Gebhard; J Lindsay Whitton
The role of B lymphocytes in coxsackievirus B3 infection.
The American journal of pathology 1999;155(4):1205-15.
1999: Mark K Slifka; Fernando Rodriguez; J Lindsay Whitton
Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells.
Nature 1999;401(6748):76-9.
1999: Daniel Hassett; Jie Zhang; J Lindsay Whitton
Induction of antiviral antibodies by DNA immunization requires neither perforin-mediated nor CD8(+)-T-cell-mediated lysis of antigen-expressing cells.
Journal of virology 1999;73(9):7870-3.
1999: J Lindsay Whitton; R S Fujinami
Viruses as triggers of autoimmunity: facts and fantasies.
Current opinion in microbiology 1999;2(4):392-7.
1999: Ikuo Tsunoda; Neal D Tolley; DJ Theil; J Lindsay Whitton; H Kobayashi; Robert S Fujinami
Exacerbation of viral and autoimmune animal models for multiple sclerosis by bacterial DNA.
Brain pathology (Zurich, Switzerland) 1999;9(3):481-93.
1999: Bryan Coon; Ling Ling An; J Lindsay Whitton; Matthias G von Herrath
DNA immunization to prevent autoimmune diabetes.
The Journal of clinical investigation 1999;104(2):189-94.
1999: L Y Wang; DJ Theil; J Lindsay Whitton; Robert S Fujinami
Infection with a recombinant vaccinia virus encoding myelin proteolipid protein causes suppression of chronic relapsing-remitting experimental allergic encephalomyelitis.
Journal of neuroimmunology 1999;96(2):148-57.
1999: Michael B A Oldstone; Matthias von Herrath; Hanna Lewicki; Denis Hudrisier; J Lindsay Whitton; Jean Edouard Gairin
Use of a high-affinity peptide that aborts MHC-restricted cytotoxic T lymphocyte activity against multiple viruses in vitro and virus-induced immunopathologic disease in vivo.
Virology 1999;256(2):246-57.
1999: J Lindsay Whitton; Fernando Rodriguez; Jie Zhang; Daniel Hassett
DNA immunization: mechanistic studies.
Vaccine 1999;17(13-14):1612-9.
1999: Ling Ling An; J Lindsay Whitton
Multivalent minigene vaccines against infectious disease.
Current opinion in molecular therapeutics 1999;1(1):16-21.
1998: Yvette Akwa; Daniel Hassett; Maija-Leena Eloranta; K Sandberg; Eliezer Masliah; H Powell; J Lindsay Whitton; F E Bloom; Iain L Campbell
Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):5016-26.
1998: Ikuo Tsunoda; Li-Qing Kuang; Neal D Tolley; J Lindsay Whitton; Robert S Fujinami
Enhancement of experimental allergic encephalomyelitis (EAE) by DNA immunization with myelin proteolipid protein (PLP) plasmid DNA.
Journal of neuropathology and experimental neurology 1998;57(8):758-67.
1998: JR Gebhard; CM Perry; Stephanie Harkins; T Lane; Ignacio Mena; Valérie C Asensio; Iain L Campbell; J Lindsay Whitton
Coxsackievirus B3-induced myocarditis: perforin exacerbates disease, but plays no detectable role in virus clearance.
The American journal of pathology 1998;153(2):417-28.
1998: Fernando Rodriguez; Ling Ling An; Stephanie Harkins; Jie Zhang; M Yokoyama; Georg Widera; James T Fuller; Carrie Kincaid; Iain L Campbell; J Lindsay Whitton
DNA immunization with minigenes: low frequency of memory cytotoxic T lymphocytes and inefficient antiviral protection are rectified by ubiquitination.
Journal of virology 1998;72(6):5174-81.
1998: J Lindsay Whitton
An overview of antigen presentation and its central role in the immune response.
Current topics in microbiology and immunology 1998;232():1-13.
1997: Fernando Rodriguez; Jie Zhang; J Lindsay Whitton
DNA immunization: ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction.
Journal of virology 1997;71(11):8497-503.
1997: Daniel Hassett; Jie Zhang; J Lindsay Whitton
Neonatal DNA immunization with a plasmid encoding an internal viral protein is effective in the presence of maternal antibodies and protects against subsequent viral challenge.
