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Thomas Wight

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Carole L Wilson; Thomas N Wight; Kathleen R Braun; Christina K Chan; Cindy A Chang; Michael T Chin; Jeremy M Frey; Peter J Gough; Yonggang Liu; Elaine W Raines
Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults.
Andrew G Ayars; Susan Potter-Perigo; Katherine Radford; Thomas N Wight; Leonard C Altman; Parameswaran Nair
Sputum hyaluronan and versican in severe eosinophilic asthma.
May J Reed; Christina K Chan; Mamatha Damodarasamy; Matthew N R Johnson; Thomas N Wight; Robert B Vernon
Cleavage of hyaluronan is impaired in aged dermal wounds.

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2013: Carole L Wilson; Thomas N Wight; Kathleen R Braun; Christina K Chan; Cindy A Chang; Michael T Chin; Jeremy M Frey; Peter J Gough; Yonggang Liu; Elaine W Raines
Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults.
Mechanisms of development 2013;130(4-5):272-89.
2013: Andrew G Ayars; Susan Potter-Perigo; Katherine Radford; Thomas N Wight; Leonard C Altman; Parameswaran Nair
Sputum hyaluronan and versican in severe eosinophilic asthma.
International archives of allergy and immunology 2013;161(1):65-73.
2013: May J Reed; Christina K Chan; Mamatha Damodarasamy; Matthew N R Johnson; Thomas N Wight; Robert B Vernon
Cleavage of hyaluronan is impaired in aged dermal wounds.
Matrix biology : journal of the International Society for Matrix Biology 2013;32(1):45-51.
2012: Rebecca L Hull; Pamela Y Johnson; Kathleen R Braun; Anthony J Day; Thomas N Wight
Hyaluronan and hyaluronan binding proteins are normal components of mouse pancreatic islets and are differentially expressed by islet endocrine cell types.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2012;60(10):749-60.
2012: Paul L Bollyky; Rebecca L Hull; Marika Bogdani; Jennifer B Bollyky; Thomas N Wight
The role of hyaluronan and the extracellular matrix in islet inflammation and immune regulation.
Current diabetes reports 2012;12(5):471-80.
2012: Jenny E Kanter; Farah Kramer; Lei O Li; Subramaniam Pennathur; Susan Potter-Perigo; Srinath Sanda; Charles N Serhan; Thad Vickery; Anuradha Vivekanandan-Giri; Thomas N Wight; Wei Yuan; Michelle M Averill; Shelley Barnhart; Lev Becker; Kathleen R Braun; Alan Chait; Rosalind A Coleman; Jay W Heinecke; Karin E Bornfeldt
Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(12):E715-24.
2012: Steven P Evanko; Gerald T Nepom; Susan Potter-Perigo; Paul L Bollyky; Thomas N Wight
Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration.
Matrix biology : journal of the International Society for Matrix Biology 2012;31(2):90-100.
2011: Tsuyoshi Chiba; Mary Y Chang; Shari Wang; Thomas N Wight; Timothy S McMillen; John F Oram; Tomas Vaisar; Jay W Heinecke; Frederick C De Beer; Maria C De Beer; Alan Chait
Serum amyloid A facilitates the binding of high-density lipoprotein from mice injected with lipopolysaccharide to vascular proteoglycans.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(6):1326-32.
2011: Mervyn J Merrilees; Brent W Beaumont; Kathleen R Braun; Anita C Thomas; Inkyung Kang; Aleksander Hinek; Alberto Passi; Thomas N Wight
Neointima formed by arterial smooth muscle cells expressing versican variant V3 is resistant to lipid and macrophage accumulation.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(6):1309-16.
2010: Ick-Mo Chung; Junwoo Kim; Youngmi K Pak; Yangsoo Jang; Woo Ick Yang; Innoc Han; Seung-Jung Park; Seong-Wook Park; jooryung huh; Thomas N Wight; Hikaru Ueno
Blockade of TGF-β by catheter-based local intravascular gene delivery does not alter the in-stent neointimal response, but enhances inflammation in pig coronary arteries.
International journal of cardiology 2010;145(3):468-75.
2010: Christina K Chan; Marsha W Rolle; Susan Potter-Perigo; Kathleen R Braun; Benjamin P Van Biber; Michael A Laflamme; Charles E Murry; Thomas N Wight
Differentiation of cardiomyocytes from human embryonic stem cells is accompanied by changes in the extracellular matrix production of versican and hyaluronan.
Journal of cellular biochemistry 2010;111(3):585-96.
2010: Susan Potter-Perigo; Pamela Y Johnson; Steven P Evanko; Christina K Chan; Kathleen R Braun; Thomas S Wilkinson; Leonard C Altman; Thomas N Wight
Polyinosine-polycytidylic acid stimulates versican accumulation in the extracellular matrix promoting monocyte adhesion.
American journal of respiratory cell and molecular biology 2010;43(1):109-20.
2010: Chang Yeop Han; Atil Kargi; Mohamed Omer; Christina K Chan; Martin Wabitsch; Kevin D O'Brien; Thomas N Wight; Alan Chait
Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation.
Diabetes 2010;59(2):386-96.
2010: Paul A Keire; Nicolas L'Heureux; Robert B Vernon; Mervyn J Merrilees; Barry Starcher; Elena Okon; Nathalie Dusserre; Todd N McAllister; Thomas N Wight
Expression of versican isoform V3 in the absence of ascorbate improves elastogenesis in engineered vascular constructs.
Tissue engineering. Part A 2010;16(2):501-12.
