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Nils Wierup

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E Banke; M Riva; L Shcherbina; Nils Wierup; Eva Degerman
Cocaine- and amphetamine-regulated transcript is expressed in adipocytes and regulate lipid- and glucose homeostasis.
Ramasri Sathanoori; David Erlinge; Olga Göransson; Björn Olde; Nils Wierup
Cocaine- and amphetamine-regulated transcript (CART) protects beta cells against glucotoxicity and increases cell proliferation.
Marloes Dekker Nitert; Hemang Parikh; Tina Rönn; Peter Volkov; Holger Weishaupt; Ylva Wessman; Nils Wierup; Beatrice T Yang; Mia Abels; Peter Almgren; Joanne Attema; Tasnim Dayeh; Targ Elgzyri; Karl-Fredrik Eriksson; Leif Groop; Elin Hall; Ola Hansson; Per-Anders Jansson; Stefan Lang; Emma Nilsson; Charlotte Ling
Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes.

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All Publications

2013: E Banke; M Riva; L Shcherbina; Nils Wierup; Eva Degerman
Cocaine- and amphetamine-regulated transcript is expressed in adipocytes and regulate lipid- and glucose homeostasis.
Regulatory peptides 2013;182():35-40.
2013: Ramasri Sathanoori; David Erlinge; Olga Göransson; Björn Olde; Nils Wierup
Cocaine- and amphetamine-regulated transcript (CART) protects beta cells against glucotoxicity and increases cell proliferation.
The Journal of biological chemistry 2013;288(5):3208-18.
2012: Marloes Dekker Nitert; Hemang Parikh; Tina Rönn; Peter Volkov; Holger Weishaupt; Ylva Wessman; Nils Wierup; Beatrice T Yang; Mia Abels; Peter Almgren; Joanne Attema; Tasnim Dayeh; Targ Elgzyri; Karl-Fredrik Eriksson; Leif Groop; Elin Hall; Ola Hansson; Per-Anders Jansson; Stefan Lang; Emma Nilsson; Charlotte Ling
Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes.
Diabetes 2012;61(12):3322-32.
2012: Kalle Landerholm; Liliya Shcherbina; Sture Emil Falkmer; Johannes Järhult; Nils Wierup
Expression of cocaine- and amphetamine-regulated transcript is associated with worse survival in small bowel carcinoid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(13):3668-76.
2012: Samina Asad; Hedvig Bennet; Annelie Carlsson; Malin Fex; Gun Forsander; Alexandra Gyllenberg; Ola Hansson; Sten-Anders Ivarsson; Helena Larsson; Bengt Lindblad; Johnny Ludvigsson; Holger Luthman; Claude Marcus; Jan Nerup; Pernilla Nikamo; Flemming Pociot; Kjersti S Rønningen; Nils Wierup; Ake Lernmark; Ingrid Kockum
HTR1A a novel type 1 diabetes susceptibility gene on chromosome 5p13-q13.
PloS one 2012;7(5):e35439.
2011: Jorien M M van der Burg; Annika Winqvist; N Ahmad Aziz; Gillian P Bates; Maria Björkqvist; Patrik Brundin; Marion L C Maat-Schieman; Raymund A C Roos; Nils Wierup
Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice.
Neurobiology of disease 2011;44(1):1-8.
2011: Cecilia L F Nagorny; Ramasri Sathanoori; Ulrikke Voss; Hindrik Mulder; Nils Wierup
Distribution of melatonin receptors in murine pancreatic islets.
Journal of pineal research 2011;50(4):412-7.
2011: Mardjaneh Karbalaei Sadegh; Mari Ekman; Catarina Rippe; Frank Sundler; Nils Wierup; Michiko Mori; Bengt Uvelius; Karl Swärd
Biomechanical properties and innervation of the female caveolin-1-deficient detrusor.
British journal of pharmacology 2011;162(5):1156-70.
2010: Jonatan Ahrén; Bo Ahrén; Nils Wierup
Increased β-cell volume in mice fed a high-fat diet: a dynamic study over 12 months.
Islets 2010;2(6):353-6.
2010: Ulrika Andersson; L Rosén; Nils Wierup; Elin M Ostman; Inger M E Björck; Cecilia Holm
A low glycaemic diet improves oral glucose tolerance but has no effect on β-cell function in C57BL/6J mice.
Diabetes, obesity & metabolism 2010;12(11):976-82.
2010: Camilla Ringström; Marloes Dekker Nitert; Hedvig Bennet; Malin Fex; Philippe Valet; Jens F Rehfeld; Lennart Friis-Hansen; Nils Wierup
Apelin is a novel islet peptide.
