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Linda Wicker

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Xiaotian Lin; Laurence B Peterson; Dan Rainbow; Jocelyn Cheung; Yang D Dai; Emma E Hamilton-Williams; Kara M Hunter; Linda S Wicker; Linda A Sherman
Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes.
Marcin Lukasz Pekalski; Deborah J Smyth; Helen E Stevens; John A Todd; Timothy I M Tree; Neil M Walker; Chris Wallace; Xaquin Castro Dopico; Gillian Coleman; Richard M R Coulson; Antony J Cutler; Calliope A Dendrou; Kate Downes; David B Dunger; L Esposito; Ricardo C Ferreira; Hui Guo; Catherine Guy; Sarah Nutland; Linda S Wicker
Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.
Kritika Kachapati; Robert S Mittler; Dan Rainbow; Charles A Steward; Linda S Wicker; Yuehong Wu; David E Adams; William M Ridgway
The B10 Idd9.3 locus mediates accumulation of functionally superior CD137(+) regulatory T cells in the nonobese diabetic type 1 diabetes model.

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All Publications

2013: Xiaotian Lin; Laurence B Peterson; Dan Rainbow; Jocelyn Cheung; Yang D Dai; Emma E Hamilton-Williams; Kara M Hunter; Linda S Wicker; Linda A Sherman
Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(7):3109-20.
2013: Marcin Lukasz Pekalski; Deborah J Smyth; Helen E Stevens; John A Todd; Timothy I M Tree; Neil M Walker; Chris Wallace; Xaquin Castro Dopico; Gillian Coleman; Richard M R Coulson; Antony J Cutler; Calliope A Dendrou; Kate Downes; David B Dunger; L Esposito; Ricardo C Ferreira; Hui Guo; Catherine Guy; Sarah Nutland; Linda S Wicker
Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(6):2554-66.
2012: Kritika Kachapati; Robert S Mittler; Dan Rainbow; Charles A Steward; Linda S Wicker; Yuehong Wu; David E Adams; William M Ridgway
The B10 Idd9.3 locus mediates accumulation of functionally superior CD137(+) regulatory T cells in the nonobese diabetic type 1 diabetes model.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(10):5001-15.
2012: Christian J Maine; Nunzio Bottini; Jocelyn Cheung; Emma E Hamilton-Williams; Stephanie M Stanford; Linda S Wicker; Linda A Sherman
PTPN22 alters the development of regulatory T cells in the thymus.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(11):5267-75.
2011: Javid P Mohammed; Carolyn Moule; Laurence B Peterson; Dan Rainbow; William M Ridgway; Paul B Savage; John A Todd; Linda S Wicker; MARSHA WILLS-KARP; Jan Clark; Heather I Fraser; Michael E Fusakio; Jochen Mattner
Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):337-49.
2011: Dan Rainbow; William M Ridgway; Charles A Steward; John A Todd; Jeffrey A Bluestone; Oliver Burren; Mikkel Christensen; Jan Clark; Erik B Finger; Heather I Fraser; Michael E Fusakio; J P Houchins; Sarah Howlett; Frank Koentgen; Emma L Masteller; Jochen Mattner; Javid P Mohammed; Val Moody; Carolyn Moule; Dieter Naf; Laurence B Peterson; Linda S Wicker
Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):325-36.
2010: Emma E Hamilton-Williams; S B Justin Wong; Xavier Martinez; Daniel B Rainbow; Kara M Hunter; Linda S Wicker; Linda A Sherman
Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells.
Diabetes 2010;59(6):1478-86.
2010: Erik Fung; Laura Esposito; John A Todd; Linda S Wicker
Multiplexed immunophenotyping of human antigen-presenting cells in whole blood by polychromatic flow cytometry.
Nature protocols 2010;5(2):357-70.
2010: Jun Yamanouchi; Maria-Carmen Puertas; Joan Verdaguer; Paul A Lyons; Dan Rainbow; Giselle Chamberlain; Kara M Hunter; Laurence B Peterson; Linda S Wicker; Pere Santamaria
Idd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ regulatory T-cells.
