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Michael Wigler

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Bric Anka; Miething Cornelius; Bialucha Carl Uli; Scuoppo Claudio; Zender Lars; Krasnitz Alexander; Xuan Zhenyu; Zuber Johannes; Wigler Michael; Hicks James; McCombie Richard W; Hemann Michael T; Hannon Gregory J; Powers Scott; Lowe Scott W
Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.
Hodges Emily; Smith Andrew D; Kendall Jude; Xuan Zhenyu; Ravi Kandasamy; Rooks Michelle; Zhang Michael Q; Ye Kenny; Bhattacharjee Arindam; Brizuela Leonardo; McCombie W Richard; Wigler Michael; Hannon Gregory J; Hicks James B
High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing.
Grubor Vladimir; Krasnitz Alex; Troge Jennifer E; Meth Jennifer L; Lakshmi B; Kendall Jude T; Yamrom Boris; Alex Garrick; Pai Deepa; Navin Nicholas; Hufnagel Lisa A; Lee Yoon-Ha; Cook Kerry; Allen Steven L; Rai Kanti R; Damle Rajendra N; Calissano Carlo; Chiorazzi Nicholas; Wigler Michael; Esposito Diane
Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA).

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All Publications

2009: Bric Anka; Miething Cornelius; Bialucha Carl Uli; Scuoppo Claudio; Zender Lars; Krasnitz Alexander; Xuan Zhenyu; Zuber Johannes; Wigler Michael; Hicks James; McCombie Richard W; Hemann Michael T; Hannon Gregory J; Powers Scott; Lowe Scott W
Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.
Cancer cell 2009;16(4):324-35.
2009: Hodges Emily; Smith Andrew D; Kendall Jude; Xuan Zhenyu; Ravi Kandasamy; Rooks Michelle; Zhang Michael Q; Ye Kenny; Bhattacharjee Arindam; Brizuela Leonardo; McCombie W Richard; Wigler Michael; Hannon Gregory J; Hicks James B
High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing.
Genome research 2009;19(9):1593-605.
2009: Grubor Vladimir; Krasnitz Alex; Troge Jennifer E; Meth Jennifer L; Lakshmi B; Kendall Jude T; Yamrom Boris; Alex Garrick; Pai Deepa; Navin Nicholas; Hufnagel Lisa A; Lee Yoon-Ha; Cook Kerry; Allen Steven L; Rai Kanti R; Damle Rajendra N; Calissano Carlo; Chiorazzi Nicholas; Wigler Michael; Esposito Diane
Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA).
Blood 2009;113(6):1294-303.
2008: Zender Lars; Xue Wen; Zuber Johannes; Semighini Camile P; Krasnitz Alexander; Ma Beicong; Zender Peggy; Kubicka Stefan; Luk John M; Schirmacher Peter; McCombie W Richard; Wigler Michael; Hicks James; Hannon Gregory J; Powers Scott; Lowe Scott W
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer.
Cell 2008;135(5):852-64.
2008: Xue Wen; Krasnitz Alexander; Lucito Robert; Sordella Raffaella; Vanaelst Linda; Cordon-Cardo Carlos; Singer Stephan; Kuehnel Florian; Wigler Michael; Powers Scott; Zender Lars; Lowe Scott W
DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma.
Genes & development 2008;22(11):1439-44.
2008: Alarcón Maricela; Abrahams Brett S; Stone Jennifer L; Duvall Jacqueline A; Perederiy Julia V; Bomar Jamee M; Sebat Jonathan; Wigler Michael; Martin Christa L; Ledbetter David H; Nelson Stanley F; Cantor Rita M; Geschwind Daniel H
Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene.
American journal of human genetics 2008;82(1):150-9.
2007: Egan Chris M; Sridhar Srinath; Wigler Michael; Hall Ira M
Recurrent DNA copy number variation in the laboratory mouse.
Nature genetics 2007;39(11):1384-9.
2007: Lucito Robert; Suresh Shubha; Walter Kimberly; Pandey Akhilesh; Lakshmi B; Krasnitz Alex; Sebat Jonathan; Wigler Michael; Klein Alison P; Brune Kieran; Palmisano Emily; Maitra Anirban; Goggins Michael; Hruban Ralph H
Copy-number variants in patients with a strong family history of pancreatic cancer.
Cancer biology & therapy 2007;6(10):1592-9.
2007: Zhao Xiaoyue; Leotta Anthony; Kustanovich Vlad; Lajonchere Clara; Geschwind Daniel H; Law Kiely; Law Paul; Qiu Shanping; Lord Catherine; Sebat Jonathan; Ye Kenny; Wigler Michael
A unified genetic theory for sporadic and inherited autism.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12831-6.
