FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Steven Wiley

Research Profile

Chemicals & Drugs

Physiology

Anatomy

Concepts & Ideas

Phenomena

Living Beings

Mouse

Co-author Network

Publications

TOP 3
Harish Shankaran; H Steven Wiley; Yi Zhang; William B Chrisler; Jonathan A Ewald; Haluk Resat
Integrated experimental and model-based analysis reveals the spatial aspects of EGFR activation dynamics.
Katrina M Waters; Thomas J Weber; H Steven Wiley; Alan R Willse; Somnath Bandyopadhyay; Loel E Kathmann; Tao Liu; Ryan D Quesenberry; Richard D Smith; Brian D Thrall
Network analysis of epidermal growth factor signaling using integrated genomic, proteomic and phosphorylation data.
H Steven Wiley
Integrating multiple types of data for signaling research: challenges and opportunities.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Steven Wiley (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Harish Shankaran; H Steven Wiley; Yi Zhang; William B Chrisler; Jonathan A Ewald; Haluk Resat
Integrated experimental and model-based analysis reveals the spatial aspects of EGFR activation dynamics.
Molecular bioSystems 2012;8(11):2868-82.
2012: Katrina M Waters; Thomas J Weber; H Steven Wiley; Alan R Willse; Somnath Bandyopadhyay; Loel E Kathmann; Tao Liu; Ryan D Quesenberry; Richard D Smith; Brian D Thrall
Network analysis of epidermal growth factor signaling using integrated genomic, proteomic and phosphorylation data.
PloS one 2012;7(3):e34515.
2011: H Steven Wiley
Integrating multiple types of data for signaling research: challenges and opportunities.
Science signaling 2011;4(160):pe9.
2010: Harish Shankaran; H Steven Wiley
Oscillatory dynamics of the extracellular signal-regulated kinase pathway.
Current opinion in genetics & development 2010;20(6):650-5.
2010: Robin N Prince; Eric R Schreiter; Peng Zou; H Steven Wiley; Alice Y Ting; Richard T Lee; Douglas A Lauffenburger
The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release.
Journal of cell science 2010;123(Pt 13):2308-18.
2010: Elizabeth J Joslin; Harish Shankaran; Lee K Opresko; Nikki Bollinger; Douglas A Lauffenburger; H Steven Wiley
Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context.
Molecular bioSystems 2010;6(7):1293-306.
2010: Thomas J Weber; Harish Shankaran; H Steven Wiley; Lee K Opresko; William B Chrisler; Ryan D Quesenberry
Basic fibroblast growth factor regulates persistent ERK oscillations in premalignant but not malignant JB6 cells.
The Journal of investigative dermatology 2010;130(5):1444-56.
2009: Ronald C Taylor; Mudita Singhal; Don S Daly; Jason Gilmore; William R Cannon; Kelly Domico; Amanda M White; Deanna L Auberry; Kenneth J Auberry; Brian S Hooker; Greg Hurst; Jason E McDermott; W Hayes McDonald; Dale A Pelletier; Denise Schmoyer; H Steven Wiley
An analysis pipeline for the inference of protein-protein interaction networks.
International journal of data mining and bioinformatics 2009;3(4):409-30.
2009: Harish Shankaran; Danielle L Ippolito; William B Chrisler; Haluk Resat; Nikki Bollinger; Lee K Opresko; H Steven Wiley
Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor.
Molecular systems biology 2009;5():332.
2009: Yi Zhang; Lee K Opresko; Harish Shankaran; William B Chrisler; H Steven Wiley; Haluk Resat
HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells.
BMC cell biology 2009;10():78.
2008: Karin D Rodland; Nikki Bollinger; Danielle Ippolito; Lee K Opresko; Robert J Coffey; Richard C Zangar; H Steven Wiley
Multiple mechanisms are responsible for transactivation of the epidermal growth factor receptor in mammary epithelial cells.