Diabetes 2010;59(1):272-81.
2009: Jinguo Wang; Linda S Wicker; Pere Santamaria
IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunity.
Seminars in immunology 2009;21(6):363-71.
2009: Emma E Hamilton-Williams; Xavier Martinez; Jan Clark; Sarah Howlett; Kara M Hunter; Daniel B Rainbow; Li Wen; Mark J Shlomchik; Jonathan D Katz; Georg F Beilhack; Linda S Wicker; Linda A Sherman
Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1533-41.
2009: E Y M G Fung; Deborah J Smyth; Joanna M M Howson; Jason D Cooper; Neil M Walker; Helen Stevens; Linda S Wicker; John A Todd
Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.
Genes and immunity 2009;10(2):188-91.
2009: Calliope A Dendrou; Erik Fung; L Esposito; John A Todd; Linda S Wicker; Vincent Plagnol
Fluorescence intensity normalisation: correcting for time effects in large-scale flow cytometric analysis.
Advances in bioinformatics 2009;():476106.
2009: Lisa M Maier; Christopher E Lowe; Jason Cooper; Kate Downes; David E Anderson; Christopher Severson; Pamela M Clark; Brian Healy; Neil Walker; Cristin Aubin; Jorge R Oksenberg; Stephen L Hauser; Alistair Compston; Stephen Sawcer; Philip De Jager; Linda S Wicker; John A Todd; David A Hafler
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.
PLoS genetics 2009;5(1):e1000322.
2009: Julie Mangada; Todd Pearson; Michael A Brehm; Linda S Wicker; Laurence B Peterson; Leonard D Shultz; David V Serreze; Aldo A Rossini; Dale L Greiner
Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.
Diabetes 2009;58(1):165-73.
2009: J P Hafler; Lisa M Maier; Jason D Cooper; Vincent Plagnol; A Hinks; M J Simmonds; Helen E Stevens; Neil M Walker; Barry Healy; Joanna M M Howson; M Maisuria; S Duley; G Coleman; S C L Gough; J Worthington; V K Kuchroo; Linda S Wicker; John A Todd
CD226 Gly307Ser association with multiple autoimmune diseases.
Genes and immunity 2009;10(1):5-10.
2008: Lisa M Maier; Sarah Howlett; Kara M Rainbow; Jan Clark; Joanna M M Howson; John A Todd; Linda S Wicker
NKG2D-RAE-1 receptor-ligand variation does not account for the NK cell defect in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):7073-80.
2008: Calliope A Dendrou; Linda S Wicker
The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice.
Journal of clinical immunology 2008;28(6):685-96.
2008: Dan B Rainbow; Laura Esposito; Sarah Howlett; Kara M Hunter; John A Todd; Laurence B Peterson; Linda S Wicker
Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species.
Biochemical Society transactions 2008;36(Pt 3):312-5.
2008: Junichiro Irie; Brian Reck; Yuehong Wu; Linda S Wicker; Sarah Howlett; Dan Rainbow; Eleanor Feingold; William M Ridgway
Genome-wide microarray expression analysis of CD4+ T Cells from nonobese diabetic congenic mice identifies Cd55 (Daf1) and Acadl as candidate genes for type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):1071-9.
2008: William M Ridgway; Laurence B Peterson; John A Todd; Dan Rainbow; Barry Healy; Oliver S Burren; Linda S Wicker
Gene-gene interactions in the NOD mouse model of type 1 diabetes.
Advances in immunology 2008;100():151-75.
2007: Kara Hunter; Dan Rainbow; Vincent Plagnol; John A Todd; Laurence B Peterson; Linda S Wicker
Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(12):8341-9.
2007: Lisa M Maier; David E Anderson; Philip De Jager; Linda S Wicker; David A Hafler
Allelic variant in CTLA4 alters T cell phosphorylation patterns.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(47):18607-12.
