Dale Wigley

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Lucarelli Debora; Wang Ying A; Galkin Vitold E; Yu Xiong; Wigley Dale B; Egelman Edward H
The RecB nuclease domain binds to RecA-DNA filaments: implications for filament loading.
Saikrishnan Kayarat; Powell Benjamin; Cook Nicola J; Webb Martin R; Wigley Dale B
Mechanistic basis of 5'-3' translocation in SF1B helicases.
Wigley Dale B
ORC proteins: marking the start.

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2009: Lucarelli Debora; Wang Ying A; Galkin Vitold E; Yu Xiong; Wigley Dale B; Egelman Edward H
The RecB nuclease domain binds to RecA-DNA filaments: implications for filament loading.
Journal of molecular biology 2009;391(2):269-74.
2009: Saikrishnan Kayarat; Powell Benjamin; Cook Nicola J; Webb Martin R; Wigley Dale B
Mechanistic basis of 5'-3' translocation in SF1B helicases.
Cell 2009;137(5):849-59.
2009: Wigley Dale B
ORC proteins: marking the start.
Current opinion in structural biology 2009;19(1):72-8.
2008: Saikrishnan Kayarat; Griffiths Stuart P; Cook Nicola; Court Robert; Wigley Dale B
DNA binding to RecD: role of the 1B domain in SF1B helicase activity.
The EMBO journal 2008;27(16):2222-9.
2007: Wigley Dale B
RecBCD: the supercar of DNA repair.
Cell 2007;131(4):651-3.
2007: Gaudier Martin; Schuwirth Barbara S; Westcott Sarah L; Wigley Dale B
Structural basis of DNA replication origin recognition by an ORC protein.
Science (New York, N.Y.) 2007;317(5842):1213-6.
2007: Singleton Martin R; Dillingham Mark S; Wigley Dale B
Structure and mechanism of helicases and nucleic acid translocases.
Annual review of biochemistry 2007;76():23-50.
2006: Grainge Ian; Gaudier Martin; Schuwirth Barbara S; Westcott Sarah L; Sandall Jane; Atanassova Neli; Wigley Dale B
Biochemical analysis of a DNA replication origin in the archaeon Aeropyrum pernix.
Journal of molecular biology 2006;363(2):355-69.
2006: Petalcorin Mark I R; Sandall Jane; Wigley Dale B; Boulton Simon J
CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing.
Journal of molecular biology 2006;361(2):231-42.
2006: Seybert Anja; Singleton Martin R; Cook Nicola; Hall David R; Wigley Dale B
Communication between subunits within an archaeal clamp-loader complex.
The EMBO journal 2006;25(10):2209-18.
2004: Singleton Martin R; Dillingham Mark S; Gaudier Martin; Kowalczykowski Stephen C; Wigley Dale B
Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks.
Nature 2004;432(7014):187-93.
2004: Singleton Martin R; Morales Renaud; Grainge Ian; Cook Nicola; Isupov Michail N; Wigley Dale B
Conformational changes induced by nucleotide binding in Cdc6/ORC from Aeropyrum pernix.
Journal of molecular biology 2004;343(3):547-57.
2004: Seybert Anja; Wigley Dale B
Distinct roles for ATP binding and hydrolysis at individual subunits of an archaeal clamp loader.
The EMBO journal 2004;23(6):1360-71.
2003: Singleton Martin R; Wigley Dale B
Multiple roles for ATP hydrolysis in nucleic acid modifying enzymes.
The EMBO journal 2003;22(18):4579-83.
2003: Grainge Ian; Scaife Sarah; Wigley Dale B
Biochemical analysis of components of the pre-replication complex of Archaeoglobus fulgidus.
Nucleic acids research 2003;31(16):4888-98.
2002: Seybert Anja; Scott David J; Scaife Sarah; Singleton Martin R; Wigley Dale B
Biochemical characterisation of the clamp/clamp loader proteins from the euryarchaeon Archaeoglobus fulgidus.
Nucleic acids research 2002;30(20):4329-38.
2002: Singleton Martin R; Wentzell Lois M; Liu Yilun; West Stephen C; Wigley Dale B
Structure of the single-strand annealing domain of human RAD52 protein.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13492-7.