The Journal of biological chemistry 2008;283(46):31477-87.
2008: Harish Shankaran; H Steven Wiley
Smad signaling dynamics: insights from a parsimonious model.
Science signaling 2008;1(36):pe41.
2007: Elizabeth J Joslin; Lee K Opresko; Alan Wells; H Steven Wiley; Douglas A Lauffenburger
EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation.
Journal of cell science 2007;120(Pt 20):3688-99.
2007: Harish Shankaran; Haluk Resat; H Steven Wiley
Cell surface receptors for signal transduction and ligand transport: a design principles study.
PLoS computational biology 2007;3(6):e101.
2007: Kenneth A Perrine; Brian L Lamarche; Derek F Hopkins; Scott E Budge; Lee K Opresko; H Steven Wiley; Marianne B Sowa
High speed method for in situ multispectral image registration.
Microscopy research and technique 2007;70(4):382-9.
2007: Harish Shankaran; H Steven Wiley; Haluk Resat
Receptor downregulation and desensitization enhance the information processing ability of signalling receptors.
BMC systems biology 2007;1():48.
2006: Harish Shankaran; H Steven Wiley; Haluk Resat
Modeling the effects of HER/ErbB1-3 coexpression on receptor dimerization and biological response.
Biophysical journal 2006;90(11):3993-4009.
2005: Galya Orr; dehong hu; Serdar Ozçelik; Lee K Opresko; H Steven Wiley; Steven D Colson
Cholesterol dictates the freedom of EGF receptors and HER2 in the plane of the membrane.
Biophysical journal 2005;89(2):1362-73.
2005: Jianying Dong; Lee K Opresko; William Chrisler; Galya Orr; Ryan D Quesenberry; Douglas A Lauffenburger; H Steven Wiley
The membrane-anchoring domain of epidermal growth factor receptor ligands dictates their ability to operate in juxtacrine mode.
Molecular biology of the cell 2005;16(6):2984-98.
2005: Michael I Monine; Alexander M Berezhkovskii; Elizabeth J Joslin; H Steven Wiley; Douglas A Lauffenburger; Stanislav Y Shvartsman
Ligand accumulation in autocrine cell cultures.
Biophysical journal 2005;88(4):2384-90.
2005: JH Miller; F Zheng; S Jin; Lee K Opresko; H Steven Wiley; Haluk Resat
A model of cytokine shedding induced by low doses of gamma radiation.
Radiation research 2005;163(3):337-42.
2005: Bart S Hendriks; Galya Orr; Alan Wells; H Steven Wiley; Douglas A Lauffenburger
Parsing ERK activation reveals quantitatively equivalent contributions from epidermal growth factor receptor and HER2 in human mammary epithelial cells.
The Journal of biological chemistry 2005;280(7):6157-69.
2004: Wan-Nan U Chen; Ronald L Woodbury; Loel E Kathmann; Lee K Opresko; Richard C Zangar; H Steven Wiley; Brian D Thrall
Induced autocrine signaling through the epidermal growth factor receptor contributes to the response of mammary epithelial cells to tumor necrosis factor alpha.
The Journal of biological chemistry 2004;279(18):18488-96.
2004: Ivan V Maly; H Steven Wiley; Douglas A Lauffenburger
Self-organization of polarized cell signaling via autocrine circuits: computational model analysis.
Biophysical journal 2004;86(1 Pt 1):10-22.
2003: Bart S Hendriks; H Steven Wiley; Douglas A Lauffenburger
HER2-mediated effects on EGFR endosomal sorting: analysis of biophysical mechanisms.
Biophysical journal 2003;85(4):2732-45.
2003: Haluk Resat; Jonathan Ewald; David A Dixon; H Steven Wiley
An integrated model of epidermal growth factor receptor trafficking and signal transduction.
Biophysical journal 2003;85(2):730-43.
2003: Bart S Hendriks; Lee K Opresko; H Steven Wiley; Douglas A Lauffenburger
Quantitative analysis of HER2-mediated effects on HER2 and epidermal growth factor receptor endocytosis: distribution of homo- and heterodimers depends on relative HER2 levels.
