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Christian Widmann

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TOP 3
Christian Widmann
Genetics and molecular biology: HDL-endoplasmic reticulum connection and cholesterol sensor.
Hadi Khalil; Lucas Liaudet; Benjamin Marsland; Nieves Peltzer; Joël Walicki; Paul Bigliardi; Gilles Dubuis; Noémie Gardiol; Werner Held; Jiang-Yan Yang; Christian Widmann
Caspase-3 protects stressed organs against cell death.
Nieves Peltzer; Paul Bigliardi; Christian Widmann
UV-B induces cytoplasmic survivin expression in mouse epidermis.

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All Publications

2013: Christian Widmann
Genetics and molecular biology: HDL-endoplasmic reticulum connection and cholesterol sensor.
Current opinion in lipidology 2013;24(1):103-4.
2012: Hadi Khalil; Lucas Liaudet; Benjamin Marsland; Nieves Peltzer; Joël Walicki; Paul Bigliardi; Gilles Dubuis; Noémie Gardiol; Werner Held; Jiang-Yan Yang; Christian Widmann
Caspase-3 protects stressed organs against cell death.
Molecular and cellular biology 2012;32(22):4523-33.
2012: Nieves Peltzer; Paul Bigliardi; Christian Widmann
UV-B induces cytoplasmic survivin expression in mouse epidermis.
Journal of dermatological science 2012;67(3):196-9.
2012: Hadi Khalil; Lucas Liaudet; Nathalie Rosenblatt; Christian Widmann
The role of endogenous and exogenous RasGAP-derived fragment N in protecting cardiomyocytes from peroxynitrite-induced apoptosis.
Free radical biology & medicine 2012;53(4):926-35.
2012: Romano Regazzi; Christian Widmann
Genetics and molecular biology: miRNAs take the HDL ride.
Current opinion in lipidology 2012;23(2):165-6.
2011: Jannick Pétremand; Christian Widmann
Genetics and molecular biology: fatty acids and endoplasmic reticulum stress.
Current opinion in lipidology 2011;22(4):315-6.
2011: Natasa Bulat; Gilles Dubuis; Evrim Jaccard; Hadi Khalil; Nieves Peltzer; Jiang-Yan Yang; Christian Widmann
RasGAP-derived fragment N increases the resistance of beta cells towards apoptosis in NOD mice and delays the progression from mild to overt diabetes.
PloS one 2011;6(7):e22609.
2010: Jannick Pétremand; Christian Widmann
The HDL: adipocyte connection.
Current opinion in lipidology 2010;21(4):388-9.
2010: Alessandro Annibaldi; Christian Widmann
Glucose metabolism in cancer cells.
Current opinion in clinical nutrition and metabolic care 2010;13(4):466-70.
2009: Evrim Jaccard; Christian Widmann
ABC transporters: HDL-regulated gatekeepers at the endothelial border.
Current opinion in lipidology 2009;20(6):526-7.
2009: Jiang-Yan Yang; Joël Walicki; Evrim Jaccard; Gilles Dubuis; Natasa Bulat; Jean-Pierre Hornung; Bernard Thorens; Christian Widmann
Expression of the NH(2)-terminal fragment of RasGAP in pancreatic beta-cells increases their resistance to stresses and protects mice from diabetes.
Diabetes 2009;58(11):2596-606.
2009: Natasa Bulat; Christian Widmann
Caspase substrates and neurodegenerative diseases.
Brain research bulletin 2009;80(4-5):251-67.
2009: Jannick Pétremand; Natasa Bulat; Anne-Christine Butty; Carine Poussin; Sabine Rütti; Karin Au; Sujoy Ghosh; Vincent Mooser; Bernard Thorens; Jiang-Yan Yang; Christian Widmann; Gerard Waeber
Involvement of 4E-BP1 in the protection induced by HDLs on pancreatic beta-cells.