2002: Soultanas P; Wigley D B
Site-directed mutagenesis reveals roles for conserved amino acid residues in the hexameric DNA helicase DnaB from Bacillus stearothermophilus.
Nucleic acids research 2002;30(18):4051-60.
2002: Singleton Martin R; Wigley Dale B
Modularity and specialization in superfamily 1 and 2 helicases.
Journal of bacteriology 2002;184(7):1819-26.
2002: Dillingham Mark S; Wigley Dale B; Webb Martin R
Direct measurement of single-stranded DNA translocation by PcrA helicase using the fluorescent base analogue 2-aminopurine.
Biochemistry 2002;41(2):643-51.
2001: McIlwraith M J; Hall D R; Stasiak A Z; Stasiak A; Wigley D B; West S C
RadA protein from Archaeoglobus fulgidus forms rings, nucleoprotein filaments and catalyses homologous recombination.
Nucleic acids research 2001;29(22):4509-17.
2001: Singleton M R; Scaife S; Raven N D; Wigley D B
Crystallization and preliminary X-ray analysis of RecG, a replication-fork reversal helicase from Thermotoga maritima complexed with a three-way DNA junction.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 11):1695-6.
2001: Singleton M R; Scaife S; Wigley D B
Structural analysis of DNA replication fork reversal by RecG.
Cell 2001;107(1):79-89.
2001: Dillingham M S; Soultanas P; Wiley P; Webb M R; Wigley D B
Defining the roles of individual residues in the single-stranded DNA binding site of PcrA helicase.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8381-7.
2001: Soultanas P; Wigley D B
Unwinding the 'Gordian knot' of helicase action.
Trends in biochemical sciences 2001;26(1):47-54.
2000: Timson D J; Singleton M R; Wigley D B
DNA ligases in the repair and replication of DNA.
Mutation research 2000;460(3-4):301-18.
2000: Soultanas P; Dillingham M S; Wiley P; Webb M R; Wigley D B
Uncoupling DNA translocation and helicase activity in PcrA: direct evidence for an active mechanism.
The EMBO journal 2000;19(14):3799-810.
2000: Singleton M R; Sawaya M R; Ellenberger T; Wigley D B
Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides.
Cell 2000;101(6):589-600.
2000: Wigley D B
DNA helicases: one small step for PcrA, one giant leap for RecBC?
Current biology : CB 2000;10(12):R444-6.
2000: Pan H; Wigley D B
Structure of the zinc-binding domain of Bacillus stearothermophilus DNA primase.
Structure (London, England : 1993) 2000;8(3):231-9.
2000: Soultanas P; Wigley D B
DNA helicases: 'inching forward'.
Current opinion in structural biology 2000;10(1):124-8.
2000: Dillingham M S; Wigley D B; Webb M R
Demonstration of unidirectional single-stranded DNA translocation by PcrA helicase: measurement of step size and translocation speed.
Biochemistry 2000;39(1):205-12.
2000: Bird L E; Pan H; Soultanas P; Wigley D B
Mapping protein-protein interactions within a stable complex of DNA primase and DnaB helicase from Bacillus stearothermophilus.
Biochemistry 2000;39(1):171-82.
1999: Dillingham M S; Soultanas P; Wigley D B
Site-directed mutagenesis of motif III in PcrA helicase reveals a role in coupling ATP hydrolysis to strand separation.
Nucleic acids research 1999;27(16):3310-7.
1999: Brannigan J A; Ashford S R; Doherty A J; Timson D J; Wigley D B
Nucleotide sequence, heterologous expression and novel purification of DNA ligase from Bacillus stearothermophilus(1).
Biochimica et biophysica acta 1999;1432(2):413-8.
1999: Soultanas P; Dillingham M S; Velankar S S; Wigley D B
DNA binding mediates conformational changes and metal ion coordination in the active site of PcrA helicase.
Journal of molecular biology 1999;290(1):137-48.
1999: Velankar S S; Soultanas P; Dillingham M S; Subramanya H S; Wigley D B
Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism.
Cell 1999;97(1):75-84.
1999: Pan H; Bird L E; Wigley D B
Cloning, expression, and purification of Bacillus stearothermophilus DNA primase and crystallization of the zinc-binding domain.