The Journal of biological chemistry 2003;278(26):23343-51.
2003: H Steven Wiley
Trafficking of the ErbB receptors and its influence on signaling.
Experimental cell research 2003;284(1):78-88.
2003: Bart S Hendriks; Lee K Opresko; H Steven Wiley; Douglas A Lauffenburger
Coregulation of epidermal growth factor receptor/human epidermal growth factor receptor 2 (HER2) levels and locations: quantitative analysis of HER2 overexpression effects.
Cancer research 2003;63(5):1130-7.
2003: Michael J Feldhaus; Robert W Siegel; Lee K Opresko; James R Coleman; Jane M Weaver Feldhaus; Yik A Yeung; Jennifer Cochran; Peter Heinzelman; David Colby; Jeffrey S Swers; Christilyn P Graff; H Steven Wiley; K Dane Wittrup
Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library.
Nature biotechnology 2003;21(2):163-70.
2003: H Steven Wiley; Stanislav Y Shvartsman; Douglas A Lauffenburger
Computational modeling of the EGF-receptor system: a paradigm for systems biology.
Trends in cell biology 2003;13(1):43-50.
2002: Ann DeWitt; Tomoko Iida; Ho-Yan Lam; Virginia Hill; H Steven Wiley; Douglas A Lauffenburger
Affinity regulates spatial range of EGF receptor autocrine ligand binding.
Developmental biology 2002;250(2):305-16.
2002: Stanislav Y Shvartsman; M P Hagan; Adly Yacoub; P Dent; H Steven Wiley; Douglas A Lauffenburger
Autocrine loops with positive feedback enable context-dependent cell signaling.
American journal of physiology. Cell physiology 2002;282(3):C545-59.
2001: G Maheshwari; H Steven Wiley; Douglas A Lauffenburger
Autocrine epidermal growth factor signaling stimulates directionally persistent mammary epithelial cell migration.
The Journal of cell biology 2001;155(7):1123-8.
2001: Gary R Holtom; Brian D Thrall; B Y Chin; H Steven Wiley; Steve Colson
Achieving molecular selectivity in imaging using multiphoton Raman spectroscopy techniques.
Traffic (Copenhagen, Denmark) 2001;2(11):781-8.
2001: Stanislav Y Shvartsman; H Steven Wiley; William M Deen; Douglas A Lauffenburger
Spatial range of autocrine signaling: modeling and computational analysis.
Biophysical journal 2001;81(4):1854-67.
2001: A E DeWitt; J Y Dong; H Steven Wiley; Douglas A Lauffenburger
Quantitative analysis of the EGF receptor autocrine system reveals cryptic regulation of cell response by ligand capture.
Journal of cell science 2001;114(Pt 12):2301-13.
2001: P Burke; K Schooler; H Steven Wiley
Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking.
Molecular biology of the cell 2001;12(6):1897-910.
2001: H Steven Wiley; PM Burke
Regulation of receptor tyrosine kinase signaling by endocytic trafficking.
Traffic (Copenhagen, Denmark) 2001;2(1):12-8.
2000: Jianying Dong; H Steven Wiley
Trafficking and proteolytic release of epidermal growth factor receptor ligands are modulated by their membrane-anchoring domains.
The Journal of biological chemistry 2000;275(1):557-64.
2000: K Schooler; H Steven Wiley
Ratiometric assay of epidermal growth factor receptor tyrosine kinase activation.
Analytical biochemistry 2000;277(1):135-42.
1999: JM Haugh; A C Huang; H Steven Wiley; Alan Wells; Douglas A Lauffenburger
Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts.
The Journal of biological chemistry 1999;274(48):34350-60.
1999: PM Burke; H Steven Wiley
Human mammary epithelial cells rapidly exchange empty EGFR between surface and intracellular pools.
Journal of cellular physiology 1999;180(3):448-60.
1999: Lars Damstrup; kuwada scott; Peter J Dempsey; CL Brown; C J Hawkey; Hans Skovgaard Poulsen; H Steven Wiley; Robert J Coffey
Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis.
