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Stanley Wiegand

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Chemicals & Drugs

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Physiology

Neovascularization, Physiologic

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Nicholas Papadopoulos; Erica A Pyles; Ashique Rafique; Michael P Rosconi; Qin Ruan; Ergang Shi; Neil Stahl; Joel Martin; George D Yancopoulos; Stanley J Wiegand
Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab.
Gerard A Lutty; D Scott McLeod; Imran A Bhutto; Stanley J Wiegand
Effect of VEGF trap on normal retinal vascular development and oxygen-induced retinopathy in the dog.
Hamish M Fraser; Keith D Morris; Stanley J Wiegand; Helen Wilson
Inhibition of vascular endothelial growth factor during the postovulatory period prevents pregnancy in the marmoset.

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2012: Nicholas Papadopoulos; Erica A Pyles; Ashique Rafique; Michael P Rosconi; Qin Ruan; Ergang Shi; Neil Stahl; Joel Martin; George D Yancopoulos; Stanley J Wiegand
Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab.
Angiogenesis 2012;15(2):171-85.
2011: Gerard A Lutty; D Scott McLeod; Imran A Bhutto; Stanley J Wiegand
Effect of VEGF trap on normal retinal vascular development and oxygen-induced retinopathy in the dog.
Investigative ophthalmology & visual science 2011;52(7):4039-47.
2010: Hamish M Fraser; Keith D Morris; Stanley J Wiegand; Helen Wilson
Inhibition of vascular endothelial growth factor during the postovulatory period prevents pregnancy in the marmoset.
Contraception 2010;82(6):572-8.
2010: Jingtai Cao; Lian Zhao; Yiwen Li; Yang Liu; Weihong Xiao; Ying Song; Lingyu Luo; Deqiang Huang; George D Yancopoulos; Stanley J Wiegand; Rong Wen
A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap.
Investigative ophthalmology & visual science 2010;51(11):6009-17.
2010: Tina Dietrich; Felix Bock; Don Yuen; Deniz Hos; Björn Bachmann; Grit Zahn; Stanley J Wiegand; Lu Chen; Claus Cursiefen
Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(2):535-9.
2010: Hailton B Oliveira; Tohru Sakimoto; Joel A D Javier; Dimitri T Azar; Stanley J Wiegand; Sandeep Jain; Jin-Hong Chang
VEGF Trap(R1R2) suppresses experimental corneal angiogenesis.
European journal of ophthalmology 2010;20(1):48-54.
2009: Björn Bachmann; E Luetjen-Drecoll; Felix Bock; Stanley J Wiegand; D Hos; Reza Dana; Friedrich E Kruse; Claus Cursiefen
Transient postoperative vascular endothelial growth factor (VEGF)-neutralisation improves graft survival in corneas with partly regressed inflammatory neovascularisation.
The British journal of ophthalmology 2009;93(8):1075-80.
2008: Graham W Aberdeen; Stanley J Wiegand; Thomas W Bonagura; Gerald J Pepe; Eugene D Albrecht
Vascular endothelial growth factor mediates the estrogen-induced breakdown of tight junctions between and increase in proliferation of microvessel endothelial cells in the baboon endometrium.
Endocrinology 2008;149(12):6076-83.
2008: Xiujun Fan; Sacha Krieg; Calvin J Kuo; Stanley J Wiegand; Marlene Rabinovitch; Maurice L Druzin; Robert M Brenner; Linda C Giudice; Nihar R Nayak
VEGF blockade inhibits angiogenesis and reepithelialization of endometrium.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(10):3571-80.
2008: Hamish M Fraser; Helen Wilson; Audrey Silvestri; Keith D Morris; Stanley J Wiegand
The role of vascular endothelial growth factor and estradiol in the regulation of endometrial angiogenesis and cell proliferation in the marmoset.
Endocrinology 2008;149(9):4413-20.