Molecular endocrinology (Baltimore, Md.) 2009;23(10):1572-86.
2009: Marion Cornu; Jiang-Yan Yang; Evrim Jaccard; Carine Poussin; Christian Widmann; Bernard Thorens
Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop.
Diabetes 2009;58(8):1816-25.
2009: Alessandro Annibaldi; David Michod; Linda Vanetta; Steeve Cruchet; Pascal Nicod; Gilles Dubuis; Christelle Bonvin; Christian Widmann
Role of the sub-cellular localization of RasGAP fragment N2 for its ability to sensitize cancer cells to genotoxin-induced apoptosis.
Experimental cell research 2009;315(12):2081-91.
2009: Valérie Plaisance; Véronique Perret; Dimitri Favre; Amar Abderrahmani; Jiang-Yan Yang; Christian Widmann; Romano Regazzi
Role of the transcriptional factor C/EBPbeta in free fatty acid-elicited beta-cell failure.
Molecular and cellular endocrinology 2009;305(1-2):47-55.
2009: David Michod; Alessandro Annibaldi; Stephan Schaefer; Christine Dapples; Bertrand Rochat; Christian Widmann
Effect of RasGAP N2 fragment-derived peptide on tumor growth in mice.
Journal of the National Cancer Institute 2009;101(11):828-32.
2009: Evrim Jaccard; Christian Widmann
Genetics and molecular biology: so, so complex HDLs!
Current opinion in lipidology 2009;20(3):254-5.
2008: Jannick Pétremand; Christian Widmann
Lipid metabolism: sphingolipids- from membrane constituents to signaling molecules that control cell-to-cell communications.
Current opinion in lipidology 2008;19(6):620-1.
2008: Natasa Bulat; Christian Widmann
Generation of a tightly regulated all-cis beta cell-specific tetracycline-inducible vector.
BioTechniques 2008;45(4):411, 414, 416 passim.
2008: Pascal Lovis; Elodie Roggli; D Ross Laybutt; Sonia Gattesco; Jiang-Yan Yang; Christian Widmann; Amar Abderrahmani; Romano Regazzi
Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction.
Diabetes 2008;57(10):2728-36.
2008: Jannick Pétremand; Amar Abderrahmani; Christian Widmann
Genetics and molecular biology: HDLs and their multiple ways to protect cells.
Current opinion in lipidology 2008;19(1):95-7.
2007: Jiang-Yan Yang; Nathalie Moulin; Miguel X van Bemmelen; Gilles Dubuis; Thomas Tawadros; Jacques-Antoine Haefliger; Gérard Waeber; Christian Widmann
Splice variant-specific stabilization of JNKs by IB1/JIP1.
Cellular signalling 2007;19(10):2201-7.
2007: David Michod; Christian Widmann
DNA-damage sensitizers: potential new therapeutical tools to improve chemotherapy.
Critical reviews in oncology/hematology 2007;63(2):160-71.
2007: Olivier Pittet; David Petermann; David Michod; Thorsten Krueger; Cai Cheng; Hans-Beat Ris; Christian Widmann
Effect of the TAT-RasGAP(317-326) peptide on apoptosis of human malignant mesothelioma cells and fibroblasts exposed to meso-tetra-hydroxyphenyl-chlorin and light.
Journal of photochemistry and photobiology. B, Biology 2007;88(1):29-35.
2007: Amar Abderrahmani; Guy Niederhauser; D Favre; Saida Abdelli; Mourad Ferdaoussi; J Y Yang; Romano Regazzi; Christian Widmann; Gérard Waeber
Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta cells.
Diabetologia 2007;50(6):1304-14.
2007: David Michod; Christian Widmann
TAT-RasGAP317-326 requires p53 and PUMA to sensitize tumor cells to genotoxins.
Molecular cancer research : MCR 2007;5(5):497-507.
