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Michael Wigler

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Zsofia Kinga Stadler; Joseph Vijai; Michael Wigler; Boris Yamrom; Rohini Rau-Murthy; Mark Robson; Michael Ronemus; Kara Sarrel; Kasmintan Schrader; Sohela Shah; Joel Sheinfeld; George Bosl; Diane Esposito; Darren Feldman; Nichole Hansen; Noah D Kauff; Jude Kendall; Robert J Klein; Yoon-Ha Lee; Anthony Leotta; Dan Levy; Steven M Lipkin; Rajmohan Murali; Larry Norton; Kenneth Offit
Rare de novo germline copy-number variation in testicular cancer.
Timour Baslan; Hilary Cox; Diane Esposito; Jude Kendall; B Lakshmi; Nicholas Navin; Kandasamy Ravi; Mike Riggs; Linda Rodgers; Asya Stepansky; Jennifer Troge; Michael Wigler; James Hicks
Genome-wide copy number analysis of single cells.
Wen Xue; Lars Zender; Jack Zhang; Johannes Zuber; James Hicks; Thomas Kitzing; Alexander Krasnitz; Weijun Luo; Scott Powers; Amy R Rappaport; Kate Revill; Stephanie Roessler; Nikolaus Schultz; Janelle Simon; Xin Wei Wang; Susann Weissmueller; Michael Wigler; Scott W Lowe
A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions.

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2012: Zsofia Kinga Stadler; Joseph Vijai; Michael Wigler; Boris Yamrom; Rohini Rau-Murthy; Mark Robson; Michael Ronemus; Kara Sarrel; Kasmintan Schrader; Sohela Shah; Joel Sheinfeld; George Bosl; Diane Esposito; Darren Feldman; Nichole Hansen; Noah D Kauff; Jude Kendall; Robert J Klein; Yoon-Ha Lee; Anthony Leotta; Dan Levy; Steven M Lipkin; Rajmohan Murali; Larry Norton; Kenneth Offit
Rare de novo germline copy-number variation in testicular cancer.
American journal of human genetics 2012;91(2):379-83.
2012: Timour Baslan; Hilary Cox; Diane Esposito; Jude Kendall; B Lakshmi; Nicholas Navin; Kandasamy Ravi; Mike Riggs; Linda Rodgers; Asya Stepansky; Jennifer Troge; Michael Wigler; James Hicks
Genome-wide copy number analysis of single cells.
Nature protocols 2012;7(6):1024-41.
2012: Wen Xue; Lars Zender; Jack Zhang; Johannes Zuber; James Hicks; Thomas Kitzing; Alexander Krasnitz; Weijun Luo; Scott Powers; Amy R Rappaport; Kate Revill; Stephanie Roessler; Nikolaus Schultz; Janelle Simon; Xin Wei Wang; Susann Weissmueller; Michael Wigler; Scott W Lowe
A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(21):8212-7.
2012: Yoon-ha Lee; Anthony Leotta; Dan Levy; Michael Ronemus; Michael Wigler; Diane Esposito; Vladimir Grubor; Jude Kendall; B Lakshmi; Kenny Ye; Boris Yamrom
Reducing system noise in copy number data using principal components of self-self hybridizations.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(3):E103-10.
2011: Guy Horev; Abba M Krieger; Jason P Lerch; Lakshmi Muthuswamy; Young-Eun E Son; Hannes Vogel; Michael Wigler; Andreas Buja; Jacob Ellegood; R Mark Henkelman; Alea A Mills
Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(41):17076-81.
2011: Sarah R Gilman; Ivan Iossifov; Dan Levy; Michael Ronemus; Michael Wigler; Dennis Vitkup
Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses.
Neuron 2011;70(5):898-907.
2011: Dan Levy; Steven Marks; Deepa Pai; Linda Rodgers; Michael Ronemus; Jennifer Troge; Andreas Buja; Ivan Iossifov; Jude Kendall; Abba Krieger; B Lakshmi; Yoon-ha Lee; Anthony Leotta; Boris Yamrom; Kenny Ye; Seungtai Yoon; Michael Wigler
Rare de novo and transmitted copy-number variation in autistic spectrum disorders.
Neuron 2011;70(5):886-97.
2011: Nicholas Navin; Jude Kendall; Jennifer Troge; Peter Andrews; Linda Rodgers; Jeanne McIndoo; Kerry Cook; Asya Stepansky; Dan Levy; Diane Esposito; Lakshmi Muthuswamy; Alexander Krasnitz; W Richard McCombie; James Hicks; Michael Wigler
Tumour evolution inferred by single-cell sequencing.
Nature 2011;472(7341):90-4.
2011: Sitharthan Kamalakaran; Vinay Varadan; Hege E Giercksky Russnes; Dan Levy; Jude Kendall; Angel Janevski; Michael Riggs; Nilanjana Banerjee; Marit Synnestvedt; Ellen Schlichting; Rolf Kåresen; K Shama Prasada; Harish Rotti; Ramachandra Rao; Laxmi Rao; Man-Hung Eric Tang; K Satyamoorthy; Robert Lucito; Michael Wigler; Nevenka Dimitrova; Bjørn Naume; Anne-Lise Borresen-Dale; James B Hicks
DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables.
Molecular oncology 2011;5(1):77-92.