2008: Björn Bachmann; Felix Bock; Stanley J Wiegand; Kazuichi Maruyama; M Reza Dana; Friedrich E Kruse; Elke Luetjen-Drecoll; Claus Cursiefen
Promotion of graft survival by vascular endothelial growth factor a neutralization after high-risk corneal transplantation.
Archives of ophthalmology 2008;126(1):71-7.
2007: John S Rudge; Jocelyn Holash; Donna Hylton; Michelle Russell; Shelly Jiang; Raymond Leidich; Nick Papadopoulos; Erica A Pyles; Al Torri; Stanley J Wiegand; Gavin Thurston; Neil stahl; George D Yancopoulos
VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(47):18363-70.
2007: P D Taylor; H Wilson; Stephen G Hillier; Stanley J Wiegand; Hamish M Fraser
Effects of inhibition of vascular endothelial growth factor at time of selection on follicular angiogenesis, expansion, development and atresia in the marmoset.
Molecular human reproduction 2007;13(10):729-36.
2007: Richard Torres; Susan D Croll; Jeffrey Vercollone; Joel Reinhardt; Jennifer Griffiths; Stephanie Zabski; Keith D Anderson; Niels Adams; Lori Gowen; Mark W Sleeman; David M Valenzuela; Stanley J Wiegand; George D Yancopoulos; Andrew J Murphy
Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses.
Pain 2007;130(3):267-78.
2007: Ivan Lobov; R A Renard; Nick Papadopoulos; nicholas gale; Gavin Thurston; George D Yancopoulos; Stanley J Wiegand
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3219-24.
2007: Lora J Kasselman; Jennifer Kintner; Alexandra Sideris; Elizabeth Pasnikowski; Jason W Krellman; Sagar Shah; John S Rudge; George D Yancopoulos; Stanley J Wiegand; Susan D Croll
Dexamethasone treatment and ICAM-1 deficiency impair VEGF-induced angiogenesis in adult brain.
Journal of vascular research 2007;44(4):283-91.
2006: Hamish M Fraser; Helen Wilson; Christine Wulff; John S Rudge; Stanley J Wiegand
Administration of vascular endothelial growth factor Trap during the 'post-angiogenic' period of the luteal phase causes rapid functional luteolysis and selective endothelial cell death in the marmoset.
Reproduction (Cambridge, England) 2006;132(4):589-600.
2006: Lora J Kasselman; Alexandra Sideris; Chantal Bruno; William R Perez; Ning Cai; Jamee N Nicoletti; Stanley J Wiegand; Susan D Croll
BDNF: a missing link between sympathetic dysfunction and inflammatory disease?
Journal of neuroimmunology 2006;175(1-2):118-27.
2006: Akiyoshi Uemura; Sentaro Kusuhara; Stanley J Wiegand; Ruth T Yu; Shin-ichi Nishikawa
Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes.
The Journal of clinical investigation 2006;116(2):369-77.
2005: Katherine E Wortley; Keith D Anderson; Jason Yasenchak; Andrew Murphy; David M Valenzuela; Sabrina Diano; George D Yancopoulos; Stanley J Wiegand; Mark W Sleeman
Agouti-related protein-deficient mice display an age-related lean phenotype.
Cell metabolism 2005;2(6):421-7.
2005: Nihar R Nayak; Calvin J Kuo; Tejal A Desai; Stanley J Wiegand; Bill L Lasley; Linda C Giudice; Robert M Brenner
Expression, localization and hormonal control of angiopoietin-1 in the rhesus macaque endometrium: potential role in spiral artery growth.
Molecular human reproduction 2005;11(11):791-9.
2005: Hamish M Fraser; Helen Wilson; Keith D Morris; Ian Swanston; Stanley J Wiegand
Vascular endothelial growth factor Trap suppresses ovarian function at all stages of the luteal phase in the macaque.
The Journal of clinical endocrinology and metabolism 2005;90(10):5811-8.