Journal of virology 1997;71(10):7881-8.
1997: M Yokoyama; Daniel Hassett; Jie Zhang; J Lindsay Whitton
DNA immunization can stimulate florid local inflammation, and the antiviral immunity induced varies depending on injection site.
Vaccine 1997;15(5):553-60.
1997: Ling Ling An; J Lindsay Whitton
A multivalent minigene vaccine, containing B-cell, cytotoxic T-lymphocyte, and Th epitopes from several microbes, induces appropriate responses in vivo and confers protection against more than one pathogen.
Journal of virology 1997;71(3):2292-302.
1997: JR Gebhard; CM Perry; S Mahadeviah; J Lindsay Whitton
Use of a nonviral vector to express a chimeric tRNA-ribozyme against lymphocytic choriomeningitis virus: cytoplasmic accumulation of a catalytically competent transcript but minimal antiviral effect.
Antisense & nucleic acid drug development 1997;7(1):3-11.
1996: J Lindsay Whitton; M Yokoyama
Proteins expressed by DNA vaccines induce both local and systemic immune responses.
Annals of the New York Academy of Sciences 1996;797():196-206.
1996: D Hildeman; Maria Salvato; J Lindsay Whitton; D Muller
Vaccination protects beta 2 microglobulin deficient mice from immune mediated mortality but not from persisting viral infection.
Vaccine 1996;14(13):1223-9.
1996: Daniel Hassett; J Lindsay Whitton
DNA immunization.
Trends in microbiology 1996;4(8):307-12.
1996: M Yokoyama; Jie Zhang; J Lindsay Whitton
DNA immunization: effects of vehicle and route of administration on the induction of protective antiviral immunity.
FEMS immunology and medical microbiology 1996;14(4):221-30.
1996: Ling Ling An; Eric G Pamer; J Lindsay Whitton
A recombinant minigene vaccine containing a nonameric cytotoxic-T-lymphocyte epitope confers limited protection against Listeria monocytogenes infection.
Infection and immunity 1996;64(5):1685-93.
1996: L A Barnett; J Lindsay Whitton; L Y Wang; Robert S Fujinami
Virus encoding an encephalitogenic peptide protects mice from experimental allergic encephalomyelitis.
Journal of neuroimmunology 1996;64(2):163-73.
1996: M G von Herrath; M Yokoyama; J Dockter; Michael B A Oldstone; J Lindsay Whitton
CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge.
Journal of virology 1996;70(2):1072-9.
1995: Andreas Henke; S Huber; Axel Stelzner; J Lindsay Whitton
The role of CD8+ T lymphocytes in coxsackievirus B3-induced myocarditis.
Journal of virology 1995;69(11):6720-8.
1995: Hanna Lewicki; M G Von Herrath; Claire F Evans; J Lindsay Whitton; Michael B A Oldstone
CTL escape viral variants. II. Biologic activity in vivo.
Virology 1995;211(2):443-50.
1995: M Yokoyama; Jie Zhang; J Lindsay Whitton
DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection.
Journal of virology 1995;69(4):2684-8.
1995: Z Xing; S Mahadeviah; J Lindsay Whitton
Antiviral activity of RNA molecules containing self-releasing ribozymes targeted to lymphocytic choriomeningitis virus.
Antisense research and development 1995;5(3):203-12.
1995: J Lindsay Whitton; Jie Zhang
Principles of cytotoxic T lymphocyte induction and recognition.
Current topics in microbiology and immunology 1995;202():247-59.
1994: J Lindsay Whitton
Induction of protective immunity using minigenes.
Annals of the New York Academy of Sciences 1994;730():107-17.
1994: K Sandberg; P Kemper; AK Stalder; Jie Zhang; Monte V Hobbs; J Lindsay Whitton; Iain L Campbell
Altered tissue distribution of viral replication and T cell spreading is pivotal in the protection against fatal lymphocytic choriomeningitis in mice after neutralization of IFN-alpha/beta.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(1):220-31.
1994: Peter C Doherty; S Hou; Claire F Evans; J Lindsay Whitton; Michael B A Oldstone; Marcia A Blackman
Limiting the available T cell receptor repertoire modifies acute lymphocytic choriomeningitis virus-induced immunopathology.