2010: Hege G Russnes; Hans Kristian Moen Vollan; Ole Christian Lingjaerde; Alexander Krasnitz; Pär Lundin; Bjørn Naume; Therese Sørlie; Elin Borgen; Inga H Rye; Anita Langerød; Suet-Feung Chin; Andrew E Teschendorff; Philip J Stephens; Susanne Månér; Ellen Schlichting; Lars O Baumbusch; Rolf Kåresen; Michael P Stratton; Michael Wigler; Carlos Caldas; Anders Zetterberg; James Hicks; Anne-Lise Børresen-Dale
Genomic architecture characterizes tumor progression paths and fate in breast cancer patients.
Science translational medicine 2010;2(38):38ra47.
2010: Nicholas Navin; Alexander Krasnitz; Linda Rodgers; Kerry Cook; Jennifer Meth; Jude Kendall; Michael Riggs; Yvonne Eberling; Jennifer Troge; Vladimir Grubor; Dan Levy; Pär Lundin; Susanne Månér; Anders Zetterberg; James Hicks; Michael Wigler
Inferring tumor progression from genomic heterogeneity.
Genome research 2010;20(1):68-80.
2009: Anka Bric; Cornelius Miething; Carl Uli Bialucha; Claudio Scuoppo; Lars Zender; Alexander Krasnitz; Zhenyu Xuan; Johannes Zuber; Michael Wigler; James Hicks; RW McCombie; Michael T Hemann; Gregory J Hannon; Scott Powers; Scott W Lowe
Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.
Cancer cell 2009;16(4):324-35.
2009: Emily Hodges; Andrew D Smith; Jude Kendall; Zhenyu Xuan; Kandasamy Ravi; Michelle Rooks; Michael Q Zhang; Qian Ye; Arindam Bhattacharjee; leonardo brizuela; W Richard McCombie; Michael Wigler; Gregory J Hannon; James B Hicks
High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing.
Genome research 2009;19(9):1593-605.
2009: Vladimir Grubor; Alexander Krasnitz; Jennifer E Troge; Jennifer L Meth; B Lakshmi; Jude T Kendall; Boris Yamrom; Garrick Alex; Deepa Pai; Nicholas Navin; Lisa A Hufnagel; Yoon-Ha Lee; Kerry Cook; Steven Allen; Kanti Rai; Rajendra N Damle; Carlo Calissano; Nicholas Chiorazzi; Michael Wigler; Diane Esposito
Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA).
Blood 2009;113(6):1294-303.
2008: Lars Zender; Wen Xue; Johannes Zuber; Camile P Semighini; Alexander Krasnitz; Beicong Ma; Peggy Zender; Stefan Kubicka; John Luk; Peter Schirmacher; W Richard McCombie; Michael Wigler; James Hicks; Gregory J Hannon; Scott Powers; Scott W Lowe
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer.
Cell 2008;135(5):852-64.
2008: Wen Xue; Alexander Krasnitz; Robert Lucito; Raffaella Sordella; Linda Vanaelst; Carlos Cordon-Cardo; Stephan Singer; Florian Kuehnel; Michael Wigler; Scott Powers; Lars Zender; Scott W Lowe
DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma.
Genes & development 2008;22(11):1439-44.
2008: Maricela Alarcón; Brett S. Abrahams; Jennifer L Stone; Jacqueline Duvall; Julia V Perederiy; Jamee M Bomar; Jonathan Sebat; Michael Wigler; Christa Lese Martin; David Ledbetter; Stanley F Nelson; Rita M Cantor; Daniel Geschwind
Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene.
American journal of human genetics 2008;82(1):150-9.
2007: Chris M Egan; Srinath Sridhar; Michael Wigler; Ira M Hall
Recurrent DNA copy number variation in the laboratory mouse.
Nature genetics 2007;39(11):1384-9.
2007: Robert Lucito; Shubha Suresh; Kimberly Walter; Akhilesh Pandey; B Lakshmi; Alexander Krasnitz; Jonathan Sebat; Michael Wigler; Alison P Klein; Kieran Brune; Emily Palmisano; Anirban Maitra; Michael Goggins; Ralph Hruban
Copy-number variants in patients with a strong family history of pancreatic cancer.
Cancer biology & therapy 2007;6(10):1592-9.
2007: Xiaoyue Zhao; Anthony Leotta; Vlad Kustanovich; Clara Lajonchere; Daniel Geschwind; Kiely Law; Paul Law; Shanping Qiu; Catherine Lord; Jonathan Sebat; Kenny Ye; Michael Wigler
A unified genetic theory for sporadic and inherited autism.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12831-6.
2007: Jonathan Sebat; B Lakshmi; Dheeraj Malhotra; Jennifer Troge; Christa Lese Martin; Tom Walsh; Boris Yamrom; Seungtai Yoon; Alex Krasnitz; Jude Kendall; Anthony Leotta; Deepa Pai; Ray Zhang; Yoon-Ha Lee; James Hicks; Sarah J Spence; Annette T Lee; Kaija Puura; Terho Lehtimäki; David Ledbetter; Peter K Gregersen; Joel Bregman; James S Sutcliffe; Vaidehi Jobanputra; Wendy Chung; Dorothy Warburton; Mary-Claire King; David Skuse; Daniel Geschwind; T Conrad Gilliam; Qian Ye; Michael Wigler
Strong association of de novo copy number mutations with autism.
Science (New York, N.Y.) 2007;316(5823):445-9.
2006: Robert J Pelham; Linda Rodgers; Ira Hall; Robert Lucito; Ken Nguyen; Nicholas Navin; James Hicks; David Mu; Scott Powers; Michael Wigler; David Botstein
Identification of alterations in DNA copy number in host stromal cells during tumor progression.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(52):19848-53.