2007: Christopher E Lowe; Jason D Cooper; Todd Brusko; Neil M Walker; Deborah J Smyth; Rebecca Bailey; Kirsi Bourget; Vincent Plagnol; Sarah Field; Mark Atkinson; David G Clayton; Linda S Wicker; John A Todd
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.
Nature genetics 2007;39(9):1074-82.
2007: William M Ridgway; Barry Healy; Luc J Smink; Dan Rainbow; Linda S Wicker
New tools for defining the 'genetic background' of inbred mouse strains.
Nature immunology 2007;8(7):669-73.
2007: Joanna M M Howson; David D Dunger; Sarah Nutland; Helen Stevens; Linda S Wicker; John A Todd
A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene.
Diabetologia 2007;50(4):741-6.
2007: Jun Yamanouchi; Dan Rainbow; Pau Serra; Sarah Howlett; Kara Hunter; Valerie E S Garner; Andrea Gonzalez-Munoz; Jan Clark; Riitta Veijola; Rose Cubbon; Show-Ling Chen; Raymond Rosa; Anne Marie Cumiskey; David V Serreze; Simon Gregory; Jane Rogers; Paul A Lyons; Barry Healy; Luc J Smink; John A Todd; Laurence B Peterson; Linda S Wicker; Pere Santamaria
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
Nature genetics 2007;39(3):329-37.
2007: Erin M Hulbert; Luc J Smink; Ellen C Adlem; James E Allen; David B Burdick; Oliver Burren; Victor M Cassen; Christopher C Cavnor; Geoffrey E Dolman; Daisy Flamez; Karen F Friery; Barry C Healy; Sarah A Killcoyne; Burak Kutlu; Helen Schuilenburg; Neil M Walker; Josyf C Mychaleckyj; Decio L Eizirik; Linda S Wicker; John A Todd; Nathan Goodman
T1DBase: integration and presentation of complex data for type 1 diabetes research.
Nucleic acids research 2007;35(Database issue):D742-6.
2006: Giselle Chamberlain; Maja Wållberg; Dan Rainbow; Kara Hunter; Linda S Wicker; E Allison Green
A 20-Mb region of chromosome 4 controls TNF-alpha-mediated CD8+ T cell aggression toward beta cells in type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5105-14.
2006: Junichiro Irie; Yuehong Wu; Linda S Wicker; Dan Rainbow; Michael A Nalesnik; Raphael Hirsch; Laurence B Peterson; Patrick S C Leung; Chunmei Cheng; Ian R Mackay; M Eric Gershwin; William M Ridgway
NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis.
The Journal of experimental medicine 2006;203(5):1209-19.
2006: Stephan Kissler; Patrick Stern; Kazue Takahashi; Kara Hunter; Laurence B Peterson; Linda S Wicker
In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes.
Nature genetics 2006;38(4):479-83.
2006: Hidenori Taniguchi; Christopher E Lowe; Jason D Cooper; Deborah J Smyth; Rebecca Bailey; Sarah Nutland; Barry C Healy; Alex C Lam; Oliver Burren; Neil M Walker; Luc J Smink; Linda S Wicker; John A Todd
Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes.
BMC genetics 2006;7():22.
2005: Lisa M Maier; Linda S Wicker
Genetic susceptibility to type 1 diabetes.
Current opinion in immunology 2005;17(6):601-8.
2005: Jennifer L Cannons; Giselle Chamberlain; Joanna M M Howson; Luc J Smink; John A Todd; Laurence B Peterson; Linda S Wicker; Tania H Watts
Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetes.
Journal of autoimmunity 2005;25(1):13-20.
2005: Linda S Wicker; Jan Clark; Heather I Fraser; Valerie E S Garner; Andrea Gonzalez-Munoz; Barry Healy; Sarah Howlett; Kara Hunter; Dan Rainbow; Raymond L Rosa; Luc J Smink; John A Todd; Laurence B Peterson
Type 1 diabetes genes and pathways shared by humans and NOD mice.
