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Nadeeja Wijesekara

Research Profile

Anatomy

Living Beings

Chemicals & Drugs

Disorders

Phenomena

Blotting, Western

Physiology

Exocytosis

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Publications

TOP 3
A B Hardy; D Kong; K J Prentice; A Bhattacharjee; Fabrice CHIMIENTI; I Genkin; Nadeeja Wijesekara; Michael B Wheeler
Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8.
Nadeeja Wijesekara; Lin-hua Zhang; Thomas Abraham; Alpana Bhattacharjee; Martin H Kang; C Bruce Verchere; Garth L Warnock; Michael R Hayden
miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets.
Janine K Kruit; Dieter Lütjohann; Renmei Tang; Tim Vanmierlo; C Bruce Verchere; Cheryl L Wellington; Clara Westwell-Roper; Nadeeja Wijesekara; Alpana Bhattacharjee; Liam R Brunham; Willeke de Haan; James D Johnson; Michael R Hayden
Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function.

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All Publications

2012: A B Hardy; D Kong; K J Prentice; A Bhattacharjee; Fabrice CHIMIENTI; I Genkin; Nadeeja Wijesekara; Michael B Wheeler
Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8.
American journal of physiology. Endocrinology and metabolism 2012;302(9):E1084-96.
2012: Nadeeja Wijesekara; Lin-hua Zhang; Thomas Abraham; Alpana Bhattacharjee; Martin H Kang; C Bruce Verchere; Garth L Warnock; Michael R Hayden
miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets.
Diabetes 2012;61(3):653-8.
2012: Janine K Kruit; Dieter Lütjohann; Renmei Tang; Tim Vanmierlo; C Bruce Verchere; Cheryl L Wellington; Clara Westwell-Roper; Nadeeja Wijesekara; Alpana Bhattacharjee; Liam R Brunham; Willeke de Haan; James D Johnson; Michael R Hayden
Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function.
Diabetes 2012;61(3):659-64.
2011: Janine K Kruit; Peter E Light; Patrick E MacDonald; Brad J Marsh; Garry P Morgan; Gavin J Searle; Renmei Tang; C Bruce Verchere; Nadeeja Wijesekara; Alpana Bhattacharjee; Liam R Brunham; Adam J Costin; Xiao-Qing Dai; Jocelyn E Manning Fox; James D Johnson; Michael R Hayden
Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules.
Diabetes 2011;60(12):3186-96.
2011: A B Hardy; A S Serino; Fabrice CHIMIENTI; Nadeeja Wijesekara; Michael B Wheeler
Regulation of glucagon secretion by zinc: lessons from the β cell-specific Znt8 knockout mouse model.
Diabetes, obesity & metabolism 2011;13 Suppl 1():112-7.
2010: Nadeeja Wijesekara; Mansa Krishnamurthy; Alpana Bhattacharjee; Aamir Suhail; Gary Sweeney; Michael B Wheeler
Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion.
The Journal of biological chemistry 2010;285(44):33623-31.
2010: Nadeeja Wijesekara; Feihan F Dai; A B Hardy; P R Giglou; A Bhattacharjee; Vasilij Koshkin; Fabrice CHIMIENTI; Herbert Y Gaisano; G A Rutter; Michael B Wheeler
Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.
Diabetologia 2010;53(8):1656-68.
2009: Nadeeja Wijesekara; Fabrice CHIMIENTI; Michael B Wheeler
Zinc, a regulator of islet function and glucose homeostasis.
Diabetes, obesity & metabolism 2009;11 Suppl 4():202-14.
2009: Alexandre B Hardy; Jocelyn E Manning Fox; Pejman Raeisi Giglou; Nadeeja Wijesekara; Alpana Bhattacharjee; Sobia Sultan; Armen V Gyulkhandanyan; Herbert Y Gaisano; Patrick E MacDonald; Michael B Wheeler
Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets.
The Journal of biological chemistry 2009;284(44):30441-52.
2009: Accalia Fu; Andy Cheuk-Him Ng; Chantal Depatie; Nadeeja Wijesekara; Ying He; Gen-Sheng Wang; Nabeel Bardeesy; Fraser W Scott; Rhian M Touyz; Michael B Wheeler; Robert A Screaton
Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice.
Cell metabolism 2009;10(4):285-95.
2008: Hongfang Lu; Ying Yang; Emma M Allister; Nadeeja Wijesekara; Michael B Wheeler
The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach.
Molecular & cellular proteomics : MCP 2008;7(8):1434-51.
2008: Armen V Gyulkhandanyan; Hongfang Lu; Simon C Lee; Alpana Bhattacharjee; Nadeeja Wijesekara; Jocelyn E Manning Fox; Patrick E MacDonald; Fabrice CHIMIENTI; Feihan F Dai; Michael B Wheeler
Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells.
The Journal of biological chemistry 2008;283(15):10184-97.
2006: Nadeeja Wijesekara; Amanda Tung; Farah S L Thong; Amira Klip
Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK.
American journal of physiology. Endocrinology and metabolism 2006;290(6):E1276-86.
2005: Nadeeja Wijesekara; Daniel Konrad; Mohamed Eweida; Craig Jefferies; Nicole Liadis; Adria Giacca; Michael A Crackower; Akira Suzuki; Tak W Mak; C Ronald Kahn; Amira Klip; Minna Woo
Muscle-specific Pten deletion protects against insulin resistance and diabetes.
Molecular and cellular biology 2005;25(3):1135-45.
2003: Assaf Rudich; Daniel Konrad; Dóra Török; Ronit Ben-Romano; Carol Huang; Wenyan Niu; Rami R Garg; Nadeeja Wijesekara; R J Germinario; Philip J Bilan; Amira Klip
Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues.
Diabetologia 2003;46(5):649-58.