Regulatory peptides 2010;162(1-3):44-51.
2010: Jenny Johansson; Ulrikke Voss; Gokul Kesavan; Igor Kostetskii; Nils Wierup; Glenn L Radice; Henrik Semb
N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover.
Genesis (New York, N.Y. : 2000) 2010;48(6):374-81.
2010: Ulrika Andersson; Liza Rosén; Elin M Ostman; Kristoffer Ström; Nils Wierup; Inger M E Björck; Cecilia Holm
Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse.
Nutrition (Burbank, Los Angeles County, Calif.) 2010;26(2):230-9.
2009: Jörgen Borg; Cecilia Klint; Nils Wierup; Kristoffer Ström; Sara Larsson; Frank Sundler; ROBERTO LUPI; Piero Marchetti; Guoheng Xu; Alan Kimmel; Constantine Londos; Cecilia Holm
Perilipin is present in islets of Langerhans and protects against lipotoxicity when overexpressed in the beta-cell line INS-1.
Endocrinology 2009;150(7):3049-57.
2009: Karin Berger; Rebecka Lindh; Nils Wierup; Emilia Zmuda-Trzebiatowska; Andreas Lindqvist; Vincent C Manganiello; Eva Degerman
Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism.
PloS one 2009;4(3):e4671.
2008: Sara Larsson; Nils Wierup; Frank Sundler; Lena Eliasson; Cecilia Holm
Lack of cholesterol mobilization in islets of hormone-sensitive lipase deficient mice impairs insulin secretion.
Biochemical and biophysical research communications 2008;376(3):558-62.
2008: Björn Lindkvist; Nils Wierup; Frank Sundler; Anders Borgström
Long-term nicotine exposure causes increased concentrations of trypsinogens and amylase in pancreatic extracts in the rat.
Pancreas 2008;37(3):288-94.
2008: Karl Bacos; Maria Björkqvist; Asa Petersén; Lena Luts; Marion L C Maat-Schieman; Raymund A C Roos; Frank Sundler; Patrik Brundin; Hindrik Mulder; Nils Wierup
Islet beta-cell area and hormone expression are unaltered in Huntington's disease.
Histochemistry and cell biology 2008;129(5):623-9.
2008: Jorien M M van der Burg; Karl Bacos; Nigel I Wood; Andreas Lindqvist; Nils Wierup; Ben Woodman; Jaclyn I Wamsteeker; Ruben Smith; Tomas Deierborg; Michael J Kuhar; Gillian P Bates; Hindrik Mulder; Charlotte Erlanson-Albertsson; A Jennifer Morton; Patrik Brundin; Asa Petersén; Maria Björkqvist
Increased metabolism in the R6/2 mouse model of Huntington's disease.
Neurobiology of disease 2008;29(1):41-51.
2007: Bo Ahrén; Maria Sörhede Winzell; Nils Wierup; Frank Sundler; Bryan Burkey; Thomas Hughes
DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide.
Regulatory peptides 2007;143(1-3):97-103.
2007: Malin Fex; Nils Wierup; Marloes Dekker Nitert; Michael Ristow; Hindrik Mulder
Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance.
The Journal of endocrinology 2007;194(3):551-5.
2007: Nils Wierup; Maria Björkqvist; Björn Weström; Stefan G Pierzynowski; Frank Sundler; Kristina Sjölund
Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestine.
The Journal of clinical endocrinology and metabolism 2007;92(9):3573-81.
2007: Maria Sörhede Winzell; Christian L Brand; Nils Wierup; Ulla G Sidelmann; Frank Sundler; Erica Nishimura; B Ahrén
Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet.
Diabetologia 2007;50(7):1453-62.
2007: Helena A Walz; Nils Wierup; Jenny Vikman; Vincent C Manganiello; Eva Degerman; Lena Eliasson; Lena Stenson Holst
Beta-cell PDE3B regulates Ca2+-stimulated exocytosis of insulin.
Cellular signalling 2007;19(7):1505-13.
2007: Anna Gunnarsdóttir; Nils Wierup; Lars-Torsten Larsson; Michael J Kuhar; Eva Ekblad
CART-peptide immunoreactivity in enteric nerves in patients with Hirschsprung's disease.
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie 2007;17(3):184-9.
2007: Frida Fåk; Lennart Friis-Hansen; Björn Weström; Nils Wierup
Gastric ghrelin cell development is hampered and plasma ghrelin is reduced by delayed weaning in rats.
The Journal of endocrinology 2007;192(2):345-52.
2007: Nils Wierup; Anna Gunnarsdóttir; Eva Ekblad; Frank Sundler
Characterisation of CART-containing neurons and cells in the porcine pancreas, gastro-intestinal tract, adrenal and thyroid glands.
