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Paul Wilder

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Jeremy L Yap; Xiaobo Cao; Kwan-Young Jung; Alexander D. Mackerell; Anjan Nan; Chander Peddaboina; W Roy Smythe; Kenno Vanommeslaeghe; Paul T Wilder; Stephen Fletcher
Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors.
Zhenghong Xu; Wenbo Yu; Alexander D. Mackerell; David Weber; Paul T Wilder; Aruna Battu; Karl X Chai; Li-Mei Chen; Ya-Wen Chen; Michael D Johnson; Chen-Yong Lin
Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade.
Naohiro Yamaguchi; Benjamin Prosser; Farshid Ghassemi; Le Xu; Daniel A Pasek; Jerry P Eu; Erick O Hernández-Ochoa; Brian R Cannon; Paul T Wilder; Richard M Lovering; David Weber; Werner Melzer; Martin F Schneider; Gerhard Meissner
Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1.

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All Publications

2012: Jeremy L Yap; Xiaobo Cao; Kwan-Young Jung; Alexander D. Mackerell; Anjan Nan; Chander Peddaboina; W Roy Smythe; Kenno Vanommeslaeghe; Paul T Wilder; Stephen Fletcher
Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors.
Organic & biomolecular chemistry 2012;10(15):2928-33.
2011: Zhenghong Xu; Wenbo Yu; Alexander D. Mackerell; David Weber; Paul T Wilder; Aruna Battu; Karl X Chai; Li-Mei Chen; Ya-Wen Chen; Michael D Johnson; Chen-Yong Lin
Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade.
Journal of medicinal chemistry 2011;54(21):7567-78.
2011: Naohiro Yamaguchi; Benjamin Prosser; Farshid Ghassemi; Le Xu; Daniel A Pasek; Jerry P Eu; Erick O Hernández-Ochoa; Brian R Cannon; Paul T Wilder; Richard M Lovering; David Weber; Werner Melzer; Martin F Schneider; Gerhard Meissner
Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1.
American journal of physiology. Cell physiology 2011;300(5):C998-C1012.
2010: Jing Lin; Qingyuan Yang; Paul T Wilder; France Carrier; David Weber
The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant melanoma.
The Journal of biological chemistry 2010;285(35):27487-98.
2010: Benoît Gilquin; Brian R Cannon; Arnaud Hubstenberger; Boualem Moulouel; Elin Falk; Nicolas Merle; Nicole Assard; Sylvie Kieffer; Denis Rousseau; Paul T Wilder; David Weber; jacques Baudier
The calcium-dependent interaction between S100B and the mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A.
Molecular and cellular biology 2010;30(11):2724-36.
2010: Thomas H Charpentier; Laura E Thompson; Melissa A Liriano; Kristen M Varney; Paul T Wilder; Edvin Pozharskiy; Eric A Toth; David Weber
The effects of CapZ peptide (TRTK-12) binding to S100B-Ca2+ as examined by NMR and X-ray crystallography.
Journal of molecular biology 2010;396(5):1227-43.
2009: Thomas H Charpentier; Paul T Wilder; Melissa A Liriano; Kristen M Varney; Shijun Zhong; Andrew Coop; Edvin Pozharskiy; Alexander D. Mackerell; Eric A Toth; David Weber
Small molecules bound to unique sites in the target protein binding cleft of calcium-bound S100B as characterized by nuclear magnetic resonance and X-ray crystallography.
Biochemistry 2009;48(26):6202-12.
2009: Nathan T Wright; Brian Cannon; Paul T Wilder; Michael T Morgan; Kristen M Varney; Danna Zimmer; David Weber
Solution structure of S100A1 bound to the CapZ peptide (TRTK12).
Journal of molecular biology 2009;386(5):1265-77.
2008: Thomas H Charpentier; Paul T Wilder; Melissa A Liriano; Kristen M Varney; Edvin Pozharskiy; Alexander D. Mackerell; Andrew Coop; Eric A Toth; David Weber
Divalent metal ion complexes of S100B in the absence and presence of pentamidine.
Journal of molecular biology 2008;382(1):56-73.
2008: Vladimir N Malashkevich; Kristen M Varney; Sarah C. Garrett; Paul T Wilder; David Knight; Thomas H Charpentier; Udupi A Ramagopal; Steven C Almo; David Weber; Anne R Bresnick
Structure of Ca2+-bound S100A4 and its interaction with peptides derived from nonmuscle myosin-IIA.
Biochemistry 2008;47(18):5111-26.
2007: Paul T Wilder; Thomas H Charpentier; David Weber
Hydrocarbon-stapled helices: a novel approach for blocking protein-protein interactions.
ChemMedChem 2007;2(8):1149-51.
2006: Paul T Wilder; Jing Lin; Catherine L Bair; Thomas H Charpentier; Dong Yang; Melissa Liriano; Kristen M Varney; Andrew Lee; Amos B Oppenheim; Sankar Adhya; France Carrier; David Weber
Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B.
Biochimica et biophysica acta 2006;1763(11):1284-97.
2005: Joseph Markowitz; Richard R Rustandi; Kristen M Varney; Paul T Wilder; Ryan Udan; Su Ling Wu; William DeW Horrocks; David Weber
Calcium-binding properties of wild-type and EF-hand mutants of S100B in the presence and absence of a peptide derived from the C-terminal negative regulatory domain of p53.
Biochemistry 2005;44(19):7305-14.
2005: Paul T Wilder; Kristen M Varney; Michele B Weiss; Rossitza K Gitti; David Weber
Solution structure of zinc- and calcium-bound rat S100B as determined by nuclear magnetic resonance spectroscopy.
Biochemistry 2005;44(15):5690-702.
2004: Jing Lin; Qingyuan Yang; Zhe Yan; Joseph Markowitz; Paul T Wilder; France Carrier; David Weber
Inhibiting S100B restores p53 levels in primary malignant melanoma cancer cells.
The Journal of biological chemistry 2004;279(32):34071-7.
2003: Paul T Wilder; Donna M Baldisseri; Ryan Udan; Kristen M Vallely; David Weber
Location of the Zn(2+)-binding site on S100B as determined by NMR spectroscopy and site-directed mutagenesis.
Biochemistry 2003;42(46):13410-21.
1998: Paul T Wilder; Richard R Rustandi; Alexander C Drohat; David Weber
S100B(betabeta) inhibits the protein kinase C-dependent phosphorylation of a peptide derived from p53 in a Ca2+-dependent manner.
Protein science : a publication of the Protein Society 1998;7(3):794-8.
1998: Richard R Rustandi; Alexander C Drohat; Donna M Baldisseri; Paul T Wilder; David Weber
The Ca(2+)-dependent interaction of S100B(beta beta) with a peptide derived from p53.
Biochemistry 1998;37(7):1951-60.