Journal of autoimmunity 2005;25 Suppl():29-33.
2005: Lalitha Vijayakrishnan; Jacqueline Slavik; Zsolt Illés; Dan Rainbow; Laurence B Peterson; Arlene S Sharpe; Linda S Wicker; Vijay K Kuchroo
An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in T cells.
Novartis Foundation symposium 2005;267():200-12; discussion 212-8.
2005: Linda S Wicker; Carolyn Moule; Heather Fraser; Carlos Penha-Goncalves; Dan Rainbow; Valerie E S Garner; Giselle Chamberlain; Kara Hunter; Sarah Howlett; Jan Clark; Andrea Gonzalez-Munoz; Anne Marie Cumiskey; Paul Tiffen; Joanna M M Howson; Barry Healy; Luc J Smink; Amanda Kingsnorth; Paul A Lyons; Simon Gregory; Jane Rogers; John A Todd; Laurence B Peterson
Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse.
Novartis Foundation symposium 2005;267():57-65; discussion 65-75.
2005: Lisa M Maier; Deborah J Smyth; Adrian Vella; Felicity Payne; Jason D Cooper; Rebecca Pask; Christopher Lowe; John S Hulme; Luc J Smink; Heather Fraser; Carolyn Moule; Kara M Hunter; Giselle Chamberlain; Neil Walker; Sarah Nutland; DAG UNDLIEN; Kjersti S Rønningen; Cristian Guja; Constantin Ionescu-Tîrgoviste; David A Savage; David P Strachan; Laurence B Peterson; John A Todd; Linda S Wicker; Rebecca C J Twells
Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes.
BMC genetics 2005;6():9.
2005: Ethel J Gordon; Linda S Wicker; Laurence B Peterson; David V Serreze; Thomas G Markees; Leonard D Shultz; Aldo A Rossini; Dale L Greiner; John P Mordes
Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.
Diabetes 2005;54(1):107-15.
2005: Luc J Smink; Erin M Helton; Barry C Healy; Christopher C Cavnor; Alex C Lam; Daisy Flamez; Oliver Burren; Yang Wang; Geoffrey E Dolman; David B Burdick; Vincent H Everett; Gustavo Glusman; Davide Laneri; Lee Rowen; Helen Schuilenburg; Neil M Walker; Josyf C Mychaleckyj; Linda S Wicker; Decio L Eizirik; John A Todd; Nathan Goodman
T1DBase, a community web-based resource for type 1 diabetes research.
Nucleic acids research 2005;33(Database issue):D544-9.
2004: Linda S Wicker; Laurence B Peterson
Immune-based disease: complex genetics meets immunology.
Immunity 2004;21(6):743.
2004: Syuichi Koarada; Yuehong Wu; Noreen Fertig; David A Sass; Michael A Nalesnik; John A Todd; Paul A Lyons; Judith Fenyk-Melody; Dan Rainbow; Linda S Wicker; Laurence B Peterson; William M Ridgway
Genetic control of autoimmunity: protection from diabetes, but spontaneous autoimmune biliary disease in a nonobese diabetic congenic strain.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2315-23.
2004: Todd Pearson; Peter Weiser; Thomas G Markees; David V Serreze; Linda S Wicker; Laurence B Peterson; Anne-Marie Cumisky; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.
Diabetes 2004;53(8):1972-8.
2004: Linda S Wicker; Giselle Chamberlain; Kara Hunter; Dan Rainbow; Sarah Howlett; Paul Tiffen; Jan Clark; Andrea Gonzalez-Munoz; Anne Marie Cumiskey; Raymond L Rosa; Joanna M M Howson; Luc J Smink; Amanda Kingsnorth; Paul A Lyons; Simon Gregory; Jane Rogers; John A Todd; Laurence B Peterson
Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):164-73.
2004: Bernhard Greve; Lalitha Vijayakrishnan; Aarup Kubal; Raymond A Sobel; Laurence B Peterson; Linda S Wicker; Vijay K Kuchroo
The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):157-63.