2006: James Hicks; Alexander Krasnitz; B Lakshmi; Nicholas Navin; Michael Riggs; Evan Leibu; Diane Esposito; Joan Alexander; Jennifer Troge; Vladimir Grubor; Seungtai Yoon; Michael Wigler; Kenny Ye; Anne-Lise Børresen-Dale; Bjørn Naume; Ellen Schlicting; Larry Norton; Torsten Hägerström; Lambert Skoog; Gert Auer; Susanne Månér; Pär Lundin; Anders Zetterberg
Novel patterns of genome rearrangement and their association with survival in breast cancer.
Genome research 2006;16(12):1465-79.
2006: Nicholas Navin; Vladimir Grubor; Jim Hicks; Evan Leibu; Elizabeth Thomas; Jennifer Troge; Michael Riggs; Pär Lundin; Susanne Månér; Jonathan Sebat; Anders Zetterberg; Michael Wigler
PROBER: oligonucleotide FISH probe design software.
Bioinformatics (Oxford, England) 2006;22(19):2437-8.
2006: B Lakshmi; Ira M Hall; Christopher Egan; Joan Alexander; Anthony Leotta; John Healy; Lars Zender; Mona S Spector; Wen Xue; Scott W Lowe; Michael Wigler; Robert Lucito
Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11234-9.
2006: Lars Zender; Mona S Spector; Wen Xue; Peer Flemming; Carlos Cordon-Cardo; John Silke; Sheung-Tat Fan; John Luk; Michael Wigler; Gregory J Hannon; David Mu; Robert Lucito; Scott Powers; Scott W Lowe
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach.
Cell 2006;125(7):1253-67.
2006: Joseph West; John Healy; Michael Wigler; William Casey; Bud Mishra
Validation of S. pombe sequence assembly by microarray hybridization.
Journal of computational biology : a journal of computational molecular cell biology 2006;13(1):1-20.
2005: Vaidehi Jobanputra; Jonathan Sebat; Jennifer Troge; Wendy Chung; Kwame Anyane-Yeboa; Michael Wigler; Dorothy Warburton
Application of ROMA (representational oligonucleotide microarray analysis) to patients with cytogenetic rearrangements.
Genetics in medicine : official journal of the American College of Medical Genetics 2005;7(2):111-8.
2005: James Hicks; L Muthuswamy; Alexander Krasnitz; Nicholas Navin; Michael Riggs; Vladimir Grubor; Diane Esposito; Joan Alexander; Jennifer Troge; Michael Wigler; S Maner; Pär Lundin; Anders Zetterberg
High-resolution ROMA CGH and FISH analysis of aneuploid and diploid breast tumors.
Cold Spring Harbor symposia on quantitative biology 2005;70():51-63.
2004: Raoul-Sam Daruwala; Archisman Rudra; Harry Ostrer; Robert Lucito; Michael Wigler; Bud Mishra
A versatile statistical analysis algorithm to detect genome copy number variation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(46):16292-7.
2004: Adam B Olshen; Venkatraman E Seshan; Robert Lucito; Michael Wigler
Circular binary segmentation for the analysis of array-based DNA copy number data.
Biostatistics (Oxford, England) 2004;5(4):557-72.
2004: Jonathan Sebat; B Lakshmi; Jennifer Troge; Joan Alexander; Janet Young; Pär Lundin; Susanne Månér; Hillary Massa; Megan Walker; Maoyen Chi; Nicholas Navin; Robert Lucito; John Healy; James Hicks; Kenny Ye; Andrew Reiner; T Conrad Gilliam; Barbara J Trask; Nick Patterson; Anders Zetterberg; Michael Wigler
Large-scale copy number polymorphism in the human genome.
Science (New York, N.Y.) 2004;305(5683):525-8.
2004: Elizabeth E Thomas; Nathan Srebro; Jonathan Sebat; Nicholas Navin; John Healy; Bud Mishra; Michael Wigler
Distribution of short paired duplications in mammalian genomes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(28):10349-54.
2003: John Healy; Elizabeth E Thomas; Jacob T Schwartz; Michael Wigler
Annotating large genomes with exact word matches.
Genome research 2003;13(10):2306-15.
2003: Robert Lucito; John Healy; Joan Alexander; Andrew Reiner; Diane Esposito; Maoyen Chi; Linda Rodgers; Amy Brady; Jonathan Sebat; Jennifer Troge; Joseph A West; Seth Rostan; Ken Nguyen; Scott Powers; Kenny Ye; Adam B Olshen; Venkatraman E Seshan; Larry Norton; Michael Wigler
Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number variation.
Genome research 2003;13(10):2291-305.
2003: David Mu; Liyun Chen; Xiping Zhang; Lei-Hoon See; Christina M Koch; Clifford Yen; James Jiayuan Tong; Lori Spiegel; Ken Nguyen; Allyson Servoss; Yue Peng; Lin Pei; Jeffrey R Marks; Scott W Lowe; Timothy Hoey; Lily Yeh Jan; W Richard McCombie; Michael Wigler; Scott Powers
Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.
Cancer cell 2003;3(3):297-302.