2007: Birthe Ross; Ole Kristensen; Dimitri Favre; Joël Walicki; Jette S Kastrup; Christian Widmann; Michael Gajhede
High resolution crystal structures of the p120 RasGAP SH3 domain.
Biochemical and biophysical research communications 2007;353(2):463-8.
2006: Iveta Dobreva; Gérard Waeber; Christian Widmann
Lipoproteins and mitogen-activated protein kinase signaling: a role in atherogenesis?
Current opinion in lipidology 2006;17(2):110-21.
2006: Iveta Dobreva; Gérard Waeber; Richard W James; Christian Widmann
Interleukin-8 secretion by fibroblasts induced by low density lipoproteins is p38 MAPK-dependent and leads to cell spreading and wound closure.
The Journal of biological chemistry 2006;281(1):199-205.
2005: Jiang-Yan Yang; Joël Walicki; Amar Abderrahmani; Marion Cornu; Gérard Waeber; Bernard Thorens; Christian Widmann
Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion.
The Journal of biological chemistry 2005;280(38):32835-42.
2005: Iveta Dobreva; Olaf Zschörnig; Gérard Waeber; Richard W James; Christian Widmann
Cholesterol is the major component of native lipoproteins activating the p38 mitogen-activated protein kinases.
Biological chemistry 2005;386(9):909-18.
2005: Jiang-Yan Yang; Joël Walicki; David Michod; Gilles Dubuis; Christian Widmann
Impaired Akt activity down-modulation, caspase-3 activation, and apoptosis in cells expressing a caspase-resistant mutant of RasGAP at position 157.
Molecular biology of the cell 2005;16(8):3511-20.
2005: Christian Widmann
[Survival mechanisms to cellular stress].
Revue médicale suisse 2005;1(17):1141-6.
2004: Jiang-Yan Yang; David Michod; Joël Walicki; Brona M Murphy; Shailaja Kasibhatla; Seamus Martin; Christian Widmann
Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions.
Molecular and cellular biology 2004;24(23):10425-36.
2004: David Michod; Jiang-Yan Yang; Jianhua Chen; Christophe Bonny; Christian Widmann
A RasGAP-derived cell permeable peptide potently enhances genotoxin-induced cytotoxicity in tumor cells.
Oncogene 2004;23(55):8971-8.
2004: Jiang-Yan Yang; David Michod; Joël Walicki; Christian Widmann
Surviving the kiss of death.
Biochemical pharmacology 2004;68(6):1027-31.
2004: Babett Bartling; Jiang-Yan Yang; David Michod; Christian Widmann; Rolf Lewensohn; Boris Zhivotovsky
RasGTPase-activating protein is a target of caspases in spontaneous apoptosis of lung carcinoma cells and in response to etoposide.
Carcinogenesis 2004;25(6):909-21.
2004: Nathalie Moulin; Christian Widmann
Islet-brain (IB)/JNK-interacting proteins (JIPs): future targets for the treatment of neurodegenerative diseases?
Current neurovascular research 2004;1(2):111-27.
2003: Iveta Dobreva; Gérard Waeber; Vincent Mooser; Richard W James; Christian Widmann
LDLs induce fibroblast spreading independently of the LDL receptor via activation of the p38 MAPK pathway.
Journal of lipid research 2003;44(12):2382-90.
2002: Jian-Yan Yang; Christian Widmann
A subset of caspase substrates functions as the Jekyll and Hyde of apoptosis.
European cytokine network 2002;13(4):404-6.
2002: Jiang-Yan Yang; Christian Widmann
The RasGAP N-terminal fragment generated by caspase cleavage protects cells in a Ras/PI3K/Akt-dependent manner that does not rely on NFkappa B activation.
The Journal of biological chemistry 2002;277(17):14641-6.
2002: Thomas Schlesinger; Christelle Bonvin; Matthew B Jarpe; Gary R Fanger; Jean-René Cardinaux; Gary L Johnson; Christian Widmann
Apoptosis stimulated by the 91-kDa caspase cleavage MEKK1 fragment requires translocation to soluble cellular compartments.