Journal of neuroimmunology 1994;51(2):147-52.
1994: J Lindsay Whitton
Antisense treatment of viral infection.
Advances in virus research 1994;44():267-303.
1993: L A Barnett; J Lindsay Whitton; Y Wada; Robert S Fujinami
Enhancement of autoimmune disease using recombinant vaccinia virus encoding myelin proteolipid protein.
Journal of neuroimmunology 1993;48(1):120.
1993: Michael B A Oldstone; Antoinette Tishon; M Eddleston; Juan Carlos de la Torre; T McKee; J Lindsay Whitton
Vaccination to prevent persistent viral infection.
Journal of virology 1993;67(7):4372-8.
1993: N Sheng; J Zhang; J Lindsay Whitton; T McKee
A rapid and simple method for determining the DNA sequences of fragments inserted into vaccinia virus.
BioTechniques 1993;14(5):781-4.
1993: Z Xing; J Lindsay Whitton
An anti-lymphocytic choriomeningitis virus ribozyme expressed in tissue culture cells diminishes viral RNA levels and leads to a reduction in infectious virus yield.
Journal of virology 1993;67(4):1840-7.
1993: L A Barnett; J Lindsay Whitton; Y Wada; Robert S Fujinami
Enhancement of autoimmune disease using recombinant vaccinia virus encoding myelin proteolipid protein.
Journal of neuroimmunology 1993;44(1):15-25.
1993: J Lindsay Whitton; N Sheng; Michael B A Oldstone; T A McKee
A "string-of-beads" vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge.
Journal of virology 1993;67(1):348-52.
1992: Hanna Lewicki; T A McKee; Antoinette Tishon; Maria Salvato; J Lindsay Whitton; Michael B A Oldstone
Novel LCMV-specific H-2k restricted CTL clones recognize internal viral gene products and cause CNS disease.
Journal of neuroimmunology 1992;41(1):15-20.
1992: Michael B A Oldstone; Antoinette Tishon; R Geckeler; Hanna Lewicki; J Lindsay Whitton
A common antiviral cytotoxic T-lymphocyte epitope for diverse major histocompatibility complex haplotypes: implications for vaccination.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2752-5.
1992: Z Xing; J Lindsay Whitton
Ribozymes which cleave arenavirus RNAs: identification of susceptible target sites and inhibition by target site secondary structure.
Journal of virology 1992;66(3):1361-9.
1990: L S Klavinskis; J Lindsay Whitton; E Joly; M B Oldstone
Vaccination and protection from a lethal viral infection: identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope.
Virology 1990;178(2):393-400.
1989: L S Klavinskis; J Lindsay Whitton; M B Oldstone
Molecularly engineered vaccine which expresses an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection.
Journal of virology 1989;63(10):4311-6.
1989: J Lindsay Whitton; Antoinette Tishon; Hanna Lewicki; JR Gebhard; T Cook; Maria Salvato; E Joly; M B Oldstone
Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: an immunodominant region which induces nonreciprocal CTL cross-reactivity.
Journal of virology 1989;63(10):4303-10.
1989: E Joly; Maria Salvato; J Lindsay Whitton; M B Oldstone
Polymorphism of cytotoxic T-lymphocyte clones that recognize a defined nine-amino-acid immunodominant domain of lymphocytic choriomeningitis virus glycoprotein.
Journal of virology 1989;63(5):1845-51.
1988: M B Oldstone; J Lindsay Whitton; Hanna Lewicki; Antoinette Tishon
Fine dissection of a nine amino acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class I-restricted H-2Db cytotoxic T lymphocytes.
The Journal of experimental medicine 1988;168(2):559-70.
1988: J Lindsay Whitton; JR Gebhard; Hanna Lewicki; Antoinette Tishon; M B Oldstone
Molecular definition of a major cytotoxic T-lymphocyte epitope in the glycoprotein of lymphocytic choriomeningitis virus.
Journal of virology 1988;62(3):687-95.
1988: J Lindsay Whitton; P J Southern; M B Oldstone
Analyses of the cytotoxic T lymphocyte responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus.
Virology 1988;162(2):321-7.