2005: Gavin Thurston; Quan Wang; Fabienne Baffert; John S Rudge; Nicholas Papadopoulos; Danielle Jean-Guillaume; Stanley J Wiegand; George D Yancopoulos; Donald M McDonald
Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period.
Development (Cambridge, England) 2005;132(14):3317-26.
2005: Yuji Oshima; Sachiko Oshima; Hiroyuki Nambu; Shu Kachi; Kyoichi Takahashi; Naoyasu Umeda; Jikui Shen; Aling Dong; Rajendra S Apte; Elia J Duh; Sean F Hackett; Godwin Okoye; Kazuki Ishibashi; James T Handa; Michele Melia; Stanley J Wiegand; George D Yancopoulos; Donald J Zack; Peter A Campochiaro
Different effects of angiopoietin-2 in different vascular beds: new vessels are most sensitive.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(8):963-5.
2005: Lynn E Macdonald; Katherine E Wortley; Lori C Gowen; Keith D Anderson; Jane D Murray; William T Poueymirou; Mary V Simmons; Dianna Barber; David M Valenzuela; Aris N Economides; Stanley J Wiegand; George D Yancopoulos; Mark W Sleeman; Andrew J Murphy
Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2496-501.
2005: Mark W Sleeman; Katherine E Wortley; Ka-Man V Lai; Lori C Gowen; Jennifer Kintner; William O Kline; Karen Garcia; Trevor N Stitt; George D Yancopoulos; Stanley J Wiegand; David J Glass
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.
Nature medicine 2005;11(2):199-205.
2005: Hamish M Fraser; Helen Wilson; John S Rudge; Stanley J Wiegand
Single injections of vascular endothelial growth factor trap block ovulation in the macaque and produce a prolonged, dose-related suppression of ovarian function.
The Journal of clinical endocrinology and metabolism 2005;90(2):1114-22.
2005: John S Rudge; G Thurston; S Davis; N Papadopoulos; nicholas gale; Stanley J Wiegand; George D Yancopoulos
VEGF trap as a novel antiangiogenic treatment currently in clinical trials for cancer and eye diseases, and VelociGene- based discovery of the next generation of angiogenesis targets.
Cold Spring Harbor symposia on quantitative biology 2005;70():411-8.
2005: Gavin Thurston; John S Rudge; Ella Ioffe; Nick Papadopoulos; Christopher Daly; Srilatha Vuthoori; Thomas J Daly; Stanley J Wiegand; George D Yancopoulos
The anti-inflammatory actions of angiopoietin-1.
EXS 2005;(94):233-45.
2004: Susann Blüher; Stergios J Moschos; John Bullen; Efi Kokkotou; Eleftheria Maratos-Flier; Stanley J Wiegand; Mark W Sleeman; Mark W Sleemann; Christos S Mantzoros
Ciliary neurotrophic factorAx15 alters energy homeostasis, decreases body weight, and improves metabolic control in diet-induced obese and UCP1-DTA mice.
Diabetes 2004;53(11):2787-96.
2004: Randolph Hutter; Francine E Carrick; Carolina Valdiviezo; Claire Wolinsky; John S Rudge; Stanley J Wiegand; Valentin Fuster; Juan J Badimon; Bernhard V Sauter
Vascular endothelial growth factor regulates reendothelialization and neointima formation in a mouse model of arterial injury.
Circulation 2004;110(16):2430-5.
2004: Claus Cursiefen; Jingtai Cao; Lu Chen; Ying Liu; Kazuichi Maruyama; David Jackson; Friedrich E Kruse; Stanley J Wiegand; M Reza Dana; J Wayne Streilein
Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival.
Investigative ophthalmology & visual science 2004;45(8):2666-73.
2004: Susan D Croll; Richard M Ransohoff; Ning Cai; Qing Zhang; Francis J Martin; Tao Wei; Lora J Kasselman; Jennifer Kintner; Andrew J Murphy; George D Yancopoulos; Stanley J Wiegand
VEGF-mediated inflammation precedes angiogenesis in adult brain.