2004: Lalitha Vijayakrishnan; Jacqueline Slavik; Zsolt Illés; Rebecca J Greenwald; Dan Rainbow; Bernhard Greve; Laurence B Peterson; David A Hafler; Gordon J Freeman; Arlene H Sharpe; Linda S Wicker; Vijay K Kuchroo
An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells.
Immunity 2004;20(5):563-75.
2004: Oliver Burren; Barry C Healy; Alex C Lam; Helen Schuilenburg; Geoffrey E Dolman; Vincent H Everett; Davide Laneri; Sarah Nutland; Helen E Rance; Felicity Payne; Deborah Smyth; Chris Lowe; Bryan J Barratt; Rebecca C J Twells; Dan Rainbow; Linda S Wicker; John A Todd; Neil M Walker; Luc J Smink
Development of an integrated genome informatics, data management and workflow infrastructure: a toolbox for the study of complex disease genetics.
Human genomics 2004;1(2):98-109.
2003: Todd Pearson; Thomas G Markees; David V Serreze; Melissa A Pierce; Linda S Wicker; Laurence B Peterson; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?
Annals of the New York Academy of Sciences 2003;1005():148-56.
2003: Todd Pearson; Thomas G Markees; David V Serreze; Melissa A Pierce; Linda S Wicker; Laurence B Peterson; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.
Reviews in endocrine & metabolic disorders 2003;4(3):255-61.
2003: Todd Pearson; Thomas G Markees; David V Serreze; Melissa A Pierce; Michele P Marron; Linda S Wicker; Laurence B Peterson; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):185-95.
2003: Jenny H Xie; Naomi Nomura; Min Lu; Shiow-Ling Chen; Greg E Koch; Youmin Weng; Raymond Rosa; Jerry Di Salvo; John S Mudgett; Laurence B Peterson; Linda S Wicker; Julie A DeMartino
Antibody-mediated blockade of the CXCR3 chemokine receptor results in diminished recruitment of T helper 1 cells into sites of inflammation.
Journal of leukocyte biology 2003;73(6):771-80.
2003: Carlos Penha-Gonçalves; Carolyn Moule; Luc J Smink; Joanna M M Howson; Simon Gregory; Jane Rogers; Paul A Lyons; Joseph J Suttie; christopher Lord; Laurence B Peterson; John A Todd; Linda S Wicker
Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice.
Diabetes 2003;52(6):1551-6.
2003: David T Robles; George S Eisenbarth; Natalie J M Dailey; Laurence B Peterson; Linda S Wicker
Insulin autoantibodies are associated with islet inflammation but not always related to diabetes progression in NOD congenic mice.
Diabetes 2003;52(3):882-6.
2003: Todd Pearson; Thomas G Markees; Linda S Wicker; David V Serreze; Laurence B Peterson; John P Mordes; Aldo A Rossini; Dale L Greiner
NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction.
Diabetes 2003;52(2):321-6.
2003: Frances A Brook; Edward P Evans; christopher Lord; Paul A Lyons; Dan Rainbow; Sarah K Howlett; Linda S Wicker; John A Todd; Richard L Gardner
The derivation of highly germline-competent embryonic stem cells containing NOD-derived genome.
Diabetes 2003;52(1):205-8.
2002: James E Thompson; Rose M Cubbon; Richard T Cummings; Linda S Wicker; Robert Frankshun; Barry R Cunningham; Patricia M Cameron; Peter T Meinke; Nigel J Liverton; Youmin Weng; Julie A DeMartino
Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor.
Bioorganic & medicinal chemistry letters 2002;12(8):1219-23.
2002: Iain A Eaves; Linda S Wicker; Ghassan Ghandour; Paul A Lyons; Laurence B Peterson; John A Todd; Richard J Glynne
Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: the NOD model of type 1 diabetes.
Genome research 2002;12(2):232-43.