2007: Sebat Jonathan; Lakshmi B; Malhotra Dheeraj; Troge Jennifer; Lese-Martin Christa; Walsh Tom; Yamrom Boris; Yoon Seungtai; Krasnitz Alex; Kendall Jude; Leotta Anthony; Pai Deepa; Zhang Ray; Lee Yoon-Ha; Hicks James; Spence Sarah J; Lee Annette T; Puura Kaija; Lehtimäki Terho; Ledbetter David; Gregersen Peter K; Bregman Joel; Sutcliffe James S; Jobanputra Vaidehi; Chung Wendy; Warburton Dorothy; King Mary-Claire; Skuse David; Geschwind Daniel H; Gilliam T Conrad; Ye Kenny; Wigler Michael
Strong association of de novo copy number mutations with autism.
Science (New York, N.Y.) 2007;316(5823):445-9.
2006: Pelham Robert J; Rodgers Linda; Hall Ira; Lucito Robert; Nguyen Ken C Q; Navin Nicholas; Hicks James; Mu David; Powers Scott; Wigler Michael; Botstein David
Identification of alterations in DNA copy number in host stromal cells during tumor progression.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(52):19848-53.
2006: Hicks James; Krasnitz Alexander; Lakshmi B; Navin Nicholas E; Riggs Michael; Leibu Evan; Esposito Diane; Alexander Joan; Troge Jen; Grubor Vladimir; Yoon Seungtai; Wigler Michael; Ye Kenny; Børresen-Dale Anne-Lise; Naume Bjørn; Schlicting Ellen; Norton Larry; Hägerström Torsten; Skoog Lambert; Auer Gert; Månér Susanne; Lundin Pär; Zetterberg Anders
Novel patterns of genome rearrangement and their association with survival in breast cancer.
Genome research 2006;16(12):1465-79.
2006: Navin Nicholas; Grubor Vladimir; Hicks Jim; Leibu Evan; Thomas Elizabeth; Troge Jennifer; Riggs Michael; Lundin Pär; Månér Susanne; Sebat Jonathan; Zetterberg Anders; Wigler Michael
PROBER: oligonucleotide FISH probe design software.
Bioinformatics (Oxford, England) 2006;22(19):2437-8.
2006: Lakshmi B; Hall Ira M; Egan Christopher; Alexander Joan; Leotta Anthony; Healy John; Zender Lars; Spector Mona S; Xue Wen; Lowe Scott W; Wigler Michael; Lucito Robert
Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11234-9.
2006: Zender Lars; Spector Mona S; Xue Wen; Flemming Peer; Cordon-Cardo Carlos; Silke John; Fan Sheung-Tat; Luk John M; Wigler Michael; Hannon Gregory J; Mu David; Lucito Robert; Powers Scott; Lowe Scott W
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach.
Cell 2006;125(7):1253-67.
2006: West Joseph; Healy John; Wigler Michael; Casey William; Mishra Bud
Validation of S. pombe sequence assembly by microarray hybridization.
Journal of computational biology : a journal of computational molecular cell biology 2006;13(1):1-20.
2005: Jobanputra Vaidehi; Sebat Jonathan; Troge Jennifer; Chung Wendy; Anyane-Yeboa Kwame; Wigler Michael; Warburton Dorothy
Application of ROMA (representational oligonucleotide microarray analysis) to patients with cytogenetic rearrangements.
Genetics in medicine : official journal of the American College of Medical Genetics 2005;7(2):111-8.
2005: Hicks J; Muthuswamy L; Krasnitz A; Navin N; Riggs M; Grubor V; Esposito D; Alexander J; Troge J; Wigler M; Maner S; Lundin P; Zetterberg A
High-resolution ROMA CGH and FISH analysis of aneuploid and diploid breast tumors.
Cold Spring Harbor symposia on quantitative biology 2005;70():51-63.
2004: Daruwala Raoul-Sam; Rudra Archisman; Ostrer Harry; Lucito Robert; Wigler Michael; Mishra Bud
A versatile statistical analysis algorithm to detect genome copy number variation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(46):16292-7.
2004: Olshen Adam B; Venkatraman E S; Lucito Robert; Wigler Michael
Circular binary segmentation for the analysis of array-based DNA copy number data.
Biostatistics (Oxford, England) 2004;5(4):557-72.
