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David Wieczorek

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Robert Gaffin; Paul H Goldspink; Lynley S Heinrich; Evangelia G Kranias; James R Peña; David F Wieczorek; Marco S L Alves; Shamim A K Chowdhury; Fernando A L Dias; Beata M Wolska
Long-term rescue of a familial hypertrophic cardiomyopathy caused by a mutation in the thin filament protein, tropomyosin, via modulation of a calcium cycling protein.
Robert Gaffin; Cibele T D Ribeiro; David F Wieczorek; Marco S L Alves; Shamim A K Chowdhury; Fernando A L Dias; Rosalvo T H Fogaca; Beata M Wolska
Effects of nicotine administration in a mouse model of familial hypertrophic cardiomyopathy, α-tropomyosin D175N.
Chehade N Karam; Chad M Warren; Sudarsan Rajan; Pieter P de Tombe; David F Wieczorek; R John Solaro
Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.

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All Publications

2011: Robert Gaffin; Paul H Goldspink; Lynley S Heinrich; Evangelia G Kranias; James R Peña; David F Wieczorek; Marco S L Alves; Shamim A K Chowdhury; Fernando A L Dias; Beata M Wolska
Long-term rescue of a familial hypertrophic cardiomyopathy caused by a mutation in the thin filament protein, tropomyosin, via modulation of a calcium cycling protein.
Journal of molecular and cellular cardiology 2011;51(5):812-20.
2011: Robert Gaffin; Cibele T D Ribeiro; David F Wieczorek; Marco S L Alves; Shamim A K Chowdhury; Fernando A L Dias; Rosalvo T H Fogaca; Beata M Wolska
Effects of nicotine administration in a mouse model of familial hypertrophic cardiomyopathy, α-tropomyosin D175N.
American journal of physiology. Heart and circulatory physiology 2011;301(4):H1646-55.
2011: Chehade N Karam; Chad M Warren; Sudarsan Rajan; Pieter P de Tombe; David F Wieczorek; R John Solaro
Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.
Journal of muscle research and cell motility 2011;31(5-6):315-22.
2011: Katherine Sheehan; Grace M Arteaga; Aaron C Hinken; Fernando A Dias; Cibele Ribeiro; David F Wieczorek; R John Solaro; Beata M Wolska
Functional effects of a tropomyosin mutation linked to FHC contribute to maladaptation during acidosis.
Journal of molecular and cellular cardiology 2011;50(3):442-50.
2011: Nabeel J Al Moamen; Vikram Prasad; Ilona Bodi; Marian L Miller; Michelle L Neiman; Valerie M Lasko; Seth L Alper; David F Wieczorek; John N Lorenz; Gary E Shull
Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure.
Journal of molecular and cellular cardiology 2011;50(1):137-46.
2010: James R Peña; Ariani C Szkudlarek; Chad M Warren; Lynley S Heinrich; Robert Gaffin; Ganapathy Jagatheesan; Federica del Monte; Roger J Hajjar; Paul H Goldspink; R John Solaro; David F Wieczorek; Beata M Wolska
Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy.
Journal of molecular and cellular cardiology 2010;49(6):993-1002.
2010: Ganapathy Jagatheesan; Sudarsan Rajan; Rafeeq P H Ahmed; Natalia N Petrashevskaya; Greg Boivin; Grace M Arteaga; Hyun-Jin Tae; Stephen B Liggett; R John Solaro; David F Wieczorek
Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity.
Journal of muscle research and cell motility 2010;31(3):227-39.
2010: Ganapathy Jagatheesan; Sudarsan Rajan; David F Wieczorek
Investigations into tropomyosin function using mouse models.
Journal of molecular and cellular cardiology 2010;48(5):893-8.