Biochimica et biophysica acta 1999;1444(3):429-33.
1999: Bird L E; Wigley D B
The Bacillus stearothermophilus replicative helicase: cloning, overexpression and activity.
Biochimica et biophysica acta 1999;1444(3):424-8.
1999: Soultanas P; Dillingham M S; Papadopoulos F; Phillips S E; Thomas C D; Wigley D B
Plasmid replication initiator protein RepD increases the processivity of PcrA DNA helicase.
Nucleic acids research 1999;27(6):1421-8.
1999: Singleton M R; Håkansson K; Timson D J; Wigley D B
Structure of the adenylation domain of an NAD+-dependent DNA ligase.
Structure (London, England : 1993) 1999;7(1):35-42.
1999: Timson D J; Wigley D B
Functional domains of an NAD+-dependent DNA ligase.
Journal of molecular biology 1999;285(1):73-83.
1999: Doherty A J; Wigley D B
Functional domains of an ATP-dependent DNA ligase.
Journal of molecular biology 1999;285(1):63-71.
1998: Bird L E; Brannigan J A; Subramanya H S; Wigley D B
Characterisation of Bacillus stearothermophilus PcrA helicase: evidence against an active rolling mechanism.
Nucleic acids research 1998;26(11):2686-93.
1998: Wigley D B
Teaching a new dog old tricks?
Structure (London, England : 1993) 1998;6(5):543-8.
1998: Soultanas P; Dillingham M S; Wigley D B
Escherichia coli ribosomal protein L3 stimulates the helicase activity of the Bacillus stearothermophilus PcrA helicase.
Nucleic acids research 1998;26(10):2374-9.
1998: Sherratt D J; Wigley D B
Conserved themes but novel activities in recombinases and topoisomerases.
Cell 1998;93(2):149-52.
1998: Bird L E; Subramanya H S; Wigley D B
Helicases: a unifying structural theme?
Current opinion in structural biology 1998;8(1):14-8.
1998: Hâkansson K; Wigley D B
Structure of a complex between a cap analogue and mRNA guanylyl transferase demonstrates the structural chemistry of RNA capping.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1505-10.
1997: Subramanya H S; Arciszewska L K; Baker R A; Bird L E; Sherratt D J; Wigley D B
Crystal structure of the site-specific recombinase, XerD.
The EMBO journal 1997;16(17):5178-87.
1997: Doherty A J; Håkansson K; Ho C K; Shuman S; Wigley D B
Crystallization of the RNA guanylyltransferase of Chlorella virus PBCV-1.
Acta crystallographica. Section D, Biological crystallography 1997;53(Pt 4):482-4.
1997: Bird L E; Hâkansson K; Pan H; Wigley D B
Characterization and crystallization of the helicase domain of bacteriophage T7 gene 4 protein.
Nucleic acids research 1997;25(13):2620-6.
1997: Håkansson K; Doherty A J; Shuman S; Wigley D B
X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes.
Cell 1997;89(4):545-53.
1996: Tsai F T; Subramanya H S; Brannigan J A; Wilkinson A J; Wigley D B
Crystallization and preliminary crystallographic analysis of the DNA gyrase B protein from B. stearothermophilus.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 6):1216-8.
1996: Subramanya H S; Bird L E; Brannigan J A; Wigley D B
Crystal structure of a DExx box DNA helicase.
Nature 1996;384(6607):379-83.
1996: Lewis R J; Tsai F T; Wigley D B
Molecular mechanisms of drug inhibition of DNA gyrase.
BioEssays : news and reviews in molecular, cellular and developmental biology 1996;18(8):661-71.
1996: Doherty A J; Ashford S R; Wigley D B
Characterization of proteolytic fragments of bacteriophage T7 DNA ligase.
Nucleic acids research 1996;24(12):2281-7.
1996: Subramanya H S; Peng H; Marians K J; Wigley D B
Preliminary crystallographic analysis of the ParE subunit of Escherichia coli topoisomerase IV.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 3):579-80.
1996: Subramanya H S; Doherty A J; Ashford S R; Wigley D B
Crystal structure of an ATP-dependent DNA ligase from bacteriophage T7.