2003: Bud Mishra; Raoul-Sam Daruwala; Yi Zhou; Nadia Ugel; Alberto Policriti; Marco Antoniotti; Salvatore Paxia; Marc Rejali; Archisman Rudra; Vera Cherepinsky; Naomi Silver; William Casey; Carla Piazza; Marta Simeoni; Paolo Barbano; Marina Spivak; Jiawu Feng; Ofer Gill; Mysore Venkatesh; Fang Cheng; Bing Sun; Iuliana Ioniata; Thomas Anantharaman; E Jane Albert Hubbard; Amir Pnueli; David Harel; Vijay Chandru; Ramesh Hariharan; Michael Wigler; Frank Park; Shih-Chieh Lin; Yuri Lazebnik; Franz Winkler; Charles R Cantor; Alessandra Carbone; Mikhael Gromov
A sense of life: computational and experimental investigations with models of biochemical and evolutionary processes.
Omics : a journal of integrative biology 2003;7(3):253-68.
2002: Masaaki Hamaguchi; Jennifer L Meth; Christine von Klitzing; Wen Wei; Diane Esposito; Linda Rodgers; Tom Walsh; Piri Welcsh; Mary-Claire King; Michael Wigler
DBC2, a candidate for a tumor suppressor gene involved in breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13647-52.
2002: Michael Wigler; Bud Mishra
Genetics. Wild by nature.
Science (New York, N.Y.) 2002;296(5572):1407-8.
2001: JP Stolarov; K Chang; A Reiner; Linda Rodgers; Gregory J Hannon; Michael Wigler; V Mittal
Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13043-8.
2001: Klaus Scheffzek; P Grünewald; Sabine Wohlgemuth; W Kabsch; H Tu; Michael Wigler; Alfred Wittinghofer; Christian Herrmann
The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast.
Structure (London, England : 1993) 2001;9(11):1043-50.
2001: S Wen; JP Stolarov; Michael P Myers; Jing Dong Su; Michael Wigler; Nicholas K Tonks; Donald L Durden
PTEN controls tumor-induced angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4622-7.
2000: Robert Lucito; J West; Andrew Reiner; Joan Alexander; Diane Esposito; Bud Mishra; Scott Powers; Larry Norton; Michael Wigler
Detecting gene copy number fluctuations in tumor cells by microarray analysis of genomic representations.
Genome research 2000;10(11):1726-36.
1999: D L Dong; R Liu; R Sherlock; Michael Wigler; HP Nestler
Molecular forceps from combinatorial libraries prevent the farnesylation of Ras by binding to its carboxyl terminus.
Chemistry & biology 1999;6(3):133-41.
1999: H Tu; Michael Wigler
Genetic evidence for Pak1 autoinhibition and its release by Cdc42.
Molecular and cellular biology 1999;19(1):602-11.
1998: Michael P Myers; Ian Pass; Ian H Batty; Jeroen van der Kaay; JP Stolarov; B A Hemmings; Michael Wigler; C Peter Downes; Nicholas K Tonks
The lipid phosphatase activity of PTEN is critical for its tumor supressor function.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13513-8.
1998: Craig Webb; L Van Aelst; Michael Wigler; George Vande Woude
Signaling pathways in Ras-mediated tumorigenicity and metastasis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8773-8.
1998: Robert Lucito; M Nakimura; J A West; Y Han; K Chin; K Jensen; RW McCombie; Joe Gray; Michael Wigler
Genetic analysis using genomic representations.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4487-92.
1998: M Hamaguchi; E A O'Connor; T Chen; L Parnell; RW McCombie; Michael Wigler
Rapid isolation of cDNA by hybridization.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3764-9.
1997: H Tu; M Barr; D L Dong; Michael Wigler
Multiple regulatory domains on the Byr2 protein kinase.
Molecular and cellular biology 1997;17(10):5876-87.
1997: Michael P Myers; JP Stolarov; Charis Eng; Jing Li; SI Wang; Michael Wigler; Ramon Parsons; Nicholas K Tonks
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9052-7.
1997: Jing Li; C Yen; D Liaw; Katrina Podsypanina; S Bose; SI Wang; Janusz Puc; C Miliaresis; Linda Rodgers; RW McCombie; S H Bigner; B C Giovanella; Michael Ittmann; Benjamin Tycko; Hanina Hibshoosh; Michael Wigler; Ramon Parsons
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.
Science (New York, N.Y.) 1997;275(5308):1943-7.
1996: M M Barr; H Tu; Linda Van Aelst; Michael Wigler
Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.
Molecular and cellular biology 1996;16(10):5597-603.
1996: Michael A White; T Vale; J H Camonis; Erik M Schaefer; Michael Wigler
A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation.
The Journal of biological chemistry 1996;271(28):16439-42.
1996: S Thiagalingam; N A Lisitsyn; M Hamaguchi; Michael Wigler; James Willson; Sanford D Markowitz; F S Leach; Kenneth W Kinzler; Bert Vogelstein
Evaluation of the FHIT gene in colorectal cancers.
Cancer research 1996;56(13):2936-9.
1996: Roya Khosravi-Far; Michael A White; JK Westwick; P A Solski; Magdalena Wodnicka; Linda Van Aelst; Michael Wigler; Channing J Der
Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation.
Molecular and cellular biology 1996;16(7):3923-33.
1996: T Joneson; Michael A White; Michael Wigler; Dafna Bar-Sagi
Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.
Science (New York, N.Y.) 1996;271(5250):810-2.
1996: Hao-Peng X. Duffy; B L Yanak; Michael Wigler; Michael B Gorin
New polymorphic markers in the vicinity of the pearl locus on mouse chromosome 13.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(1):16-9.
1995: Stevan Marcus; A Polverino; E Chang; David J. Robbins; Melanie H Cobb; Michael Wigler
Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):6180-4.