2010: Sudarsan Rajan; Ganapathy Jagatheesan; Chehade N Karam; Marco L Alves; Ilona Bodi; Arnold Schwartz; Christian F Bulcao; Karen M D'Souza; Shahab A Akhter; Gregory P Boivin; Dipak K Dube; Natalia N Petrashevskaya; Andrew B Herr; Roger Hullin; Stephen B Liggett; Beata M Wolska; R John Solaro; David F Wieczorek
Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform.
Circulation 2010;121(3):410-8.
2009: Ganapathy Jagatheesan; Sudarsan Rajan; Emily M Schulz; Rafeeq P H Ahmed; Natalia N Petrashevskaya; Arnold Schwartz; Gregory P Boivin; Grace M Arteaga; Tao Wang; Yi-Gang Wang; Muhammad Ashraf; Stephen B Liggett; John Lorenz; R John Solaro; David F Wieczorek
An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity.
American journal of physiology. Heart and circulatory physiology 2009;297(1):H181-90.
2008: Galina Schevzov; Thomas Fath; Bernadette Vrhovski; Nicole Vlahovich; Sudarsan Rajan; Jeff Hook; Josephine E Joya; Frances A Lemckert; Franz Puttur; Jim J-C Lin; Edna C Hardeman; David F Wieczorek; Geraldine M O'Neill; Peter W Gunning
Divergent regulation of the sarcomere and the cytoskeleton.
The Journal of biological chemistry 2008;283(1):275-83.
2008: David F Wieczorek; Ganapathy Jagatheesan; Sudarsan Rajan
The role of tropomyosin in heart disease.
Advances in experimental medicine and biology 2008;644():132-42.
2008: Chad M Warren; Grace M Arteaga; Sudarsan Rajan; Rafeeq Ahmed; David F Wieczorek; R John Solaro
Use of 2-D DIGE analysis reveals altered phosphorylation in a tropomyosin mutant (Glu54Lys) linked to dilated cardiomyopathy.
Proteomics 2008;8(1):100-5.
2007: Ganapathy Jagatheesan; Sudarsan Rajan; Natalia N Petrashevskaya; Arnold Schwartz; Greg Boivin; Grace M Arteaga; R John Solaro; Stephen B Liggett; David F Wieczorek
Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis.
American journal of physiology. Heart and circulatory physiology 2007;293(2):H949-58.
2007: Sudarsan Rajan; Rafeeq Ahmed; Ganapathy Jagatheesan; Natalia N Petrashevskaya; Gregory P Boivin; Dalia Urboniene; Grace M Arteaga; Beata M Wolska; R John Solaro; Stephen B Liggett; David F Wieczorek
Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity.
Circulation research 2007;101(2):205-14.
2006: Sudarsan Rajan; Sarah S Williams; Ganapathy Jagatheesan; Rafeeq Ahmed; Geraldine Fuller-Bicer; Arnold Schwartz; Bruce Aronow; David F Wieczorek
Microarray analysis of gene expression during early stages of mild and severe cardiac hypertrophy.
Physiological genomics 2006;27(3):309-17.
2006: Gopal J Babu; Poornima Bhupathy; Natalia N Petrashevskaya; Honglan Wang; Sripriya Raman; Debra Wheeler; Ganapathy Jagatheesan; David F Wieczorek; Arnold Schwartz; Paul Janssen; Mark T Ziolo; Muthu Periasamy
Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility.
The Journal of biological chemistry 2006;281(7):3972-9.
2005: Robert W Zajdel; Christopher R Denz; Matthew D McLean; Syamalima Dube; Mariappan Muthuchamy; Bernard J Poiesz; David F Wieczorek; Dipak K Dube
Diminished myofibril organization in mutant axolotl hearts transfected with site-directed mutants of sarcomeric tropomyosins.
Cardiovascular toxicology 2005;5(1):75-90.
2004: Ganapathy Jagatheesan; Sudarsan Rajan; Natalia N Petrashevskaya; Arnold Schwartz; Greg Boivin; Grace M Arteaga; Pieter P de Tombe; R John Solaro; David F Wieczorek
Physiological significance of troponin T binding domains in striated muscle tropomyosin.
