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Therese Wiedmer

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Biao Lu; Peter J Sims; Therese Wiedmer; Arthur H Moser; Judy K Shigenaga; Carl Grunfeld; Kenneth R Feingold
Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response.
David M Mutch; Grace O'Maille; William R Wikoff; Therese Wiedmer; Peter J Sims; Gary Siuzdak
Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice.
Ying Huang; Qian Zhao; C-X Zhou; Z-M Gu; Dong Li; H-Z Xu; Therese Wiedmer; Peter J Sims; Ke-Wen Zhao; Guo-Qiang Chen
Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells.

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All Publications

2007: Biao Lu; Peter J Sims; Therese Wiedmer; Arthur H Moser; Judy K Shigenaga; Carl Grunfeld; Kenneth R Feingold
Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response.
Biochimica et biophysica acta 2007;1771(9):1177-85.
2007: David M Mutch; Grace O'Maille; William R Wikoff; Therese Wiedmer; Peter J Sims; Gary Siuzdak
Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice.
Genome biology 2007;8(3):R38.
2006: Ying Huang; Qian Zhao; C-X Zhou; Z-M Gu; Dong Li; H-Z Xu; Therese Wiedmer; Peter J Sims; Ke-Wen Zhao; Guo-Qiang Chen
Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells.
Oncogene 2006;25(50):6618-27.
2005: Quansheng Zhou; Iris Ben-Efraim; Jo-Lawrence Bigcas; Daniela Junqueira; Therese Wiedmer; Peter J Sims
Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression.
The Journal of biological chemistry 2005;280(41):35062-8.
2004: Ke-Wen Zhao; Xi Li; Qian Zhao; Ying Huang; Dong Li; Zhen-Gang Peng; Wu-Zhong Shen; Ji Zhao; Quansheng Zhou; Zhu Chen; Peter J Sims; Therese Wiedmer; Guo-Qiang Chen
Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation.
Blood 2004;104(12):3731-8.
2004: Therese Wiedmer; Ji Zhao; Lilin Li; Quansheng Zhou; Andrea L Hevener; Jerrold M Olefsky; Linda K Curtiss; Peter J Sims
Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3).
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13296-301.
2004: Beihua Dong; Quansheng Zhou; Ji Zhao; Aimin Zhou; Ronald N Harty; Santanu Bose; Amiya Banerjee; Roger Slee; Jeanna Guenther; Bryan R G Williams; Therese Wiedmer; Peter J Sims; Robert H Silverman
Phospholipid scramblase 1 potentiates the antiviral activity of interferon.
Journal of virology 2004;78(17):8983-93.
2004: Iris Ben-Efraim; Quansheng Zhou; Therese Wiedmer; Larry Gerace; Peter J Sims
Phospholipid scramblase 1 is imported into the nucleus by a receptor-mediated pathway and interacts with DNA.
Biochemistry 2004;43(12):3518-26.
2003: Meera Nanjundan; Jun Sun; Ji Zhao; Quansheng Zhou; Peter J Sims; Therese Wiedmer
Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor.
The Journal of biological chemistry 2003;278(39):37413-8.
2003: Klaas Jan de Vries; Therese Wiedmer; Peter J Sims; Bart M Gadella
Caspase-independent exposure of aminophospholipids and tyrosine phosphorylation in bicarbonate responsive human sperm cells.
Biology of reproduction 2003;68(6):2122-34.
2003: Therese Wiedmer; Ji Zhao; Meera Nanjundan; Peter J Sims
Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane.
Biochemistry 2003;42(5):1227-33.
2002: Quansheng Zhou; Ji Zhao; Therese Wiedmer; Peter J Sims
Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1.
Blood 2002;99(11):4030-8.
2002: Jun Sun; Meera Nanjundan; Linda J Pike; Therese Wiedmer; Peter J Sims
Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor.
Biochemistry 2002;41(20):6338-45.
2002: Robert H Silverman; Ammar Halloum; Aimin Zhou; Beihua Dong; Fahad Al-Zoghaibi; David M Kushner; Quansheng Zhou; Ji Zhao; Therese Wiedmer; Peter J Sims
Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1.
Cancer research 2002;62(2):397-402.
2001: Jun Sun; Ji Zhao; Martin A Schwartz; Jean Y J Wang; Therese Wiedmer; Peter J Sims
c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1.
The Journal of biological chemistry 2001;276(31):28984-90.
2001: Peter J Sims; Therese Wiedmer
Unraveling the mysteries of phospholipid scrambling.
Thrombosis and haemostasis 2001;86(1):266-75.
2000: Therese Wiedmer; Quansheng Zhou; D Y Kwoh; Peter J Sims
Identification of three new members of the phospholipid scramblase gene family.
Biochimica et biophysica acta 2000;1467(1):244-53.
2000: AD Tepper; Paula Ruurs; Therese Wiedmer; Peter J Sims; Jannie Borst; Wim J van Blitterswijk
Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology.
The Journal of cell biology 2000;150(1):155-64.
2000: Quansheng Zhou; Ji Zhao; Fahad Al-Zoghaibi; Aimin Zhou; Therese Wiedmer; Robert H Silverman; Peter J Sims
Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha.
Blood 2000;95(8):2593-9.
1999: Bengt Fadeel; Bettina Gleiss; K Högstrand; J Chandra; Therese Wiedmer; Peter J Sims; J I Henter; Sten Orrenius; Afshin Samali
Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression.
Biochemical and biophysical research communications 1999;266(2):504-11.
1998: JG Stout; Q Zhou; Therese Wiedmer; Peter J Sims
Change in conformation of plasma membrane phospholipid scramblase induced by occupancy of its Ca2+ binding site.
Biochemistry 1998;37(42):14860-6.
1998: Q Zhou; Peter J Sims; Therese Wiedmer