2004: Sebat Jonathan; Lakshmi B; Troge Jennifer; Alexander Joan; Young Janet; Lundin Pär; Månér Susanne; Massa Hillary; Walker Megan; Chi Maoyen; Navin Nicholas; Lucito Robert; Healy John; Hicks James; Ye Kenny; Reiner Andrew; Gilliam T Conrad; Trask Barbara; Patterson Nick; Zetterberg Anders; Wigler Michael
Large-scale copy number polymorphism in the human genome.
Science (New York, N.Y.) 2004;305(5683):525-8.
2004: Thomas Elizabeth E; Srebro Nathan; Sebat Jonathan; Navin Nicholas; Healy John; Mishra Bud; Wigler Michael
Distribution of short paired duplications in mammalian genomes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(28):10349-54.
2003: Healy John; Thomas Elizabeth E; Schwartz Jacob T; Wigler Michael
Annotating large genomes with exact word matches.
Genome research 2003;13(10):2306-15.
2003: Lucito Robert; Healy John; Alexander Joan; Reiner Andrew; Esposito Diane; Chi Maoyen; Rodgers Linda; Brady Amy; Sebat Jonathan; Troge Jennifer; West Joseph A; Rostan Seth; Nguyen Ken C Q; Powers Scott; Ye Kenneth Q; Olshen Adam; Venkatraman Ennapadam; Norton Larry; Wigler Michael
Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number variation.
Genome research 2003;13(10):2291-305.
2003: Mu David; Chen Liyun; Zhang Xiping; See Lei-Hoon; Koch Christina M; Yen Clifford; Tong James Jiayuan; Spiegel Lori; Nguyen Ken C Q; Servoss Allyson; Peng Yue; Pei Lin; Marks Jeffrey R; Lowe Scott; Hoey Timothy; Jan Lily Yeh; McCombie W Richard; Wigler Michael H; Powers Scott
Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.
Cancer cell 2003;3(3):297-302.
2003: Mishra Bud; Daruwala Raoul-Sam; Zhou Yi; Ugel Nadia; Policriti Alberto; Antoniotti Marco; Paxia Salvatore; Rejali Marc; Rudra Archisman; Cherepinsky Vera; Silver Naomi; Casey William; Piazza Carla; Simeoni Marta; Barbano Paolo; Spivak Marina; Feng Jiawu; Gill Ofer; Venkatesh Mysore; Cheng Fang; Sun Bing; Ioniata Iuliana; Anantharaman Thomas; Hubbard E Jane Albert; Pnueli Amir; Harel David; Chandru Vijay; Hariharan Ramesh; Wigler Michael; Park Frank; Lin Shih-Chieh; Lazebnik Yuri; Winkler Franz; Cantor Charles R; Carbone Alessandra; Gromov Mikhael
A sense of life: computational and experimental investigations with models of biochemical and evolutionary processes.
Omics : a journal of integrative biology 2003;7(3):253-68.
2002: Hamaguchi Masaaki; Meth Jennifer L; von Klitzing Christine; Wei Wen; Esposito Diane; Rodgers Linda; Walsh Tom; Welcsh Piri; King Mary-Claire; Wigler Michael H
DBC2, a candidate for a tumor suppressor gene involved in breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13647-52.
2002: Wigler Michael; Mishra Bud
Genetics. Wild by nature.
Science (New York, N.Y.) 2002;296(5572):1407-8.
2001: Scheffzek K; Grünewald P; Wohlgemuth S; Kabsch W; Tu H; Wigler M; Wittinghofer A; Herrmann C
The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast.
Structure (London, England : 1993) 2001;9(11):1043-50.
2001: Stolarov J; Chang K; Reiner A; Rodgers L; Hannon G J; Wigler M H; Mittal V
Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13043-8.
2001: Wen S; Stolarov J; Myers M P; Su J D; Wigler M H; Tonks N K; Durden D L
PTEN controls tumor-induced angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4622-7.
2000: Lucito R; West J; Reiner A; Alexander J; Esposito D; Mishra B; Powers S; Norton L; Wigler M
Detecting gene copy number fluctuations in tumor cells by microarray analysis of genomic representations.
Genome research 2000;10(11):1726-36.
1999: Dong D L; Liu R; Sherlock R; Wigler M H; Nestler H P
Molecular forceps from combinatorial libraries prevent the farnesylation of Ras by binding to its carboxyl terminus.
Chemistry & biology 1999;6(3):133-41.
1999: Tu H; Wigler M
Genetic evidence for Pak1 autoinhibition and its release by Cdc42.
Molecular and cellular biology 1999;19(1):602-11.
1998: Myers M P; Pass I; Batty I H; Van der Kaay J; Stolarov J P; Hemmings B A; Wigler M H; Downes C P; Tonks N K
The lipid phosphatase activity of PTEN is critical for its tumor supressor function.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13513-8.
