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Monika Wierdl

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Xiaozhen Yu; Monika Wierdl; Steven R Gwaltney; Delwar Hossain; Philip M Potter; Sara C Sigler; Randy M Wadkins
Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism.
Andrew C Hemmert; Tamara C Otto; Roberto A Chica; Monika Wierdl; Jonathan S Edwards; Steven L Lewis; Carol C Edwards; Lyudmila Tsurkan; C Linn Cadieux; Shane A Kasten; John R Cashman; Stephen L Mayo; Philip Potter; Douglas M Cerasoli; Steven M Lewis; Matthew R Redinbo
Nerve agent hydrolysis activity designed into a human drug metabolism enzyme.
Andrew C Hemmert; Tamara C Otto; Monika Wierdl; Carol C Edwards; Christopher D Fleming; Mary MacDonald; John R Cashman; Philip Potter; Douglas M Cerasoli; Matthew R Redinbo
Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin.

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All Publications

2012: Xiaozhen Yu; Monika Wierdl; Steven R Gwaltney; Delwar Hossain; Philip M Potter; Sara C Sigler; Randy M Wadkins
Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism.
Journal of molecular modeling 2012;18(6):2869-83.
2011: Andrew C Hemmert; Tamara C Otto; Roberto A Chica; Monika Wierdl; Jonathan S Edwards; Steven L Lewis; Carol C Edwards; Lyudmila Tsurkan; C Linn Cadieux; Shane A Kasten; John R Cashman; Stephen L Mayo; Philip Potter; Douglas M Cerasoli; Steven M Lewis; Matthew R Redinbo
Nerve agent hydrolysis activity designed into a human drug metabolism enzyme.
PloS one 2011;6(3):e17441.
2010: Andrew C Hemmert; Tamara C Otto; Monika Wierdl; Carol C Edwards; Christopher D Fleming; Mary MacDonald; John R Cashman; Philip Potter; Douglas M Cerasoli; Matthew R Redinbo
Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin.
Molecular pharmacology 2010;77(4):508-16.
2008: Jason M Hatfield; Monika Wierdl; Randy M Wadkins; Philip Potter
Modifications of human carboxylesterase for improved prodrug activation.
Expert opinion on drug metabolism & toxicology 2008;4(9):1153-65.
2008: Monika Wierdl; Lyudmila Tsurkan; Janice L Hyatt; Carol C Edwards; M Jason Hatfield; Christopher L Morton; Peter J Houghton; Mary K Danks; Matthew R Redinbo; Philip Potter
An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11.
Cancer gene therapy 2008;15(3):183-92.
2008: Timothy M Streit; Abdolsamad Borazjani; Shellaine E Lentz; Monika Wierdl; Philip Potter; Steven R Gwaltney; Matthew K Ross
Evaluation of the 'side door' in carboxylesterase-mediated catalysis and inhibition.
Biological chemistry 2008;389(2):149-62.
2007: Latorya D Hicks; Janice L Hyatt; Teri Moak; Carol C Edwards; Lyudmila Tsurkan; Monika Wierdl; Antonio M Ferreira; Randy M Wadkins; Philip Potter
Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Bioorganic & medicinal chemistry 2007;15(11):3801-17.
2007: Janice L Hyatt; Teri Moak; M Jason Hatfield; Lyudmila Tsurkan; Carol C Edwards; Monika Wierdl; Mary K Danks; Randy M Wadkins; Philip Potter
Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Journal of medicinal chemistry 2007;50(8):1876-85.
2007: Mary K Danks; Kyoung Jin P Yoon; Rebecca A Bush; Joanna S Remack; Monika Wierdl; Lyudmila Tsurkan; Seung Kim; Elizabeth Garcia; Marianne Z Metz; Joseph Najbauer; Philip Potter; Karen S Aboody
Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma.
Cancer research 2007;67(1):22-5.
2006: Janice L Hyatt; Lyudmila Tsurkan; Monika Wierdl; Carol C Edwards; Mary K Danks; Philip Potter
Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity.
Molecular cancer therapeutics 2006;5(9):2281-8.
2005: Janice L Hyatt; Vanessa Stacy; Randy M Wadkins; Kyoung Jin P Yoon; Monika Wierdl; Carol C Edwards; Matthias Zeller; Allen D Hunter; Mary K Danks; Guy Crundwell; Philip Potter
Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.
Journal of medicinal chemistry 2005;48(17):5543-50.
2005: Monika Wierdl; Philip Potter
Update on gene therapy approaches for cancer.
Current hematology reports 2005;4(4):294-9.
2005: Randy M Wadkins; Janice L Hyatt; Xin Wei; Kyoung Jin P Yoon; Monika Wierdl; Carol C Edwards; Christopher L Morton; John C Obenauer; Komath Damodaran; Paul Beroza; Mary K Danks; Philip Potter
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Journal of medicinal chemistry 2005;48(8):2906-15.
2004: Monika Wierdl; Christopher L Morton; Nathan K Nguyen; Matthew R Redinbo; Philip Potter
Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model.
Biochemistry 2004;43(7):1874-82.
2003: Monika Wierdl; Amelia Wall; Christopher L Morton; Janardhan Sampath; Mary K Danks; John D Schuetz; Philip Potter
Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance.
Molecular pharmacology 2003;64(2):279-88.
2003: Monika Wierdl; Christopher L Morton; Linda C Harris; Mary K Danks; John D Schuetz; Philip Potter
p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11).
The Journal of pharmacology and experimental therapeutics 2003;304(2):699-705.
2001: Randy M Wadkins; Christopher L Morton; J K Weeks; L Oliver; Monika Wierdl; Mary K Danks; Philip Potter
Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases.
Molecular pharmacology 2001;60(2):355-62.
2001: M M Meck; Monika Wierdl; Lars M Wagner; Rebecca A Burger; Sylvie M Guichard; Erik J Krull; Linda C Harris; Philip Potter; Mary K Danks
A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11.
Cancer research 2001;61(13):5083-9.
2001: Monika Wierdl; Christopher L Morton; J K Weeks; Mary K Danks; Linda C Harris; Philip Potter
Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase.
Cancer research 2001;61(13):5078-82.
2000: Christopher L Morton; Monika Wierdl; L Oliver; Margaret K Ma; Mary K Danks; Clinton F Stewart; Julie L Eiseman; Philip Potter
Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase.
Cancer research 2000;60(15):4206-10.
2000: Monika Wierdl; Christopher L Morton; Mary K Danks; Philip Potter
Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation.
Biochemical pharmacology 2000;59(7):773-81.
1998: Philip Potter; JS Wolverton; Christopher L Morton; Monika Wierdl; Mary K Danks
Cellular localization domains of a rabbit and a human carboxylesterase: influence on irinotecan (CPT-11) metabolism by the rabbit enzyme.
Cancer research 1998;58(16):3627-32.