1995: V Jung; L Chen; Hofmann Sandra; Michael Wigler; S Powers
Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins.
Molecular and cellular biology 1995;15(3):1333-42.
1995: Michael A White; C Nicolette; Audrey Minden; A Polverino; Linda Van Aelst; Michael Karin; Michael Wigler
Multiple Ras functions can contribute to mammalian cell transformation.
Cell 1995;80(4):533-41.
1995: N A Lisitsyn; N M Lisitsina; Guido Dalbagni; P Barker; C A Sanchez; J Gnarra; W M Linehan; Brian J Reid; Michael Wigler
Comparative genomic analysis of tumors: detection of DNA losses and amplification.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(1):151-5.
1995: N Lisitsyn; Michael Wigler
Representational difference analysis in detection of genetic lesions in cancer.
Methods in enzymology 1995;254():291-304.
1994: E C Chang; M Barr; Y Wang; V Jung; Hao-Peng X. Duffy; Michael Wigler
Cooperative interaction of S. pombe proteins required for mating and morphogenesis.
Cell 1994;79(1):131-41.
1994: Stevan Marcus; A Polverino; M Barr; Michael Wigler
Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7762-6.
1994: V Jung; W Wei; R Ballester; J Camonis; S Mi; Linda Van Aelst; Michael Wigler; Daniel Broek
Two types of RAS mutants that dominantly interfere with activators of RAS.
Molecular and cellular biology 1994;14(6):3707-18.
1994: Hao-Peng X. Duffy; M White; Stevan Marcus; Michael Wigler
Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe.
Molecular and cellular biology 1994;14(1):50-8.
1994: N A Lisitsyn; J A Segre; K Kusumi; N M Lisitsyn; J H Nadeau; W N Frankel; Michael Wigler; Eric S Lander
Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis.
Nature genetics 1994;6(1):57-63.
1994: N A Lisitsyn; F S Leach; Bert Vogelstein; Michael Wigler
Detection of genetic loss in tumors by representational difference analysis.
Cold Spring Harbor symposia on quantitative biology 1994;59():585-7.
1994: Linda Van Aelst; Michael A White; Michael Wigler
Ras partners.
Cold Spring Harbor symposia on quantitative biology 1994;59():181-6.
1993: M H Ohlmeyer; R N Swanson; L W Dillard; J C Reader; G Asouline; R Kobayashi; Michael Wigler; WC Still
Complex synthetic chemical libraries indexed with molecular tags.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):10922-6.
1993: G Bolger; T Michaeli; T Martins; T St John; B Steiner; L Rodgers; M Riggs; Michael Wigler; K Ferguson
A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.
Molecular and cellular biology 1993;13(10):6558-71.
1993: Linda Van Aelst; M Barr; Stevan Marcus; A Polverino; Michael Wigler
Complex formation between RAS and RAF and other protein kinases.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):6213-7.
1993: T Michaeli; T J Bloom; T Martins; Kate Loughney; K Ferguson; M Riggs; L Rodgers; Joseph A Beavo; Michael Wigler
Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae.
The Journal of biological chemistry 1993;268(17):12925-32.
1993: Pierre Chardin; J H Camonis; nicholas gale; Linda Van Aelst; J Schlessinger; Michael Wigler; Dafna Bar-Sagi
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
Science (New York, N.Y.) 1993;260(5112):1338-43.
1993: David H Gutmann; M Boguski; D Marchuk; Michael Wigler; Francis S Collins; R Ballester
Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis.
Oncogene 1993;8(3):761-9.
1993: N Lisitsyn; N Lisitsyn; Michael Wigler
Cloning the differences between two complex genomes.
Science (New York, N.Y.) 1993;259(5097):946-51.
1993: A M Neiman; B J Stevenson; Hao-Peng X. Duffy; George F Sprague; I Herskowitz; Michael Wigler; Stevan Marcus
Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms.
Molecular biology of the cell 1993;4(1):107-20.
1993: L B Andersen; R Ballester; D A Marchuk; E Chang; David H Gutmann; A M Saulino; J Camonis; Michael Wigler; Francis S Collins
A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity.
Molecular and cellular biology 1993;13(1):487-95.
1993: Stevan Marcus; Michael Wigler; Hao-Peng X. Duffy; R Ballester; M Kawamukai; A Polverino
RAS function and protein kinase cascades.
Ciba Foundation symposium 1993;176():53-61; discussion 61-6.
1992: Ellen K Shibuya; A J Polverino; E Chang; Michael Wigler; Joan V Ruderman
Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9831-5.
1992: Hao-Peng X. Duffy; T Rajavashisth; N Grewal; V Jung; M Riggs; L Rodgers; Michael Wigler
A gene encoding a protein with seven zinc finger domains acts on the sexual differentiation pathways of Schizosaccharomyces pombe.
Molecular biology of the cell 1992;3(7):721-34.
1992: Jeffrey E Gerst; L Rodgers; M Riggs; Michael Wigler
SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4338-42.
1992: M Kawamukai; Jeffrey E Gerst; J Field; M Riggs; L Rodgers; Michael Wigler; D Young
Genetic and biochemical analysis of the adenylyl cyclase-associated protein, cap, in Schizosaccharomyces pombe.
Molecular biology of the cell 1992;3(2):167-80.
1992: Michael Wigler; R Sweet; G K Sim; B Wold; A Pellicer; Elizabeth Lacy; T Maniatis; S Silverstein; Richard Axel
Transformation of mammalian cells with genes from prokaryotes and eukaryotes. 1979.
