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Beata Wielgus-Kutrowska

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Beata Wielgus-Kutrowska; Tsutomu Yokomatsu; Katarzyna Breer; Alicja Dyzma; Agnieszka Girstun; Mariko Hashimoto; Sadao Hikishima; Marta Narczyk; Krzysztof Staroń; Agnieszka Bzowska
Trimeric purine nucleoside phosphorylase: exploring postulated one-third-of-the-sites binding in the transition state.
Zoran Štefanić; Agnieszka Bzowska; Goran Mikleušević; Marta Narczyk; Beata Wielgus-Kutrowska; Marija Luić
New phosphate binding sites in the crystal structure of Escherichia coli purine nucleoside phosphorylase complexed with phosphate and formycin A.
Goran Mikleušević; Marta Narczyk; Zoran Stefanić; Beata Wielgus-Kutrowska; Agnieszka Bzowska; Marija Luić
Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies.

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2012: Beata Wielgus-Kutrowska; Tsutomu Yokomatsu; Katarzyna Breer; Alicja Dyzma; Agnieszka Girstun; Mariko Hashimoto; Sadao Hikishima; Marta Narczyk; Krzysztof Staroń; Agnieszka Bzowska
Trimeric purine nucleoside phosphorylase: exploring postulated one-third-of-the-sites binding in the transition state.
Bioorganic & medicinal chemistry 2012;20(22):6758-69.
2012: Zoran Štefanić; Agnieszka Bzowska; Goran Mikleušević; Marta Narczyk; Beata Wielgus-Kutrowska; Marija Luić
New phosphate binding sites in the crystal structure of Escherichia coli purine nucleoside phosphorylase complexed with phosphate and formycin A.
FEBS letters 2012;586(7):967-71.
2011: Goran Mikleušević; Marta Narczyk; Zoran Stefanić; Beata Wielgus-Kutrowska; Agnieszka Bzowska; Marija Luić
Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies.
Biochimie 2011;93(9):1610-22.
2010: Katarzyna Breer; Ljubica Glavas-Obrovac; Mirjana Suver; Sadao Hikishima; Mariko Hashimoto; Tsutomu Yokomatsu; Beata Wielgus-Kutrowska; Lucyna Magnowska; Agnieszka Bzowska
9-Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow-binding picomolar inhibitors of trimeric purine nucleoside phosphorylase.
The FEBS journal 2010;277(7):1747-60.
2010: Katarzyna Breer; Beata Wielgus-Kutrowska; Agnieszka Girstun; Krzysztof Staroń; Mariko Hashimoto; Sadao Hikishima; Tsutomu Yokomatsu; Agnieszka Bzowska
Overexpressed proteins may act as mops removing their ligands from the host cells: a case study of calf PNP.
Biochemical and biophysical research communications 2010;391(2):1203-9.
2010: Grzegorz Chojnowski; Katarzyna Breer; Marta Narczyk; Beata Wielgus-Kutrowska; Honorata Czapinska; Mariko Hashimoto; Sadao Hikishima; Tsutomu Yokomatsu; Matthias Bochtler; Agnieszka Girstun; Krzysztof Staroń; Agnieszka Bzowska
1.45 A resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state.
Biochemical and biophysical research communications 2010;391(1):703-8.
2008: Katarzyna Breer; Agnieszka Girstun; Beata Wielgus-Kutrowska; Krzysztof Staroń; Agnieszka Bzowska
Overexpression, purification and characterization of functional calf purine nucleoside phosphorylase (PNP).
Protein expression and purification 2008;61(2):122-30.
2008: Jan M Antosiewicz; Katarzyna Breer; Agnieszka Bzowska; Beata Wielgus-Kutrowska
On the analysis of fluorimetric titration curves of purine nucleoside phosphorylase.
Nucleic acids symposium series (2004) 2008;(52):671-2.
2008: Katarzyna Breer; Beata Wielgus-Kutrowska; Mariko Hashimoto; Sadao Hikishima; Tsutomu Yokomatsu; Roman H Szczepanowski; Matthias Bochtler; Agnieszka Girstun; Krzysztof Starón; Agnieszka Bzowska
Thermodynamic studies of interactions of calf spleen PNP with acyclic phosphonate inhibitors.
Nucleic acids symposium series (2004) 2008;(52):663-4.
2007: Beata Wielgus-Kutrowska; Jan M Antosiewicz; M Długosz; Antonín Holý; Agnieszka Bzowska
Towards the mechanism of trimeric purine nucleoside phosphorylases: stopped-flow studies of binding of multisubstrate analogue inhibitor - 2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine.