Expression of proteins controlling transbilayer movement of plasma membrane phospholipids in the B lymphocytes from a patient with Scott syndrome.
Blood 1998;92(5):1707-12.
1998: J Zhao; Q Zhou; Therese Wiedmer; Peter J Sims
Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids.
Biochemistry 1998;37(18):6361-6.
1998: J Zhao; Q Zhou; Therese Wiedmer; Peter J Sims
Level of expression of phospholipid scramblase regulates induced movement of phosphatidylserine to the cell surface.
The Journal of biological chemistry 1998;273(12):6603-6.
1998: Q Zhou; Peter J Sims; Therese Wiedmer
Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids.
Biochemistry 1998;37(8):2356-60.
1997: Q Zhou; J Zhao; JG Stout; R A Luhm; Therese Wiedmer; Peter J Sims
Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids.
The Journal of biological chemistry 1997;272(29):18240-4.
1997: J Zhao; Peter J Sims; Therese Wiedmer
Production and characterization of a mutant cell line defective in aminophospholipid translocase.
Biochimica et biophysica acta 1997;1357(1):57-64.
1997: JG Stout; F Bassé; R A Luhm; H J Weiss; Therese Wiedmer; Peter J Sims
Scott syndrome erythrocytes contain a membrane protein capable of mediating Ca2+-dependent transbilayer migration of membrane phospholipids.
The Journal of clinical investigation 1997;99(9):2232-8.
1996: F Bassé; J G Stout; Peter J Sims; Therese Wiedmer
Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid.
The Journal of biological chemistry 1996;271(29):17205-10.
1995: Peter J Sims; Therese Wiedmer
Induction of cellular procoagulant activity by the membrane attack complex of complement.
Seminars in cell biology 1995;6(5):275-82.
1995: Edouard M Bevers; Therese Wiedmer; Paul Comfurius; J Zhao; Eric E J Smeets; Robert A Schlegel; Alan J Schroit; H J Weiss; Patrick Williamson; Robert F A Zwaal; Peter J Sims
The complex of phosphatidylinositol 4,5-bisphosphate and calcium ions is not responsible for Ca2+-induced loss of phospholipid asymmetry in the human erythrocyte: a study in Scott syndrome, a disorder of calcium-induced phospholipid scrambling.
Blood 1995;86(5):1983-91.
1994: H Kojima; D Newton-Nash; H J Weiss; J Zhao; Peter J Sims; Therese Wiedmer
Production and characterization of transformed B-lymphocytes expressing the membrane defect of Scott syndrome.
The Journal of clinical investigation 1994;94(6):2237-44.
1994: C P Chang; T Hüsler; J Zhao; Therese Wiedmer; Peter J Sims
Identity of a peptide domain of human C9 that is bound by the cell-surface complement inhibitor, CD59.
The Journal of biological chemistry 1994;269(42):26424-30.
1993: Therese Wiedmer; S E Hall; Thomas L Ortel; William H Kane; W F Rosse; Peter J Sims
Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria.
Blood 1993;82(4):1192-6.
1993: C P Chang; J Zhao; Therese Wiedmer; Peter J Sims
Contribution of platelet microparticle formation and granule secretion to the transmembrane migration of phosphatidylserine.
The Journal of biological chemistry 1993;268(10):7171-8.
1992: Edouard M Bevers; Therese Wiedmer; Paul Comfurius; S J Shattil; H J Weiss; Robert F A Zwaal; Peter J Sims
Defective Ca(2+)-induced microvesiculation and deficient expression of procoagulant activity in erythrocytes from a patient with a bleeding disorder: a study of the red blood cells of Scott syndrome.
Blood 1992;79(2):380-8.
1991: Therese Wiedmer; Peter J Sims
Participation of protein kinases in complement C5b-9-induced shedding of platelet plasma membrane vesicles.
Blood 1991;78(11):2880-6.
1991: Peter J Sims; Therese Wiedmer
The response of human platelets to activated components of the complement system.
Immunology today 1991;12(9):338-42.
1990: Therese Wiedmer; S J Shattil; M Cunningham; Peter J Sims
Role of calcium and calpain in complement-induced vesiculation of the platelet plasma membrane and in the exposure of the platelet factor Va receptor.
Biochemistry 1990;29(3):623-32.
1989: Peter J Sims; S A Rollins; Therese Wiedmer
Regulatory control of complement on blood platelets. Modulation of platelet procoagulant responses by a membrane inhibitor of the C5b-9 complex.
The Journal of biological chemistry 1989;264(32):19228-35.
1989: Peter J Sims; Therese Wiedmer; Charles T Esmon; H J Weiss; S J Shattil
Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity.
The Journal of biological chemistry 1989;264(29):17049-57.
1989: B Ando; Therese Wiedmer; Peter J Sims
The secretory release reaction initiated by complement proteins C5b-9 occurs without platelet aggregation through glycoprotein IIb-IIIa.
Blood 1989;73(2):462-7.
1988: Peter J Sims; E M Faioni; Therese Wiedmer; S J Shattil
Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity.
The Journal of biological chemistry 1988;263(34):18205-12.
1988: B Ando; Therese Wiedmer; K K Hamilton; Peter J Sims
Complement proteins C5b-9 initiate secretion of platelet storage granules without increased binding of fibrinogen or von Willebrand factor to newly expressed cell surface GPIIb-IIIa.
The Journal of biological chemistry 1988;263(24):11907-14.
1987: Therese Wiedmer; B Ando; Peter J Sims
Complement C5b-9-stimulated platelet secretion is associated with a Ca2+-initiated activation of cellular protein kinases.
The Journal of biological chemistry 1987;262(28):13674-81.