2009: David D Allison; Kathleen R Braun; Thomas N Wight; K Jane Grande-Allen
Differential effects of exogenous and endogenous hyaluronan on contraction and strength of collagen gels.
Acta biomaterialia 2009;5(4):1019-26.
2009: Lawrence True; Sarah Hawley; Thomas H Norwood; Kathleen R Braun; SP Evanko; Christina K Chan; Richard G LeBaron; Thomas N Wight
The accumulation of versican in the nodules of benign prostatic hyperplasia.
The Prostate 2009;69(2):149-58.
2009: Jo Nadine Fleming; Howard M Shulman; Richard A Nash; Pamela Y Johnson; Thomas N Wight; Allen Gown; Stephen M Schwartz
Cutaneous chronic graft-versus-host disease does not have the abnormal endothelial phenotype or vascular rarefaction characteristic of systemic sclerosis.
PloS one 2009;4(7):e6203.
2008: Jin-Yong Hwang; Pamela Y Johnson; Kathleen R Braun; Aleksander Hinek; Jens W Fischer; Kevin D O'Brien; Barry Starcher; Alexander W Clowes; Mervyn J Merrilees; Thomas N Wight
Retrovirally mediated overexpression of glycosaminoglycan-deficient biglycan in arterial smooth muscle cells induces tropoelastin synthesis and elastic fiber formation in vitro and in neointimae after vascular injury.
The American journal of pathology 2008;173(6):1919-28.
2008: Karin Tran-Lundmark; Phan-Kiet Tran; Gabrielle Paulsson-Berne; Vincent Fridén; Raija Soininen; Karl Tryggvason; Thomas N Wight; Michael G Kinsella; Jan Borén; Ulf Hedin
Heparan sulfate in perlecan promotes mouse atherosclerosis: roles in lipid permeability, lipid retention, and smooth muscle cell proliferation.
Circulation research 2008;103(1):43-52.
2008: Julie Nigro; Susan Potter-Perigo; Melanie E Ivey; Stephanie T de Dios; Stephen P Evanko; Thomas N Wight; Peter Little
The effect of PPAR ligands to modulate glucose metabolism alters the incorporation of metabolic precursors into proteoglycans synthesized by human vascular smooth muscle cells.
Archives of physiology and biochemistry 2008;114(3):171-7.
2008: David D Allison; Thomas N Wight; Nicolas J Ripp; Kathleen R Braun; K Jane Grande-Allen
Endogenous overexpression of hyaluronan synthases within dynamically cultured collagen gels: Implications for vascular and valvular disease.
Biomaterials 2008;29(20):2969-76.
2008: Thomas N Wight
Arterial remodeling in vascular disease: a key role for hyaluronan and versican.
Frontiers in bioscience : a journal and virtual library 2008;13():4933-7.
2008: Mervyn J Merrilees; Pamela S T Ching; Brent W Beaumont; Aleksander Hinek; Thomas N Wight; Peter N Black
Changes in elastin, elastin binding protein and versican in alveoli in chronic obstructive pulmonary disease.
Respiratory research 2008;9():41.
2007: David D Allison; Natalia Vasco; Kathleen R Braun; Thomas N Wight; K Jane Grande-Allen
The effect of endogenous overexpression of hyaluronan synthases on material, morphological, and biochemical properties of uncrosslinked collagen biomaterials.
Biomaterials 2007;28(36):5509-17.
2007: Thomas O McDonald; Ross G Gerrity; Christy Jen; Hao-Ji Chen; Kathleen Wark; Thomas N Wight; Alan Chait; Kevin D O'Brien
Diabetes and arterial extracellular matrix changes in a porcine model of atherosclerosis.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007;55(11):1149-57.
2007: Ebele C Chira; Timothy S McMillen; Shari Wang; Antonio Haw; Kevin D O'Brien; Thomas N Wight; Alan Chait
Tesaglitazar, a dual peroxisome proliferator-activated receptor alpha/gamma agonist, reduces atherosclerosis in female low density lipoprotein receptor deficient mice.
Atherosclerosis 2007;195(1):100-9.
2007: Yann Gouëffic; Susan Potter-Perigo; Christina K Chan; Pamela Y Johnson; Kathleen Braun; Steven P Evanko; Thomas N Wight
Sirolimus blocks the accumulation of hyaluronan (HA) by arterial smooth muscle cells and reduces monocyte adhesion to the ECM.
Atherosclerosis 2007;195(1):23-30.
2007: Chang Yeop Han; Savitha Subramanian; Christina K Chan; Mohamed Omer; Tsuyoshi Chiba; Thomas N Wight; Alan Chait
Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion.
Diabetes 2007;56(9):2260-73.
2007: Joan M Lemire; Christina K Chan; Steven Bressler; John Miller; Richard G LeBaron; Thomas N Wight
Interleukin-1beta selectively decreases the synthesis of versican by arterial smooth muscle cells.
Journal of cellular biochemistry 2007;101(3):753-66.
2007: Pamela Y Johnson; Susan Potter-Perigo; Michel D Gooden; Robert B Vernon; Thomas N Wight
Decorin synthesized by arterial smooth muscle cells is retained in fibrin gels and modulates fibrin contraction.
Journal of cellular biochemistry 2007;101(2):281-94.
2006: Lisa R Tannock; Elizabeth A Kirk; Victoria L King; Renée C LeBoeuf; Thomas N Wight; Alan Chait
Glucosamine supplementation accelerates early but not late atherosclerosis in LDL receptor-deficient mice.
The Journal of nutrition 2006;136(11):2856-61.
