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William Wickner

Research Profile

Anatomy

Vacuoles

Physiology

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Protein Binding

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Publications

TOP 3
Hao Xu; Michael Zick; William Wickner; Youngsoo Jun
A lipid-anchored SNARE supports membrane fusion.
William Wickner; Teresa Garrett; Carlos B Hirschberg; JoAnne Stubbe; William Dowhan
Chris Raetz, scientist and enduring friend.
Hao Xu; William Wickner
Phosphoinositides function asymmetrically for membrane fusion, promoting tethering and 3Q-SNARE subcomplex assembly.

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All Publications

2011: Hao Xu; Michael Zick; William Wickner; Youngsoo Jun
A lipid-anchored SNARE supports membrane fusion.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(42):17325-30.
2011: William Wickner; Teresa Garrett; Carlos B Hirschberg; JoAnne Stubbe; William Dowhan
Chris Raetz, scientist and enduring friend.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(42):17255-6.
2010: Hao Xu; William Wickner
Phosphoinositides function asymmetrically for membrane fusion, promoting tethering and 3Q-SNARE subcomplex assembly.
The Journal of biological chemistry 2010;285(50):39359-65.
2010: Christopher Hickey; William Wickner
HOPS initiates vacuole docking by tethering membranes before trans-SNARE complex assembly.
Molecular biology of the cell 2010;21(13):2297-305.
2010: Hao Xu; youngsoo jun; James Thompson; John Yates; William Wickner
HOPS prevents the disassembly of trans-SNARE complexes by Sec17p/Sec18p during membrane fusion.
The EMBO journal 2010;29(12):1948-60.
2010: William Wickner
Membrane fusion: five lipids, four SNAREs, three chaperones, two nucleotides, and a Rab, all dancing in a ring on yeast vacuoles.
Annual review of cell and developmental biology 2010;26():115-36.
2009: Christopher Stroupe; Christopher Hickey; Joji Mima; Amy S Burfeind; William Wickner
Minimal membrane docking requirements revealed by reconstitution of Rab GTPase-dependent membrane fusion from purified components.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17626-33.
2009: Joji Mima; William Wickner
Complex lipid requirements for SNARE- and SNARE chaperone-dependent membrane fusion.
The Journal of biological chemistry 2009;284(40):27114-22.
2009: Joji Mima; William Wickner
Phosphoinositides and SNARE chaperones synergistically assemble and remodel SNARE complexes for membrane fusion.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16191-6.
2009: Christopher Hickey; Christopher Stroupe; William Wickner
The major role of the Rab Ypt7p in vacuole fusion is supporting HOPS membrane association.
The Journal of biological chemistry 2009;284(24):16118-25.
2008: Joji Mima; Christopher Hickey; Hao Xu; youngsoo jun; William Wickner
Reconstituted membrane fusion requires regulatory lipids, SNAREs and synergistic SNARE chaperones.
The EMBO journal 2008;27(15):2031-42.
2008: William Wickner; Randy Schekman
Membrane fusion.
Nature structural & molecular biology 2008;15(7):658-64.
2008: Vincent Starai; Christopher Hickey; William Wickner
HOPS proofreads the trans-SNARE complex for yeast vacuole fusion.
Molecular biology of the cell 2008;19(6):2500-8.
2007: youngsoo jun; Hao Xu; Naomi Thorngren; William Wickner
Sec18p and Vam7p remodel trans-SNARE complexes to permit a lipid-anchored R-SNARE to support yeast vacuole fusion.
The EMBO journal 2007;26(24):4935-45.
2007: Vincent Starai; youngsoo jun; William Wickner
Excess vacuolar SNAREs drive lysis and Rab bypass fusion.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(34):13551-8.
2007: youngsoo jun; William Wickner
Assays of vacuole fusion resolve the stages of docking, lipid mixing, and content mixing.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):13010-5.
2007: Kevin M Collins; William Wickner