1998: Webb C P; Van Aelst L; Wigler M H; Woude G F
Signaling pathways in Ras-mediated tumorigenicity and metastasis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8773-8.
1998: Lucito R; Nakimura M; West J A; Han Y; Chin K; Jensen K; McCombie R; Gray J W; Wigler M
Genetic analysis using genomic representations.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4487-92.
1998: Hamaguchi M; O'Connor E A; Chen T; Parnell L; McCombie R W; Wigler M H
Rapid isolation of cDNA by hybridization.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3764-9.
1997: Tu H; Barr M; Dong D L; Wigler M
Multiple regulatory domains on the Byr2 protein kinase.
Molecular and cellular biology 1997;17(10):5876-87.
1997: Myers M P; Stolarov J P; Eng C; Li J; Wang S I; Wigler M H; Parsons R; Tonks N K
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9052-7.
1997: Li J; Yen C; Liaw D; Podsypanina K; Bose S; Wang S I; Puc J; Miliaresis C; Rodgers L; McCombie R; Bigner S H; Giovanella B C; Ittmann M; Tycko B; Hibshoosh H; Wigler M H; Parsons R
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.
Science (New York, N.Y.) 1997;275(5308):1943-7.
1996: Barr M M; Tu H; Van Aelst L; Wigler M
Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.
Molecular and cellular biology 1996;16(10):5597-603.
1996: Thiagalingam S; Lisitsyn N A; Hamaguchi M; Wigler M H; Willson J K; Markowitz S D; Leach F S; Kinzler K W; Vogelstein B
Evaluation of the FHIT gene in colorectal cancers.
Cancer research 1996;56(13):2936-9.
1996: Khosravi-Far R; White M A; Westwick J K; Solski P A; Chrzanowska-Wodnicka M; Van Aelst L; Wigler M H; Der C J
Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation.
Molecular and cellular biology 1996;16(7):3923-33.
1996: White M A; Vale T; Camonis J H; Schaefer E; Wigler M H
A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation.
The Journal of biological chemistry 1996;271(28):16439-42.
1996: Joneson T; White M A; Wigler M H; Bar-Sagi D
Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.
Science (New York, N.Y.) 1996;271(5250):810-2.
1996: Xu H P; Yanak B L; Wigler M H; Gorin M B
New polymorphic markers in the vicinity of the pearl locus on mouse chromosome 13.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(1):16-9.
1995: Marcus S; Polverino A; Chang E; Robbins D; Cobb M H; Wigler M H
Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):6180-4.
1995: Jung V; Chen L; Hofmann S L; Wigler M; Powers S
Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins.
Molecular and cellular biology 1995;15(3):1333-42.
1995: White M A; Nicolette C; Minden A; Polverino A; Van Aelst L; Karin M; Wigler M H
Multiple Ras functions can contribute to mammalian cell transformation.
Cell 1995;80(4):533-41.
1995: Lisitsyn N A; Lisitsina N M; Dalbagni G; Barker P; Sanchez C A; Gnarra J; Linehan W M; Reid B J; Wigler M H
Comparative genomic analysis of tumors: detection of DNA losses and amplification.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(1):151-5.
1995: Lisitsyn N; Wigler M
Representational difference analysis in detection of genetic lesions in cancer.
Methods in enzymology 1995;254():291-304.
1994: Chang E C; Barr M; Wang Y; Jung V; Xu H P; Wigler M H
Cooperative interaction of S. pombe proteins required for mating and morphogenesis.
Cell 1994;79(1):131-41.
1994: Marcus S; Polverino A; Barr M; Wigler M
Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7762-6.
1994: Jung V; Wei W; Ballester R; Camonis J; Mi S; Van Aelst L; Wigler M; Broek D
Two types of RAS mutants that dominantly interfere with activators of RAS.
Molecular and cellular biology 1994;14(6):3707-18.
1994: Xu H P; White M; Marcus S; Wigler M
Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe.
Molecular and cellular biology 1994;14(1):50-8.
1994: Lisitsyn N A; Segre J A; Kusumi K; Lisitsyn N M; Nadeau J H; Frankel W N; Wigler M H; Lander E S
Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis.
Nature genetics 1994;6(1):57-63.
1994: Lisitsyn N A; Leach F S; Vogelstein B; Wigler M H
Detection of genetic loss in tumors by representational difference analysis.
Cold Spring Harbor symposia on quantitative biology 1994;59():585-7.
1994: Van Aelst L; White M A; Wigler M H
Ras partners.
Cold Spring Harbor symposia on quantitative biology 1994;59():181-6.