2001: Paul A Lyons; N Armitage; christopher Lord; Michael S Phillips; John A Todd; Laurence B Peterson; Linda S Wicker
Mapping by genetic interaction: high-resolution congenic mapping of the type 1 diabetes loci Idd10 and Idd18 in the NOD mouse.
Diabetes 2001;50(11):2633-7.
2001: John A Todd; Linda S Wicker
Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models.
Immunity 2001;15(3):387-95.
2001: christopher Lord; Sarah Howlett; Paul A Lyons; Laurence B Peterson; Linda S Wicker; John A Todd
The murine type 1 diabetes loci, Idd1, Idd3, Idd5, Idd9, and Idd17/10/18, do not control thymic CD4-CD8-/TCRalphabeta+ deficiency in the nonobese diabetic mouse.
Mammalian genome : official journal of the International Mammalian Genome Society 2001;12(2):175-6.
2000: NJ Hill; Paul A Lyons; N Armitage; John A Todd; Linda S Wicker; Laurence B Peterson
NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.
Diabetes 2000;49(10):1744-7.
2000: T Siegmund; N Armitage; Linda S Wicker; Laurence B Peterson; John A Todd; Paul A Lyons
Analysis of the mouse CD30 gene: a candidate for the NOD mouse type 1 diabetes locus Idd9.2.
Diabetes 2000;49(9):1612-6.
2000: Paul A Lyons; W W Hancock; Paul Denny; christopher Lord; NJ Hill; N Armitage; T Siegmund; John A Todd; Michael S Phillips; J Fred Hess; S L Chen; P A Fischer; Laurence B Peterson; Linda S Wicker
The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137.
Immunity 2000;13(1):107-15.
2000: PL Podolin; MB Wilusz; Rose M Cubbon; U Pajvani; christopher Lord; John A Todd; Laurence B Peterson; Linda S Wicker; Paul A Lyons
Differential glycosylation of interleukin 2, the molecular basis for the NOD Idd3 type 1 diabetes gene?
Cytokine 2000;12(5):477-82.
2000: Paul A Lyons; N Armitage; F Argentina; Paul Denny; NJ Hill; christopher Lord; MB Wilusz; Laurence B Peterson; Linda S Wicker; John A Todd
Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping.
Genome research 2000;10(4):446-53.
1999: C Ma; P E Whiteley; Patricia M Cameron; D C Freed; A Pressey; S L Chen; B Garni-Wagner; C Fang; Dennis Zaller; Linda S Wicker; Janice S Blum
Role of APC in the selection of immunodominant T cell epitopes.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6413-23.
1999: A Brian Jones; John J Acton; Alan D Adams; W Yuen; Elizabeth A Nichols; Cheryl D Schwartz; Linda S Wicker; Jeffrey Donald Hermes
Tetrapeptide derived inhibitors of complexation of a class II MHC: fully unnatural ligands.
Bioorganic & medicinal chemistry letters 1999;9(14):2115-8.
1999: A Brian Jones; John J Acton; M N Rivetna; Richard T Cummings; Rose M Cubbon; Elizabeth A Nichols; Cheryl D Schwartz; Linda S Wicker; Jeffrey Donald Hermes
Tetrapeptide derived inhibitors of complexation of a class II MHC: the peptide backbone is not inviolate.
Bioorganic & medicinal chemistry letters 1999;9(14):2109-14.
1999: J A Encinas; Linda S Wicker; Laurence B Peterson; A Mukasa; C Teuscher; R Sobel; Howard L Weiner; C E Seidman; J G Seidman; V K Kuchroo
QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2.
Nature genetics 1999;21(2):158-60.
1999: P A Lyons; Linda S Wicker
Localising quantitative trait loci in the NOD mouse model of type 1 diabetes.
Current directions in autoimmunity 1999;1():208-25.
1998: PL Podolin; Paul Denny; N Armitage; christopher Lord; NJ Hill; ER Levy; Laurence B Peterson; John A Todd; Linda S Wicker; Paul A Lyons
Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse chromosome 3.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(4):283-6.