Trans-SNARE complex assembly and yeast vacuole membrane fusion.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8755-60.
2007: Rutilio A Fratti; Kevin M Collins; Christopher Hickey; William Wickner
Stringent 3Q.1R composition of the SNARE 0-layer can be bypassed for fusion by compensatory SNARE mutation or by lipid bilayer modification.
The Journal of biological chemistry 2007;282(20):14861-7.
2007: Rutilio A Fratti; William Wickner
Distinct targeting and fusion functions of the PX and SNARE domains of yeast vacuolar Vam7p.
The Journal of biological chemistry 2007;282(17):13133-8.
2006: youngsoo jun; Naomi Thorngren; Vincent Starai; Rutilio A Fratti; Kevin Collins; William Wickner
Reversible, cooperative reactions of yeast vacuole docking.
The EMBO journal 2006;25(22):5260-9.
2006: Hao Xu; William Wickner
Bem1p is a positive regulator of the homotypic fusion of yeast vacuoles.
The Journal of biological chemistry 2006;281(37):27158-66.
2006: Bridget L Decker; William Wickner
Enolase activates homotypic vacuole fusion and protein transport to the vacuole in yeast.
The Journal of biological chemistry 2006;281(20):14523-8.
2006: Christopher Stroupe; Kevin M Collins; Rutilio A Fratti; William Wickner
Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p.
The EMBO journal 2006;25(8):1579-89.
2005: William Wickner; Randy Schekman
Protein translocation across biological membranes.
Science (New York, N.Y.) 2005;310(5753):1452-6.
2005: Kevin M Collins; Naomi Thorngren; Rutilio A Fratti; William Wickner
Sec17p and HOPS, in distinct SNARE complexes, mediate SNARE complex disruption or assembly for fusion.
The EMBO journal 2005;24(10):1775-86.
2005: Vincent Starai; Naomi Thorngren; Rutilio A Fratti; William Wickner
Ion regulation of homotypic vacuole fusion in Saccharomyces cerevisiae.
The Journal of biological chemistry 2005;280(17):16754-62.
2004: Rutilio A Fratti; youngsoo jun; Alexey J Merz; Nathan Margolis; William Wickner
Interdependent assembly of specific regulatory lipids and membrane fusion proteins into the vertex ring domain of docked vacuoles.
The Journal of cell biology 2004;167(6):1087-98.
2004: youngsoo jun; Rutilio A Fratti; William Wickner
Diacylglycerol and its formation by phospholipase C regulate Rab- and SNARE-dependent yeast vacuole fusion.
The Journal of biological chemistry 2004;279(51):53186-95.
2004: Alexey J Merz; William Wickner
Resolution of organelle docking and fusion kinetics in a cell-free assay.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11548-53.
2004: Naomi Thorngren; Kevin M Collins; Rutilio A Fratti; William Wickner; Alexey J Merz
A soluble SNARE drives rapid docking, bypassing ATP and Sec17/18p for vacuole fusion.
The EMBO journal 2004;23(14):2765-76.
2004: Alexey J Merz; William Wickner
Trans-SNARE interactions elicit Ca2+ efflux from the yeast vacuole lumen.
The Journal of cell biology 2004;164(2):195-206.
2003: Masashi Kato; William Wickner
Vam10p defines a Sec18p-independent step of priming that allows yeast vacuole tethering.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6398-403.
2003: Li Wang; Alexey J Merz; Kevin M Collins; William Wickner
Hierarchy of protein assembly at the vertex ring domain for yeast vacuole docking and fusion.
The Journal of cell biology 2003;160(3):365-74.
2002: Gary Eitzen; Li Wang; Naomi Thorngren; William Wickner
Remodeling of organelle-bound actin is required for yeast vacuole fusion.
The Journal of cell biology 2002;158(4):669-79.
2002: William Wickner
Yeast vacuoles and membrane fusion pathways.
The EMBO journal 2002;21(6):1241-7.
2002: E Scott Seeley; Masashi Kato; Nathan Margolis; William Wickner; Gary Eitzen
Genomic analysis of homotypic vacuole fusion.
Molecular biology of the cell 2002;13(3):782-94.
2002: Li Wang; E Scott Seeley; William Wickner; Alexey J Merz
Vacuole fusion at a ring of vertex docking sites leaves membrane fragments within the organelle.
Cell 2002;108(3):357-69.
2001: Gary Eitzen; Naomi Thorngren; William Wickner