Experimental neurology 2004;187(2):388-402.
2004: Katherine E Wortley; Keith D Anderson; Karen Garcia; Jane D Murray; Lubomira Malinova; Rong Liu; Marshena Moncrieffe; Karen Thabet; Hilary J Cox; George D Yancopoulos; Stanley J Wiegand; Mark W Sleeman
Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):8227-32.
2004: Hiroyuki Nambu; Rie Nambu; Yuji Oshima; Sean F Hackett; Godwin Okoye; Stanley J Wiegand; George D Yancopoulos; Donald J Zack; Peter A Campochiaro
Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood-retinal barrier.
Gene therapy 2004;11(10):865-73.
2004: Claus Cursiefen; Lu Chen; Leonardo P Borges; David Jackson; Jingtai Cao; Czeslaw Radziejewski; Patricia A D'Amore; M Reza Dana; Stanley J Wiegand; J Wayne Streilein
VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment.
The Journal of clinical investigation 2004;113(7):1040-50.
2003: Mark W Sleeman; Karen Garcia; Rong Liu; Jane D Murray; L Malinova; M Moncrieffe; George D Yancopoulos; Stanley J Wiegand
Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14297-302.
2003: Keith D Anderson; PD Lambert; TL Corcoran; Jane D Murray; Karen Thabet; George D Yancopoulos; Stanley J Wiegand
Activation of the hypothalamic arcuate nucleus predicts the anorectic actions of ciliary neurotrophic factor and leptin in intact and gold thioglucose-lesioned mice.
Journal of neuroendocrinology 2003;15(7):649-60.
2003: Yoshitsugu Saishin; Yumiko Saishin; Kyoichi Takahashi; Raquel Lima e Silva; Donna Hylton; John S Rudge; Stanley J Wiegand; Peter A Campochiaro
VEGF-TRAP(R1R2) suppresses choroidal neovascularization and VEGF-induced breakdown of the blood-retinal barrier.
Journal of cellular physiology 2003;195(2):241-8.
2003: Antonia M Joussen; Vassiliki Poulaki; Nicholas Mitsiades; Stephen U Stechschulte; Bernd Kirchhof; Darlene A Dartt; Guo-Hua Fong; John S Rudge; Stanley J Wiegand; George D Yancopoulos; Anthony P Adamis
VEGF-dependent conjunctivalization of the corneal surface.
Investigative ophthalmology & visual science 2003;44(1):117-23.
2002: Akiyoshi Uemura; Minetaro Ogawa; Masanori Hirashima; Takashi Fujiwara; Shinji Koyama; Hitoshi Takagi; Yoshihito Honda; Stanley J Wiegand; George D Yancopoulos; Shin-Ichi Nishikawa
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells.
The Journal of clinical investigation 2002;110(11):1619-28.
2002: nicholas gale; Gavin Thurston; Sean F Hackett; Roumiana Renard; Quan Wang; Joyce McClain; Cliff Martin; Charles L Witte; Marlys H Witte; David Jackson; Chitra Suri; Peter A Campochiaro; Stanley J Wiegand; George D Yancopoulos
Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.
Developmental cell 2002;3(3):411-23.
2002: Jocelyn Holash; Sam Davis; Nick Papadopoulos; Susan D Croll; Lillian Ho; Michelle Russell; Patricia Boland; Raymond Leidich; Donna Hylton; Elena Burova; Ella Ioffe; Tammy Huang; Czeslaw Radziejewski; Kevin Bailey; James P Fandl; Thomas J Daly; Stanley J Wiegand; George D Yancopoulos; John S Rudge
VEGF-Trap: a VEGF blocker with potent antitumor effects.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11393-8.
2002: Sean F Hackett; Stanley J Wiegand; George D Yancopoulos; Peter A Campochiaro
Angiopoietin-2 plays an important role in retinal angiogenesis.