Biotechnology (Reading, Mass.) 1992;24():444-52.
1991: Anne B Vojtek; B Haarer; J Field; Jeffrey E Gerst; T D Pollard; S Brown; Michael Wigler
Evidence for a functional link between profilin and CAP in the yeast S. cerevisiae.
Cell 1991;66(3):497-505.
1991: I Daar; A R Nebreda; N Yew; P Sass; Richard S Paules; E Santos; Michael Wigler; George Vande Woude
The ras oncoprotein and M-phase activity.
Science (New York, N.Y.) 1991;253(5015):74-6.
1991: Y Wang; Hao-Peng X. Duffy; M Riggs; L Rodgers; Michael Wigler
byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype.
Molecular and cellular biology 1991;11(7):3554-63.
1991: D Young; K O'Neill; D Broek; Michael Wigler
The adenylyl cyclase-encoding gene from Saccharomyces kluyveri.
Gene 1991;102(1):129-32.
1991: Y Wang; M Boguski; M Riggs; L Rodgers; Michael Wigler
sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1.
Cell regulation 1991;2(6):453-65.
1991: J Colicelli; C Nicolette; C Birchmeier; L Rodgers; M Riggs; Michael Wigler
Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(7):2913-7.
1991: Jeffrey E Gerst; K Ferguson; Anne B Vojtek; Michael Wigler; J Field
CAP is a bifunctional component of the Saccharomyces cerevisiae adenylyl cyclase complex.
Molecular and cellular biology 1991;11(3):1248-57.
1991: M Kawamukai; K Ferguson; Michael Wigler; D Young
Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe.
Cell regulation 1991;2(2):155-64.
1990: R Ballester; D Marchuk; M Boguski; A Saulino; R Letcher; Michael Wigler; F Collins
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.
Cell 1990;63(4):851-9.
1990: Hao-Peng X. Duffy; M Riggs; L Rodgers; Michael Wigler
A gene from S. pombe with homology to E. coli RNAse III blocks conjugation and sporulation when overexpressed in wild type cells.
Nucleic acids research 1990;18(17):5304.
1990: Hao-Peng X. Duffy; Y Wang; M Riggs; L Rodgers; Michael Wigler
Biological activity of the mammalian RAP genes in yeast.
Cell regulation 1990;1(10):763-9.
1990: Michael Wigler
Oncoproteins. GAPs in understanding Ras.
Nature 1990;346(6286):696-7.
1990: C Birchmeier; K O'Neill; M Riggs; Michael Wigler
Characterization of ROS1 cDNA from a human glioblastoma cell line.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4799-803.
1990: J Colicelli; J Field; R Ballester; N Chester; D Young; Michael Wigler
Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase.
Molecular and cellular biology 1990;10(6):2539-43.
1990: I Wieland; G Bolger; G Asouline; Michael Wigler
A method for difference cloning: gene amplification following subtractive hybridization.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(7):2720-4.
1990: J Field; Hao-Peng X. Duffy; T Michaeli; R Ballester; P Sass; Michael Wigler; J Colicelli
Mutations of the adenylyl cyclase gene that block RAS function in Saccharomyces cerevisiae.
Science (New York, N.Y.) 1990;247(4941):464-7.
1989: R Ballester; T Michaeli; K Ferguson; Hao-Peng X. Duffy; F McCormick; Michael Wigler
Genetic analysis of mammalian GAP expressed in yeast.
Cell 1989;59(4):681-6.
1989: T Michaeli; J Field; R Ballester; K O'Neill; Michael Wigler
Mutants of H-ras that interfere with RAS effector function in Saccharomyces cerevisiae.
The EMBO journal 1989;8(10):3039-44.
1989: D Young; M Riggs; J Field; Anne B Vojtek; D Broek; Michael Wigler
The adenylyl cyclase gene from Schizosaccharomyces pombe.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7989-93.
1989: J Colicelli; C Birchmeier; T Michaeli; K O'Neill; M Riggs; Michael Wigler
Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3599-603.
1989: S Powers; K O'Neill; Michael Wigler
Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae.
Molecular and cellular biology 1989;9(2):390-5.
1989: S Sharma; C Birchmeier; J Nikawa; K O'Neill; L Rodgers; Michael Wigler
Characterization of the ros1-gene products expressed in human glioblastoma cell lines.
Oncogene research 1989;5(2):91-100.
1988: D Young; K O'Neill; T Jessell; Michael Wigler
Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(14):5339-42.
1988: S Cameron; L Levin; M Zoller; Michael Wigler
cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae.
Cell 1988;53(4):555-66.
1988: T Toda; S Cameron; P Sass; Michael Wigler
SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits.
Genes & development 1988;2(5):517-27.
1988: J Field; J Nikawa; Daniel Broek; B MacDonald; L Rodgers; I A Wilson; R A Lerner; Michael Wigler
Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.
Molecular and cellular biology 1988;8(5):2159-65.
1988: L R Levin; Jeffrey Kuret; K E Johnson; S Powers; S Cameron; T Michaeli; Michael Wigler; M J Zoller
A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation.
Science (New York, N.Y.) 1988;240(4848):68-70.
1988: Michael Wigler; J Field; S Powers; Daniel Broek; T Toda; S Cameron; J Nikawa; T Michaeli; J Colicelli; K Ferguson
Studies of RAS function in the yeast Saccharomyces cerevisiae.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():649-55.