Rho1p and Cdc42p act after Ypt7p to regulate vacuole docking.
The EMBO journal 2001;20(20):5650-6.
2001: Masashi Kato; William Wickner
Ergosterol is required for the Sec18/ATP-dependent priming step of homotypic vacuole fusion.
The EMBO journal 2001;20(15):4035-40.
2001: TL Yahr; William Wickner
Functional reconstitution of bacterial Tat translocation in vitro.
The EMBO journal 2001;20(10):2472-9.
2000: Gary Eitzen; E Will; Dieter Gallwitz; A Haas; William Wickner
Sequential action of two GTPases to promote vacuole docking and fusion.
The EMBO journal 2000;19(24):6713-20.
2000: D F Seals; Gary Eitzen; Nathan Margolis; William Wickner; A Price
A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9402-7.
2000: TL Yahr; William Wickner
Evaluating the oligomeric state of SecYEG in preprotein translocase.
The EMBO journal 2000;19(16):4393-401.
2000: C Ungermann; A Price; William Wickner
A new role for a SNARE protein as a regulator of the Ypt7/Rab-dependent stage of docking.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):8889-91.
2000: L Wang; C Ungermann; William Wickner
The docking of primed vacuoles can be reversibly arrested by excess Sec17p (alpha-SNAP).
The Journal of biological chemistry 2000;275(30):22862-7.
2000: A Price; D Seals; William Wickner; C Ungermann
The docking stage of yeast vacuole fusion requires the transfer of proteins from a cis-SNARE complex to a Rab/Ypt protein.
The Journal of cell biology 2000;148(6):1231-8.
2000: A Price; William Wickner; C Ungermann
Proteins needed for vesicle budding from the Golgi complex are also required for the docking step of homotypic vacuole fusion.
The Journal of cell biology 2000;148(6):1223-29.
2000: William Wickner; A Haas
Yeast homotypic vacuole fusion: a window on organelle trafficking mechanisms.
Annual review of biochemistry 2000;69():247-75.
1999: C Ungermann; William Wickner; Z Xu
Vacuole acidification is required for trans-SNARE pairing, LMA1 release, and homotypic fusion.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11194-9.
1999: C Ungermann; GF von Mollard; O N Jensen; Nathan Margolis; Tom H Stevens; William Wickner
Three v-SNAREs and two t-SNAREs, present in a pentameric cis-SNARE complex on isolated vacuoles, are essential for homotypic fusion.
The Journal of cell biology 1999;145(7):1435-42.
1999: Franck Duong; William Wickner
The PrlA and PrlG phenotypes are caused by a loosened association among the translocase SecYEG subunits.
The EMBO journal 1999;18(12):3263-70.
1998: C Ungermann; K Sato; William Wickner
Defining the functions of trans-SNARE pairs.
Nature 1998;396(6711):543-8.
1998: Jerry Eichler; William Wickner
The SecA subunit of Escherichia coli preprotein translocase is exposed to the periplasm.
Journal of bacteriology 1998;180(21):5776-9.
1998: Jerry Eichler; K Rinard; William Wickner
Endogenous SecA catalyzes preprotein translocation at SecYEG.
The Journal of biological chemistry 1998;273(34):21675-81.
1998: K Sato; William Wickner
Functional reconstitution of ypt7p GTPase and a purified vacuole SNARE complex.
Science (New York, N.Y.) 1998;281(5377):700-2.
1998: Z Xu; K Sato; William Wickner
LMA1 binds to vacuoles at Sec18p (NSF), transfers upon ATP hydrolysis to a t-SNARE (Vam3p) complex, and is released during fusion.
Cell 1998;93(7):1125-34.
1998: C Ungermann; William Wickner
Vam7p, a vacuolar SNAP-25 homolog, is required for SNARE complex integrity and vacuole docking and fusion.
The EMBO journal 1998;17(12):3269-76.
1998: Franck Duong; William Wickner
Sec-dependent membrane protein biogenesis: SecYEG, preprotein hydrophobicity and translocation kinetics control the stop-transfer function.
The EMBO journal 1998;17(3):696-705.
1998: C Ungermann; Benjamin J Nichols; Hugh R B Pelham; William Wickner
A vacuolar v-t-SNARE complex, the predominant form in vivo and on isolated vacuoles, is disassembled and activated for docking and fusion.
The Journal of cell biology 1998;140(1):61-9.