2006: Millicent M Sullivan; Thomas Barker; Sarah E Funk; Ari Karchin; Neungseon Seo; Magnus Höök; Joan Sanders; Barry Starcher; Thomas N Wight; Pauli Puolakkainen; E Helene Sage
Matricellular hevin regulates decorin production and collagen assembly.
The Journal of biological chemistry 2006;281(37):27621-32.
2006: Richard D Kenagy; Anna Plaas; Thomas N Wight
Versican degradation and vascular disease.
Trends in cardiovascular medicine 2006;16(6):209-15.
2006: Hannu Järveläinen; Pauli Puolakkainen; Sari Pakkanen; Eric L Brown; Magnus Höök; Renato V Iozzo; E Helene Sage; Thomas N Wight
A role for decorin in cutaneous wound healing and angiogenesis.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2006;14(4):443-52.
2006: Goro Otsuka; Ramtin Agah; Andrew D Frutkin; Thomas N Wight; David A Dichek
Transforming growth factor beta 1 induces neointima formation through plasminogen activator inhibitor-1-dependent pathways.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):737-43.
2006: Mary Y Chang; Chang Yeop Han; Thomas N Wight; Alan Chait
Antioxidants inhibit the ability of lysophosphatidylcholine to regulate proteoglycan synthesis.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(3):494-500.
2006: Robert Huang; Mervyn J Merrilees; Kathleen Braun; Brent W Beaumont; Joan M Lemire; Alexander W Clowes; Aleksander Hinek; Thomas N Wight
Inhibition of versican synthesis by antisense alters smooth muscle cell phenotype and induces elastic fiber formation in vitro and in neointima after vessel injury.
Circulation research 2006;98(3):370-7.
2006: Thomas S Wilkinson; Steven L Bressler; Steven P Evanko; Kathleen R Braun; Thomas N Wight
Overexpression of hyaluronan synthases alters vascular smooth muscle cell phenotype and promotes monocyte adhesion.
Journal of cellular physiology 2006;206(2):378-85.
2005: Robert B Vernon; Michel D Gooden; Stephanie L Lara; Thomas N Wight
Microgrooved fibrillar collagen membranes as scaffolds for cell support and alignment.
Biomaterials 2005;26(16):3131-40.
2005: Pauli Puolakkainen; Amy D Bradshaw; Rolf Brekken; May J Reed; Themis Kyriakides; Sarah E Funk; Michel D Gooden; Robert B Vernon; Thomas N Wight; Paul Bornstein; E Helene Sage
SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(5):571-81.
2005: Kevin D O'Brien; Thomas O McDonald; Vidya V Kunjathoor; KimLi Eng; Eleanor A Knopp; Katherine Lewis; Roland Lopez; Elizabeth A Kirk; Alan Chait; Thomas N Wight; Frederick C deBeer; Renée C LeBoeuf
Serum amyloid A and lipoprotein retention in murine models of atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(4):785-90.
2005: Robert B Vernon; Michel D Gooden; Stephanie L Lara; Thomas N Wight
Native fibrillar collagen membranes of micron-scale and submicron thicknesses for cell support and perfusion.
Biomaterials 2005;26(10):1109-17.
2005: Richard D Kenagy; Jens W Fischer; Stephanie L Lara; John D Sandy; Alexander W Clowes; Thomas N Wight
Accumulation and loss of extracellular matrix during shear stress-mediated intimal growth and regression in baboon vascular grafts.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(1):131-40.
2004: Julie Nigro; Mandy L Ballinger; Rodney J Dilley; Garry L Jennings; Thomas N Wight; Peter Little
Fenofibrate modifies human vascular smooth muscle proteoglycans and reduces lipoprotein binding.
Diabetologia 2004;47(12):2105-13.
2004: Jens W Fischer; Susie A Steitz; Pamela Y Johnson; Allen P Burke; Frank D Kolodgie; Renu Virmani; Cecilia M Giachelli; Thomas N Wight
Decorin promotes aortic smooth muscle cell calcification and colocalizes to calcified regions in human atherosclerotic lesions.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(12):2391-6.
2004: Kevin D O'Brien; Katherine Lewis; Jens W Fischer; Pamela Johnson; Jin-Yong Hwang; Eleanor A Knopp; Michael G Kinsella; Hugh Barrett; Alan Chait; Thomas N Wight
Smooth muscle cell biglycan overexpression results in increased lipoprotein retention on extracellular matrix: implications for the retention of lipoproteins in atherosclerosis.
Atherosclerosis 2004;177(1):29-35.
2004: Katherine E Lewis; Elizabeth A Kirk; Thomas O McDonald; Shari Wang; Thomas N Wight; Kevin D O'Brien; Alan Chait
Increase in serum amyloid a evoked by dietary cholesterol is associated with increased atherosclerosis in mice.
Circulation 2004;110(5):540-5.
2004: Michael G Kinsella; Colleen Irvin; Michael A Reidy; Thomas N Wight
Removal of heparan sulfate by heparinase treatment inhibits FGF-2-dependent smooth muscle cell proliferation in injured rat carotid arteries.
Atherosclerosis 2004;175(1):51-7.
2004: K Jane Grande-Allen; Anthony Calabro; Vishal Gupta; Thomas N Wight; Vincent C Hascall; Ivan Vesely
Glycosaminoglycans and proteoglycans in normal mitral valve leaflets and chordae: association with regions of tensile and compressive loading.
Glycobiology 2004;14(7):621-33.
2004: Thomas S Wilkinson; Susan Potter-Perigo; Christina Tsoi; Leonard C Altman; Thomas N Wight
Pro- and anti-inflammatory factors cooperate to control hyaluronan synthesis in lung fibroblasts.