Cell 1996;85(4):607-15.
1996: Doherty A J; Ashford S R; Subramanya H S; Wigley D B
Bacteriophage T7 DNA ligase. Overexpression, purification, crystallization, and characterization.
The Journal of biological chemistry 1996;271(19):11083-9.
1996: Lewis R J; Singh O M; Smith C V; Skarzynski T; Maxwell A; Wonacott A J; Wigley D B
The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography.
The EMBO journal 1996;15(6):1412-20.
1996: Wigley D B
A wasp head with a relaxing bite.
Structure (London, England : 1993) 1996;4(2):117-20.
1996: Subramanya H S; Roper D I; Dauter Z; Dodson E J; Davies G J; Wilson K S; Wigley D B
Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases.
Biochemistry 1996;35(3):792-802.
1995: Doherty A J; Ashford S R; Brannigan J A; Wigley D B
A superior host strain for the over-expression of cloned genes using the T7 promoter based vectors.
Nucleic acids research 1995;23(11):2074-5.
1995: Wigley D B
Structure and mechanism of DNA topoisomerases.
Annual review of biophysics and biomolecular structure 1995;24():185-208.
1994: Derrick J P; Wigley D B
The third IgG-binding domain from streptococcal protein G. An analysis by X-ray crystallography of the structure alone and in a complex with Fab.
Journal of molecular biology 1994;243(5):906-18.
1994: Roper D I; Subramanya H S; Shingler V; Wigley D B
Preliminary crystallographic analysis of 4-oxalocrotonate tautomerase reveals the oligomeric structure of the enzyme.
Journal of molecular biology 1994;243(4):799-801.
1994: Lewis R J; Singh O M; Smith C V; Maxwell A; Skarzynski T; Wonacott A J; Wigley D B
Crystallization of inhibitor complexes of an N-terminal 24 kDa fragment of the DNA gyrase B protein.
Journal of molecular biology 1994;241(1):128-30.
1994: Cameron A D; Roper D I; Moreton K M; Muirhead H; Holbrook J J; Wigley D B
Allosteric activation in Bacillus stearothermophilus lactate dehydrogenase investigated by an X-ray crystallographic analysis of a mutant designed to prevent tetramerization of the enzyme.
Journal of molecular biology 1994;238(4):615-25.
1993: Derrick J P; Wigley D B; Lian L Y; Sutcliffe M J; Yang J C; Dawson P D; Roberts G C
Structure and mechanism of streptococcal protein G.
Biochemical Society transactions 1993;21(4):333S.
1992: Roper D I; Moreton K M; Wigley D B; Holbrook J J
The structural consequences of exchanging tryptophan and tyrosine residues in B. stearothermophilus lactate dehydrogenase.
Protein engineering 1992;5(7):611-5.
1992: Derrick J P; Wigley D B
Crystal structure of a streptococcal protein G domain bound to an Fab fragment.
Nature 1992;359(6397):752-4.
1992: Derrick J P; Davies G J; Dauter Z; Wilson K S; Wigley D B
Crystallization and preliminary X-ray analysis of the complex between a mouse Fab fragment and a single IgG-binding domain from streptococcal protein G.
Journal of molecular biology 1992;227(4):1253-4.
1992: Wigley D B; Gamblin S J; Turkenburg J P; Dodson E J; Piontek K; Muirhead H; Holbrook J J
Structure of a ternary complex of an allosteric lactate dehydrogenase from Bacillus stearothermophilus at 2.5 A resolution.
Journal of molecular biology 1992;223(1):317-35.
1991: Wigley D B; Davies G J; Dodson E J; Maxwell A; Dodson G
Crystal structure of an N-terminal fragment of the DNA gyrase B protein.
Nature 1991;351(6328):624-9.
1991: Jackson A P; Maxwell A; Wigley D B
Preliminary crystallographic analysis of the ATP-hydrolysing domain of the Escherichia coli DNA gyrase B protein.
Journal of molecular biology 1991;217(1):15-7.
1990: Wigley D B; Derrick J P; Shaw W V
The serine acetyltransferase from Escherichia coli. Over-expression, purification and preliminary crystallographic analysis.