1997: Franck Duong; Jerry Eichler; A Price; M R Leonard; William Wickner
Biogenesis of the gram-negative bacterial envelope.
Cell 1997;91(5):567-73.
1997: Franck Duong; William Wickner
The SecDFyajC domain of preprotein translocase controls preprotein movement by regulating SecA membrane cycling.
The EMBO journal 1997;16(16):4871-9.
1997: P Slusarewicz; Z Xu; K Seefeld; A Haas; William Wickner
I2B is a small cytosolic protein that participates in vacuole fusion.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(11):5582-7.
1997: Jerry Eichler; William Wickner
Both an N-terminal 65-kDa domain and a C-terminal 30-kDa domain of SecA cycle into the membrane at SecYEG during translocation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(11):5574-81.
1997: Franck Duong; William Wickner
Distinct catalytic roles of the SecYE, SecG and SecDFyajC subunits of preprotein translocase holoenzyme.
The EMBO journal 1997;16(10):2756-68.
1997: Benjamin J Nichols; C Ungermann; Hugh R B Pelham; William Wickner; A Haas
Homotypic vacuolar fusion mediated by t- and v-SNAREs.
Nature 1997;387(6629):199-202.
1997: Jerry Eichler; J Brunner; William Wickner
The protease-protected 30 kDa domain of SecA is largely inaccessible to the membrane lipid phase.
The EMBO journal 1997;16(9):2188-96.
1997: A Mayer; William Wickner
Docking of yeast vacuoles is catalyzed by the Ras-like GTPase Ypt7p after symmetric priming by Sec18p (NSF).
The Journal of cell biology 1997;136(2):307-17.
1997: Z Xu; A Mayer; E Muller; William Wickner
A heterodimer of thioredoxin and I(B)2 cooperates with Sec18p (NSF) to promote yeast vacuole inheritance.
The Journal of cell biology 1997;136(2):299-306.
1996: A Price; A Economou; Franck Duong; William Wickner
Separable ATPase and membrane insertion domains of the SecA subunit of preprotein translocase.
The Journal of biological chemistry 1996;271(49):31580-4.
1996: William Wickner; M R Leonard
Escherichia coli preprotein translocase.
The Journal of biological chemistry 1996;271(47):29514-6.
1996: A Haas; William Wickner
Homotypic vacuole fusion requires Sec17p (yeast alpha-SNAP) and Sec18p (yeast NSF).
The EMBO journal 1996;15(13):3296-305.
1996: A Mayer; William Wickner; A Haas
Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles.
Cell 1996;85(1):83-94.
1996: Z Xu; William Wickner
Thioredoxin is required for vacuole inheritance in Saccharomyces cerevisiae.
The Journal of cell biology 1996;132(5):787-94.
1995: A Economou; J A Pogliano; Jonathan R. Beckwith; D B Oliver; William Wickner
SecA membrane cycling at SecYEG is driven by distinct ATP binding and hydrolysis events and is regulated by SecD and SecF.
Cell 1995;83(7):1171-81.
1995: A Haas; D Scheglmann; T Lazar; Dieter Gallwitz; William Wickner
The GTPase Ypt7p of Saccharomyces cerevisiae is required on both partner vacuoles for the homotypic fusion step of vacuole inheritance.
The EMBO journal 1995;14(21):5258-70.
1995: William Wickner
The nascent-polypeptide-associated complex: having a "NAC" for fidelity in translocation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9433-4.
1995: K Douville; A Price; Jerry Eichler; A Economou; William Wickner
SecYEG and SecA are the stoichiometric components of preprotein translocase.
The Journal of biological chemistry 1995;270(34):20106-11.
1995: William Wickner; M R Leonard; A Economou
On the road to translocase.
Cold Spring Harbor symposia on quantitative biology 1995;60():285-90.
1994: William Wickner
How ATP drives proteins across membranes.
Science (New York, N.Y.) 1994;266(5188):1197-8.
1994: A Economou; William Wickner
SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion.
Cell 1994;78(5):835-43.
1994: K Douville; M Leonard; L Brundage; K Nishiyama; H Tokuda; S Mizushima; William Wickner
Band 1 subunit of Escherichia coli preportein translocase and integral membrane export factor P12 are the same protein.
The Journal of biological chemistry 1994;269(29):18705-7.