1993: Ohlmeyer M H; Swanson R N; Dillard L W; Reader J C; Asouline G; Kobayashi R; Wigler M; Still W C
Complex synthetic chemical libraries indexed with molecular tags.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):10922-6.
1993: Bolger G; Michaeli T; Martins T; St John T; Steiner B; Rodgers L; Riggs M; Wigler M; Ferguson K
A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.
Molecular and cellular biology 1993;13(10):6558-71.
1993: Van Aelst L; Barr M; Marcus S; Polverino A; Wigler M
Complex formation between RAS and RAF and other protein kinases.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):6213-7.
1993: Michaeli T; Bloom T J; Martins T; Loughney K; Ferguson K; Riggs M; Rodgers L; Beavo J A; Wigler M
Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae.
The Journal of biological chemistry 1993;268(17):12925-32.
1993: Chardin P; Camonis J H; Gale N W; van Aelst L; Schlessinger J; Wigler M H; Bar-Sagi D
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
Science (New York, N.Y.) 1993;260(5112):1338-43.
1993: Gutmann D H; Boguski M; Marchuk D; Wigler M; Collins F S; Ballester R
Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis.
Oncogene 1993;8(3):761-9.
1993: Lisitsyn N; Lisitsyn N; Wigler M
Cloning the differences between two complex genomes.
Science (New York, N.Y.) 1993;259(5097):946-51.
1993: Neiman A M; Stevenson B J; Xu H P; Sprague G F; Herskowitz I; Wigler M; Marcus S
Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms.
Molecular biology of the cell 1993;4(1):107-20.
1993: Andersen L B; Ballester R; Marchuk D A; Chang E; Gutmann D H; Saulino A M; Camonis J; Wigler M; Collins F S
A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity.
Molecular and cellular biology 1993;13(1):487-95.
1993: Marcus S; Wigler M; Xu H P; Ballester R; Kawamukai M; Polverino A
RAS function and protein kinase cascades.
Ciba Foundation symposium 1993;176():53-61; discussion 61-6.
1992: Shibuya E K; Polverino A J; Chang E; Wigler M; Ruderman J V
Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9831-5.
1992: Xu H P; Rajavashisth T; Grewal N; Jung V; Riggs M; Rodgers L; Wigler M
A gene encoding a protein with seven zinc finger domains acts on the sexual differentiation pathways of Schizosaccharomyces pombe.
Molecular biology of the cell 1992;3(7):721-34.
1992: Gerst J E; Rodgers L; Riggs M; Wigler M
SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4338-42.
1992: Kawamukai M; Gerst J; Field J; Riggs M; Rodgers L; Wigler M; Young D
Genetic and biochemical analysis of the adenylyl cyclase-associated protein, cap, in Schizosaccharomyces pombe.
Molecular biology of the cell 1992;3(2):167-80.
1992: Wigler M; Sweet R; Sim G K; Wold B; Pellicer A; Lacy E; Maniatis T; Silverstein S; Axel R
Transformation of mammalian cells with genes from prokaryotes and eukaryotes. 1979.
Biotechnology (Reading, Mass.) 1992;24():444-52.
1991: Vojtek A; Haarer B; Field J; Gerst J; Pollard T D; Brown S; Wigler M
Evidence for a functional link between profilin and CAP in the yeast S. cerevisiae.
Cell 1991;66(3):497-505.
1991: Wang Y; Xu H P; Riggs M; Rodgers L; Wigler M
byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype.
Molecular and cellular biology 1991;11(7):3554-63.
1991: Daar I; Nebreda A R; Yew N; Sass P; Paules R; Santos E; Wigler M; Vande Woude G F
The ras oncoprotein and M-phase activity.
Science (New York, N.Y.) 1991;253(5015):74-6.
1991: Wang Y; Boguski M; Riggs M; Rodgers L; Wigler M
sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1.
Cell regulation 1991;2(6):453-65.
1991: Young D; O'Neill K; Broek D; Wigler M
The adenylyl cyclase-encoding gene from Saccharomyces kluyveri.
Gene 1991;102(1):129-32.
1991: Colicelli J; Nicolette C; Birchmeier C; Rodgers L; Riggs M; Wigler M
Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(7):2913-7.
1991: Gerst J E; Ferguson K; Vojtek A; Wigler M; Field J
CAP is a bifunctional component of the Saccharomyces cerevisiae adenylyl cyclase complex.
Molecular and cellular biology 1991;11(3):1248-57.
1991: Kawamukai M; Ferguson K; Wigler M; Young D
Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe.
Cell regulation 1991;2(2):155-64.