Journal of cellular physiology 2002;192(2):182-7.
2002: Christine Wulff; Helen Wilson; Stanley J Wiegand; John S Rudge; Hamish M Fraser
Prevention of thecal angiogenesis, antral follicular growth, and ovulation in the primate by treatment with vascular endothelial growth factor Trap R1R2.
Endocrinology 2002;143(7):2797-807.
2002: Antonia M Joussen; Vassiliki Poulaki; Akitaka Tsujikawa; Wenying Qin; Tamim Qaum; Qingwen Xu; Yasufumi Moromizato; Sven-Erik Bursell; Stanley J Wiegand; John S Rudge; Ella Ioffe; George D Yancopoulos; Anthony P Adamis
Suppression of diabetic retinopathy with angiopoietin-1.
The American journal of pathology 2002;160(5):1683-93.
2002: Vassiliki Poulaki; Wenying Qin; Antonia M Joussen; Peter Hurlbut; Stanley J Wiegand; John S Rudge; George D Yancopoulos; Anthony P Adamis
Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF.
The Journal of clinical investigation 2002;109(6):805-15.
2002: Christine Wulff; Helen Wilson; Sarah E Dickson; Stanley J Wiegand; Hamish M Fraser
Hemochorial placentation in the primate: expression of vascular endothelial growth factor, angiopoietins, and their receptors throughout pregnancy.
Biology of reproduction 2002;66(3):802-12.
2002: Antonia M Joussen; Vassiliki Poulaki; Wenying Qin; Bernd Kirchhof; Nicholas Mitsiades; Stanley J Wiegand; John S Rudge; George D Yancopoulos; Anthony P Adamis
Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo.
The American journal of pathology 2002;160(2):501-9.
2002: nicholas gale; Gavin Thurston; S Davis; Stanley J Wiegand; Jocelyn Holash; John S Rudge; George D Yancopoulos
Complementary and coordinated roles of the VEGFs and angiopoietins during normal and pathologic vascular formation.
Cold Spring Harbor symposia on quantitative biology 2002;67():267-73.
2001: Tamim Qaum; Qingwen Xu; Antonia M Joussen; M W Clemens; W Qin; K Miyamoto; H Hassessian; Stanley J Wiegand; John S Rudge; George D Yancopoulos; Anthony P Adamis
VEGF-initiated blood-retinal barrier breakdown in early diabetes.
Investigative ophthalmology & visual science 2001;42(10):2408-13.
2001: Viorica Pencea; KD Bingaman; Stanley J Wiegand; Marla B Luskin
Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(17):6706-17.
2001: Christine Wulff; Helen Wilson; John S Rudge; Stanley J Wiegand; SF Lunn; Hamish M Fraser
Luteal angiogenesis: prevention and intervention by treatment with vascular endothelial growth factor trap(A40).
The Journal of clinical endocrinology and metabolism 2001;86(7):3377-86.
2001: Christine Wulff; Stanley J Wiegand; Philippa Saunders; Graeme A Scobie; Hamish M Fraser
Angiogenesis during follicular development in the primate and its inhibition by treatment with truncated Flt-1-Fc (vascular endothelial growth factor Trap(A40)).
Endocrinology 2001;142(7):3244-54.
2001: PD Lambert; Keith D Anderson; Mark W Sleeman; V Wong; J Tan; A Hijarunguru; TL Corcoran; Jane D Murray; Karen Thabet; George D Yancopoulos; Stanley J Wiegand
Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4652-7.
2001: Susan D Croll; Stanley J Wiegand
Vascular growth factors in cerebral ischemia.
Molecular neurobiology 2001;23(2-3):121-35.
2000: George D Yancopoulos; S Davis; nicholas gale; John S Rudge; Stanley J Wiegand; Jocelyn Holash
Vascular-specific growth factors and blood vessel formation.