1997: PL Podolin; Paul Denny; christopher Lord; NJ Hill; John A Todd; Laurence B Peterson; Linda S Wicker; Paul A Lyons
Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1835-43.
1997: Paul Denny; christopher Lord; NJ Hill; J V Goy; ER Levy; PL Podolin; Laurence B Peterson; Linda S Wicker; John A Todd; Paul A Lyons
Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene.
Diabetes 1997;46(4):695-700.
1996: Linda S Wicker; S L Chen; Gerald Nepom; John Elliott; D C Freed; A Bansal; S Zheng; A Herman; A Lernmark; Dennis Zaller; Laurence B Peterson; J B Rothbard; R Cummings; P J Whiteley
Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.
The Journal of clinical investigation 1996;98(11):2597-603.
1996: E Colomb; W Savino; Linda S Wicker; L Peterson; M Dardenne; Claude Carnaud
Genetic control of giant perivascular space formation in the thymus of NOD mice.
Diabetes 1996;45(11):1535-40.
1996: M S Lee; R Mueller; Linda S Wicker; Laurence B Peterson; Nora Sarvetnick
IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity.
The Journal of experimental medicine 1996;183(6):2663-8.
1995: christopher Lord; S K Bohlander; E A Hopes; Montague Carl; NJ Hill; Johannes B Prins; R J Renjilian; Laurence B Peterson; Linda S Wicker; John A Todd
Mapping the diabetes polygene Idd3 on mouse chromosome 3 by use of novel congenic strains.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(9):563-70.
1995: Linda S Wicker; J A Todd; Laurence B Peterson
Genetic control of autoimmune diabetes in the NOD mouse.
Annual review of immunology 1995;13():179-200.
1994: Linda S Wicker; John A Todd; J B Prins; PL Podolin; R J Renjilian; Laurence B Peterson
Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes.
The Journal of experimental medicine 1994;180(5):1705-13.
1994: E E Powell; Linda S Wicker; Laurence B Peterson; John A Todd
Allelic variation of the type 2 tumor necrosis factor receptor gene.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(11):726-7.
1994: S L Chen; P J Whiteley; D C Freed; J B Rothbard; Laurence B Peterson; Linda S Wicker
Responses of NOD congenic mice to a glutamic acid decarboxylase-derived peptide.
Journal of autoimmunity 1994;7(5):635-41.
1994: C M Hill; A Liu; K W Marshall; J Mayer; B Jorgensen; B Yuan; R M Cubbon; Elizabeth A Nichols; Linda S Wicker; J B Rothbard
Exploration of requirements for peptide binding to HLA DRB1*0101 and DRB1*0401.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):2890-8.
1994: Linda S Wicker; E H Leiter; John A Todd; R J Renjilian; E Peterson; P A Fischer; PL Podolin; M Zijlstra; Rudolf Jaenisch; Laurence B Peterson
Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes.
Diabetes 1994;43(3):500-4.
1994: NR Rodrigues; Richard J Cornall; P Chandler; E Simpson; Linda S Wicker; Laurence B Peterson; John A Todd
Mapping of an insulin-dependent diabetes locus, Idd9, in NOD mice to chromosome 4.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(3):167-70.
1993: PL Podolin; A Pressey; N H DeLarato; P A Fischer; Laurence B Peterson; Linda S Wicker
I-E+ nonobese diabetic mice develop insulitis and diabetes.
The Journal of experimental medicine 1993;178(3):793-803.
1993: J B Prins; John A Todd; NR Rodrigues; S Ghosh; P M Hogarth; Linda S Wicker; E Gaffney; PL Podolin; P A Fischer; A Sirotina
Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice.
Science (New York, N.Y.) 1993;260(5108):695-8.
1992: Claude Carnaud; B Legrand; M Olivi; Laurence B Peterson; Linda S Wicker; Jean-François Bach
Acquired allo-tolerance to major or minor histocompatibility antigens indifferently contributes to preventing diabetes development in non-obese diabetic (NOD) mice.