1990: Ballester R; Marchuk D; Boguski M; Saulino A; Letcher R; Wigler M; Collins F
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.
Cell 1990;63(4):851-9.
1990: Xu H P; Riggs M; Rodgers L; Wigler M
A gene from S. pombe with homology to E. coli RNAse III blocks conjugation and sporulation when overexpressed in wild type cells.
Nucleic acids research 1990;18(17):5304.
1990: Xu H P; Wang Y; Riggs M; Rodgers L; Wigler M
Biological activity of the mammalian RAP genes in yeast.
Cell regulation 1990;1(10):763-9.
1990: Wigler M H
Oncoproteins. GAPs in understanding Ras.
Nature 1990;346(6286):696-7.
1990: Birchmeier C; O'Neill K; Riggs M; Wigler M
Characterization of ROS1 cDNA from a human glioblastoma cell line.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4799-803.
1990: Colicelli J; Field J; Ballester R; Chester N; Young D; Wigler M
Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase.
Molecular and cellular biology 1990;10(6):2539-43.
1990: Wieland I; Bolger G; Asouline G; Wigler M
A method for difference cloning: gene amplification following subtractive hybridization.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(7):2720-4.
1990: Field J; Xu H P; Michaeli T; Ballester R; Sass P; Wigler M; Colicelli J
Mutations of the adenylyl cyclase gene that block RAS function in Saccharomyces cerevisiae.
Science (New York, N.Y.) 1990;247(4941):464-7.
1989: Ballester R; Michaeli T; Ferguson K; Xu H P; McCormick F; Wigler M
Genetic analysis of mammalian GAP expressed in yeast.
Cell 1989;59(4):681-6.
1989: Michaeli T; Field J; Ballester R; O'Neill K; Wigler M
Mutants of H-ras that interfere with RAS effector function in Saccharomyces cerevisiae.
The EMBO journal 1989;8(10):3039-44.
1989: Young D; Riggs M; Field J; Vojtek A; Broek D; Wigler M
The adenylyl cyclase gene from Schizosaccharomyces pombe.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7989-93.
1989: Colicelli J; Birchmeier C; Michaeli T; O'Neill K; Riggs M; Wigler M
Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3599-603.
1989: Powers S; O'Neill K; Wigler M
Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae.
Molecular and cellular biology 1989;9(2):390-5.
1989: Sharma S; Birchmeier C; Nikawa J; O'Neill K; Rodgers L; Wigler M
Characterization of the ros1-gene products expressed in human glioblastoma cell lines.
Oncogene research 1989;5(2):91-100.
1988: Young D; O'Neill K; Jessell T; Wigler M
Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(14):5339-42.
1988: Toda T; Cameron S; Sass P; Wigler M
SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits.
Genes & development 1988;2(5):517-27.
1988: Cameron S; Levin L; Zoller M; Wigler M
cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae.
Cell 1988;53(4):555-66.
1988: Field J; Nikawa J; Broek D; MacDonald B; Rodgers L; Wilson I A; Lerner R A; Wigler M
Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.
Molecular and cellular biology 1988;8(5):2159-65.
1988: Levin L R; Kuret J; Johnson K E; Powers S; Cameron S; Michaeli T; Wigler M; Zoller M J
A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation.
Science (New York, N.Y.) 1988;240(4848):68-70.
1988: Wigler M; Field J; Powers S; Broek D; Toda T; Cameron S; Nikawa J; Michaeli T; Colicelli J; Ferguson K
Studies of RAS function in the yeast Saccharomyces cerevisiae.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():649-55.
1987: Birchmeier C; Sharma S; Wigler M
Expression and rearrangement of the ROS1 gene in human glioblastoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):9270-4.
1987: Nikawa J; Cameron S; Toda T; Ferguson K M; Wigler M
Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae.
Genes & development 1987;1(9):931-7.
1987: Nikawa J; Sass P; Wigler M
Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae.
Molecular and cellular biology 1987;7(10):3629-36.
1987: Rabin M; Birnbaum D; Young D; Birchmeier C; Wigler M; Ruddle F H
Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements.
Oncogene research 1987;1(2):169-78.
1987: Toda T; Cameron S; Sass P; Zoller M; Wigler M
Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase.
Cell 1987;50(2):277-87.
1987: Field J; Broek D; Kataoka T; Wigler M
Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae.
Molecular and cellular biology 1987;7(6):2128-33.
1987: Johnson K E; Cameron S; Toda T; Wigler M; Zoller M J
Expression in Escherichia coli of BCY1, the regulatory subunit of cyclic AMP-dependent protein kinase from Saccharomyces cerevisiae. Purification and characterization.