Nature 2000;407(6801):242-8.
2000: David Zagzag; David R Friedlander; Benjamin L Margolis; Martin Grumet; Gregg L Semenza; Hua Zhong; Jonathan W Simons; Jocelyn Holash; Stanley J Wiegand; George D Yancopoulos
Molecular events implicated in brain tumor angiogenesis and invasion.
Pediatric neurosurgery 2000;33(1):49-55.
2000: David Zagzag; R Amirnovin; M A Greco; Herman Yee; Jocelyn Holash; Stanley J Wiegand; Stephanie Zabski; George D Yancopoulos; Martin Grumet
Vascular apoptosis and involution in gliomas precede neovascularization: a novel concept for glioma growth and angiogenesis.
Laboratory investigation; a journal of technical methods and pathology 2000;80(6):837-49.
2000: W M Peterson; Q Wang; R Tzekova; Stanley J Wiegand
Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(11):4081-90.
2000: Mark W Sleeman; Keith D Anderson; PD Lambert; George D Yancopoulos; Stanley J Wiegand
The ciliary neurotrophic factor and its receptor, CNTFR alpha.
Pharmaceutica acta Helvetiae 2000;74(2-3):265-72.
1999: Susan D Croll; C R Chesnutt; N A Greene; RM Lindsay; Stanley J Wiegand
Peptide immunoreactivity in aged rat cortex and hippocampus as a function of memory and BDNF infusion.
Pharmacology, biochemistry, and behavior 1999;64(3):625-35.
1999: David Zagzag; A Hooper; David R Friedlander; Wai Chan; Jocelyn Holash; Stanley J Wiegand; George D Yancopoulos; Martin Grumet
In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis.
Experimental neurology 1999;159(2):391-400.
1999: Jocelyn Holash; Stanley J Wiegand; George D Yancopoulos
New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF.
Oncogene 1999;18(38):5356-62.
1999: Jocelyn Holash; Peter C Maisonpierre; D Compton; P Boland; C R Alexander; David Zagzag; George D Yancopoulos; Stanley J Wiegand
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.
Science (New York, N.Y.) 1999;284(5422):1994-8.
1999: JR Tonra; M Ono; X Liu; Karen Garcia; C Jackson; George D Yancopoulos; Stanley J Wiegand; V Wong
Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice.
Diabetes 1999;48(3):588-94.
1999: Susan D Croll; Chitra Suri; D L Compton; M V Simmons; George D Yancopoulos; RM Lindsay; Stanley J Wiegand; John S Rudge; Helen E Scharfman
Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex.
Neuroscience 1999;93(4):1491-506.
1998: Susan D Croll; N Y Ip; RM Lindsay; Stanley J Wiegand
Expression of BDNF and trkB as a function of age and cognitive performance.
Brain research 1998;812(1-2):200-8.
1998: David M Yurek; S B Hipkens; Stanley J Wiegand; CA Altar
Optimal effectiveness of BDNF for fetal nigral transplants coincides with the ontogenic appearance of BDNF in the striatum.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(15):6040-7.
1998: Susan D Croll; C R Chesnutt; John S Rudge; AL Acheson; Terence Edward Ryan; JA Siuciak; PS DiStefano; Stanley J Wiegand; RM Lindsay
Co-infusion with a TrkB-Fc receptor body carrier enhances BDNF distribution in the adult rat brain.
Experimental neurology 1998;152(1):20-33.
1998: T Zigova; Viorica Pencea; Stanley J Wiegand; Marla B Luskin
Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb.
Molecular and cellular neurosciences 1998;11(4):234-45.
1998: T Zigova; Viorica Pencea; Ranjita Betarbet; Stanley J Wiegand; C Alexander; Roy A E Bakay; Marla B Luskin
Neuronal progenitor cells of the neonatal subventricular zone differentiate and disperse following transplantation into the adult rat striatum.
Cell transplantation 1998;7(2):137-56.