American journal of physiology. Heart and circulatory physiology 2004;287(4):H1484-94.
2003: Eileen M Burkart; Grace M Arteaga; Marius P Sumandea; Rethinasamy Prabhakar; David F Wieczorek; R John Solaro
Altered signaling surrounding the C-lobe of cardiac troponin C in myofilaments containing an alpha-tropomyosin mutation linked to familial hypertrophic cardiomyopathy.
Journal of molecular and cellular cardiology 2003;35(10):1285-93.
2003: Rethinasamy Prabhakar; Natalia N Petrashevskaya; Arnold Schwartz; Bruce Aronow; Gregory P Boivin; Jeffery D Molkentin; David F Wieczorek
A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutation.
Molecular and cellular biochemistry 2003;251(1-2):33-42.
2003: Ganapathy Jagatheesan; Sudarsan Rajan; Natalia N Petrashevskaya; Arnold Schwartz; Greg Boivin; Susan Vahebi; Pieter DeTombe; R John Solaro; Erin Hall (Maiden: Labitzke); George M Hilliard; David F Wieczorek
Functional importance of the carboxyl-terminal region of striated muscle tropomyosin.
The Journal of biological chemistry 2003;278(25):23204-11.
2002: Kathy Pieples; Grace M Arteaga; R John Solaro; Ingrid L Grupp; John N Lorenz; Gregory P Boivin; Ganapathy Jagatheesan; Erin Hall (Maiden: Labitzke); Pieter DeTombe; John P Konhilas; Thomas C Irving; David F Wieczorek
Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation.
American journal of physiology. Heart and circulatory physiology 2002;283(4):H1344-53.
2001: Rethinasamy Prabhakar; Gregory P Boivin; Ingrid L Grupp; Brian D Hoit; Grace M Arteaga; R John Solaro; David F Wieczorek
A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice.
Journal of molecular and cellular cardiology 2001;33(10):1815-28.
2001: Jitandrakumar R Patel; Daniel P Fitzsimons; Scott H Buck; Mariappan Muthuchamy; David F Wieczorek; Richard L Moss
PKA accelerates rate of force development in murine skinned myocardium expressing alpha- or beta-tropomyosin.
American journal of physiology. Heart and circulatory physiology 2001;280(6):H2732-9.
2000: C C Evans; J R Pena; Ronald M Phillips; Mariappan Muthuchamy; David F Wieczorek; R John Solaro; Beata M Wolska
Altered hemodynamics in transgenic mice harboring mutant tropomyosin linked to hypertrophic cardiomyopathy.
American journal of physiology. Heart and circulatory physiology 2000;279(5):H2414-23.
2000: Kathy Pieples; David F Wieczorek
Tropomyosin 3 increases striated muscle isoform diversity.
Biochemistry 2000;39(28):8291-7.
2000: Robert W Zajdel; Matthew D McLean; G Isitmangil; Larry F Lemanski; David F Wieczorek; Dipak K Dube
Alteration of cardiac myofibrillogenesis by liposome-mediated delivery of exogenous proteins and nucleic acids into whole embryonic hearts.
Anatomy and embryology 2000;201(4):217-28.
1999: Rethinasamy Prabhakar; Gregory P Boivin; Brian D Hoit; David F Wieczorek
Rescue of high expression beta-tropomyosin transgenic mice by 5-propyl-2-thiouracil. Regulating the alpha-myosin heavy chain promoter.
The Journal of biological chemistry 1999;274(41):29558-63.
1999: Mariappan Muthuchamy; Kathy Pieples; P Rethinasamy; Brian D Hoit; Ingrid L Grupp; Gregory P Boivin; Beata M Wolska; C Evans; R John Solaro; David F Wieczorek
Mouse model of a familial hypertrophic cardiomyopathy mutation in alpha-tropomyosin manifests cardiac dysfunction.
Circulation research 1999;85(1):47-56.