BMC neuroscience 2007;8():51.
2007: Dorte X Gram; Bo Ahrén; Istvan Nagy; Uffe B Olsen; Christian L Brand; Frank Sundler; René Tabanera; Ove Svendsen; Richard D Carr; Peter Santha; Nils Wierup; Anders J Hansen
Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes.
The European journal of neuroscience 2007;25(1):213-23.
2007: Malin Fex; Marloes Dekker Nitert; Nils Wierup; Frank Sundler; C Ling; Hindrik Mulder
Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet.
Diabetologia 2007;50(1):74-83.
2006: Nils Wierup; Frank Sundler
CART is a novel islet regulatory peptide.
Peptides 2006;27(8):2031-6.
2006: Ola Hansson; Kristoffer Ström; Nuray Güner; Nils Wierup; Frank Sundler; Peter Höglund; Cecilia Holm
Inflammatory response in white adipose tissue in the non-obese hormone-sensitive lipase null mouse model.
Journal of proteome research 2006;5(7):1701-10.
2006: Helena A Walz; Linda Härndahl; Nils Wierup; Emilia Zmuda-Trzebiatowska; Fredrik Svennelid; Vincent C Manganiello; Thorkil Ploug; Frank Sundler; Eva Degerman; Bo Ahrén; Lena Stenson Holst
Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B.
The Journal of endocrinology 2006;189(3):629-41.
2006: Nils Wierup; Maria Björkqvist; Michael J Kuhar; Hindrik Mulder; Frank Sundler
CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats.
Diabetes 2006;55(2):305-11.
2006: Tommy Jönsson; Bo Ahrén; Giovanni Pacini; Frank Sundler; Nils Wierup; Stig Steen; Trygve Sjöberg; Martin Ugander; Johan Frostegård; Leif Göransson; Staffan Lindeberg
A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs.
Nutrition & metabolism 2006;3():39.
2005: Lennart Friis-Hansen; Nils Wierup; Jens F Rehfeld; Frank Sundler
Reduced ghrelin, islet amyloid polypeptide, and peptide YY expression in the stomach of gastrin-cholecystokinin knockout mice.
Endocrinology 2005;146(10):4464-71.
2005: Lennart Friis-Hansen; Nils Wierup; Jens F Rehfeld; Frank Sundler
Antral G-cell in gastrin and gastrin-cholecystokinin knockout animals.
Cell and tissue research 2005;321(1):141-6.
2005: Nils Wierup; Frank Sundler
Ultrastructure of islet ghrelin cells in the human fetus.
Cell and tissue research 2005;319(3):423-8.
2005: Maria Björkqvist; Malin Fex; Erik Renström; Nils Wierup; Asa Petersén; Joana Gil; Karl Bacos; Natalija Popovic; Jia-Yi Li; Frank Sundler; Patrik Brundin; Hindrik Mulder
The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis.
Human molecular genetics 2005;14(5):565-74.
2005: Asa Petersén; Joana Gil; Marion L C Maat-Schieman; Maria Björkqvist; Heikki Tanila; Inês M Araújo; Ruben Smith; Natalija Popovic; Nils Wierup; Per Norlén; Jia-Yi Li; Raymund A C Roos; Frank Sundler; Hindrik Mulder; Patrik Brundin
Orexin loss in Huntington's disease.
Human molecular genetics 2005;14(1):39-47.
2004: Bo Ahrén; Giovanni Pacini; David Wynick; Nils Wierup; Frank Sundler
Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice.
Endocrinology 2004;145(7):3190-6.
2004: Linda Härndahl; Nils Wierup; Sven Enerbäck; Hindrik Mulder; Vincent C Manganiello; Frank Sundler; Eva Degerman; Bo Ahrén; Lena Stenson Holst
Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology.
The Journal of biological chemistry 2004;279(15):15214-22.
2004: Nils Wierup; S Yang; R J McEvilly; Hindrik Mulder; F Sundler
Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(3):301-10.
2004: Nils Wierup; Michael J Kuhar; Bengt-Olof Nilsson; Hindrik Mulder; Eva Ekblad; F Sundler
Cocaine- and amphetamine-regulated transcript (CART) is expressed in several islet cell types during rat development.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(2):169-77.
2003: Eva Ekblad; Michael J Kuhar; Nils Wierup; F Sundler
Cocaine- and amphetamine-regulated transcript: distribution and function in rat gastrointestinal tract.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2003;15(5):545-57.
2002: Nils Wierup; H Svensson; Hindrik Mulder; Frank Sundler
The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas.
Regulatory peptides 2002;107(1-3):63-9.