American journal of respiratory cell and molecular biology 2004;31(1):92-9.
2004: Thomas N Wight; Mervyn J Merrilees
Proteoglycans in atherosclerosis and restenosis: key roles for versican.
Circulation research 2004;94(9):1158-67.
2004: Lisa R Tannock; Peter Little; Christina Tsoi; Hugh Barrett; Thomas N Wight; Alan Chait
Thiazolidinediones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans.
Diabetologia 2004;47(5):837-43.
2004: Michael G Kinsella; Steven L Bressler; Thomas N Wight
The regulated synthesis of versican, decorin, and biglycan: extracellular matrix proteoglycans that influence cellular phenotype.
Critical reviews in eukaryotic gene expression 2004;14(3):203-34.
2004: Aleksander Hinek; Kathleen R Braun; Kela Liu; Yanting Wang; Thomas N Wight
Retrovirally mediated overexpression of versican v3 reverses impaired elastogenesis and heightened proliferation exhibited by fibroblasts from Costello syndrome and Hurler disease patients.
The American journal of pathology 2004;164(1):119-31.
2004: Hannu Järveläinen; Robert B Vernon; Michel D Gooden; Aleksandar Francki; Stephanie L Lara; Pamela Y Johnson; Michael G Kinsella; E Helene Sage; Thomas N Wight
Overexpression of decorin by rat arterial smooth muscle cells enhances contraction of type I collagen in vitro.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(1):67-72.
2004: Susan Potter-Perigo; Coralie Baker; Christina Tsoi; Kathleen R Braun; Scott Isenhath; Gaylene M Altman; Leonard C Altman; Thomas N Wight
Regulation of proteoglycan synthesis by leukotriene d4 and epidermal growth factor in bronchial smooth muscle cells.
American journal of respiratory cell and molecular biology 2004;30(1):101-8.
2003: C Daniel Meyers; Lisa R Tannock; Thomas N Wight; Alan Chait
Statin-exposed vascular smooth muscle cells secrete proteoglycans with decreased binding affinity for LDL.
Journal of lipid research 2003;44(11):2152-60.
2003: Kevin D O'Brien; Simona Vuletic; Thomas O McDonald; Gertrud Wolfbauer; Katherine Lewis; An-Yue Tu; Santica Marcovina; Thomas N Wight; Alan Chait; John J Albers
Cell-associated and extracellular phospholipid transfer protein in human coronary atherosclerosis.
Circulation 2003;108(3):270-4.
2003: Amy D Bradshaw; Pauli Puolakkainen; Jayasri Dasgupta; Jeffrey M Davidson; Thomas N Wight; E Helene Sage
SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strength.
The Journal of investigative dermatology 2003;120(6):949-55.
2003: Susan Potter-Perigo; Rebecca L Hull; Christina Tsoi; Kathleen R Braun; Sofianos Andrikopoulos; Jeanette C Teague; C Bruce Verchere; Steven E Kahn; Thomas N Wight
Proteoglycans synthesized and secreted by pancreatic islet beta-cells bind amylin.
Archives of biochemistry and biophysics 2003;413(2):182-90.
2003: Mary Y Chang; Christina Tsoi; Thomas N Wight; Alan Chait
Lysophosphatidylcholine regulates synthesis of biglycan and the proteoglycan form of macrophage colony stimulating factor.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(5):809-15.
2003: Charles W Frevert; Michael G Kinsella; Charie Vathanaprida; Richard B Goodman; Denis Baskin; Amanda Proudfoot; Timothy Wells; Thomas N Wight; Thomas R Martin
Binding of interleukin-8 to heparan sulfate and chondroitin sulfate in lung tissue.
American journal of respiratory cell and molecular biology 2003;28(4):464-72.
2003: Michael G Kinsella; Phan-Kiet Tran; Mary C M Weiser-Evans; Michael A Reidy; Richard A Majack; Thomas N Wight
Changes in perlecan expression during vascular injury: role in the inhibition of smooth muscle cell proliferation in the late lesion.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(4):608-14.
2003: Pauli Puolakkainen; Amy D Bradshaw; Themistoklis R Kyriakides; May Reed; Rolf Brekken; Thomas N Wight; Paul Bornstein; Buddy Ratner; E Helene Sage
Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials.
The American journal of pathology 2003;162(2):627-35.
2002: Ick-Mo Chung; Herman K Gold; Stephen M Schwartz; Yuji Ikari; Michael A Reidy; Thomas N Wight
Enhanced extracellular matrix accumulation in restenosis of coronary arteries after stent deployment.
Journal of the American College of Cardiology 2002;40(12):2072-81.
2002: Katherine Olin-Lewis; Ronald M Krauss; Michael La Belle; Patricia J Blanche; Hugh Barrett; Thomas N Wight; Alan Chait
ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycan.
Journal of lipid research 2002;43(11):1969-77.
2002: Thomas N Wight
Versican: a versatile extracellular matrix proteoglycan in cell biology.
Current opinion in cell biology 2002;14(5):617-23.
2002: Qi Yan; John I Clark; Thomas N Wight; E Helene Sage
Alterations in the lens capsule contribute to cataractogenesis in SPARC-null mice.
Journal of cell science 2002;115(Pt 13):2747-56.
2002: Katherine Olin-Lewis; Jeana L Benton; John C Rutledge; Denis Baskin; Thomas N Wight; Alan Chait
Apolipoprotein E mediates the retention of high-density lipoproteins by mouse carotid arteries and cultured arterial smooth muscle cell extracellular matrices.