1987: C Birchmeier; S Sharma; Michael Wigler
Expression and rearrangement of the ROS1 gene in human glioblastoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):9270-4.
1987: J Nikawa; S Cameron; T Toda; K M Ferguson; Michael Wigler
Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae.
Genes & development 1987;1(9):931-7.
1987: J Nikawa; P Sass; Michael Wigler
Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae.
Molecular and cellular biology 1987;7(10):3629-36.
1987: T Toda; S Cameron; P Sass; M Zoller; Michael Wigler
Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase.
Cell 1987;50(2):277-87.
1987: M Rabin; D Birnbaum; D Young; C Birchmeier; Michael Wigler; F H Ruddle
Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements.
Oncogene research 1987;1(2):169-78.
1987: K E Johnson; S Cameron; T Toda; Michael Wigler; M J Zoller
Expression in Escherichia coli of BCY1, the regulatory subunit of cyclic AMP-dependent protein kinase from Saccharomyces cerevisiae. Purification and characterization.
The Journal of biological chemistry 1987;262(18):8636-42.
1987: J Field; D Broek; T Kataoka; Michael Wigler
Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae.
Molecular and cellular biology 1987;7(6):2128-33.
1987: T Toda; S Cameron; P Sass; M Zoller; John D Scott; B McMullen; M Hurwitz; Edwin G Krebs; Michael Wigler
Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae.
Molecular and cellular biology 1987;7(4):1371-7.
1987: Daniel Broek; T Toda; T Michaeli; L Levin; C Birchmeier; M Zoller; S Powers; Michael Wigler
The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway.
Cell 1987;48(5):789-99.
1986: P Sass; J Field; J Nikawa; T Toda; Michael Wigler
Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(24):9303-7.
1986: S Powers; Susan Michaelis; Daniel Broek; S Santa Anna; J Field; I Herskowitz; Michael Wigler
RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor.
Cell 1986;47(3):413-22.
1986: C Birchmeier; D Birnbaum; G Waitches; O Fasano; Michael Wigler
Characterization of an activated human ros gene.
Molecular and cellular biology 1986;6(9):3109-16.
1986: D Young; G Waitches; C Birchmeier; O Fasano; Michael Wigler
Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains.
Cell 1986;45(5):711-9.
1986: C Birchmeier; D Young; Michael Wigler
Characterization of two new human oncogenes.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 2():993-1000.
1986: T Toda; Daniel Broek; J Field; T Michaeli; S Cameron; J Nikawa; P Sass; C Birchmeier; S Powers; Michael Wigler
Exploring the function of RAS oncogenes by studying the yeast Saccharomyces cerevisiae.
Princess Takamatsu symposia 1986;17():253-60.
1985: T Kataoka; D Broek; Michael Wigler
DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase.
Cell 1985;43(2 Pt 1):493-505.
1985: C Birchmeier; Daniel Broek; Michael Wigler
ras proteins can induce meiosis in Xenopus oocytes.
Cell 1985;43(3 Pt 2):615-21.
1985: D Broek; N Samiy; O Fasano; Asao Fujiyama; Fuyuhiko Tamanoi; J Northup; Michael Wigler
Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins.
Cell 1985;41(3):763-9.
1985: M Gross; Raymond W Sweet; G Sathe; S Yokoyama; O Fasano; mitchell goldfarb; Michael Wigler; M Rosenberg
Purification and characterization of human H-ras proteins expressed in Escherichia coli.
Molecular and cellular biology 1985;5(5):1015-24.
1985: C Birchmeier; Daniel Broek; T Toda; S Powers; T Kataoka; Michael Wigler
Conservation and divergence of RAS protein function during evolution.
Cold Spring Harbor symposia on quantitative biology 1985;50():721-5.
1985: T Toda; I Uno; T Ishikawa; S Powers; T Kataoka; Daniel Broek; S Cameron; J Broach; K Matsumoto; Michael Wigler
In yeast, RAS proteins are controlling elements of adenylate cyclase.
Cell 1985;40(1):27-36.
1985: T Kataoka; S Powers; S Cameron; O Fasano; mitchell goldfarb; J Broach; Michael Wigler
Functional homology of mammalian and yeast RAS genes.
Cell 1985;40(1):19-26.
1984: F Tamanoi; M Walsh; T Kataoka; Michael Wigler
A product of yeast RAS2 gene is a guanine nucleotide binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(22):6924-8.
1984: O Fasano; D Birnbaum; L Edlund; J Fogh; Michael Wigler
New human transforming genes detected by a tumorigenicity assay.
Molecular and cellular biology 1984;4(9):1695-705.
1984: O Fasano; T Aldrich; Fuyuhiko Tamanoi; Elizabeth J Taparowsky; M Furth; Michael Wigler
Analysis of the transforming potential of the human H-ras gene by random mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(13):4008-12.
1984: T Kataoka; S Powers; C McGill; O Fasano; Jeffrey N Strathern; J Broach; Michael Wigler
Genetic analysis of yeast RAS1 and RAS2 genes.
Cell 1984;37(2):437-45.
1984: S Powers; T Kataoka; O Fasano; mitchell goldfarb; Jeffrey N Strathern; J Broach; Michael Wigler
Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins.
Cell 1984;36(3):607-12.
1983: Elizabeth J Taparowsky; K Shimizu; mitchell goldfarb; Michael Wigler
Structure and activation of the human N-ras gene.
Cell 1983;34(2):581-6.