British journal of cancer 1999;80(7):1012-9.
1999: Jianying Dong; Lee K Opresko; Peter J Dempsey; Douglas A Lauffenburger; R J Coffey; H Steven Wiley
Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6235-40.
1999: JM Haugh; K Schooler; Alan Wells; H Steven Wiley; Douglas A Lauffenburger
Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway.
The Journal of biological chemistry 1999;274(13):8958-65.
1999: Rebecca A Worthylake; Lee K Opresko; H Steven Wiley
ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors.
The Journal of biological chemistry 1999;274(13):8865-74.
1999: G Oehrtman; L Walker; B Will; Lee K Opresko; H Steven Wiley; Douglas A Lauffenburger
Quantitative assessment of autocrine cell loops.
Methods in molecular medicine 1999;18():143-54.
1999: kuwada scott; X F Li; Lars Damstrup; Peter J Dempsey; R J Coffey; H Steven Wiley
The dynamic expression of the epidermal growth factor receptor and epidermal growth factor ligand family in a differentiating intestinal epithelial cell line.
Growth factors (Chur, Switzerland) 1999;17(2):139-53.
1998: Douglas A Lauffenburger; G T Oehrtman; L Walker; H Steven Wiley
Real-time quantitative measurement of autocrine ligand binding indicates that autocrine loops are spatially localized.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15368-73.
1998: kuwada scott; K A Lund; X F Li; P Cliften; K Amsler; Lee K Opresko; H Steven Wiley
Differential signaling and regulation of apical vs. basolateral EGFR in polarized epithelial cells.
The American journal of physiology 1998;275(6 Pt 1):C1419-28.
1998: H Steven Wiley; Margaret F Woolf; Lee K Opresko; PM Burke; B Will; J R Morgan; Douglas A Lauffenburger
Removal of the membrane-anchoring domain of epidermal growth factor leads to intracrine signaling and disruption of mammary epithelial cell organization.
The Journal of cell biology 1998;143(5):1317-28.
1998: G T Oehrtman; H Steven Wiley; Douglas A Lauffenburger
Escape of autocrine ligands into extracellular medium: experimental test of theoretical model predictions.
Biotechnology and bioengineering 1998;57(5):571-82.
1997: Rebecca A Worthylake; H Steven Wiley
Structural aspects of the epidermal growth factor receptor required for transmodulation of erbB-2/neu.
The Journal of biological chemistry 1997;272(13):8594-601.
1995: A Nesterov; H Steven Wiley; Gordon N Gill
Ligand-induced endocytosis of epidermal growth factor receptors that are defective in binding adaptor proteins.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8719-23.
1995: Lee K Opresko; C P Chang; B H Will; P M Burke; Gordon N Gill; H Steven Wiley
Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain.
The Journal of biological chemistry 1995;270(9):4325-33.
1995: B H Will; Douglas A Lauffenburger; H Steven Wiley
Studies on engineered autocrine systems: requirements for ligand release from cells producing an artificial growth factor.
Tissue engineering 1995;1(1):81-94.
1994: Gerald G Krueger; J R Morgan; C M Jorgensen; L Schmidt; H L Li; M K Kwan; S T Boyce; H Steven Wiley; J Kaplan; Marta J Petersen
Genetically modified skin to treat disease: potential and limitations.
The Journal of investigative dermatology 1994;103(5 Suppl):76S-84S.
1994: J J Herbst; Lee K Opresko; B J Walsh; Douglas A Lauffenburger; H Steven Wiley
Regulation of postendocytic trafficking of the epidermal growth factor receptor through endosomal retention.
The Journal of biological chemistry 1994;269(17):12865-73.
1993: X H Liu; H Steven Wiley; A Wayne Meikle
Androgens regulate proliferation of human prostate cancer cells in culture by increasing transforming growth factor-alpha (TGF-alpha) and epidermal growth factor (EGF)/TGF-alpha receptor.