1998: John S Rudge; P E Mather; Elizabeth Pasnikowski; Ning Cai; TL Corcoran; AL Acheson; K Anderson; RM Lindsay; Stanley J Wiegand
Endogenous BDNF protein is increased in adult rat hippocampus after a kainic acid induced excitotoxic insult but exogenous BDNF is not neuroprotective.
Experimental neurology 1998;149(2):398-410.
1998: TF Hsieh; S Simler; Marguerite Vergnes; Peter Gass; Christian Marescaux; Stanley J Wiegand; Manfred Zimmermann; Thomas Herdegen
BDNF restores the expression of Jun and Fos inducible transcription factors in the rat brain following repetitive electroconvulsive seizures.
Experimental neurology 1998;149(1):161-74.
1997: N R Kobayashi; D P Fan; Klaus M Giehl; AM Bedard; Stanley J Wiegand; Wolfram Tetzlaff
BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(24):9583-95.
1997: CA Altar; Ning Cai; T Bliven; M Juhasz; J M Conner; AL Acheson; RM Lindsay; Stanley J Wiegand
Anterograde transport of brain-derived neurotrophic factor and its role in the brain.
Nature 1997;389(6653):856-60.
1997: N Kawahara; Susan D Croll; Stanley J Wiegand; I Klatzo
Cortical spreading depression induces long-term alterations of BDNF levels in cortex and hippocampus distinct from lesion effects: implications for ischemic tolerance.
Neuroscience research 1997;29(1):37-47.
1997: Peter C Maisonpierre; Chitra Suri; Pam Jones; S Bartunkova; Stanley J Wiegand; Czeslaw Radziejewski; D Compton; Joyce McClain; Thomas H Aldrich; Nick Papadopoulos; Thomas J Daly; Samuel Davis; TN Sato; George D Yancopoulos
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.
Science (New York, N.Y.) 1997;277(5322):55-60.
1997: L Frank; Stanley J Wiegand; JA Siuciak; RM Lindsay; John S Rudge
Effects of BDNF infusion on the regulation of TrkB protein and message in adult rat brain.
Experimental neurology 1997;145(1):62-70.
1997: M E Helgren; KD Cliffer; K Torrento; C Cavnor; Rory Curtis; PS DiStefano; Stanley J Wiegand; RM Lindsay
Neurotrophin-3 administration attenuates deficits of pyridoxine-induced large-fiber sensory neuropathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(1):372-82.
1997: JA Siuciak; D R Lewis; Stanley J Wiegand; RM Lindsay
Antidepressant-like effect of brain-derived neurotrophic factor (BDNF).
Pharmacology, biochemistry, and behavior 1997;56(1):131-7.
1996: K D Anderson; N Panayotatos; T L Corcoran; RM Lindsay; Stanley J Wiegand
Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):7346-51.
1996: B E Jones; C B Boylan; M Fritsche; M Juhasz; C Jackson; Stanley J Wiegand; C Hyman; RM Lindsay; C A Altar
A continuous striatal infusion of 6-hydroxydopamine produces a terminal axotomy and delayed behavioral effects.
Brain research 1996;709(2):275-84.
1996: Ralph Alderson; Stanley J Wiegand; K D Anderson; Ning Cai; J Y Cho; RM Lindsay; C A Altar
Neurotrophin-4/5 maintains the cholinergic phenotype of axotomized septal neurons.
The European journal of neuroscience 1996;8(2):282-90.
1995: K D Anderson; Ralph Alderson; C A Altar; PS DiStefano; T L Corcoran; RM Lindsay; Stanley J Wiegand
Differential distribution of exogenous BDNF, NGF, and NT-3 in the brain corresponds to the relative abundance and distribution of high-affinity and low-affinity neurotrophin receptors.
The Journal of comparative neurology 1995;357(2):296-317.