FEBS letters 1990;277(1-2):267-71.
1990: Reece R J; Dauter Z; Wilson K S; Maxwell A; Wigley D B
Preliminary crystallographic analysis of the breakage-reunion domain of the Escherichia coli DNA gyrase A protein.
Journal of molecular biology 1990;215(4):493-5.
1990: Hallett P; Grimshaw A J; Wigley D B; Maxwell A
Cloning of the DNA gyrase genes under tac promoter control: overproduction of the gyrase A and B proteins.
Gene 1990;93(1):139-42.
1989: Wigley D B; Roper D I; Cooper R A
Preliminary crystallographic analysis of 5-carboxymethyl-2-hydroxymuconate isomerase from Escherichia coli.
Journal of molecular biology 1989;210(4):881-2.
1988: Wigley D B; Muirhead H; Gamblin S J; Holbrook J J
Crystallization of a ternary complex of lactate dehydrogenase from Bacillus stearothermophilus.
Journal of molecular biology 1988;204(4):1041-3.
1988: Waldman A D; Hart K W; Clarke A R; Wigley D B; Barstow D A; Atkinson T; Chia W N; Holbrook J J
The use of genetically engineered tryptophan to identify the movement of a domain of B. stearothermophilus lactate dehydrogenase with the process which limits the steady-state turnover of the enzyme.
Biochemical and biophysical research communications 1988;150(2):752-9.
1987: Wigley D B; Lyall A; Hart K W; Holbrook J J
The greater strength of arginine: carboxylate over lysine carboxylate ion pairs implications for the design of novel enzymes and drugs.
Biochemical and biophysical research communications 1987;149(3):927-9.
1987: Wigley D B; Clarke A R; Dunn C R; Barstow D A; Atkinson T; Chia W N; Muirhead H; Holbrook J J
The engineering of a more thermally stable lactate dehydrogenase by reduction of the area of a water-accessible hydrophobic surface.
Biochimica et biophysica acta 1987;916(1):145-8.
1987: Atkinson T; Barstow D A; Chia W N; Clarke A R; Hart K W; Waldman A D; Wigley D B; Wilks H; Holbrook J J
Mapping motion in large proteins by single tryptophan probes inserted by site-directed mutagenesis: lactate dehydrogenase.
Biochemical Society transactions 1987;15(5):991-3.
1987: Hart K W; Clarke A R; Wigley D B; Waldman A D; Chia W N; Barstow D A; Atkinson T; Jones J B; Holbrook J J
A strong carboxylate-arginine interaction is important in substrate orientation and recognition in lactate dehydrogenase.
Biochimica et biophysica acta 1987;914(3):294-8.
1987: Hart K W; Clarke A R; Wigley D B; Chia W N; Barstow D A; Atkinson T; Holbrook J J
The importance of arginine 171 in substrate binding by Bacillus stearothermophilus lactate dehydrogenase.
Biochemical and biophysical research communications 1987;146(1):346-53.
1987: Clarke A R; Wigley D B; Barstow D A; Chia W N; Atkinson T; Holbrook J J
A single amino acid substitution deregulates a bacterial lactate dehydrogenase and stabilizes its tetrameric structure.
Biochimica et biophysica acta 1987;913(1):72-80.
1987: Waldman A D; Clarke A R; Wigley D B; Hart K W; Chia W N; Barstow D; Atkinson T; Munro I; Holbrook J J
The use of site-directed mutagenesis and time-resolved fluorescence spectroscopy to assign the fluorescence contributions of individual tryptophan residues in Bacillus stearothermophilus lactate dehydrogenase.
Biochimica et biophysica acta 1987;913(1):66-71.
1986: Clarke A R; Wigley D B; Chia W N; Barstow D; Atkinson T; Holbrook J J
Site-directed mutagenesis reveals role of mobile arginine residue in lactate dehydrogenase catalysis.
Nature 1986;324(6098):699-702.
1986: Barstow D A; Clarke A R; Chia W N; Wigley D; Sharman A F; Holbrook J J; Atkinson T; Minton N P
Cloning, expression and complete nucleotide sequence of the Bacillus stearothermophilus L-lactate dehydrogenase gene.
Gene 1986;46(1):47-55.

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