1983: David Barker; M McCoy; Robert A. Weinberg; mitchell goldfarb; Michael Wigler; R Burt; E Gardner; Raymond White
A test of the role of two oncogenes in inherited predisposition to colon cancer.
Molecular biology & medicine 1983;1(2):199-206.
1983: K Shimizu; D Birnbaum; M A Ruley; O Fasano; Y Suard; L Edlund; Elizabeth J Taparowsky; mitchell goldfarb; Michael Wigler
Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1.
Nature 1983;304(5926):497-500.
1983: J Ryan; Peter Barker; K Shimizu; Michael Wigler; F H Ruddle
Chromosomal assignment of a family of human oncogenes.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(14):4460-3.
1983: K Shimizu; mitchell goldfarb; Y Suard; M Perucho; Y Li; T Kamata; J Feramisco; E Stavnezer; J Fogh; Michael Wigler
Three human transforming genes are related to the viral ras oncogenes.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(8):2112-6.
1983: T J Kwoh; D Zipser; Michael Wigler
Mutational analysis of the cloned chicken thymidine kinase gene.
Journal of molecular and applied genetics 1983;2(2):191-200.
1983: O Fasano; Elizabeth J Taparowsky; J Fiddes; Michael Wigler; mitchell goldfarb
Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells.
Journal of molecular and applied genetics 1983;2(2):173-80.
1983: K Shimizu; mitchell goldfarb; M Perucho; Michael Wigler
Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(2):383-7.
1982: Elizabeth J Taparowsky; Y Suard; O Fasano; K Shimizu; mitchell goldfarb; Michael Wigler
Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change.
Nature 1982;300(5894):762-5.
1982: mitchell goldfarb; K Shimizu; M Perucho; Michael Wigler
Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells.
Nature 1982;296(5856):404-9.
1981: M Perucho; mitchell goldfarb; K Shimizu; C Lama; J Fogh; Michael Wigler
Human-tumor-derived cell lines contain common and different transforming genes.
Cell 1981;27(3 Pt 2):467-76.
1981: Michael Wigler
The inheritance of methylation patterns in vertebrates.
Cell 1981;24(2):285-6.
1981: Michael Wigler; D Levy; M Perucho
The somatic replication of DNA methylation.
Cell 1981;24(1):33-40.
1981: M Perucho; Michael Wigler
Linkage and expression of foreign DNA in cultured animal cells.
Cold Spring Harbor symposia on quantitative biology 1981;45 Pt 2():829-38.
1980: M Perucho; Douglas Hanahan; Michael Wigler
Genetic and physical linkage of exogenous sequences in transformed cells.
Cell 1980;22(1 Pt 1):309-17.
1980: Douglas Hanahan; D Lane; L Lipsich; Michael Wigler; Michael R Botchan
Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell.
Cell 1980;21(1):127-39.
1980: Michael Wigler; M Perucho; David Thomas Kurtz; S Dana; A Pellicer; Richard Axel; S Silverstein
Transformation of mammalian cells with an amplifiable dominant-acting gene.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(6):3567-70.
1980: M Perucho; Douglas Hanahan; L Lipsich; Michael Wigler
Isolation of the chicken thymidine kinase gene by plasmid rescue.
Nature 1980;285(5762):207-10.
1979: B Wold; Michael Wigler; Elizabeth Lacy; T Maniatis; S Silverstein; Richard Axel
Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(11):5684-8.
1979: Michael Wigler; R Sweet; G K Sim; B Wold; A Pellicer; Elizabeth Lacy; T Maniatis; S Silverstein; Richard Axel
Transformation of mammalian cells with genes from procaryotes and eucaryotes.
Cell 1979;16(4):777-85.
1979: Michael Wigler; A Pellicer; S Silverstein; Richard Axel; G Urlaub; L Chasin
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(3):1373-6.
1978: Michael Wigler; A Pellicer; S Silverstein; Richard Axel
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor.
Cell 1978;14(3):725-31.
1978: Michael Wigler; D DeFeo; I B Weinstein
Induction of plasminogen activator in cultured cells by macrocyclic plant diterpene esters and other agents related to tumor promotion.
Cancer research 1978;38(5):1434-7.
1978: A Pellicer; Michael Wigler; Richard Axel; S Silverstein
The transfer and stable integration of the HSV thymidine kinase gene into mouse cells.
Cell 1978;14(1):133-41.
1978: S Silverstein; Michael Wigler; A Pellicer; Richard Axel
Identification of sequences coding for thymidine kinase in herpes simplex virus and transformed cell DNA.
IARC scientific publications 1978;(24 Pt 1):501-8.
1977: A Viaje; Thomas Slaga; Michael Wigler; I B Weinstein
Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator.
Cancer research 1977;37(5):1530-6.
1977: Michael Wigler; S Silverstein; L S Lee; A Pellicer; Y c Cheng; Richard Axel
Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells.
Cell 1977;11(1):223-32.
1976: Michael Wigler; Richard Axel
Nucleosomes in metaphase chromosomes.
Nucleic acids research 1976;3(6):1463-71.
1976: Michael Wigler; I B Weinstein
Tumour promotor induces plasminogen activator.
Nature 1976;259(5540):232-3.
1976: Michael Wigler; Alfred I Neugut; I B Weinstein
Enucleation of mammalian cells in suspension.
Methods in cell biology 1976;14():87-93.
1975: Michael Wigler; I B Weinstein
A preparative method for obtaining enucleated mammalian cells.
Biochemical and biophysical research communications 1975;63(3):669-74.