The Journal of biological chemistry 2002;277(12):10283-91.
2002: Christelle Bonvin; Audrey Guillon; Miguel X van Bemmelen; Pär Gerwins; Gary L Johnson; Christian Widmann
Role of the amino-terminal domains of MEKKs in the activation of NF kappa B and MAPK pathways and in the regulation of cell proliferation and apoptosis.
Cellular signalling 2002;14(2):123-31.
2001: Jiang-Yan Yang; Christian Widmann
Antiapoptotic signaling generated by caspase-induced cleavage of RasGAP.
Molecular and cellular biology 2001;21(16):5346-58.
2001: Christian Widmann; Susan Sather; R Oyer; Gary L Johnson; S C Dreskin
In vitro activity of MEKK2 and MEKK3 in detergents is a function of a valine to serine difference in the catalytic domain.
Biochimica et biophysica acta 2001;1547(1):167-73.
2000: Toshiaki Yujiri; Marti Ware; Christian Widmann; R Oyer; D Russell; E Chan; Yuzuru Zaitsu; P Clarke; K Tyler; Yoshitomo Oka; Gary R Fanger; P Henson; Gary L Johnson
MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7272-7.
2000: Gérard Waeber; Jérôme Delplanque; Christophe Bonny; Vincent Mooser; M Steinmann; Christian Widmann; A Maillard; Judith Miklossy; Christian Dina; El Habib Hani; Nathalie Vionnet; Pascal Nicod; Philippe Boutin; philippe froguel
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes.
Nature genetics 2000;24(3):291-5.
2000: J B Pellet; Jacques-Antoine Haefliger; Julie K Staple; Christian Widmann; Egbert Welker; Harald Hirling; Christophe Bonny; P Nicod; Stefan Catsicas; Gérard Waeber; Beat M Riederer
Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brain.
The European journal of neuroscience 2000;12(2):621-32.
1999: S Gibson; Christian Widmann; Gary L Johnson
Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents.
The Journal of biological chemistry 1999;274(16):10916-22.
1999: Christian Widmann; S Gibson; Matthew B Jarpe; Gary L Johnson
Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.
Physiological reviews 1999;79(1):143-80.
1998: Matthew B Jarpe; Christian Widmann; C Knall; Thomas Schlesinger; S Gibson; Toshiaki Yujiri; Gary R Fanger; Erwin W Gelfand; Gary L Johnson
Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death.
Oncogene 1998;17(11 Reviews):1475-82.
1998: Christian Widmann; Pär Gerwins; N L Johnson; Matthew B Jarpe; Gary L Johnson
MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis.
Molecular and cellular biology 1998;18(4):2416-29.
1998: Christian Widmann; S Gibson; Gary L Johnson
Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals.
The Journal of biological chemistry 1998;273(12):7141-7.
1998: Gary R Fanger; Christian Widmann; Amy C Porter; Susan Sather; Gary L Johnson; Richard R Vaillancourt
14-3-3 proteins interact with specific MEK kinases.
The Journal of biological chemistry 1998;273(6):3476-83.
1997: Christian Widmann; N L Johnson; A M Gardner; R J Smith; Gary L Johnson
Potentiation of apoptosis by low dose stress stimuli in cells expressing activated MEK kinase 1.
Oncogene 1997;15(20):2439-47.
1997: Christian Widmann; Wanda Dolci; Bernard Thorens
Internalization and homologous desensitization of the GLP-1 receptor depend on phosphorylation of the receptor carboxyl tail at the same three sites.
Molecular endocrinology (Baltimore, Md.) 1997;11(8):1094-102.
1997: Gary R Fanger; Pär Gerwins; Christian Widmann; Matthew B Jarpe; Gary L Johnson
MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases?
Current opinion in genetics & development 1997;7(1):67-74.