The Journal of biological chemistry 1987;262(18):8636-42.
1987: Toda T; Cameron S; Sass P; Zoller M; Scott J D; McMullen B; Hurwitz M; Krebs E G; Wigler M
Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae.
Molecular and cellular biology 1987;7(4):1371-7.
1987: Broek D; Toda T; Michaeli T; Levin L; Birchmeier C; Zoller M; Powers S; Wigler M
The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway.
Cell 1987;48(5):789-99.
1986: Sass P; Field J; Nikawa J; Toda T; Wigler M
Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(24):9303-7.
1986: Powers S; Michaelis S; Broek D; Santa Anna S; Field J; Herskowitz I; Wigler M
RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor.
Cell 1986;47(3):413-22.
1986: Birchmeier C; Birnbaum D; Waitches G; Fasano O; Wigler M
Characterization of an activated human ros gene.
Molecular and cellular biology 1986;6(9):3109-16.
1986: Young D; Waitches G; Birchmeier C; Fasano O; Wigler M
Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains.
Cell 1986;45(5):711-9.
1986: Birchmeier C; Young D; Wigler M
Characterization of two new human oncogenes.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 2():993-1000.
1986: Toda T; Broek D; Field J; Michaeli T; Cameron S; Nikawa J; Sass P; Birchmeier C; Powers S; Wigler M
Exploring the function of RAS oncogenes by studying the yeast Saccharomyces cerevisiae.
Princess Takamatsu symposia 1986;17():253-60.
1985: Kataoka T; Broek D; Wigler M
DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase.
Cell 1985;43(2 Pt 1):493-505.
1985: Birchmeier C; Broek D; Wigler M
ras proteins can induce meiosis in Xenopus oocytes.
Cell 1985;43(3 Pt 2):615-21.
1985: Broek D; Samiy N; Fasano O; Fujiyama A; Tamanoi F; Northup J; Wigler M
Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins.
Cell 1985;41(3):763-9.
1985: Gross M; Sweet R W; Sathe G; Yokoyama S; Fasano O; Goldfarb M; Wigler M; Rosenberg M
Purification and characterization of human H-ras proteins expressed in Escherichia coli.
Molecular and cellular biology 1985;5(5):1015-24.
1985: Toda T; Uno I; Ishikawa T; Powers S; Kataoka T; Broek D; Cameron S; Broach J; Matsumoto K; Wigler M
In yeast, RAS proteins are controlling elements of adenylate cyclase.
Cell 1985;40(1):27-36.
1985: Kataoka T; Powers S; Cameron S; Fasano O; Goldfarb M; Broach J; Wigler M
Functional homology of mammalian and yeast RAS genes.
Cell 1985;40(1):19-26.
1985: Birchmeier C; Broek D; Toda T; Powers S; Kataoka T; Wigler M
Conservation and divergence of RAS protein function during evolution.
Cold Spring Harbor symposia on quantitative biology 1985;50():721-5.
1984: Tamanoi F; Walsh M; Kataoka T; Wigler M
A product of yeast RAS2 gene is a guanine nucleotide binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(22):6924-8.
1984: Fasano O; Birnbaum D; Edlund L; Fogh J; Wigler M
New human transforming genes detected by a tumorigenicity assay.
Molecular and cellular biology 1984;4(9):1695-705.
1984: Fasano O; Aldrich T; Tamanoi F; Taparowsky E; Furth M; Wigler M
Analysis of the transforming potential of the human H-ras gene by random mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(13):4008-12.
1984: Kataoka T; Powers S; McGill C; Fasano O; Strathern J; Broach J; Wigler M
Genetic analysis of yeast RAS1 and RAS2 genes.
Cell 1984;37(2):437-45.
1984: Powers S; Kataoka T; Fasano O; Goldfarb M; Strathern J; Broach J; Wigler M
Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins.
Cell 1984;36(3):607-12.
1983: Taparowsky E; Shimizu K; Goldfarb M; Wigler M
Structure and activation of the human N-ras gene.
Cell 1983;34(2):581-6.
1983: Barker D; McCoy M; Weinberg R; Goldfarb M; Wigler M; Burt R; Gardner E; White R
A test of the role of two oncogenes in inherited predisposition to colon cancer.
Molecular biology & medicine 1983;1(2):199-206.
1983: Shimizu K; Birnbaum D; Ruley M A; Fasano O; Suard Y; Edlund L; Taparowsky E; Goldfarb M; Wigler M
Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1.
Nature 1983;304(5926):497-500.
1983: Ryan J; Barker P E; Shimizu K; Wigler M; Ruddle F H
Chromosomal assignment of a family of human oncogenes.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(14):4460-3.