Circulation research 2002;90(12):1333-9.
2002: Mervyn J Merrilees; Joan M Lemire; Jens W Fischer; Michael G Kinsella; Kathleen R Braun; Alexander W Clowes; Thomas N Wight
Retrovirally mediated overexpression of versican v3 by arterial smooth muscle cells induces tropoelastin synthesis and elastic fiber formation in vitro and in neointima after vascular injury.
Circulation research 2002;90(4):481-7.
2002: Richard D Kenagy; Jens W Fischer; Mark G Davies; Scott A Berceli; Suzanne M Hawkins; Thomas N Wight; Alexander W Clowes
Increased plasmin and serine proteinase activity during flow-induced intimal atrophy in baboon PTFE grafts.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(3):400-4.
2002: Bryan P Toole; Thomas N Wight; Markku Tammi
Hyaluronan-cell interactions in cancer and vascular disease.
The Journal of biological chemistry 2002;277(7):4593-6.
2002: Joan M Lemire; Mervyn J Merrilees; Kathleen R Braun; Thomas N Wight
Overexpression of the V3 variant of versican alters arterial smooth muscle cell adhesion, migration, and proliferation in vitro.
Journal of cellular physiology 2002;190(1):38-45.
2002: Lisa R Tannock; Peter Little; Thomas N Wight; Alan Chait
Arterial smooth muscle cell proteoglycans synthesized in the presence of glucosamine demonstrate reduced binding to LDL.
Journal of lipid research 2002;43(1):149-57.
2002: Lisa R Tannock; Katherine L Olin; Hugh Barrett; Thomas N Wight; Alan Chait
Triglyceride-rich lipoproteins from subjects with type 2 diabetes do not demonstrate increased binding to biglycan, a vascular proteoglycan.
The Journal of clinical endocrinology and metabolism 2002;87(1):35-40.
2002: Peter Little; Lisa R Tannock; Katherine L Olin; Alan Chait; Thomas N Wight
Proteoglycans synthesized by arterial smooth muscle cells in the presence of transforming growth factor-beta1 exhibit increased binding to LDLs.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(1):55-60.
2001: Steven P Evanko; Pamela Y Johnson; Kathleen R Braun; C B Underhill; J Dudhia; Thomas N Wight
Platelet-derived growth factor stimulates the formation of versican-hyaluronan aggregates and pericellular matrix expansion in arterial smooth muscle cells.
Archives of biochemistry and biophysics 2001;394(1):29-38.
2001: Karin Lundmark; Phan-Kiet Tran; Michael G Kinsella; Alexander W Clowes; Thomas N Wight; Ulf Hedin
Perlecan inhibits smooth muscle cell adhesion to fibronectin: role of heparan sulfate.
Journal of cellular physiology 2001;188(1):67-74.
2001: Mary Y Chang; Susan Potter-Perigo; Thomas N Wight; Alan Chait
Oxidized LDL bind to nonproteoglycan components of smooth muscle extracellular matrices.
Journal of lipid research 2001;42(5):824-33.
2001: Jens W Fischer; Michael G Kinsella; Bodo Levkau; Alexander W Clowes; Thomas N Wight
Retroviral overexpression of decorin differentially affects the response of arterial smooth muscle cells to growth factors.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(5):777-84.
2001: Richard T Lee; C Yamamoto; Y Feng; Susan Potter-Perigo; W H Briggs; Katherine Landschulz; Thomas G Turi; John F Thompson; Peter Libby; Thomas N Wight
Mechanical strain induces specific changes in the synthesis and organization of proteoglycans by vascular smooth muscle cells.
The Journal of biological chemistry 2001;276(17):13847-51.
2001: John D Sandy; Jennifer Westling; Richard D Kenagy; M Luisa Iruela-Arispe; C Verscharen; J C Rodriguez-Mazaneque; D R Zimmermann; Joan M Lemire; Jens W Fischer; Thomas N Wight; Alexander W Clowes
Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4.
The Journal of biological chemistry 2001;276(16):13372-8.
2001: Stephanie L Lara; SP Evanko; Thomas N Wight
Morphological evaluation of proteoglycans in cells and tissues.
Methods in molecular biology (Clifton, N.J.) 2001;171():271-90.
2001: Jens W Fischer; Michael G Kinsella; D Hasenstab; Alexander W Clowes; Thomas N Wight
Cell-mediated transfer of proteoglycan genes.
Methods in molecular biology (Clifton, N.J.) 2001;171():261-9.
2001: Katherine L Olin; Susan Potter-Perigo; Hugh Barrett; Thomas N Wight; Alan Chait
Biglycan, a vascular proteoglycan, binds differently to HDL2 and HDL3: role of apoE.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(1):129-35.
2000: E Kaneko; M P Skinner; Elaine W Raines; Chun Yuan; Michael E Rosenfeld; Thomas N Wight; R Ross
Detection of dissection and remodeling of atherosclerotic lesions in rabbits after balloon angioplasty by magnetic-resonance imaging.
Coronary artery disease 2000;11(8):599-606.
2000: Alan Chait; Thomas N Wight
Interaction of native and modified low-density lipoproteins with extracellular matrix.
Current opinion in lipidology 2000;11(5):457-63.
2000: Michael G Kinsella; Jens W Fischer; D P Mason; Thomas N Wight
Retrovirally mediated expression of decorin by macrovascular endothelial cells. Effects on cellular migration and fibronectin fibrillogenesis in vitro.
The Journal of biological chemistry 2000;275(18):13924-32.