1999: Beata M Wolska; Rebecca S Keller; C C Evans; KA Palmiter; Ronald M Phillips; Mariappan Muthuchamy; J Oehlenschlager; David F Wieczorek; Pieter P de Tombe; R John Solaro
Correlation between myofilament response to Ca2+ and altered dynamics of contraction and relaxation in transgenic cardiac cells that express beta-tropomyosin.
Circulation research 1999;84(7):745-51.
1998: Robert W Zajdel; Matthew D McLean; Sharon L Lemanski; Mariappan Muthuchamy; David F Wieczorek; Larry F Lemanski; Dipak K Dube
Ectopic expression of tropomyosin promotes myofibrillogenesis in mutant axolotl hearts.
Developmental dynamics : an official publication of the American Association of Anatomists 1998;213(4):412-20.
1998: Mariappan Muthuchamy; Gregory P Boivin; Ingrid L Grupp; David F Wieczorek
Beta-tropomyosin overexpression induces severe cardiac abnormalities.
Journal of molecular and cellular cardiology 1998;30(8):1545-57.
1998: P Rethinasamy; Mariappan Muthuchamy; Timothy E Hewett; Greg Boivin; Beata M Wolska; C Evans; R John Solaro; David F Wieczorek
Molecular and physiological effects of alpha-tropomyosin ablation in the mouse.
Circulation research 1998;82(1):116-23.
1997: Mariappan Muthuchamy; P Rethinasamy; David F Wieczorek
Tropomyosin structure and function new insights.
Trends in cardiovascular medicine 1997;7(4):124-8.
1996: K A Palmiter; Y Kitada; Mariappan Muthuchamy; David F Wieczorek; R John Solaro
Exchange of beta- for alpha-tropomyosin in hearts of transgenic mice induces changes in thin filament response to Ca2+, strong cross-bridge binding, and protein phosphorylation.
The Journal of biological chemistry 1996;271(20):11611-4.
1995: Mariappan Muthuchamy; Ingrid L Grupp; G Grupp; B A O'Toole; Ann B Kier; Gregory P Boivin; J Neumann; David F Wieczorek
Molecular and physiological effects of overexpressing striated muscle beta-tropomyosin in the adult murine heart.
The Journal of biological chemistry 1995;270(51):30593-603.
1993: Mariappan Muthuchamy; L Pajak; Philip N Howles; Thomas Doetschman; David F Wieczorek
Developmental analysis of tropomyosin gene expression in embryonic stem cells and mouse embryos.
Molecular and cellular biology 1993;13(6):3311-23.
1992: Mariappan Muthuchamy; L Pajak; David F Wieczorek
Induction of endogenous myosin light chain 1 and cardiac alpha-actin expression in L6E9 cells by MyoD1.
The Journal of biological chemistry 1992;267(26):18728-34.
1992: R J Diebold; Walter J Koch; P T Ellinor; J J Wang; Mariappan Muthuchamy; David F Wieczorek; Arnold Schwartz
Mutually exclusive exon splicing of the cardiac calcium channel alpha 1 subunit gene generates developmentally regulated isoforms in the rat heart.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1497-501.
1991: L Pajak; M Mariappan; David F Wieczorek
Reprogramming of myosin light chain 1/3 expression in muscle heterokaryons.
Developmental biology 1991;145(1):28-39.
1991: David F Wieczorek; S R Hughes
Developmentally regulated cDNA expressed exclusively in neural tissue.
Brain research. Molecular brain research 1991;10(1):33-41.
1991: Per-Olof Hasselgren; JV Tricoli; David F Wieczorek; K A Steigerwald; U Angerås; M Hall-Angerås; Josef E Fischer
Reduced levels of mRNA for myofibrillar proteins in skeletal muscle from septic rats.
Life sciences 1991;49(10):753-60.
1988: David F Wieczorek
Regulation of alternatively spliced alpha-tropomyosin gene expression by nerve extract.
The Journal of biological chemistry 1988;263(21):10456-63.