Journal of autoimmunity 1992;5(5):591-601.
1992: Linda S Wicker; M C Appel; Francesco Dotta; A Pressey; B J Miller; N H DeLarato; P A Fischer; R C Boltz; Laurence B Peterson
Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes.
The Journal of experimental medicine 1992;176(1):67-77.
1992: Linda S Wicker; PL Podolin; P Fischer; A Sirotina; R C Boltz; Laurence B Peterson
Expression of intra-MHC transporter (Ham) genes and class I antigens in diabetes-susceptible NOD mice.
Science (New York, N.Y.) 1992;256(5065):1828-30; author reply 1830-1.
1992: M Nagata; Yoko Mullen; S Matsuo; Linda S Wicker; Laurence B Peterson
The impact of T cells in nonspecific destruction of beta cells in mice.
Transplantation proceedings 1992;24(3):988-9.
1991: S Matsuo; Yoko Mullen; Linda S Wicker; Laurence B Peterson; M Nagata
Islet destruction by the NOD mouse may be mediated by both MHC-restricted and nonrestricted mechanisms.
Transplantation proceedings 1991;23(1 Pt 1):743-4.
1990: Linda S Wicker; R C Boltz; V Matt; Elizabeth A Nichols; Laurence B Peterson; Nolan Sigal
Suppression of B cell activation by cyclosporin A, FK506 and rapamycin.
European journal of immunology 1990;20(10):2277-83.
1990: S Matsuo; Yoko Mullen; Linda S Wicker; Laurence B Peterson; M Nagata; T Tsunoda; Michael J Clare-Salzler
Prolongation of islet isograft survival in diabetic NOD mice by anti-L3T4 and anti-LYT2 monoclonal antibodies.
Transplantation proceedings 1990;22(2):880-1.
1989: L H Young; Laurence B Peterson; Linda S Wicker; Pedro Persechini; J D Young
In vivo expression of perforin by CD8+ lymphocytes in autoimmune disease. Studies on spontaneous and adoptively transferred diabetes in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(12):3994-9.
1989: Linda S Wicker; B J Miller; P A Fischer; A Pressey; Laurence B Peterson
Genetic control of diabetes and insulitis in the nonobese diabetic mouse. Pedigree analysis of a diabetic H-2nod/b heterozygote.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(3):781-4.
1988: Linda S Wicker; B J Miller; A Chai; M Terada; Yoko Mullen
Expression of genetically determined diabetes and insulitis in the nonobese diabetic (NOD) mouse at the level of bone marrow-derived cells. Transfer of diabetes and insulitis to nondiabetic (NOD X B10) F1 mice with bone marrow cells from NOD mice.
The Journal of experimental medicine 1988;167(6):1801-10.
1988: Gloria C Koo; M E Jewell; C L Manyak; Nolan Sigal; Linda S Wicker
Activation of murine natural killer cells and macrophages by 8-bromoguanosine.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(9):3249-52.
1988: Linda S Wicker; W T Ashton; R C Boltz; L C Meurer; B J Miller; Elizabeth A Nichols; Nolan Sigal; Richard L Tolman; Laurence B Peterson
5-Halo-6-phenyl pyrimidinones and 8-substituted guanosines: biological response modifiers with similar effects on B cells.
Cellular immunology 1988;112(1):156-65.
1988: B J Miller; M C Appel; J J O'Neil; Linda S Wicker
Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(1):52-8.
1987: Linda S Wicker; B J Miller; L Z Coker; S E McNally; S Scott; Y Mullen; M C Appel
Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse.
The Journal of experimental medicine 1987;165(6):1639-54.
1987: Linda S Wicker; R C Boltz; Elizabeth A Nichols; B J Miller; Nolan Sigal; Laurence B Peterson
Large, activated B cells are the primary B-cell target of 8-bromoguanosine and 8-mercaptoguanosine.
Cellular immunology 1987;106(2):318-29.