2000: Jens W Fischer; Michael G Kinsella; MM Clowes; Stephanie L Lara; Alexander W Clowes; Thomas N Wight
Local expression of bovine decorin by cell-mediated gene transfer reduces neointimal formation after balloon injury in rats.
Circulation research 2000;86(6):676-83.
2000: Mary Y Chang; Susan Potter-Perigo; Christina Tsoi; Alan Chait; Thomas N Wight
Oxidized low density lipoproteins regulate synthesis of monkey aortic smooth muscle cell proteoglycans that have enhanced native low density lipoprotein binding properties.
The Journal of biological chemistry 2000;275(7):4766-73.
1999: Katherine L Olin; Susan Potter-Perigo; Hugh Barrett; Thomas N Wight; Alan Chait
Lipoprotein lipase enhances the binding of native and oxidized low density lipoproteins to versican and biglycan synthesized by cultured arterial smooth muscle cells.
The Journal of biological chemistry 1999;274(49):34629-36.
1999: Sofianos Andrikopoulos; C Bruce Verchere; Jeanette C Teague; W M Howell; Wilfred Y Fujimoto; Thomas N Wight; Steven E Kahn
Two novel immortal pancreatic beta-cell lines expressing and secreting human islet amyloid polypeptide do not spontaneously develop islet amyloid.
Diabetes 1999;48(10):1962-70.
1999: SP Evanko; Thomas N Wight
Intracellular localization of hyaluronan in proliferating cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999;47(10):1331-42.
1999: Joan M Lemire; Kathleen R Braun; P Maurel; E D Kaplan; Stephen M Schwartz; Thomas N Wight
Versican/PG-M isoforms in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(7):1630-9.
1999: SP Evanko; John C Angello; Thomas N Wight
Formation of hyaluronan- and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(4):1004-13.
1999: GM Castillo; W Lukito; Thomas N Wight; AD Snow
The sulfate moieties of glycosaminoglycans are critical for the enhancement of beta-amyloid protein fibril formation.
Journal of neurochemistry 1999;72(4):1681-7.
1998: AJ Jabbour; Leonard C Altman; Thomas N Wight; Daniel L Luchtel
Ozone alters the distribution of beta1 integrins in cultured primate bronchial epithelial cells.
American journal of respiratory cell and molecular biology 1998;19(3):357-65.
1998: Kevin D O'Brien; Katherine L Olin; C E Alpers; W Chiu; M Ferguson; Kelly Hudkins; Thomas N Wight; Alan Chait
Comparison of apolipoprotein and proteoglycan deposits in human coronary atherosclerotic plaques: colocalization of biglycan with apolipoproteins.
Circulation 1998;98(6):519-27.
1998: N Koyama; Michael G Kinsella; Thomas N Wight; Ulf Hedin; Alexander W Clowes
Heparan sulfate proteoglycans mediate a potent inhibitory signal for migration of vascular smooth muscle cells.
Circulation research 1998;83(3):305-13.
1998: Mary Y Chang; Katherine L Olin; Christina Tsoi; Thomas N Wight; Alan Chait
Human monocyte-derived macrophages secrete two forms of proteoglycan-macrophage colony-stimulating factor that differ in their ability to bind low density lipoproteins.
The Journal of biological chemistry 1998;273(26):15985-92.
1998: Susan Potter-Perigo; E D Kaplan; Daniel L Luchtel; Coralie Baker; Leonard C Altman; Thomas N Wight
Ozone alters the expression of tenascin-C in cultured primate nasal epithelial cells.
American journal of respiratory cell and molecular biology 1998;18(4):471-8.
1998: SP Evanko; Elaine W Raines; Russell Ross; L I Gold; Thomas N Wight
Proteoglycan distribution in lesions of atherosclerosis depends on lesion severity, structural characteristics, and the proximity of platelet-derived growth factor and transforming growth factor-beta.
The American journal of pathology 1998;152(2):533-46.
1997: GM Castillo; Christina T Ngo; Jeffrey L Cummings; Thomas N Wight; AD Snow
Perlecan binds to the beta-amyloid proteins (A beta) of Alzheimer's disease, accelerates A beta fibril formation, and maintains A beta fibril stability.
Journal of neurochemistry 1997;69(6):2452-65.
1997: J D Miller; J Cummings; G A Maresh; Douglas G. Walker; GM Castillo; Christina T Ngo; K Kimata; Michael G Kinsella; Thomas N Wight; AD Snow
Localization of perlecan (or a perlecan-related macromolecule) to isolated microglia in vitro and to microglia/macrophages following infusion of beta-amyloid protein into rodent hippocampus.
Glia 1997;21(2):228-43.
1997: Thomas N Wight; Stephanie L Lara; R Riessen; Richard G LeBaron; J Isner
Selective deposits of versican in the extracellular matrix of restenotic lesions from human peripheral arteries.
The American journal of pathology 1997;151(4):963-73.
1997: E Schönherr; Michael G Kinsella; Thomas N Wight
Genistein selectively inhibits platelet-derived growth factor-stimulated versican biosynthesis in monkey arterial smooth muscle cells.
Archives of biochemistry and biophysics 1997;339(2):353-61.
1997: Michael G Kinsella; Christina Tsoi; Hannu Järveläinen; Thomas N Wight
Selective expression and processing of biglycan during migration of bovine aortic endothelial cells. The role of endogenous basic fibroblast growth factor.
The Journal of biological chemistry 1997;272(1):318-25.
1996: Susan Potter-Perigo; Thomas N Wight
Heparin causes the accumulation of heparan sulfate in cultures of arterial smooth muscle cells.
Archives of biochemistry and biophysics 1996;336(1):19-26.