1983: Shimizu K; Goldfarb M; Suard Y; Perucho M; Li Y; Kamata T; Feramisco J; Stavnezer E; Fogh J; Wigler M H
Three human transforming genes are related to the viral ras oncogenes.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(8):2112-6.
1983: Shimizu K; Goldfarb M; Perucho M; Wigler M
Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(2):383-7.
1983: Kwoh T J; Zipser D; Wigler M
Mutational analysis of the cloned chicken thymidine kinase gene.
Journal of molecular and applied genetics 1983;2(2):191-200.
1983: Fasano O; Taparowsky E; Fiddes J; Wigler M; Goldfarb M
Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells.
Journal of molecular and applied genetics 1983;2(2):173-80.
1982: Taparowsky E; Suard Y; Fasano O; Shimizu K; Goldfarb M; Wigler M
Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change.
Nature 1982;300(5894):762-5.
1982: Goldfarb M; Shimizu K; Perucho M; Wigler M
Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells.
Nature 1982;296(5856):404-9.
1981: Perucho M; Goldfarb M; Shimizu K; Lama C; Fogh J; Wigler M
Human-tumor-derived cell lines contain common and different transforming genes.
Cell 1981;27(3 Pt 2):467-76.
1981: Wigler M H
The inheritance of methylation patterns in vertebrates.
Cell 1981;24(2):285-6.
1981: Wigler M; Levy D; Perucho M
The somatic replication of DNA methylation.
Cell 1981;24(1):33-40.
1981: Perucho M; Wigler M
Linkage and expression of foreign DNA in cultured animal cells.
Cold Spring Harbor symposia on quantitative biology 1981;45 Pt 2():829-38.
1980: Perucho M; Hanahan D; Wigler M
Genetic and physical linkage of exogenous sequences in transformed cells.
Cell 1980;22(1 Pt 1):309-17.
1980: Hanahan D; Lane D; Lipsich L; Wigler M; Botchan M
Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell.
Cell 1980;21(1):127-39.
1980: Wigler M; Perucho M; Kurtz D; Dana S; Pellicer A; Axel R; Silverstein S
Transformation of mammalian cells with an amplifiable dominant-acting gene.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(6):3567-70.
1980: Perucho M; Hanahan D; Lipsich L; Wigler M
Isolation of the chicken thymidine kinase gene by plasmid rescue.
Nature 1980;285(5762):207-10.
1979: Wold B; Wigler M; Lacy E; Maniatis T; Silverstein S; Axel R
Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(11):5684-8.
1979: Wigler M; Sweet R; Sim G K; Wold B; Pellicer A; Lacy E; Maniatis T; Silverstein S; Axel R
Transformation of mammalian cells with genes from procaryotes and eucaryotes.
Cell 1979;16(4):777-85.
1979: Wigler M; Pellicer A; Silverstein S; Axel R; Urlaub G; Chasin L
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(3):1373-6.
1978: Wigler M; Pellicer A; Silverstein S; Axel R
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor.
Cell 1978;14(3):725-31.
1978: Wigler M; DeFeo D; Weinstein I B
Induction of plasminogen activator in cultured cells by macrocyclic plant diterpene esters and other agents related to tumor promotion.
Cancer research 1978;38(5):1434-7.
1978: Pellicer A; Wigler M; Axel R; Silverstein S
The transfer and stable integration of the HSV thymidine kinase gene into mouse cells.
Cell 1978;14(1):133-41.
1978: Silverstein S; Wigler M; Pellicer A; Axel R
Identification of sequences coding for thymidine kinase in herpes simplex virus and transformed cell DNA.
IARC scientific publications 1978;(24 Pt 1):501-8.
1977: Viaje A; Slaga T J; Wigler M; Weinstein I B
Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator.
Cancer research 1977;37(5):1530-6.
1977: Wigler M; Silverstein S; Lee L S; Pellicer A; Cheng Y c; Axel R
Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells.
Cell 1977;11(1):223-32.
1976: Wigler M H; Axel R
Nucleosomes in metaphase chromosomes.
Nucleic acids research 1976;3(6):1463-71.
1976: Wigler M; Weinstein I B
Tumour promotor induces plasminogen activator.
Nature 1976;259(5540):232-3.
1976: Wigler M H; Neugut A I; Weinstein I B
Enucleation of mammalian cells in suspension.
Methods in cell biology 1976;14():87-93.
1975: Wigler M H; Weinstein I B
A preparative method for obtaining enucleated mammalian cells.
Biochemical and biophysical research communications 1975;63(3):669-74.

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