1995: JA Siuciak; V Wong; D Pearsall; Stanley J Wiegand; RM Lindsay
BDNF produces analgesia in the formalin test and modifies neuropeptide levels in rat brain and spinal cord areas associated with nociception.
The European journal of neuroscience 1995;7(4):663-70.
1994: C A Altar; JA Siuciak; P Wright; Nancy Y Ip; RM Lindsay; Stanley J Wiegand
In situ hybridization of trkB and trkC receptor mRNA in rat forebrain and association with high-affinity binding of [125I]BDNF, [125I]NT-4/5 and [125I]NT-3.
The European journal of neuroscience 1994;6(9):1389-405.
1994: C A Altar; C B Boylan; M Fritsche; B E Jones; C Jackson; Stanley J Wiegand; RM Lindsay; C Hyman
Efficacy of brain-derived neurotrophic factor and neurotrophin-3 on neurochemical and behavioral deficits associated with partial nigrostriatal dopamine lesions.
Journal of neurochemistry 1994;63(3):1021-32.
1994: Susan D Croll; Stanley J Wiegand; K D Anderson; RM Lindsay; H Nawa
Regulation of neuropeptides in adult rat forebrain by the neurotrophins BDNF and NGF.
The European journal of neuroscience 1994;6(8):1343-53.
1994: John S Rudge; Y Li; E M Pasnikowski; K Mattsson; L Pan; George D Yancopoulos; Stanley J Wiegand; RM Lindsay; Nancy Y Ip
Neurotrophic factor receptors and their signal transduction capabilities in rat astrocytes.
The European journal of neuroscience 1994;6(5):693-705.
1994: RM Lindsay; Stanley J Wiegand; C A Altar; P S DiStefano
Neurotrophic factors: from molecule to man.
Trends in neurosciences 1994;17(5):182-90.
1994: JA Siuciak; C A Altar; Stanley J Wiegand; RM Lindsay
Antinociceptive effect of brain-derived neurotrophic factor and neurotrophin-3.
Brain research 1994;633(1-2):326-30.
1993: RM Lindsay; C A Altar; Jesse Cedarbaum; C Hyman; Stanley J Wiegand
The therapeutic potential of neurotrophic factors in the treatment of Parkinson's disease.
Experimental neurology 1993;124(1):103-18.
1993: J K Morse; Stanley J Wiegand; K Anderson; Y You; Ning Cai; J Carnahan; J Miller; PS DiStefano; C A Altar; RM Lindsay
Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(10):4146-56.
1993: Nancy Y Ip; Joyce McClain; N X Barrezueta; Thomas H Aldrich; L Pan; Y Li; Stanley J Wiegand; B Friedman; Samuel Davis; George D Yancopoulos
The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development.
Neuron 1993;10(1):89-102.
1993: Nancy Y Ip; Stanley J Wiegand; J Morse; John S Rudge
Injury-induced regulation of ciliary neurotrophic factor mRNA in the adult rat brain.
The European journal of neuroscience 1993;5(1):25-33.
1992: C A Altar; C B Boylan; C Jackson; S Hershenson; J Miller; Stanley J Wiegand; RM Lindsay; C Hyman
Brain-derived neurotrophic factor augments rotational behavior and nigrostriatal dopamine turnover in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11347-51.
1992: B Friedman; S S Scherer; John S Rudge; M Helgren; D Morrisey; Joyce McClain; D Y Wang; Stanley J Wiegand; Mark E Furth; RM Lindsay
Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo.
Neuron 1992;9(2):295-305.
1992: PS DiStefano; B Friedman; Czeslaw Radziejewski; C Alexander; P Boland; C M Schick; RM Lindsay; Stanley J Wiegand
The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons.
Neuron 1992;8(5):983-93.
1990: Peter C Maisonpierre; L Belluscio; B Friedman; Ralph Alderson; Stanley J Wiegand; Mark E Furth; RM Lindsay; George D Yancopoulos
NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression.
Neuron 1990;5(4):501-9.