1996: I Halpert; U I Sires; J D Roby; Susan Potter-Perigo; Thomas N Wight; S D Shapiro; Howard G Welgus; Samuel A Wickline; W C Parks
Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9748-53.
1996: S S Carlson; M Iwata; Thomas N Wight
A chondroitin sulfate/keratan sulfate proteoglycan, PG-1000, forms complexes which are concentrated in the reticular laminae of electric organ basement membranes.
Matrix biology : journal of the International Society for Matrix Biology 1996;15(4):281-92.
1996: Joan M Lemire; Susan Potter-Perigo; K L Hall; Thomas N Wight; Stephen M Schwartz
Distinct rat aortic smooth muscle cells differ in versican/PG-M expression.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(6):821-9.
1995: AD Snow; Michael G Kinsella; E Parks; R T Sekiguchi; J D Miller; K Kimata; Thomas N Wight
Differential binding of vascular cell-derived proteoglycans (perlecan, biglycan, decorin, and versican) to the beta-amyloid protein of Alzheimer's disease.
Archives of biochemistry and biophysics 1995;320(1):84-95.
1995: C O Ostberg; P Zhu; Thomas N Wight; Eva E Qwarnstrom
Fibronectin attachment is permissive for IL-1 mediated gene regulation.
FEBS letters 1995;367(1):93-7.
1995: Robert B Vernon; S L Lara; Christopher J Drake; M Luisa Iruela-Arispe; John C Angello; Charles D Little; Thomas N Wight; E Helene Sage
Organized type I collagen influences endothelial patterns during "spontaneous angiogenesis in vitro": planar cultures as models of vascular development.
In vitro cellular & developmental biology. Animal 1995;31(2):120-31.
1994: R T Sekiguchi; Susan Potter-Perigo; K Braun; J Miller; C Ngo; Ken-Ichiro Fukuchi; Thomas N Wight; K Kimata; AD Snow
Characterization of proteoglycans synthesized by murine embryonal carcinoma cells (P19) reveals increased expression of perlecan (heparan sulfate proteoglycan) during neuronal differentiation.
Journal of neuroscience research 1994;38(6):670-86.
1994: S T Nikkari; Hannu Järveläinen; Thomas N Wight; M Ferguson; Alexander W Clowes
Smooth muscle cell expression of extracellular matrix genes after arterial injury.
The American journal of pathology 1994;144(6):1348-56.
1994: L Y Yao; C Moody; E Schönherr; Thomas N Wight; Linda J Sandell
Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry.
Matrix biology : journal of the International Society for Matrix Biology 1994;14(3):213-25.
1993: Seymour J Klebanoff; Michael G Kinsella; Thomas N Wight
Degradation of endothelial cell matrix heparan sulfate proteoglycan by elastase and the myeloperoxidase-H2O2-chloride system.
The American journal of pathology 1993;143(3):907-17.
1993: E E Qwarnström; Hannu Järveläinen; Michael G Kinsella; C O Ostberg; Linda J Sandell; Roy C Page; Thomas N Wight
Interleukin-1 beta regulation of fibroblast proteoglycan synthesis involves a decrease in versican steady-state mRNA levels.
The Biochemical journal 1993;294 ( Pt 2)():613-20.
1993: M Iwata; Thomas N Wight; S S Carlson
A brain extracellular matrix proteoglycan forms aggregates with hyaluronan.
The Journal of biological chemistry 1993;268(20):15061-9.
1993: E Schönherr; Hannu Järveläinen; Michael G Kinsella; Linda J Sandell; Thomas N Wight
Platelet-derived growth factor and transforming growth factor-beta 1 differentially affect the synthesis of biglycan and decorin by monkey arterial smooth muscle cells.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(7):1026-36.
1993: Susan Potter-Perigo; P Prather; C Baker; Leonard C Altman; Thomas N Wight
Partial characterization of proteoglycans synthesized by human gingival epithelial cells in culture.
Journal of periodontal research 1993;28(2):81-91.
1993: S E Juul; Michael G Kinsella; Thomas N Wight; W A Hodson
Alterations in nonhuman primate (M. nemestrina) lung proteoglycans during normal development and acute hyaline membrane disease.
American journal of respiratory cell and molecular biology 1993;8(3):299-310.
1992: Hannu Järveläinen; M Luisa Iruela-Arispe; Michael G Kinsella; Linda J Sandell; E Helene Sage; Thomas N Wight
Expression of decorin by sprouting bovine aortic endothelial cells exhibiting angiogenesis in vitro.
Experimental cell research 1992;203(2):395-401.
1992: Thomas N Wight; Michael G Kinsella; E E Qwarnström
The role of proteoglycans in cell adhesion, migration and proliferation.
Current opinion in cell biology 1992;4(5):793-801.
1992: Susan Potter-Perigo; K R Braun; E Schönherr; Thomas N Wight
Altered proteoglycan synthesis via the false acceptor pathway can be dissociated from beta-D-xyloside inhibition of proliferation.
Archives of biochemistry and biophysics 1992;297(1):101-9.
1992: Ken-Ichiro Fukuchi; Samir S Deeb; K Kamino; Charles E Ogburn; AD Snow; R T Sekiguchi; Thomas N Wight; H Piussan; George M Martin
Increased expression of beta-amyloid protein precursor and microtubule-associated protein tau during the differentiation of murine embryonal carcinoma cells.
Journal of neurochemistry 1992;58(5):1863-73.
1992: T K Yeo; K T Yeo; Thomas N Wight
Differential transport kinetics of chondroitin sulfate and dermatan sulfate proteoglycan by monkey aorta smooth muscle cells.