Biophysical chemistry 2007;125(2-3):260-8.
2007: Katarzyna Stepniak; Agnieszka Girstun; Beata Wielgus-Kutrowska; Krzysztof Staroń; Agnieszka Bzowska
Cloning, expression, purification, and some properties of calf purine nucleoside phosphorylase.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):855-9.
2007: Jan M Antosiewicz; Beata Wielgus-Kutrowska; Maciej Długosz; Antonin Holy; Agnieszka Bzowska
Kinetics of binding of multisubstrate analogue inhibitor (2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine) with trimeric purine nucleoside phosphorylase.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):969-74.
2006: Beata Wielgus-Kutrowska; Agnieszka Bzowska
Probing the mechanism of purine nucleoside phosphorylase by steady-state kinetic studies and ligand binding characterization determined by fluorimetric titrations.
Biochimica et biophysica acta 2006;1764(5):887-902.
2005: Beata Wielgus-Kutrowska; Agnieszka Bzowska
Kinetic properties of Cellulomonas sp. purine nucleoside phosphorylase with typical and non-typical substrates: implications for the reaction mechanism.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):471-6.
2004: Agnieszka Bzowska; Gertraud Koellner; Beata Wielgus-Kutrowska; Albrecht Stroh; Grzegorz Raszewski; Antonín Holý; Thomas Steiner; Joachim Frank
Crystal structure of calf spleen purine nucleoside phosphorylase with two full trimers in the asymmetric unit: important implications for the mechanism of catalysis.
Journal of molecular biology 2004;342(3):1015-32.
2003: Beata Wielgus-Kutrowska; Joachim Frank; Antonín Holý; Gertraud Koellner; Agnieszka Bzowska
Interactions of trimeric purine nucleoside phosphorylases with ground state analogues--calorimetric and fluorimetric studies.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1695-8.
2002: Beata Wielgus-Kutrowska; Agnieszka Bzowska; Jan Tebbe; Gertraud Koellner; David Shugar
Purine nucleoside phosphorylase from Cellulomonas sp.: physicochemical properties and binding of substrates determined by ligand-dependent enhancement of enzyme intrinsic fluorescence, and by protective effects of ligands on thermal inactivation of the enzyme.
Biochimica et biophysica acta 2002;1597(2):320-34.
2002: Gertraud Koellner; Agnieszka Bzowska; Beata Wielgus-Kutrowska; Marija Luić; Thomas Steiner; Wolfram Saenger; Janusz Stepiński
Open and closed conformation of the E. coli purine nucleoside phosphorylase active center and implications for the catalytic mechanism.
Journal of molecular biology 2002;315(3):351-71.
1999: Jan Tebbe; Agnieszka Bzowska; Beata Wielgus-Kutrowska; Werner Schröder; Zygmunt Kazimierczuk; David Shugar; Wolfram Saenger; Gertraud Koellner
Crystal structure of the purine nucleoside phosphorylase (PNP) from Cellulomonas sp. and its implication for the mechanism of trimeric PNPs.
Journal of molecular biology 1999;294(5):1239-55.
1998: Agnieszka Bzowska; Jan Tebbe; M Luić; Beata Wielgus-Kutrowska; Werner Schröder; David Shugar; Wolfram Saenger; Gertraud Koellner
Crystallization and preliminary X-ray studies of purine nucleoside phosphorylase from Cellulomonas sp.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 5):1061-3.
1998: Beata Wielgus-Kutrowska; Jan Tebbe; Werner Schröder; Marija Luic; David Shugar; Wolfram Saenger; Gertraud Koellner; Agnieszka Bzowska
Cellulomonas sp. purine nucleoside phosphorylase (PNP). Comparison with human and E. coli enzymes.
Advances in experimental medicine and biology 1998;431():259-64.
1997: Beata Wielgus-Kutrowska; Ewa Kulikowska; Jacek Wierzchowski; Agnieszka Bzowska; David Shugar
Nicotinamide riboside, an unusual, non-typical, substrate of purified purine-nucleoside phosphorylases.
European journal of biochemistry / FEBS 1997;243(1-2):408-14.
1996: J Wierzchowski; Beata Wielgus-Kutrowska; David Shugar
Fluorescence emission properties of 8-azapurines and their nucleosides, and application to the kinetics of the reverse synthetic reaction of purine nucleoside phosphorylase.
Biochimica et biophysica acta 1996;1290(1):9-17.