The Journal of clinical endocrinology and metabolism 1993;77(6):1472-8.
1991: C P Chang; Joseph Kao; C S Lazar; B J Walsh; A Wells; H Steven Wiley; Gordon N Gill; Michael G Rosenfeld
Ligand-induced internalization and increased cell calcium are mediated via distinct structural elements in the carboxyl terminus of the epidermal growth factor receptor.
The Journal of biological chemistry 1991;266(34):23467-70.
1991: H Steven Wiley; J J Herbst; B J Walsh; Douglas A Lauffenburger; Michael G Rosenfeld; Gordon N Gill
The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor.
The Journal of biological chemistry 1991;266(17):11083-94.
1990: K A Lund; C S Lazar; W S Chen; B J Walsh; J B Welsh; J J Herbst; G M Walton; Michael G Rosenfeld; Gordon N Gill; H Steven Wiley
Phosphorylation of the epidermal growth factor receptor at threonine 654 inhibits ligand-induced internalization and down-regulation.
The Journal of biological chemistry 1990;265(33):20517-23.
1990: Lee K Opresko; H Steven Wiley
Functional reconstitutional of the human epidermal growth factor receptor system in Xenopus oocytes.
The Journal of cell biology 1990;111(4):1661-71.
1990: K A Lund; Lee K Opresko; C Starbuck; B J Walsh; H Steven Wiley
Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization.
The Journal of biological chemistry 1990;265(26):15713-23.
1990: G J Heisermann; H Steven Wiley; B J Walsh; Holly A Ingraham; C J Fiol; Gordon N Gill
Mutational removal of the Thr669 and Ser671 phosphorylation sites alters substrate specificity and ligand-induced internalization of the epidermal growth factor receptor.
The Journal of biological chemistry 1990;265(22):12820-7.
1989: H Steven Wiley; B J Walsh; K A Lund
Global modulation of the epidermal growth factor receptor is triggered by occupancy of only a few receptors. Evidence for a binary regulatory system in normal human fibroblasts.
The Journal of biological chemistry 1989;264(32):18912-20.
1989: W S Chen; C S Lazar; K A Lund; J B Welsh; C P Chang; G M Walton; Channing J Der; H Steven Wiley; Gordon N Gill; Michael G Rosenfeld
Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation.
Cell 1989;59(1):33-43.
1988: D N McKinley; H Steven Wiley
Reassessment of fluid-phase endocytosis and diacytosis in monolayer cultures of human fibroblasts.
Journal of cellular physiology 1988;136(3):389-97.
1988: H Steven Wiley
Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system.
The Journal of cell biology 1988;107(2):801-10.
1988: Gordon N Gill; W S Chen; C S Lazar; J R Glenney; H Steven Wiley; Holly A Ingraham; Michael G Rosenfeld
Role of intrinsic protein tyrosine kinase in function and metabolism of the epidermal growth factor receptor.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():467-76.
1987: Lee K Opresko; H Steven Wiley
Receptor-mediated endocytosis in Xenopus oocytes. II. Evidence for two novel mechanisms of hormonal regulation.
The Journal of biological chemistry 1987;262(9):4116-23.
1987: Lee K Opresko; H Steven Wiley
Receptor-mediated endocytosis in Xenopus oocytes. I. Characterization of the vitellogenin receptor system.
The Journal of biological chemistry 1987;262(9):4109-15.
1987: H Steven Wiley; D N McKinley
Assay of growth factor stimulation of fluid-phase endocytosis.
Methods in enzymology 1987;146():402-17.
1985: H Steven Wiley; W VanNostrand; D N McKinley; D D Cunningham
Intracellular processing of epidermal growth factor and its effect on ligand-receptor interactions.
The Journal of biological chemistry 1985;260(9):5290-5.