Archives of biochemistry and biophysics 1992;294(1):9-16.
1992: E E Qwarnström; Michael G Kinsella; S A MacFarlane; Roy C Page; Thomas N Wight
Modulation of proteoglycan metabolism by human fibroblasts maintained in an endogenous three-dimensional matrix.
European journal of cell biology 1992;57(1):101-8.
1992: T K Yeo; S Macfarlane; Thomas N Wight
Characterization of a chondroitin sulfate proteoglycan synthesized by monkey arterial smooth muscle cells in vitro.
Connective tissue research 1992;27(4):265-77.
1992: AD Snow; H Mar; David Nochlin; H Kresse; Thomas N Wight
Peripheral distribution of dermatan sulfate proteoglycans (decorin) in amyloid-containing plaques and their presence in neurofibrillary tangles of Alzheimer's disease.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1992;40(1):105-13.
1991: Hannu Järveläinen; Michael G Kinsella; Thomas N Wight; Linda J Sandell
Differential expression of small chondroitin/dermatan sulfate proteoglycans, PG-I/biglycan and PG-II/decorin, by vascular smooth muscle and endothelial cells in culture.
The Journal of biological chemistry 1991;266(34):23274-81.
1991: AD Snow; R Bramson; H Mar; Thomas N Wight; Robert Kisilevsky
A temporal and ultrastructural relationship between heparan sulfate proteoglycans and AA amyloid in experimental amyloidosis.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1991;39(10):1321-30.
1991: E Schönherr; Hannu Järveläinen; Linda J Sandell; Thomas N Wight
Effects of platelet-derived growth factor and transforming growth factor-beta 1 on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells.
The Journal of biological chemistry 1991;266(26):17640-7.
1990: AD Snow; H Mar; David Nochlin; R T Sekiguchi; K Kimata; Y Koike; Thomas N Wight
Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome.
The American journal of pathology 1990;137(5):1253-70.
1990: AD Snow; Thomas N Wight; David Nochlin; Y Koike; K Kimata; S J DeArmond; Stanley B Prusiner
Immunolocalization of heparan sulfate proteoglycans to the prion protein amyloid plaques of Gerstmann-Straussler syndrome, Creutzfeldt-Jakob disease and scrapie.
Laboratory investigation; a journal of technical methods and pathology 1990;63(5):601-11.
1990: Michael G Kinsella; Thomas N Wight
Formation of high molecular weight dermatan sulfate proteoglycan in bovine aortic endothelial cell cultures. Evidence for transglutaminase-catalyzed cross-linking to fibronectin.
The Journal of biological chemistry 1990;265(29):17891-8.
1990: AD Snow; R P Bolender; Thomas N Wight; Alexander W Clowes
Heparin modulates the composition of the extracellular matrix domain surrounding arterial smooth muscle cells.
The American journal of pathology 1990;137(2):313-30.
1989: Thomas N Wight; Susan Potter-Perigo; T Aulinskas
Proteoglycans and vascular cell proliferation.
The American review of respiratory disease 1989;140(4):1132-5.
1989: AD Snow; Thomas N Wight
Proteoglycans in the pathogenesis of Alzheimer's disease and other amyloidoses.
Neurobiology of aging 1989;10(5):481-97.
1989: AD Snow; H Mar; David Nochlin; Thomas N Wight
Congo red staining on 1 micron de-plasticized sections for detection of lesions in Alzheimer's disease and related disorders.
Progress in clinical and biological research 1989;317():383-91.
1989: AD Snow; S Lara; David Nochlin; Thomas N Wight
Cationic dyes reveal proteoglycans structurally integrated within the characteristic lesions of Alzheimer's disease.
Acta neuropathologica 1989;78(2):113-23.
1988: Michael G Kinsella; Thomas N Wight
Isolation and characterization of dermatan sulfate proteoglycans synthesized by cultured bovine aortic endothelial cells.
The Journal of biological chemistry 1988;263(35):19222-31.
1988: AD Snow; H Mar; David Nochlin; K Kimata; M Kato; S Suzuki; J Hassell; Thomas N Wight
The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.
The American journal of pathology 1988;133(3):456-63.
1988: H Mar; Thomas N Wight
Colloidal gold immunostaining on deplasticized ultra-thin sections.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1988;36(11):1387-95.
1988: M W Lark; T K Yeo; H Mar; S Lara; Ingegerd Hellström; Karl Erik Hellström; Thomas N Wight
Arterial chondroitin sulfate proteoglycan: localization with a monoclonal antibody.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1988;36(10):1211-21.
1988: Michael G Kinsella; Thomas N Wight
Structural characterization of heparan sulfate proteoglycan subclasses isolated from bovine aortic endothelial cell cultures.
Biochemistry 1988;27(6):2136-44.
1987: S S Carlson; Thomas N Wight
Nerve terminal anchorage protein 1 (TAP-1) is a chondroitin sulfate proteoglycan: biochemical and electron microscopic characterization.
The Journal of cell biology 1987;105(6 Pt 2):3075-86.
1987: H Mar; T Tsukada; A M Gown; Thomas N Wight; Denis Baskin
Correlative light and electron microscopic immunocytochemistry on the same section with colloidal gold.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1987;35(4):419-25.
1986: H J Garrigues; M W Lark; S Lara; Ingegerd Hellström; Karl Erik Hellström; Thomas N Wight
The melanoma proteoglycan: restricted expression on microspikes, a specific microdomain of the cell surface.
The Journal of cell biology 1986;103(5):1699-710.