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Norman Wideburg

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Publications

TOP 3
Xiaoqi Chen; Dale J Kempf; Lin Li; Hing L Sham; Sudthida Vasavanonda; Norman E Wideburg; Ayda Saldivar; Kennan Marsh; Edith McDonald; Daniel W Norbeck
Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands.
Xiaoqi Chen; Dale J Kempf; Hing L Sham; Brian E Green; Akhteruzzaman Molla; M Korneyeva; Sudthida Vasavanonda; Norman E Wideburg; Ayda Saldivar; Kennan Marsh; Edith McDonald; Daniel W Norbeck
Potent piperazine hydroxyethylamine HIV protease inhibitors containing novel P3 ligands.
Hing L Sham; Dale J Kempf; Akhteruzzaman Molla; Kennan Marsh; Gondi N Kumar; Chih-Ming Chen; Warren M Kati; K Stewart; R Lal; Ann Hsu; David A Betebenner; M Korneyeva; Sudthida Vasavanonda; Edith McDonald; Ayda Saldivar; Norman E Wideburg; Xiaoqi Chen; P Niu; Chang Park; Venkata K Jayanti; Brian A Grabowski; G Richard Granneman; Eugene Sun; Anthony J Japour; JM Leonard; Jacob J Plattner; Daniel W Norbeck
ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease.

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All Publications

2003: Xiaoqi Chen; Dale J Kempf; Lin Li; Hing L Sham; Sudthida Vasavanonda; Norman E Wideburg; Ayda Saldivar; Kennan Marsh; Edith McDonald; Daniel W Norbeck
Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands.
Bioorganic & medicinal chemistry letters 2003;13(21):3657-60.
1998: Xiaoqi Chen; Dale J Kempf; Hing L Sham; Brian E Green; Akhteruzzaman Molla; M Korneyeva; Sudthida Vasavanonda; Norman E Wideburg; Ayda Saldivar; Kennan Marsh; Edith McDonald; Daniel W Norbeck
Potent piperazine hydroxyethylamine HIV protease inhibitors containing novel P3 ligands.
Bioorganic & medicinal chemistry letters 1998;8(24):3531-6.
1998: Hing L Sham; Dale J Kempf; Akhteruzzaman Molla; Kennan Marsh; Gondi N Kumar; Chih-Ming Chen; Warren M Kati; K Stewart; R Lal; Ann Hsu; David A Betebenner; M Korneyeva; Sudthida Vasavanonda; Edith McDonald; Ayda Saldivar; Norman E Wideburg; Xiaoqi Chen; P Niu; Chang Park; Venkata K Jayanti; Brian A Grabowski; G Richard Granneman; Eugene Sun; Anthony J Japour; JM Leonard; Jacob J Plattner; Daniel W Norbeck
ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease.
Antimicrobial agents and chemotherapy 1998;42(12):3218-24.
1998: Dale J Kempf; Hing L Sham; Kennan Marsh; Charles A Flentge; David A Betebenner; Brian E Green; Edith McDonald; Sudthida Vasavanonda; Ayda Saldivar; Norman E Wideburg; Warren M Kati; L Ruiz; Chen Zhao; L Fino; J Patterson; Akhteruzzaman Molla; Jacob J Plattner; Daniel W Norbeck
Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy.
Journal of medicinal chemistry 1998;41(4):602-17.
1996: Hing L Sham; C Zhao; Kennan Marsh; David A Betebenner; S Lin; W Rosenbrook; T Herrin; L Li; D Madigan; Sudthida Vasavanonda; Akhteruzzaman Molla; Ayda Saldivar; Edith McDonald; Norman E Wideburg; Dale J Kempf; Daniel W Norbeck; Jacob J Plattner
Novel azacyclic ureas that are potent inhibitors of HIV-1 protease.
Biochemical and biophysical research communications 1996;225(2):436-40.
1996: Hing L Sham; C Zhao; Kent D Stewart; David A Betebenner; S Lin; C H Park; X P Kong; W Rosenbrook; T Herrin; D Madigan; Sudthida Vasavanonda; N Lyons; Akhteruzzaman Molla; Ayda Saldivar; Kennan Marsh; Edith McDonald; Norman E Wideburg; Jon F Denissen; T Robins; Dale J Kempf; Jacob J Plattner; Daniel W Norbeck
A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.
Journal of medicinal chemistry 1996;39(2):392-7.
1995: G T Wang; S Li; Norman E Wideburg; Grant A Krafft; Dale J Kempf
Synthetic chemical diversity: solid phase synthesis of libraries of C2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores.
Journal of medicinal chemistry 1995;38(16):2995-3002.
1995: Hing L Sham; C Zhao; Kennan Marsh; David A Betebenner; S Lin; Edith McDonald; Sudthida Vasavanonda; Norman E Wideburg; Ayda Saldivar; T Robins
Potent inhibitors of the HIV-1 protease with good oral bioavailabilities.
Biochemical and biophysical research communications 1995;211(1):159-65.
1994: Dale J Kempf; Kennan Marsh; L C Fino; P Bryant; A Craig-Kennard; Hing L Sham; C Zhao; Sudthida Vasavanonda; William Kohlbrenner; Norman E Wideburg
Design of orally bioavailable, symmetry-based inhibitors of HIV protease.
Bioorganic & medicinal chemistry 1994;2(9):847-58.
1994: David D Ho; T Toyoshima; H Mo; Dale J Kempf; Daniel W Norbeck; Chih-Ming Chen; Norman E Wideburg; S K Burt; John W Erickson; M K Singh
Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor.
Journal of virology 1994;68(3):2016-20.
1993: Hing L Sham; David A Betebenner; Norman E Wideburg; Ayda Saldivar; William Kohlbrenner; A Craig-Kennard; Sudthida Vasavanonda; Dale J Kempf; J J Clement; J E Erickson
Pseudo-symmetrical difluoroketones. Highly potent and specific inhibitors of HIV-1 protease.
FEBS letters 1993;329(1-2):144-6.
1993: Dale J Kempf; L Codacovi; X C Wang; William Kohlbrenner; Norman E Wideburg; Ayda Saldivar; Sudthida Vasavanonda; Kennan Marsh; P Bryant; Hing L Sham
Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol.
Journal of medicinal chemistry 1993;36(3):320-30.
1992: William Kohlbrenner; Norman E Wideburg; Weigl Debra; Ayda Saldivar; Daniel T Chu
Induction of calf thymus topoisomerase II-mediated DNA breakage by the antibacterial isothiazoloquinolones A-65281 and A-65282.
Antimicrobial agents and chemotherapy 1992;36(1):81-6.
1991: Hing L Sham; David A Betebenner; Norman E Wideburg; Ayda Saldivar; William Kohlbrenner; Sudthida Vasavanonda; Dale J Kempf; Daniel W Norbeck; C Zhao; J J Clement
Potent HIV-1 protease inhibitors with antiviral activities in vitro.
Biochemical and biophysical research communications 1991;175(3):914-9.
1990: Dale J Kempf; Daniel W Norbeck; L Codacovi; X C Wang; William Kohlbrenner; Norman E Wideburg; D A Paul; MF Knigge; Sudthida Vasavanonda; A Craig-Kennard
Structure-based, C2 symmetric inhibitors of HIV protease.
Journal of medicinal chemistry 1990;33(10):2687-9.
1990: J Erickson; D J Neidhart; J VanDrie; Dale J Kempf; X C Wang; Daniel W Norbeck; Jacob J Plattner; J W Rittenhouse; M Turon; Norman E Wideburg
Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease.
Science (New York, N.Y.) 1990;249(4968):527-33.